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Researchers at UCD

researcher

Emmeline Hill

Associate Professor

School Of Agriculture & Food Science
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166231
Email: emmeline.hill@ucd.ie

Biography

1991-1995: BA (mod Genetics), Trinity College Dublin
1995-1999: Ph.D., Trinity College Dublin
1998-1999: Research Associate, International Livestock Research Institute, Kenya
1999-2000: Research Consultant, FAO of the United Nations
2000-2001: Postdoctoral Researcher, Trinity College Dublin
2002-2004: Postdoctoral Researcher, University College Dublin
2004-2010: Science Foundation Ireland President of Ireland Young Researcher Award
2009: Co-founder Equinome Ltd
2004: College Lecturer in Equine Science
2012-2017: Science Foundation Ireland Principal Investigator Award
2014: Senior Lecturer in Equine Science
2015: Chief Science Officer Plusvital Ltd
2016: Associate Professor of Equine Science


Professional

Honours and Awards

Year: 2016.
Title: SFI Best Reported Impact Award
Year: 2011.
Title: Business Entrepreneur of the Year Award
Year: 2010.
Title: Entrepreneur of the Year Award
Year: 2009.
Title: Campus Company Development Programme Start-Up Award
Year: 2004.
Title: President of Ireland Young Researcher Award
Year: 2012.
Title: Irish Tatler Entrepreneur of the Year Award
Year: 2014.
Title: UCD Innovation Award

Associations

Association: International Womens Forum, Function/Role: Member

Patents

Patent US9249470 : Method for predicting the athletic performance potential of a subject
Patent NZ591711 : A METHOD FOR PREDICTING ATHLETIC PERFORMANCE POTENTIAL
Patent AU2009290452 : A method for predicting athletic performance potential
Patent US8771943 : Method for predicting athletic performance potential
Patent JP5667057 : A METHOD FOR PREDICTING ATHLETIC PERFORMANCE POTENTIAL¿
Patent EP2352850: : A METHOD FOR PREDICTING ATHLETIC PERFORMANCE POTENTIAL

Disclosures

Predictive genetic markers for height in Thoroughbred horses. Inventor(s):Hill, Katz, Herdan, Submitted: 01-DEC-15
A major risk locus and other predictive genetic markers for Recurrent Laryngeal Neuropathy in Thoroughbred horses.. Inventor(s):Hill, Katz, Herdan, Submitted: 01-DEC-15
A genotype-specific nutraceutical for horses.. Inventor(s):Hill, Katz, Rooney, Porter, Submitted: 31-AUG-15

Licensing

Supplementation of specific horse genotypes with a co-enzyme. Inventor(s):Hill, Katz, Porter, Rooney, Licensee:Plusvital Ltd

Conference Contributions

Hill, E.W.,O'Gorman, G.M.,Gormley, E.,Fitzpatrick, T.,Rosa, G J.M.,Coussens P.M.,MacHugh, D.E.; (2003) Proceedings of the International Symposium on Animal Functional Genomics. [Published Abstract], Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei), Michigan State University, USA .
Emmeline Hill; (2005) British Association Festival of Science 2005. [Invited Oral Presentation], British Association Festival of Science 2005, Dublin , 03-SEP-05 - 10-SEP-05.
Emmeline Hill; (2005) British Equine Veterinary Association Congress 2005. [Invited Oral Presentation], British Equine Veterinary Association Congress 2005, Harrogate, UK , 14-SEP-05 - 17-SEP-05.
Emmeline Hill; (2006) Horse Genetic Diversity - What we know and what we'd like to know. [Invited Oral Presentation], International Horse Genome Project Planning Workshop, The Broad Institute, MIT, Boston , 27-APR-06 - 27-APR-06.
Hill EW, SS Eivers, BA McGivney, RG Fonseca, J Gu, N Smith, J Browne, DE MacHugh, LM Katz; (2010) Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle. [Published Abstract], 8th International Conference on Equine Exercise Physiology, South Africa , 03-SEP-10 - 06-SEP-10.
McGettigan, PA; Farries, G; Browne, JA; McGivney, BA; Herdasn, C; Gough, K; Katz, LM; MacHugh, DE; Hill, EW (2014) Field study of Thoroughbred racehorse muscle transcriptomic response to exercise pre- and post-training using RNA-seq. [Oral Presentation], EMBL-EBI Livestock Genomics Meeting, Homerton College, Cambridge, UK , 18-SEP-14 - 20-SEP-14.
Hill EW, BM McGivney, C Herdan, K Gough, LM Katz (2014) Investigation of MSTN genotype association with VO2peak in untrained yearlings. [Oral Presentation], 9th International Conference on Equine Exercise Physiology, Chester, UK , 16-JUN-14 - 20-JUN-14.
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training progression in Thoroughbred racehorses. [Oral Presentation], Computational Biology and Innovation Symposium, Dublin, Ireland , 03-DEC-15 - 04-DEC-15.
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training progression in Thorougbred racehorses. [Poster Presentation (Refereed)], 6th International Symposium on Animal Funcitonal Genomics (ISAFG) conference, Piacenza, Italy , 27-JUL-15 - 29-JUL-15.
McGettigan, PA; Farries, G; Browne, JA; McGivney, BA; Herdan, C; Gough, K; Katz, LM; MacHugh, DE; Hill, EW (2015) Field study of Thorougbred racehorse muscle transcriptomic response to exercise pre- and post-training using RNA-seq. [Poster Presentation], Proceedings of the 11th Dorothy Russell Havemyer Foundation- International Equine Genome Mapping Workshop, Hannover, Germany , 22-JUL-15 - 25-JUL-15.
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thoroughbred racehorses. [Oral Presentation], Australasian Equine Science Symposium, Queensland, Australia , 08-JUN-16 - 10-JUN-16.
Herdan, C; Sweeney, J; Gough, KF; Hill, EW; Katz, LM (2016) Intra-horse variation on overground endoscopy. [Oral Presentation], 2016 ACVS Surgery Summit Veterinary Symposium, Seattle, WA, USA , 06-OCT-16 - 08-OCT-16.
Rooney, MF; Hill, EW; Katz, LM; Porter, RK (2016) MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre coposition in untrained Thoroughbred horses. [Poster Presentation (Refereed)], 19th European Bioenergetics Conference, Riva del Garda, Italy , 02-JUL-16 - 07-JUL-16.
Farries, G; McGettigan, PA; Gough, KF; Mcgiveny, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thoroughbred racehorses. [Oral Presentation], Conway Festival of Research and Innovation, Dublin, Ireland , 13-SEP-16 - 15-SEP-16.
Hill, EW; McGivney, BA; Wiencko, HL; Parnell, AC; Farries, G; Bryan, K; Katz, LM; MacHugh, DE (2017) [Poster Presentation], CELL Symposia: Exercise Metabolism, Gothenburg, Sweden , 21-MAY-17 - 23-MAY-17.
Farries, G; McGivney, BA; Gough, KF; Katz, LM; Hill, EW (2017) Genetic contributions to measured speed variables in Thoroughbred racehorses during earling training. [Oral Presentation], International Society of Animal Genomics, Dublin, Ireland , 17-JUL-17 - 21-JUL-17.
Bryan, K; McGivney, BA; Farries, G; Gough, KF; MacHugh, DE; Katz, LM Hill, EW (2017) Evidence for a transcriptome-driven variant-specific functional effect of the equine myostatin (MSTN) performance SNP (g.66493737C>T). [Poster Presentation], CELL Symposia: Exercise Metabolism, Gothenburg, Sweden , 21-MAY-17 - 23-MAY-17.
Farries, G; McGivney, BA; Gough, KF; Katz, LM; Hill, EW (2017) Genetic contributions to measured speed variables in Thoroughbred racehorses during early training. [Poster Presentation], CELL Symposia: Exercise Metabolism, Gothenburg, Sweden , 21-MAY-17 - 23-MAY-17.
McGivney, C; Katz, LM; Hill, EW (2017) Identification of genetic risk loci for recurrent laryngeal neuropathy in the Thoroughbred horse. [Invited Oral Presentation], World Equine Airway Symposium, Copenhagen, Denmark , 13-JUL-17 - 15-JUL-17.

