Navigation

Researchers at UCD

researcher

Paul McCabe

Associate Professor

School Of Biology & Environment Science
Science Centre
Belfield
Dublin 4

Tel: +353 1 7162251
Email: paul.mccabe@ucd.ie

Biography

I obtained my B.Sc and Ph.D from NUI Maynooth. My Ph.D was undertaken under the supervision of Prof. Philip Dix and I studied chloroplasts genetics.

I was sucessful in obtaining a one year UNESCO research fellowship at the Biological Research Centre in Szeged, Hungary and worked with Dr. Peter Medgyesy.

I spent 2 years in the laboratory of Prof. Ken Sink at Michigan State University, USA, as a Postdoctoral Fellow and studied asymmetic protoplast fusion.

I  spent 3 years in the laboratory of Dr. Roger Pennell at University College London, as a Postdoctoral Fellow and investigated the role of arabinogalactan proteins during somatic embryogenesis

I spent 3 years in the laboratory of Prof. Christopher Leaver, FRS, at Oxford University as a Senior Postdoctoral Fellow and investigated the regulation of programmed cell death in plants. 

I was appointed to my present position in UCD in Sept 2000

Professional

Honours and Awards

Year: 1988.
Title: UNESCO international research fellowship
       

Conference Contributions

Paul McCabe; (2009) Hallmark features of apoptotic-like PCD: Cell morphology and mitochondrial involvement. [Invited Lecture], 20th International Conference on Arabidopisis Research, Edinburgh, Scotland , 30-JUN-09 - 04-JUL-09.
Paul McCabe; (2009) Co-organiser of Workshop on cell death in plants. [Other], 20th International Conference on Arabidopisis Research, Edinburgh, Scotland , 30-JUN-09 - 04-JUL-09.
Paul McCabe; (2009) Evolution of PCD. [Invited Lecture], Leopoldina Symposium on Evolution of Programmed Cell Death in Infection and Immunity, Wurzburg, Germany , 18-SEP-09 - 20-SEP-09.
Paul McCabe; (2007) Society for Experimental Biology. [Chaired Session], Regulation of programmed cell death in plants, Glasgow , 31-MAR-07 - 04-APR-07.
Paul McCabe; (2007) FEBS Advanced Course: Mitochondria in Life , Death and Disease. [Invited Lecture], FEBS Advanced Course: Mitochondria in Life , Death and Disease, Aussios, France , 22-APR-07 - 29-APR-07.
Paul McCabe; (2007) 8th International Congress on Plant Mitochondrial Molecular Biology. [Invited Lecture], 8th International Congress on Plant Mitochondrial Molecular Biology, Nara, Japan , 01-JUL-07 - 06-JUL-07.
Paul McCabe; (2008) 18th New Phytologist Symposium: Calcium-based Signalling Systems in Plants. [Invited Lecture], 18th New Phytologist Symposium: Calcium-based Signalling Systems in Plants, Dublin, Ireland , 04-DEC-08 - 06-DEC-08.
Paul McCabe; (2007) Society for Experimental Biology. [Invited Lecture], Society for experimental biology, Glasgow , 30-MAR-07 - 04-APR-07.
Paul McCabe; (2005) 13th New Phytologist Symposium: 'The role of the extracellular matrix in the control of plant development'. [Invited Lecture], 13th New Phytologist Symposium: 'The role of the extracellular matrix in the control of plant development', London , 18-JAN-05 - 21-JAN-05.
Paul McCabe; (2002) CNRS conference. [Invited Lecture], Jacques Monod CNRS Conference 'Cell Death Across Kingdoms', France , 12-MAY-02 - 15-MAY-02.

