The Proteome Research Centre at UCD’s Conway Institute has been appointed as a reference centre for a new protein stabilising technology. The new technology, Denator Stabilizor™ T1 system, stabilises tissue samples from the moment of sampling, preventing degradation of proteins and peptides which, until now, has been a major obstacle in proteomic research.
Protein and peptide degradation begins when a biological specimen is sampled, potentially causing the distortion or destruction of vital information about the original biological state. This can lead to inter-sample variation and the risk of incorrect data interpretation. Swedish biotechnology company, Denator is using patent-pending technology to halt the degradation process and maintain sample stability.
Prof Michael Dunn at the UCD Conway Proteome Research Centre, explained, ‘Degradation begins seconds after sampling, thereby distorting the composition of the in vivo proteome. Denator’s rapid heat inactivation technology ensures complete elimination of enzymatic activity, thereby preserving the intact proteome. This will be an important tool that will help to further our understanding of the molecular basis of biological processes in health and disease.’
Olof Sköld, CEO at Denator, concluded: ‘We are very pleased that UCD Conway has decided to implement Stabilizor T1 in their eminent research activities, but above all we’re excited that UCD Conway will become reference centre for the Stabilizor system. Degradation of proteins and peptides during sample preparation is a major bottleneck in proteomic research today.”
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