Meet the Team

Academic Investigators

Prof Catherine Godson
Professor of Molecular Medicine/Centre Director

Dr John Crean
Lecturer in Pharmacology/Associate Professor

Prof Carel Le Roux
Professor of Experimental Pathology

Prof Finian Martin
Emeritus Associate Professor of Pharmacology

Dr Daniel Crean
Lecturer/Assistant Professor

Dr Neil Gerard Docherty
Lecturer in Anatomy/Assistant Professor

Dr Orina Belton
Associate Professor

Dr Fiona McGillicuddy
Assistant Professor

Prof Helen Roche
Professor of Nutrigenomics

 

Professor Orina Belton

Orina Belton

  Professor, UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  School of Biomolecular and Biomedical Sciences
  University College Dublin, Belfield, Dublin 4.
  Tel: +353 1 716 6748
  Email: orina.belton@ucd.ie

My research is directed towards understanding the mechanisms governing the resolution of atherosclerosis through identification of novel pathways that alter monocyte/macrophage function and phenotype in vivo and in patients with the disease. My laboratory established a novel model of atherosclerosis regression in vivo, achieved by administration of conjugated linoleic acid (CLA) apoE knockout mouse model. Using Intravital Microscopy they have shown CLA inhibits monocyte recruitment, monocyte-endothelial cell adhesion and trans-endothelial migration in the carotid and femoral arteries; providing novel in vivo insights into the molecular mechanisms mediated by CLA.

Professor Donal Brennan

Prof Donal Brennan - 200 x 300

  Professor of Gynaecological Oncology
  UCD Diabetes Research Centre
  UCD School of Medicine
  UCD Catherine McAuley Research & Education Centre
  Mater Misericordiae University Hospital
  Email: donal.brennan@ucd.ie

I am a Clinician Scientist and graduated from University College Dublin School of Medicine in 2003. I was awarded a PhD in cancer biology by University College Dublin in 2008 and undertook specialist training in Obstetrics and Gynaecology working in the National Maternity Hospital, Cork University Maternity Hospital, The Coombe and The Rotunda Maternity hospitals. During my specialist training, I also retained a post-doctoral position at the UCD Conway Institute of Biomolecular and Biomedical Science. I am currently UCD Professor of Gynaecological Oncology and Consultant Obstetrician and Gynaecological Oncologist at the Mater Misericordiae University Hospital, the National Maternity Hospital and St Vincent's University Hospital

My main research interests are in biomarker development, tumour inflammation and obesity related carcinogenesis. I have an active research group in collaboration with Prof Carel Le Roux examining the underlying molecular mechanisms of obesity induced carcinogenesis. We are using cell line and animal models to investigate this. We are also developing clinical studies to investigate the effect of intentional weight loss on endometrial cancer biology. I am also a senior investigator on the first randomised study of weight loss as a treatment of endometrial cancer - the FeMMe trial is recruiting patients in Australia at present. I also research in Precision Medicine Solutions for Ovarian Cancer. We are currently developing novel predictive assays to improve patient stratification in ovarian cancer. In collaboration with Prof Gil Lee, Prof Walter Kolch and collaborators in RCSI and Queens we are developing novel, high throughput, multicellular 3D cell culture models.

Dr Daniel Crean

Dr Daniel Crean

  Assistant Professor / Lecturer, UCD School of Veterinary Medicine
  Veterinary Science Centre, Belfield, Dublin 4
  Tel: +353 1 716 6238
  Email: Daniel.Crean@ucd.ie

My key areas of research interest are inflammation and metabolism. Currently my group is investigating the signalling events in cells that control inflammatory responses. I am also a collaborator on the Science Foundation Ireland (SFI) funded Centre for Research in Medical Devices (CURAM) where my group has a keen interest in the development of novel approaches to the delivery of anti-inflammatory drugs. My group are also investigating the re-purposing of existing therapeutics for the treatment of organ damage in diabetes.

