- Crean JK, Furlong F, Mitchell D, McArdle E, Godson C, Martin F. Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1). FASEB J. 2006;20(10):1712-4.
- Murphy M, Godson C, Cannon S, Kato S, Mackenzie HS, Martin F, Brady HR. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem. 1999;274(9):5830-4.
- McMahon R, Murphy M, Clarkson M, Taal M, Mackenzie HS, Godson C, Martin F, Brady HR. IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1. J Biol Chem. 2000;275(14):9901-4.
- Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR. The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem. 2002;277(46):44187-94.
- Dolan V, Murphy M, Sadlier D, Lappin D, Doran P, Godson C, Martin F, O'Meara Y, Schmid H, Henger A, Kretzler M, Droguett A, Mezzano S, Brady HR. Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy. Am J Kidney Dis. 2005;45(6):1034-9.
- Crean JK, Furlong F, Finlay D, Mitchell D, Murphy M, Conway B, Brady HR, Godson C, Martin F. Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization. FASEB J. 2004;18(13):1541-3.
- Clarkson MR, Murphy M, Gupta S, Lambe T, Mackenzie HS, Godson C, Martin F, Brady HR. High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. J Biol Chem. 2002;277(12):9707-12.
- Conway BR, Maxwell AP, Savage DA, Patterson CC, Doran PP, Murphy M, Brady HR, Fogarty DG. Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes. Diabetes. 2004;53(4):1162-5.
- Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, Brady HR. DNA oligonucleotide microarray technology identifies fisp-12 among other potential FibroGenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Kidney Int. 2003;64(6):2079-91.
- Sadlier DM, Connolly SB, Kieran NE, Roxburgh S, Brazil DP, Kairaitis L, Wang Y, Harris DC, Doran P, Brady HR. Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. J Biol Chem. 2004;279(28):29670-80.
- McMahon B, Mitchell D, Shattock R, Martin F, Brady HR, Godson C. Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. FASEB J. 2002 16(13):1817-9
- Mitchell D, Rodgers K, Hanly J, McMahon B, Brady HR, Martin F, Godson C. Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells. Am J Pathol. 2004;164(3):937-46.
- McMahon B, Godson C. Lipoxins: endogenous regulators of inflammation. Am J Physiol Renal Physiol. 2004;286(2):F189-201.
- Rodgers K, McMahon B, Mitchell D, Sadlier D, Godson C. Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells. Am J Pathol. 2005;167(3):683-94.
- McKnight AJ, Savage DA, Patterson CC, Brady HR, Maxwell AP. Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nerhropathy. J Hum Genet. 2006;51(4):383-6.
- McKnight AJ, Mazwell AP, Sawcer S, Compston A, Setakis E, Patterson CC, Brady HR, Savage DA. A genome-wide DNA microsatellite association screen to identify chromosomal regions harbouring candidate genes in diabetic nephropathy. J Am Soc Nephrol. 2006;17(3):831-6.
- Kane R, Stevenson L, Godson C, Stitt AW, O’Brien C Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose. Br J Ophthalmol. 2005;89(12):1638-42.
- Dolan V, Alarcon P, Martin F, Brady H , Hensey C. The role of the BMP antagonist gremlin in Xenopus pronephric development. J Am Soc Nephrol 2003 ;14: 17A-18A.
- Leonard MO, Hannan K, Burne MJ, Lappin DW, Doran P, Coleman P, Stenson C, Taylor CT, Daniels F, Godson C, Petasis NA, Rabb H, Brady HR. 15-Epi-16-(parafluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic actue renal failure. J Am Soc Nephrol. 2002;13(6):1657-62.
- Crean JK, Furlong F, Mitchell D, McArdle E, Godson C, Martin F. Connective tissue growth factor/CCN2 stimulates actin disassembly though Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27Kip-1. FASEB J. 2006;
- Soedamah-Muthu SS, Fuller JH, Mulnier HE, Raleigh VS, Lawrenson RA, Colhoun HM. High risk of cardiovascular disease in patients with type 1 diabetes in the U.K.: a cohort study using the general practice research database. Diabetes Care. 2006;29(4):798-804.
- Mulnier HE, Seaman HE, Raleigh VS, Soedamah-Muthu SS, Colhoun HM, Lawrenson RA. Mortality in people with type 2 diabetes in the UK. Diabet Med. 2006;23(5):516-21.
- Colhoun H. Coronary heart disease in women: why the disproportionate risk? Curr Diab Rep. 2006;6(1):22-8.
- Palmen J, Colhoun HM, Van Tol A, Hattori H, Humphries SE. A novel common variant -181 G insertion in the promoter of the gene for phospholipid transfer protein. Atherosclerosis. 2005;180(1):211-3.
- Colhoun HM, Scheek LM, Rubens MB, Van Gent T, Underwood SR, Fuller JH, Van Tol A. Lipid transfer protein activities in type 1 diabetic patients without renal failure and nondiabetic control subjects and their association with coronary artery calcification. Diabetes. 2001;50(3):652-9.
- Colhoun H. After FIELD: should fibrates be used to prevent cardiovascular disease in diabetes? Lancet. 2005;366(9500):1829-31.
- Colhoun HM, Betteridge DJ. Treatment of lipid disorders in patients with diabetes. Curr Treat Options Cardiovasc Med. 2006;8(1):37-45.
- Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Fuller JH; CARDS Investigators. Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the Collaborative Atorvastatin Diabetes Study (CARDS). Diabetologia. 2005;48(12):2482-5.
- Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, Fuller JH; CARDS investigators. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435):685-96.
