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Researchers at UCD

researcher

Emmeline Hill

Associate Professor

School Of Agriculture & Food Science
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166231
Email: emmeline.hill@ucd.ie

Biography

1991-1995: BA (mod Genetics), Trinity College Dublin
1995-1999: Ph.D., Trinity College Dublin
1998-1999: Research Associate, International Livestock Research Institute, Kenya
1999-2000: Research Consultant, FAO of the United Nations
2000-2001: Postdoctoral Researcher, Trinity College Dublin
2002-2004: Postdoctoral Researcher, University College Dublin
2004-2010: Science Foundation Ireland President of Ireland Young Researcher Award
2009: Co-founder Equinome Ltd
2004: College Lecturer in Equine Science
2012-2017: Science Foundation Ireland Principal Investigator Award
2014: Senior Lecturer in Equine Science
2015: Chief Science Officer Plusvital Ltd
2016: Associate Professor of Equine Science


Professional

Honours and Awards

Year: 2016.
Title: SFI Best Reported Impact Award
Year: 2011.
Title: Business Entrepreneur of the Year Award
Year: 2010.
Title: Entrepreneur of the Year Award
Year: 2009.
Title: Campus Company Development Programme Start-Up Award
Year: 2004.
Title: President of Ireland Young Researcher Award
Year: 2012.
Title: Irish Tatler Entrepreneur of the Year Award
Year: 2014.
Title: UCD Innovation Award

Associations

Association: International Womens Forum, Function/Role: Member
 

Disclosures

Predictive genetic markers for height in Thoroughbred horses. Inventor(s):Hill, Katz, Herdan, Submitted: 01-DEC-15
A major risk locus and other predictive genetic markers for Recurrent Laryngeal Neuropathy in Thoroughbred horses.. Inventor(s):Hill, Katz, Herdan, Submitted: 01-DEC-15
A genotype-specific nutraceutical for horses.. Inventor(s):Hill, Katz, Rooney, Porter, Submitted: 31-AUG-15

Licensing

Supplementation of specific horse genotypes with a co-enzyme. Inventor(s):Hill, Katz, Porter, Rooney, Licensee:Plusvital Ltd
 

Committees

Committee : Board of Assessors
Committee : Board of Assessors
Committee : Timetable Committee
Committee : Curriculum Committee
Committee : Mature Student Assessment Committee
 

Education

Year 1995 Institution:
Qualification: BA Subject:
Year 1999 Institution:
Qualification: PhD Subject:
         

Publications

Books

Hill, E.W. and Katz, L.M. and Machugh, D.E. (2013) Genomics of Performance. : Blackwell Publishing Ltd. [DOI] [Details]
Hill, E.W. and Katz, L.M. and Machugh, D.E. (2013) Genomics of Performance. : Blackwell Publishing Ltd. [DOI] [Details]

Book Chapters

Hill EW, Katz LM, MacHugh DE; (2013) 'Genomics of Performance' In: Chowdhary B (eds). Equine Genomics. Hoboken, NJ: Wiley-Blackwell. , pp.265-284 [Details]
 

