Skip navigation

UCD Search


Irish Drug Delivery Network


Journal Refereed Research Publications Supported by SFI award


IDDN Papers 2012



Amaro MI, Tajber L, Corrigan OI, Healy AM. Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation.Int J Pharm. 2011 Dec 12;421(1):99-109. Epub 2011 Sep 21.


Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C. In Vitro and In Vivo Characterisation of PEG-Lipid-Based Micellar Complexes of Salmon Calcitonin for Pulmonary Delivery.Pharm Res. 2012 Feb 10. [Epub ahead of print]


Bzik VA, Medani M, Baird AW, Winter DC, Brayden DJ. Mechanisms of action of zinc on rat intestinal epithelial electrogenic ion secretion: insights into its antidiarrhoeal actions.J Pharm Pharmacol. 2012 May;64(5):644-53.


Guo J, Cheng WP, Gu J, Ding C, Qu X, Yang Z, O'Driscoll C. Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice.Eur J Pharm Sci. 2012 Apr 11;45(5):521-32.


Hassan T, McKiernan PJ, McElvaney NG, Cryan SA, Greene CM. Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.Expert Rev Anti Infect Ther. 2012 Mar;10(3):359-68.


Keely S, Feighery L, Campion DP, O'Brien L, Brayden DJ, Baird AW. Chloride-led disruption of the intestinal mucous layer impedes Salmonella invasion: evidence for an 'enteric tear' mechanism.Cell Physiol Biochem. 2011;28(4):743-52. Epub 2011 Dec 14.


Májer F, Salomon JJ, Sharma R, Etzbach SV, Najib MN, Keaveny R, Long A, Wang J, Ehrhardt C, Gilmer JF. New fluorescent bile acids: synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid.Bioorg Med Chem. 2012 Mar 1;20(5):1767-78. Epub 2012 Jan 12.


McMahon A., O’Neill MJ., Gomez E., Donohue R., Forde D., Darcy R., and O’Driscoll CM. Targeted gene delivery to hepatocytes with galactosylated amphiphilic cyclodextrins, J. Pharmacy and Pharmacology, in press.


O’Mahony AM, Ogier J, Desgranges S, Cryan JF, Darcy R, O’Driscoll CM
A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery. Organic & Biomolecular Chemistry in press,


Salomon JJ, Endter S, Tachon G, Falson F, Buckley ST, Ehrhardt C. Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+)) in human respiratory epithelial cells.Eur J Pharm Biopharm. 2012 Mar 8. [Epub ahead of print]


Tierney EG, Duffy GP, Hibbitts AJ, Cryan SA, O'Brien FJ. The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds.J Control Release. 2012 Mar 10;158(2):304-11.




Amaro MI, Tajber L, Corrigan OI, Healy AM. Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation.Int J Pharm. 2011 Dec 12;421(1):99-109.


Baginski L, Tachon G, Falson F, Patton JS, Bakowsky U, Ehrhardt C. RT-PCR analysis of proteolytic enzymes in cultures of human respiratory epithelial cells. J Aerosol Med Pulm Drug Deliv 24(2):89-101, 2011


Baginski L, Tewes F, Buckley ST, Healy AM, Bakowsky U, Ehrhardt C. Investigations into the Fate of Inhaled Salmon Calcitonin at the Respiratory Epithelial Barrier. Pharm Res. 2011 Aug 5. [Epub ahead of print]


Duffy FJ, Verniere M, Devocelle M, Bernard E, Shields DC, Chubb AJ. CycloPs: generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids.J Chem Inf Model. 2011 Apr 25;51(4):829-36.


Gibbons A, Padilla-Carlin D, Kelly C, Hickey AJ, Taggart C, McElvaney NG, Cryan SA. The Effect of Liposome Encapsulation on the Pharmacokinetics of Recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) Therapy after Local Delivery to a Guinea Pig Asthma Model. Pharm Res. 2011 Jun 7. [Epub ahead of print]


Guo J, Bourre L, Soden DM, O'Sullivan GC, O'Driscoll C. Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?Biotechnol Adv. 2011 Jul-Aug;29(4):402-17.


Guo J, Cheng WP, Gu J, Ding C, Qu X, Yang Z, O’Driscoll CM. pH-triggered amphiphilic poly-L-lysine micelles potential for passive targeted delivery of siRNA to solid tumours: physicochemical characterizations and in vitro evaluations J. Controlled Release, Eur J Pharm Sci. 2012 Apr 11;45(5):521-32


Lawlor C, Kelly C, O'Leary S, O'Sullivan MP, Gallagher PJ, Keane J, Cryan SA. Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of MTb. Tuberculosis (Edinb). 2011 Jan;91(1):93-7.


Lawlor C, O'Sullivan MP, Sivadas N, O'Leary S, Gallagher PJ, Keane J, Cryan SA. The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages. Mol Pharm. 2011 Aug 1;8(4):1100-12


Ní ógáin O, Li J, Tajber L, Corrigan OI, Healy AM. Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery. Int J Pharm 405:23-35, 2011


O’Neill MJ, Bourre L, Melgar S, O’Driscoll CM, Intestinal delivery of non-viral gene therapeutics – physiological barriers & pre-clinical models. Drug Discov Today. 2011 Mar;16(5-6):203-18.


