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Cormac Declan Murphy

Associate Professor

School Of Biomolecular & Biomed Science
Science Centre - South
Belfield
Dublin 4

Tel: +353 1 7162572
Email: cormac.d.murphy@ucd.ie

Biography

1994 BSc Biochemistry (QUB)
1998 PhD Microbial Biochemistry (QUB)
1998-2001 Postdoctoral research at Dalhousie University, NS, Canada and St Andrews University, Scotland 
2001 Assistant Lecturer, Dept of Industrial Microbiology, UCD
2003 College Lecturer, School of Biomolecular and Biomedical Science, UCD
2011-2013 Vice Principal for Research and Innovation in the College of Science
2014 Senior Lecturer, School of Biomolecular and Biomedical Science, UCD

Research Links: Research in SBBS  |  Biotechnology Research in SBBS  |  Fluorine21 Initial Training Network


Cormac Murphy, Microbiology, IRCSET, EPA, Enterprise Ireland, Marie-Curie, Centre for Synthesis and Chemical Biology, Biotransformation, Fluorine, NMR 

Professional

Honours and Awards

Year: 2002.
Title: Institute of Chemical Engineers Judges' Award
Year: 2002.
Title: President's Research Award

Associations

Association: Society for General Microbiology, Function/Role: Member
Association: American Society for Microbiology, Function/Role: Member
Association: Royal Society of Chemistry, Function/Role: Fellow
Association: Society for General Microbiology, Function/Role: Member
Association: American Chemical Society, Function/Role: Member
     