Peer Reviewed Journals

Meade, K.G., Hill, E.W., Buckley, F., MacHugh, D.E.; (2005) 'Convenient detection of single nucleotide polymorphism (SNP) haplotypes in the bovine growth hormone gene using amplification-created restriction sites (ACRS)'. Animal Genetics, 36 (2):175-177. [Details]
Meade, K. G.,Hill, E. W.,Buckley, F.,MacHugh, D. E.; (2005) 'Convenient detection of single nucleotide polymorphism haplotypes in the bovine growth hormone gene using amplification-created restriction sites'. Anim Genet, 36 (2):175-7. [Details]
Meade, K. G., Hill, E. W., Buckley, F., MacHugh, D. E. (2005) 'Convenient detection of single nucleotide polymorphism haplotypes in the bovine growth hormone gene using amplification-created restriction sites'. Animal Genetics, 36 (2):175-177. Available Online [Details]
Hill, E. W., O'Gorman, G. M., Agaba, M., Gibson, J. P., Hanotte, O., Kemp, S. J., Naessens, J., Coussens, P. M., MacHugh, D. E. (2005) 'Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics'. Veterinary Immunology and Immunopathology, 105 (3-4):247-258. Available Online [Details]
Hill, EW; O'Gorman, GM; Agaba, M; Gibson, JP; Hanotte, O; Kemp, SJ; Naessens, J; Coussens, PM; MacHugh, DE; ; (2005) 'Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics'. Veterinary Immunology and Immunopathology, 105 (3-4):247-258. [Details]
Hill, EW,O'Gorman, GM,Agaba, M,Gibson, JP,Hanotte, O,Kemp, SJ,Naessens, J,Coussens, PM,MacHugh, DE; (2005) 'Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics'. Veterinary Immunology and Immunopathology, 105 :247-258. [DOI] [Details]
McGahern, A.M., Edwards, C.J., Bower, M.A., Heffernan, A., Park, S.D., Brophy, P.O., Bradley, D.G., MacHugh, D.E., & Hill, E.W.; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. ANIMAL GENETICS, 37 (5):498-502. [Details]
McGahern, A., Bower, M.A., Edwards, C.J., Brophy, P.O., Sulimova, G., Zakharov, I., Vizuete-Forster, M., Levine, M., Li, S., Machugh, D.E., Hill, E.W.; (2006) 'Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations'. Animal Genetics, 37 (5):494-7. [Details]
O'Gorman GM, Park SD, Hill EW, Meade KG, Mitchell LC, Agaba M, Gibson JP, Hanotte O, Naessens J, Kemp SJ, MacHugh DE.; (2006) 'Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense'. Physiological Genomics, 28 (1):53-61. [Details]
O'Gorman, G. M.,Park, S. D.,Hill, E. W.,Meade, K. G.,Mitchell, L. C.,Agaba, M.,Gibson, J. P.,Hanotte, O.,Naessens, J.,Kemp, S. J.,MacHugh, D. E.; (2006) 'Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense'. Physiol Genomics, 28 (1):53-61. [Details]
McGahern, A. M., Edwards, C. J., Bower, M. A., Heffernan, A., Park, S. D. E., Brophy, P. O., Bradley, D. G., MacHugh, D. E., Hill, E. W. (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Animal Genetics, 37 (5):498-502. Available Online [Details]
McGahern, A., Bower, M. A. M., Edwards, C. J., Brophy, P. O., Sulimova, G., Zakharov, I., Vizuete-Forster, M., Levine, M., Li, S., MacHugh, D. E., Hill, E. W. (2006) 'Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations'. Animal Genetics, 37 (5):494-497. Available Online [Details]
McGahern, AM; Edwards, CJ; Bower, MA; Heffernan, A; Park, SDE; Brophy, PO; Bradley, DG; MacHugh, DE; Hill, EW; ; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Animal Genetics, 37 (5):498-502. [Details]
O'Gorman, GM; Park, SDE; Hill, EW; Meade, KG; Mitchell, LC; Agaba, M; Gibson, JP; Hanotte, O; Naessens, J; Kemp, SJ; MacHugh, DE; ; (2006) 'Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense'. Physiological Genomics, 28 (1):53-61. [Details]
McGahern, A.M., Edwards, C.J., Bower, M.A., Heffernan, A., Park, S.D.E., Brophy, P.O., Bradley, D.G., MacHugh, D.E., Hill, E.W.; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Animal Genetics, 37 (5):498-502. [Details]
McGahern, A,Bower, MAM,Edwards, CJ,Brophy, PO,Sulimova, G,Zakharov, I,Vizuete-Forster, M,Levine, M,Li, S,MacHugh, DE,Hill, EW; (2006) 'Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations'. Gene, 37 :494-497. [DOI] [Details]
McGahern, AM,Edwards, CJ,Bower, MA,Heffernan, A,Park, SDE,Brophy, PO,Bradley, DG,MacHugh, DE,Hill, EW; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Gene, 37 :498-502. [DOI] [Details]
O¿Gorman, G.M., Park, S.D.E. Hill, E.W. Meade, K.G. Coussens, P.M. Agaba, M., Naessens, J., Kemp, S.J., MacHugh, D.E.; (2008) 'Gene expression changes in peripheral blood mononuclear cells (PBMC) from African cattle infected with Trypanosoma congolense0 revealed by transcriptional profiling'. BMC Genomics, (in press) . [Details]
Meade KG, O'Gorman GM, Hill EW, Narciandi F, Agaba M, Kemp SJ, O'Farrelly C, MacHugh DE; (2009) 'Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle'. Molecular immunology, 47 :196-204. Available Online [DOI] [Details]
McGivney, B. A.,Eivers, S. S.,MacHugh, D. E.,MacLeod, J. N.,O'Gorman, G. M.,Park, S. D.,Katz, L. M.,Hill, E. W.; (2009) 'Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy'. BMC Genomics, 10 :638638. Available Online [Details]
Gu, J.,Orr, N.,Park, S. D.,Katz, L. M.,Sulimova, G.,MacHugh, D. E.,Hill, E. W.; (2009) 'A genome scan for positive selection in thoroughbred horses'. PLoS One, 4 (66). Available Online [Details]
O'Gorman, G. M.,Park, S. D.,Hill, E. W.,Meade, K. G.,Coussens, P. M.,Agaba, M.,Naessens, J.,Kemp, S. J.,MacHugh, D. E.; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. BMC Genomics, 10 :207207. Available Online [Details]
Gu, JJ,Orr, N,Park, SD,Katz, LM,Sulimova, G,MacHugh, DE,Hill, EW; (2009) 'A Genome Scan for Positive Selection in Thoroughbred Horses'. PLoS ONE, 4 . [DOI] [Details]