Associate Professor John Crean

John Crean

  Associate Professor in Pharmacology
  UCD Diabetes Complications Research Centre
  Conway Institute of Biomolecular and Biomedical Research
  UCD School of Biomolecular and Biomedical Sciences
  University College Dublin, Belfield, Dublin 4.
  Tel: +353 1 716 6747
  Email: john.crean@ucd.ie

Associate Professor Crean has been engaged in research in the general area of cell-matrix interactions since completing his PhD in 1998. In 2007 he was appointed to the Faculty of Science in University College Dublin as a tenure-track Lecturer in Pharmacology, was awarded tenure in 2009, promoted to Senior Lecturer in 2013 and appointed Associate Professor and Head of Pharmacology in 2015. During this time he has been in receipt of >€3,000,000 in funding from the Irish Health Research Board, Irish Research Council and Science Foundation Ireland among others and has established himself as a world-leading expert on CCN proteins and their role in renal injury and renal cell plasticity and published extensively in leading journals (>2250 citations, H index 2017 = 25). Professor Crean has supervised 10 PhD students to completion and is currently principal supervisor for 4 further PhD candidates and 2 M.Sc. students, comprising a research team embedded within the UCD Diabetes Complications Research Centre. His programme is supported by collaborations in critical areas such as epigenetics (Eileen Furlong, EMBL Heidelberg) mass spectrometry (Gerard Cagney, UCD), stem cell biology (Fiorella Altruda, Turin) and renal function (Derek Brazil, QUB; Roel Goldschmeding, Utrecht). The supervisors research team and collaborators have a wealth of experience in molecular and cellular biology, genomics, proteomics and models of disease.

The recognition that dedifferentiated surviving proximal tubule cells are the key to repair of kidney injury laid the foundation for groundbreaking studies that first defined the methods for the specification of renal epithelial cells from stem cells. The subsequent explosion of interest in the use of developmental cues to coax pluripotent cells into forming kidney like structures led directly to the formation of organoids and mini-kidneys by Melissa Little and the emerging regenerative potential of “kidney in a dish”. Recent studies from the Crean laboratory and others have established that an ESC-enriched noncoding RNA, miR-302, can induce somatic cell reprogramming to form iPSCs via an epigenetic mechanism similar to the natural zygotic reprogramming process in the two- to eight-cell-stage embryos. The establishment of a transcriptionally permissive state (essentially globally demethylated) subsequently triggers the activation of the Yamanaka factors Oct4, Sox2, and Nanog to complete the reprogramming process. Our data strongly suggests that silencing of the TGF beta type II receptor results in the ablation of Smad3 signalling, which prevents the targeting of the PRC2 complex to specific loci facilitating their de-repression (Oliviero et al., 2016). We have successfully exploited this switch for the generation of renal epithelial-like cells from primary fibroblast cells (DeChiara et al., 2017) and identified Wnt6 as a new and novel driver of renal epithelial specification (Beaton et al., 2016).

Dr Neil Gerard Docherty

Neil Gerard Docherty

  Assistant Professor/Lecturer, UCD School of Medicine
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  University College Dublin, Belfield, Dublin 4.
  Tel: +353 1 716 6877
  Email: neil.docherty@ucd.ie

I am Faculty member in the Discipline of Anatomy at The UCD School of Medicine and Co-Director of the Metabolic Medicine research group at the DCRC. I am also a Guest Researcher at The Department of Gastrosurgical Research & Education at University of Gothenburg, Sweden. I am co-author on 80 full length manuscripts in international peer reviewed journals and 4 book chapters (current H-index of 24). 

My research efforts are focused on understanding the mechanisms of action of bariatric/metabolic surgery with a special emphasis on attendant impact on renal microvascular complications of diabetes. Major current funding sources are project grants from the Irish Health Research Board and The European Foundation for the Study of Diabetes.

Professor Catherine Godson, Centre Director

Prof Catherine Godson - 464 x 613

  Professor Catherine Godson
  Professor of Molecular Medicine/Centre Director
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  UCD School of Medicine
  University College Dublin, Belfield, Dublin 4.
  Tel: +353 1 716 6731
  Email: Catherine.godson@ucd.ie

‌Professor Catherine Godson obtained her BSc (Biochemistry) and PhD (Pharmacology) from UCD and, following postdoctoral fellowships at the University of Geneva and at University of California San Diego, joined the faculty of Harvard University in 1994. She returned to UCD in 1997 where she was appointed Professor of Molecular Medicine. She served as the University’s Vice President, Innovation and Corporate Partnerships (2004–2007). In 2007, she was appointed Director of UCD Diabetes Complications Research Centre, where she leads a major research programme funded by Science Foundation Ireland, The Health Research Board, EU, Wellcome Trust, JDRF  and collaborators in biopharmaceutical industry. Her research focuses on innate immunity and chronic complications of diabetes.