Committees

Committee : Warmblood Association of Ireland
Committee : Plusvital Board Member
Committee : Royal Agricultural University Centre for Equine Management and Science, Advisory Council Board member
Committee : University Research Strategy Board (URSB) Sub-Committee: Researcher Advisory Group
Committee : Board of Assessors
Committee : Board of Assessors
Committee : Timetable Committee
Committee : Curriculum Committee
Committee : Mature Student Assessment Committee

Employment

Employer: University College Dublin
Position: Postodctoral Researcher
Employer: UN Food and Agriculture Organization
Position: Consultant
Employer: Trinity College Dublin
Position: Postdoctoral Researcher

Education

Year 1995 Institution:
Qualification: BA Subject:
Year 1999 Institution:
Qualification: PhD Subject:
 

Consultancy

Client: Plusvital Ltd
Client: Equinome Ltd

Outreach Activities

Bloodline: The Search for Speed

In 2011 I met with UK Producer/Director Harvey Jones to conceive and develop a short film documentary highlighting my research. In collaboration with SFI and UCD Research Public Engagement and Outreach manager we produced Bloodline: The Search for Speed, 2013.

To view see: https://www.youtube.com/watch?v=LnXzuHAxwUY

EQUUS - Bloodline led to meeting with internationally acclaimed award winning Canadian documentary film Producer/Director Niobe Thompson for the development of a feature sequence on the ¿Speed Gene¿ in the CBC Canada three part documentary series, EQUUS. I am one of three international equine genomics scientists featured (also Prof M McCue and Prof L Orlando). CBC filmed on location in Ireland for 4 days in 2017. EQUUS will be part of CBC¿s science and nature program The Nature of Things. Material generated for Bloodline will be used in EQUUS and UCD and SFI will be credited for the contribution. First release Canada, 2018, followed by PBS (USA), ARTE (France) and expected BBC/RTE screening 2019.
Royal Irish Academy Public Discourse on ¿The Speed Gene¿, 2013.
Humanist Association of Ireland Darwin Day Lecture, 2017
  • Irish Thoroughbred Breeders¿ Association Expo, 2018

            
  • HorseTech Conference, UK, 2017

                      
  • Commercial Breeders¿ Association, USA, 2017

  • Newmarket Equine Medicine Discussion Group, UK, 2016

                      
  • Breeding for Gold conference, UK, 2016

                      
  • Plusvital Roadshow, UK, 2016

                      
  • Summerhill Stud Winter Workshop, South Africa, 2015

                      
  • International Thoroughbred Breeders¿ Federation (ITBF) Veterinary Forum, 2015

                      
  • Thoroughbred Breeders¿ Association meeting, UK, 2015

                      
  • Cape Thoroughbred Breeders Association conference, South Africa, 2014

                      
 
  • Irish Equine Veterinary Conference, 2014

  • Horse Sport Ireland National Coaching and Breeding conference, 2014

                      
  • Natal Breeders Association meeting, South Africa, 2013

                      
  • International Federation of Horse Racing Authorities and ITBF meeting, France, 2012

                      
  • Amgen Biotech Experience training course for Secondary School  teachers, workshop, 2016

                      
  • Consulted with Science Learning & Participation Officer of the National Heritage Centre for Horseracing and Sporting Art, Newmarket, UK and contributed to (1) Genetics Display (2016) and (2) DNA bracelet activity using the ¿Speed Gene¿ (2017).

                      
  • Zoological Society, TCD, 2016, 2017

  • School of Business, DCU, 2016

                      
  • University of Tennessee, UCD student visit, 2014, 2016

                      
  • Royal Agricultural University, UK, UCD student visit, 2014

                      
  • Department of Biochemistry, NUIG, 2013

                      
  • Purdue University, USA, UCD student visits, 2013, 2014, 2016

                      
  • Irish National Stud, Bloodstock training course, 2012 - 2017

                      
                      
  • BSAS Conference, student day ¿Careers Path¿, invited speaker, 2018

  • Dublin Horse Show, RDS, Ring 2, interview, 2017

                      
  • Queens University WeCAN Women¿s early Career Academic Network, External Careers Pathway Seminar, speaker, 2015

                      
  • Going For Growth, ambassador, 2014

                      
  • Irish Tatler Business Academy, panel, 2013

                      
                      
  • Equus Live, interview, 2013

Journals Edited

Journal Of Heredity: Reviewer.
Veterinary Journal: Reviewer.
Molecular Ecology: Reviewer.
Journal Of Animal Breeding And Genetics: Reviewer.
Genetical Research: Reviewer.
Equine Veterinary Journal: Reviewer.
European Journal Of Applied Physiology: Reviewer.
Bmc Genomics: Reviewer.
Nature Genetics: Reviewer.
: Reviewer.
Animal Genetics: Reviewer.
Nature: Reviewer.
Plos One: Reviewer.
Briefings In Functional Genomics: Editorial Board member.
 

Publications

 

Book Chapters

Emmeline W. Hill, Bart J. Ducro, P. René van Weeren, Albert Barneveld, Willem Back (2013) 'Genetic contributions to exercise and athletic performance' In: Back and Clayton (eds). Equine Locomotion. USA: Saunders Ltd / Elsevier. [Details]
Hill EW, Katz LM, MacHugh DE; (2013) 'Genomics of Performance' In: Chowdhary B (eds). Equine Genomics. Hoboken, NJ: Wiley-Blackwell. , pp.265-284 [Details]
 

