Galea G, Bexiga MG, Panarella A, O'Neill ED & Simpson JC (2015). A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking. J. Cell Sci. 128(13), 2339-2349.


Brayden DJ, Cryan SA, Dawson KA, O'Brien PJ & Simpson JC (2015). High-content analysis for drug delivery and nanoparticle applications. Review Article. Drug Discov. Today, in press. doi: 10.1016/j.drudis.2015.04.001. [Epub ahead of print].


Lecat S, Matthes HW, Pepperkok R, Simpson JC & Galzi JL (2015). A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways. Mol. Cell. Proteomics 14(5), 1385-1399.


Dunne CF, Twomey B, Kelly C, Simpson JC & Stanton KT (2015). Hydroxyapatite and fluorapatite coatings on dental screws: effects of blast coating process and biological response. J. Mater. Sci. Mater. Med. 26(1), 5347.


Carville NC, Collins L, Manzo M, Gallo K, Lukasz BI, McKayed KK, Simpson JC & Rodriguez BJ (2014). Biocompatibility of ferroelectric lithium niobate and the influence of polarization charge on osteoblast proliferation and function. J. Biomed. Mater. Res. 103(8), 2540-2548.


Varela JA, Aberg C, Simpson JC & Dawson KA (2014). Trajectory-based co-localization measures for nanoparticle-cell interaction studies. Small 11(17), 2026-2031.


Heffernan LH & Simpson JC (2014). The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport. Review Article. Biochem. Soc. Trans. 42(5), 1453-1459.


Farrell J, Kelly C, Rauch J, Kida K, Garcia-Munoz A, Monsefi N, Turriziani B, Doherty C, Mehta JP, Matallanas D, Simpson JC, Kolch W & von Kriegsheim A (2014). HGF induces epithelial-to-mesenchymal transition by modulating the mammalian Hippo/MST2 and ISG15 pathways. J. Proteome Res. 13(6), 2874-2886.


Higa- A, Taouji S, Lhomond S, Jensen D, Fernandez-Zapico ME, Simpson JC, Pasquet JM, Schekman R & Chevet E (2014). Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance. Mol. Cell Biol. 34(10), 1839-1849.


Sauvageau E, Rochdi MD, Oueslati M, Hamdan FF, Percherancier Y, Simpson JC, Pepperkok R & Bouvier M (2014). CNIH4 interacts with newly synthesized GPCR and control their export from the endoplasmic reticulum. Traffic 15(4), 383-400.


Bexiga MG, Kelly C, Dawson KA & Simpson JC (2014). RNA interference-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells. Nanomedicine 9(11), 1651-1664.


Michel G, Matthes HWD, Hachet-Haas M, El Baghdadi K, de May J, Pepperkok R, Simpson JC, Galzi J-L & Lecat S (2014). Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation. J. Cell Sci. 127, 773-787.


Galea G & Simpson JC (2013). High-content screening and analysis of the Golgi complex. Methods Cell Biol. 118, 281-295.


McKayed KK & Simpson JC (2013). Actin in action: Imaging approaches to study cytoskeleton structure and function. Review article. Cells, 2(4), 715-731.


Wang F, Bexiga MG, Anguissola S, Boya P, Simpson JC, Salvati A & Dawson KA (2013). Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles. Nanoscale 5(22), 10868-10876.


Bexiga MG & Simpson JC (2013). Human diseases associated with form and function of the Golgi complex. Review article. Int. J. Mol. Sci. 14(9), 18670-18681.


Miranda Caso Luengo AA, Miranda Caso Luengo R, Lieggi NT, Luo H, Simpson JC & Meijer WG (2013). A real-time impedance based method to assess Rhodococcus equi virulence. PLoS One 8(3): e60612.


Stadler C, Rexhepaj E, Singan VR, Murphy RF, Pepperkok R, Uhlen M, Simpson JC & Lundberg E (2013). Immunofluorescence and fluorescent protein-tagging show high correlation for protein localization in mammalian cells. Nature Methods 10, 315-323.


Singan VR, Handzic K & Simpson JC (2012). Quantitative image analysis approaches for probing Rab GTPase function and localisation in mammalian cells. Review Article. Biochem. Soc. Trans. 40(6), 1389-1393.


Varela JA, Bexiga MG, Aberg C, Simpson JC & Dawson KA (2012). Quantifying size-dependent interactions between fluorescently-labeled polystyrene nanoparticles and mammalian cells. J. Nanobiotechnology 10(1), 39.


Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, Bexiga MG, Singan VR, Heriche J-K, Neumann B, Mateos A, Blake J, Bechtel S, Benes V, Wiemann S, Ellenberg J & Pepperkok R (2012). Genome-wide RNAi screening identifies human proteins with a function in the early secretory pathway. Nature Cell Biol. 14, 764-774.


Singan VR, Handzic K, Curran KM & Simpson JC (2012). A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients. BMC Res. Notes, 5(1), 281.


Sandin P, Fitzpatrick LW, Simpson JC & Dawson KA (2012). High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells. ACS Nano 6, 1513-1521.


Singan VR, Jones TR, Curran KM & Simpson JC (2011). Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images. BMC Bioinformatics 12:407.


Simpson JC (2009). Screening the secretion machinery: high throughput imaging approaches to elucidate the secretory pathway. Review Article. Sem. Cell Dev. Biol. 20, 903-909.


Simpson JC, Cetin C, Erfle H, Joggerst B, Liebel U, Ellenberg J & Pepperkok R (2007). An RNAi screening platform to identify secretion machinery in mammalian cells. J. Biotechnology 129, 352-365.

Laketa V, Simpson JC, Bechtel S, Wiemann S & Pepperkok R (2007). High-content microscopy identifies new neurite outgrowth regulators. Mol. Biol. Cell 18, 242-252.

Starkuviene V, Liebel U, Simpson JC, Erfle H, Poustka A, Wiemann S & Pepperkok R (2004). High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic. Genome Res. 14, 1948-1956.

Erfle H, Simpson JC, Bastiaens PIH & Pepperkok R (2004). siRNA cell arrays for high content screening microscopy. Biotechniques 37, 454-462.

Liebel U, Starkuviene V, Erfle H, Simpson JC, Poustka A, Wiemann S & Pepperkok R (2003). A microscope-based screening platform for large scale functional analysis in intact cells. FEBS Lett. 554, 394-398.


Publications

UCD Cell Screening Laboratory

School of Biology and Environmental Science (SBES),

University College Dublin, Dublin 4, Ireland.

Email: cellscreening@ucd.ie

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