Her team’s investigations on the molecular mechanisms underlying the initiation, progression and potential regression of diabetic complications have identified several novel therapeutic targets, disease susceptibility genes and potential modulators of disease. She has served at board level on the Health Research Board in (2007-2012), the European Medical Research Council of the European Science Foundation (2008-2012), and on several international grant review committees, including the Wellcome Trust Physiological Sciences Committee (2007-2010). In 2011, she was elected to membership of The Royal Irish Academy. She Chaired the academy’s Life Sciences and Medicine committee (2014-2018). She was appointed adviser to the board of Bart’s Trust (2018) and she has served on the editorial boards of several journals including J. Biol. Chem, Mol. Pharm and Am J Physiol.  

 

Ms Helen Heneghan (MB BCh BAO, PhD, FRCS)

Helen Heneghan

  Consultant Bariatric Surgeon
  St Vincent's University Hospital
  Elm Park, Dublin 4.

I am a graduate of NUI Galway and completed basic surgical training in Galway University Hospital. I have a PhD in the molecular expression of breast cancer and obesity from NUI Galway and completed the RCSI Higher Surgical Training scheme in General Surgery in 2016.  My research interests include evaluating the mechanisms of diabetes remission after bariatric surgery and evaluating the effect of significant weight loss on cancer, specifically female cancers such as breast and uterine cancer. I am also interested in studying the effect of bariatric surgery on fatty liver disease, specifically NASH (non-alcoholic steatohepatitis).

Professor Carel Le Roux

Prof Carel Le Roux

  Full UCD Professor of Exerimental Pathology
  UCD Diabetes Complications Research Centre
  UCD School of Medicine
  UCD Conway Institute of Biomolecular and Biomedical Research
  University College Dublin, Belfield, Dublin 4.
  Tel: +353 1 716 6831
  Email: carel.leroux@ucd.ie

I am Faculty member in the Section of Surgery and Surgery-related specialties at The UCD School of Medicine and Co-Director of the Metabolic Medicine research group at the DCRC. I am also a Guest Professor at The Department of Gastrosurgical Research & Education at University of Gothenburg, Sweden. I am co-author on more than 240 full length manuscripts in international peer reviewed journals and 4 book chapters (current H-index of 45).

My research efforts are focused on understanding how the gut talks to the brain and how this can be utilised to improve metabolic health. Major current funding sources are project grants from Science Foundation Ireland, Swedish Medical Research Council, the Irish Health Research Board and The European Foundation for the Study of Diabetes. 

Dr Fiona McGillicuddy

Dr Fiona McGillicuddy

  Assistant Professor, UCD School of Medicine
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Science
  University College Dublin, Belfield, Dublin 4.
 

Tel: +353 1 716 6769

 

Email: fiona.mcgillicuddy@ucd.ie

I am a Wellcome Trust Research Career Development Fellow and member of academic staff in the subject of Pathology, within the UCD School of Medicine, and lead the Cardiometabolic Research Group within the DCRC. I am very interested in the impact of obesity and diabetes on lipid metabolism pathways with a focus on the effects of metabolic disease on high-density lipoprotein (HDL) particle biology. I am also interested in initiatives to increase patient participation within diabetes research and am co-organiser of ‘The Patient Voice in Diabetes’ events. I am an early stage career investigator with current H-index of 17 and 1879 citations to date. I am currently funded by The Wellcome Trust (principal investigator), The European Foundation for the Study of Diabetes Grant, The Meath Foundation and the Irish Endocrine Society (co-investigator).

Professor Donal O'Shea

Prof Donal O'Shea

  UCD Full Clinical Professor, UCD School of Medicine
  Department of Endocrinology & Diabetes Mellitus
  St Vincent's University Hospital
  Elm Park, Dublin 4.
  Tel: +353 1 209 4407
  Email: info@dosheando.ie

My work focusses on diabetes, obesity, steroid metabolism and thyroid disorders.  I am a consultant endocrinologist and physician based in St. Vincent’s University Hospital and St. Columcille’s Hospital.  Since 1999, I have been the lead clinician for a hospital-based multi-disciplinary obesity service that includes bariatric surgery.  In recent years I chaired the health impact assessment group on the potential benefits and harms of a tax on sugar-sweetened drinks and co-chairs the Royal College of Physicians Policy Group on Obesity.

Professor Helen Roche

Prof Helen Roche

  Professor of Nutrigenomics
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  School of Public Health, Physiotherapy and Sports Science
  University College Dublin, Belfield, Dublin 4.
  Tel: +353 1 716 6845
  Email: helen.roche@ucd.ie

 

I am Professor of Nutrigenomics and a SFI Principal Investigator. Prior to that I was a Wellcome Trust Fellow & Senior Lecturer in Molecular Nutrition at TCD. The current focus of my  work includes:

  • Investigations of genetic determinants of nutrient status, metabolic response and predisposition to diet-related diseases (insulin resistance, type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), some chronic pro-inflammatory conditions and cancers) 
  • Additionally, my team investigates nutrient regulation of gene / protein expression, genetic determinant of responsiveness to nutritional therapy and/or diet-related disease progression, and the effects of dietary fatty acids on the expression of the genes involved in metabolic health (T2DM, CVD, inflammation and colon cancer).

Clinical Investigators

Prof Yvonne O’Meara
Professor/Consultant Nephrologist

Prof Denise Sadlier
UCD Clinical Professor/Consultant Nephrologist

Prof Donal Brennan
Professor of Gynaecological Oncology

Prof Donal O'Shea
UCD Full Clinical Professor

Assoc Prof John Holian
UCD Associate Clinical Professor

Assoc Prof Silke Ryan
UCD Associate Clinical Professor

Ms Helen Heneghan
Consultant Bariatric Surgeon

 

Research Support Staff, Fellows & Students

Research Fellows

  • Dr Eoin Brennan
  • Dr Maria Hughes

Research Project Manager

  • Dr Tracey McCauley

Current Postdoctoral Researchers

  • Dr Werd Al-Najim
  • Dr Monica de Gaetano

 

  • Dr Darrell Andrews
  • Dr Caoileann Murphy

Current PhD Students

  • Dr Ross Doyle
  • Antonino Cacace
  • Meera Nair
  • Priyah Sinclair
  • Robyn Bruen
  • Stephen Fitzsimons
  • Kawthar Alghamdi
  • Sean Curley
  • Elaine Kennedy
  • Karl Cogan
  • Patrick Swan

 

  • Gina Lynch
  • Marcella O'Reilly
  • Jessica Davis
  • Thomas Dodd
  • Ciaran Kennedy
  • Dr Conor Murphy
  • Sarina Kajani
  • Natasha Kapoor
  • Dr Eileen Nolan
  • Yvonne Lenighan 

MSc Students

  • Aisling Mangan
  • James White
 

Research Assistant:

  • Mariam Marai

Senior Technician/Laboratory Manager

  • Mr Andrew Gaffney

Dr Tracey McCauley, Research Project Manager

Tracey McCauley

  Research Project Manager
  UCD Diabetes Complications Research Centre
  Conway Institute of Biomolecular and Biomedical Research
  UCD School of Medicine
  University College Dublin, Belfield, Dublin 4
  Tel: +353 1 716 6844
  Email: tracey.mccauley@ucd.ie

I currently work as a research project manager in the UCD Diabetes Complications Research Centre. My main duties are to provide support to ongoing research activities and strategic planning initiatives at the centre enabling DCRC strategy development in line with the institutional Personalised and Translational Medicine theme. I also provide management support to The Wellcome Institutional Strategic Support Fund (ISSF) which is supported under the SFI-HRB-Wellcome Biomedical Research Partnership, with matched funding from UCD. It aims to help UCD’s researchers overcome systemic barriers to career and network development, ultimately unlocking future research potential within the University and beyond.  Within this I also provide support to recipients of the ISSF Mid-Career Stimulus and Diversification and Clinical Primer Schemes. The purpose of the Mid-Career Stimulus and Diversification Scheme is to support excellent mid-career researchers. The Clinical Primer Scheme will allow early stage candidates an opportunity to work in a research environment, generating significant research outcomes that can be leveraged to pursue extramural funding.

Prior to this I worked, initially as a Postdoctoral Researcher, which evolved to project management and coordination of a European Commission FP7-funded Clinical Officer Surgical Training in Africa (COST-Africa) project at the Royal College of Surgeons in Ireland. Before pursuing this role, I worked as a post doc researcher at the University of Nottingham on a Physical Activity Intervention in GP primary care. I graduated from Loughborough University in 2009 with a PhD in Exercise Physiology and in 2005 with a MSc in Physical Activity and Health. 

Dr Eoin Brennan, Research Fellow

Dr Eoin Brennan

  Research Fellow (PI: Professor Catherine Godson)
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  UCD School of Medicine
  University College Dublin, Belfield, Dublin 4.
 

Email: eoin.brennan@ucd.ie        

My research to date has focused on microvascular complications of diabetes, including kidney damage, as well as associated atherosclerosis and cardiovascular diseases. During my career I have had the opportunity to carry out my research in world-class facilities in Ireland, UK, USA and Australia. My investigations have utilised human tissues, animal models of disease, and cell model systems leading to the identification of novel modulators of disease and potential markers of susceptibility and progression of diabetic complications, obesity and vascular diseases. Projects I am currently involved in include: exploring the role of micro-RNA and pro-resolving lipids as pro-resolution therapeutics in disease; in vivo models of diabetic complications; global transcriptomic profiling of human renal and vascular tissues; and participation in an international large-scale genomics studies investigating mutations associated with diabetic kidney disease. My work is funded by Science Foundation Ireland and the US Juvenile Diabetes Research Foundation.

Dr Maria Hughes, Research Fellow

Dr Maria Hughes

  Research Fellow (PI: Prof Catherine Godson & Prof Helen Roche)
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  UCD School of Medicine
  UCD Schoo of Public Health, Physiotherapy and Sports Science
  University College Dublin, Belfield, Dublin 4.
  Email: Maira.hughes@ucd.ie

I have a BSc in Molecular Biology and PhD in Population Genetics from Queens University Belfast. My previous research has focused on cardiovascular disease epidemiology including OMICs and biomarker evaluation for understanding mechanisms and prediction of disease risk. Taking a bioinformatics perspective, I am developing an integrated risk profile for chronic & diabetic kidney disease incorporating genomic, transcriptomic, epigenetic and biomarker data in a project funded through SFI-DEL. My role in nutrigenomics research is to evaluate transcriptomic and metabolomic signatures in response to nutritional intervention clinical trials to better understand immunometabolic and cardiovascular disease risk which is funded through the FOODBALL project. 

Dr Werd Al-Najim, Post-Doctoral Researcher

Dr Werd Al-Najim

  Post-Doctoral Researcher (PI: Professor Carel Le Roux)
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  UCD School of Medicine
  Universiity College Dublin, Belfield, Dublin 4.
 

Email: werd.al-najim@ucd.ie

I am a Postdoctoral Researcher investigating direct measure of behaviour in patients with obesity and obesity related comorbidities to optimise weight loss treatments. I hold a Bachelor Degree in Nutrition Science from Kingston University in London. I completed a PhD at Imperial College London where I investigated a novel endoscopic intervention for obesity (the EndoBarrier) on food preferences in people with obesity and Type 2 Diabetes. I also hold a health coaching certificate from the Integrative Nutrition school in New York.

Over the past 6 years, I was involved in ground breaking research in the areas of obesity and diabetes in both London and Dublin. I co-ordinated a number of commercial and academic studies and now work in the Metabolic Medicine Lab in University College Dublin and Medfit Proactive Healthcare on an Enterprise Partnership Scheme grant funded by the Irish Research council. 

Dr Darrell Andrews, Post-Doctoral Researcher

Darrell Andrews Post-Doctoral Researcher at the UCD Diabetes Complications Research Centre

   Post-Doctoral Researcher (PI: Prof Catherine Godson) 
   UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Science
  UCD School of Medicine
  University College Dublin, Belfield, Dublin 4
  Email:darrell.andrews@ucd.ie  

I received a B.Sc (Hons) in Biological Science with Chemistry from the University of Limerick in 2010 and a M.Sc in Biotechnology from University College Dublin in 2011. In 2012 I was awarded an Irish Research Council postgraduate scholarship to pursue a PhD under the supervision of Assoc Prof John Crean at the UCD Conway Institute. My PhD studies focused on understanding the molecular mechanisms underlying the microvascular complications of diabetes particularly diabetic eye disease. I investigated how crosstalk between canonical signalling pathways and epigenetic machinery contributes to the pathogenesis of diabetic eye disease.

In 2016 I joined Prof Godson’s lab as a post doctoral research fellow to continue my work on the microvascular complications of diabetes. My current research project focuses on elucidating the functionality of genetic and epigenetic targets identified by our colleagues in the GENIE (GEnetics of Nephropathy an International Effort) consortium on the pathogenesis of diabetic kidney disease. I am using a reverse genetics approach to interrogate these targets in both cell culture models and zebrafish models of renal disease. I am particularly interested in exploring the utility of the zebrafish larvae as an investigative tool to model renal development and disease. 

Dr Monica De Gaetano, Post-Doctoral Researcher

Dr Monica De Gaetano

  Post-Doctoral Researcher (PI: Professor Catherine Godson)
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  UCD School of Medicine
  University College Dublin, Belfield, Dublin 4.
  Email: monica.degaetano@ucd.ie

I am currently a 2-year-awarded Senior Postdoctoral Fellow, funded by the Irish Research Council, under the mentorship of Prof Catherine Godson, as part of the Diabetes Complications Research Centre in UCD, Dublin, Ireland.

Graduated in the School of Pharmacy from “La Sapienza” University in Rome (Italy), I firstly worked as a Research Fellow in the Catholic University of the Sacred Heart in Campobasso (Italy) on the genetics and the epidemiology of Cardiovascular Diseases, and then I moved to Ireland in 2009 to pursue my PhD in Immunology, in the Ass Prof Orina Belton’s lab in UCD.

My research experience, in higher education academies and also in a clinical trial company, expands from Epidemiology, Molecular Biology and Cell Signalling in the context of Cardiovascular diseases, with a particular interest in Atherosclerosis. The models used in my studies include human tissues, cell lines and peripheral blood cells, particularly monocytes and macrophages.

My current basic science focuses on investigating the pathogenetic mechanisms of prevalent chronic inflammatory diseases, such as atherosclerosis and diabetes-associated cardiovascular diseases.

The inflammatory component of such complexes and multifactorial disease is the key-aspect of my research, which aims to elucidate how to prevent and/or regress pre-established atherosclerosis. 

More recently, I am coordinating a Science Foundation Ireland-funded screening programme in collaboration with Prof Pat Guiry and the Center for Synthesis and Chemical Biology in UCD, which successfully highlighted the potential of newly synthesised molecules with both anti-inflammatory and pro-resolving properties. These bio active compounds could represent new therapeutic targets in the Resolution Pharmacology.

Dr Caoileann Murphy, Post-Doctoral Researcher

Dr Caoileann Murphy

  Post-Doctoral Researcher (PI: Professor Helen Roche)
  UCD Diabetes Complications Research Centre
  UCD Conway Institute of Biomolecular and Biomedical Research
  UCD School of Public Health, Physiotherapy and Sports Science
  University College Dublin, Belfield, Dublin 4.
 

Email: caoileann.murphy@ucd.ie

My research is focused on the impact of nutrition, both alone and in combination with exercise, on muscle protein turnover and physiology in humans.  My research centers around nutritional strategies to attenuate to the insidious and detrimental loss of muscle mass and function with age (termed sarcopenia). In addition, my work attempts to address how nutrition and exercise can support “high quality weight loss” (i.e. the loss of body weight with the greatest ratio of fat to muscle mass). This has become an increasingly important issue due to the rise in obesity prevalence among older adults. More recently, my work in ageing has adopted a more personalised perspective and aims to provide insight into why some older adults respond to nutrition interventions while others do not, and to identifying clinical biomarkers to predict who will benefit from nutrition interventions for sarcopenia. My research is funded by the TopMed10 Marie SkÅ‚odowska-Curie Fellowship, the ESPEN Fellowship and the Department of Agriculture Food and the Marine.