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Institut National de la Recherche Agronomique (INRA), France


The 'Adipose Tissue and Milk Lipids' team ( of the Herbivore Research Unit of the 'Institut National de la Recherche Agronomique' (, is involved in Lipgene as a partner in the Animal Nutrition research programme (Workpackage 3.13. Mammary lipid metabolism).

The Directors of the team is Doctor Yves Chilliard ( ) and the principal scientists mainly involved in Lipgene programme are: Christine Leroux ( ), Laurence Bernard ( ), Anne Ferlay and Jacques Rouel, and one PhD student: Séverine Ollier. The team collaborate with GPL-GEL team (Patrice Martin) of INRA (Jouy-en-Josas) for genomic analyses of Lipgene.
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Research Themes

The aim of the team "Adipose Tissue and Milk Lipids" is to study the nutritional and physiological factors controlling plasma leptin, the metabolism of adipose tissue and mammary gland, and the secretion and the composition of milk lipids, in order to improve nutritional, sensorial or technological qualities of ruminant milk and meat. Our research activities are orientated to study the effects of the nature of forage (grass vs. corn ensilage) and of lipid supplementation (different types of oils, and raw or processed oilseeds) on milk fat content and fatty acids composition of bovine and caprine butter or cheese. The effects of nutrients on the regulation of lipogenesis (transcripts and enzymatic activities) and on gene expression (global analyses of transcriptome) in the mammary gland of the lactating goat are also studied. In vitro approaches are being developed to examine the regulation (by nutrients) of gene expression in mammary epithelial cells.
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Selected publications on mammary metabolism and on milk composition

  • Bernard L, Leroux C, Hayes H, Gautier M, Chilliard Y, Martin P. Characterization of the caprine stearoyl-CoA desaturase gene and mRNA showing an unusually long 3'-UTR sequence arising from a single exon. Gene. 2001, 281: 53-61
  • Chilliard Y, Ferlay A, Rouel J, Lamberet G. A review of nutritional and physiological factors affecting goat milk lipid synthesis and lipolysis. J. Dairy Sci. 2003, 86: 1751-1770
  • Chilliard Y, Ferlay A, Doreau M. Effect of different types of forages, animal fat or marine oils in cow's diet on milk fat secretion and composition, especially conjugated linoleic acid (CLA) and polyunsaturated fatty acids. Livest. Prod. Sci. 2001, 70: 31-48
  • Chilliard Y, Ferlay A, Mansbridge RM, Doreau M. Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Ann. Zootech. 2000, 49: 181-205
  • Leroux C, Le Provost F, Petit E, Bernard L, Chilliard Y, Martin P. Real-time RT-PCR and cDNA macroarray to study the impact of the genetic polymorphism at the αS1-casein locus on the expression of genes in the goat mammary gland during lactation. Reprod. Nutr. Develop. 2003, 43: 459-469

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