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John O'Connor

Associate Professor

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: 7166765
Email: john.oconnor@ucd.ie

Biography

2017 - Teaching Excellence Award from the College of Science

2016 - Chair UCD Widening Participation Sub Group Student Supports & Campus Facilities


2015 - Associate Dean Widening Participation, Science

2012 - Awarded the Conway Silver Medal from the Royal Academy of Medicine in Ireland

2010 - Conway Fellow

2009-2012: Head of Neuroscience

2009-2012: Adjunct Senior Lecturer,  Department of Chemistry, NUIM, Maynooth

2004 to 2011: Chief Executive Officer (General Secretary), Royal Academy of Medicine in Ireland.

2003-2004: President, Royal Academy of Medicine in Ireland, Biomedical Sciences Section.

2000 to 2006: Coordinator of Conway PRTLI Neuroscience

1998 -  Senior Lecturer in Physiology, Department of Human Anatomy & Physiology (now School of Medicine), University College Dublin.

1994 to 1998: College Lecturer, Department of Human Anatomy & Physiology, UCD

1991 to 1993: HRB Post Doctoral Fellow, Department of Pharmacology & Therapeutics, Trinity College

1989 to 1991: Glaxo Post Doctoral Fellowship, The London Hospital and Queen Mary & Westfield College, London.

1986 to 1989: PhD in Pharmacology, Department of Pharmacology & Therapeutics, Trinity College Dublin.

1981 to 1985: BA (Mod) in Physiology, Trinity College Dublin

Research Links: SBBS Research  |  Mechanisms of Disease Research in SBBS  |  Model Organisms Research in SBBS
 
Conway, B.Sc. Neuroscience, long-term potentiation, hippocampus, tumor necrosis factor alpha, glutamate, fast cyclic voltammetry, dopamine release, Royal academy of medicine in Ireland

Professional

Honours and Awards

Year: 2012.
Title: Conway Silver Medal
Year: 2017.
Title: Teaching Excellence Award
Year: 2012.
Title: UCD Seed Funding 2012
Year: 2016.
Title: UCD Seed Funding
Year: 2009.
Title: Adjunct Senior Lecturer, NUIM
Year: 2010.
Title: Conway Fellow, UCD
Year: 2008.
Title: UCD Seed Funding
Year: 1997.
Title: President's Prize UCD
Year: 1999.
Title: President's Prize UCD
Year: 1991.
Title: Health Research Board Post-doctoral fellowship
Year: 1997.
Title: Delaney Medal Competition winner with Dr Michael Griffin
Year: 1994.
Title: Travel grant awarded by the Physiological Society to attend the Society for Neuroscience meeting, Miami,
Year: 1989.
Title: Glaxo Post-Doctoral Fellowship
Year: 1987.
Title: Travel grant awarded by The Pharmacology Society to attend Society Meeting
Year: 1985.
Title: Health Research Board Summer Vacation Award

Associations

Association: The Physiological Society, Function/Role: Ordinary Member
Association: British Pharmacological Society, Function/Role: Member
Association: Society for Neuroscience, Function/Role: Member
Association: Royal Academy of Medicine in Ireland, Function/Role: Fellow
Association: Irish Neuroscience Discussion group, Function/Role: Executive Member
Association: Neuroscience Ireland, Function/Role: Member
     

