Research Publications

Recent Publications

2018

  • Friedman AN, Wahed AS, Wang J, Courcoulas AP, Dakin G, Hinojosa MW, Kimmel PL, Mitchell JE, Pomp A, Pories WJ, Purnell JQ, le Roux C, Spaniolas K, Steffen KJ, Thirlby R, Wolfe B. Effect of Bariatric Surgery on CKD Risk. J Am Soc Nephrol. 2018 Jan 15. pii: ASN.2017060707. doi: 10.1681/ASN.2017060707. [Epub ahead of print] PubMed PMID: 29335242.
  • Mingrone G, Bornstein S, Le Roux CW. Optimisation of follow-up after metabolic surgery. Lancet Diabetes Endocrinol. 2018 Jan 29. pii: S2213-8587(17)30434-5. doi: 10.1016/S2213-8587(17)30434-5. [Epub ahead of print] Review. PubMed PMID:29396249.
  • Brennan EP, Mohan M, McClelland A, Tikellis C, Ziemann M, Kaspi A, Gray SP, Pickering R, Tan SM, Ali-Shah ST, Guiry PJ, El-Osta A, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P. Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.J Am Soc Nephrol. 2018 Feb 28. pii: ASN.2017101112. doi: 10.1681/ASN.2017101112. [Epub ahead of print].

 

2017

  • Arora T, Seyfried F, Docherty N.G, le Roux C.W, Perkins R, Bäckhed F Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass International Society of Microbial Ecology Journal (ISME) 2017. 11(9):2035-2046 201.
  • Borgeson E, Wallenius, Syed, GH Darshi, M Rodriguez JL Bioresrud C Ragnmark Ek M Bjorklund P, Quiding-Jabrink, M Fandriks L Godson C* Sharma, K High-fat diet-induced pathophysiology is reduced by AICAR in an adiponectin-independent manner Diabetalogia 2017 Apr;60(4):729-739.
  • Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L. Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity Immunity. 2017 Feb 21;46(2):273-286. PMID: 28228283.
  • Brennan E, Wang B, McClelland A, Mohan M, Marai M, Beuscart O, Derouiche S, Gray S, Pickering R, Tikellis C, de Gaetano M, Barry M, Belton O, Ali-Shah ST, Guiry P, Jandeleit-Dahm KAM, Cooper ME, Godson C, Kantharidis P. Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis. Diabetes. 2017 Aug;66(8):2266-2277.
  • Brennan EP, Cacace A, Godson C. Specialized pro-resolving mediators in renal fibrosis. Mol Aspects Med. 2017 May 11.
  • Bruen R, Curley S, Kajani S, Crean D, O'Reilly ME, Lucitt MB, Godson CG, McGillicuddy FC, Belton O. Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis. Cardiovasc Diabetol. 2017 Nov 6;16(1):143-156.
  • Bruen R, Fitzsimons S, Belton O. Atheroprotective effects of conjugated linoleic acid. Br J Clin Pharmacol. 2017 Jan;83(1):46-53.
  • Cohen R, Le Roux CW, Junqueira S, Ribeiro RA, Luque A. Roux-En-Y Gastric Bypass in Type 2 Diabetes Patients with Mild Obesity: a Systematic Review and Meta-analysis. Obes Surg. 2017 Aug 7.
  • Cohen RV, Luque A, Junqueira S, Ribeiro RA, Le Roux CW. What is the impact on the healthcare system if access to bariatric surgery is delayed? Surg Obes Relat Dis. 2017 Sep;13(9):1619-1627. doi: 10.1016/j.soard.2017.03.025. Epub 2017 Mar 31. PMID: 28499887.
  • Cummins EP, Crean D. 'Hypoxia and Inflammatory Bowel Disease.' Microbes and infection. 2017; 19(3):210-21.
  • DeChiara L., Andrews D., Watson A., Oliviero G.,  Cagney G. and Crean J. miR302 regulates SNAI1 expression to control mesangial cell plasticity Scientific Reports, 2017, in press.
  • Docherty N.G, Fändriks L, le Roux C.W, Hallesrund P, Werling M. Urinary Sodium Excretion after Gastric Bypass Surgery Surgery for Obesity and Related Diseases (SOARD)  13(9):1506-1514 2017.
  • Doody A, Jackson, S, Elliott JA, Canavan R, Godson C, Slattery D, Twomey P, McKenna M, le Roux CW, Docherty NG 1Validating the Association between Plasma Tumour Necrosis Factor Receptor 1 Levels and the Presence of Renal Injury and Functional Decline in Patients with Type 2 Diabetes Journal of Diabetes & its Complications 2017 [Epub ahead of print].
  • Elliott JA, Docherty N.G, Eckhardt HG, Doyle SL, Guinan EM, Ravi N, Reynolds JV, Roux CW. Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study. Annals of  Surgery  266(1):82-90 2017.
