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| Dr. John Browne is
a senior technical officer in the School of Agriculture and Food Science in
UCD. He successfully completed his PhD studies in NUI Maynooth where he gained
a thorough understanding of the challenges of working with RNA and developed
expertise in a number of methods to identify differentially expressed
genes. After completing a postdoctoral fellowship
in clinical research he returned to animal science in UCD where he is responsible
for managing both the Transcriptomics and the Containment Level 3
Laboratories. He contributes directly to
a number of funded research projects and has extensive expertise in the use of qPCR
and next generation sequencing to study gene expression. He is actively
involved in promoting best practice for qPCR experiments through the MIQE
guidelines, and has received certified training in the management of
Containment Level 3 facilities. |
| Walsh SW, Mehta JP, McGettigan PA, Browne JA, Forde N, Alibrahim RM, Mulligan FJ, Loftus B, Crowe MA, Matthews D, Diskin M, Mihm M, Evans AC (2012) 'Effect of the metabolic environment at key stages of follicle development in cattle: focus on steroid biosynthesis'. Genomics, 44 (9):504-517. [DOI] [Details] |
| Machugh DE, Taraktsoglou M, Killick KE, Nalpas NC, Browne JA, Park SD, Hokamp K, Gormley E, Magee DA (2012) 'Pan-genomic analysis of bovine monocyte-derived macrophage gene expression in response to in vitro infection with Mycobacterium avium subspecies paratuberculosis'. Veterinary Research, 43 (1). [DOI] [Details] |
| Magee DA, Taraktsoglou M, Killick KE, Nalpas NC, Browne JA, Park SD, Conlon KM, Lynn DJ, Hokamp K, Gordon SV, Gormley E, MacHugh DE (2012) 'Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis'. PLoS ONE, 7 (2). [DOI] [Details] |
| Sheridan MP, Browne JA, MacHugh DE, Costello E, Gormley E (2012) 'Impact of delayed processing of bovine peripheral blood on differential gene expression'. VET IMMUNOL IMMUNOP, 145 (1-2):199-205. [DOI] [Details] |
| Devitt, E. J., Power, K. A., Lawless, M. W., Browne, J. A., Gaora, P. O., Gallagher, W. M., and Crowe, J. ; (2011) 'Early proteomic analysis may allow noninvasive identification of hepatitis C response to treatment with pegylated interferon α-2b and ribavirin'. European Journal of Gastroenterology & Hepatology, 23 (2):177-183. [Details] |
| Killick KE, Browne JA, Park SD, Magee DA, Martin I, Meade KG, Gordon SV, Gormley E, O'Farrelly C, Hokamp K, MacHugh DE (2011) 'Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes'. Genomics, 12 . [DOI] [Details] | |||||||||
Taraktsoglou, M., Szalabska, U., Magee, D.A., Browne, J.A., Sweeney, T., Gormley, E., MacHugh, D.E.; (2011) 'Transcriptional profiling of immune genes in bovine monocyte-derived macrophages exposed to bacterial antigens'. Veterinary Immunology and Immunopathology, 140 :130-139.  [DOI] [Details] |
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| Martin, A.M., Elliott, J.A., Duffy, P., Blake, C., Attia, S.B., Browne, J.A., Katz, L.M., Gath, V., McGivney, B.A., Hill, E.W., Murphy, B.A. ; (2010) 'Circadian regulation of locomotor activity and skeletal muscle gene expression in the horse'. Journal of Applied Physiology, 109 (5):1328-1336. [DOI] [Details] |
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| McGlynn, OF,Browne, JA,Blake, CM,Murphy, BA; (2010) 'Time of day influences cytokine and clock gene response to immune stimulation in equine whole blood'. Animal Genetics, 41 :202-204. [DOI] [Details] | |||||||||
| Devitt, E,Lawless, MW,Sadlier, D,Browne, JA,Walsh, C,Crowe, J; (2010) 'Early viral and peripheral blood mononuclear cell responses to pegylated interferon and ribavirin treatment: the first 24 h'. European Journal of Gastroenterology & Hepatology, 22 :1211-1220. [DOI] [Details] | |||||||||
| Hill, E.W., Eivers, S.S., McGivney, B.A., Fonseca, R.G., Gu, J., Smith, N.A., Browne, J.A., MacHugh, D.E., Katz, L.M.; (2010) 'Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle'. Equine Veterinary Journal, 42 :576-581576. [DOI] [Details] |
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| McGivney, BA,McGettigan, PA,Browne, JA,Evans, ACO,Fonseca, RG,Loftus, BJ,Lohan, A,MacHugh, DE,Murphy, BA,Katz, LM,Hill, EW; (2010) 'Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training'. BMC Genomics, 11 . [DOI] [Details] | |||||||||
| de Ross, B,Rungapamestry, V,Ross, K,Rucklidge, G,Reid, M,Duncan, G,Horgan, G,Toomey, S,Browne, J,Loscher, CE,Mills, KHG,Roche, HM; (2009) 'Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet'. Proteomics, 9 :3244-3256. [DOI] [Details] | |||||||||
| Machugh DE, Gormley E, Park SD, Browne JA, Taraktsoglou M, O'Farrelly C, Meade KG; (2009) 'Gene Expression Profiling of the Host Response to Mycobacterium bovis Infection in Cattle'. Transboundary and emerging diseases, . [DOI] [Details] |
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| Tyson, T, Reardon, W, Browne, JA, Burnell, AM, ; (2007) 'Gene induction by desiccation stress in the entomopathogenic nematode Steinernema carpocapsae reveals parallels with drought tolerance mechanisms in plants'. International Journal for Parasitology, 37 :763-776. [Details] | |||||||||
| Burnell AM, Shannon AJ, Browne JA, Boyd J, Fitzpatrick DA, ; (2005) 'The anhydrobiotic potential and molecular phylogenetics of species and strains of Panagrolaimus (Nematoda, Panagrolaimidae)'. Experimental Biology, 208 (Pt 12):2433-2445. [DOI] [Details] | |||||||||
| Tunnacliffe A, Goyal K, Browne JA, Burnell AM, ; (2005) 'Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins'. Biochimie, 87 (6):565-574. [DOI] [Details] | |||||||||
| De Roos B, Rucklidge G, Reid M, Pickard K, Navarro MA, Arbones-Mainar JM, Guzman-Garcia MA, Osada J, Browne J, Loscher CE & Roche HM.; (2005) 'Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach'. Faseb Journal, 19 :1746-1748. [Details] | |||||||||
| Roche HM, de Roos B, Rucklidge G, Reid M, Ross K, Duncan G, Navarro MA, Arbones-Mainar JM, Guzman-Garcia MA, Osada J, Browne J, Loscher CE, ; (2005) 'Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach'. FASEB Journal, 19 (12):1746-1748. [DOI] [Details] | |||||||||
| Goyal K, Walton LJ, Browne JA, Burnell AM, Tunnacliffe A; (2005) 'Molecular anhydrobiology: Identifying molecules implicated in invertebrate anhydrobiosis'. INTEGRATIVE AND COMPARATIVE BIOLOGY, 45 :702-709. [Details] | |||||||||
| Browne JA, Dolan KM, Tyson T, Goyal K, Tunnacliffe A,Burnell AM, ; (2004) 'Dehydration-specific induction of hydrophilic protein genes in the anhydrobiotic nematode Aphelenchus avenae'. Eukaryotic Cell, 3 (4):966-975. [DOI] [Details] | |||||||||
| Tunnacliffe A, Goyal K, Tisi L, Basran A, Browne J, Burnell A, Zurdo J, ; (2003) 'Transition from natively unfolded to folded state induced by desiccation in an anhydrobiotic nematode protein'. Journal of Biological Chemistry, 278 (15):12977-12984. [DOI] [Details] | |||||||||
| Browne J, Tunnacliffe A,Burnell A, ; (2002) 'Anhydrobiosis: plant desiccation gene found in a nematode'. Nature, 416 (6876). [DOI] [Details] | |||||||||
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| Hill EW, Eivers SS, McGivney BA, Fonseca RG, Gu J, Smith N, Browne J, MacHugh DE, Katz LM; (2010) Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle 8th International Conference on Equine Exercise Physiology [Details] |
