Researchers at UCD


Colm Ryan

Research Scholarships

Alumni Development



Colm J. Ryan is the ICON Newman Fellow in Genomics. He is interested in understanding how network context may be used to understand the connection between genotype and phenotype. During his PhD he studied large scale genetic-interaction networks in yeast and currently he is applying related ideas to the analysis of complex disease.



Book Chapters

Pedro Beltrao, Colm Ryan, Nevan J. Krogan (2012) 'Comparative Interaction Networks: Bridging Genotype to Phenotype' In: Pedro Beltrao, Colm Ryan, Nevan J. Krogan (eds). Evolutionary Systems Biology, Advances in Experimental Medicine and Biology. Springer: Springer. [Details]
Ryan C, Cagney G, Krogan NJ, Cunningham P, Greene D (2011) ''Imputing and predicting quantitative genetic interactions in epistatic MAPs' In: Ryan C, Cagney G, Krogan NJ, Cunningham P, Greene D (eds). Network Biology: Methods and Applications (Methods in Molecular Biology). USA: Springer Verlag. , pp.353-361 Available Online [DOI] [Details]

Peer Reviewed Journals

Ryan CJ, Krogan NJ, Cunningham P, Cagney G (2013) 'All or Nothing: Protein Complexes Flip Essentiality between Distantly Related Eukaryotes'. Genome Biology and Evolution, 5 (6):1049-1059. [DOI] Link to full text [Details]
Haber JE, Braberg H, Wu Q, Alexander R, Haase J, Ryan C, Lipkin-Moore Z, Franks-Skiba KE, Johnson T, Shales M, Lenstra TL, Holstege FC, Johnson JR, Bloom K, Krogan NJ (2013) 'Systematic Triple-Mutant Analysis Uncovers Functional Connectivity between Pathways Involved in Chromosome Regulation'. Cell reports, . [DOI] Link to full text [Details]
Ryan CJ, CimermanĿiĿ P, Szpiech ZA, Sali A, Hernandez RD, Krogan NJ (2013) 'High-resolution network biology: connecting sequence with function'. Nature reviews. Genetics, 14 (12):865-879. [DOI] [Details]
Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM (2013) 'Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae'. Cell reports, 5 (6):1725-1736. [DOI] [Details]
Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ (2012) 'Hierarchical Modularity and the Evolution of Genetic Interactomes across Species'. Molecular cell, 46 (5):691-704. [DOI] Link to full text [Details]
Moehle, EA,Ryan, CJ,Krogan, NJ,Kress, TL,Guthrie, C (2012) 'The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing'. PLoS Genetics, 8 . [DOI] [Details]
Wang, AY,Aristizabal, MJ,Ryan, C,Krogan, NJ,Kobor, MS; (2011) 'Key Functional Regions in the Histone Variant H2A.Z C-Terminal Docking Domain'. Molecular and Cellular Biology, 31 :3871-3884. [DOI] [Details]
Ryan, C,Greene, D,Guenole, A,van Attikum, H,Krogan, NJ,Cunningham, P,Cagney, G; (2011) 'Improved functional overview of protein complexes using inferred epistatic relationships'. BMC systems biology, 5 . [DOI] [Details]
Ryan C, Cagney G, Krogan N, Cunningham P, Greene D (2011) 'Imputing and predicting quantitative genetic interactions in epistatic MAPs'. Methods, 781 :353-361. [DOI] [Details]
Ryan, C., Greene, D., Cagney, G., Cunningham, P.; (2010) 'Missing value imputation for epistatic MAPs'. BMC Bioinformatics, 11 . Available Online [DOI] [Details]