Peer Reviewed Journals

Gu, J., MacHugh, D. E., McGivney, B. A., Park, S. D. E., Katz, L. M., Hill, E. W. (2010) 'Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses'. Equine Veterinary Journal, 42 :569-575. Available Online [Details]
Katz, LM; McGivney, BM; Fonseca, R; Hill, EW (2014) 'Candidate gene SNP associations with fat-free mass (FFM) measurements in horses in training'. Equine Veterinary Journal, 46 :35. [DOI] [Details]
McGivney, BM; Herdan, C; Gough, K; Katz, LM; Hill, EW (2014) 'Effect of training on PPARGC1A and FNDC5 gene expression in Thoroughbred horses'. Equine Veterinary Journal, 46 :35. [DOI] [Details]
Herdan, C; McGivney, BM; Gough, K; Hill, EW; Katz, LM (2014) 'A single nucleotide polymorphism (BIEC2-808543) on ECA3 is associated with recurrent laryngeal neuropathy independent of height in Thoroughbred horses'. Equine Veterinary Journal, 46 :34. [DOI] [Details]
Katz, LM; Gough, K; Herdan, C; McGivney, BM; Bayly, WM; Sides, R; Hill, EW (2014) 'Evaluation of a portable system designed to measure ventilatory parameters and oxygen consumption in unridden horses'. Equine Veterinary Journal, 46 :23. [DOI] [Details]
Hill, EW; McGivney BM; Herdan, C; Gough, K; Katz, LM (2014) 'Investigation of MSTN genotpe association with VO2peak in untrained yearlings'. Equine Veterinary Journal, 46 :35. [DOI] [Details]
Katz, LM; Mooney, LA; Gough, K; McGivney, CL; McCoughlan, M; Hill, EW; Anhold, H (2016) 'Evaluation of a portable analyzer for measuring hemoglobin concentrations and oxygen saturation in whole-blood samples from domestic animals'. Journal of Equine Veterinary Science, 45 :64-72. [DOI] [Details]
McGivney, CL; Sweeney, J; David, F; O'Leary, JM; Hill, EW; Katz, LM (2016) 'Intra- and inter-observer reliability estimates for identification and grading of upper respiratory tract abnormalities recorded in horses at rest and during overground endoscopy'. Equine Veterinary Journal, 49 :433-437. [DOI] [Details]
McGivney, BA; Griffin, M; Gough, KF; McGivney, CL; Browne, JA; Hill, EW; Katz, LM (2017) 'Evaluation of microRNA expression in plasma and skeletal muscle of Thoroughbred horses in training'. BMC Veterinary Research, 13 (1):347. [DOI] [Details]
McGivney, CL; Sweeney, J; Gough, KF; Hill, EW; Katz, LM (2017) 'Evaluation of repeatability of overground endoscopic examination results in young Thoroughbreds with no treatment intervention'. Equine Veterinary Journal, . [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2017) 'Genetic contributions to precocity traits in racing Thoroughbreds'. Animal Genetics, . [Details]
Bryan K., McGivney B.A., Farries G. McGettigan P.A.. McGivney C.L., Gough K.F., MacHugh D.E., Katz L.M., Hill E.W. (2017) 'Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components'. BMC Genomics, 18 (1). [DOI] [Details]
Rooney, MF; Porter, RK; Katz, LM; Hill, EW (2017) 'Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse'. PLoS ONE, 12 (11):e0186247. [DOI] [Details]
Hill, EW; McGivney, BA; Wiencko, HL; McGovern, S; Weiser, M; Parnell, AC; Katz, LM; MacHugh, DE (2017) 'Identification of predictive genetic markers for racing durability indicate genes that may be relevant for termperament in the Thoroughbred'. PLoS ONE, . [Details]
McGivney, CL; Sweeney, J; Gough, KF; Hill, EW; Katz, LM (2017) 'Impact of pharyngeal endoscopic tip placement and water flushing interval on upper respiratory tract disorders in horses undergoing overground endoscopy'. Equine Veterinary Journal, . [Details]
McGivney, CL; Gough, KF; McGivney, BA; Farries, G; Hill, EW; Katz, LM (2017) 'Factor analysis of conformational measurements in thoroughbred horses with and without recurrent laryngeal neuropathy'. Equine Veterinary Journal, . [Details]
Katz, LM; Gough, KF; McGivney, CL; Anhold, H; Hill, EW (2017) 'Effect of submaximal and high-intensity training on venous haemoglobin concentrations in Thoroughbred racehorses'. Journal of Equine Veterinary Science, 55 :34-39. [DOI] [Details]
Meade, K. G., Hill, E. W., Buckley, F., MacHugh, D. E. (2005) 'Convenient detection of single nucleotide polymorphism haplotypes in the bovine growth hormone gene using amplification-created restriction sites'. Animal Genetics, 36 (2):175-177. Available Online [Details]
Hill, EW,O'Gorman, GM,Agaba, M,Gibson, JP,Hanotte, O,Kemp, SJ,Naessens, J,Coussens, PM,MacHugh, DE; (2005) 'Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics'. Veterinary Immunology and Immunopathology, 105 :247-258. [DOI] [Details]
McGahern, A., Bower, M.A., Edwards, C.J., Brophy, P.O., Sulimova, G., Zakharov, I., Vizuete-Forster, M., Levine, M., Li, S., Machugh, D.E., Hill, E.W.; (2006) 'Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations'. Animal Genetics, 37 (5):494-7. [Details]
O'Gorman, GM; Park, SDE; Hill, EW; Meade, KG; Mitchell, LC; Agaba, M; Gibson, JP; Hanotte, O; Naessens, J; Kemp, SJ; MacHugh, DE; ; (2006) 'Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense'. Physiological Genomics, 28 (1):53-61. [Details]
O¿Gorman, G.M., Park, S.D.E. Hill, E.W. Meade, K.G. Coussens, P.M. Agaba, M., Naessens, J., Kemp, S.J., MacHugh, D.E.; (2008) 'Gene expression changes in peripheral blood mononuclear cells (PBMC) from African cattle infected with Trypanosoma congolense0 revealed by transcriptional profiling'. BMC Genomics, (in press) . [Details]
McGivney, B. A.,Eivers, S. S.,MacHugh, D. E.,MacLeod, J. N.,O'Gorman, G. M.,Park, S. D.,Katz, L. M.,Hill, E. W.; (2009) 'Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy'. BMC Genomics, 10 :638638. Available Online [Details]
Gu, J.,Orr, N.,Park, S. D.,Katz, L. M.,Sulimova, G.,MacHugh, D. E.,Hill, E. W.; (2009) 'A genome scan for positive selection in thoroughbred horses'. PLoS One, 4 (66). Available Online [Details]
O'Gorman, G. M.,Park, S. D.,Hill, E. W.,Meade, K. G.,Coussens, P. M.,Agaba, M.,Naessens, J.,Kemp, S. J.,MacHugh, D. E.; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. BMC Genomics, 10 :207207. Available Online [Details]
Gu, JJ,Orr, N,Park, SD,Katz, LM,Sulimova, G,MacHugh, DE,Hill, EW; (2009) 'A Genome Scan for Positive Selection in Thoroughbred Horses'. PLoS ONE, 4 . [DOI] [Details]
Meade, KG,O'Gorman, GM,Hill, EW,Narciandi, F,Agaba, M,Kemp, SJ,O'Farrelly, C,MacHugh, DE; (2009) 'Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle'. Molecular Immunology, 47 :196-204. [DOI] [Details]
Wade, CM,Giulotto, E,Sigurdsson, S,Zoli, M,Gnerre, S,Imsland, F,Lear, TL,Adelson, DL,Bailey, E,Bellone, RR,Blocker, H,Distl, O,Edgar, RC,Garber, M,Leeb, T,Mauceli, E,MacLeod, JN,Penedo, MCT,Raison, JM,Sharpe, T,Vogel, J,Andersson, L,Antczak, DF,Biagi, T,Binns, MM,Chowdhary, BP,Coleman, SJ,Della Valle, G,Fryc, S,Guerin, G,Hasegawa, T,Hill, EW,Jurka, J,Kiialainen, A,Lindgren, G,Liu, J,Magnani, E,Mickelson, JR,Murray, J,Nergadze, SG,Onofrio, R,Pedroni, S,Piras, MF,Raudsepp, T,Rocchi, M,Roed, KH,Ryder, OA,Searle, S,Skow, L,Swinburne, JE,Syvanen, AC,Tozaki, T,Valberg, SJ,Vaudin, M,White, JR,Zody, MC,Lander, ES,Lindblad-Toh, K,Broad Inst Genome Sequencing Perfo,Broad Inst Whole Genome Assembly T; (2009) 'Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse'. Science AAAS, 326 :865-867. [DOI] [Details]