- H. M. Colhoun on behalf of the EURODIAB Family Study Investigators; Candidate gene variant associations with diabetic microvascular disease in the EURODIAB Family Study. OP 36. Diabetologia 2005; 48 (S1).36.
- Tillin T, Forouhi N, Johnston DG, McKeigue PM, Chaturvedi N, Godsland IF. Metabolic syndrome and coronary heart disease in South Asians,African-Caribbeans and white Europeans: a UK population-based cross-sectional study. Diabetologia. 2005
- McKeigue PM. Prospects for admixture mapping of complex traits. Am J Hum Genet. 2005;76(1):1-7.
- Parra EJ, Hoggart CJ, Bonilla C, Dios S, Norris JM, Marshall JA, Hamman RF, Ferrell RE, McKeigue PM, Shriver MD. Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado. J Med Genet. 2004;41(11):e116.
- Blake C, O’Meara YM. Subjective and objective physical limitations in high-functioning renal dialysis patients. Nephrology Dialysis Transplantation 2004; 19:3124-3129
- Blake C, Cassidy A, Codd MB, O'Meara YM. Physical Function, Employment and Quality of Life in End-Stage Renal Disease. Journal of Nephrology 2000; 13(2): 142-149
- Blake C, Cassidy A, Codd M, Donohoe J, Walker F, Watson A, Keogh JAB, Brady HR, O'Meara YM. Impact of End-Stage Renal Disease (ESRD) on Employment and Personal Economics: Identification of Musculoskeletal Dysfunction as a Risk Factor for Unemployment. Kidney International. 1999; 55(6): 2576-2577
- MC Walsh, L Brennan, JP Malthouse, HM Roche, and MJ Gibney (2006) Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. Am J Clin Nutr ; 84: 531
- McCarthy SN, Robson PJ, Livingstone MB, Kiely M, Flynn A, Cran GW, Gibney MJ. Associations between daily food intake and excess adiposity in Irish adults: towards the development of food-based dietary guidelines for reducing the prevalence of overweight and obesity. Int J Obes (Lond). 2006;30(6):993-1002.
- Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B. Metabolomics in human nutrition: opportunities and challenges. Am J Clin Nutr. 2005;82(3):497-503.
- Roche HM, Phillips C, Gibney MJ. The metabolic syndrome: the crossroads of diet and genetics. Proc Nutr Soc. 2005;64(3):371-7.
- O'Dwyer NA, McCarthy SN, Burke SJ, Gibney MJ. The temporal pattern of the contribution of fat to energy and of food groups to fat at various eating locations: implications for developing food-based dietary guidelines. Public Health Nutr. 2005;8(3):249-57.
- Verlengia R, Gorjao R, Kanunfre CC, Bordin S, de Lima TM, Newsholme P, Curi R: Genes regulated by arachidonic and oleic acids in Raji cells. Lipids 2003;38: 1157-65.
- Verlengia R, Gorjao R, Kanunfre CC, Bordin S, de Lima TM, Martins EF, Newsholme P, Curi R: Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. Lipids 2004;39:857-64
- O'Dowd YM, El Benna J, Perianin A, Newsholme P: Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A(2) activity but not p47phox phosphorylation and translocation. Biochemical Pharmacology 2004; 67: 183-90
- Martins EF, Miyasaka CK, Newsholme P, Curi R, Carpinelli AR: Changes of fatty acid composition in incubated rat pancreatic islets - Evidence for fatty acid release. Diabetes & Metabolism 2004;30: 21-7
- Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P. Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity. Clinical Science 2004;106:191-9.
- Dixon G, Nolan J, McClenaghan N, Flatt PR, Newsholme P A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine. Journal of Endocrinology 2003;179:447-54.
- Brennan L, Corless M, Hewage C, Malthouse.jpg, McClenaghan NH, Flatt PR, Newsholme P. C-13 NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line. Diabetologia 2003;46: 1512-21.
- Verlengia R, Gorjão R, Kanunfre C, Bordin S, de Lima T, Martins EF, Newsholme P, Curi R. Effects of EPA and DHA on Proliferation, Cytokine Production and Genes Expression in Raji Cells. Lipids 2005;39: 857-864.
- Curi R, Lagranha CJ, Doi SQ, Sellitti F, Procopio J, Pithon-Curi TC, Corless M, Newsholme P. Molecular Mechanisms of Glutamine Action J. Cell. Physiol. (2005, In Press)
- Newsholme P, Brennan L, Rubi B, Maechler P. New insights into amino acid metabolism, beta cell function and diabetes. Clin Sci 2005;108, 185-194
- Martins EF, Miyasaka CK, Newsholme P, Curi R, Carpinelli AR. Changes of Fatty acid composition in incubated rat pancreatic islets. Diabetes and Metabolism. 2004;30: 21-27.
- Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P. Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta cell insulin secretion, growth and functional integrity. Clin Sci 2004;106, 191-199
- O’ Dowd YM, El-Benna J, Perianin A, Newsholme P. Inhibition of fMLP-stimulated respiratory burst in human neutrophils by adrenaline: Inhibition of Phospholipase A2 activity but not P47phox phosphorylation and translocation. Biochem Pharmacol. 2004;67, 183-190.
- Broca C, Brennan L, Petit P, Newsholme P, Maechler P. Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion. FEBS Lett. 2003;545:167-72.
- Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P. A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 – the functional significance of L-alanine. J. Endocrinol. 2003;179, 447-454.
- Brennan L, Corless M, Hewage C, Malthouse JPG, McClenaghan NH, Flatt PR, Newsholme P. 13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line. Diabetologia 2003;46: 1512 – 1521.
- Healy, D.A., Watson R.W.G. and Newsholme, P. Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line. Clin. Sci. 2003;104: 171-9.