Conference Contributions

Murphy, C; Moore, R; White R (1999) Peroxidases in marine microalgae. [Poster Presentation], Algae and human affairs in the 21st century, Montecatini Terme, Italy , 26-SEP-99 - 01-OCT-99.
Heffernan, B; Phelan, S; Murphy, C; Casey, E (2005) Investigation of the interactions between biological and physicochemical processes in a Pseudomonas fluorescens biofilm. [Poster Presentation], Advances in Synthesis and Chemical Biology IV, Dublin , 02-DEC-05 - 02-DEC-05.
Grant, R; Hutchinson, R; Murphy C (2007) Genetic characterisation and antibiotic production studies of Streptomyces viridogenes. [Poster Presentation], 107th General Meeting ASM, Toronto, Canada , 21-MAY-07 - 25-MAY-07.
Heffernan, B; Bryan, U; Murphy C; Casey, E (2007) Characteristics of planktonic and biofilm cultures of Pseudomonas fluorescens grown on 2-fluorobenzoate. [Poster Presentation], 107th General Meeting ASM, Toronto, Canada , 21-MAY-07 - 25-MAY-07.
Misiak, K; Murphy, C; Casey, C (2007) Biodegradation of fluorobenzoate using a Pseudomonas biofilm. [Poster Presentation], Conway Festival of Research, Dublin, Ireland , 20-SEP-07 - 20-SEP-07.
BR Clark, S Tennant, JH Gill, E Lacey, RJ Capon and CD Murphy ; (2008) Pyrrolylpolyenes from fungi: biosynthesis and analogue production. [Poster Presentation], 7th Joint Meeting of GA, AFERP, ASP, PSE and SIF, Athens, Greece , 03-AUG-08 - 08-AUG-08.
Clark, B; Fox, D; Murphy C (2009) Biosynthesis of polyenes in Auxarthron umbrinum. [Poster Presentation], Directing Biosynthesis, Durham, UK , 15-SEP-09 - 17-SEP-09.
Clark, B; Fox, D; Alnauman, A; O'Connor, S; Murphy, C (2009) Polyene biosynthesis in fungi and actinomycetes. [Poster Presentation], Advances in Chemical Biology, Dublin, Ireland , 18-DEC-09 - 18-DEC-09.
Robertson, K; Murphy, C; Paradisi, F (2010) A Novel Synthesis of Rare 4-methylenecyclohex-2-enone. [Poster Presentation], Advances in chemical biology IX, Dublin , 10-DEC-10 - 10-DEC-10.
Semião, A.J.C.; Habimana, O; Gazzola, G.; Heffernan, R.; Murphy, C.; Casey, E. (2012) The importance of laboratory water quality when studying initial bacterial adhesion during nanofiltration processes. [Poster Presentation], Euromembrane Conference 2012,, London , 23-SEP-12 - 27-SEP-12.
Quinn et al. (2014) Production of drug metabolites by immobilised Cunninghamella elegans. [Poster Presentation], Science and Solutions for a Sustainable Environment Conference, UCD , 11-DEC-14 - 12-DEC-14.
Saccomanno, M; O'Connor, N; Beier, P; Murphy CD (2015) Biotransformation of pentafluorosulphanyl aromatics. [Poster Presentation], RSC Fluorine Group Meeting, Durham, UK , 16-APR-15 - 17-APR-15.
BaAbbad, R; Czyzewska, M; Cobb, S; Murphy, C (2015) THE DEVELOPMENT OF 19F-NMR AS A TOOL FOR ANALYZING STEROID DEGRADATION IN ACTIVE URINE SAMPLES. [Poster Presentation], Recent Advances in Synthesis and Chemical Biology XIV, RCSI, Dublin , 11-DEC-15 - 11-DEC-15.
Kilty, C; Lopez-Noriega, A; Hurley, C; O'Connor, N; Reynolds, A; Murphy, C;O'Brien, F; Kennedy, B (2015) Sustained Release from Biodegradable Microparticles of Bioactive Cysteinyl Leukotriene Receptor Antagonists for the Treatment of Ocular Neovascularisation. [Poster Presentation], ARVO General Meeting, Denver, Colorado , 03-MAY-15 - 07-MAY-15.
Quinn, L; Li J; Murphy, CD (2015) Semi-continuous decolourization of malachite green by Cunninghamella elegans. [Poster Presentation], SGM Irish Branch Meeting, Galway, Ireland , 17-JUN-15 - 19-JUN-15.
Quinn, L and Murphy, C (2016) Factors affecting production of drug metabolites in Cunninghamella elegans. [Poster Presentation], 8th International Congress on Biocatalysis, Hamburg, Germany , 31-JUL-16 - 01-SEP-16.
Palmer-Brown, W. and Murphy, C. (2016) Biotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans. [Poster Presentation], 8th International Congress on Biocatalysis, Hamburg, Germany , 31-JUL-16 - 01-SEP-16.
Murphy, C (2016) Microbial biofilms and organofluorine compounds. [Invited Lecture], Fluorine as a key element, Berlin , 23-NOV-16 - 25-NOV-16.
Murphy, C (2017) Biofilms for organohalide biotransformations. [Invited Lecture], Biohalogenation, Strathclyde University, Scotland , 13-JUN-17 - 13-JUN-17.
Murphy, CD (2015) Fungal biofilms and organofluorine compounds. [Invited Lecture], 21st International Symposium on Fluorine Chemistry, Lake Como, Italy , 23-AUG-15 - 28-AUG-15.
Quinn et al. (2014) Fungal biofilm for biocatalysis. [Poster Presentation], Translational Biocatalysis, London, UK , 16-DEC-14 - 16-DEC-14.
Murphy, C (2014) Biocatalysis with filamentous fungal biofilms. [Oral Presentation], 7th International Congress on Biocatalysis, Hamburg, Germany , 31-AUG-14 - 04-SEP-14.
Murphy, CD (2013) Biofilm catalysed transformation of organofluorine compounds. [Invited Oral Presentation], 17th European Symposium on Fluorine Chemistry, Paris , 21-JUL-13 - 25-JUL-13.
Murphy, C (2013) [Conference Organising Committee Chairperson], Workshop on Catalytic Biofilms, University College Dublin , 13-NOV-13 - 13-NOV-13.
Phillips, AJ; Armstrong, D; Murphy, CD (2013) Synthesis, Characterisation and Biological Applications of Silver(I) Complexes Incorporating PTN(Me) (PTN = 7-Phospha-3-methyl-1,3,5-triazabicyclononane) and PTA (1, 3,5-Triaza-7-phosphatricyclodecane). [Oral Presentation], 6th Meeting of the Irish Institute of Metal-based Drugs, RCSI, Dublin , 01-NOV-13 - 01-NOV-13.
Winn, M; Casey, E; Murphy, CD (2013) Development of a Streptomyces griseus tubular biofilm reactor for the production of phase 1 drug metabolites. [Poster Presentation], Society for General Microbiology Irish Branch Meeting, Dublin , 21-MAR-13 - 22-MAR-13.
Czyzewska, M; Murphy, C; Cobb, S (2013) The development of 19F-NMR as a tool for analysing steroid degradation in active urine samples. [Poster Presentation], Joint RSC Fluorine and Carbohydrate Subject group Meeting, Southampton, UK , 02-SEP-13 - 03-SEP-13.
Murphy, CD (2012) Fluorinated drug metabolism in microorganisms. [Invited Oral Presentation], 243rd American Chemical Society National Meeting, San Diego, California , 25-MAR-12 - 29-MAR-12.