  • Higgins DF, Ewart LM, Masterson E, Tennant S, Grebnev G, Prunotto M, Pomposiello S, Conde-Knape K, Martin FM, Godson C. BMP7-induced-Pten inhibits Akt and prevents renal fibrosis. Biochim Biophys Acta. 2017 Sep 18;1863(12):3095-3104.
  • Hyde KM, Blonde GD, le Roux CW, Spector AC. Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection. Physiol Behav. 2017 Aug 1;177:4-12.
  • Laurenius A, Werling M, le Roux CW, Fändriks L, Olbers T. Dumping symptoms is triggered by fat as well as carbohydrates in patients operated with Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2017 Jul;13(7):1159-1164.
  • le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DC, Van Gaal L, Ortiz RV, Wilding JP, Skjøth TV, Manning LS, Pi-Sunyer X; 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. SCALE Obesity.; Prediabetes NN8022-1839 Study Group. Lancet. 2017 Feb 22. pii: S0140-6736(17)30069-7.
  • MacLellan GA, Dunlevy C, O'Malley E, Blake C, Breen C, Gaynor K, Wallace N, Yoder R, Casey D, Mehegan J, O'Shea D, Fullen BM. Musculoskeletal pain profile of obese individuals attending a multidisciplinary weight management service Pain. 2017 Apr 5.
  • Marcone S, Belton O, Fitzgerald DJ. Milk-derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis. Br J Clin Pharmacol. 2017 Jan;83(1):152-162.
  • Mazzei L, Cuello-Carrión FD, Docherty NG, Manucha W. Heat shock protein 70/nitric oxide effect on stretched tubular epithelial cells linked to WT-1 cytoprotection during neonatal obstructive nephropathy. Int Urol Nephrol. 2017 [Epub ahead of print].
  • McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP, Crean D. NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells. Front Immunol. 2017 Jan 23;8:7.
  • Miras AD, Herring R, Vusirikala A, Shojaee-Moradi F, Jackson NC, Chandaria S, Jackson SN, Goldstone AP, Hakim N, Patel AG, Umpleby AM, Le Roux CW. Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans. Obes Sci Pract. 2017 Mar;3(1):95-98.
  • Miras AD, le Roux CW. Metabolic Surgery in a Pill. Cell Metab. 2017 May 2;25(5):985-987.
  • Neff K.J,  Elliott J.A, Jackson S.N,   Corteville C,  Abegg K, Godson C, , Boza C,  Lutz T.A,  Docherty N.G,  le Roux C.W.  Effect of Roux-en-Y Gastric Bypass and Diet induced Weight Loss on Diabetic Kidney Disease in the Zucker Diabetic Fatty Rat Surgery for Obesity and Related Diseases (SOARD) 13(1):21-27 2017.
  • Nielsen MS, Christensen BJ, Ritz C, Rasmussen S, Hansen TT, Bredie WLP, le Roux CW, Sjödin A, Schmidt JB. Roux-En-Y Gastric Bypass and Sleeve Gastrectomy Does Not Affect Food Preferences When Assessed by an Ad libitum Buffet Meal. Obes Surg. 2017 Apr 14.
  • O'Neill KN, Finucane FM, le Roux CW, Fitzgerald AP, Kearney PM. Unmet need for bariatric surgery. Surg Obes Relat Dis. 2017 Jun;13(6):1052-1056. doi: 10.1016/j.soard.2016.12.015. Epub 2016 Dec 23. PMID: 28256395.
  • Ooi GJ, Doyle L, Tie T, Wentworth JM, Laurie C, Earnest A, Cowley MA, Sikaris K, le Roux CW, Burton PR, O'Brien PE, Brown WA. Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components. Int J Obes (Lond). 2017 Jun;41(6):902-908.
  • Risstad H, Kristinsson JA, Fagerland MW, le Roux CW, Birkeland KI, Gulseth HL, Thorsby PM, Vincent RP, Engström M, Olbers T, Mala T. Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial. Surg Obes Relat Dis. 2017 Sep;13(9):1544-1553.
  • Taha O, Hussein A, Abdelaal M, al-Najim W, le Roux CW, Docherty NG Impact of abdominal subcutaneous fat reduction on glycemic control in obese patients with type 2 diabetes mellitus Bariatric Surgical Practice and Patient Care 2017 in press.
  • Tang T, Abbott S, le Roux CW, Wilson V, Singhal R, Bellary S, Tahrani A. Preoperative Weight Loss With GLP-1 Receptor Agonist Treatment Predicts Greater Weight Loss Achieved by the Combination of Medical Weight Management And Bariatric Surgery In Patients With Type 2 Diabetes: A Longitudinal Analysis. Diabetes Obes Metab. 2017 Oct 20. doi: 10.1111/dom.13131. Epub ahead of print] PMID: 29053203.

