Microbiology is presently based with, and host to, the National
Virus Reference Laboratory
(NVRL) on the Belfield Campus of University College Dublin.
of Medical Microbiology
Professor William Hall, PhD, MD
Telephone: +353-1-716 1325; email: firstname.lastname@example.org
in Medical Microbiology
Dr Jacqueline Quinn, MB, BCh, BAO, MMedSci
Telephone: +353-1-716 1339; email: email@example.com
Koon Meng Chang, MB, BCh, BAO, LRCPI, LRCSI, MRCP (UK),
Telephone: +353-1-716 1221; email: firstname.lastname@example.org
Noreen Sheehy, MSc, PhD
Telephone: +353-1-716 1255; email: email@example.com
Ms Margaret Brindley, Administrative
Telephone: +353-1-716 1236; email: firstname.lastname@example.org
Ms Denise McDonnell, Senior Executive Assistant (job-share)
Telephone: +353-1-716 1325; email: email@example.com
microbiology is involved
in designing and teaching of the second medical year (Systems 2) of the undergraduate medical curriculum and to the third
and fourth year of the microbiology undergraduate course in the Faculty of Science.
Staff also teach in Public Health Medicine and
Epidemiology, and Nursing Studies.
Microbiology is involved in postgraduate research by thesis at a
Research is a major
activity, often in collaboration with the National
Virus Reference Laboratory and within other areas in UCD, and also with hospitals and clinicians. A very significant level of
applied research is so carried out in collaboration with the diagnostics industry.
Research is carried out in the purpose-built adjoining Centre for Research in
Infectious Diseases (CRID).
In the following section,
sources of research funding are shown in italics,
Concomitant Infections with Human T Lymphotropic Viruses and Human Immunodeficiency
Japanese Foundation for AIDS Prevention, Tokyo, Japan
Molecular and Immunological Studies on Hepatitis C Virus.
Health Research Board
Development of diagnostic protocols for BVD virus
antigen and antibodies. Enterprise Ireland, Novatis and
Svanova Biotech. 2002-2004
Barrett AM, Walshe K, Kavanagh PV, McNamara SM,
Moran C, Burdett J, Shattock AG.
A comparison of five commercial immunoassays for the detection
of flunitrazepam and other benzodiazepines in urine.
Addiction Biology, 4, 81-87, 1999
Walshe K, Barrett AM, Kavanagh PV, McNamara S, Moran C, Shattock AG.
The development of a sensitive immunoassay to detect flunitrazepam and
its metabolites in urine, and confirmation by gas chromatography mass
of Analytical Toxicology, 24, 1-4 May/June 2000
AM, Hall WW, Lewis MJ, Goubau P, Salemi M. Origins of HTLV-1 in South America. Nat
Mahieux R, Pise-Masison CA, Nicot C, Green P,
Hall WW, Brady JN. Inactivation of p53 by HTLV type 1 and HTLV type 2 Tax
AIDS Res Hum Retroviruses.
Nov 1;16(16):1677-81, 2000
R, Pise-Masison CA, Lambert PF, Nicot C, De Marchis L, Gessain A,
Green P, Hall WW, Brady JN.
Differences in the ability of human T-cell
lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53
function. J Virol.
Aug; 74(15):6866-74, 2000
MJ, Novoa P, Ishak R, Ishak M, Salemi M, Vandemme AM, Kaplan MH,
Isolation, cloning, and complete nucleotide sequence
of a phenotypically distinct Brazilian isolate of human T-lymphotropic
virus type II (HTLV-II). Virology.
May 25; 271(1):142-54, 2000
MJ, Gautier VW, Wang XP, Kaplan MH, Hall WW.
Spontaneous production of C-C chemokines by
individuals infected with human T lymphotropic virus type II (HTLV-II)
alone and HTLV-II/HIV-1 coinfected individuals. J
Y, Sawa H, Tanaka S, Takada A, Suzuki S, Hasegawa H, Umemura T,
Fujisawa J, Tanaka Y, Hall WW, Nagashima K.
Transcriptional activation of JC virus by human T-lymphotropic
virus type I Tax protein in human neuronal cell lines. J
Jun 2;275(22):17016-23, 2000
CM, Cafferkey MT, Conroy A, Dooley S, Hall WW, Beckett M, Mackey R,
Clarke TA, White MJ, Gorman WA, Butler KM.
Hepatitis C infection
in an Irish antenatal population.
Irish Journal of Medical Science 169:180-2, 2000
Salemi M, Strimmer K, Hall
WW, Duffy M, Delaporte E, Mboup S, Peeters M and Vandamme AM. Dating the common ancestor of SIVcpz and HIV-group M and the
origin of HIV-1 subtypes using a new method to uncover clock-like
molecular evolution. FASEB
Su J, Naghavi MH, Jejcic A, Furuta Y, Wu
Y, Li S, Hall WW, Goobar-Larsson L Svennerholm B and Vahlne A.
The Tripeptide Glycyl-Prolyl-Glycine Amide does not affect
the early steps of the Human Immunodeficiency Virus Type 1
of Human Virology 4:8-15, 2001
Vandamme AM, Houyez F, Banhegyi D, Clotet
B, De Schrijver G, De Smet KA, Hall WW, Harrigan R, Hellmann N,
Hertogs K, Holtzer C, Larder B, Pillay D, Race E, Schmit JC,
Schuurman R, Schulse E, Sonnerborg A, and Miller V.
Laboratory guidelines for the practical use of HIV drug
resistance tests in patient follow-up. Antiviral
CM, Cafferkey MT, Conroy A, Dooley S, Hall WW, Beckett M,
Clarke TA,White MJ, Gorman WA, and
Butler KM. Outcome
of infants born to hepatitis C infected women.
Irish Journal of Medical Science 170:103-6; discussion
R, Vallinoto AC, Azevedo VN, Lewis M, Hall WW, Guimaraes Ishak MO.
Molecular evidence of mother-to-child
transmission of HTLV-IIc in the Kararao Village (Kayapo) in the
Amazon region of Brazil. Rev Soc Bras Med Trop 34(6):519-25,
K, Hirata A, Iwai K, Sakurai M, Fukushi M, Oie M, Higuchi M, Hall
WW, Gejyo F, and Fujii M. Human
T-Cell Leukemia Virus Type 2 (HTLV-2) Tax protein transforms a rat
fibroblast cell line but less efficiently than HTLV-1 tax.
Journal of Virology
MJ, Sheehy N, Salemi M, Van Damme A, and Hall WW. Comparison of CREB-and NF-kB
mediated transactivation by human T lymphotropic virus type II (HTLV-II)
and type I (HTLV-I) tax proteins.
Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW, Nagashima K, and
Kurata T. Reconstitution of cleavage of human immunodeficiency virus
type-1 (HIV-1) RNAs. Biochemical Biophysical Research
Communications 293:1084-91, 2002
Takahashi H, Sawa H, Hasegawa H, Shoya Y, Sata T, Hall WW, Nagashima
K, and Kurata T. Topoisomerase
I and ATP activate cDNA synthesis of human immunodeficiency virus
type 1. Biochemical Biophysical Research Communications
Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW and Kurata T.
Binding and dissociation of human topoisomerase I with
hairpin-loop Rnas: Implications for the regulation of HIV-1
and Biophysical Research Communications
M, Salemi M, Sheehy N, Vandamme A, Hegarty J, Curry M, Nolan N,
Kelleher D, McKiernan S, and Hall WW. Comparative
rates of nucleotide sequence variation in the hypervariable region
of E1/E2 and the NS5b region of Hepatitis C virus in patients with a
spectrum of liver disease resulting from a common source of
infection. Virology 301:354,
AJ, Duffy M, Brady MT, McKiernan S, Hall W, Hegarty J, Curry M, and
Mills KH. CD4 T helper
type 1 and regulatory T cells induced against the same epitopes on
the core protein in Hepatitis C virus-infected persons.
Journal of Infectious Diseases 185:720-7, 2002
Hasegawa H, Tatsumi M, Ogawa-Goto K, Takahashi H, Kojima A, Iwasaki
T, Kurata T, Sata T, Takeuchi T, Sheehy N, Sawa H, Nagashima K and
Hall WW. Processing of
HTLV-II envelope precursor glycoprotein gp63 by Furin is essential
for cell fusion activity. AIDS
Research and Human Retroviruses 18:17:1253-1260, 2002
Vallinoto ACR, Ishak MAG, Azevedo AN, Vicente ACP, Otsuki K, Hall
WW, and Ishak R. Molecular
epidemiology of human T-lymphotropic virus type II infection in
Amerindian and urban populations of the Amazon region of Brazil.
Human Biology 74:633-644, 2002
S, Lyons R, Ryan J, Hall W, Gallagher C. Botulisn as a cause of
respiratory failure in injecting drug users. Irish Journal of
Medical Science, 172:143-4, 2003
Lemey P, Salemi M, Wang B, Duffy M, Hall WW, Saksena NK, and
Vandamme AM. Site stripping based on likelihood ratio reduction is a
useful tool to evaluate the impact of non-clock-like behaviour on
viral phylogenetic reconstructions.
FEMS Immunology Medical Microbiology
Y, Tokunaga K, Sawa H, Maeda M, Ueno T, Yoshikawa T, Hasegawa H,
Sata T, Kurata T, Hall WW, Cullen BR, and Takahashi H.
Human topoisomerase I promotes HIV-1 proviral DNA synthesis:
implications for the species specificity and cellular tropism of
HIV-1 infection. Proceedings
of the National Academy of Sciences (USA) 100:8442-7, 2003
Araujo A, and Hall WW. Human T-lymphotropic virus type II and
neurological disease. Annals
of Neurology 56(1):10-19,
R, Hall WW, Gallego, S.
Seroepidemiology of HTLV-I/II in Argentina: an
of Acquired Immune Deficiency Syndrome 35:301-8, 2004
Araujo A, Hall WW.
Human T-lymphotropic virus type II and neurological disease.
Annals of Neurology. 56:10-19, 2004.
Martín J, Odoom K,
Tuite G, Dunn G, Hopewell N, Cooper G, Fitzharris C, Butler K, Hall
WW, Minor PD. Long-term
excretion of vaccine-derived poliovirus by a healthy child.
Journal of Virology.
Sonnerborg A, Ait-Khaled M, Albert J, Asjo B, Bacheler L, Banhegyi
D, Boucher C, Brun-Vézinet F, Camacho R, Clevenbergh P, Clumeck N,
Dedes N, De Luca A, Doerr HW, Faudon J-L, Gatti G, Gerstoft J, Hall
WW, Hatzakis A, Hellmann N, Horban A, Lundgren JD, Kempf D, Miller
M, Miller V, Myers TW, Nielson C, Opravil M, Palmisano L, Perno CF,
Phillips A, Pillay D, Pumarola T, Ruiz L, Salminen M, Schapiro J,
Schmidt B, Schmit J-C, Schuurman R, Shulse E, Soriano V, Staszewski
S, Vella S, Youle M, Ziermann R and Perrin L.
Updated European recommendations for the clinical use of HIV
drug resistance testing.
Antiviral Therapy 9 : 829-848, 2004
Lyons FE, Coughlan S,
Byrne CM, Hopkins SM, Hall WW, Mulcahy FM.
Emergence of antiretroviral resistance in HIV-positive women
receiving combination antiretroviral therapy in pregnancy. AIDS 19: 63-67, 2005
Zheng HY, Takasaka T,
Noda K, Kanazawa A, Mori H, Kabuki T, Joh K, Oh-ishi T, Hiroshi I,
Nagashima K, Hall WW, Kitamura T and Yogo Y.
New sequence polymorphisms in the outer loops of the JC virus
major capsid protein (VP1) possibly associated with progressive
Journal of General Virology 86: 2035-2045, 2005
Okada Y, Suzuki T,
Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW,
Nagashima K, Sawa H. Dissociation of heterochromatin protein 1 from
lamin B receptor induced by human polyomavirus agnoprotein: role in
nuclear egress of viral particles.
EMBO Reports 6:452-457, 2005
Sawa H, Nagashima T,
Nagashima K, Shinohara T, Chuma T, Mano Y, Tachi N, Hall WW. Clinicpathological and virological analyses of familial HTLV-I
associated polyneuropathy. Journal of Neurovirology 11: