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researcher

Emmeline Hill

College Lecturer

School Of Agriculture & Food Science
Veterinary Science Centre
Belfield
Dublin 4

Tel: +353 1 7166231
Email: emmeline.hill@ucd.ie

Biography

1998-1999: Research Associate, International Livestock Research Institute, Kenya
1995-1999: Ph.D., Trinity College Dublin
1999-2000: Research Consultant, FAO of the United Nations
2000-2001: Postdoctoral Researcher, Trinity College Dublin
2002-2004: Postdoctoral Researcher, University College Dublin
2004-2010: President of Ireland Young Researcher Award, Science Foundation Ireland (SFI)
2004: College Lecturer in Equine Science


Publications

     

Peer Reviewed Journals

Hill EW, Gu J, Eivers SS, Fonseca RG, McGivney BA, Govindarajan P, Orr N, Katz LM, MacHugh DE; (2010) 'A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses'. PLoS ONE, 5 (1):null-null. Available Online [DOI] [Details]
Eivers SS, McGivney BA, Fonseca RG, MacHugh DE, Menson K, Park SD, Rivero JLL, Taylor CT, Katz LM, Hill EW; (2010) 'Alterations in oxidative gene expression in equine skeletal muscle following exercise and training'. Physiological Genomics, 40 (2):83-93. Available Online [DOI] [Details]
Hill EW, McGivney BA, Gu J, Whiston R, MacHugh DE; (2010) 'A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses'. BMC Genomics, 11 (1):552-null. Available Online [DOI] [Details]
McGivney, B.A., McGettigan, P.A., Browne, J.A., Evans, A.C., Fonseca, R.G., Loftus, B.J., Lohan, A., MacHugh, D.E., Murphy, B.A., Katz, L. M., Hill, E.W.; (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 (null):398398-null. Available Online [DOI] [Details]
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, Ducro B, Van Arendonk JAM, MacHugh DE, Ennis S, Hill EW, Brama PAJ ; (2010) 'Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses'. Animal Genetics, 41 (suppl. 2):2-7. Available Online [DOI] [Details]
Fonseca, R.G., Kenny, D., Hill, E.W., Katz, L.M.; (2010) 'The association of various speed indices to training responses in Thoroughbred flat racehorses measured with a global positioning and heart rate monitoring system'. Equine Veterinary Journal Supplement, 42 (38):51-57. Available Online [DOI] [Details]
Hill, E.W., Eivers, S.S., McGivney, RG., Fonseca, GU. J., Smith, N.A., Browne, J.A., MacHugh, D.E., Katz, L.M.; (2010) 'Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle'. Equine Veterinary Journal Supplement, 42 (38):576-581. Available Online [DOI] [Details]
Martin, A.M., Elliott, J.A., Duffy, P., Blake, C., Attia, S.B., Browne, J.A., Katz, L.M., Gath, V., McGivney, B.A., Hill, E.W., Murphy, B.A. ; (2010) 'Circadian regulation of locomotor activity and skeletal muscle gene expression in the horse'. Journal of Applied Physiology, 109 (5):1328-1336. Available Online [DOI] [Details]
Bower MA, Whitten M, Nisbet RER, Spencer M, Dominy KM, Murphy AM, Cassidy R, Barrett E, Hill EW, Binns M.; (2010) 'Thoroughbred horse mitochondrial DNA demonstrates closer than expected links between maternal genetic history and pedigree records'. Equine Veterinary Journal, . [Details]
Gu J, MacHugh DE, McGivney BA, Park SDE, Katz LM, Hill EW; (2010) 'Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses'. Equine Veterinary Journal Supplement, 42 (38):569-575. Available Online [DOI] [Details]
Hill, E.W., Gu, J., McGivney, B.A., MacHugh, D.E.; (2010) 'Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance'. Animal Genetics, 41 (Suppl 2):56-63. Available Online [DOI] [Details]
Hill EW; (2010) 'Editorial, Livestock issue'. Briefings in Functional Genomics, 9 (3):191-192. [Details]
O'Gorman GM, Park SD, Hill EW, Meade KG, Coussens PM, Agaba M, Naessens J, Kemp SJ, Machugh DE; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. BMC Genomics, . [Details]
Gu J, Orr N, Park SD, Katz LM, Sulimova G, MacHugh DE, Hill EW; (2009) 'A genome scan for positive selection in thoroughbred horses'. PLoS ONE, 4 (6). Available Online [DOI] [Details]
McGivney BA, Eivers SS, MacHugh DE, MacLeod JN, O'Gorman GM, Park SD, Katz LM, Hill EW; (2009) 'Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy'. BMC Genomics, 10 . Available Online [DOI] [Details]
Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MC, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, Nergadze SG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE, Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Lander ES, Lindblad-Toh K.; (2009) 'Genome sequence, comparative analysis, and population genetics of the domestic horse'. Science, 326 (5954):865-867. [Details]
O'Gorman GM, Park SD, Hill EW, Meade KG, Coussens PM, Agaba M, Naessens J, Kemp SJ, MacHugh DE; (2009) 'Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility'. Genomics, 10 . [DOI] [Details]
Meade KG, O'Gorman GM, Hill EW, Narciandi F, Agaba M, Kemp SJ, O'Farrelly C, Machugh DE.; (2009) 'Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle'. Molecular immunology, . [Details]
McGahern AM, Edwards CJ, Bower MA, Heffernan A, Park SD, Brophy PO, Bradley DG, MacHugh DE, Hill EW; (2006) 'Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses'. Animal Genetics, 37 (5):498-502. [DOI] [Details]
McGahern A, Bower MA, Edwards CJ, Brophy PO, Sulimova G, Zakharov I, Vizuete-Forster M, Levine M, Li S, MacHugh DE, Hill EW; (2006) 'Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations'. Animal Genetics, 37 (5):494-497. [DOI] [Details]
O'Gorman GM, Park SD, Hill EW, Meade KG, Mitchell LC, Agaba M, Gibson JP, Hanotte O, Naessens J, Kemp SJ, MacHugh DE; (2006) 'Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense'. Genomics, 28 (1):53-61. [DOI] [Details]
Tozaki T, Sato F, Hill EW, Miyake T, Endo Y, Kakoi H, Gawahara H, Hirota K, Nakano Y, Nanbo Y, Kurosawa M; (2011) 'Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses'. The Open Veterinary Science Journal, null (Aug11):null-null. Available Online [DOI] [Details]
Hill EW, O'Gorman GM, Agaba M, Gibson JP, Hanotte O, Kemp SJ, Naessens J, Coussens PM, MacHugh DE; (2005) 'Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics'. Veterinary Immunology and Immunopathology, 105 (3-4):247-258. [DOI] [Details]
Eivers, S.S., McGivney, B.A., Gu J., MacHugh, D.E., Katz, L.M., Hill, E.W.; (2011) 'PGC-1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise'. Animal Genetics, . Available Online [DOI] [Details]
Meade KG, Hill EW, Buckley F, MacHugh DE ; (2005) 'Convenient detection of single nucleotide polymorphism haplotypes in the bovine growth hormone gene using amplification-created restriction sites'. Animal Genetics, 36 (2):175-177. [DOI] [Details]
Tozaki T, Hill EW, Hirota K, Kakoi H, Gawahara H, Miyake T, Sugita S, Hasegawa T, Ishida N, Nakano Y, Kurosawa M. ; (2011) 'A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18'. Animal Genetics, null (null):null-null. Available Online [DOI] [Details]
Hanotte O, Bradley DG, Ochieng JW, Verjee Y, Hill EW, Rege JE.; (2002) 'African pastoralism: genetic imprints of origins and migrations'. Science, 296 (5566):336-339. [Details]
Hill EW, Fonseca RG, McGivney BA, Gu J, MacHugh DE, Katz LM. ; (2012) 'MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses'. Journal of Applied Physiology, 112 (null):86-90. Available Online [DOI] [Details]
13. Bower M, Campana M, Whitten C, Edwards C, Jones H, Barrett E, Cassidy R, Nisbet RE, Hill EW, Howe C, Binns M.; (2010) 'The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish Native mares'. Biology Letters, Oct 6 (null):null-null. Available Online [DOI] [Details]
Hill E.W., Al Barody M., Bradley D.G., Ertugrul O., Splan R.K., Zakharov I. & Cunningham E.P.; (2002) 'History and integrity of thoroughbred dam lines revealed in equine mtDNA variation'. ANIMAL GENETICS, 33 :287-294. [Details]
Rosser Z.H., ['] Hill E.W., ['] & Jobling M.A.; (2002) 'Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1526-1543. [Details]
Richards M., ['] Hill E. W., ., ['] & Stefanescu G.; (2000) 'Tracing European founder lineages in the Near Eastern mtDNA pool'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :1251-1276. [Details]
Helgason A., ., ['], Hill E.W., ., ['] & Stefansson K.; (2000) 'Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland'. AMERICAN JOURNAL OF HUMAN GENETICS, 67 :697-717. [Details]
Hill E.W., Jobling, M.A. & Bradley, DG; (2000) 'Y chromosomes and Irish origins'. NATURE, 404 :351-352. [Details]
Achukwi M.D., Tanya, V.N., Hill, E.W., Bradley, D.G., Meghen, C., Sauveroche, B., Banser, J.T. & Ndoke, J.N.; (1997) 'Susceptibility of the Namchi and Kapsiki cattle of Cameroon to trypanosome infection'. TROPICAL ANIMAL HEALTH AND PRODUCTION, 29 :219-226. [Details]
                                                                                             

Research

Research Interests

The Equine Exercise Genomics Group uses functional and population genomic approaches to understand the genetic contributions to exercise adaptation and Thoroughbred athletic performance.

Current interests and research projects include:

 

1)  Genomic selection for exercise adaptation

 

 

2)  Genetic variation and racecourse performance

 

 

3)  Gene expression in skeletal muscle

 

 

4)  Genetic association studies using the Equine SNP50BeadChip

 

 

5)  Accurate phenotyping of exercise-relevant physiological traits for GWAS

 

 

     

Teaching

Teaching Philosophy

At the heart of my teaching is to develop real understanding, empowering students to critically evaluate and utilise science in equine management. There is no greater satisfaction to me as a teacher than to see the ¿eureka¿ moment in a student¿s face when the pieces of knowledge come together.

Modules Coordinated

201200   ANSC30250     Animal Science: Equine Genetics
201200   ANSC30210     Animal Science: Equine Industries
201200   ANSC40090     Animal Science: Equine Science Project