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, Ducro B, Van Arendonk JA, MacHugh DE, Ennis S, Hill EW, Brama PA (2010) 'Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses'. Gene, 41 Suppl 2 :2-7. [DOI] [Details]
Eivers, S. S.,McGivney, B. A.,Fonseca, R. G.,MacHugh, D. E.,Menson, K.,Park, S. D.,Rivero, J. L.,Taylor, C. T.,Katz, L. M.,Hill, E. W.; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiological genomics, 40 (2):83-93. Available Online [Details]
Eivers, S. S., McGivney, B. A., Fonseca, R. G., MacHugh, D. E., Menson, K., Park, S. D., Rivero, J. L. L., Taylor, C. T., Katz, L. M., Hill, E. W. (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exersise and training (vol 40, pg 83, 2010)'. Physiological Genomics, 41 (2):201-201. Available Online [Details]
Hill, EW,Gu, JJ,Eivers, SS,Fonseca, RG,McGivney, BA,Govindarajan, P,Orr, N,Katz, LM,MacHugh, D; (2010) 'A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses'. PLoS ONE, 5 . [DOI] [Details]
Eivers, SS,McGivney, BA,Fonseca, RG,MacHugh, DE,Menson, K,Park, SD,Rivero, JLL,Taylor, CT,Katz, LM,Hill, EW; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Genomics, 40 :83-93. [DOI] [Details]
McGivney, BA,McGettigan, PA,Browne, JA,Evans, ACO,Fonseca, RG,Loftus, BJ,Lohan, A,MacHugh, DE,Murphy, BA,Katz, LM,Hill, EW; (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 . [DOI] [Details]
Hill, EW,McGivney, BA,Gu, JJ,Whiston, R,MacHugh, DE; (2010) 'A genome-wide SNP-association study confirms a sequence variant (g.66493737C > T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses'. BMC Genomics, 11 . [DOI] [Details]
Gu, J,MacHugh, DE,McGivney, BA,Park, SDE,Katz, LM,Hill, EW; (2010) 'Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses'. Equine Veterinary Journal, 42 :569-575. [DOI] [Details]
Hill, EW,Eivers, SS,McGivney, BA,Fonseca, RG,Gu, J,Smith, NA,Browne, JA,MacHugh, DE,Katz, LM; (2010) 'Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle'. Equine Veterinary Journal, 42 :576-581. [DOI] [Details]
Fonseca, RG,Kenny, DA,Hill, EW,Katz, LM; (2010) 'The association of various speed indices to training responses in Thoroughbred flat racehorses measured with a global positioning and heart rate monitoring system'. Equine Veterinary Journal, 42 :51-57. [DOI] [Details]
Hill, EW,Gu, J,McGivney, BA,MacHugh, DE; (2010) 'Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance'. Animal Genetics, 41 :56-63. [DOI] [Details]
Bower, MA,Campana, MG,Whitten, M,Edwards, CJ,Jones, H,Barrett, E,Cassidy, R,Nisbet, RER,Hill, EW,Howe, CJ,Binns, M; (2011) 'The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish native mares'. Biology Letters, 7 :316-320. [DOI] [Details]
Tozaki, T,Sato, F,Hill, EW,Miyake, T,Endo, Y,Kakoi, H,Gawahara, H,Hirota, K,Nakano, Y,Nambo, Y,Kurosawa, M (2011) 'Sequence Variants at the myostatin Gene Locus Influence the Body Composition of Thoroughbred Horses'. Journal of Veterinary Medical Science, 73 :1617-1624. [Details]
M. A. Bower, B. A. McGivney, M. G. Campana, J. Gu, L. S. Andersson, E. Barrett, C. R. Davis, S. Mikko, F. Stock, V. Voronkova, D. G. Bradley, A. G. Fahey, G. Lindgren, D. E. MacHugh, G. Sulimova and E. W. Hill; (2012) 'The genetic origin and history of speed in the Thoroughbred racehorse'. Nature Communications, 3 :643. Available Online [DOI] [Details]
Hill, E. W., Ryan, D. P., MacHugh, D. E. (2012) 'Horses for Courses: a DNA-based Test for Race Distance Aptitude in Thoroughbred Racehorses'. Recent Patents on DNA and Gene Sequences, 6 (3):203-8. Available Online [Details]
Hill, EW,Fonseca, RG,McGivney, BA,Gu, JJ,MacHugh, DE,Katz, LM (2012) 'MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses'. Journal of Applied Physiology, 112 :86-90. [DOI] [Details]
Tozaki, T,Hill, EW,Hirota, K,Kakoi, H,Gawahara, H,Miyake, T,Sugita, S,Hasegawa, T,Ishida, N,Nakano, Y,Kurosawa, M (2012) 'A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18'. Animal Genetics, 43 :42-52. [DOI] [Details]
Bower, MA,McGivney, BA,Campana, MG,Gu, JJ,Andersson, LS,Barrett, E,Davis, CR,Mikko, S,Stock, F,Voronkova, V,Bradley, DG,Fahey, AG,Lindgren, G,MacHugh, DE,Sulimova, G,Hill, EW (2012) 'The genetic origin and history of speed in the Thoroughbred racehorse'. Nature Communications, 3 . [DOI] [Details]
McCue, ME,Bannasch, DL,Petersen, JL,Gurr, J,Bailey, E,Binns, MM,Distl, O,Guerin, G,Hasegawa, T,Hill, EW,Leeb, T,Lindgren, G,Penedo, MCT,Roed, KH,Ryder, OA,Swinburne, JE,Tozaki, T,Valberg, SJ,Vaudin, M,Lindblad-Toh, K,Wade, CM,Mickelson, JR (2012) 'A High Density SNP Array for the Domestic Horse and Extant Perissodactyla: Utility for Association Mapping, Genetic Diversity, and Phylogeny Studies'. PLoS Genetics, 8 . [DOI] [Details]
Eivers, SS,McGivney, BA,Gu, J,MacHugh, DE,Katz, LM,Hill, EW (2012) 'PGC-1 alpha encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise'. Animal Genetics, 43 :153-162. [DOI] [Details]
Bower, MA,Campana, MG,Nisbet, RER,Weller, R,Whitten, M,Edwards, CJ,Stock, F,Barrett, E,O'Connell, TC,Hill, EW,Wilson, AM,Howe, CJ,Barker, G,Binns, M (2012) 'TRUTH IN THE BONES: RESOLVING THE IDENTITY OF THE FOUNDING ELITE THOROUGHBRED RACEHORSES'. Archaeometry, 54 :916-925. [DOI] [Details]
McGivney, BA,Browne, JA,Fonseca, RG,Katz, LM,MacHugh, DE,Whiston, R,Hill, EW (2012) 'MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance'. Animal Genetics, 43 :810-812. [DOI] [Details]
Moridi, M,Masoudi, AA,Torshizi, RV,Hill, EW (2013) 'Mitochondrial DNA D-loop sequence variation in maternal lineages of Iranian native horses'. Animal Genetics, 44 :209-213. [DOI] [Details]
Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara Machado A, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MC, Piercy RJ, Raekallio M, Rieder S, Røed KH, Silvestrelli M, Swinburne J, Tozaki T, Vaudin M, M Wade C, McCue ME (2013) 'Genetic diversity in the modern horse illustrated from genome-wide SNP data'. PLoS ONE, 8 (1). [DOI] [Details]
Petersen, JL,Mickelson, JR,Rendahl, AK,Valberg, SJ,Andersson, LS,Axelsson, J,Bailey, E,Bannasch, D,Binns, MM,Borges, AS,Brama, P,Machado, AD,Capomaccio, S,Cappelli, K,Cothran, EG,Distl, O,Fox-Clipsham, L,Graves, KT,Guerin, G,Haase, B,Hasegawa, T,Hemmann, K,Hill, EW,Leeb, T,Lindgren, G,Lohi, H,Lopes, MS,McGivney, BA,Mikko, S,Orr, N,Penedo, MCT,Piercy, RJ,Raekallio, M,Rieder, S,Roed, KH,Swinburne, J,Tozaki, T,Vaudin, M,Wade, CM,Mccue, ME (2013) 'Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds'. PLoS Genetics, 9 . [DOI] [Details]
Bower MA, Whitten M, Nisbet RE, Spencer M, Dominy KM, Murphy AM, Cassidy R, Barrett E, Hill EW, Binns M. (2013) 'Thoroughbred racehorse mitochondrial DNA demonstrates closer than expected links between maternal genetic history and pedigree records'. Journal of Animal Breeding and Genetics, 130 (3):227-235. [DOI] [Details]