 

2016

  • Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J. Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45.
  • Cavadas MAS, Mesnieres M, Crifo B, Cabrero Manresa M, Selfridge,AC  Fabian Z, Scholz CC, Nolan KA, Rocha LA, Tambuwala MM, Brown S, Wdowicz A, Corbett D, Murphy KJ, Godson C, Cummins EP, TaylorCT, Cheong A REST is a hypoxia-inducible repressor of transcription  Sci Reports 2016.
  • Coluzzi I, Raparelli L, Guarnacci L, Paone E, Del Genio G, le Roux CW, Silecchia G. Food Intake and Changes in Eating Behavior After Laparoscopic Sleeve Gastrectomy. Obes Surg. 2016 Jan 7. [Epub ahead of print] PMID: 26744284.
  • Connaughton RM, McMorrow AM, McGillicuddy FC, Lithander FE, Roche HM. Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood. Proc Nutr Soc 75(02):115-124, 2016.
  • Cummins EP, Keogh CE, Crean D, Taylor CT. 'The Role of HIF in Immunity and Inflammation.' Mol Aspects Med. 2016; 47-48:24-34.
  • De Chiara L, Crean J. Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the Kidney. J Clin Med. 2016 Jan 12; 5(1). pii: E6. doi: 10.3390/jcm5010006.
  • de Gaetano M, Crean D, Barry M, Belton O. M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis. Front Immunol. 2016 Jul 19;7:275. doi: 10.3389/fimmu.2016.00275.
  • Dutia R, Embrey M, O'Brien S, Haeusler RA, Agénor KK, Homel P, McGinty J, Vincent RP, Alaghband-Zadeh J, Staels B, le Roux CW, Yu J, Laferrère B. Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes. Int J Obes (Lond). 2016 Mar;40(3):554.
  • Elliott JA, le Roux CW. Type 2 diabetes with BMI<30 kg/m2: Can we predict success of metabolic surgery? Surg Obes Relat Dis. 2016 Mar 16. pii: S1550-7289(16)00102-7. doi: 10.1016/j.soard.2016.03.012. PMID: 27130137.
  • Gaul D, Mat A, O'Shea D, Issartel J. Impaired Visual Motor Coordination in Obese Adults., J Obes. 2016;2016:6178575. Epub 2016 Nov 22. PMID: 27994885.
  • Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, Fitzgerald RJ, Roche HM. A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome‐mediated inflammation and improving insulin signaling.  Mol Nutr Food Res 2016.
  • Hunt KF, Dunn JT, le Roux CW, Reed LJ, Marsden PK, Patel AG, Amiel SA. Differences in Regional Brain Responses to Food Ingestion After Roux-en-Y Gastric Bypass and the Role of Gut Peptides: A Neuroimaging Study. Diabetes Care. 2016 Oct;39(10):1787-95. doi: 10.2337/dc15-2721. PMID: 27660120.
  • Jung J, Ha TK, Lee J, Lho Y, Nam M, Lee D, le Roux CW, Ryu DH, Ha E, Hwang GS. Changes in one-carbon metabolism after duodenal-jejunal bypass surgery. Am J Physiol Endocrinol Metab. 2016 Jan 19:ajpendo.00260.2015.
  • le Roux C.W, Engstrom M,, Bjornfot N,, Fandriks L, Docherty N.G Equivalent Increases in Circulating GLP-1 Following Jejunal Delivery of Intact and Hydrolysed Casein: Relevance to Satiety Induction Following Bariatric Surgery. Obesity surgery 26(8):1851-8 2016.
  • Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O'Shea D, Brenner M. iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metab. 2016 Sep 13;24(3):510-9.PMID: 27593966.
  • Lyons CL, Kennedy EB, Roche HM, 2016. Metabolic Inflammation-Differential Modulation by Dietary Constituents. Nutrients, 8(5):247, 2016.
  • Maghsoodi N, Alaghband-Zadeh J, Cross G, Werling M, Fandriks L, Docherty NG, Olbers T, Dew T, Sherwood R, Vincent R.P, Le Roux C.W. Elevated Fasting & Post-prandial C-Terminal Telopeptide (CTX) after Roux-en-Y gastric bypass (RYGB). Ann Clin Biochem. 54(4):495-500 2016.
  • Mathes CM, Letourneau C, Blonde GD, le Roux CW, Spector AC. Roux-en-Y Gastric Bypass in Rats Progressively Decreases the Proportion of Fat Calories Selected from a Palatable Cafeteria Diet. Am J Physiol Regul Integr Comp Physiol. 2016 Feb 10:ajpregu.00444.2015.
  • McDarby F, O'Hora D, O'Shea D, Byrne M. Pediatr Obes. Taking the sweetness out of the 'Share a Coke' marketing campaign: the influence of personalized labelling on elementary school children's bottled drink choices 2016 Nov 24. doi: 10.1111/ijpo.12193. PMID: 27884050.
  • McKay, G., Kavanagh, D., Crean, J., Maxwell, A.P. Bioinformatic evaluation of transcriptional regulation of WNT pathway genes with reference to diabetic nephropathy. Journal of Diabetes Research, 2016:7684038. doi: 10.1155/2016/7684038.