Meade, KG,O'Gorman, GM,Hill, EW,Narciandi, F,Agaba, M,Kemp, SJ,O'Farrelly, C,MacHugh, DE; (2009) 'Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle'. Molecular Immunology, 47 :196-204. [DOI] [Details]
Wade, CM,Giulotto, E,Sigurdsson, S,Zoli, M,Gnerre, S,Imsland, F,Lear, TL,Adelson, DL,Bailey, E,Bellone, RR,Blocker, H,Distl, O,Edgar, RC,Garber, M,Leeb, T,Mauceli, E,MacLeod, JN,Penedo, MCT,Raison, JM,Sharpe, T,Vogel, J,Andersson, L,Antczak, DF,Biagi, T,Binns, MM,Chowdhary, BP,Coleman, SJ,Della Valle, G,Fryc, S,Guerin, G,Hasegawa, T,Hill, EW,Jurka, J,Kiialainen, A,Lindgren, G,Liu, J,Magnani, E,Mickelson, JR,Murray, J,Nergadze, SG,Onofrio, R,Pedroni, S,Piras, MF,Raudsepp, T,Rocchi, M,Roed, KH,Ryder, OA,Searle, S,Skow, L,Swinburne, JE,Syvanen, AC,Tozaki, T,Valberg, SJ,Vaudin, M,White, JR,Zody, MC,Lander, ES,Lindblad-Toh, K,Broad Inst Genome Sequencing Perfo,Broad Inst Whole Genome Assembly T; (2009) 'Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse'. Science AAAS, 326 :865-867. [DOI] [Details]
O'Gorman, GM,Park, SDE,Hill, EW,Meade, KG,Coussens, PM,Agaba, M,Naessens, J,Kemp, SJ,MacHugh, DE; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. Genomics, 10 . [DOI] [Details]
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, Ducro B, Van Arendonk JA, MacHugh DE, Ennis S, Hill EW, Brama PA (2010) 'Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses'. Gene, 41 Suppl 2 :2-7. [DOI] [Details]
Eivers, S. S.,McGivney, B. A.,Fonseca, R. G.,MacHugh, D. E.,Menson, K.,Park, S. D.,Rivero, J. L.,Taylor, C. T.,Katz, L. M.,Hill, E. W.; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiological genomics, 40 (2):83-93. Available Online [Details]
Eivers, S. S., McGivney, B. A., Fonseca, R. G., MacHugh, D. E., Menson, K., Park, S. D., Rivero, J. L. L., Taylor, C. T., Katz, L. M., Hill, E. W. (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exersise and training (vol 40, pg 83, 2010)'. Physiological Genomics, 41 (2):201-201. Available Online [Details]
Hill, EW,Gu, JJ,Eivers, SS,Fonseca, RG,McGivney, BA,Govindarajan, P,Orr, N,Katz, LM,MacHugh, D; (2010) 'A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses'. PLoS ONE, 5 . [DOI] [Details]
Eivers, SS,McGivney, BA,Fonseca, RG,MacHugh, DE,Menson, K,Park, SD,Rivero, JLL,Taylor, CT,Katz, LM,Hill, EW; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Genomics, 40 :83-93. [DOI] [Details]
McGivney, BA,McGettigan, PA,Browne, JA,Evans, ACO,Fonseca, RG,Loftus, BJ,Lohan, A,MacHugh, DE,Murphy, BA,Katz, LM,Hill, EW; (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 . [DOI] [Details]
Hill, EW,McGivney, BA,Gu, JJ,Whiston, R,MacHugh, DE; (2010) 'A genome-wide SNP-association study confirms a sequence variant (g.66493737C > T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses'. BMC Genomics, 11 . [DOI] [Details]
Gu, J,MacHugh, DE,McGivney, BA,Park, SDE,Katz, LM,Hill, EW; (2010) 'Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses'. Equine Veterinary Journal, 42 :569-575. [DOI] [Details]
Hill, EW,Eivers, SS,McGivney, BA,Fonseca, RG,Gu, J,Smith, NA,Browne, JA,MacHugh, DE,Katz, LM; (2010) 'Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle'. Equine Veterinary Journal, 42 :576-581. [DOI] [Details]
Fonseca, RG,Kenny, DA,Hill, EW,Katz, LM; (2010) 'The association of various speed indices to training responses in Thoroughbred flat racehorses measured with a global positioning and heart rate monitoring system'. Equine Veterinary Journal, 42 :51-57. [DOI] [Details]
Hill, EW,Gu, J,McGivney, BA,MacHugh, DE; (2010) 'Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance'. Animal Genetics, 41 :56-63. [DOI] [Details]
Hill, E.W., Fonseca, R.G., McGivney, B.A., Gu, J., MacHugh, D.E., Katz, L.M.; (2011) 'MSTN genotype (g. 66493737 C>T) association with speed indices in Thoroughbred racehorses'. Journal of Applied Physiology, . Available Online [DOI] [Details]
Bower, MA,Campana, MG,Whitten, M,Edwards, CJ,Jones, H,Barrett, E,Cassidy, R,Nisbet, RER,Hill, EW,Howe, CJ,Binns, M; (2011) 'The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish native mares'. Biology Letters, 7 :316-320. [DOI] [Details]
Tozaki, T,Sato, F,Hill, EW,Miyake, T,Endo, Y,Kakoi, H,Gawahara, H,Hirota, K,Nakano, Y,Nambo, Y,Kurosawa, M (2011) 'Sequence Variants at the myostatin Gene Locus Influence the Body Composition of Thoroughbred Horses'. Journal of Veterinary Medical Science, 73 :1617-1624. [Details]
M. A. Bower, B. A. McGivney, M. G. Campana, J. Gu, L. S. Andersson, E. Barrett, C. R. Davis, S. Mikko, F. Stock, V. Voronkova, D. G. Bradley, A. G. Fahey, G. Lindgren, D. E. MacHugh, G. Sulimova and E. W. Hill; (2012) 'The genetic origin and history of speed in the Thoroughbred racehorse'. Nature Communications, 3 :643. Available Online [DOI] [Details]
Hill, E. W., Ryan, D. P., MacHugh, D. E. (2012) 'Horses for Courses: a DNA-based Test for Race Distance Aptitude in Thoroughbred Racehorses'. Recent Patents on DNA and Gene Sequences, 6 (3):203-8. Available Online [Details]
Eivers, S. S., McGivney, B. A., Gu, J., MacHugh, D. E., Katz, L. M., Hill, E. W. (2012) 'PGC-1 alpha encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise'. Animal Genetics, 43 (2):153-162. Available Online [Details]
Hill, EW,Fonseca, RG,McGivney, BA,Gu, JJ,MacHugh, DE,Katz, LM (2012) 'MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses'. Journal of Applied Physiology, 112 :86-90. [DOI] [Details]
Tozaki, T,Hill, EW,Hirota, K,Kakoi, H,Gawahara, H,Miyake, T,Sugita, S,Hasegawa, T,Ishida, N,Nakano, Y,Kurosawa, M (2012) 'A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18'. Animal Genetics, 43 :42-52. [DOI] [Details]
Bower, MA,McGivney, BA,Campana, MG,Gu, JJ,Andersson, LS,Barrett, E,Davis, CR,Mikko, S,Stock, F,Voronkova, V,Bradley, DG,Fahey, AG,Lindgren, G,MacHugh, DE,Sulimova, G,Hill, EW (2012) 'The genetic origin and history of speed in the Thoroughbred racehorse'. Nature Communications, 3 . [DOI] [Details]
McCue, ME,Bannasch, DL,Petersen, JL,Gurr, J,Bailey, E,Binns, MM,Distl, O,Guerin, G,Hasegawa, T,Hill, EW,Leeb, T,Lindgren, G,Penedo, MCT,Roed, KH,Ryder, OA,Swinburne, JE,Tozaki, T,Valberg, SJ,Vaudin, M,Lindblad-Toh, K,Wade, CM,Mickelson, JR (2012) 'A High Density SNP Array for the Domestic Horse and Extant Perissodactyla: Utility for Association Mapping, Genetic Diversity, and Phylogeny Studies'. PLoS Genetics, 8 . [DOI] [Details]
Eivers, SS,McGivney, BA,Gu, J,MacHugh, DE,Katz, LM,Hill, EW (2012) 'PGC-1 alpha encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise'. Animal Genetics, 43 :153-162. [DOI] [Details]
Bower, MA,Campana, MG,Nisbet, RER,Weller, R,Whitten, M,Edwards, CJ,Stock, F,Barrett, E,O'Connell, TC,Hill, EW,Wilson, AM,Howe, CJ,Barker, G,Binns, M (2012) 'TRUTH IN THE BONES: RESOLVING THE IDENTITY OF THE FOUNDING ELITE THOROUGHBRED RACEHORSES'. Archaeometry, 54 :916-925. [DOI] [Details]
McGivney, BA,Browne, JA,Fonseca, RG,Katz, LM,MacHugh, DE,Whiston, R,Hill, EW (2012) 'MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance'. Animal Genetics, 43 :810-812. [DOI] [Details]
Moridi, M,Masoudi, AA,Torshizi, RV,Hill, EW (2013) 'Mitochondrial DNA D-loop sequence variation in maternal lineages of Iranian native horses'. Animal Genetics, 44 :209-213. [DOI] [Details]
Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara Machado A, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MC, Piercy RJ, Raekallio M, Rieder S, Røed KH, Silvestrelli M, Swinburne J, Tozaki T, Vaudin M, M Wade C, McCue ME (2013) 'Genetic diversity in the modern horse illustrated from genome-wide SNP data'. PLoS ONE, 8 (1). [DOI] [Details]
Petersen, JL,Mickelson, JR,Rendahl, AK,Valberg, SJ,Andersson, LS,Axelsson, J,Bailey, E,Bannasch, D,Binns, MM,Borges, AS,Brama, P,Machado, AD,Capomaccio, S,Cappelli, K,Cothran, EG,Distl, O,Fox-Clipsham, L,Graves, KT,Guerin, G,Haase, B,Hasegawa, T,Hemmann, K,Hill, EW,Leeb, T,Lindgren, G,Lohi, H,Lopes, MS,McGivney, BA,Mikko, S,Orr, N,Penedo, MCT,Piercy, RJ,Raekallio, M,Rieder, S,Roed, KH,Swinburne, J,Tozaki, T,Vaudin, M,Wade, CM,Mccue, ME (2013) 'Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds'. PLoS Genetics, 9 . [DOI] [Details]
Bower MA, Whitten M, Nisbet RE, Spencer M, Dominy KM, Murphy AM, Cassidy R, Barrett E, Hill EW, Binns M. (2013) 'Thoroughbred racehorse mitochondrial DNA demonstrates closer than expected links between maternal genetic history and pedigree records'. Journal of Animal Breeding and Genetics, 130 (3):227-235. [DOI] [Details]
Fonseca RG, Kenny DA, Hill EW, Katz LM. (2013) 'The relationship between body composition, training and race performance in a group of Thoroughbred flat racehorses'. Equine Veterinary Journal, . [DOI] [Details]
Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., Brama, P. A. (2013) 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10'. Animal Genetics, 44 (4):408-12. [Details]
Lisa M. Katz, Louise A. Mooney, Katie Gough, Charlotte L. McGivney, Maureen McCoughlan, Emmeline W. Hill, Heinrich Anhold (2016) 'Evaluation of a portable analyzer for determining hemoglobin concentrations and oxygen saturation in whole-blood samples from domestic animals'. Journal of Equine Veterinary Science, :64-72. [DOI] [Details]
Rivero JL, Hill EW. (2016) 'Skeletal muscle adaptations and muscle genomics of performance horses'. Veterinary Journal, 209 :5-13. [Details]
Hill EW, Gu J, Eivers SS, Fonseca RG, McGivney BA, Govindarajan P, Orr N, Katz LM, MacHugh DE; (2010) 'A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses'. PLoS ONE, 5 (1):null-null. Available Online [DOI] [Details]
Eivers SS, McGivney BA, Fonseca RG, MacHugh DE, Menson K, Park SD, Rivero JLL, Taylor CT, Katz LM, Hill EW; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiological Genomics, 40 (2):83-93. Available Online [DOI] [Details]
Hill EW, McGivney BA, Gu J, Whiston R, MacHugh DE; (2010) 'A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses'. BMC Genomics, 11 (1):552-null. Available Online [DOI] [Details]
McGivney, B.A., McGettigan, P.A., Browne, J.A., Evans, A.C., Fonseca, R.G., Loftus, B.J., Lohan, A., MacHugh, D.E., Murphy, B.A., Katz, L. M., Hill, E.W.; (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 (null):398398-null. Available Online [DOI] [Details]
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, Ducro B, Van Arendonk JAM, MacHugh DE, Ennis S, Hill EW, Brama PAJ ; (2010) 'Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses'. Animal Genetics, 41 (suppl. 2):2-7. Available Online [DOI] [Details]
Fonseca, R.G., Kenny, D., Hill, E.W., Katz, L.M.; (2010) 'The association of various speed indices to training responses in Thoroughbred flat racehorses measured with a global positioning and heart rate monitoring system'. Equine Veterinary Journal Supplement, 42 (38):51-57. Available Online [DOI] [Details]
Hill, E.W., Eivers, S.S., McGivney, RG., Fonseca, GU. J., Smith, N.A., Browne, J.A., MacHugh, D.E., Katz, L.M.; (2010) 'Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle'. Equine Veterinary Journal Supplement, 42 (38):576-581. Available Online [DOI] [Details]
Martin, A.M., Elliott, J.A., Duffy, P., Blake, C., Attia, S.B., Browne, J.A., Katz, L.M., Gath, V., McGivney, B.A., Hill, E.W., Murphy, B.A. ; (2010) 'Circadian regulation of locomotor activity and skeletal muscle gene expression in the horse'. Journal of Applied Physiology, 109 (5):1328-1336. Available Online [DOI] [Details]