Paszko E, Ehrhardt C, Senge MO, Kelleher DP, Reynolds JV. Nanodrug applications in photodynamic therapy. Photodiagnosis Photodyn Ther8(1):14-29, 2011


Rahme, K Doody, T. Jain, AK, Chen, L, Morris, M O’DriscollC Holme,s JD Synthesis and Stabilisation of Gold Nanoparticles coated with Poly(ethylene glycol) for siRNA Delivery Biomedical Engineering 1 (1) e-issn 1945-5372




Rawlinson LA, O'Gara J, Jones DS, Brayden DJ. Resistance of Staphylococcus aureus to the cationic antimicrobial agent pDMAEMA is influenced by cell surface charge and hydrophobicity. J Med Microbiol. 2011 Mar 10. [Epub ahead of print]


Salomon JJ, Ehrhardt C. Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells. Eur J Pharm Biopharm77(3):392-7, 2011


Shoyele SA, Sivadas NK, Cryan SA, The effects of excipients and particle engineering on the biophysical stability and aerosol performance of parathyroid hormone (1-34) prepared as a dry powder for Inhalation AAPS PharmSciTech 2011 Mar;12(1):304-11


Sivadas N, Cryan SA.


Inhalable, bioresponsive microparticles for targeted drug delivery in the lungs. J Pharm Pharmacol. 2011 Mar;63(3):369-75


Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM. Evaluation of HPβCD-PEG Microparticles for Salmon Calcitonin Administration via Pulmonary Delivery. Mol Pharm. 2011 Sep 15. [Epub ahead of print]


Walsh EG, Maher S, Devocelle M, O'Brien PJ, Baird AW, Brayden DJ High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs. Peptides. 2011 Aug;32(8):1764-73




Amaro MI, Tajber L, Corrigan, OI, Healy, AM. Design of experiment to study the effect of spray dryer operating variables on sugar powders intended for inhalation, J Pharm Pharmacol, 52 (10 Sp. Iss.): 1413 – 1414, 2010


Brayden DJ, Armstrong G, O’Driscoll CM. The 2nd Annual Irish Drug Delivery Network Conference with UK and Ireland Controlled Release Society – Advancing Drug DeliveryTherapeutic Delivery 1 (4)


Brayden DJ, Oudot EJ, Baird AW. Drug delivery systems in domestic animal species. Handb Exp Pharmacol. 2010;(199):79-112. Review.Brayden DJ, Maher S. Invited Editorial (Peer-reviewed). Absorption enhancement: taking the next steps in therapeutic delivery. Therapeutic Delivery, Inaugural Issue, 1, 1-5
Cheng W-P, Thompson C, Ryan SM, Aguirre T, Tetley L, Brayden DJ. In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte salmon calcitonin nanocomplexes. J. Control. Release (In Press).
Coakley J, Hogan N, McGuire L, Griffin B, Casey C, Campbell C, Crean A. A Methodology for nnowledge management in biopharmaceutical production pharmaceutical engineering, 30, 3, 40
Faisal W, O’Driscoll CM, Griffin, BT, Bioavailability of lycopene in the rat: the role of intestinal lymphatic transport. J. Pharm. Pharmacol, 62, 323-331
Gaspar MM, Gobbo O, Ehrhardt, C. Generation of liposome aerosols with the Aeroneb Pro™ and the AeroProbe™ nebulisers. J Liposome Res 20, 1, 55-61, 2010
Gibbons A, McElvaney NG, Cryan SA, A dry powder formulation of liposome-encapsulated recombinant Secretary Leukocyte Protease Inhibitor (rSLPI)for inhalation: preparation and charactersiation, AAPS PharmSci.Tech. 2010 Sep;11(3):1411-21
Guo J, Fisher KA, Darcy R, Cryan JF, O'Driscoll C. Therapeutic targeting in the silent era: advances in non-viral siRNA delivery Molecular Biosystems, Mol Biosyst. 2010 Jul 15;6(7):1143-61.


Kelly C, Jefferies C, Cryan SA. Targeted Liposomal Drug Delivery to Monocytes and Macrophages. Epub October 2010
Maher S, Devocelle M, Ryan S, McClean S, Brayden DJ. Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin Int. J. Pharm, 387, 154-160
Patton JS, Brain JD, Davies LA, Fiegel J, Gumbleton M, Kim KJ, Sakagami M, Vanbever R, Ehrhardt C. The particle has landed - discerning the fate of inhaled pharmaceuticals, J Aerosol Med Pulm Drug Deliv 23 Suppl 2:S71-87, 2010
Rawlinson LA, O’Brien PJ, Brayden DJ, High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures. J. Control. Release, 146(1):84-92
Rawlinson LA, Ryan SM, Mantovani G, Syrett JA, Haddleton DM, Brayden DJ.
Antibacterial Effects of Poly(2-(dimethylamino ethyl)methacrylate) against Selected Gram-Positive and Gram-Negative Bacteria. Biomacromolecules, 11(2):443-53