  • McKenna I, Hughes S, Barnes-Holmes D, De Schryver M, Yoder R, O'Shea D. Obesity, food restriction, and implicit attitudes to healthy and unhealthy foods: Lessons learned from the implicit relational assessment procedure. Appetite. 2016 May 1;100:41-54. doi: 10.1016/j.appet.2016.02.013. Epub 2016 Feb 11. PMID: 2687721
  • Mossberg KE, Pournaras DJ, Welbourn R, le Roux CW, Brogren H. Differential response of plasma plasminogen activator inhibitor 1 after weight loss surgery in patients with or without type 2 diabetes. Surg Obes Relat Dis. 2016 Mar 14. PMID: 27387691.
  • Neff KJ, Baud G, Raverdy V, Caiazzo R, Verkindt H, Noel C, le Roux CW, Pattou F. Renal Function and Remission of Hypertension After Bariatric Surgery: a 5-Year Prospective Cohort Study. Obes Surg. 2016 Sep 14. PMID: 27628054.
  • Neff KJ, le Roux CW. Bariatric surgery: traversing the CROSSROADS into mainstream diabetes care. Diabetologia. 2016 May;59(5):942-4. doi: 10.1007/s00125-016-3928-1. Epub 2016 Mar 16. No abstract available. PMID: 26983923.
  • O’Reilly M, Dillon E, Guo W, Finucane O, McMorrow A, Murphy A, Lyons C, Jones D, Ryan M, Gibney M, Gibney E, Brennan L, de la Llera Moya M, Reilly M.P, Roche H M, McGillicuddy FC. High-Density Lipoprotein Proteomic Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets.  Circulation 133, 1838-1850, 2016. DOI: 10.1161/CIRCULATIONAHA.115.020278. 
  • O’Sullivan S, Jun Wang J , Docherty N.G, , Noreen Boyle2 Kana-Lis S, Gilmer J, Medina C. Inhibition of Matrix Metalloproteinase-9 by a Barbituate-Nitrate Hybrid Ameliorates Dextran Sulphate Sodium-Induced Colitis-Effect on Inflammation Related Genes British Journal of Pharmacology 174(7):512-524 2016.
  • Oliverio G., O’Brien GL, Watson A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Bracken A, Crean J, Cagney G. Dynamic Protein interactions of the Polycomb Repressive Complex 2 during differentiation of pluripotent cells. Molecular and Cellular Proteomics, 2016. doi: 10.1074/mcp.M116.062240.
  • Pournaras DJ, Hardwick RH, le Roux CW. Gastrointestinal surgery for obesity and cancer: 2 sides of the same coin. Surg Obes Relat Dis. 2016 Dec 23. pii: S1550-7289(16)30878-4. doi: 10.1016/j.soard.2016.12.014. [Epub ahead of print] PMID: 28161354.
  • Pournaras DJ, Nygren J, Hagström-Toft E, Arner P, le Roux CW, Thorell A. Improved glucose metabolism after gastric bypass: evolution of the paradigm. Surg Obes Relat Dis. 2016 Mar 23. PMID: 27387696
  • Qvigstad E, Gulseth HL, Risstad H, le Roux CW, Berg TJ, Mala T, Kristinsson JA. A novel technique of Roux-en-Y gastric bypass reversal for postprandial hyperinsulinemic hypoglycaemia: A case report. Int J Surg Case Rep. 2016 Feb 27;21:91-94. doi: 10.1016/j.ijscr.2016.02.033. PMID: 26957187.
  • van Avesaat M, Troost FJ, Westerterp-Plantenga MS, Helyes Z, le Roux CW, Dekker J, Masclee AA, Keszthelyi D. Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones. Am J Clin Nutr. 2016 Feb;103(2):305-13.
  • Wang B, Yao K, Huuskes BM, Shen H-H, Zhuang J, Godson C, Brennan EP, Wilkinson-Berka JL, Wise AF, Ricardo SD. Mesenchymal stem cells deliver exogenous microRNA let7c via exosomes to attenuate renal fibrosis Mol. Ther.  Aug;24(7):1290-30 2016.
  • Welbourn R, Dixon J, Barth JH, Finer N, Hughes CA, le Roux CW, Wass J; Guidance Development Group. NICE-Accredited Commissioning Guidance for Weight Assessment and Management Clinics: a Model for a Specialist Multidisciplinary Team Approach for People with Severe Obesity. Obes Surg. 2016 Jan 6. [Epub ahead of print] PMID: 26738895.
  • Welbourn R, le Roux CW, Owen-Smith A, Wordsworth S, Blazeby JM. Why the NHS should do more bariatric surgery; how much should we do? BMJ. 2016 May 11;353:i1472. doi: 10.1136/bmj.i1472. PMID: 27169605.
  • Wilding JP, Overgaard RV, Jacobsen LV, Jensen CB, le Roux CW. Exposure-response analyses of liraglutide 3.0 mg for weight management. Diabetes Obes Metab. 2016 Feb 2. doi: 10.1111/dom.12639. [Epub ahead of print] PMID: 26833744.
  • Zanchi D, Meyer-Gerspach AC, Suenderhauf C, Janach K, le Roux CW, Haller S, Drewe J, Beglinger C, Wölnerhanssen BK, Borgwardt S. Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels. Sci Rep. 2016 Oct 20;6:35727.

