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Jagiellonian University Medical College

Contact details:
Prof. Aldona Dembinska-Kiec MD PhD
Department of Clinical Biochemistry
Jagiellonian University Medical College
Kopernika 15 a
31-501 Krakow (Poland)
Phone: +48 12 421 4006
Fax: +48 12 421 40 73
E-mail: mbkiec@cyf-kr.edu.pl

Scientific profile

The Department of Clinical Biochemistry the structural unit of Medical Faculty of Medical College (www.cm-uj.krakow.pl), Jagiellonian University of Kraków provides the basis for scientific research and clinical studies and teaching for medical students and postgraduate physicians, from both East and West of Europe. The University in Kraków (www.uj.edu.pl) also includes also the Medical School for Foreigners.

The main research of the Department concentrates on genetic and metabolic changes leading to the pathology of the vessel wall and metabolic disorders related to atherosclerosis, dyslipidemia, and diabetes. Of particular interest is the fatty acid derivative mediated regulation of genes involved in the regulation of human vessel wall cell (including progenitor cells) proliferation, differentiation and apoptosis in the process of angiogenesis and adipogenesis.
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The Department consists of the laboratory of Molecular Biology (PCR, DNA sequencing), the Cell Culture Unit, the Clinical Biochemistry (ELISA, electrophoresis, ultracentrifugation), the Lipid Disorders Lab, and Radioactive Unit (RIA, radiolabelling).

Prof. Dembinska-Kiec MD. PhD spent several years in Germany as a holder of the Alexander von Humboldt Scholarship, in England, working in the Research Department of Welcome Company with the group of Sir John Vane (the Nobel Prize 1983) and Prof. Salvador Moncada (prostanoids, nitric oxide and vessel wall).

As the Vice-President of the Polish Angiological Society and Vice-President of Polish Atherosclerosis Society, she has access to all programs and activities of these societies. In 1993-1997 she was the Vice-Rector of the Medical College, Jagiellonian University of Kraków. She manages 9 grants of the State Committee for Scientific Research of Poland (KBN). She is a member of the international scientific programs: INCO-COPERNICUS, POLONIUM. Prof. Dembinska-Kiec is the member of EC COST-918 Actions: Body Weight and Energy Expenditure, Functional Food and Energy Expenditure. as well as COST- 17B; Insulin resistance, obesity and diabetes mellitus in the eldery.

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Since 2002 Prof. Dembinska-Kiec his also the coordinator of the 5th FP acronym DLARFID "Dietary lipids as Risk Factors in Development. Mechanistic Issues QLK1-CT-2001-00183 (www.dlarfid.org) and the co-coordinator of the 5th FP acronym STEC (Stem Cell Excellence Centre) QLK3-CT-2002-30307, 00183 (www.stemcell.org.pl). She is also involved as a partner of the European Nutrigenomics Organisation Nu-GO FP-6 2002-FOOD 506360 (www.nugo.org): as well as the FP 6 -2002-LIFESCIHEALTH-502988: "Application and process optimization of human stem cells for myocardium repair" acronim SC&CR.

Profesor Dembinska-Kiec is an author of about 260 original articles, 4 books, 30 book chapters, multiple reviews, abstracts or commentaries.
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Other information

This group has experience in the in vitro and in vivo model of angiogenesis, and the fatty acid-derivative and RXR/PPARs regulated expression of genes, markers of inflammation, proliferation and apoptosis (iNOS, eNOS, VEGF, Jagged/Notch, IAP etc). Special attention is paid on the role of the PPAR-regulated expression of the cell-to-cell adhesion molecules (Jagged/Notch) in proliferation and differentiation of premature progenitors of endothelial and other proliferating cell events, important for an inhibition of tumour growth.

The group has significant expertise in clinical, biochemical and molecular techniques relevant for the study of the process of angiogenesis such as clinical examinations, tissue culture, lipid biochemistry and molecular biology techniques.

View Important Publications here.

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