Clark, B and Murphy, C.D.; (2012) Biosynthesis of anticancer polyenes in Auxarthron umbrinum. [Poster Presentation (Refereed)], Zing Natural Products, Lanzarote, Spain , 10-FEB-12 - 13-FEB-12.
Robertson, K., Murphy, C. and Paradisi, F.; (2011) Towards the elucidation of the biosynthesis of chlorotetaine. [Poster Presentation], Recent Advances in Synthesis and Chemical Biology X, Dublin , 09-DEC-11 - 09-DEC-11.
O'Connor, N. and Murphy, C.; (2011) Production of fluorinated lipopeptides in Bacillus spp. [Poster Presentation], Recent Advances in Synthesis and Chemical Biology X, Dublin , 09-DEC-11 - 09-DEC-11.
Bright, T. et al.; (2011) Oxidation of drug metabolites by enzymes and directed selective fluorination. [Poster Presentation], Recent Advances in Synthesis and Chemical Biology X, Dublin , 09-DEC-11 - 09-DEC-11.
Sweeney, P., Murphy, C. and Caffrey, P.; (2011) Mining the genome of Streptomyces nodosus. [Poster Presentation], Recent Advances in Synthesis and Chemical Biology X, Dublin , 09-DEC-11 - 09-DEC-11.
Murphy, C; (2010) Institute de Reserches Servier Lecture. [Chaired Session], Recent Advances in Chemical Biology IX, Trinity College Dublin , 10-DEC-10 - 10-DEC-10.
Murphy, C; (2010) The Application of Fluorine-19 NMR to Probe the Interaction of Microorganisms and Organofluorine Xenobiotics. [Invited Lecture], 19 F spectroscopy (NMR and MRI) in chemical biology and biomedical imaging, Chatenay-Malabry, Paris , 25-NOV-10 - 25-NOV-10.
Moran, S; Clark, B; Murphy C (2010) Precursor-directed biosynthesis of fluorinated iturin A in Bacillus subtilis. [Poster Presentation], Directing Biosynthesis, Durham, UK , 15-SEP-10 - 17-SEP-10.
Amadio, J. and Murphy, C.D.; (2010) Microbial Models of Mammalian Metabolism: Biotransformation of Flurbiprofen by Cunninghamella elegans. [Poster Presentation], National Environmental Research Conference, Dublin, Ireland , 23-JUN-10 - 23-JUN-10.
Bright, T., Clark, B. and Murphy, C.; (2010) PRODUCTION OF MAMMALIAN DRUG METABOLITES BY STREPTOMYCES. [Poster Presentation], Advances in Chemical Biology IX, Trinity College Dublin , 10-DEC-10 - 10-DEC-10.
Murphy CD; (2009) Microbial biotransformation of fluorinated biphenyls. [Oral Presentation], BioMicroWorld2009 - 3rd International Conference on Environmental, Industrial and Applied Microbiology, Lisbon, Portugal , 02-DEC-09 - 04-DEC-09.
Murphy, C.; (2008) Probing the Interaction Between Fluorinated Compounds and Microorganisms Using 19F NMR. [Invited Oral Presentation], SMASH 2008, Santa Fe, New Mexico, USA , 08-SEP-08 - 11-SEP-08.
Misiak, K., Casey, E. and Murphy, C.; (2008) Biodegradation of fluorinated compounds in a Pseudomonas biofilm. [Poster Presentation], SGM Meeting, Trinity College Dublin , 08-SEP-08 - 11-SEP-08.
Moran, S., Rai, D. and Murphy, C.; (2008) Precursor-directed biosynthesis of fluorinated iturin A. [Poster Presentation], Recent Advances in Synthesis and Chemical Biology VII, UCD , 12-DEC-08 - 12-DEC-08.
Heffernan, H., Murphy, C. and Casey, E.; (2007) Investigation of the effect of 2-fluorobenzoate on respiratory location in a stratified Pseudomonas fluorescens biofilm. [Poster Presentation], 4th ASM Conference on Biofilms, Quebec City, Canada , 25-MAR-07 - 29-MAR-07.
Heffernan, B., Bryan, U., Murphy, C. and Csey, E.; (2007) General Meeting of the American Society for Microbiology. [Poster Presentation], 107th General Meeting of the American Society for Microbiology, Toronto, Canada , 21-MAY-07 - 25-MAY-07.
Naegel, L., Murphy, C. and Murillo-Alvarez, J.; (2007) Brominated compounds in egg capsules of the intertidal purple snail Plicopurpura pansa. [Poster Presentation (Refereed)], 40th Annual Meeting of the Western Society of Malacologists, Mexico , 25-JUL-07 - 28-JUL-07.
Murphy CD, Quirke S and Balogun O; (2007) Bacterial biodegradation of fluorobiphenyl. [Poster Presentation], Advances in Chemical Biology VI, Trinity College, Dublin , 14-DEC-07 - 14-DEC-07.
Balogun, O. and Murphy, C.; (2007) Bacterial biotransformation of 4-fluorobiphenyl. [Poster Presentation], SGM Irish Branch Meeting-Microbial Function in Response to the Environment, Belfast, UK , 30-AUG-07 - 31-AUG-07.
Misiak, K., Casey, E. and Murphy, C.; (2007) Biodegradation of fluorobenzoate using a Pseudomonas sp. B-13 biofilm. [Poster Presentation], SGM Irish Branch Meeting - Biofilms: A systems microbiology analysis, Limerick , 19-APR-07 - 20-APR-07.
Heffernan, H., Murphy, C. and Casey, E.; (2006) Degradation of fluorinated xenobiotics in a Pseudomonas fluorescens biofilm. [Poster Presentation], Biofilm Systems VI, Amsterdam , 24-SEP-06 - 27-SEP-06.
McGee, S. and Murphy, C.; (2006) Fluorophenol oxidation by a fungal chloroperoxidase. [Poster Presentation], Advances in Chemical Biology, Dublin, Ireland , 17-DEC-06 - 17-DEC-06.
Hutchinson, R., Grant, R. and Murphy, C.; (2006) The biochemistry of 4-amino-3-chloro-2-pentenedioic acid production in Streptomyces virdogenes. [Poster Presentation], Chemical Biology: Directing Biosynthesis, Cambridge, UK , 11-SEP-06 - 13-SEP-06.
Cormac Murphy; (2006) Microbial Bioconversions: Biocatalysis and Biodegradation. [Conference Organising Committee Chairperson], SGM Irish Branch Meeting, Dublin , 31-AUG-06 - 01-SEP-06.
Donnelly, C. and Murphy C.; (2005) Enzymatic defluorination of fluoroglutamate. [Poster Presentation], Biocatalysis: Enzymes, Mechanisms and Processes, Manchester, UK , 21-NOV-05 - 22-NOV-05.
Murphy, C.; (2003) Biocatalysis and Biodegradation. [Invited Oral Presentation], SGM Irish Branch Meeting, Dublin, Ireland , 04-SEP-03 - 05-SEP-03.
O'Hagan, D., Harper, D., Murphy, C. and Schaffrath, C.; (2001) Biosynthesis of 4-fluorothreonine in Streptomyces cattleya. [Refereed Abstracts], 222nd ACS National Meeting, Chicago, IL , 26-AUG-01 - 30-AUG-01.
Murphy, C., Schaffrath, C., Goss, R., Moss, S., Hamilton, J., Harper, D. and O'Hagan, D.; (2001) Studies on the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. [Poster Presentation], Naturally Produced Organohalogens, Heidleberg, Germany , 30-SEP-01 - 03-OCT-01.