Fonseca RG, Kenny DA, Hill EW, Katz LM. (2013) 'The relationship between body composition, training and race performance in a group of Thoroughbred flat racehorses'. Equine Veterinary Journal, . [DOI] [Details]
Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., Brama, P. A. (2013) 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10'. Animal Genetics, 44 (4):408-12. [Details]
Lisa M. Katz, Louise A. Mooney, Katie Gough, Charlotte L. McGivney, Maureen McCoughlan, Emmeline W. Hill, Heinrich Anhold (2016) 'Evaluation of a portable analyzer for determining hemoglobin concentrations and oxygen saturation in whole-blood samples from domestic animals'. Journal of Equine Veterinary Science, :64-72. [DOI] [Details]
Rivero JL, Hill EW. (2016) 'Skeletal muscle adaptations and muscle genomics of performance horses'. Veterinary Journal, 209 :5-13. [Details]
Hill EW, Gu J, Eivers SS, Fonseca RG, McGivney BA, Govindarajan P, Orr N, Katz LM, MacHugh DE; (2010) 'A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses'. PLoS ONE, 5 (1):null-null. Available Online [DOI] [Details]
Eivers SS, McGivney BA, Fonseca RG, MacHugh DE, Menson K, Park SD, Rivero JLL, Taylor CT, Katz LM, Hill EW; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiological Genomics, 40 (2):83-93. Available Online [DOI] [Details]
Hill EW, McGivney BA, Gu J, Whiston R, MacHugh DE; (2010) 'A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses'. BMC Genomics, 11 (1):552-null. Available Online [DOI] [Details]
McGivney, B.A., McGettigan, P.A., Browne, J.A., Evans, A.C., Fonseca, R.G., Loftus, B.J., Lohan, A., MacHugh, D.E., Murphy, B.A., Katz, L. M., Hill, E.W.; (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 (null):398398-null. Available Online [DOI] [Details]
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, Ducro B, Van Arendonk JAM, MacHugh DE, Ennis S, Hill EW, Brama PAJ ; (2010) 'Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses'. Animal Genetics, 41 (suppl. 2):2-7. Available Online [DOI] [Details]
Fonseca, R.G., Kenny, D., Hill, E.W., Katz, L.M.; (2010) 'The association of various speed indices to training responses in Thoroughbred flat racehorses measured with a global positioning and heart rate monitoring system'. Equine Veterinary Journal Supplement, 42 (38):51-57. Available Online [DOI] [Details]
Hill, E.W., Eivers, S.S., McGivney, RG., Fonseca, GU. J., Smith, N.A., Browne, J.A., MacHugh, D.E., Katz, L.M.; (2010) 'Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle'. Equine Veterinary Journal Supplement, 42 (38):576-581. Available Online [DOI] [Details]
Martin, A.M., Elliott, J.A., Duffy, P., Blake, C., Attia, S.B., Browne, J.A., Katz, L.M., Gath, V., McGivney, B.A., Hill, E.W., Murphy, B.A. ; (2010) 'Circadian regulation of locomotor activity and skeletal muscle gene expression in the horse'. Journal of Applied Physiology, 109 (5):1328-1336. Available Online [DOI] [Details]
Bower MA, Whitten M, Nisbet RER, Spencer M, Dominy KM, Murphy AM, Cassidy R, Barrett E, Hill EW, Binns M.; (2010) 'Thoroughbred horse mitochondrial DNA demonstrates closer than expected links between maternal genetic history and pedigree records'. Equine Veterinary Journal, . [Details]
Gu J, MacHugh DE, McGivney BA, Park SDE, Katz LM, Hill EW; (2010) 'Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses'. Equine Veterinary Journal Supplement, 42 (38):569-575. Available Online [DOI] [Details]
Hill, E.W., Gu, J., McGivney, B.A., MacHugh, D.E.; (2010) 'Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance'. Animal Genetics, 41 (Suppl 2):56-63. Available Online [DOI] [Details]
Hill EW; (2010) 'Editorial, Livestock issue'. Briefings in Functional Genomics, 9 (3):191-192. [Details]
O'Gorman GM, Park SD, Hill EW, Meade KG, Coussens PM, Agaba M, Naessens J, Kemp SJ, Machugh DE; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. BMC Genomics, . [Details]
Gu J, Orr N, Park SD, Katz LM, Sulimova G, MacHugh DE, Hill EW; (2009) 'A genome scan for positive selection in thoroughbred horses'. PLoS ONE, 4 (6). Available Online [DOI] [Details]
McGivney BA, Eivers SS, MacHugh DE, MacLeod JN, O'Gorman GM, Park SD, Katz LM, Hill EW; (2009) 'Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy'. BMC Genomics, 10 :638. Available Online [DOI] [Details]
Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MC, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, Nergadze SG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE, Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Lander ES, Lindblad-Toh K.; (2009) 'Genome sequence, comparative analysis, and population genetics of the domestic horse'. Science, 326 (5954):865-867. [Details]
McGahern AM, Edwards CJ, Bower MA, Heffernan A, Park SD, Brophy PO, Bradley DG, MacHugh DE, Hill EW; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Animal Genetics, 37 (5):498-502. [DOI] [Details]
Tozaki T, Sato F, Hill EW, Miyake T, Endo Y, Kakoi H, Gawahara H, Hirota K, Nakano Y, Nanbo Y, Kurosawa M; (2011) 'Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses'. The Open Veterinary Science Journal, null (Aug11):null-null. Available Online [DOI] [Details]
Tozaki T, Hill EW, Hirota K, Kakoi H, Gawahara H, Miyake T, Sugita S, Hasegawa T, Ishida N, Nakano Y, Kurosawa M. ; (2011) 'A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18'. Animal Genetics, null (null):null-null. Available Online [DOI] [Details]
Hanotte O, Bradley DG, Ochieng JW, Verjee Y, Hill EW, Rege JE.; (2002) 'African pastoralism: genetic imprints of origins and migrations'. Science, 296 (5566):336-339. [Details]
13. Bower M, Campana M, Whitten C, Edwards C, Jones H, Barrett E, Cassidy R, Nisbet RE, Hill EW, Howe C, Binns M.; (2010) 'The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish Native mares'. Biology Letters, Oct 6 (null):null-null. Available Online [DOI] [Details]
Hill E.W., Al Barody M., Bradley D.G., Ertugrul O., Splan R.K., Zakharov I. & Cunningham E.P.; (2002) 'History and integrity of thoroughbred dam lines revealed in equine mtDNA variation'. ANIMAL GENETICS, 33 :287-294. [Details]
Rosser Z.H., ['] Hill E.W., ['] & Jobling M.A.; (2002) 'Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1526-1543. [Details]
Richards M., ['] Hill E. W., ., ['] & Stefanescu G.; (2000) 'Tracing European founder lineages in the Near Eastern mtDNA pool'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1251-1276. [Details]
Helgason A., ., ['], Hill E.W., ., ['] & Stefansson K.; (2000) 'Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :697-717. [Details]
Hill E.W., Jobling, M.A. & Bradley, DG; (2000) 'Y chromosomes and Irish origins'. NATURE, 404 :351-352. [Details]
Achukwi M.D., Tanya, V.N., Hill, E.W., Bradley, D.G., Meghen, C., Sauveroche, B., Banser, J.T. & Ndoke, J.N.; (1997) 'Susceptibility of the Namchi and Kapsiki cattle of Cameroon to trypanosome infection'. TROPICAL ANIMAL HEALTH AND PRODUCTION, 29 :219-226. [Details]

Other Journals

Rooney, MF; Hill, EW; Katz, LM; Porter, RK (2016) 'MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses' Biochimica et Biophysica Acta (BBA)-Bioenergetics 1857 :e31. [Details]
Fonseca, RG; Kenny, DA; McGivney, BM; Murphy, BA; Hill, EW; Katz, LM (2016) 'Effect of training on plasma myeloperoxidase concentrations measured before and following intense exercise in Thoroughbred racehorses' Comparative Exercise Physiology 12 (1) :17-25. [DOI] [Details]

Conference Publications

Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training pression in Thoroughbred racehorses 6th International Symposium on Animal Functional Genomics (ISAFG) [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training progression in Thoroughbred racehorses Computational Biology and Innovation Symposium [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thorougbred racehorses Conway Festival of Research & Innovation [Details]
Herdan, C; Sweeney, J; Gough, KF; Hill, EW; Katz, LM (2016) Intra-horse variation on overground endoscopy 2016 ACVS Surgery Summit Veterinary Symposium [Details]
Rooney, MF; Hill, EW; Katz, LM; Porter, RK (2016) MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre compostition in untrained Thoroughbred horses 19th European Bioenergetics Conference [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thoroughbred racehorses Australasian Equine Science Symposium [Details]
Emmeline W Hill1, Beatrice A McGivney, Heather L Wiencko, Andrew C Parnell, Gabriella Farries, Kenneth Bryan, Lisa M Katz4, David E MacHugh (2017) Predictive genetic markers for racing durability and the identification of an exercise-mediating behavioural response gene Cell Symposium on Exercise Metabolism [Details]
G. Farries, B.A. McGivney, K.F. Gough, L.M. Katz, E.W. Hill (2017) Genetic contributions to measured speed variables in Thoroughbred racehorses during early training Cell Symposium on Exercise Metabolism [Details]
Haige, H., Bryan, K., Shiraigol, W., MacHugh, D. E., Dugarjaviin, M., Hill, E. W. (2017) Genetic Diversity and Population Structure in Chinese Mongolian Horses 36th International Society for Animal Genetics Conference Dublin, Ireland, [Details]
Haige, H., Bryan, K., Shiraigol, W., MacHugh, D. E., Dugarjaviin, M., Hill, E. W. (2017) Genetic Diversity and Population Structure in Chinese Mongolian Horses UCD Conway Festival of Research and Innovation Dublin, Ireland, [Details]
Bryan, K., McGivney, B., Farries, G., Gough, K., McGivney, C., MacHugh, D., Katz, L., Hill E. (2017) Evidence for a transcriptome-driven variant-specific functional effect of the equine myostatin (MSTN) performance SNP (g.66493737C>T) Cell Symposium on Exercise Metabolism Gothenburg, Sweden, [Details]
Matthew C Weiser, Beatrice A McGivney, Heather L Wiencko and Emmeline W Hill (2017) Leveraging betting market data to derive accurate and heritable racing performance phenotypes in Thoroughbred horses Cell Symposium Exercise Metabolism [Details]
Hill, E. W., Oâ¿¿Gorman, G. M., Gormley, E., Fitzsimons, T., Rosa, G J.M., Coussens, P. M., MacHugh, D. E. (2003) Functional genomics analysis of the bovine immune response to Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei) Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
MacHugh, D. E., Meade, K.G., O'Gorman, G. M., Gormley, E., Rosa, G J.M., Coussens, P. M., Hill, E. W. (2003) Using gene expression technologies to analyse the bovine immune response to pathogens and parasitesUsing gene expression technologies to analyse the bovine immune response to pathogens and parasites Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
MacHugh, D. E., Meade, K.G., O'Gorman, G. M., Gormley, E., Rosa, G J.M., Coussens, P. M., Hill, E. W. (2003) Using gene expression technologies to analyse the bovine immune response to pathogens and parasites. Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
Hill, E. W., Oâ¿¿Gorman, G. M., Gormley, E., Fitzsimons, T., Rosa, G J.M., Coussens, P. M., MacHugh, D. E. (2003) Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei).. Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
Hill, E.W., O'Gorman, G.M., Gormley, E., Fitzpatrick, T., Rosa, G J.M., Coussens P.M., MacHugh, D.E. (2003) Functional genomics analysis of the bovine immune response to Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei) Proceedings of the International Symposium on Animal Functional Genomics Michigan State University, USA, [Details]
Hill, E.W., O'Gorman, G.M., Gormley, E., Fitzpatrick, T., Rosa, G J.M., Coussens P.M., MacHugh, D.E. (2003) Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei). Proceedings of the International Symposium on Animal Functional Genomics Michigan State University, USA, [Details]
Hill, E. W., O'Gorman, G. M., Agaba, M., Gibson, J. P., Hanotte, O., Kemp, S. J., Naessens, J., Coussens, P. M., MacHugh, D. E. (2004) Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics.. Proceedings of: 1st International Conference on Basic and Clinical Immunogenomics Budapest, Hungary, [Details]
Hill, E. W., O'Gorman, G. M., Agaba, M., Gibson, J. P., Hanotte, O., Kemp, S. J., Naessens, J., Coussens, P. M., MacHugh, D. E. (2004) Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics.Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics Proceedings of: 1st International Conference on Basic and Clinical Immunogenomics Budapest, Hungary, [Details]
McGahern, A., Hill, E.W., MacHugh, D.E., Brophy, P. O. (2005) A molecular genetic characterisation of the endangered Irish Draught horse. Proceedings of the Agricultural Research Forum Tullamore, Co. Offaly, Ireland, , pp.9 [Details]
McGahern, A., Hill, E.W., MacHugh, D.E., Brophy, P. O. (2005) A molecular genetic characterisation of the endangered Irish Draught horseA molecular genetic characterisation of the endangered Irish Draught horse Proceedings of the Agricultural Research Forum Tullamore, Co. Offaly, Ireland, , pp.9 [Details]
O'Gorman, GM,Park, SDE,Hill, EW,Meade, KG,Mitchell, LC,Agaba, M,Gibson, JP,Hanotte, O,Naessens, J,Kemp, SJ,MacHugh, DE (2006) Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense PHYSIOLOGICAL GENOMICS , pp.53-61 [DOI] [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., MacHugh, D. E. (2006) A functional genomics study of trypanotolerant and trypanosusceptible African cattle during A functional genomics study of trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense Infection Proceedings of: 2nd International Symposium on Animal Functional Genomics (ISAFG) Michigan State University, USA, [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., MacHugh, D. E. (2006) A functional genomics study of trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense Infection.. Proceedings of: 2nd International Symposium on Animal Functional Genomics (ISAFG) Michigan State University, USA, [Details]
Hill EW, SS Eivers, BA McGivney, DE MacHugh, C Taylor, K Mason, J MacLeod, LM Katz (2008) Exercise-induced gene expression in equine skeletal muscle 3rd International Symposium on Animal Functional Genomics (ISAFG) [Details]
Eivers, S., McGivney, B., MacHugh, D. E., Taylor, C. T., Mason, K., MacLeod, J., Katz, L. M., Hill, E. W. (2008) Exercise-induced gene expression in equine skeletal muscleExercise-induced gene expression in equine skeletal muscle Proceedings of: International Society for Animal Genetics Conference (ISAG 2008) Amsterdam,The Netherlands, [Details]
Gu, J., MacHugh, D. E., Hill, E. W. (2008) A whole genome scan for regions of positive selection in thoroughbred racehorsesA whole genome scan for regions of positive selection in thoroughbred racehorses Proceedings of: 3rd International Symposium on Animal Functional Genomics (ISAFG) Edinburgh International Conference Centre, Edinburgh, UK, [Details]
O'Gorman, G. M., Park, Stephen D. E., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, David E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infectionTranscriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection Proceedings of Plant and Animal Genome XVI Town and Country Hotel, San Diego, USA, [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, D. E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection.. Proceedings of: Plant and Animal Genome XVII Conference Town & Country Convention Center, San Diego, California, USA, [Details]
O'Gorman, G. M., Park, Stephen D. E., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, David E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection. Proceedings of Plant and Animal Genome XVI Town and Country Hotel, San Diego, USA, [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, D. E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection Proceedings of: Plant and Animal Genome XVII Conference Town & Country Convention Center, San Diego, California, USA, [Details]
McGivney, B., Eivers, S. S., Katz, L. M., MacLeod, J., MacHugh, D. E., O'Gorman, G. M., Park, S. D., Hill, E. W. (2008) Transcriptional profiling of thoroughbred skeletal muscle response to exercise using an equine cDNA microarrayTranscriptional profiling of thoroughbred skeletal muscle response to exercise using an equine cDNA microarray Proceedings of: 3rd International Symposium on Animal Functional Genomics (ISAFG) Edinburgh International Conference Centre, Edinburgh, UK, [Details]
McGivney, B. A., McGettigan, P., Browne, J. A., Fonseca, R. G., Eivers, S. S., Evans, A. C., Loftus, B. J., Lohan, A., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Digital gene expression profiling in Thoroughbred horse skeletal muscle following exercise trainingDigital gene expression profiling in Thoroughbred horse skeletal muscle following exercise training Proceedings of The Physiological Society Meeting University College Dublin, Dublin, Ireland, [Details]
Eivers, S. S., Gu, J., McGivney, B. A., Fonseca, R. G., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Targets of selection in the Thoroughbred horse (Equus caballus) genome contain genes expressed in skeletal muscle following exercise Proceedings of 14th International Biochemistry of Exercise Conference University of Guelph, Ontario, Canada, [Details]
Meade, K. G., Oâ¿¿Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle. Proceedings of the Irish Society for Immunology Annual General Meeting Institute of Molecular Medicine, St. James Hospital, Dublin, Ireland, [Details]
Meade, K. G., Oâ¿¿Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattleDivergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle Proceedings of the Irish Society for Immunology Annual General Meeting Institute of Molecular Medicine, St. James Hospital, Dublin, Ireland, [Details]
McGivney, B. A., McGettigan, P., Browne, J. A., Fonseca, R. G., Eivers, S. S., Evans, A. C., Loftus, B. J., Lohan, A., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Digital gene expression profiling in Thoroughbred horse skeletal muscle following exercise training. Proceedings of The Physiological Society Meeting University College Dublin, Dublin, Ireland, [Details]
Meade, K. G., O'Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle ISI Annual Meeting 2009 Institute of Molecular Medicine, St James Hospital, Dublin 8, Ireland, [Details]
Meade, K. G., O'Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle. ISI Annual Meeting 2009 Institute of Molecular Medicine, St James Hospital, Dublin 8, Ireland, [Details]
Gu J, MacHugh DE, Park SDE, Katz LM, Hill EW; (2010) Sequence variants in equine CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes are associated with elite racing performance in Thoroughbred horses 8th International Conference on Equine Exercise Physiology [Details]
Hill EW, Eivers SS, McGivney BA, Fonseca RG, Gu J, Smith N, Browne J, MacHugh DE, Katz LM; (2010) Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle 8th International Conference on Equine Exercise Physiology [Details]
Hill, E. W., Gu, J., Eivers, S. S., Fonseca, R. G., McGivney, B. A., Govindarajan, P., Orr, N., Katz, L. M., MacHugh, D. E. (2010) A sequence polymorphism in the MSTN gene predicts sprinting ability and racing stamina in Thoroughbred horses Proceedings of the Annual General Meeting of the Irish Thoroughbred Breeder's Association Kill, Ireland, [Details]
Hill, E. W., Gu, J., Eivers, S. S., Fonseca, R. G., McGivney, B. A., Govindarajan, P., Orr, N., Katz, L. M., MacHugh, D. E. (2010) A sequence polymorphism in the MSTN gene predicts sprinting ability and racing stamina in Thoroughbred horses. Proceedings of the Annual General Meeting of the Irish Thoroughbred Breeder's Association Kill, Ireland, [Details]
Fonseca RG, Kenny DA, McGivney BA, Murphy BA, Hill EW, Katz LM; (2011) The response of plasma myeloperoxidase concentrations to exercise and training in a group of Thoroughbred flat racehorses over a two-year period of time French Equine Veterinary Association (AVEF) [Details]
McGivney, B. A., Whiston, R., Browne, J. A., Fonseca, R. G., Gu, J., Katz, L. M., MacHugh, D. E., Hill, E. W. (2011) Investigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscleInvestigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscle Proceedings of the 4th International Symposium on Animal Functional Genomics (ISAFG) Dublin, Ireland, [Details]
McGivney, B. A., Whiston, R., Browne, J. A., Fonseca, R. G., Gu, J., Katz, L. M., MacHugh, D. E., Hill, E. W. (2011) Investigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscle. Proceedings of the 4th International Symposium on Animal Functional Genomics (ISAFG) Dublin, Ireland, [Details]
Carberry, C., McGivney, B. A., McLoughlin, K., MacHugh, D. E., Hill, E. W. (2013) A genome wide association study to identify SNPs associated with precocity in the Thoroughbred (Flat) racehorse Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
MacHugh, D. E., McGivney, B. A., Killick, K. E., McGettigan, P. A., Gu, J., Carberry, C., Hill, E. W. (2013) A pooled high-throughput sequencing approach to identify novel equine SNPs and associations with elite Thoroughbred racing performance Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
Hill, E. W., McGivney, B. A., Donovan, G., Gough, K., Carberry, C., MacHugh, D. E. (2013) SNP associations with height in the Thoroughbred (Flat) racehorseSNP associations with height in the Thoroughbred (Flat) racehorse Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
McGettigan, P. A., Farries, G., Browne, J. A., McGivney, B. A., Herdan, C., Gough, K., Katz, L. M., MacHugh, D. E., Hill, E. W. (2014) Field study of Thoroughbred racehorse muscle transcriptomic response to exercise pre- and post-training using RNA-seq Proceedings of the EMBL-EBI Livestock Genomics Meeting Homerton College, Cambridge, UK, [Details]
Hill EW, BM McGivney, C Herdan, K Gough, LM Katz (2014) Investigation of MSTN genotype association with VO2peak in untrained yearlings 9th International Conference on Equine Exercise Physiology [Details]
Hill, E. W., McGettigan, P. A., Parnell, A. C., Ryan, D., MacHugh, D. E. (2015) Development of genomic prediction methods for elite racing performance in Thoroughbred racehorses 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
McGettigan, P. A., Farries, G., Browne, J. A., McGivney, B. A., Herdan, C., Gough, K., Katz, L. M., MacHugh, D. E., Hill, E. W. (2015) Field Study of Thoroughbred racehorse skeletal muscle gene expression response to exercise pre- and post-training using RNA-seq 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
Rue-Albrecht, K., McGettigan, P. A., Hernandez, B., Parnell, A. C., Gordon, S. V., Hill, E. W., MacHugh, D. E. (2015) GOexpress: analysis and visualisation of gene expression data using gene ontology annotations 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
       

Editorial

Hill, EW; (2010) Livestock Issue. Editorial [DOI] [Details]
                                                                                                                             

Research

Research Interests

The aim of the research programme is to perform extensive and intensive phenotyping of end-point exercise physiological performance parameters and endophenotypes associated with muscular and mitochondrial function to test the hypothesis that genetic variation, catalogued using state-of-the-art genomic technologies, contributes to functional micro-adaptations that are influenced by exercise and cumulatively increase aerobic capacity.

