Navigation

Researchers at UCD

researcher

Emmeline Hill

Associate Professor

School Of Agriculture & Food Science
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166231
Email: emmeline.hill@ucd.ie

Biography

1991-1995: BA (mod Genetics), Trinity College Dublin
1995-1999: Ph.D., Trinity College Dublin
1998-1999: Research Associate, International Livestock Research Institute, Kenya
1999-2000: Research Consultant, FAO of the United Nations
2000-2001: Postdoctoral Researcher, Trinity College Dublin
2002-2004: Postdoctoral Researcher, University College Dublin
2004-2010: Science Foundation Ireland President of Ireland Young Researcher Award
2009: Co-founder Equinome Ltd
2004: College Lecturer in Equine Science
2012-2017: Science Foundation Ireland Principal Investigator Award
2014: Senior Lecturer in Equine Science
2015: Chief Science Officer Plusvital Ltd
2016: Associate Professor of Equine Science


Professional

Honours and Awards

Year: 2016.
Title: SFI Best Reported Impact Award
Year: 2011.
Title: Business Entrepreneur of the Year Award
Year: 2010.
Title: Entrepreneur of the Year Award
Year: 2009.
Title: Campus Company Development Programme Start-Up Award
Year: 2004.
Title: President of Ireland Young Researcher Award
Year: 2012.
Title: Irish Tatler Entrepreneur of the Year Award
Year: 2014.
Title: UCD Innovation Award
       

Conference Contributions

Hill, E.W.,O'Gorman, G.M.,Gormley, E.,Fitzpatrick, T.,Rosa, G J.M.,Coussens P.M.,MacHugh, D.E.; (2003) Proceedings of the International Symposium on Animal Functional Genomics. [Published Abstract], Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei), Michigan State University, USA .
Emmeline Hill; (2005) British Association Festival of Science 2005. [Invited Oral Presentation], British Association Festival of Science 2005, Dublin , 03-SEP-05 - 10-SEP-05.
Emmeline Hill; (2005) British Equine Veterinary Association Congress 2005. [Invited Oral Presentation], British Equine Veterinary Association Congress 2005, Harrogate, UK , 14-SEP-05 - 17-SEP-05.
Emmeline Hill; (2006) Horse Genetic Diversity - What we know and what we'd like to know. [Invited Oral Presentation], International Horse Genome Project Planning Workshop, The Broad Institute, MIT, Boston , 27-APR-06 - 27-APR-06.
Hill EW, SS Eivers, BA McGivney, RG Fonseca, J Gu, N Smith, J Browne, DE MacHugh, LM Katz; (2010) Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle. [Published Abstract], 8th International Conference on Equine Exercise Physiology, South Africa , 03-SEP-10 - 06-SEP-10.
McGettigan, PA; Farries, G; Browne, JA; McGivney, BA; Herdasn, C; Gough, K; Katz, LM; MacHugh, DE; Hill, EW (2014) Field study of Thoroughbred racehorse muscle transcriptomic response to exercise pre- and post-training using RNA-seq. [Oral Presentation], EMBL-EBI Livestock Genomics Meeting, Homerton College, Cambridge, UK , 18-SEP-14 - 20-SEP-14.
Hill EW, BM McGivney, C Herdan, K Gough, LM Katz (2014) Investigation of MSTN genotype association with VO2peak in untrained yearlings. [Oral Presentation], 9th International Conference on Equine Exercise Physiology, Chester, UK , 16-JUN-14 - 20-JUN-14.
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training progression in Thoroughbred racehorses. [Oral Presentation], Computational Biology and Innovation Symposium, Dublin, Ireland , 03-DEC-15 - 04-DEC-15.
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training progression in Thorougbred racehorses. [Poster Presentation (Refereed)], 6th International Symposium on Animal Funcitonal Genomics (ISAFG) conference, Piacenza, Italy , 27-JUL-15 - 29-JUL-15.
McGettigan, PA; Farries, G; Browne, JA; McGivney, BA; Herdan, C; Gough, K; Katz, LM; MacHugh, DE; Hill, EW (2015) Field study of Thorougbred racehorse muscle transcriptomic response to exercise pre- and post-training using RNA-seq. [Poster Presentation], Proceedings of the 11th Dorothy Russell Havemyer Foundation- International Equine Genome Mapping Workshop, Hannover, Germany , 22-JUL-15 - 25-JUL-15.
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thoroughbred racehorses. [Oral Presentation], Australasian Equine Science Symposium, Queensland, Australia , 08-JUN-16 - 10-JUN-16.
Herdan, C; Sweeney, J; Gough, KF; Hill, EW; Katz, LM (2016) Intra-horse variation on overground endoscopy. [Oral Presentation], 2016 ACVS Surgery Summit Veterinary Symposium, Seattle, WA, USA , 06-OCT-16 - 08-OCT-16.
Rooney, MF; Hill, EW; Katz, LM; Porter, RK (2016) MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre coposition in untrained Thoroughbred horses. [Poster Presentation (Refereed)], 19th European Bioenergetics Conference, Riva del Garda, Italy , 02-JUL-16 - 07-JUL-16.
Farries, G; McGettigan, PA; Gough, KF; Mcgiveny, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thoroughbred racehorses. [Oral Presentation], Conway Festival of Research and Innovation, Dublin, Ireland , 13-SEP-16 - 15-SEP-16.
Hill, EW; McGivney, BA; Wiencko, HL; Parnell, AC; Farries, G; Bryan, K; Katz, LM; MacHugh, DE (2017) Predictive genetic markers for racing durability and the identification of an exercise-mediating behavioural response gene. [Poster Presentation], CELL Symposia: Exercise Metabolism, Gothenburg, Sweden , 21-MAY-17 - 23-MAY-17.
Farries, G; McGivney, BA; Gough, KF; Katz, LM; Hill, EW (2017) Genetic contributions to measured speed variables in Thoroughbred racehorses during earling training. [Oral Presentation], International Society of Animal Genomics, Dublin, Ireland , 17-JUL-17 - 21-JUL-17.
Bryan, K; McGivney, BA; Farries, G; Gough, KF; MacHugh, DE; Katz, LM Hill, EW (2017) Evidence for a transcriptome-driven variant-specific functional effect of the equine myostatin (MSTN) performance SNP (g.66493737C>T). [Poster Presentation], CELL Symposia: Exercise Metabolism, Gothenburg, Sweden , 21-MAY-17 - 23-MAY-17.
Farries, G; McGivney, BA; Gough, KF; Katz, LM; Hill, EW (2017) Genetic contributions to measured speed variables in Thoroughbred racehorses during early training. [Poster Presentation], CELL Symposia: Exercise Metabolism, Gothenburg, Sweden , 21-MAY-17 - 23-MAY-17.
McGivney, C; Katz, LM; Hill, EW (2017) Identification of genetic risk loci for recurrent laryngeal neuropathy in the Thoroughbred horse. [Invited Oral Presentation], World Equine Airway Symposium, Copenhagen, Denmark , 13-JUL-17 - 15-JUL-17.
 

Employment

Employer: University College Dublin
Position: Postodctoral Researcher
Employer: UN Food and Agriculture Organization
Position: Consultant
Employer: Trinity College Dublin
Position: Postdoctoral Researcher

Education

Year 1995 Institution:
Qualification: BA Subject:
Year 1999 Institution:
Qualification: PhD Subject:
         

Publications

 

Book Chapters

Emmeline W. Hill, Bart J. Ducro, P. René van Weeren, Albert Barneveld, Willem Back (2013) 'Genetic contributions to exercise and athletic performance' In: Back and Clayton (eds). Equine Locomotion. USA: Saunders Ltd / Elsevier. [Details]
Hill EW, Katz LM, MacHugh DE; (2013) 'Genomics of Performance' In: Chowdhary B (eds). Equine Genomics. Hoboken, NJ: Wiley-Blackwell. , pp.265-284 [Details]
 

Peer Reviewed Journals

McGivney, B.A., McGettigan, P.A., Browne, J.A., Evans, A.C., Fonseca, R.G., Loftus, B.J., Lohan, A., MacHugh, D.E., Murphy, B.A., Katz, L. M., Hill, E.W.; (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 (null):398398-null. Available Online [DOI] [Details]
Fonseca, RG; Kenny, DA; McGivney, BM; Murphy, BA; Hill, EW; Katz, LM (2016) 'Effect of training on plasma myeloperoxidase concentrations measured before and following intense exercise in Thoroughbred racehorses'. Comparative Exercise Physiology, 12 (1):17-25. [DOI] [Details]
Farries G, McGettigan PA, Gough KF, McGivney BA, MacHugh DE, Katz LM, Hill EW. (2017) 'Genetic contributions to precocity traits in racing Thoroughbreds'. Animal Genetics, . [DOI] [Details]
Katz, LM; McGivney, BM; Fonseca, R; Hill, EW (2014) 'Candidate gene SNP associations with fat-free mass (FFM) measurements in horses in training'. Equine Veterinary Journal, 46 :35. [DOI] [Details]
McGivney, BM; Herdan, C; Gough, K; Katz, LM; Hill, EW (2014) 'Effect of training on PPARGC1A and FNDC5 gene expression in Thoroughbred horses'. Equine Veterinary Journal, 46 :35. [DOI] [Details]
Herdan, C; McGivney, BM; Gough, K; Hill, EW; Katz, LM (2014) 'A single nucleotide polymorphism (BIEC2-808543) on ECA3 is associated with recurrent laryngeal neuropathy independent of height in Thoroughbred horses'. Equine Veterinary Journal, 46 :34. [DOI] [Details]
Katz, LM; Gough, K; Herdan, C; McGivney, BM; Bayly, WM; Sides, R; Hill, EW (2014) 'Evaluation of a portable system designed to measure ventilatory parameters and oxygen consumption in unridden horses'. Equine Veterinary Journal, 46 :23. [DOI] [Details]
Hill, EW; McGivney BM; Herdan, C; Gough, K; Katz, LM (2014) 'Investigation of MSTN genotpe association with VO2peak in untrained yearlings'. Equine Veterinary Journal, 46 :35. [DOI] [Details]
Katz, LM; Mooney, LA; Gough, K; McGivney, CL; McCoughlan, M; Hill, EW; Anhold, H (2016) 'Evaluation of a portable analyzer for measuring hemoglobin concentrations and oxygen saturation in whole-blood samples from domestic animals'. Journal of Equine Veterinary Science, 45 :64-72. [DOI] [Details]
McGivney, CL; Sweeney, J; David, F; O'Leary, JM; Hill, EW; Katz, LM (2016) 'Intra- and inter-observer reliability estimates for identification and grading of upper respiratory tract abnormalities recorded in horses at rest and during overground endoscopy'. Equine Veterinary Journal, 49 :433-437. [DOI] [Details]
McGivney, BA; Griffin, M; Gough, KF; McGivney, CL; Browne, JA; Hill, EW; Katz, LM (2017) 'Evaluation of microRNA expression in plasma and skeletal muscle of Thoroughbred horses in training'. BMC Veterinary Research, 13 (1):347. [DOI] [Details]
Bryan K., McGivney B.A., Farries G. McGettigan P.A.. McGivney C.L., Gough K.F., MacHugh D.E., Katz L.M., Hill E.W. (2017) 'Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components'. BMC Genomics, 18 (1). [DOI] [Details]
Rooney, MF; Porter, RK; Katz, LM; Hill, EW (2017) 'Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse'. PLoS ONE, 12 (11):e0186247. [DOI] [Details]
Katz, LM; Gough, KF; McGivney, CL; Anhold, H; Hill, EW (2017) 'Effect of submaximal and high-intensity training on venous haemoglobin concentrations in Thoroughbred racehorses'. Journal of Equine Veterinary Science, 55 :34-39. [DOI] [Details]
Meade, K. G., Hill, E. W., Buckley, F., MacHugh, D. E. (2005) 'Convenient detection of single nucleotide polymorphism haplotypes in the bovine growth hormone gene using amplification-created restriction sites'. Animal Genetics, 36 (2):175-177. Available Online [Details]
Hill, EW,O'Gorman, GM,Agaba, M,Gibson, JP,Hanotte, O,Kemp, SJ,Naessens, J,Coussens, PM,MacHugh, DE; (2005) 'Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics'. Veterinary Immunology and Immunopathology, 105 :247-258. [DOI] [Details]
McGahern, A., Bower, M.A., Edwards, C.J., Brophy, P.O., Sulimova, G., Zakharov, I., Vizuete-Forster, M., Levine, M., Li, S., Machugh, D.E., Hill, E.W.; (2006) 'Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations'. Animal Genetics, 37 (5):494-7. [Details]
O'Gorman, GM; Park, SDE; Hill, EW; Meade, KG; Mitchell, LC; Agaba, M; Gibson, JP; Hanotte, O; Naessens, J; Kemp, SJ; MacHugh, DE; ; (2006) 'Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense'. Physiological Genomics, 28 (1):53-61. [Details]
O¿Gorman, G.M., Park, S.D.E. Hill, E.W. Meade, K.G. Coussens, P.M. Agaba, M., Naessens, J., Kemp, S.J., MacHugh, D.E.; (2008) 'Gene expression changes in peripheral blood mononuclear cells (PBMC) from African cattle infected with Trypanosoma congolense0 revealed by transcriptional profiling'. BMC Genomics, (in press) . [Details]
Gu, J.,Orr, N.,Park, S. D.,Katz, L. M.,Sulimova, G.,MacHugh, D. E.,Hill, E. W.; (2009) 'A genome scan for positive selection in thoroughbred horses'. PLoS One, 4 (66). Available Online [Details]
O'Gorman, G. M.,Park, S. D.,Hill, E. W.,Meade, K. G.,Coussens, P. M.,Agaba, M.,Naessens, J.,Kemp, S. J.,MacHugh, D. E.; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. BMC Genomics, 10 :207207. Available Online [Details]
Meade, KG,O'Gorman, GM,Hill, EW,Narciandi, F,Agaba, M,Kemp, SJ,O'Farrelly, C,MacHugh, DE; (2009) 'Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle'. Molecular Immunology, 47 :196-204. [DOI] [Details]
Wade, CM,Giulotto, E,Sigurdsson, S,Zoli, M,Gnerre, S,Imsland, F,Lear, TL,Adelson, DL,Bailey, E,Bellone, RR,Blocker, H,Distl, O,Edgar, RC,Garber, M,Leeb, T,Mauceli, E,MacLeod, JN,Penedo, MCT,Raison, JM,Sharpe, T,Vogel, J,Andersson, L,Antczak, DF,Biagi, T,Binns, MM,Chowdhary, BP,Coleman, SJ,Della Valle, G,Fryc, S,Guerin, G,Hasegawa, T,Hill, EW,Jurka, J,Kiialainen, A,Lindgren, G,Liu, J,Magnani, E,Mickelson, JR,Murray, J,Nergadze, SG,Onofrio, R,Pedroni, S,Piras, MF,Raudsepp, T,Rocchi, M,Roed, KH,Ryder, OA,Searle, S,Skow, L,Swinburne, JE,Syvanen, AC,Tozaki, T,Valberg, SJ,Vaudin, M,White, JR,Zody, MC,Lander, ES,Lindblad-Toh, K,Broad Inst Genome Sequencing Perfo,Broad Inst Whole Genome Assembly T; (2009) 'Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse'. Science AAAS, 326 :865-867. [DOI] [Details]
Eivers, S. S.,McGivney, B. A.,Fonseca, R. G.,MacHugh, D. E.,Menson, K.,Park, S. D.,Rivero, J. L.,Taylor, C. T.,Katz, L. M.,Hill, E. W.; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiological genomics, 40 (2):83-93. Available Online [Details]
Hill, EW,Gu, JJ,Eivers, SS,Fonseca, RG,McGivney, BA,Govindarajan, P,Orr, N,Katz, LM,MacHugh, D; (2010) 'A Sequence Polymorphism in MSTN Predicts Sprinting Ability and Racing Stamina in Thoroughbred Horses'. PLoS ONE, 5 . [DOI] [Details]
Gu, J,MacHugh, DE,McGivney, BA,Park, SDE,Katz, LM,Hill, EW; (2010) 'Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses'. Equine Veterinary Journal, 42 :569-575. [DOI] [Details]
Hill, EW,Eivers, SS,McGivney, BA,Fonseca, RG,Gu, J,Smith, NA,Browne, JA,MacHugh, DE,Katz, LM; (2010) 'Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle'. Equine Veterinary Journal, 42 :576-581. [DOI] [Details]
Fonseca, RG,Kenny, DA,Hill, EW,Katz, LM; (2010) 'The association of various speed indices to training responses in Thoroughbred flat racehorses measured with a global positioning and heart rate monitoring system'. Equine Veterinary Journal, 42 :51-57. [DOI] [Details]
Bower, MA,Campana, MG,Whitten, M,Edwards, CJ,Jones, H,Barrett, E,Cassidy, R,Nisbet, RER,Hill, EW,Howe, CJ,Binns, M; (2011) 'The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish native mares'. Biology Letters, 7 :316-320. [DOI] [Details]
Hill, E. W., Ryan, D. P., MacHugh, D. E. (2012) 'Horses for Courses: a DNA-based Test for Race Distance Aptitude in Thoroughbred Racehorses'. Recent Patents on DNA and Gene Sequences, 6 (3):203-8. Available Online [Details]
Hill, EW,Fonseca, RG,McGivney, BA,Gu, JJ,MacHugh, DE,Katz, LM (2012) 'MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses'. Journal of Applied Physiology, 112 :86-90. [DOI] [Details]
Tozaki, T,Hill, EW,Hirota, K,Kakoi, H,Gawahara, H,Miyake, T,Sugita, S,Hasegawa, T,Ishida, N,Nakano, Y,Kurosawa, M (2012) 'A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18'. Animal Genetics, 43 :42-52. [DOI] [Details]
Bower, MA,McGivney, BA,Campana, MG,Gu, JJ,Andersson, LS,Barrett, E,Davis, CR,Mikko, S,Stock, F,Voronkova, V,Bradley, DG,Fahey, AG,Lindgren, G,MacHugh, DE,Sulimova, G,Hill, EW (2012) 'The genetic origin and history of speed in the Thoroughbred racehorse'. Nature Communications, 3 . [DOI] [Details]
McCue, ME,Bannasch, DL,Petersen, JL,Gurr, J,Bailey, E,Binns, MM,Distl, O,Guerin, G,Hasegawa, T,Hill, EW,Leeb, T,Lindgren, G,Penedo, MCT,Roed, KH,Ryder, OA,Swinburne, JE,Tozaki, T,Valberg, SJ,Vaudin, M,Lindblad-Toh, K,Wade, CM,Mickelson, JR (2012) 'A High Density SNP Array for the Domestic Horse and Extant Perissodactyla: Utility for Association Mapping, Genetic Diversity, and Phylogeny Studies'. PLoS Genetics, 8 . [DOI] [Details]
Eivers, SS,McGivney, BA,Gu, J,MacHugh, DE,Katz, LM,Hill, EW (2012) 'PGC-1 alpha encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise'. Animal Genetics, 43 :153-162. [DOI] [Details]
Bower, MA,Campana, MG,Nisbet, RER,Weller, R,Whitten, M,Edwards, CJ,Stock, F,Barrett, E,O'Connell, TC,Hill, EW,Wilson, AM,Howe, CJ,Barker, G,Binns, M (2012) 'TRUTH IN THE BONES: RESOLVING THE IDENTITY OF THE FOUNDING ELITE THOROUGHBRED RACEHORSES'. Archaeometry, 54 :916-925. [DOI] [Details]
McGivney, BA,Browne, JA,Fonseca, RG,Katz, LM,MacHugh, DE,Whiston, R,Hill, EW (2012) 'MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance'. Animal Genetics, 43 :810-812. [DOI] [Details]
Moridi, M,Masoudi, AA,Torshizi, RV,Hill, EW (2013) 'Mitochondrial DNA D-loop sequence variation in maternal lineages of Iranian native horses'. Animal Genetics, 44 :209-213. [DOI] [Details]
Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara Machado A, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MC, Piercy RJ, Raekallio M, Rieder S, Røed KH, Silvestrelli M, Swinburne J, Tozaki T, Vaudin M, M Wade C, McCue ME (2013) 'Genetic diversity in the modern horse illustrated from genome-wide SNP data'. PLoS ONE, 8 (1). [DOI] [Details]
Petersen, JL,Mickelson, JR,Rendahl, AK,Valberg, SJ,Andersson, LS,Axelsson, J,Bailey, E,Bannasch, D,Binns, MM,Borges, AS,Brama, P,Machado, AD,Capomaccio, S,Cappelli, K,Cothran, EG,Distl, O,Fox-Clipsham, L,Graves, KT,Guerin, G,Haase, B,Hasegawa, T,Hemmann, K,Hill, EW,Leeb, T,Lindgren, G,Lohi, H,Lopes, MS,McGivney, BA,Mikko, S,Orr, N,Penedo, MCT,Piercy, RJ,Raekallio, M,Rieder, S,Roed, KH,Swinburne, J,Tozaki, T,Vaudin, M,Wade, CM,Mccue, ME (2013) 'Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds'. PLoS Genetics, 9 . [DOI] [Details]
Bower MA, Whitten M, Nisbet RE, Spencer M, Dominy KM, Murphy AM, Cassidy R, Barrett E, Hill EW, Binns M. (2013) 'Thoroughbred racehorse mitochondrial DNA demonstrates closer than expected links between maternal genetic history and pedigree records'. Journal of Animal Breeding and Genetics, 130 (3):227-235. [DOI] [Details]
Fonseca RG, Kenny DA, Hill EW, Katz LM. (2013) 'The relationship between body composition, training and race performance in a group of Thoroughbred flat racehorses'. Equine Veterinary Journal, . [DOI] [Details]
Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., Brama, P. A. (2013) 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10'. Animal Genetics, 44 (4):408-12. [Details]
Rivero JL, Hill EW. (2016) 'Skeletal muscle adaptations and muscle genomics of performance horses'. Veterinary Journal, 209 :5-13. [Details]
Hill EW, McGivney BA, Gu J, Whiston R, MacHugh DE; (2010) 'A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses'. BMC Genomics, 11 (1):552-null. Available Online [DOI] [Details]
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, Ducro B, Van Arendonk JAM, MacHugh DE, Ennis S, Hill EW, Brama PAJ ; (2010) 'Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses'. Animal Genetics, 41 (suppl. 2):2-7. Available Online [DOI] [Details]
Martin, A.M., Elliott, J.A., Duffy, P., Blake, C., Attia, S.B., Browne, J.A., Katz, L.M., Gath, V., McGivney, B.A., Hill, E.W., Murphy, B.A. ; (2010) 'Circadian regulation of locomotor activity and skeletal muscle gene expression in the horse'. Journal of Applied Physiology, 109 (5):1328-1336. Available Online [DOI] [Details]
Hill, E.W., Gu, J., McGivney, B.A., MacHugh, D.E.; (2010) 'Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance'. Animal Genetics, 41 (Suppl 2):56-63. Available Online [DOI] [Details]
McGivney BA, Eivers SS, MacHugh DE, MacLeod JN, O'Gorman GM, Park SD, Katz LM, Hill EW; (2009) 'Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy'. BMC Genomics, 10 :638. Available Online [DOI] [Details]
McGahern AM, Edwards CJ, Bower MA, Heffernan A, Park SD, Brophy PO, Bradley DG, MacHugh DE, Hill EW; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Animal Genetics, 37 (5):498-502. [DOI] [Details]
Tozaki T, Sato F, Hill EW, Miyake T, Endo Y, Kakoi H, Gawahara H, Hirota K, Nakano Y, Nanbo Y, Kurosawa M; (2011) 'Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses'. Journal of Veterinary Medical Science, 73 (Aug11):1617. [DOI] [Details]
Hanotte O, Bradley DG, Ochieng JW, Verjee Y, Hill EW, Rege JE.; (2002) 'African pastoralism: genetic imprints of origins and migrations'. Science, 296 (5566):336-339. [Details]
Hill E.W., Al Barody M., Bradley D.G., Ertugrul O., Splan R.K., Zakharov I. & Cunningham E.P.; (2002) 'History and integrity of thoroughbred dam lines revealed in equine mtDNA variation'. ANIMAL GENETICS, 33 :287-294. [Details]
Rosser Z.H., ['] Hill E.W., ['] & Jobling M.A.; (2002) 'Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1526-1543. [Details]
Richards M., ['] Hill E. W., ., ['] & Stefanescu G.; (2000) 'Tracing European founder lineages in the Near Eastern mtDNA pool'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1251-1276. [Details]
Helgason A., ., ['], Hill E.W., ., ['] & Stefansson K.; (2000) 'Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :697-717. [Details]
Hill E.W., Jobling, M.A. & Bradley, DG; (2000) 'Y chromosomes and Irish origins'. NATURE, 404 :351-352. [Details]
Achukwi M.D., Tanya, V.N., Hill, E.W., Bradley, D.G., Meghen, C., Sauveroche, B., Banser, J.T. & Ndoke, J.N.; (1997) 'Susceptibility of the Namchi and Kapsiki cattle of Cameroon to trypanosome infection'. TROPICAL ANIMAL HEALTH AND PRODUCTION, 29 :219-226. [Details]

Other Journals

Hill EW; (2010) 'Editorial, Livestock issue' Briefings in Functional Genomics 9 (3) :191-192. [Details]
Rooney, MF; Hill, EW; Katz, LM; Porter, RK (2016) 'MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses' Biochimica et Biophysica Acta (BBA)-Bioenergetics 1857 :e31. [Details]

Conference Publications

Farries, G., McGivney, B.A., Gough, K.F., Katz, L.M., Hill, E.W. (2017) Genetic contributions to measured speed variables in Thoroughbred racehorses during early training International Society of Animal Genomics Dublin, Ireland, [Details]
McGivney, C., Katz, L.M., Hill, E.W. (2017) Identification of genetic risk loci for Recurrent Laryngeal Neuropathy in the Thoroughbred horse World Equine Airway Symposium Copenhagen, Denmark, [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training pression in Thoroughbred racehorses 6th International Symposium on Animal Functional Genomics (ISAFG) [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2015) Genetic contributions to training progression in Thoroughbred racehorses Computational Biology and Innovation Symposium [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thorougbred racehorses Conway Festival of Research & Innovation [Details]
Herdan, C; Sweeney, J; Gough, KF; Hill, EW; Katz, LM (2016) Intra-horse variation on overground endoscopy 2016 ACVS Surgery Summit Veterinary Symposium [Details]
Rooney, MF; Hill, EW; Katz, LM; Porter, RK (2016) MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre compostition in untrained Thoroughbred horses 19th European Bioenergetics Conference [Details]
Farries, G; McGettigan, PA; Gough, KF; McGivney, BA; Katz, LM; Hill, EW (2016) Genetic contributions to age at peak performance in Thoroughbred racehorses Australasian Equine Science Symposium [Details]
Emmeline W Hill1, Beatrice A McGivney, Heather L Wiencko, Andrew C Parnell, Gabriella Farries, Kenneth Bryan, Lisa M Katz4, David E MacHugh (2017) Predictive genetic markers for racing durability and the identification of an exercise-mediating behavioural response gene Cell Symposium on Exercise Metabolism [Details]
G. Farries, B.A. McGivney, K.F. Gough, L.M. Katz, E.W. Hill (2017) Genetic contributions to measured speed variables in Thoroughbred racehorses during early training Cell Symposium on Exercise Metabolism [Details]
Haige, H., Bryan, K., Shiraigol, W., MacHugh, D. E., Dugarjaviin, M., Hill, E. W. (2017) Genetic Diversity and Population Structure in Chinese Mongolian Horses 36th International Society for Animal Genetics Conference Dublin, Ireland, [Details]
Haige, H., Bryan, K., Shiraigol, W., MacHugh, D. E., Dugarjaviin, M., Hill, E. W. (2017) Genetic Diversity and Population Structure in Chinese Mongolian Horses UCD Conway Festival of Research and Innovation Dublin, Ireland, [Details]
Bryan, K., McGivney, B., Farries, G., Gough, K., McGivney, C., MacHugh, D., Katz, L., Hill E. (2017) Evidence for a transcriptome-driven variant-specific functional effect of the equine myostatin (MSTN) performance SNP (g.66493737C>T) Cell Symposium on Exercise Metabolism Gothenburg, Sweden, [Details]
Matthew C Weiser, Beatrice A McGivney, Heather L Wiencko and Emmeline W Hill (2017) Leveraging betting market data to derive accurate and heritable racing performance phenotypes in Thoroughbred horses Cell Symposium Exercise Metabolism [Details]
Hill, E. W., Oâ¿¿Gorman, G. M., Gormley, E., Fitzsimons, T., Rosa, G J.M., Coussens, P. M., MacHugh, D. E. (2003) Functional genomics analysis of the bovine immune response to Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei) Proceedings of: Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
MacHugh, D. E., Meade, K.G., O'Gorman, G. M., Gormley, E., Rosa, G J.M., Coussens, P. M., Hill, E. W. (2003) Using gene expression technologies to analyse the bovine immune response to pathogens and parasites Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
Hill, E. W., Oâ¿¿Gorman, G. M., Gormley, E., Fitzsimons, T., Rosa, G J.M., Coussens, P. M., MacHugh, D. E. (2003) Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei) Science Foundation Ireland BIOT Meeting Killarney, Ireland, [Details]
Hill, E.W., O'Gorman, G.M., Gormley, E., Fitzpatrick, T., Rosa, G J.M., Coussens P.M., MacHugh, D.E. (2003) Functional genomics analysis of the bovine immune response to in vitro co-culture with trypanosomes (Trypanosoma brucei) International Symposium on Animal Functional Genomics Michigan State University, USA, [Details]
Hill, E. W., O'Gorman, G. M., Agaba, M., Gibson, J. P., Hanotte, O., Kemp, S. J., Naessens, J., Coussens, P. M., MacHugh, D. E. (2004) Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics 1st International Conference on Basic and Clinical Immunogenomics Budapest, Hungary, [Details]
McGahern, A., Hill, E.W., MacHugh, D.E., Brophy, P. O. (2005) A molecular genetic characterisation of the endangered Irish Draught horse Proceedings of the Agricultural Research Forum Tullamore, Co. Offaly, Ireland, , pp.9 [Details]
O'Gorman, GM,Park, SDE,Hill, EW,Meade, KG,Mitchell, LC,Agaba, M,Gibson, JP,Hanotte, O,Naessens, J,Kemp, SJ,MacHugh, DE (2006) Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense PHYSIOLOGICAL GENOMICS , pp.53-61 [DOI] [Details]
O'Gorman, G. M., Park, S. D., Hill, E. W., MacHugh, D. E. (2006) A functional genomics study of trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense Infection 2nd International Symposium on Animal Functional Genomics (ISAFG) Michigan State University, USA, [Details]
Hill EW, SS Eivers, BA McGivney, DE MacHugh, C Taylor, K Mason, J MacLeod, LM Katz (2008) Exercise-induced gene expression in equine skeletal muscle 3rd International Symposium on Animal Functional Genomics (ISAFG) [Details]
Gu, J., MacHugh, D. E., Hill, E. W. (2008) A whole genome scan for regions of positive selection in thoroughbred racehorsesA whole genome scan for regions of positive selection in thoroughbred racehorses Proceedings of: 3rd International Symposium on Animal Functional Genomics (ISAFG) Edinburgh International Conference Centre, Edinburgh, UK, [Details]
Oâ¿¿Gorman, G. M., Park, S. D., Hill, E. W., Agaba, M., Kemp, S. J., MacHugh, D. E. (2008) Transcriptional profiling of peripheral blood mononuclear cells (PBMC) from trypanotolerant and trypanosusceptible African cattle during Trypanosoma congolense infection Plant and Animal Genome XVII Conference Town & Country Convention Center, San Diego, California, USA, [Details]
McGivney, B., Eivers, S. S., Katz, L. M., MacLeod, J., MacHugh, D. E., O'Gorman, G. M., Park, S. D., Hill, E. W. (2008) Transcriptional profiling of thoroughbred skeletal muscle response to exercise using an equine cDNA microarrayTranscriptional profiling of thoroughbred skeletal muscle response to exercise using an equine cDNA microarray Proceedings of: 3rd International Symposium on Animal Functional Genomics (ISAFG) Edinburgh International Conference Centre, Edinburgh, UK, [Details]
Eivers, S. S., Gu, J., McGivney, B. A., Fonseca, R. G., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Targets of selection in the Thoroughbred horse (Equus caballus) genome contain genes expressed in skeletal muscle following exercise Proceedings of 14th International Biochemistry of Exercise Conference University of Guelph, Ontario, Canada, [Details]
McGivney, B. A., McGettigan, P., Browne, J. A., Fonseca, R. G., Eivers, S. S., Evans, A. C., Loftus, B. J., Lohan, A., MacHugh, D. E., Katz, L. M., Hill, E. W. (2009) Digital gene expression profiling in Thoroughbred horse skeletal muscle following exercise training The Physiological Society Meeting University College Dublin, Dublin, Ireland, [Details]
Meade, K. G., O'Gorman, G. M., Hill, E. W., Narciandi, F., Agaba, M., Kemp, S. J., O'Farrelly, C., MacHugh, D. E. (2009) Divergent antimicrobial peptide and acute phase protein responses to Trypanosoma congolense infection in tolerant and susceptible cattle ISI Annual Meeting Institute of Molecular Medicine, St James Hospital, Dublin 8, Ireland, [Details]
Gu J, MacHugh DE, Park SDE, Katz LM, Hill EW; (2010) Sequence variants in equine CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes are associated with elite racing performance in Thoroughbred horses 8th International Conference on Equine Exercise Physiology [Details]
Hill EW, Eivers SS, McGivney BA, Fonseca RG, Gu J, Smith N, Browne J, MacHugh DE, Katz LM; (2010) Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle 8th International Conference on Equine Exercise Physiology [Details]
Hill, E. W., Gu, J., Eivers, S. S., Fonseca, R. G., McGivney, B. A., Govindarajan, P., Orr, N., Katz, L. M., MacHugh, D. E. (2010) A sequence polymorphism in the MSTN gene predicts sprinting ability and racing stamina in Thoroughbred horses Proceedings of the Annual General Meeting of the Irish Thoroughbred Breeder's Association Kill, Ireland, [Details]
Fonseca RG, Kenny DA, McGivney BA, Murphy BA, Hill EW, Katz LM; (2011) The response of plasma myeloperoxidase concentrations to exercise and training in a group of Thoroughbred flat racehorses over a two-year period of time French Equine Veterinary Association (AVEF) [Details]
McGivney, B. A., Whiston, R., Browne, J. A., Fonseca, R. G., Gu, J., Katz, L. M., MacHugh, D. E., Hill, E. W. (2011) Investigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscleInvestigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscle Proceedings of the 4th International Symposium on Animal Functional Genomics (ISAFG) Dublin, Ireland, [Details]
McGivney, B. A., Whiston, R., Browne, J. A., Fonseca, R. G., Gu, J., Katz, L. M., MacHugh, D. E., Hill, E. W. (2011) Investigation of myostatin pathway gene expression in untrained and trained Thoroughbred horse skeletal muscle 4th International Symposium on Animal Functional Genomics (ISAFG) Dublin, Ireland, [Details]
Carberry, C., McGivney, B. A., McLoughlin, K., MacHugh, D. E., Hill, E. W. (2013) A genome wide association study to identify SNPs associated with precocity in the Thoroughbred (Flat) racehorse Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
MacHugh, D. E., McGivney, B. A., Killick, K. E., McGettigan, P. A., Gu, J., Carberry, C., Hill, E. W. (2013) A pooled high-throughput sequencing approach to identify novel equine SNPs and associations with elite Thoroughbred racing performance Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
Hill, E. W., McGivney, B. A., Donovan, G., Gough, K., Carberry, C., MacHugh, D. E. (2013) SNP associations with height in the Thoroughbred (Flat) racehorseSNP associations with height in the Thoroughbred (Flat) racehorse Proceedings of the 10th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Furnas, Sao Miguel, Azores, Portugal, [Details]
McGettigan, P. A., Farries, G., Browne, J. A., McGivney, B. A., Herdan, C., Gough, K., Katz, L. M., MacHugh, D. E., Hill, E. W. (2014) Field study of Thoroughbred racehorse muscle transcriptomic response to exercise pre- and post-training using RNA-seq Proceedings of the EMBL-EBI Livestock Genomics Meeting Homerton College, Cambridge, UK, [Details]
Hill EW, BM McGivney, C Herdan, K Gough, LM Katz (2014) Investigation of MSTN genotype association with VO2peak in untrained yearlings 9th International Conference on Equine Exercise Physiology [Details]
Hill, E. W., McGettigan, P. A., Parnell, A. C., Ryan, D., MacHugh, D. E. (2015) Development of genomic prediction methods for elite racing performance in Thoroughbred racehorses 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
McGettigan, P. A., Farries, G., Browne, J. A., McGivney, B. A., Herdan, C., Gough, K., Katz, L. M., MacHugh, D. E., Hill, E. W. (2015) Field Study of Thoroughbred racehorse skeletal muscle gene expression response to exercise pre- and post-training using RNA-seq 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
Rue-Albrecht, K., McGettigan, P. A., Hernandez, B., Parnell, A. C., Gordon, S. V., Hill, E. W., MacHugh, D. E. (2015) GOexpress: analysis and visualisation of gene expression data using gene ontology annotations 11th Dororthy Russell Havemeyer Foundation - International Equine Genome Mapping Workshop Leonardo Hotel, Hannover, Germany, [Details]
       

Editorial

Hill, EW; (2010) Livestock Issue. Editorial [DOI] [Details]
                                                                                                                             

Research

Research Interests

The aim of the research programme is to perform extensive and intensive phenotyping of end-point exercise physiological performance parameters and endophenotypes associated with muscular and mitochondrial function to test the hypothesis that genetic variation, catalogued using state-of-the-art genomic technologies, contributes to functional micro-adaptations that are influenced by exercise and cumulatively increase aerobic capacity.

Genetic variation is being assessed in a large cohort of Thoroughbred horses in training:

·         Illumina Equine SNP70 genotyping array

·         Affymetrix Equine SNP670 genotyping array
 

To project will test the hypotheses that genetic variation:

1)      contributes to variation in measured end-point physiological exercise parameters

2)      is reflected in variation in skeletal muscle gene expression

3)      underpins complex pathological phenotypes leading to poor-performance

4)      influences variation in mitochondrial function

Additional projects:
Genetic variation among indigenous Chinese horse populations
Genetics of behavioural traits in Thoroughbred horses

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Integrated genomics approaches to understanding genetic contributions to system-wide exercise physiology parameters in a large animal model.
Start Date / End Date : 01-APR-12 / 31-MAR-19

Recent Postgraduates

Jingjing Gu, PhD 2009
Beatrice McGivney, PhD 2009
Suzanne Eivers, PhD 2009
Mary Rooney, PhD 2016 
Charlotte McGivney, PhD 2017 
Gabriella Farries, PhD 2018 

Current Postgraduate Students

Amy Holtby, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Haige Han, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201700   ANSC30210     Animal Science: Equine Industries
201700   ANSC40090     Animal Science: Equine Science Project
201700   ANSC30250     Animal Science: Equine Genetics
       

Collaborators

Internal Collaborators

Associate Prof Lisa Katz, School of Veterinary Medicine
Prof David MacHugh, School of Agriculture and Food Science