Conference Contributions

Corcoran, A.E., O¿Connor, J.J. (2011) The effects of hypoxia and PHD inhibition on synaptic transmission in the rat hippocampus. [Poster Presentation], Hypoxianet, Davos, Switzerland , 12-JAN-11 - 15-JAN-11.
Murphy, K. J.; Pickering, M.; Watters, O.; Halley, P. G.; O'Sullivan, N. C.; Mooney, C.; O'Connor, J. J.; Sheridan, G. K. (2012) CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity. [Poster Presentation], Annual Meeting of the Society-for-Neuroscience, New Orleans , 13-OCT-12 - 17-OCT-12.
Corcoran, A.E., Harney, S.C., O¿Connor, J.J. (2012) Prolyl hydroxylase inhibition impairs long-term potentiation in the rat hippocampus. [Poster Presentation], FENS, Barcelona , 08-JUL-12 - 12-JUL-12.
O'Connor J.J. (2012) Targeting TNF-α in hypoxia and synaptic signalling. [Invited Lecture], CLASS lecture Conway Institute UCD, UCD , 04-DEC-12 - 04-DEC-12.
O'Connor J.J. (2012) Targeting TNF-α in hypoxia and synaptic signalling. [Keynote Address], Royal Academy of Medicine in Ireland, Section of Biomedical Sciences, NUIG , 14-JUN-12 - 15-JUN-12.
Wall, A.M., O¿Connor, J.J. (2012) Tumour necrosis factor alpha does not impair long term potentiation following an acute hypoxic insult. [Poster Presentation], FENS, Barcelona , 08-JUL-12 - 12-JUL-12.
Mukandala, G.D., O¿Connor, J.J. (2012) TNF-α synthesis inhibition post hypoxia impairs long-term potentiation in the dentate gyrus in vitro. [Poster Presentation], FENS, Barcelona , 08-JUL-12 - 12-JUL-12.
Corcoran, A.E., Kunze, R., Harney, S.C., Breier, G., Marti, H.H., and O¿Connor, J.J. (2013) A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity. [Poster Presentation], Hypoxianet, Oulu, Finland , 05-JUN-13 - 10-MAY-13.
O'Connor J.J. (2016) Understanding Parkinson's Disease. [Invited Lecture], Parkinsons Society of Ireland, Navan road Dublin , 08-DEC-16 - 08-DEC-16.
O'Connor J.J. (2016) Risk Taking and Addiction in Teenagers: What is going on in their heads?. [Invited Lecture], Biological Society UCD, UCD , 08-NOV-16 - 08-NOV-16.
O'Connor J.J. (2017) Current research in Parkinson's Disease. [Invited Lecture], Parkinsons Society of Ireland, Dublin Branch, Sutton, Dublin , 20-JUN-17 - 20-JUN-17.
Lanigan S., OConnor J.J. (2016) The acute effects of the hypoxia mimetic protocatechuic acid ethyl ester on synaptic transmission and plasticity in the rat hippocampus. [Poster Presentation], Young Scientist Symposium, Physiological Society, Trinity College Dublin , 29-JUL-16 - 31-JUL-16.
Lanigan S & O¿Connor JJ. (2015) The effect of hypoxia and the hypoxia mimetic protocatechuic acid ethyl ester (EDHB) on synaptic transmission and plasticity in the rat dentate gyrus. [Poster Presentation], Conway Festival of Research 2015, UCD , 14-SEP-16 - 15-SEP-16.
Audrey Wall, Gatambwa Mukandala, John J. O' Connor (2014) Hypoxic pre-conditioning improves the recovery of synaptic transmission in the hippocampus. [Poster Presentation], Conway Festival of Research 2014, Conway Institute, UCD , 10-SEP-14 - 10-SEP-14.
Pickering M & O¿Connor J.J. (2005) Conway Institute. [Oral Presentation], Conway Festival of Research, UCD , 21-SEP-05 - 21-SEP-05.
Audrey M. Wall, Gatambwa Mukandala, John J. O¿Connor (2013) A novel role for tumor necrosis factor-αin synaptic plasticity after acute hypoxia in the rat dentate gyrus. [Poster Presentation], Frontiers in Neurology, University of Dublin, Trinity College , 15-NOV-13 - 15-NOV-13.
O'Connor JJ (2013) A new role for prolyl hydroxylase in synaptic signalling. [Plenary Lecture], British Neuroscience Association, The Barbican London , 07-APR-13 - 10-APR-13.
Corcoran A.E., O'Connor JJ. (2011) Dimethyloxalyl Glycine Decreases Synaptic Signalling and Impairs Long Term Potentiation in the Rat Hippocampus. [Poster Presentation (Refereed)], Neuroscience Ireland, NUI Maynooth , 16-JUN-11 - 16-JUN-11.
Wall, A.M., O'Connor JJ. (2011) Acute hypoxia impairs the recovery of synaptic transmission in the rat dentate gyrus and potentiates long-term potentiation in the presence of tumour necrosis factor- and picrotoxin. [Poster Presentation (Refereed)], Neuroscience Ireland, NUI Maynooth , 16-JUN-11 - 16-JUN-11.
O¿Connor, J.J., Dalton, M., Cavanni, P., Large, C.H. Lowry, J.P. (2011) A comparison of the effects of the dopamine partial agonists aripiprazole and (-)- 3-PPP with quinpirole on stimulated dopamine release in the rat striatum: studies using fast cyclic voltammetry in vitro. [Poster Presentation (Refereed)], Neuroscience Ireland, NUI Maynooth , 16-JUN-11 - 16-JUN-11.
Fanning,, R.A., Duffy N., McMorrow, J.P., Campion, D.P., Carey M.F., O¿Connor J.J. (2012) Opioid mediated activity in human term non-laboring myometrium. [Poster Presentation (Refereed)], RAMI Section of Biomedical Sciences, Galway , 14-JUN-12 - 14-JUN-12.
Fanning, RA, Duffy N., Leonard M., Ahmed J.J., O¿Connor J.J. (2012) The oxytocic effect of ergometrine on human myomterium in vitro does not involve 5-HT2 receptor activation. [Poster Presentation (Refereed)], RAMI Section of Biomedical Sciences, Galway , 14-JUN-12 - 14-JUN-12.
Mukandala, G., O¿Connor, J.J. (2012) 3,6¿-Dithiothalidomide, the TNF-α synthesis inhibitor applied pre-hypoxia, impairs long-term potentiation in the rat dentate gyrus in vitro. [Poster Presentation (Refereed)], RAMI Section of Biomedical Sciences, Galway , 14-JUN-12 - 14-JUN-12.
Wall, A.M., O¿Connor, J.J. (2012) Acute hypoxia impairs the recovery of synaptic transmission in the rat dentate gyrus but does not impair induction of long term potentiation in the presence of picrotoxin and tumour necrosis factor-α or interleukin-1β. [Poster Presentation (Refereed)], RAMI Section of Biomedical Sciences, Galway , 14-JUN-12 - 14-JUN-12.
Fanning, RA, Duffy N., Leonard M., Ahmed J.J., O'Connor J.J. (2012) Published in International journal of Obstetric Anaesthesia. [Poster Presentation], Obstetric Anaesthetists' Association, Liverpool , 24-MAY-12 - 24-MAY-12.
A.E. Corcoran, J.J. O¿Connor; (2011) Annual Conway institue festival of research. [Poster Presentation], Conway Festival of Research, Conway Institute , 09-SEP-11 - 09-SEP-11.
A.M.Wall, J.J. O'Connor. ; (2011) Annual Conway institute festival of research. [Poster Presentation], Conway Festival of Research, Conway Institute UCD , 09-SEP-11 - 09-SEP-11.
Batti, L., Taylor C. & O¿Connor J.J. ; (2007) A role for adenosine receptors in hypoxia in rat hippocampal slices. [Poster Presentation], IAS Biochemical Society Annual Symposium 23rd November, RCSI , 23-NOV-07 - 23-NOV-07.
O¿Neill C & O¿Connor JJ. ; (2007) Adenosine A1 receptor-mediated inhibition of dopamine release from rat striatal slices is modulated by GABAa receptor activation. [Poster Presentation], Irish Neurosciences Discussion Group, Tullamore , 23-NOV-07 - 24-NOV-07.
Watters O, Sheridan GK, Murphy KJ, O¿Connor JJ, & Pickering M. ; (2007) TNFα modulates glutamate excitotoxicity and ischemic pre-conditioning depending on the time and order of TNFα and glutamate exposure. [Poster Presentation], Irish Neurosciences Discussion Group, Tullamore , 23-NOV-07 - 24-NOV-07.
Batti, L., Taylor C. & O¿Connor J.J. ; (2007) Characterization of neuronal responses to hypoxia in rat hippocampal slices. [Poster Presentation], Irish Neurosciences Discussion Group, Tullamore , 23-NOV-07 - 24-NOV-07.
Sheridan G., Pickering M., Moynagh P.N., O¿Connor J.J. and Murphy K.J. ; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations. [Oral Presentation], Royal Academy of Medicine in Ireland, Biomedical Sciences Section, UCD , 12-JAN-06 - 12-JAN-06.
O¿Neill C., O¿Connor, J.J. ; (2006) The role of D1-like receptors in the A1 receptor-mediated inhibition of electrically evoked dopamine release from rat striatal slices. [Oral Presentation], Irish Neurosciences Discussion Group, Tullamore , 24-NOV-06 - 25-NOV-06.
Sheridan, G., O¿Connor, J.J. ; (2006) The role of NFκB in memory-associated synaptic plasticity. [Poster Presentation], Irish Neurosciences Discussion Group, Tullamore , 24-NOV-06 - 25-NOV-06.
Pickering M., O¿Connor, J.J. ; (2006) Discrimination of neuronal and non-neuronal cells in mixed primary cortical culture using calcium imaging. [Oral Presentation], Irish Neurosciences Discussion Group, Tullamore , 24-NOV-06 - 25-NOV-06.
O¿Neill C, B. Nolan, K. O¿Boyle, J. J. O¿Connor ; (2005) Modulation of dopamine release by adenosine in the rat striatum in vitro: studies using fast cyclic voltammetry. [Oral Presentation], Royal Academy of Medicine in Ireland, Biomedical Sciences Section, Galway Univ , 16-JUN-05 - 17-JUN-05.
O¿Neill, C & O¿Connor J.J. ; (2004) Sinapsa neuroscience conference Workshop. [Poster Presentation], Cognitive Neuroscience Summer School on Working Memory, 12th July, Bled, Slovenia , 10-JUL-04 - 17-JUL-04.
O' Connor, J.J.; (2002) Neuroimmune modulation of synaptic plasticity. [Invited Oral Presentation], Euroconference on molecular mechanisms and clinical relevance of brain-immune communication, San Feliu de Guixols, Spain , 05-OCT-02 - 10-OCT-02.
O' Connor, J.J.; (2001) (2001, June). A role for cytokines in synaptic plasticity. [Invited Oral Presentation], Symposium on 9th International Conference on in Vivo Methods: Monitoring Molecules in Neuroscience, UCD , 15-JUN-01 - 17-JUN-01.
O' Connor, J.J.; (1998) (1998, Jan). IL-1b, memory and Alzheimer's disease; a connection. [Invited Lecture], Royal Academy of Medicine in Ireland, Biomedical Sciences Section, RCSI , 04-JAN-98 - 04-JAN-98.
O' Connor, J.J.; (1997) (1997, April, 25). NMDA receptors versus mGluRs in long-term potentiation; is there a result?. [Invited Oral Presentation], Istituto di Fisiologia Generale, Universita' di Pavia, Via Forlanini 6, I- 27100 Pavia, Italy , 25-APR-97 - 27-APR-97.
O'Connor, J.J. & Curran, B.P; (2003) The inhibitory effects of pro-inflammatory cytokines on LTP are attenuated by nicotine. [Poster Presentation], Physiological Society, Tenerife , 13-FEB-03 - 17-FEB-03.
Cumiskey, D. & OConnor, J.J; (2003) Role for NFkB in LTP and LTD?. [Poster Presentation], American Neuroscience Meeting, New Orleans , 07-NOV-03 - 11-NOV-03.
Cumiskey, D. & OConnor, J.J.; (2003) An investigation into the effect of putative nfkb inhibitors on ltp and ltd. IL-1 in the CNS. [Invited Oral Presentation], IL-1 in the CNS, Manchester , 20-JUL-03 - 23-JUL-03.

Committees

Committee : Assessment Appeals Committee (AAC)
Committee : Board of Studies Access
Committee : Widening Participation Student Support Committee
Committee : Neuroscience Teaching Committe
Committee : Animal Wefare Board Sub Committee
Committee : Animal Research Ethics Committee
Committee : UCD Widening Participation Committee
Committee : College Science Executive Committee
Committee : Science Program Board, UCD

Employment

Employer: NUIM
Position: Adjunct Senior Lecturer
Employer: University College Dublin
Position: College Lecturer
Employer: University College Dublin
Position: Senior Lecturer
Employer: QMW College, London
Position: Postdoctoral Fellow
Employer: TCD
Position: Postdoctoral Fellow, Pharmacology

Education

Year 2016 Institution: University College Dublin
Qualification: Prof Cert in Teaching and Learning Subject: Professional Certificate in Teaching and Learning
Year 2016 Institution: University College Dublin
Qualification: Certificate Subject: Professional Certificate in Teaching and Learning
Year 2016 Institution: University College Dublin
Qualification: Professional Certificate in University Teaching & Learning Subject: Teaching and Learning
Year 1985 Institution: Trinity College Dublin
Qualification: BA Subject:
Year 1989 Institution: Trinity College Dublin
Qualification: PhD Subject:
Year 1998 Institution: University College Dublin
Qualification: Cert Safety & Health at Work Subject:
   

Outreach Activities

Irish Parkinson's Disease Association, Dublin Branch, Guest Speaker June 2017
Irish Parkinson's Disease Association, Dublin Branch, Guest Speaker June 2016

Chair Medical Faculty Open Day committee 1998 to 2003

Director Medical Students Overseas Relief, 1997 to 1999
St Louis SPS outreach talk 10 June 2016
St. Killian's German School Outreach talk 17 October 2016
Associate Dean for Widening Participation Science UCD  2015-2018

Chair Medical Faculty School liaison committee 1997 to 2004

Journals Edited

American Journal Of Physiology: Reviewer.
Brain, Behavior, And Immunity: Reviewer.
Journal Of Neuroscience: Reviewer.
Neurobiology Of Disease: Reviewer.
Journal Of Psychopharmacology (Oxford, England): Reviewer.
Journal Of Visualized Experiments : Jove: Reviewer.
International Journal Of Developmental Neuroscience: Reviewer.
Neuropharmacology: Reviewer.
Neuroscience Letters: Reviewer.
Cytokine: Reviewer.
Pharmacology, Biochemistry And Behaviour: Reviewer.
Journal Of Psychopharmacology (Oxford, England): Reviewer.
Journal Of Neuroinflammation: Reviewer.
Brain Research: Reviewer.
Journal Of Neuroscience: Reviewer.
Experimental Brain Research: Reviewer.
American Journal Of Physiology: Reviewer.
British Journal Of Pharmacology: Reviewer.
European Journal Of Neuroscience: Reviewer.
Experimental Neurology: Reviewer.
Journal Of Neuroimmunology: Reviewer.
Journal Of Neuroscience Methods: Reviewer.
Neuroreport: Reviewer.
Neuroscience: Reviewer.
Irish Journal Of Medical Science: Editorial Board member.
Trends In Neurosciences: Reviewer.
Journal Of Neurochemistry: Reviewer.
Neuropharmacology: Reviewer.
Journal Of Neurophysiology: Reviewer.
 

Publications

 

Book Chapters

O'Connor J.J. (2017) 'It is really difficult to read scientific papers: teach me how' In: Bennet, L., Barry, T., O'Connor, J.J (eds). Universal Design for Curriculum Design: Case studies from UCD. UCD: UCD Access & Lifelong Learning. [Details]
Pickering, M. & O'Connor J.J; (2007) 'Pro-inflammatory cytokines and their effects in the dentate gyrus' In: Scharfman, H (eds). Progress in Brain Research Volume 163 The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications. USA: Elsevier. , pp.339-354 Available Online [Details]
Butler M.P., Moynagh P.N. & O'Connor J.J.; (2001) 'Methods of detection of the transcription factor NFkB in rat hippocampal slices' In: O'Connor W.T., Lowry J.P. O'Connor J.J. & O'Neill R.D (eds). Monitoring molecules in neuroscience. Dublin: UCD Press. , pp.204-206 [Details]
Curran B. & OConnor J.J.; (2001) 'Interleukin-1 receptor antagonist reverses the impairment of long-term potentiation by the pro-inflammatory cytokine interleukin-18 in the rat dentate gyrus in vitro' In: O'Connor, W.T., Lowry, J.P., O'Connor, J.J. & O'Neill, R.D (eds). Monitoring molecules in Neuroscience. Dublin: UCD Press. , pp.202-203 [Details]
Murray H.J. & O'Connor J.J.; (2001) 'A new role for the p38 mitogen activated protein kinase cascade in synaptic plasticity' In: O'Connor, W.T., Lowry, J.P., O'Connor, J.J. & O'Neill, R.D (eds). Monitoring molecules in Neuroscience. Dublin: UCD Press. , pp.198-199 [Details]
Kruk ZL, OConnor JJ, Patel J, Trout SJ (1993) 'Recent developments in fast cyclic voltammetry in-vivo and in-vitro' In: Kruk ZL, OConnor JJ, Patel J, Trout SJ (eds). BIOELECTROANALYSIS, 2. BUDAPEST: AKADEMIAI KIADO. [Details]
O'Connor J.J. & Kruk Z.L.; (1991) 'Real time measurement of electrically stimulated endogenous 5-hydroxytryptamine overflow in the rat brain using fast cyclic voltammetry' In: Rollema, H., Westerink, B & Drijfhout, W.J (eds). Monitoring molecules in Neuroscience. , pp.265-267 [Details]
Rowan, M.J., Anwyl, R. & O'Connor, J.J.; (1990) 'Neurophysiological actions of ECT and antidepressants on serotonergic and excitatory synaptic transmission' In: Leonard, B. & Spencer, P (eds). Antidepressants: Thirty Years On. England: CNS Publications. , pp.231-244 [Details]
Rowan, M.J., O'Connor, J.J. & Anwyl, R.; (1989) 'Spiroxatrine antagonises the inhibitory effects of acute and chronic buspirone treatment in the rat hippocampus' In: Vanhoutte, P.M., Paoletti, R., Brunello, N., Maggi, F.M (eds). Serotonin from cell biology to pharmacology and therapeutics. Florence, Italy: Kluwer Academic Publishers. , pp.52-55 [Details]

Edited Books

Bennet, L., Barry, T., O'Connor, J.J (Ed.). (2017) Universal Design for Curriculum Design: case studies from University College Dublin. UCD: Access & Lifelong Learning. [Details]
O'Connor John J (Ed.). (2015) Neuroimmunology and Synaptic Function; Special Edition of Neuropharmacology. