Researcher Profiles

Dr. Craig Slattery - Senior Scientist and Research Coordinator

Craig holds a PhD in Pharmacology and has extensive experience in working with animal and cell culture models of renal disease.† His primary research interest is in the development of kidney disorders with particular focus on diabetic nephropathy, proteinuria, drug-induced nephrotoxicity and renal cancers.

Craig is currently a Government of Ireland Research Fellow funded by the Irish Research Council for Science, Engineering and Technology.

E-mail: craig.slattery@ucd.ie†

Mr. Robert Radford - Graduate Researcher & PhD Candidate

Robertís research is part the carcinoGENOMICS project and the primary goal is the development of in vitro alternatives to animal models for carcinogenicity screening. He is utilising metabonomic, transcriptomic and cytomic analyses to develop a robust human† renal cell culture model system for carcinogen screening.† This will ultimately contribute to the development of a high throughput, cost-effective alternative to the two year rodent model which is currently used.†

In addition, Robertís research is focusing on† characterizing the molecular mechanisms of chemical carcinogenesis with particular focus on ochratoxin A and potassium bromate.

E-mail: robert.radford@ucdconnect.ie

Ms. Hilary Cassidy - Graduate Researcher & PhD Candidate

Hilaryís research aims to identify potential biomarkers of kidney disease in immunosupressant induced chronic allograft nephropathy. Her research utilises metabolomic and proteomic techniques such as NMR and mass spectrometry to investigate clinical samples for potential novel biomarkers of renal damage. Cytomic analyses investigate the cellular effects of immunosuppressant treatments on renal proximal tubule cells and also further investigate identified biomarkers and their role in kidney damage. The overall aim is the development of novel diagnostic and prognostic tools for earlier, sensitive detection of changes in transplant patient renal function.†

E-mail: hilary.cassidy@ucdconnect.ie

Ms. Jennifer Slyne - Graduate Researcher & PhD Candidate

Jenniferís research programme is part of the SysKid project which aims to understand the development and progression of chronic kidney disease in the context of diabetes and hypertension. Her research utilises cell culture models to investigate the cellular effects of identified biomarkers and the processes associated with early kidney disease with the aim of developing novel diagnostic and prognostic tools for patient Jennifer is also investigating the potential role of microRNAs in diabetic nephropathy.

 

 

E-mail: jennifer.slyne@ucdconnect.ie

Ms. Helena Frain - Graduate Researcher & PhD Candidate

Helenaís research is part of the renal toxicogenomics project and is a CEFIC funded programme. The primary aim of the project is to predict systemic repeated dose in vivo toxicity in kidney from in vitro toxicogenomics experiments both from a mechanistic and potency perspective. This may subsequently lead to a reduction in animal models being used. This research involves testing chemicals on the RPTEC/TERT1 human proximal tubular epithelial cell line and then using microarray analysis as well as a bioinformatic approach to try to identify new toxicity pathway based paradigms. Results that are generated will be integrated into existing in vivo databases.

E-mail: helena.frain@ucdconnect.ie

Ms. Bernadette McEvoy - Graduate Researcher & PhD Candidate

Bernadetteís research focuses on the autosomal recessive, lysosomal storage disease, cystinosis. Her project, funded by Cystinosis Foundation Ireland and the Health Research Board, investigates how the cystine accumulation associated with cystinosis, leads to pancreatic beta cell dysfunction and muscle myopathy. This is achieved using established cell lines and knocking down the production of cystinosin,† the defective protein in cystinosis. Following protein knockdown, the effect of cystine accumulation on cell function, gene expression, cellular redox status and other cellular processes is investigated. From these studies, possible mechanisms to reduce cellular dysfunction and damage will be identified.

E-mail: bernadette.mc-evoy@ucdconnect.ie