Clinical, Preclinical and Health Sciences

Project Title	Contact
Functional genomics of biofilm development in the fungal pathogen Candida parapsilosis.	Prof Geraldine Butler
Novel mediators of progression and regression of diabetic kidney disease and fibrosis	Prof Catherine Godson
A novel role for immune modulators in hypoxia in the CNS	Dr John O Connor
Regulation of platelet functions in thrombosis	Dr Albert Smolenski
New methods to diagnose platelet hyperreactivity in patients at risk for arterial thrombosis	Dr Albert Smolenski
Investigation into a novel protease inhibitory mechanism for the anti-metastatic properties of heparin	Dr Margaret Worrall
The importance of endocytosis and protein trafficking for the function of antiangiogenic serpins	Dr Margaret Worrall
Development of skincare products from frog skin peptides	Dr Chandralal Hewage
NMR and molecular modeling studies of incretin hormones	Dr Chandralal Hewage
Structural studies of antimicrobial peptides	Dr Chandralal Hewage
Natural products for diabetic therapy	Dr Chandralal Hewage
Investigation of the role of anti sense proteins in the pathogenesis of Human T cell leukemia viruses	Dr Noreen Sheehy
Design and characterization of polymer-coated, enzyme-based biosensors for neurochemical monitoring of brain neurotransmitters and energy metabolites	Prof Robert O'Neil
The ascorbate–glutamate neurotransmission hypothesis: development of a selective microelectrochemical sensor for brain vitamin-C	Prof Robert O'Neil
Design and characterization of nanoparticle–polymer composite materials for biomedical devices	Prof Robert O'Neil
The antidepressant-sensitive serotonin transporter as a potential new drug target in Rheumatoid arthritis	Dr Jana Haase
Gender-specific regulation of serotonin transporter activity through G protein dependent mechanisms	Dr Jana Haase
Regulation of serotonin transporter expression and activity by pro-inflammatory cytokines – relevance for inflammation-induced depression	Dr Jana Haase
The exercise-induced skeletal muscle secretome and its role in metabolic homeostasis and exercise adaptation	Dr Brendan Egan
Molecular regulation of skeletal muscle mass and function in health and lifestyle-related chronic disease	Dr Brendan Egan
Diabetic Kidney Disease	Dr Tara McMorrow
Renal Toxicology and Toxicity Testing	Dr Tara McMorrow
Pathogenic mechanisms of leptospirosis	Dr Jarlath Nally
Small RNAs as controllers of virulence in Mycobacterium tuberculosis, the agent of human TB	Prof Stephen Gordon
Using chemical proteomics and network analysis to determine Host pathogen interactions of an emerging mycobacteria pathogen Mycobacterium abscessus	Prof Brendan Loftus Dr Gerard Cagney
Systems biology analysis of an emerging mycobacteria pathogen using transcriptomics to define conditionally essential genes in Mycobacterium abscessus	Prof Brendan Loftus Prof Stephen Gordon
Investigation of Wnt signaling by a model of Alzheimer’s disease	Dr Caroline E. Herron
Can modulation of PI3Kinase with Simvastatin attenuate the effects of beta amyloid peptide?	Dr Caroline E. Herron
Alternative, in vitro testing strategies for screening pharmaceuticals and chemicals for potential developmental toxicity: New horizons with a human induced pluripotent stem cell model (iPSTox).	Dr Helen Gallagher
Role of cell cycle signalling in neuroblastoma invasion and metastasis	Dr Helen Gallagher
Cell cycle proteomics – a systematic approach.	Dr Helen Gallagher
Studying transcriptional control of memory formation to find new treatments for disorders of cognitive function	Dr Keith Murphy
Clinical, Preclinical and Health Sciences	Dr Keith Murphy
Tracking faulty gene expression in cancer by dynamic mathematical modelling.	Prof Boris Kholodenko Prof Walter Kolch
Ocular Micro-Tremor Eye Movement Measurement as a Medical Diagnostic Tool	Prof John Sheridan
WNT signaling and the bone marrow microenvironment	Dr Patricia Maguire
A systems approach to determine the platelet releasate in health and disease	Dr Patricia Maguire
Platelets in inflammatory disease	Dr Patricia Maguire

UCD, Belfield, Dublin 4, Ireland. Tel : 353-1-716 4043

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