Committees

Committee : SFI UREKA advisory committee
Committee : Teagasc/UCD Stategy subcommittee
Committee : School Teaching and Learning committee
Committee : Science District project subcommittee: Space Usage for Teaching and Learning
Committee : Open Day/Schools Liason Committee
Committee : Biosciences teaching curriculum committee
 

Education

Year 1990 Institution: NUI Maynooth, IRL
Qualification: PhD Subject:
Year 1984 Institution: NUI Maynooth, IRL
Qualification: BSc Subject:
         

Publications

 

Book Chapters

Reape, T.J. and McCabe, P.F. (2015) 'Balancing Life and Death: The Role of the Mitochondrion in Programmed Cell Death' In: Taiz, L., Zeiger, E., Moller, I.M., Murphy, A (eds). Plant Physiology and Development. MA, USA: Sinauer. Available Online [Details]
McCabe, P. (2017) 'Senesence in Plants' In: eLS (eds). Encyclopedia of Life Science. Chichester: John Wiley and Sons. [DOI] [Details]
Kacprzyk, J., Dauphinee, A.N., Gallois, P, Gunwardena, A.H.L.A.N., and P.F. McCabe (2016) 'Plant programmed cell death methods' In: Puthalakath, Hamsa and Hawkins, Christine J (eds). Methods in Molecular Biology, Programmed cell death ¿ Methods and Protocol¿s Vol. 1419. New York: Springer Press. , pp.145-160 [Details]
Hunt, D.J.L. and P.F. McCabe (2016) 'Death precedes birth: programmed cell death during plant sexual reproduction' In: Ray Rose (eds). Molecular Cell Biology of the Growth and Differentiation of Plant Cells. Florida, USA: CRC press. , pp.340-361 [DOI] [Details]
Reape, T.J., Brogan, N. P. and P.F. McCabe. (2015) 'Mitochondrion and chloroplast regulation of plant programmed cell death' In: A. N. Gunwardena and P. F. McCabe (eds). Plant Progammed Cell Death. Switzerland: Springer. , pp.33-53 [DOI] [Details]
Reape, T.J., Kacprzyk, J., Brogan N., Sweetlove, L. and P.F. McCabe. (2015) 'Mitochondrial markers of programmed cell death' In: J. Whelan and M. W. Murcha (eds). Methods in Molecular Biology, Plant Mitochondria: Methods and Protocols Vol. 1305. New York: Springer Press. , pp.211-221 Available Online [DOI] [Details]
Kacprzyk, J. and P.F. McCabe (2015) 'A root hair assay to expedite cell death research' In: J. Estevez (eds). Methods in Molecular Biology, Plant cell growth and expansion - Methods and Protocol's, Vol. 1242. New York: Springer Press. , pp.73-82 [DOI] [Details]
Kacprzyk, J., Daly, C.T. and McCabe, P.F. (2011) 'The Botanical Dance of Death: Programmed cell death in plants' In: Kader, J-C. and Delseny, M (eds). Advances in Botanical Research. Vol. 60. UK: ABR, UK: Academic Press. , pp.169-261 [DOI] [Details]
Diamond, M. and McCabe, P.F.; (2011) 'Mitochondrial regulation of plant programmed cell death' In: Frank Kempken (eds). Plant Mitochondria, Advances in Plant Biology 1. Verlag: Springer Publishing. , pp.439-465 [DOI] [Details]
Reape, T. and McCabe, P.F.; (2010) 'Balancing life and death: The role of the mitochondrion in programmed cell death' In: Lincoln Taiz and Eduardo Zeiger (eds). Plant Physiology Online Fifth Edition. Massachusetts, USA: Sinauer Associates. Available Online [Details]
Diamond, M. and P.F McCabe ; (2007) 'The mitochondrion and plant programmed cell death' In: D.C. Logan (eds). Annual Plant Reviews; Plant Mitochondria. Oxford: Blackwell publishing. , pp.308-329 [Details]
Dix PJ, Burbridge E, Rassmussen SK, McCabe PF; (2003) 'Expression of cereal peroxidase and oxalate oxidase genes in tobacco results in alterations in plant development and programmed cell death' In: Vasil IK (eds). Plant Biotechnology 2002 and beyond. Dordrecht, Netherlands: Kluwer Academic Publishers. , pp.193-196 [Details]
Paul F. McCabe and Roger I. Pennell; (1996) 'Apoptosis in plant cells in vitro' In: (eds T.G. Cotter and S.J. Martin) Portland Press, London (eds). Techniques In Apoptosis: A User's Guide. , pp.301-326 [Details]
Paul F. McCabe, Agnes Cséplö, Aileen M. Timmons and Philip J. Dix; (1990) 'Selection of Chloroplast Mutants' In: (eds. J.W. Pollard and J.M. Walker) The Humana Press (eds). Methods in Molecular Biology, vol.6, Plant Cell and Tissue Culture. , pp.467-475 [Details]
P.J. Dix, C.P. McKinley and P.F. McCabe; (1990) 'Antibiotic Resistant Mutants of Solanum nigrum' In: eds. H.J.J Nijkamp, L.H.W. van der Plas and J. van Aartrijk. Kluwer Academic Publishers, Dordrecht (eds). Progress in Plant Cellular and Molecular Biology. , pp.169-173 [Details]

