The Hospital currently provides specialist services in Substance Misuse, Psychotic Disorders, Eating Disorders, Psychiatry of Later Life and Adolescent Disorders. The Hospital is affiliated with University College Dublin, Trinity College Dublin, Dublin City University and the University of Limerick for undergraduate and postgraduate healthcare professional programmes. An extensive clinical research programme operates throughout the Order's Mental Health Services.

Saint John of God Hospital retains a leadership role in developing innovative and effective treatment programmes for people suffering from mental health problems. Referrals are accepted nationally and internationally. While providing excellent clinical treatment and care to patients and their families, the hospital is committed to training healthcare professionals and to conducting clinical research designed to enhance treatment programmes to improve outcomes for patients and the overall enhancement of their quality of life.