The Integrative Biology Laboratory or
¿R¿ Lab is a pluri-disciplinary laboratory focusing on the functions of
epithelia. We use physics, chemistry, engineering, molecular and cellular
techniques to study secretory pathways. We combine an evolutionary approach
from Planctomycetes to Human to new biophysical and optical methods ranging
from cell ¿morphing¿ to Light Sheet Microscopy for 3D imaging.
Our ultimate goal is to
achieve a continuum of knowledge from single bacteria excretion capacity to
complex tissue secretion ability in an organism context. For example, we currently
studide epithelia functions at the molecular level within artificial
epithelial tissues (lung, kidney, gut¿) to create optimal conditions for cell
biology and molecular approaches as well as drug screening on specifically
targeted functions: protein expressing defect (cystic fibrosis, lung), water
retention (kidney diseases), tumor formation (Epithelial Mesenchymal Transition
EMT, metastasis..) or even infections.
We also provide advices and optical set-ups to research groups and collaborate extensively with the private sectors (Carl Zeiss MicroImaging GmbH, Aquamarine Power Ltd, Tech Works Ltd).
| Sponsor : Science Foundation Ireland (SFI) Title : Second Light Sheet Based Fluorescence Microscopy Workshop Start Date / End Date : 01-SEP-10 / 31-DEC-10 |
| Sponsor : The Cultural Service of the French Embassy Title : Tara Expedition Support Start Date / End Date : 01-NOV-09 / 01-APR-10 |
| Sponsor : University College Dublin (UCD) Title : Cellular architecture Start Date / End Date : 01-NOV-09 / 01-NOV-10 |