Committees

Committee : School Research and Innovation Committee
Committee : School Teaching and Learning Committee
Committee : Science Timetable Committee
Committee : Graduate Taught Programme Board
Committee : School Postgraduate Committee
Committee : SBBS Quality Review Committee
Committee : SGM Irish Branch
Committee : College of Science Executive
Committee : Clique Governance Board
Committee : Academic Council Committee on Academic Centres
Committee : Academic Council

Employment

Employer: University College Dublin
Position: Lecturer
Employer: Dalhousie University, Canada
Position: Postdoctoral Fellow
Employer: St Andrews University, Scotland
Position: Postdoctoral Fellow

Education

Year 0 Institution: Queens University Belfast
Qualification: PhD Subject: --none--
Year 0 Institution: Queens University Belfast
Qualification: BSc Subject: --none--
Year 1998 Institution: Queen's University of Belfast, UK
Qualification: PhD Subject:
Year 1994 Institution: Queen's University of Belfast, UK
Qualification: BSc Subject:
 

Consultancy

Client: Irelandia Investments

Outreach Activities

University Open Days (2001-2011).  I have manned the Department of Industrial Microbiology/School of Biomolecular and Biomedical Science stand almost each year since joining UCD.
Secondary School visits:
 1. I visited Folye College, Derry, N.I. to give an overview of entrance requirements and procedures.
 2. I was invited to attend the prize night for St Colman's College, Newry, N.I.
In May 2014 I was a mentor at the EcoTech challenge at Dublin Castle for secondary school students.
I was interviewed for the 'Science Spinning' radio programme hosted by Sean Duke (http://sciencespin.podomatic.com/entry/2010-11-22T03_35_49-08_00)
Hosted students from seondary schools, post-leaving certificate college and other EU universities.  I have also placed students in my lab through the EU's Leonardo programme.

Journals Edited

Xenobiotica: Editorial Board member.
Rsc Advances: Reviewer.
Chemical Engineering Science: Reviewer.
Chemistry-A European Journal: Reviewer.
Journal Of Agricultural And Food Chemistry: Reviewer.
Environmental Microbiology: Reviewer.
Chemical Reviews: Reviewer.
Biotechnology Letters: Editorial Board member.
Applied And Environmental Microbiology: Reviewer.
Journal Of Fluorine Chemistry: Reviewer.
Enzyme And Microbial Technology: Reviewer.
Journal Of Applied Microbiology: Reviewer.
Water Research: Reviewer.
Metabolic Engineering : Reviewer.
Biotechnology Progress: Reviewer.
Biotechnology And Applied Biochemistry: Reviewer.
Plos One: Reviewer.
Journal Of Natural Products: Reviewer.
Molecular Biosystems : Reviewer.
Journal Of Molecular Catalysis B-Enzymatic: Reviewer.
Fems Microbiology Letters: Reviewer.
Microbial Ecology: Reviewer.
Current Organic Chemistry: Reviewer.
Bioorganic Chemistry: Reviewer.
Microbiology-Sgm: Reviewer.
Biotechnology And Bioengineering: Reviewer.
Organic And Biomolecular Chemistry: Reviewer.

Other Activities

Invited seminar Northumbria University, UK.  Fungal biofilm and organofluorine compounds.  March 20th 2015
Evaluator for Marie Curie Intra-European, International Incoming and International Outgoing Fellowships (October 2013). 
Referee for grant applications (Enterprise Ireland, BBSRC, American Chemical Society, Portuguese Foundation for Science and Technology, Czech Science Foundation, French National Research Agency, Research Corporation for Scientific Advancement, NSERC, Leverhulme Trust, European Society for Clinical Microbiology and infectious Deiseases).
 

External examiner for St Andrews University (PhD); Government College University, Faisalabad, Pakistan (PhD); the University of Aberdeen (MSc); Athlone Institute of Technology

Invited seminar in Durham University, UK.  Biosynthesis and biotransformation of organofluorine compounds (September 14th 2010)
Invited seminar at the Technical University of Dresden, Germany (July 9, 2009) Metabolism of fluoroorganic compounds in microorganisms.

Publications

 

Book Chapters

Murphy, C; Palmer-Brown, W; Quinn, L; Saccomanno, M (2017) 'Microbial metabolism of fluorinated drugs' In: Leroux, F; Haufe G (eds). Fluorine in Life Sciences. Pharmaceuticals, Medical Diagnostics and Agrochemicals. Amsterdam: Elsevier. [Details]
Murphy, C (2017) 'Chemicals Production: Biohalogenation' In: Lee, SY (eds). Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals. Heidelberg: Springer. [DOI] [Details]
Brennan, L., Mostaert, A.S., Murphy, C. and Owende, P. (2012) 'Phytochemicals from Algae' In: Carrier, J., Ramaswamy, S. and Bergeron, C (eds). Biorefinery Co-Products: Phytochemicals, Primary Metabolites and Value-Added Biomass Processing. Chichester, West Sussex, UK: John Wiley & Sons. , pp.199-240 Available Online [Details]
Murphy, C. and Clark, B.; (2013) 'Enzymatic halogenation in stereoselctive synthesis' In: Andrushko, V. and Andrushko, N (eds). Stereoselective synthesis of drugs and natural products. New York: Wiley-Blackwell. , pp.1377-1398 [Details]
Murphy, C.D. and Grant R.; (2010) 'Chemicals production - biohalogenation' In: Timmis KN (eds). Handbook of hydrocarbon and lipid microbiology. Heidelberg: Springer. , pp.2903-2910 Available Online [Details]
Murphy, C.; (2010) 'Halogenated Organic Compounds - Carbon-Halogen Bond Formation' In: Timmis KN (eds). Handbook of hydrocarbon and lipid microbiology. Heidelberg: Springer. , pp.376-381 Available Online [Details]
D.B. Harper, D. OHagan and C.D. Murphy.; (2003) 'Fluorinated natural products: occurrence and biosynthesis' In: Ed. G.W. Gribble (eds). Handbook of Environmental Chemistry. Berlin Heidelberg: Springer-Verlag. , pp.141-169 [DOI] [Details]
 

Peer Reviewed Journals

Hussain, S; Quinn, L; Li, J; Casey, E; Murphy, C (2017) 'Simultaneous removal of malachite green and hexavalent chromium by Cunninghamella elegans biofilm in a semi-continuous system'. International Biodeterioration and Biodegradation, . [Details]
Sweeney, J; Murphy, C; McDonnell, K (2017) 'Development of a bacterial propionate-biosensor for anaerobic digestion monitoring'. Enzyme and Microbial Technology, . [Details]
Sheehan, J; Murphy, C; Caffrey, P (2017) 'New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus'. Molecular BioSystems, 13 :866-873. [DOI] [Details]
Kealy,C; Creaven, C; Murphy, C; Brady, D (2017) 'New approaches to antibiotic discovery'. Biotechnology Letters, 39 :805-817. [DOI] [Details]
Korsand, F; Murphy, C; Whitehead, A; Engel, P (2017) 'Biocatalytic stereoinversion of D-para-bromophenylalanine in a one-pot three-enzyme reaction'. Green Chemistry (RSC journal), 19 :503-510. [DOI] [Details]
Palmer-Brown, W; Dunne, B; Ortin, Y; Fox, M; Sandford, G; Murphy, CD (2017) 'Biotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans'. Xenobiotica, 47 (9):763-770. [DOI] [Details]
Narancic, T; Scollica, E; Kenny, S; Gibbons, H; Carr, E; Brennan, L; Cagney, G; Wynne, K; Murphy, C; Raberg, M; Heinrich, D; Steinbüchel, A; O¿Connor, K (2016) 'Understanding the physiological roles of polyhydroxybutyrate (PHB) in Rhodospirillum rubrum S1 under aerobic chemoheterotrophic conditions'. Applied Microbiology and Biotechnology, 100 :8901-8912. [DOI] [Details]
Hampton, A; Mikulski, L; Palmer-Brown, W; Murphy, C; Sandford, G (2016) 'Evaluation of fluorinated biphenyl ether pro-drug scaffolds employing the chemical-microbial approach'. Bioorganic and Medicinal Chemistry Letters, 26 :255-258. [DOI] [Details]
Murphy, C (2016) 'Microbial degradation of fluorinated drugs: biochemical pathways, impacts on the environment and potential applications'. Applied Microbiology and Biotechnology, 100 :2617-2627. [DOI] Link to full text [Details]
Sweeney, P; Murphy, CD; Caffrey, P (2016) 'Exploiting the genome sequence of Streptomyces nodosus for enhanced antibiotic production'. Applied Microbiology and Biotechnology, 100 :1285-1295. [DOI] [Details]
Sweeney, J; Murphy, CD; McDonnell, K (2015) 'Towards an effective biosensor for monitoring AD leachate: a knockout E. coli mutant that cannot catabolise lactate'. Applied Microbiology and Biotechnology, 99 (23):10209-10214. [DOI] Link to full text [Details]
Murphy, C; Sandford, G (2015) 'Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity'. Expert Opinion on Drug Metabolism & Toxicology, 11 :589-599. [DOI] Link to full text [Details]
Quinn, L; Dempsey, R; Casey E; Kane , A; Murphy, C (2015) 'Production of drug metabolites by immobilised Cunninghamella elegans: from screening to scale-up'. Journal of Industrial Microbiology and Biotechnology, 42 :799-806. [DOI] Link to full text [Details]
Gazzola, G; Habimana, O; Murphy, C; Casey. E (2015) 'Comparison of biomass detachment from two different Pseudomonas spp. biofilms under constant shear conditions'. Biofouling, 31 (1):13-18. [DOI] Link to full text [Details]
O'Connor,N; Hudson, A; Cobb, S; O'Neil, D; Robertson, J; Duncan V; Murphy, C (2014) 'Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis'. Amino Acids, 46 :2745-2752. [DOI] Link to full text [Details]
Murphy, C (2015) 'Drug metabolism in microorganisms'. Biotechnology Letters, 37 :19-28. [DOI] Link to full text [Details]
Winn, M; Habimana, O; Casey, E; Murphy, C (2014) 'Characterisitics of Streptomyces griseus biofilms in continuous flow tubular reactors'. FEMS MICROBIOL LETT, 352 :157-164. [DOI] Link to full text [Details]
Shaughnessy, M; Harsanyi, H; Li, J; Bright, T; Murphy, C; Sandford, G. (2014) 'Targeted fluorination of a non-steroidal anti-inflammatory drug to prolong metabolic half-life'. Chemmedchem, 9 :733-736. [DOI] Link to full text [Details]
Kavanagh, E; Winn, M; NicGabhann, C; O'Connor, NK; Beier, P; Murphy CD (2014) 'Microbial biotransformation of aryl sulfanylpentafluorides'. Environmental Science and Pollution Research, 21 :753-758. [DOI] Link to full text [Details]
Robertson, K; Murphy, CD; Paradisi, F (2013) 'The Synthesis and Biological Testing of Bacilysin Analogues'. Amino Acids, 45 (5):1157-1168. [DOI] [Details]
Murphy, CD; Casey,E (2013) 'Biofilm-catalysed transformation of organofluorine compounds'. Chimica Oggi-Chemistry Today, 31 (3):6-10. [Details]
Amadio, J; Casey, E; Murphy, CD (2013) 'Filamentous fungal biofilm for production of human drug metabolites'. Applied Microbiology and Biotechnology, 97 (13):5955-5963. [DOI] Link to full text [Details]
Bright, T; Dalton,F; Elder, VL; Murphy, CD; O'Connor, NK; Sandford, G (2013) 'A convenient chemical-microbial method for developing fluorinated pharmaceuticals'. Organic and Biomolecular Chemistry, 11 (7):1135-1142. [DOI] Link to full text [Details]
O'Connor NK, Rai DK, Clark BR, Murphy CD (2012) 'Production of the Novel Lipopeptide Antibiotic Trifluorosurfactin via Precursor-Directed Biosynthesis'. Journal of Fluorine Chemistry, 143 :210-215. [DOI] Link to full text [Details]
Murphy CD and Sandford G (2012) 'Fluorinated drug metabolism in microorganisms'. Chimica Oggi-Chemistry Today, 30 (3):16-19. [Details]
Murphy C (2012) 'The Microbial Cell Factory'. Organic and Biomolecular Chemistry, 10 (10):1949-1957. [DOI] Link to full text [Details]
Lestini, E; Robertson, K; Murphy, CD; Paradisi, F (2012) 'An alternative mild route to the synthesis of 4-methylenecyclohex-2-enone, a key moiety of the anticancer compounds ottelione A and B'. Synthetic Communications, 42 :1864-1876. [DOI] [Details]
T. Fukuda, E.D. Miller, B.R. Clark, A. Alnauman, C.D. Murphy, P.R. Jensen and W. Fenical ; (2011) 'Structures and Biosynthesis of the Pyridinopyrones, Polyenepyrones from a Marine-Derived Streptomyces Species'. Journal of Natural Products, 74 :1773-1778. [DOI] [Details]
Clark, B.R., O'Connor, S., Fox, D., Leroy, J and Murphy, C.D.; (2011) 'Production of anticancer polyenes through precursor-directed biosynthesis'. Organic and Biomolecular Chemistry, 9 (18):6306-6311. [DOI] Link to full text [Details]
Bright T, Clark B, O'Brien E, and Murphy CD (2011) 'Bacterial production of hydroxylated and amidated metabolites of flurbiprofen'. Journal of Molecular Catalysis B-Enzymatic, 72 :116-121. [DOI] Link to full text [Details]
Misiak, K., Casey, E. and Murphy, CD; (2011) 'Factors influencing 4-fluorobenzoate degradation in biofilm cultures of Pseudomonas knackmussii B-13'. Water Research, 45 (11):3512-3520. Available Online [Details]
