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Medical Microbiology is presently based with, and host to, the National Virus Reference Laboratory (NVRL) on the Belfield Campus of University College Dublin. 

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Professor of Medical Microbiology
Professor William Hall, PhD, MD
Telephone: +353-1-716 1325;  email: william.hall@ucd.ie

College Lecturers in Medical Microbiology
Dr  Jacqueline Quinn, MB, BCh, BAO, MMedSci
Telephone: +353-1-716 1339;  email: jacqueline.quinn@ucd.ie

Dr Koon Meng Chang, MB, BCh, BAO, LRCPI, LRCSI, MRCP (UK),
Telephone:  +353-1-716 1221; email: meng.chan@ucd.ie 

Dr Noreen Sheehy, MSc, PhD
Telephone: +353-1-716 1255; email: noreen.sheehy@ucd.ie

Administrative Support
Ms Margaret Brindley, Administrative Officer
Telephone: +353-1-716 1236;  email: margaret.brindley@ucd.ie

Ms Denise McDonnell, Senior Executive Assistant (job-share)
Telephone: +353-1-716 1325;  email: denise.mcdonnell@ucd.ie

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Undergraduate Teaching

Medical microbiology is involved in designing and teaching of the second medical year (Systems 2) of the undergraduate medical curriculum and to the third and fourth year of the microbiology undergraduate course in the Faculty of Science. Staff also teach in Public Health Medicine and Epidemiology, and Nursing Studies.

Postgraduate Teaching

Medical Microbiology is involved in postgraduate research by thesis at a supervisory level.  

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Research is a major activity, often in collaboration with the National Virus Reference Laboratory and within other areas in UCD, and also with hospitals and clinicians. A very significant level of applied research is so carried out in collaboration with the diagnostics industry.  Research is carried out in the purpose-built adjoining Centre for Research in Infectious Diseases (CRID).   

In the following section, sources of research funding are shown in italics,

Concomitant Infections with Human T Lymphotropic Viruses and Human Immunodeficiency Viruses
Japanese Foundation for AIDS Prevention, Tokyo, Japan

Molecular and Immunological Studies on Hepatitis C Virus.
Health Research Board

NEW PROJECTS:

Development of diagnostic protocols for BVD virus antigen and antibodies.  Enterprise Ireland, Novatis and Svanova Biotech.  2002-2004

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PUBLICATIONS:

Barrett AM, Walshe K, Kavanagh PV, McNamara SM, Moran C, Burdett J, Shattock AG.  A comparison of five commercial immunoassays for the detection of flunitrazepam and other benzodiazepines in urine.  Addiction Biology,  4, 81-87, 1999

Walshe K, Barrett AM, Kavanagh PV, McNamara S, Moran C, Shattock AG.  The development of a sensitive immunoassay to detect flunitrazepam and its metabolites in urine, and confirmation by gas chromatography mass spectroscopy.   Journal of Analytical Toxicology, 24, 1-4 May/June 2000

Vandamme AM, Hall WW, Lewis MJ, Goubau P, Salemi M.  Origins of HTLV-1 in South America. Nat Med.  Mar;6(3):232-3, 2000.  

Mahieux R, Pise-Masison CA, Nicot C, Green P, Hall WW, Brady JN. Inactivation of p53 by HTLV type 1 and HTLV type 2 Tax trans-activators.
AIDS Res Hum Retroviruses.  Nov 1;16(16):1677-81, 2000

Mahieux R, Pise-Masison CA, Lambert PF, Nicot C, De Marchis L, Gessain A, Green P, Hall WW, Brady JN. Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function. J Virol.  Aug; 74(15):6866-74, 2000  

Lewis MJ, Novoa P, Ishak R, Ishak M, Salemi M, Vandemme AM, Kaplan MH, Hall WW. Isolation, cloning, and complete nucleotide sequence of a phenotypically distinct Brazilian isolate of human T-lymphotropic virus type II (HTLV-II).  Virology.  May 25; 271(1):142-54, 2000

Lewis MJ, Gautier VW, Wang XP, Kaplan MH, Hall WW. Spontaneous production of C-C chemokines by individuals infected with human T lymphotropic virus type II (HTLV-II) alone and HTLV-II/HIV-1 coinfected individuals.  J Immunol. Oct 1;165(7):4127-32, 2000

Okada Y, Sawa H, Tanaka S, Takada A, Suzuki S, Hasegawa H, Umemura T, Fujisawa J, Tanaka Y, Hall WW, Nagashima K. Transcriptional activation of JC virus by human T-lymphotropic virus type I Tax protein in human neuronal cell lines.  J Biol Chem.  Jun 2;275(22):17016-23, 2000

