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Lipgene

University of Oslo

The Department of Nutrition (www.nutrition.uio.no/english), Institute of Basic Medical Sciences, University of Oslo, is involved in Lipgene both as a partner and as workpackage leader of workpackage 1.3 Mechanistic and Functional Studies.
Research topics in our department include the regulation of gene expression by nutrients such as retinoids, antioxidants, cholesterol and fatty acids on molecular, cellular as well as whole body levels.

We use all the common techniques in modern molecular biology including transfection of genes in cells and animals (transgenic mice). In particular some transgenic mice strains have been developed with promoter sequences for important transcription factor (eg NFκB) linked to the gene encoding luciferase. Activation of luciferase may promote emission of light which can be monitored by a light-sensitive videocamera. Thus, gene activation due to nutritional or other factors can be examined in vivo.
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There is an extensive focus on factors influencing lipid homeostasis related to obesity, diabetes, cachexia, cardiovascular diseases and osteoporosis, with evaluation on how nutrients influence gene regulation of nuclear receptors like peroxisome proliferator activated receptors (PPARs), liver x receptors (LXRs) and sterol regulating element binding protein (SREBP).

Glycobiology is another topic where the focus is on proteoglycans in relation to diabetes. We also explore possible biomarkers for the intake of foods believed to affect human health.
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Another research group in our department is focused on the importance of essential fatty acids (DHA and AA) supplements to premature infants fed human milk and their effects on growth and development.

We also investigate the consolidation and development of dietary habits related to age (from childhood via adolescence, adulthood and old age), social status, educational level and its nutritional implications, as well as nutritional factors relating to reproductive health, including HIV/AIDS.

We have the national food data base in Norway and perform extensive studies related to food and nutrient intake in different populations.

In addition, we have extensive expertise within the area of highly automated chromatographic (gas and liquid) analyses detecting the analytes with spectrometry, fluoremetry, flame ionisation (FID), electron capture and mass spectrometry.

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