Hughes D, Clark BR, Murphy CD; (2011) 'Biodegradation of polyfluorinated biphenyl in bacteria'. Biodegradation, 22 (4):741-749. [DOI] Link to full text [Details]
Amadio, J., Gordon, K. and Murphy, C.D. ; (2010) 'Biotransformation of flurbiprofen by Cunninghamella species'. Applied and Environmental Microbiology, 76 :6299-6303. [DOI] [Details]
Amadio, J. and Murphy, C.D.; (2011) 'Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species'. Biotechnology Letters, 33 :321-326. [DOI] Link to full text [Details]
S. Moran, K. Robertson, F. Paradisi, D. Rai and C.D. Murphy ; (2010) 'Production of lipopeptides in Bacillus sp. CS93 isolated from Pozol'. Fems Microbiology Letters, 304 (1):69-73. [DOI] Link to full text [Details]
Higginbotham S and Murphy CD; (2010) 'Isolation and characterisation of a Streptomyces sp. isolate exhibiting activity against methicillin-resistant Staphylococcus aureus'. Microbiological Research, 165 (1):82-86. [DOI] [Details]
Amadio J and Murphy CD; (2010) 'Biotransformation of fluorobiphenyl in Cunninghamella elegans'. Applied Microbiology and Biotechnology, 86 :345-351. [DOI] Link to full text [Details]
Murphy CD; (2010) 'Biodegradation and biotransformation of organofluorine compounds'. Biotechnology Letters, 32 :351-359. [DOI] [Details]
Murphy, C., Clark, B and Amadio, J.; (2009) 'Metabolism of fluoroorganic compounds in microorganisms: Impacts for the environment and the production of fine chemicals'. Applied Microbiology and Biotechnology, 84 (4):617-629. [DOI] Link to full text [Details]
Heffernan, B,Murphy, CD,Syron, E,Casey, E; (2009) 'Treatment of Fluoroacetate by a Pseudomonas fluorescens Biofilm Grown in Membrane Aerated Biofilm Reactor'. Environmental Science and Technology, 43 :6776-6785. [DOI] [Details]
Moran, S., Rai, D. Clark, B. and Murphy, C.; (2009) 'Precursor-directed biosynthesis of fluorinated iturin A in Bacillus subtilis'. Organic and Biomolecular Chemistry, 7 :644-646. Available Online [DOI] [Details]
Cobb, S.L. and Murphy, C.D.; (2009) 'F-19 Applications in Chemical Biology'. Journal of Fluorine Chemistry, 130 :132-143. [DOI] [Details]
Clark BR and Murphy CD; (2009) 'Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum'. Organic and Biomolecular Chemistry, 7 :111-116. Available Online [DOI] Link to full text [Details]
Heffernan,B ., Murphy, C. and Casey, E.; (2009) 'Comparative performance of planktonic and biofilm cultures of Pseudomonas fluorescens DSM 8341 grown on fluoroacetate'. Applied and Environmental Microbiology, 75 (9):2899-2907. Available Online [DOI] [Details]
Donnelly, C. and Murphy C.; (2009) 'Purification and properties of fluoroacetate dehalogenase from Pseudomonas fluorescens DSM8341'. Biotechnology Letters, 31 :245-250. Available Online [DOI] [Details]
Murphy, C.D., Quirke, S. and Balogun, O; (2008) 'Degradation of fluorobiphenyl by Pseudomonas pseudoalcaligenes KF707'. Fems Microbiology Letters, 286 :45-49. [Details]
Donnelly C and Murphy C; (2007) 'Bacterial defluorination of 4-fluoroglutamic acid'. Applied Microbiology and Biotechnology, 77 :699-703. [Details]
C.D. Murphy; (2007) 'The Application of 19F NMR to Investigate Microbial Biotransformations of Organofluorine Compounds'. Omics: A Journal of Integrated Biology, 11 (3):314-324. [Details]
C.D. Murphy; (2007) 'Fluorophenol oxidation by fungal chloroperoxidase'. Biotechnology Letters, 29 :45-49. [Details]
Murphy, C.D.; (2006) 'Recent developments in enzymatic chlorination'. Natural Product Reports, 23 (2):147-152. [Details]
Hutchinson, RI; Grant, RJ; Murphy, CD; ; (2006) 'Biosynthetic origin of [R-(Z)]-4-amino-3-chloro-2-pentenedioic acid in Streptomyces viridogenes'. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 70 (12):3046-3049. [Details]
Boersma, F.H. McRoberts, W.C., Cobb, S.L. and Murphy, C.D.; (2004) 'A 19F NMR study of fluorobenzoate biodegradation by Sphingomonas sp. HB-1'. Fems Microbiology Letters, 237 :355-361. [Details]
C.D. Murphy, C. Schaffrath and D. OHagan; (2003) 'Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in S. cattleya'. Chemosphere, 52 :455-461. [Details]
C.D. Murphy; (2003) 'New frontiers in biological halogenation'. Journal of Applied Microbiology, 94 :539-548. [Details]
D. O'Hagan, C. Schaffrath, S.L. Cobb, J.T.G. Hamilton and C.D. Murphy; (2002) 'Biosynthesis of an organofluorine molecule'. Nature, 416 :279-279. [Details]
C.D. Murphy, S.J. Moss and D. OHagan; (2001) 'Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya'. Applied Environmental Microbiology, 67 :4919-4921. [Details]
C. Schaffrath, C.D. Murphy, J.T.G. Hamilton and D. OHagan; (2001) 'Biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Incorporation of oxygen-18 from [2-2H, 2-18O]-glycerol and the role of serine metabolites in fluoroacetaldehyde biosynthesis'. Journal of The Chemical Society-Perkin Transactions 1, :3100-3105. [DOI] [Details]
C.D. Murphy, D. OHagan and C. Schaffrath; (2001) 'Identification of a PLP-dependent threonine transaldolase: A novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya'. Angewandte Chemie-International Edition in English, 40 :4479-4481. [Details]
C.D. Murphy, R. M. Moore and R.L. White; (2000) 'Peroxidases from marine microalgae'. Journal of Applied Phycology, 12 :507-513. [Details]
S.J. Moss, C.D. Murphy, J.T.G. Hamilton, W.C. McRoberts, D.OHagan, C. Schaffrath and D.B. Harper; (2000) 'Fluoroacetaldehyde: a precursor of both fluoroacetate and 4-fluorothreonine in Streptomyces cattleya'. Chemical Communications, :2281-2282. [Details]
C.D. Murphy, R. M. Moore and R.L. White; (2000) 'An isotopic labelling method for determining production of volatile organohalogens by marine microalgae'. Limnology and Oceanography, 45 :1868-1871. [Details]
J.T.G. Hamilton, C.D. Murphy, M.R. Amin, D. OHagan and D.B. Harper; (1998) 'Exploring the biosynthetic origin of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya'. Journal of The Chemical Society-Perkin Transactions 1, :759-767. [DOI] [Details]
J. Nieschalk, J.T.G. Hamilton, C.D. Murphy, D.B. Harper and D. OHagan; (1997) 'Biosynthesis of fluoroacetate and 4-fluorothreonine by Streptomyces cattleya. The stereochemical processing of glycerol'. Chemical Communications, :799-800. [Details]
M.R. Amin, D.B. Harper, J.M. Moloney, C.D. Murphy, J.A.K. Howard and D. OHagan; (1997) 'A short, highly stereoselective synthesis of the fluorinated natural product (2S, 3S)-4-Fluorothreonine'. Chemical Communications, :1471-1472. [Details]