Healy CM, Cafferkey MT, Conroy A, Dooley S, Hall WW, Beckett M, Mackey R, Clarke TA, White MJ, Gorman WA, Butler KM.  Hepatitis C infection in an Irish antenatal population.  Irish Journal of Medical Science 169:180-2, 2000


Salemi M, Strimmer K, Hall WW, Duffy M, Delaporte E, Mboup S, Peeters M and Vandamme AM.  Dating the common ancestor of SIVcpz and HIV-group M and the origin of HIV-1 subtypes using a new method to uncover clock-like molecular evolution. FASEB Journal  2:276-8, 2001

Su J, Naghavi MH, Jejcic A, Furuta Y, Wu Y, Li S, Hall WW, Goobar-Larsson L Svennerholm B and Vahlne A.  The Tripeptide Glycyl-Prolyl-Glycine Amide does not affect the early steps of the Human Immunodeficiency Virus Type 1 Replication.  Journal of Human Virology 4:8-15, 2001

Vandamme AM, Houyez F, Banhegyi D, Clotet B, De Schrijver G, De Smet KA, Hall WW, Harrigan R, Hellmann N, Hertogs K, Holtzer C, Larder B, Pillay D, Race E, Schmit JC, Schuurman R, Schulse E, Sonnerborg A, and Miller V.  Laboratory guidelines for the practical use of HIV drug resistance tests in patient follow-up. Antiviral Therapy 1:21-39, 2001

Healy CM, Cafferkey MT, Conroy A, Dooley S, Hall WW, Beckett M, Clarke TA,White MJ, Gorman WA, and  Butler KM.  Outcome of infants born to hepatitis C infected women.  Irish Journal of Medical Science 170:103-6; discussion 92-3, 2001

Ishak R, Vallinoto AC, Azevedo VN, Lewis M, Hall WW, Guimaraes Ishak MO. Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon region of Brazil. Rev Soc Bras Med Trop 34(6):519-25, 2001

Endo K, Hirata A, Iwai K, Sakurai M, Fukushi M, Oie M, Higuchi M, Hall WW, Gejyo F, and Fujii M.  Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 tax.  Journal of Virology  76:2648-2653, 2002

Lewis MJ, Sheehy N, Salemi M, Van Damme A, and Hall WW.  Comparison of CREB-and NF-kB mediated transactivation by human T lymphotropic virus type II (HTLV-II) and type I (HTLV-I) tax proteins.  Virology  30:295(1):182-9, 2002

Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW, Nagashima K, and Kurata T. Reconstitution of cleavage of human immunodeficiency virus type-1 (HIV-1) RNAs. Biochemical Biophysical Research Communications 293:1084-91, 2002

Takahashi H, Sawa H, Hasegawa H, Shoya Y, Sata T, Hall WW, Nagashima K, and Kurata T.  Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type 1. Biochemical Biophysical Research Communications 294:509-17, 2002

Coughlan S, Connell J, Cohen B, Jin L, and Hall WW.  Sub optimal MMR vaccination coverage facilitates an imported measles outbreak in Ireland.  Clinical Infectious Diseases 35:84-6, 2002

Ijichi S, Ijichi N, Osame M, and Hall WW.  In vivo induction of human immunodeficiency virus type 1 entry into nucleus-free cells by CD4 gene transfer to hematopoietic stem cells: A hypothetical possible strategy for therapeutic intervention.  Medical Hypotheses 59:24-34, 2002

Takahashi H, Sawa H, Hasegawa H, Sata T, Hall WW and Kurata T.  Binding and dissociation of human topoisomerase I with hairpin-loop Rnas: Implications for the regulation of HIV-1 replication.  Biochemical and Biophysical Research Communications  297:593-599, 2002

Duffy M, Salemi M, Sheehy N, Vandamme A, Hegarty J, Curry M, Nolan N, Kelleher D, McKiernan S, and Hall WW.  Comparative rates of nucleotide sequence variation in the hypervariable region of E1/E2 and the NS5b region of Hepatitis C virus in patients with a spectrum of liver disease resulting from a common source of infection. Virology  301:354, 2002

MacDonald AJ, Duffy M, Brady MT, McKiernan S, Hall W, Hegarty J, Curry M, and Mills KH.  CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in Hepatitis C virus-infected persons.  Journal of Infectious Diseases 185:720-7, 2002

Hasegawa H, Tatsumi M, Ogawa-Goto K, Takahashi H, Kojima A, Iwasaki T, Kurata T, Sata T, Takeuchi T, Sheehy N, Sawa H, Nagashima K and Hall WW.  Processing of HTLV-II envelope precursor glycoprotein gp63 by Furin is essential for cell fusion activity. AIDS Research and Human Retroviruses  18:17:1253-1260, 2002