Bower MA, Whitten M, Nisbet RER, Spencer M, Dominy KM, Murphy AM, Cassidy R, Barrett E, Hill EW, Binns M.; (2010) 'Thoroughbred horse mitochondrial DNA demonstrates closer than expected links between maternal genetic history and pedigree records'. Equine Veterinary Journal, . [Details]
Gu J, MacHugh DE, McGivney BA, Park SDE, Katz LM, Hill EW; (2010) 'Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses'. Equine Veterinary Journal Supplement, 42 (38):569-575. Available Online [DOI] [Details]
Hill, E.W., Gu, J., McGivney, B.A., MacHugh, D.E.; (2010) 'Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance'. Animal Genetics, 41 (Suppl 2):56-63. Available Online [DOI] [Details]
Hill EW; (2010) 'Editorial, Livestock issue'. Briefings in Functional Genomics, 9 (3):191-192. [Details]
O'Gorman GM, Park SD, Hill EW, Meade KG, Coussens PM, Agaba M, Naessens J, Kemp SJ, Machugh DE; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. BMC Genomics, . [Details]
Gu J, Orr N, Park SD, Katz LM, Sulimova G, MacHugh DE, Hill EW; (2009) 'A genome scan for positive selection in thoroughbred horses'. PLoS ONE, 4 (6). Available Online [DOI] [Details]
McGivney BA, Eivers SS, MacHugh DE, MacLeod JN, O'Gorman GM, Park SD, Katz LM, Hill EW; (2009) 'Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy'. BMC Genomics, 10 :638. Available Online [DOI] [Details]
Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MC, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, Nergadze SG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE, Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Lander ES, Lindblad-Toh K.; (2009) 'Genome sequence, comparative analysis, and population genetics of the domestic horse'. Science, 326 (5954):865-867. [Details]
Meade KG, O'Gorman GM, Hill EW, Narciandi F, Agaba M, Kemp SJ, O'Farrelly C, Machugh DE.; (2009) 'Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle'. Molecular immunology, . [Details]
McGahern AM, Edwards CJ, Bower MA, Heffernan A, Park SD, Brophy PO, Bradley DG, MacHugh DE, Hill EW; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Animal Genetics, 37 (5):498-502. [DOI] [Details]
McGahern A, Bower MA, Edwards CJ, Brophy PO, Sulimova G, Zakharov I, Vizuete-Forster M, Levine M, Li S, MacHugh DE, Hill EW; (2006) 'Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations'. Animal Genetics, 37 (5):494-497. [DOI] [Details]
O'Gorman GM, Park SD, Hill EW, Meade KG, Mitchell LC, Agaba M, Gibson JP, Hanotte O, Naessens J, Kemp SJ, MacHugh DE; (2006) 'Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense'. Genomics, 28 (1):53-61. [DOI] [Details]
Tozaki T, Sato F, Hill EW, Miyake T, Endo Y, Kakoi H, Gawahara H, Hirota K, Nakano Y, Nanbo Y, Kurosawa M; (2011) 'Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses'. The Open Veterinary Science Journal, null (Aug11):null-null. Available Online [DOI] [Details]
Hill EW, O'Gorman GM, Agaba M, Gibson JP, Hanotte O, Kemp SJ, Naessens J, Coussens PM, MacHugh DE; (2005) 'Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics'. Veterinary Immunology and Immunopathology, 105 (3-4):247-258. [DOI] [Details]
Eivers, S.S., McGivney, B.A., Gu J., MacHugh, D.E., Katz, L.M., Hill, E.W.; (2011) 'PGC-1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise'. Animal Genetics, . Available Online [DOI] [Details]
Meade KG, Hill EW, Buckley F, MacHugh DE ; (2005) 'Convenient detection of single nucleotide polymorphism haplotypes in the bovine growth hormone gene using amplification-created restriction sites'. Animal Genetics, 36 (2):175-177. [DOI] [Details]
Tozaki T, Hill EW, Hirota K, Kakoi H, Gawahara H, Miyake T, Sugita S, Hasegawa T, Ishida N, Nakano Y, Kurosawa M. ; (2011) 'A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18'. Animal Genetics, null (null):null-null. Available Online [DOI] [Details]
Hanotte O, Bradley DG, Ochieng JW, Verjee Y, Hill EW, Rege JE.; (2002) 'African pastoralism: genetic imprints of origins and migrations'. Science, 296 (5566):336-339. [Details]
Hill EW, Fonseca RG, McGivney BA, Gu J, MacHugh DE, Katz LM. ; (2012) 'MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses'. Journal of Applied Physiology, 112 (null):86-90. Available Online [DOI] [Details]
13. Bower M, Campana M, Whitten C, Edwards C, Jones H, Barrett E, Cassidy R, Nisbet RE, Hill EW, Howe C, Binns M.; (2010) 'The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish Native mares'. Biology Letters, Oct 6 (null):null-null. Available Online [DOI] [Details]
Hill E.W., Al Barody M., Bradley D.G., Ertugrul O., Splan R.K., Zakharov I. & Cunningham E.P.; (2002) 'History and integrity of thoroughbred dam lines revealed in equine mtDNA variation'. ANIMAL GENETICS, 33 :287-294. [Details]
Rosser Z.H., ['] Hill E.W., ['] & Jobling M.A.; (2002) 'Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1526-1543. [Details]
Richards M., ['] Hill E. W., ., ['] & Stefanescu G.; (2000) 'Tracing European founder lineages in the Near Eastern mtDNA pool'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1251-1276. [Details]
Helgason A., ., ['], Hill E.W., ., ['] & Stefansson K.; (2000) 'Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :697-717. [Details]
Hill E.W., Jobling, M.A. & Bradley, DG; (2000) 'Y chromosomes and Irish origins'. NATURE, 404 :351-352. [Details]
Achukwi M.D., Tanya, V.N., Hill, E.W., Bradley, D.G., Meghen, C., Sauveroche, B., Banser, J.T. & Ndoke, J.N.; (1997) 'Susceptibility of the Namchi and Kapsiki cattle of Cameroon to trypanosome infection'. TROPICAL ANIMAL HEALTH AND PRODUCTION, 29 :219-226. [Details]
 

Conference Publications

Hill, E. W., Oâ¿¿Gorman, G. M., Gormley, E., Fitzsimons, T., Rosa, G J.M., Coussens, P. M., MacHugh, D. E. (2003) Functional genomics analysis of the bovine immune response to Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei) Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
MacHugh, D. E., Meade, K.G., O'Gorman, G. M., Gormley, E., Rosa, G J.M., Coussens, P. M., Hill, E. W. (2003) Using gene expression technologies to analyse the bovine immune response to pathogens and parasitesUsing gene expression technologies to analyse the bovine immune response to pathogens and parasites Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
MacHugh, D. E., Meade, K.G., O'Gorman, G. M., Gormley, E., Rosa, G J.M., Coussens, P. M., Hill, E. W. (2003) Using gene expression technologies to analyse the bovine immune response to pathogens and parasites. Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
Hill, E. W., Oâ¿¿Gorman, G. M., Gormley, E., Fitzsimons, T., Rosa, G J.M., Coussens, P. M., MacHugh, D. E. (2003) Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei).. Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
Hill, E.W., O'Gorman, G.M., Gormley, E., Fitzpatrick, T., Rosa, G J.M., Coussens P.M., MacHugh, D.E. (2003) Functional genomics analysis of the bovine immune response to Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei) Proceedings of the International Symposium on Animal Functional Genomics Michigan State University, USA, [Details]
Hill, E.W., O'Gorman, G.M., Gormley, E., Fitzpatrick, T., Rosa, G J.M., Coussens P.M., MacHugh, D.E. (2003) Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei). Proceedings of the International Symposium on Animal Functional Genomics Michigan State University, USA, [Details]
Hill, E. W., O'Gorman, G. M., Agaba, M., Gibson, J. P., Hanotte, O., Kemp, S. J., Naessens, J., Coussens, P. M., MacHugh, D. E. (2004) Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics.. Proceedings of: 1st International Conference on Basic and Clinical Immunogenomics Budapest, Hungary, [Details]
Hill, E. W., O'Gorman, G. M., Agaba, M., Gibson, J. P., Hanotte, O., Kemp, S. J., Naessens, J., Coussens, P. M., MacHugh, D. E. (2004) Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics.Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics Proceedings of: 1st International Conference on Basic and Clinical Immunogenomics Budapest, Hungary, [Details]
McGahern, A., Hill, E.W., MacHugh, D.E., Brophy, P. O. (2005) A molecular genetic characterisation of the endangered Irish Draught horse. Proceedings of the Agricultural Research Forum Tullamore, Co. Offaly, Ireland, , pp.9 [Details]
McGahern, A., Hill, E.W., MacHugh, D.E., Brophy, P. O. (2005) A molecular genetic characterisation of the endangered Irish Draught horseA molecular genetic characterisation of the endangered Irish Draught horse Proceedings of the Agricultural Research Forum Tullamore, Co. Offaly, Ireland, , pp.9 [Details]
O'Gorman, GM,Park, SDE,Hill, EW,Meade, KG,Mitchell, LC,Agaba, M,Gibson, JP,Hanotte, O,Naessens, J,Kemp, SJ,MacHugh, DE (2006) Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense PHYSIOLOGICAL GENOMICS , pp.53-61 [DOI] [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., MacHugh, D. E. (2006) A functional genomics study of trypanotolerant and trypanosusceptible African cattle during A functional genomics study of trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense Infection Proceedings of: 2nd International Symposium on Animal Functional Genomics (ISAFG) Michigan State University, USA, [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., MacHugh, D. E. (2006) A functional genomics study of trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense Infection.. Proceedings of: 2nd International Symposium on Animal Functional Genomics (ISAFG) Michigan State University, USA, [Details]
Hill EW, SS Eivers, BA McGivney, DE MacHugh, C Taylor, K Mason, J MacLeod, LM Katz (2008) Exercise-induced gene expression in equine skeletal muscle 3rd International Symposium on Animal Functional Genomics (ISAFG) [Details]
Eivers, S., McGivney, B., MacHugh, D. E., Taylor, C. T., Mason, K., MacLeod, J., Katz, L. M., Hill, E. W. (2008) Exercise-induced gene expression in equine skeletal muscleExercise-induced gene expression in equine skeletal muscle Proceedings of: International Society for Animal Genetics Conference (ISAG 2008) Amsterdam,The Netherlands, [Details]
Gu, J., MacHugh, D. E., Hill, E. W. (2008) A whole genome scan for regions of positive selection in thoroughbred racehorsesA whole genome scan for regions of positive selection in thoroughbred racehorses Proceedings of: 3rd International Symposium on Animal Functional Genomics (ISAFG) Edinburgh International Conference Centre, Edinburgh, UK, [Details]
O'Gorman, G. M., Park, Stephen D. E., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, David E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infectionTranscriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection Proceedings of Plant and Animal Genome XVI Town and Country Hotel, San Diego, USA, [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, D. E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection.. Proceedings of: Plant and Animal Genome XVII Conference Town & Country Convention Center, San Diego, California, USA, [Details]
O'Gorman, G. M., Park, Stephen D. E., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, David E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection. Proceedings of Plant and Animal Genome XVI Town and Country Hotel, San Diego, USA, [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, D. E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection Proceedings of: Plant and Animal Genome XVII Conference Town & Country Convention Center, San Diego, California, USA, [Details]
McGivney, B., Eivers, S. S., Katz, L. M., MacLeod, J., MacHugh, D. E., O'Gorman, G. M., Park, S. D., Hill, E. W. (2008) Transcriptional profiling of thoroughbred skeletal muscle response to exercise using an equine cDNA microarrayTranscriptional profiling of thoroughbred skeletal muscle response to exercise using an equine cDNA microarray Proceedings of: 3rd International Symposium on Animal Functional Genomics (ISAFG) Edinburgh International Conference Centre, Edinburgh, UK, [Details]