Ryan SM, Freas J, Haddleton DM, Brayden DJ. PK/PD modelling of comb-shaped poly(polyethylene)methyl ether methacrylate salmon calcitonin conjugates of differing molecular weights J Control Release. 2011 Jan 20;149(2):126-32 (Epub 2010)
Sitterberg J, Gaspar MM, Ehrhardt C, Bakowski U. Use of atomic force microscopy for the characterization of proteo-liposomes Methods Mol. Biol., 606, 65-72, 2010
Sitterberg J, Özcetin A, Ehrhardt C, Bakowsky U. Using atomic force microscopy for the characterisation of nanoscale drug delivery systems Eur J Pharm Biopharm 74(1):2-13, 2010
Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM. Development and characterisation of soluble polymeric particles for pulmonary peptide delivery Eur J Pharm Sci 41(2):337-352, 2010


Wang X, Maher S, Brayden DJ, Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate, Therapeutic Delivery, Inaugural Issue, 1, 65-72



Byrne C, Sallas F, Rai DK, Ogier J, Darcy R, Poly-6-cationic amphiphilic cyclodextrins designed for gene delivery. Org. Biomol. Chem., 7, 18, 37, 63-71
Cryan SA, Kelly C, Shoyele S. Respiratory antiviral-drugs, vaccines and novel therapies, Respiratory Drug Delivery Europe, 1, 49-56
Endter S, Francombe D, Ehrhardt E, Gumbleton M, RT-PCR analysis of ABC, SLC and SLCO Drug Transporters in human lung epithelial cell models J Pharm Pharmacol, 61, 583-591, 2009
Horálková L, Radziwon A, Endter S, Andersen R, Koslowski R, Radomski MW, Dole┼żal P, Ehrhardt C. Characterisation of the R3/1 cell line as an alveolar epithelial cell model for drug disposition studies Eur J Pharm Sci, 36(4-5):444-50, 2009
Jones MW, Mantovani G, Ryan SM, Wang X, Brayden DJ, Haddleton DM. Phosphine-mediated one-pot thiol-ene “click” approach to polymer-protein conjugates. Chem. Comm. 35, 5272-5274
Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, Brayden DJ. Dexamethasone-poly(dimethylamino)ethyl methacrylate (pDMAEMA) conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers, J Control Release. 2009 Apr 2;135(1):35-43
Maher S, Kennelly, R, Bzik, V, Baird AW, Wang X, Winter D, Brayden DJ. Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae. European J. Pharm. Sci, 38, 4 291-300
Maher S, Leonard TW, Jacobsen J, Brayden DJ. Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic Advanced drug Delivery Reviews (Editor’s Choice Issue), 61, 15, 1427-1445
Maher S, Wang X, Bzik V, McClean S, Brayden DJ. Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies. European J. Pharm. Sci, 38, 4, 301-311
Rathbone MR, Brayden DJ. Controlled drug release in farmed animals: commercial challenges and academic opportunities, Current Drug Del. 6, 4, 383-390
Ryan S, Wang X, Mantovani G, Sayers CT, Haddleton DM, Brayden DJ. Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate, J. Controlled Release, 135, 51-59
Shoyele S, Ryan S, Cryan SA. Spray-freeze dried salmon calcitonin (SCT) for the treatment of osteoporosis by inhalation, Respiratory Drug Delivery Europe, 2, 365-368




Durcan N, Murphy C., Cryan SA. Inhalable siRNA, Molecular Pharmaceutics, 2008, 5(4), 559-66
Griffin BT and O’Driscoll CM, Models of the small intestine Drug Absorption Studies - in situ, in vitro, and in silico models", p: 34-88
Hayeshi R, Hilgendorf C, Artursson P, Augustijns P, Brodin B, Dehertogh P, Fisher K, Fossati L, Hovenkamp E, Korjamo T, Masungi C, Maubon N, Mols R, Müllertz A, Mönkkönen J, O'Driscoll C, Oppers-Tiemissen HM, Ragnarsson EG, Rooseboom M, Ungell AL., Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories Eur. J. Pharm 35, 5, 383-396
Maher S, Brayden DJ, Feighery L, McClean S. Cracking the junction: update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs. Crit Rev Ther Drug Carrier Syst. 25, 2, 117-168
McMahon A, Gomez E, Donohue R, Forde D, Darcy R and O’Driscoll CM, Cyclodextrin gene vectors: cell trafficking and the influence of lipophilic chain length, J. Drug Del. Sci. Tech, 18, 5, 303-307
O’Driscoll CM, Delivery of siRNA: challenges and opportunities, J. Pharm. Pharmacol, 60, Supplement 1, A74
O’Driscoll CM and Griffin BT, Biopharmaceutical challenges associated with drugs with low aqueous solubility - the potential impact of lipid-based formulations, Advance Drug Delivery Reviews, 60 617-624
Ryan SM, Mantovani G, Wang X, Haddleton DM, Brayden DJ. Advances in PEGylation of important biotech molecules: delivery aspects, Drug Deliv., 5, 4, 371-383