Edited Books

Gunwardena, A. N. and P.F. McCabe (Ed.). (2015) Plant Programmed Cell Death. New York: Springer. [DOI] [Details]

Peer Reviewed Journals

Joanna Kacprzyk, Niall P. Brogan, Cara T. Daly, Siamsa M. Doyle, Mark Diamond, Elizabeth M. Molony, Paul F. McCabe (2017) 'The retraction of the protoplast during PCD is an active, and interruptible, calcium-flux driven process'. Plant Science, 260 :50-59. Available Online [DOI] [Details]
Burbridge, E., Rasmussen, S.K., Bernier, F., Kristensen, B.K., McCabe, P.F., and P. J. Dix (2014) 'Altered activity of peroxidase and oxalate oxidase influences lignification'. The Open Plant Science Journal, 8 :1-8. [DOI] [Details]
Kacprzyk, J., Devine, A. and P.F. McCabe (2014) 'The root hair assay facilitates the use of genetic and pharmacological tools in order to dissect multiple signalling pathways that lead to programmed cell death'. PLoS ONE, 9 :e94898. [DOI] [Details]
Gutiérrez, J., González-Pérez, S., García-García, F., Lorenzo, O., Revuelta, J.L., Daly C.T., McCabe, P.F., J.B. Arellano (2014) 'Programmed cell death activated by Rose Bengal in Arabidopsis thaliana cell suspension cultures requires functional chloroplasts'. Journal of Experimental Botany, 65 :3081-3095. [DOI] [Details]
Ansari, KI; Doyle, SM; Kacprzyk, J; Khan, MR; Walter, S; Brennan, JM; Arunachalam, CS; McCabe, PF; Doohan, FM (2014) 'Light influences how the fungal toxin deoxynivalenol affects plant cell death and defense responses'. Toxins, 6 :679-692. Link to full text [Details]
Hunt D, Chambers JP, Behpouri A, Kelly SP, Whelan L, Pietrzykowska M, Downey F, McCabe PF, Ng CKY (2014) 'Brachypodium distachyon cell suspension cultures: establishment and utilisation'. Cereal Research Communications, 42 :58-69. [DOI] [Details]
McCabe, PF (2013) 'Healing and closure following death: death signals from a wounded leaf'. New Phytologist, 200 (3):590-591. Available Online [DOI] [Details]
Diamond, M; Reape, TJ; Rocha, O; Doyle, SM; Kacprzyk, J; Doohan, FM; McCabe PF (2013) 'The Fusarium Mycotoxin Deoxynivalenol Can Inhibit Plant Apoptosis-Like Programmed Cell Death'. PLoS ONE, 8 (7 e69542):e69542. Available Online [DOI] Link to full text [Details]
Theresa J. Reape, Paul F. McCabe (2013) 'The cellular condensation of dying plant cells: Programmed retraction or necrotic collapse?'. Plant Science, 207 :135-139. Available Online [DOI] [Details]
Hogg, B.V., Molony, E.M., Kacprzyk, J., O'Reilly, C., Gallagher, T.F., Gallois, P. and McCabe, P.F. (2011) 'An in vivo root hair assay for determining rates of apoptotic-like programmed cell death in plants'. Plant Methods, 7:45 . Available Online [DOI] [Details]
Alden, K.P., Dhont-Cordelier, S., McDonald, K.L., Reape, T.J., Ng, C.K.Y., McCabe, P.F. and Leaver, C.J.; (2011) 'Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants'. Biochemical and Biophysical Research Communications, 410 (3):574-580. [DOI] [Details]
Reape, T.J. and McCabe, P.F.; (2010) 'Apoptotic-like regulation of programmed cell death in plants'. Apoptosis, 15 (3):249-256. [Details]
Doyle, S.M. and P.F. McCabe ; (2010) 'Type and cellular location of reactive oxygen species determine activation or suppression of programmed cell death in Arabidopsis suspension cultures'. Plant Signaling and Behaviour, 5 (4):467-468. Available Online [DOI] [Details]
Doyle, S.M., Diamond, M. and McCabe, P.F.; (2010) 'Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension cultures'. Journal of Experimental Botany, 61 (2):473-482. Available Online [DOI] [Details]
Reape, T.J. and McCabe, P.F.; (2008) 'Apoptotic-like programmed cell death in plants'. New Phytologist, 180 :13-26. [Details]