Genetic variation is being assessed in a large cohort of Thoroughbred horses in training:

·         Illumina Equine SNP70 genotyping array

·         Affymetrix Equine SNP670 genotyping array
 

To project will test the hypotheses that genetic variation:

1)      contributes to variation in measured end-point physiological exercise parameters

2)      is reflected in variation in skeletal muscle gene expression

3)      underpins complex pathological phenotypes leading to poor-performance

4)      influences variation in mitochondrial function

Additional projects:
Genetic variation among indigenous Chinese horse populations
Genetics of behavioural traits in Thoroughbred horses

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Genomics of performance in thoroughbred horses
Start Date / End Date : 01-OCT-04 / 31-MAR-10
Sponsor : Jim Bolger (JS Bolger)
Title : A genome-wide association study for Thoroughbred athletic performance using the EquineSNP50 Chip
Start Date / End Date : 01-DEC-08 / 31-DEC-10
Sponsor : University College Dublin (UCD)
Title : International Conference on Equine Exercise Physiology
Start Date / End Date : 03-AUG-09 / 31-JAN-11
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : An evaluation of dosage profiling and genomic analysis to predict the optimum racing distance for Thoroughbred horses and determination of the ancestral origin of the "speed" allele
Start Date / End Date : 01-DEC-10 / 30-NOV-11
Sponsor : University College Dublin (UCD)
Title : Influence of Genomic Class Test in Predicting Yearling Sale Price and Total Career Earnings of Racehorses
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Science Foundation Ireland (SFI)
Title : Integrated genomics approaches to understanding genetic contributions to system-wide exercise physiology parameters in a large animal model.
Start Date / End Date : 01-APR-12 / 31-MAR-19
Sponsor : Science Foundation Ireland (SFI)
Title : A promotional film illustrating world-class science in horse genomics and the impact on the global bloodstock industry
Start Date / End Date : 01-MAY-13 / 31-OCT-13
Sponsor : Equinome Ltd
Title : Using genomic technologies to investigate genetic associations with performance parameters in horses
Start Date / End Date : 01-APR-14 / 24-APR-15
Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19

Recent Postgraduates

Jingjing Gu, PhD 2009
Beatrice McGivney, PhD 2009
Suzanne Eivers, PhD 2009
Mary Rooney, PhD 2016 
Charlotte McGivney, PhD 2017 
Gabriella Farries, PhD 2018 

Current Postgraduate Students

Amy Holtby, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Haige Han, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Gabriella Farries, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

Teaching Philosophy

At the heart of my teaching is to develop real understanding, empowering students to critically evaluate and utilise science in equine management. There is no greater satisfaction to me as a teacher than to see the ¿eureka¿ moment in a student¿s face when the pieces of knowledge come together.

Modules Coordinated

201700   ANSC30210     Animal Science: Equine Industries
201700   ANSC40090     Animal Science: Equine Science Project
201700   ANSC30250     Animal Science: Equine Genetics

Enhancement of Teaching

The focus of my teaching is to generate real understanding such that students have the capacity to think critically. I always start lessons by attempting to connect new knowledge to prior experience or learning. I regularly ask students to compare and contrast ideas and identify the differences between the two. All of my modules have 20-30 students, which enables student-teacher interaction throughout the lectures. I constantly engage the students by asking questions, such that they have to think about the knowledge that is being imparted. I also strongly encourage students to ask questions during lectures and to think ahead. "In lectures a huge effort was made to ensure we understood." The external examiners reports have consistently commented on the standard of performance in the Equine Science Project module. This supports the strategy that I take in tutorials to provide students with the skills to develop their ideas by critically examining their peers' approaches to their research. External Examiners Report: 2010/11: "Most impressive was student performance in the Animal Science and Equine Science Project courses (ANSC30180 and 40090). Level of performance was high and best projects in both classes are suitable for publication as scientific research articles." Since 2010 Equine Science Projects have resulted in: - Irish Undergraduate Award (1) - Peer-reviewed journal publication (1) - Academic conference poster (2) - Invention disclosure to NovaUCD (1)

Review and Enhancement of Curriculum

There are no text books for any of my modules, therefore they are based on most recent published research (Equine Genetics) and knowledge gained through my personal experience (Equine Industries and Equine Science Project). This requires that each year lectures are updated. I take strong consideration of student feedback to improve content; e.g. responding to feedback, Dr Lisa Katz (Lecturer in Equine Veterinary Medicine) contributes to Equine Genetics to provide clinical relevance. I regularly engage with practitioners in the sector and have had formal discussions on requirements of graduates for the equine industries. My module content is designed to foster key learning attributes (e.g. oral presentations, which develop communication skills) and all have practical and self-learning elements which require critical evaluation of the learning gained during lectures. Assignments must be challenging, stimulating and enjoyable and my modules include: Field trips, media project, computer practicals, journal reviews, self-directed hypothesis driven research. "The module was very well thought out. A lot of effort was put in to make it enjoyable and understandable." "Media Project is a brilliant idea." I design assessments to maximise learning, requiring students to think for themselves and not regurgitate information (i.e. none of my modules include MCQ assessments). "[This module] made me think on my own. Encouraged me to form my own opinions of previous research work. Encouraged me to understand instead of learning off" The External Examiners Report: 2011/12 comments: "Special mention should be given to the opportunities created in various courses ( ANSC40090 among others) for development of critical thinking skills . These experiences, which require a great deal of effort on the part of faculty are very valuable for producing the kind of graduate who can compete in agribusiness and science.

Developing as a Teacher

I believe in learning by doing, and regularly avail of opportunities to speak about my work to outside audiences, challenging myself to accept invitations to speak 'outside my comfort zone', often communicating complex scientific ideas to lay audiences. I find that this serves as an ideal tool to frame, reflect on and articulate my role, philosophies and priorities as a university educator. In this regard, I have lectured to diverse audiences and participated in public panel discussions and forums. Working in an academic environment affords many opportunities to think about and develop an understanding of ideas, not just those directly related to research, but also about entrepreneurship, management and teaching. Over the years, I have had the opportunity to expand and apply the basic ethos of student centred and active learning that I acquired through working in the UN-FAO by: - Actively seeking to review learning outcomes through carefully reviewing assessment - Discussing and reflecting on learning styles, approaches and outcomes with colleagues - Occasional reading including accessing UCD teaching and learning resources and texts related to curriculum, teaching and learning.

Innovation & Leadership

I was central to the development of the Animal Science - Equine degree programme, which has core modules aligned directly to my research. I conceived and developed the proposal for a taught Masters Programme in Applied Equine Science in response to industry requirements. Equine science education at UCD has largely grown around my research programme in equine genomics.

Collaborators

Internal Collaborators

Associate Prof Lisa Katz, School of Veterinary Medicine
Prof David MacHugh, School of Agriculture and Food Science
                      

External Collaborators

International Horse Genomics Group
Prof Richie Porter, Trinity College Dublin
Prof Warwick Bayly, Washington State University
Prof D Manglai, Inner Mongolia Agriculture University
Dr Teruaki Tozaki, Laboratory for Racing Chemistry, Japan
Dr I Randhawa, University of Sydney, Australia