McGivney, B. A., McGettigan, P., Browne, J. A., Fonseca, R. G., Eivers, S. S., Evans, A. C., Loftus, B. J., Lohan, A., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Digital gene expression profiling in Thoroughbred horse skeletal muscle following exercise trainingDigital gene expression profiling in Thoroughbred horse skeletal muscle following exercise training Proceedings of The Physiological Society Meeting University College Dublin, Dublin, Ireland, [Details]
Eivers, S. S., Gu, J., McGivney, B. A., Fonseca, R. G., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Targets of selection in the Thoroughbred horse (Equus caballus) genome contain genes expressed in skeletal muscle following exercise Proceedings of 14th International Biochemistry of Exercise Conference University of Guelph, Ontario, Canada, [Details]
Meade, K. G., Oâ¿¿Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle. Proceedings of the Irish Society for Immunology Annual General Meeting Institute of Molecular Medicine, St. James Hospital, Dublin, Ireland, [Details]
Meade, K. G., Oâ¿¿Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattleDivergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle Proceedings of the Irish Society for Immunology Annual General Meeting Institute of Molecular Medicine, St. James Hospital, Dublin, Ireland, [Details]
McGivney, B. A., McGettigan, P., Browne, J. A., Fonseca, R. G., Eivers, S. S., Evans, A. C., Loftus, B. J., Lohan, A., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Digital gene expression profiling in Thoroughbred horse skeletal muscle following exercise training. Proceedings of The Physiological Society Meeting University College Dublin, Dublin, Ireland, [Details]
Meade, K. G., O'Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle ISI Annual Meeting 2009 Institute of Molecular Medicine, St James Hospital, Dublin 8, Ireland, [Details]
Meade, K. G., O'Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle. ISI Annual Meeting 2009 Institute of Molecular Medicine, St James Hospital, Dublin 8, Ireland, [Details]
Gu J, MacHugh DE, Park SDE, Katz LM, Hill EW; (2010) Sequence variants in equine CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes are associated with elite racing performance in Thoroughbred horses 8th International Conference on Equine Exercise Physiology [Details]
Hill EW, Eivers SS, McGivney BA, Fonseca RG, Gu J, Smith N, Browne J, MacHugh DE, Katz LM; (2010) Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle 8th International Conference on Equine Exercise Physiology [Details]
Hill, E. W., Gu, J., Eivers, S. S., Fonseca, R. G., McGivney, B. A., Govindarajan, P., Orr, N., Katz, L. M., MacHugh, D. E. (2010) A sequence polymorphism in the MSTN gene predicts sprinting ability and racing stamina in Thoroughbred horses Proceedings of the Annual General Meeting of the Irish Thoroughbred Breeder's Association Kill, Ireland, [Details]
Hill, E. W., Gu, J., Eivers, S. S., Fonseca, R. G., McGivney, B. A., Govindarajan, P., Orr, N., Katz, L. M., MacHugh, D. E. (2010) A sequence polymorphism in the MSTN gene predicts sprinting ability and racing stamina in Thoroughbred horses. Proceedings of the Annual General Meeting of the Irish Thoroughbred Breeder's Association Kill, Ireland, [Details]
Fonseca RG, Kenny DA, McGivney BA, Murphy BA, Hill EW, Katz LM; (2011) The response of plasma myeloperoxidase concentrations to exercise and training in a group of Thoroughbred flat racehorses over a two-year period of time French Equine Veterinary Association (AVEF) [Details]
McGivney, B. A., Whiston, R., Browne, J. A., Fonseca, R. G., Gu, J., Katz, L. M., MacHugh, D. E., Hill, E. W. (2011) Investigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscleInvestigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscle Proceedings of the 4th International Symposium on Animal Functional Genomics (ISAFG) Dublin, Ireland, [Details]
McGivney, B. A., Whiston, R., Browne, J. A., Fonseca, R. G., Gu, J., Katz, L. M., MacHugh, D. E., Hill, E. W. (2011) Investigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscle. Proceedings of the 4th International Symposium on Animal Functional Genomics (ISAFG) Dublin, Ireland, [Details]
Carberry, C., McGivney, B. A., McLoughlin, K., MacHugh, D. E., Hill, E. W. (2013) A genome wide association study to identify SNPs associated with precocity in the Thoroughbred (Flat) racehorse Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
MacHugh, D. E., McGivney, B. A., Killick, K. E., McGettigan, P. A., Gu, J., Carberry, C., Hill, E. W. (2013) A pooled high-throughput sequencing approach to identify novel equine SNPs and associations with elite Thoroughbred racing performance Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
Hill, E. W., McGivney, B. A., Donovan, G., Gough, K., Carberry, C., MacHugh, D. E. (2013) SNP associations with height in the Thoroughbred (Flat) racehorseSNP associations with height in the Thoroughbred (Flat) racehorse Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
McGettigan, P. A., Farries, G., Browne, J. A., McGivney, B. A., Herdan, C., Gough, K., Katz, L. M., MacHugh, D. E., Hill, E. W. (2014) Field study of Thoroughbred racehorse muscle transcriptomic response to exercise pre- and post-training using RNA-seq Proceedings of the EMBL-EBI Livestock Genomics Meeting Homerton College, Cambridge, UK, [Details]
Hill EW, BM McGivney, C Herdan, K Gough, LM Katz (2014) Investigation of MSTN genotype association with VO2peak in untrained yearlings 9th International Conference on Equine Exercise Physiology [Details]
Hill, E. W., McGettigan, P. A., Parnell, A. C., Ryan, D., MacHugh, D. E. (2015) Development of genomic prediction methods for elite racing performance in Thoroughbred racehorses 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
McGettigan, P. A., Farries, G., Browne, J. A., McGivney, B. A., Herdan, C., Gough, K., Katz, L. M., MacHugh, D. E., Hill, E. W. (2015) Field Study of Thoroughbred racehorse skeletal muscle gene expression response to exercise pre- and post-training using RNA-seq 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
Rue-Albrecht, K., McGettigan, P. A., Hernandez, B., Parnell, A. C., Gordon, S. V., Hill, E. W., MacHugh, D. E. (2015) GOexpress: analysis and visualisation of gene expression data using gene ontology annotations 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
   

Editorial

Meade, KG,Hill, EW,Buckley, F,MacHugh, DE; (2005) Convenient detection of single nucleotide polymorphism haplotypes in the bovine growth hormone gene using amplification-created restriction sites. Editorial [DOI] [Details]
Hill, EW; (2010) Livestock Issue. Editorial [DOI] [Details]
                           

Reviews

McGivney, BA,Eivers, SS,MacHugh, DE,MacLeod, JN,O'Gorman, GM,De Park, S,Katz, LM,Hill, EW (2009) Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy. Reviews [DOI] [Details]
                                                                             

Research

Research Interests

The aim of the research programme is to perform extensive and intensive phenotyping of end-point exercise physiological performance parameters and endophenotypes associated with muscular and mitochondrial function to test the hypothesis that genetic variation, catalogued using state-of-the-art genomic technologies, contributes to functional micro-adaptations that are influenced by exercise and cumulatively increase aerobic capacity.

Genetic variation is being assessed in a large cohort of Thoroughbred horses in training:

·         Illumina Equine SNP70 genotyping array

·         Affymetrix Equine SNP670 genotyping array
 

To project will test the hypotheses that genetic variation:

1)      contributes to variation in measured end-point physiological exercise parameters

2)      is reflected in variation in skeletal muscle gene expression

3)      underpins complex pathological phenotypes leading to poor-performance

4)      influences variation in mitochondrial function

Additional projects:
Genetic variation among indigenous Chinese horse populations

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Genomics of performance in thoroughbred horses
Start Date / End Date : 01-OCT-04 / 31-MAR-10
Sponsor : Jim Bolger (JS Bolger)
Title : A genome-wide association study for Thoroughbred athletic performance using the EquineSNP50 Chip
Start Date / End Date : 01-DEC-08 / 31-DEC-10
Sponsor : University College Dublin (UCD)
Title : International Conference on Equine Exercise Physiology
Start Date / End Date : 03-AUG-09 / 31-JAN-11
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : An evaluation of dosage profiling and genomic analysis to predict the optimum racing distance for Thoroughbred horses and determination of the ancestral origin of the "speed" allele
Start Date / End Date : 01-DEC-10 / 30-NOV-11
Sponsor : University College Dublin (UCD)
Title : Influence of Genomic Class Test in Predicting Yearling Sale Price and Total Career Earnings of Racehorses
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Science Foundation Ireland (SFI)
Title : Integrated genomics approaches to understanding genetic contributions to system-wide exercise physiology parameters in a large animal model.
Start Date / End Date : 01-APR-12 / 01-APR-17
Sponsor : Science Foundation Ireland (SFI)
Title : A promotional film illustrating world-class science in horse genomics and the impact on the global bloodstock industry
Start Date / End Date : 01-MAY-13 / 31-OCT-13
Sponsor : Equinome Ltd
Title : Using genomic technologies to investigate genetic associations with performance parameters in horses
Start Date / End Date : 01-APR-14 / 24-APR-15
Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19

Recent Postgraduates

Jingjing Gu, PhD 2009
Beatrice McGivney, PhD 2009
Suzanne Eivers, PhD 2009

Current Postgraduate Students

Amy Holtby, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Haige Han, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Charlotte Herdan, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Gabriella Farries, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201600   ANSC30210     Animal Science: Equine Industries
201600   ANSC40090     Animal Science: Equine Science Project
201600   ANSC30250     Animal Science: Equine Genetics