 

2015

  • Chuah LL, Miras AD, Papamargaritis D, Jackson SN, Olbers T, le Roux CW. Impact of perioperative management of glycemia in severely obese diabetic patients undergoing gastric bypass surgery. Surg Obes Relat Dis. 2015 May-Jun;11(3):578-84. doi: 10.1016/j.soard.2014.11.004. Epub 2014 Nov 13. PMID: 25863535.
  • Abegg K, Corteville C, Docherty N.G, Boza C, Lutz T.A, Muñoz R, le Roux C.W. Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 15;308(4):R321-329. 2015.
  • Alsters SI, Goldstone AP, Buxton JL, Zekavati A, Sosinsky A, Yiorkas AM, Holder S, Klaber RE, Bridges N, van Haelst MM, le Roux CW, Walley AJ, Walters RG, Mueller M, Blakemore AI. Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism. PLoS One. 2015 Jun 29;10(6):e0131417.
  • Arora T, Velagapudi V, Pournaras DJ, Welbourn R, le Roux CW, Orešič M, Bäckhed F. Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission. PLoS One. 2015 May 6;10 (5):e0126401. doi: 10.1371/journal.pone.0126401. eCollection 2015. PMID: 25946120.
  • Belgaumkar AP, Vincent RP, Carswell KA, Hughes RD, Alaghband-Zadeh J, Mitry RR, le Roux CW, Patel AG. Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease. Obes Surg. 2015 Sep 4. [Epub ahead of print] PMID: 26337697.
  • Borgeson E, Johnston,A  Lee, YS, Till,A Syed, GH Ali Shah, T, Guiry PJ, Dalli, J Colas,R Serhan, CN, Sharma, K and Godson C.  Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease. Cell Metab. 2015 Jul 7;22(1):125-3.
  • Boxwell AJ, Chen Z, Mathes CM, Spector AC, le Roux CW, Travers SP, Travers JB. Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus. Physiol Behav. 2015 Dec 1;152(Pt B):329-39.
  • Breen C, Ryan M, Gibney MJ, O'Shea D. Diabetes-related nutrition knowledge and dietary intake among adults with type 2 diabetes. Br J Nutr. 2015 Aug 14;114(3):439-47.
  • Carolan E, Tobin LM, Mangan BA, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter DC, Doherty DG, Lynch L, O'Shea D, Hogan AE. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity  J Immunol. 2015 Jun 15;194(12):5775-80.
  • Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP. 'Adenosine Modulates NR4A Orphan Nuclear Receptors to Attenuate Hyperinflammatory Responses in Monocytic Cells.' J Immunol. 2015; 195(4):1436-48.
  • de Gaetano M, Alghamdi K, Marcone S, Belton O. Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation. J Inflamm (Lond). 2015 Feb 19;12:15. doi: 10.1186/s12950-015-0060-9. eCollection 2015.
  • de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Bouvy ND, Greve JW. Impact of Duodenal-Jejunal Exclusion on Satiety Hormones. Obes Surg. 2015 Oct 7. [Epub ahead of print] PMID: 26446491.
  • Del Genio G, Gagner M, Limongelli P, Tolone S, Pournaras D, le Roux CW, Brusciano L, Licia Mozzillo A, Del Genio F, Docimo L. Remission of type 2 diabetes in patients undergoing biliointestinal bypass for morbid obesity: a new surgical treatment. Surg Obes Relat Dis. 2015 Dec 7. pii: S1550-7289(15)01093-X. doi: 10.1016/j.soard.2015.12.003. [Epub ahead of print] PMID: 27150339.
  • Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O'Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P. Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells. Br J Pharmacol. 2015 172(18): 4575-4587.
  • Elliott JA, Jackson S, King S, McHugh R, Docherty N.G, Reynolds J.V, le Roux C.W.  Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction. Annals of Surgery 262: 824-829; discussion 829-830 2015.
  • Finucane OM, Lyons CL, Murphy AM, Reynolds CM, … Tierney AC, Morine MJ, Alcala-Diaz JF, Lopez-Miranda J, O'Connor DP, O'Neill LA, McGillicuddy FC, Roche HM. Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity. Diabetes. 64(6):2116-28, 2015.
  • Gaoatswe G, Kent BD, Corrigan MA, Nolan G, Hogan AE, McNicholas WT, O'Shea D. Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. Sleep. 2015 Oct 1;38(10):1629-34.
  • Goldstone AP, Miras AD, Scholtz S, Jackson S, Neff KJ, Pénicaud L, Geoghegan J, Chhina N, Durighel G, Bell JD, Meillon S, le Roux CW. Link between increased satiety gut hormones and reduced food reward following gastric bypass surgery for obesity. J Clin Endocrinol Metab. 2015 Nov 18:jc20152665. [Epub ahead of print] PMID: 26580235.
  • Jennings P, Crean D, Aschauer L, Limonciel A, Moenks K, Kern G, Hewitt P, Lhotta K, Lukas A, Wilmes A, Leonard MO. 'Interleukin-19 as a Translational Indicator of Renal Injury.' Arch Toxicol. 2015; 89(1):101-6.
  • Lavelle A, Lennon G, O'Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy H.E, Doherty G, O'Donoghue D, Hyland J, Ross R.P, Coffey J.C, Sheahan K, Cotter P.D, Shanahan F, Winter D.C, O'Connell PR. Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers. Gut. 64(10):1553-61.2015.
  • Locke AE, Genetic studies of body mass index yield new insights for obesity biology Nature. 2015 Feb 12;518(7538):197-206.
  • Maguire PJ, Power KA, O'Higgins AC, Jackson S, Harley R, le Roux CW, Turner MJ. Maternal C-reactive protein in early pregnancy. Eur J Obstet Gynecol Reprod Biol. 2015 Oct;193:79-82.