Reape, T.J., Molony, E.M. and McCabe, P.F.; (2008) 'Programmed cell death in plants: distinguishing between different modes'. Journal of Experimental Botany, 59 (3):435-444. [DOI] [Details]
Burbridge, E, Diamond, M, Dix, PJ, McCabe, PF, ; (2007) 'Use of cell morphology to evaluate the effect of a peroxidase gene on cell death induction thresholds in tobacco'. Plant Science, 172 :852-860. [Details]
Doyle, S, McCabe, P, ; (2007) 'Can chloroplasts regulate plant programmed cell death?'. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 146 :202-203. [Details]
McCabe, P, ; (2007) 'An in vitro model system to study PCD regulation in plants'. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 146 :201-201. [Details]
Burbridge, E; Diamond, M; Dix, PJ; McCabe, PF; ; (2006) 'Use of cell morphology to evaluate the effect of a peroxidase gene on cell death induction thresholds in tobacco'. Plant Science, 171 (1):139-146. [Details]
Matthews D.J., Moran B.M., McCabe P.F. & Otte M.L.; (2004) 'Zinc tolerance, uptake, accumulation and distribution in plants and protoplasts of five European populations of the wetland grass Glyceria fluitans'. Aquatic Botany, 80 :39-52. [Details]
Balk, J., Chew S.K., Leaver, C.J. and P.F. McCabe; (2003) 'The intermembrane space of plant mitochondria contains a DNase activity that may be involved in programmed cell death'. Plant Journal, 34 :573-583. [Details]
V. Delorme, P.F. McCabe, D.J. Kim and C.J. Leaver; (2000) 'A matrix metalloproteinase is expressed at the boundary of senescence and programmed cell death in cucumber'. Plant Physiology, 123 :917-927. [Details]
McCabe, PF, Leaver, CJ, ; (2000) 'Programmed cell death in cell cultures'. PLANT MOLECULAR BIOLOGY, 44 (3):359-368. [Details]
Janneke Balk, Christopher J. Leaver and Paul F. McCabe.; (1999) 'Translocation of cytochrome c from the mitochondria to the cytosol occurs during heat-induced programmed cell death in cucumber plants'. FEBS Letters, 463 :151-154. [Details]
Paul F. McCabe, Alex Levine, Per-Johan Meijer, Nicolas A. Tapon and Roger I. Pennell; (1997) 'A programmed cell death pathway activated in carrot cells cultured at low cell density'. Plant Journal, 12 :267-280. [Details]
P. Kjellbom, L. Snogerup, C. Stöhr, Christophe Reuzeau, P.F. McCabe, and R.I. Pennell.; (1997) 'Oxidative cross-linking of plasma membrane arabinogalactan proteins'. Plant Journal, 12 :1189-1196. [Details]
P.F. McCabe, T.A. Valentine, L.S. Forsberg, and R.I. Pennell.; (1997) 'Soluble signals from cells identified at the cell wall establish a developmental pathway in carrot'. Plant Cell, 9 :2225-2241. [Details]
Roger I. Pennell, Quentin C.B. Cronk, L. Scott Forsberg, Christine Stöhr, Lars Snogerup, Per Kjellbom and Paul F. McCabe; (1995) 'Cell-context signalling'. Proceedings of the Royal Society of London B: Biological Sciences, 350 :87-93. [Details]
Tony A. Kavanagh, Killian M. O'Driscoll, Paul F. McCabe and Philip J. Dix; (1994) 'Mutations conferring lincomycin, spectinomycin, and streptomycin resistance in Solanum nigrum are located in three different chloroplast genes'. Molecular and General Genetics, 242 :675-680. [Details]
P.F. McCabe, L.J. Dunbar, A. Guri and K.C. Sink; (1993) 'T-DNA tagged chromosome 12 in donor Lycopersicon esculentum X L.pennellii is retained in asymmetric somatic hybrids with recipient Solanum lycopersicoides'. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 86 :377-382. [Details]
P. F. McCabe, A.M. Timmons and P.J. Dix; (1989) 'A simple procedure for the isolation of streptomycin resistant plants in Solanaceae'. Molecular and General Genetics, 216 :132-137. [Details]

Other Journals

McCabe, P.F.; (2008) 'Regulation of programmed cell death' Agricell Reports 50 (3) :18. [Details]
Milbourne, D., Spink, J., Barth, S., Mullins, E., Griffin, D., Wall, D., Carroll, J., Doohan, F., Ng, C., McCabe, P.F., Feechan, A., Spillane, C., Sulpice, R., Wellmer, F., Graciet, E. (2015) 'A virtual centre for crop improvement: Boosting plant breeding to secure agicultural productivity in Ireland' Teagasc Research 10 (1) :26-27. [Details]
                                                                                                                                         

Research

Research Interests

Regulation of programmed cell death in plants. Currently: role of calcium, sphingolipids, fungal mycotoxins in control of plant programmed cell death

Role of cell-cell signalling molecules in controlling plant embryogenesis

Research Projects

Sponsor : Irish Research Council (IRC)
Title : Role of AGPs in directing developmental decisions in cultured cells
Start Date / End Date : 01-OCT-12 / 30-SEP-15
Sponsor : Science Foundation Ireland (SFI)
Title : Innovative mutagenesis breeding approach to produce novel high value horticultural cultivars
Start Date / End Date : 01-JAN-12 / 31-DEC-12
Sponsor : University College Dublin (UCD)
Title : A novel approach towards elucidation of the role of mitochondria in regulating plant programmed cell death
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Isolation and characterization of programmed cell death mutant in Arabidopsis thaliana
Start Date / End Date : 01-OCT-09 / 30-SEP-12
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Does the composition of the sphingolipidome determine survival in plant cells?
Start Date / End Date : 01-OCT-09 / 30-SEP-12

Recent Postgraduates

Mark Diamond PhD competed 2006

Keith Alden PhD completed 2008 (co-supervisor Dr Carl Ng)

Elizabeth Molony PhD completed 2009

Kate O'Gorman MSc competed 2009 (co-supervisor Prof. Derek Mitchell)

Siamsa Doyle PhD completed 2010
 
Joanna Kacprzyk PhD completed 2012 
 
Cara Daly PhD completed 2013 

 

Teaching

Teaching Philosophy

I teach courses in plant biotechnology, genetics and programmed cell  death in plant cells