Vallinoto ACR, Ishak MAG, Azevedo AN, Vicente ACP, Otsuki K, Hall WW, and Ishak R.  Molecular epidemiology of human T-lymphotropic virus type II infection in Amerindian and urban populations of the Amazon region of Brazil.  Human Biology 74:633-644, 2002  

FitzGerald S, Lyons R, Ryan J, Hall W, Gallagher C. Botulisn as a cause of respiratory failure in injecting drug users. Irish Journal of Medical Science, 172:143-4, 2003

Curry MP, Golden-Mason L, Doherty DG, Deignan T, Norris S, Duffy M, Nolan N, Hall WW, Hegarty JE, and O'Farrelly C.  Expansion of innate CD5 (pos) B cells expressing high levels of CD81 in hepatitis C virus infected liver. Journal of Hepatology 38:642-50, 2003

Lemey P, Salemi M, Wang B, Duffy M, Hall WW, Saksena NK, and Vandamme AM. Site stripping based on likelihood ratio reduction is a useful tool to evaluate the impact of non-clock-like behaviour on viral phylogenetic reconstructions.  FEMS Immunology Medical Microbiology  39:125-32, 2003

Shoya Y, Tokunaga K, Sawa H, Maeda M, Ueno T, Yoshikawa T, Hasegawa H, Sata T, Kurata T, Hall WW, Cullen BR, and Takahashi H.  Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection.  Proceedings of the National Academy of Sciences (USA) 100:8442-7, 2003

Araujo A, and Hall WW.  Human T-lymphotropic virus type II and neurological disease.  Annals of Neurology  56(1):10-19, 2004  

Gastaldello R, Hall WW, Gallego, S.   Seroepidemiology of HTLV-I/II in Argentina: an overview.  Journal of Acquired Immune Deficiency Syndrome 35:301-8, 2004

Araujo A, Hall WW. Human T-lymphotropic virus type II and neurological disease.  Annals of Neurology. 56:10-19, 2004.

Martín J, Odoom K, Tuite G, Dunn G, Hopewell N, Cooper G, Fitzharris C, Butler K, Hall WW, Minor PD.  Long-term excretion of vaccine-derived poliovirus by a healthy child.  Journal of Virology.  78:13839-1384, 2004

Vandamme A-M, Sonnerborg A, Ait-Khaled M, Albert J, Asjo B, Bacheler L, Banhegyi D, Boucher C, Brun-Vézinet F, Camacho R, Clevenbergh P, Clumeck N, Dedes N, De Luca A, Doerr HW, Faudon J-L, Gatti G, Gerstoft J, Hall WW, Hatzakis A, Hellmann N, Horban A, Lundgren JD, Kempf D, Miller M, Miller V, Myers TW, Nielson C, Opravil M, Palmisano L, Perno CF, Phillips A, Pillay D, Pumarola T, Ruiz L, Salminen M, Schapiro J, Schmidt B, Schmit J-C, Schuurman R, Shulse E, Soriano V, Staszewski S, Vella S, Youle M, Ziermann R and Perrin L.  Updated European recommendations for the clinical use of HIV drug resistance testing.   Antiviral Therapy 9 : 829-848, 2004

Lyons FE, Coughlan S, Byrne CM, Hopkins SM, Hall WW, Mulcahy FM.  Emergence of antiretroviral resistance in HIV-positive women receiving combination antiretroviral therapy in pregnancy.  AIDS 19: 63-67, 2005

Zheng HY, Takasaka T, Noda K, Kanazawa A, Mori H, Kabuki T, Joh K, Oh-ishi T, Hiroshi I, Nagashima K, Hall WW, Kitamura T and Yogo Y.  
New sequence polymorphisms in the outer loops of the JC virus major capsid protein (VP1) possibly associated with progressive multifocal leukoencephalopathy.  Journal of General Virology 86: 2035-2045, 2005

Okada Y, Suzuki T, Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW, Nagashima K, Sawa H. Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles.  EMBO Reports 6:452-457, 2005

Sawa H, Nagashima T, Nagashima K, Shinohara T, Chuma T, Mano Y, Tachi N, Hall WW.  Clinicpathological and virological analyses of familial HTLV-I associated polyneuropathy. Journal of Neurovirology 11: 199-207, 2005

 

 

 

 



 

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Postal address:                           
Medical Microbiology,
CRID Building,
University College Dublin,                                      

Belfield,
Dublin 4,
Ireland.
Telephone Number: +353-1-716 1325/1236
Fax Number: +353-1-716 1239
Email: margaret.brindley@ucd.ie

© Copyright Faculty of Medicine, U.C.D. 2004