  • Marcantoni E, Dovizio M, O Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O  Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1. Prostaglandins Other Lipid Mediat. 2015 Mar 26.
  • Marcone S, Haughton K, Simpson PJ, Belton O, Fitzgerald DJ. Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB.J Inflamm (Lond). 2015 Jan 20;12(1):1. doi: 10.1186/s12950-014-0044-1. eCollection 2015.PMID: 25632270.
  • Mathes CM, Bohnenkamp RA, Blonde GD, Letourneau C, Corteville C, Bueter M, Lutz TA, le Roux CW, Spector AC. Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat. Physiol Behav. 2015 Apr 1;142:179-88.
  • Mathes CM, Bohnenkamp RA, le Roux CW, Spector AC. Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R864-74.
  • McMorrow AM, Connaughton RM, Lithander FE, Roche HM. Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality. Proc Nutr Soc. 74(01):67-82, 2015.
  • Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, et al. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 114(07): 999-1012, 2015. DOI: 10.1017/S0007114515002093 (IF:3.311; C:31).
  • Miras AD, Chuah LL, Khalil N, Nicotra A, Vusirikala A, Baqai N, Graham C, Ravindra S, Lascaratos G, Oliver N, le Roux CW. Type 2 diabetes mellitus and microvascular complications 1 year after Roux-en-Y gastric bypass: a case-control study. Diabetologia. 2015 Jul;58(7):1443-7. doi: 10.1007/s00125-015-3595-7.
  • Murphy EP, Crean D. 'Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-kappaB are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis.' Biomolecules. 2015; 5(3):1302-18.
  • Nolan KA, Brennan EP, Scholz CC, Cullen C, Ryan A, Taylor CT, Godson C*. Paricalcitol protects against TGF-β1-induced fibrotic responses in hypoxia and stabilises HIF-α in renal epithelia. Exp Cell Res. 2015 Jan 15;330(2):371-81.
  • O'Connor E, Green S, Kiely C, O'Shea D, Egaña M. Differential effects of age and type 2 diabetes on dynamic vs. peak response of pulmonary oxygen uptake during exercise. J Appl Physiol (1985). 2015 Apr 15;118(8):1031-9. PMID: 25701005.
  • Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP; SCALE Obesity and Prediabetes NN8022-1839 Study Group. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. New England Journal Medicine. 2015 Jul 2;373(1):11-22.
  • Pournaras DJ, le Roux CW. Type 2 diabetes: multimodal treatment of a complex disease. Lancet. 2015 Sep 5;386(9997):936-7. doi: 10.1016/S0140-6736(15)00132-4.PMID: 2636945.
  • Quill B, Irnaten M, Docherty N.G, McElnea E.M, Wallace D.M, Clark A.F, O'Brien C.J. Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells. Br J Ophthalmol. 99(7):1009-14 2015.
  • Risstad H, Søvik TT, Engström M, Aasheim ET, Fagerland MW, Olsén MF, Kristinsson JA, le Roux CW, Bøhmer T, Birkeland KI, Mala T, Olbers T. Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial. JAMA Surg. 2015 Apr;150(4):352-61.
  • Sam AH, Sleeth ML, Thomas EL, Ismail NA, Mat Daud N, Chambers E, Shojaee-Moradie F, Umpleby M, Goldstone AP, le Roux CW, Bech P, Busbridge M, Laurie R, Cuthbertson DJ, Buckley A, Ghatei MA, Bloom SR, Frost GS, Bell JD, Murphy KG. Circulating pancreatic polypeptide concentrations predict visceral and liver fat content. J Clin Endocrinol Metab. 2015 Mar;100(3):1048-52.
  • Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Courts FL, Pechlivanis A, Gooderham NJ, Holmes E, le Roux CW, Atkin SL. Aspartame sensitivity? A double blind randomised crossover study. PLoS One. 2015 Mar 18;10(3):e0116212. doi: 10.1371/journal.pone.0116212. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0126039.
  • Shungin D New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-96.
  • Somerville R, McKenzie K, Eslami S, Breen C, O'Shea D, Wall P. Poor mental health in severely obese patients is not explained by the presence of comorbidities. Clin Obes. 2015 Feb;5(1):12-21.
  • Spector AC, le Roux CW, Munger SD, Travers SP, Sclafani A, Mennella JA. Proceedings of the 2015 A.S.P.E.N. Research Workshop-Taste Signaling: Impact on Food Selection, Intake, and Health. JPEN J Parenter Enteral Nutr. 2015 Nov 23. pii: 0148607115617438. [Epub ahead of print] PMID: 26598504.
  • Todd JN, Dahlström EH, Salem RM, Sandholm N, Forsblom C; FinnDiane Study Group, McKnight AJ, Maxwell AP, Brennan E, Sadlier D, Godson C, Groop PH, Hirschhorn JN, Florez JC. Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease. Diabetes. 2015 Dec;64(12):4238-46.
  • Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva-Datchary P, Olbers T, Fändriks L, le Roux CW, Nielsen J, Bäckhed F. Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation. Cell Metab. 2015 Aug 4;22(2):228-38.
  • Werling M, Fändriks L, Olbers T, Bueter M, Sjöström L, Lönroth H, Wallenius V, Stenlöf K, le Roux CW. Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake. PLoS One. 2015 Jun 22;10(6):e0129784.
  • Wu Q, Li JV, Seyfried F, le Roux CW, Ashrafian H, Athanasiou T, Fenske W, Darzi A, Nicholson JK, Holmes E, Gooderham NJ. Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery. Int J Obes (Lond). 2015 Jul;39(7):1126-34.

 

2014

  • Ahern T, Khattak A, O'Malley E, Dunlevy C, Kilbane M, Woods C, McKenna MJ, O'Shea D. Association Between Vitamin D Status and Physical Function in the Severely Obese. J Clin Endocrinol Metab. 2014 Apr 15:jc20141704. 
  • Angelopoulos T, Kokkinos A, Liaskos C, Tentolouris N, Alexiadou K, Miras AD, Mourouzis I, Perrea D, Pantos C, Katsilambros N, Bloom SR, le Roux CW. The effect of slow spaced eating on hunger and satiety in overweight and obese patients with type 2 diabetes mellitus. BMJ Open Diabetes Res Care. 2014 Jul 2;2(1).
  • Bächler T, Schiesser M, Lutz TA, le Roux CW, Bueter M. Where to begin and where to end? Preoperative assessment for patients undergoing metabolic surgery. Dig Surg. 2014;31(1):25-32.
  • Bhutta HY, Deelman TE, le Roux CW, Ashley SW, Rhoads DB, Tavakkoli A. Intestinal sweet-sensing pathways and metabolic changes after Roux-en-Y gastric bypass surgery. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G588-93.
  • Breen C, Ryan M, McNulty B, Gibney MJ, Canavan R, O'Shea D. High saturated-fat and low-fibre intake: a comparative analysis of nutrient intake in individuals with and without type 2 diabetes. Nutr Diabetes. 2014 Feb 3;4:e104.
  • Carswell KA, Vincent RP, Belgaumkar AP, Sherwood RA, Amiel SA, Patel AG, le Roux CW. The effect of bariatric surgery on intestinal absorption and transit time. Obes Surg. 2014 May;24(5):796-805.
  • Elias E, Casselbrant A, Werling M, Abegg K, Vincent RP, Alaghband-Zadeh J, Olbers T, le Roux CW, Fändriks L, Wallenius V. Bone mineral density and expression of vitamin D receptor-dependent calcium uptake mechanisms in the proximal small intestine after bariatric surgery. Br J Surg. 2014 Nov;101(12):1566-75. doi: 10.1002/bjs.9626. Epub 2014 Sep 10.
  • Goyale A, Ashley SL, Taylor DR, Elnenaei MO, Alaghband-Zadeh J, Sherwood RA, le Roux CW, Vincent RP. Predicting refeeding hypophosphataemia: Insulin growth factor 1 (IGF-1) as a diagnostic biochemical marker for clinical practice. Ann Clin Biochem. 2014 Mar 7.
  • Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F, Godson C*, Murphy M. IHG-1 increases mitochondrial fusion and bioenergetic function.  Diabetes. 2014 Dec;63(12):4314-25.
  • Jimenez-Gomez Y, Cruz-Teno C, Rangel-Zuñiga OA, Peinado JR, Perez-Martinez P, Delgado-Lista J, Garcia-Rios A, Camargo A, Vazquez-Martinez R, Ortega-Bellido M, Perez-Jimenez F, Roche HM, Malagon MM, Lopez-Miranda J. Effect of  dietary fat modification on subcutaneous white adipose tissue insulin sensitivity in patients with metabolic syndrome. Mol Nutr Food Res Nov;58(11):2177-88, 2014 .
  • Kim JY, Ha TK, le Roux CW. Metabolic effects of gastrectomy with or without omentectomy in gastric cancer. Hepatogastroenterology. 2014 Sep;61(134):1830-4.
  • Laurenius A, Werling M, Le Roux CW, Fändriks L, Olbers T. More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2014 Apr 18. pii: S1550-7289(14)00156-7. doi: 10.1016/j.soard.2014.04.007.
  • Lennon G, Balfe Á, Bambury N, Lavelle A, Maguire A, Docherty N.G, Coffey J.C, Winter D.C, Sheahan K, O'Connell PR. Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis. Colorectal Dis. 16(5):O161-169. 2014.
  • Lyons T, Neff KJ, Benn J, Chuah LL, le Roux CW, Gilchrist M. Body mass index and diabetes status do not affect postoperative infection rates after bariatric surgery. Surg Obes Relat Dis. 2014 Mar-Apr;10(2):291-7.
  • McAllan L, Skuse P, Cotter PD, O'Connor P, Cryan JF, Ross RP, Fitzgerald G,        Roche HM, Nilaweera, KN. Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and fatty acids and  polyphenols. Mol Nutr Food Res. 58(8):1708-1720, 2014.
  • McElnea E.M, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M,  Farrell M, Clark A.F, O'Brien C.J, Wallace D.M. Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells. BMC Ophthalmol. 14:153. 2014.
  • Miras AD, Al-Najim W, Jackson SN, McGirr J, Cotter L, Tharakan G, Vusirikala A, le Roux CW, Prechtl CG, Scholtz S. Psychological characteristics, eating behavior, and quality of life assessment of obese patients undergoing weight loss interventions. Scand J Surg. 2014 Jul 22.
  • Miras AD, Risstad H, Baqai N, Law S, Søvik TT, Mala T, Olbers T, Kristinsson JA, le Roux CW. Application of the International Diabetes Federation and American Diabetes Association criteria in the assessment of metabolic control after bariatric surgery. Diabetes Obes Metab. 2014 Jan;16(1):86-9.
  • Miras AD, Seyfried F, Phinikaridou A, Andia ME, Christakis I, Spector AC, Botnar RM, le Roux CW. Rats fed diets with different energy contribution from fat do not differ in adiposity. Obes Facts. 2014;7(5):302-10.
  • Neff KJ, Chuah LL, Aasheim ET, Jackson S, Dubb SS, Radhakrishnan ST, Sood AS, Olbers T, Godsland IF, Miras AD, le Roux CW. Beyond weight loss: evaluating the multiple benefits of bariatric surgery after Roux-en-Y gastric bypass and adjustable gastric band. Obes Surg. 2014 May;24(5):684-91.
  • Neff KJ, Prener C, Chuah LL, O'Donnell K, Godsland IF, Miras AD, le Roux CW. A holistic assessment of bariatric surgical outcomes in a Northern Irish cohort. Ir Med J. 2014 Jan;107(1):24-6.
  • O'Grada CM, Morine MJ, Morris C, Ryan M, Dillon ET, Walsh M, Gibney ER, Brennan L, Gibney MJ, Roche HM.  PBMCs reflect the immune component of the WAT transcriptome--implications as biomarkers of metabolic health in the postprandial state. Mol Nutr Food Res. 58(4):808-20, 2014.
  • Papamargaritis D, Aasheim ET, Sampson B, le Roux CW. Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation. J Trace Elem Med Biol. 2014 Sep 16. pii: S0946-672X(14)00174-6.
  • Rodríguez-Peña A.B, Fuentes-Calvo I, Docherty N.G, Arévalo M, Grande M.T, Eleno N, Pérez-Barriocanal F, López-Novoa J.M. Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy. Biomed Res Int. 2014:124902 2014.
  • Salinari S, le Roux CW, Bertuzzi A, Rubino F, Mingrone G. Duodenal-jejunal bypass and jejunectomy improve insulin sensitivity in Goto-Kakizaki diabetic rats without changes in incretins or insulin secretion. Diabetes. 2014 Mar;63(3):1069-78.
  • Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone AP. Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. Gut. 2014 Jun;63(6):891-902.
  • Seyfried F, Bueter M, Spliethoff K, Miras AD, Abegg K, Lutz TA, le Roux CW. Roux-en Y Gastric Bypass Is Superior to Duodeno-Jejunal Bypass in Improving Glycaemic Control in Zucker Diabetic Fatty Rats. Obes Surg. 2014 Jun 15.
  • Tako AA, Kotiadis K, Vasilakis C, Miras A, le Roux CW. Improving patient waiting times: a simulation study of an obesity care service. BMJ Qual Saf. 2014 May;23(5):373-81.
  • Taylor DR, Alaghband-Zadeh J, Cross GF, Omar S, le Roux CW, Vincent RP. Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2. PLoS One. 2014 Apr 15;9(4):e93540.
  • Tobin AM, Hackett CB, Rogers S, Collins P, Richards HL, O'Shea D, Kirby B. Body Mass Index, Waist Circumference and HOMA-IR correlate with PASI in psoriasis patients receiving phototherapy. Br J Dermatol. 2014 Feb 23.
  • Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. Diabetes. 63(6):2037-50, 2014.
  • Werling M, Fändriks L, Royce VP, Cross GF, le Roux CW, Olbers T. Preoperative assessment of gut hormones does not correlate to weight loss after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2014 Sep-Oct;10(5):822-8.
  • Yang S, Wang B, Humphries F, Hogan AE, O'Shea D, Moynagh PN. The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance. Immunity. 2014 Dec 18;41(6):973-87.

2013

  • Brennan EP, Nolan KA, Borgeson E,  Gough OS, McEvoy C, Docherty NG, Higgins DF, Murphy M, Sadlier DM,Ali-Shah T, Guiry PJ, The GENIE Consortium, Savage D, Maxwell AP, Martin F, Godson C* Lipoxins attenuate renal fibrosis by induction of let-7c and suppression of TGFβR1 J Am Soc Nephrol 2013, 24(4):627-37.
  • Briggs AD, Mytton OT, Madden D, O'Shea D, Rayner M, Scarborough P. The potential impact on obesity of a 10% tax on sugar-sweetened beverages in Ireland, an effect assessment modelling study. BMC Public Health. 2013 Sep 17;13:860.
  • Carolan E, Hogan AE, Corrigan M, Gaotswe G, O'Connell J, Foley N, O'Neill LA, Cody D, O'Shea D. The impact of childhood obesity on inflammation, innate immune cell frequency and metabolic microRNA expression. J Clin Endocrinol Metab. 2013 Jan 1.
  • Cohen R, le Roux CW, Papamargaritis D, Salles JE, Petry T, Correa JL, Pournaras DJ, Galvao Neto M, Martins B, Sakai P, Schiavon CA, Sorli C. Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes. Diabet Med. 2013 Jun 26. doi: 10.1111/dme.12268.
  • de Gaetano M, Dempsey E, Marcone S, James WG, Belton O. Conjugated linoleic acid targets β2 integrin expression to suppress monocyte adhesion. J Immunol. 2013 Oct 15;191(8):4326-36.
  • de Jonge C, Rensen SS, Verdam FJ, Vincent RP, Bloom SR, Buurman WA, le Roux CW, Schaper NC, Bouvy ND, Greve JW. Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes. Obes Surg. 2013 Sep;23(9):1354-60.
  • Faherty, N., O’Donovan, H.C., Kavanagh, D., Madden, S., McKay, G.J., Maxwell, A.P., Martin, F., Godson, C. and Crean, J. TGF-beta and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation. BMC Genomics 2013, 14:525  doi:10.1186/1471-2164-14-525.
  • Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, O'Connell J, O'Shea D. Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia. 2013 Dec 21.
  • Irnaten M, Barry R.C, Wallace D.M, Docherty N.G, Quill B, Clark A.F, O'Brien C.J. Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells. Exp Eye Res. 115C:224-229. 2013
  • Kavanagh, D., Savage, D.A., Patterson, C., McKnight, A.J., Crean, J., Alexander P Maxwell, A.P.,  McKay, G.J. Haplotype association analysis of genes within the WNT signalling pathways indiabetic nephropathy BMC Nephrology 2013, 14:126.
  • Lynch, J., Meehan, M.H., Crean, J., Copeland, J., Stallings, R.L., Bray, I.M. Metastasis Suppressor microRNA-335 Targets the Formin Family of Actin Nucleators. PLoS One. 2013 Nov 5;8(11).
  • McArdle MA, Finucane OM, Connaughton RM, McMorrow AM, Roche HM. Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front. Endocrinol 4, 52, 2013.
  • McCarthy C, Duffy MM, Mooney D, James WG, Griffin MD, Fitzgerald DJ, Belton O. IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis. FASEB J. 2013 Feb;27(2):499-510.
  •  McCarthy C, Lieggi NT, Barry D, Mooney D, de Gaetano M, James WG, McClelland S, Barry MC, Escoubet-Lozach L, Li AC, Glass CK, Fitzgerald DJ, Belton O Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid. EMBO Mol Med. 2013 Sep;5(9):1443-57.
  • O'Shea D, Corrigan M, Dunne MR, Jackson R, Woods C, Gaoatswe G, Moynagh PN, O'Connell J, Hogan AE. Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection Int J Obes (Lond). 2013 Feb.
  • Osto M, Abegg K, Bueter M, le Roux CW, Cani PD, Lutz TA. Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine. Physiol Behav. 2013 Jul 2;119:92-6.
  • Phillips CM, Tierney AC, Perez-Martinez P, Defoort C, Blaak EE, Gjelstad IMF, Lopez-Miranda J, Kiec-Klimczak M, Malczewska-Malec M, Drevon CA, Hall W, Lovegrove JA, Karlstrom B, Risérus U, Roche HM. Obesity and body fat classification in the metabolic syndrome: Impact on cardiometabolic risk metabotype.  Obesity 21 (1): E154-E161, 2013.
  • Pournaras DJ, le Roux CW. Are bile acids the new gut hormones? Lessons from weight loss surgery models. Endocrinology. 2013 Jul;154(7):2255-6.
  • Sam AH, Busbridge M, Amin A, Webber L, White D, Franks S, Martin NM, Sleeth M, Ismail NA, Daud NM, Papamargaritis D, le Roux CW, Chapman RS, Frost G, Bloom SR, Murphy KG. Hepcidin levels in diabetes mellitus and polycystic ovary syndrome. Diabet Med. 2013 Jun 24. doi: 10.1111/dme.12262.
  • Seyfried F, Miras AD, Bueter M, Prechtl CG, Spector AC, le Roux CW. Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats. Surg Endosc. 2013 Nov;27(11):4192-201.
  • Vincent RP, Omar S, Ghozlan S, Taylor DR, Cross G, Sherwood RA, Fandriks L, Olbers T, Werling M, Alaghband-Zadeh J, le Roux CW. Higher circulating bile acid concentrations in obese patients with type 2 diabetes. Ann Clin Biochem. 2013 Jul;50(Pt 4):360-4.
  • Wallace, D.M., Clark, A.F., Lipson K.E., Andrews, D., Crean, J., O'Brien, C.J. Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells. Invest Ophthalmol Vis Sci. 2013 Dec 2;54(13):7836-48.
  • Werling M, Olbers T, Fändriks L, Bueter M, Lönroth H, Stenlöf K, le Roux CW. Increased postprandial energy expenditure may explain superior long term weight loss after Roux-en-Y gastric bypass compared to vertical banded gastroplasty. PLoS One. 2013;8(4):e60280.
  • Werling M, Vincent RP, Cross GF, Marschall HU, Fändriks L, Lönroth H, Taylor DR, Alaghband-Zadeh J, Olbers T, le Roux CW. Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery. Scand J Gastroenterol. Nov;48(11):1257-64. doi: 10.3109/00365521.2013.833647. Epub 2013 Sep 18.
  • Yubero-Serrano EM, Delgado-Lista J, et al, Perez-Jimenez F, Roche HM, Lopez-Miranda J. Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study. Exp Mol Med 45(6): p.e28. 2013.

2012

  • Brennan E, Morine MJ, Walsh DW, Roxburgh,S Lindenmeyer M, Brazil DP Ó Gaora P, Roche H, Sadlier DM,  Cohen CD, The GENIE Consortium; GodsonC*, MartinF Next-Generation Sequencing Identifies TGF-1-Associated Gene Expression Profiles in Renal Epithelial Cells Reiterated in Human Diabetic Nephropathy BBA Biochim Biophys Acta. 2012;1822(4):589-599.
  • Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA. Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production. Immunity. 2012 Sep 21;37(3):574-87. PMID: 22981538.
  • Oliver E, McGillicuddy FC, Harford KA, Reynolds CM, Phillips CM, Ferguson JF, Roche HM. Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. J Nutr Biochem 23(9): 1192-1200, 2012.

2011

  • Abbasakoor NO, Healy ML, O'Shea D, Maguire D, Muldoon C, Sheahan K, O'Toole D. Metastatic insulinoma in a patient with type 2 diabetes mellitus: case report and review of the literature.  Int J Endocrinol. 2011;2011:124078.
  • Brogan A, Hevey D, O'Callaghan G, Yoder R, O'Shea D. Impaired decision making among morbidly obese adults J Psychosom Res. 2011 Feb;70(2):189-96.
  • Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clin Immunol. 2011 Feb 2.
  • Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D. Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia. 2011 Jul 9.
  • Macananey O, Reilly H, O'Shea D, Egaña M, Green S. Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise. Diab Vasc Dis Res. 2011 Jan;8(1):12-21.
  • Mazzei L.J, García I.M, Altamirano L, Docherty N.G, Manucha W. Rosuvastatin Preserves Renal Structure following Unilateral Ureteric Obstruction in the Neonatal Rat. Am J Nephrol. 2011 .5(2):103-113.

 

View my collection, "Diabetes Complications Research Centre" from NCBI