Other Journals

Murphy, C; Sandford, G (2015) 'Fluorinated pharmaceuticals: synthesis and opportunities' European Biopharmaceutical Review :72-74. [Details]

Conference Publications

Semiao, A; Gazzola, G; Habimana, O; Heffernan, R; Murphy, C; Casey, E (2012) Understanding the mechanism of biofouling on nanomembranes: Effect of the biofilm structure on solute removal Euromembrane Conference 2012 , pp.1557-1560 [Details]
Clark, B.R. and Murphy, C.D.; (2010) Biosynthesis of polyenes from Auxarthron umbrinum . In: S.K. Wrigley, R. Thomas, N. Nicholson and C. Bedford eds. Functional Molecules from Natural Sources Oxford, UK, , 06-JUL-09 - 08-JUL-09 , pp.209-216 [DOI] [Details]
                                                                                                                                       

Research

Research Interests

Research conducted in my laboratory is concerned with the microbial biosynthesis and biotransformation of halogenated compounds, mainly focused on those that contain fluorine.  Approximately 25 % of drugs are fluorinated, and there are an ever-growing number of organofluorine compounds that are released into the environment, where they come into contact with microorganisms and are transformed, possibly to more reactive/toxic metabolites.  Examples of projects that are currently on-going in my research group are:

  • Production of drug metabolites using fungal biofilms.  Environmental Protection Agency Doctoral Scholarship.
  • Fluorinated drug development using a microbial-chemical approach.  In collaboration with Prof Graham Sandford, Durham University and supported by the Royal Society.
  • Development of 19F NMR as a tool for analysing steroid degradation in anti-doping samples. In collaboration with Dr Steven Cobb, Durham University, funded by Leverhulme trust.
  • Bacterial biotransformation of ayrl-SF5 compounds.  Supported by Marie Curie ITN FLUOR21.
  • Cytochromes P450 of Cunninghamella elegans as biocatalysts for organofluorine biotransformations.  Supported by Marie Curie ITN FLUOR21.


Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Investigation of Fengycin Mechanism Using Biological, Chemical and Biophysical Tools
Start Date / End Date : 01-SEP-17 / 01-SEP-21
Sponsor : Irish Research Council (IRC)
Title : Emerging fluorinated pollutants: Biodegradation of aryl sulfanyl pentafluorides
Start Date / End Date : 01-OCT-15 / 30-NOV-16
Sponsor : Royal Embassy of Saudi Arabia
Title : Application of Fluorine-19 Nuclear Magnetic Resonance in Monitoring Microbial Contamination in Active Urine Samples.
Start Date / End Date : 02-SEP-13 / 31-AUG-17
Sponsor : EC Framework (FP7)
Title : FLUOR21: Synthesis, structure and function of fluorinated systems
Start Date / End Date : 01-MAR-14 / 28-FEB-18
Sponsor : University College Dublin (UCD)
Title : Workshop on catalytic biofilms for fine chemical production
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : Environmental Protection Agency (EPA)
Title : Fungal biofilm as a novel biocatalyst for production of important pharmaceutical compounds
Start Date / End Date : 20-MAY-13 / 20-OCT-16
Sponsor : University College Dublin (UCD)
Title : Fluorinated Drug Metabolism in Microorganisms - Oral presentation at the 243rd ACS National Conference
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Science Foundation Ireland (SFI)
Title : A biofilm catalyst for the production of drug metabolites
Start Date / End Date : 01-JAN-12 / 10-JUN-13
Sponsor : Enterprise Ireland (EI)
Title : Development of a bioreactor for production of drug metabolites for safety testing
Start Date / End Date : 01-FEB-12 / 01-APR-13
Sponsor : University College Dublin (UCD)
Title : M.Sc. Biotechnology research supervision
Start Date / End Date : 06-MAY-11 / 07-MAY-12
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Preparation and application of novel fluorinated iturin A analogs
Start Date / End Date : 04-OCT-10 / 03-OCT-13
Sponsor : Enterprise Ireland (EI)
Title : Structure and evaluation of the anti-MRSA antibiotic from a novel streptomycete
Start Date / End Date : 23-NOV-09 / 22-NOV-10
Sponsor : Environmental Protection Agency (EPA)
Title : Fungi and flourinated drugs: the development of microbial models of mammalian metabolism
Start Date / End Date : 01-OCT-08 / 30-SEP-11
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Biological Halogenationin th eFungus Gymnoascus Reesii
Start Date / End Date : 01-NOV-07 / 31-OCT-09
Sponsor : University College Dublin (UCD)
Title : Investigation of the fluorinase from streptomyces calvus
Start Date / End Date : 01-JUN-07 / 01-DEC-08
Sponsor : University College Dublin (UCD)
Title : Biosynthesis of fluorinated natural products in bacteria
Start Date / End Date : 01-JUN-02 / 31-DEC-03
Sponsor : Science Foundation Ireland (SFI)
Title : Cloning the biosynthetic genes for ACPA production
Start Date / End Date : 07-JUN-05 / 30-AUG-05
Sponsor : Health Research Board (HRB)
Title : The Biosynthesis of the Chlorinated Antibiotic ACPA
Start Date / End Date : 01-JAN-05 / 30-JUN-05
Sponsor : Science Foundation Ireland (SFI)
Title : Biosynthesis of the Chlorinated Antibiotic ACPA in Streptomyces viridogenes
Start Date / End Date : 01-OCT-04 / 31-OCT-07
Sponsor : Enterprise Ireland (EI)
Title : Investigation of the novel 4-Fluroglutamate Dehalogenase from Streptomyces Cattleya
Start Date / End Date : 01-OCT-03 / 30-APR-07
Sponsor : Enterprise Ireland (EI)
Title : Characterisation of the unusual thredonine transaldolase from streptomyles cattleya
Start Date / End Date : 01-JUN-02 / 30-JUN-02
Sponsor : Higher Education Authority (HEA)
Title : Removal of toxic compounds from waste streams using a pseudomonas biofilm
Start Date / End Date : 01-SEP-06 / 31-AUG-09
Sponsor : British Society for Antimicrobial Chemotherapy, UK
Title : Isolation of the anti-MRSA antibiotic from a new Streptomyces sp
Start Date / End Date : 01-MAY-06 / 31-DEC-06
Sponsor : Enterprise Ireland (EI)
Title : Efficacy of Panfan Device at Trapping Airborne Microorganisms
Start Date / End Date : 01-SEP-07 / 28-FEB-08

Recent Postgraduates

PhDs supervised:
 
2008: Clar Donnelly, Barry Heffernan

2009:  Robin Hutchinson, Sarah Higginbotham, Stephen Moran

2010: Katarzyna Misiak

2013: Jessica Amadio, Keith Robertson

2014: Tara Bright 

2015: Neil O'Connor, Paul Sweeney

2016: Laura Quinn, Fahimeh Khorsand, Giulio Gazzola 


Current Postgraduate Students

Aoife Phelan, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Radwan BaAbbad, Doctor of Philosophy (PhD)   -   Thesis Supervisor
William Palmer-Brown, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Marta Saccomanno, Doctor of Philosophy (PhD)   -   Thesis Supervisor
James Sheehan, Doctor of Philosophy (PhD)   -   Thesis Co-Supervisor

Teaching

Teaching Philosophy

I aim to create a positive learning environment, using a variety of teaching tools, to enable students to develop their own interest in the subject matter that extends beyond the end of the module.
         

Collaborators

Internal Collaborators

Prof Eoin Casey, School of Chemical and Bioprocess Engineering
Dr Francesca Paradisi, School of Chemistry/CSCB
Dr Andrew Phillips, School of Chemistry 
Dr Patrick Caffrey, SBBS
Dr Dr Kevin McDonnell, Crop Science & Biosystems Engineering  

External Collaborators

Professor Graham Sandford, Dept of Chemistry, University of Durham, UK (Funded by the Royal Society)

Dr Steven Cobb, University of Durham, UK (Leverhulme Trust grant)

Dr Petr Bier, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic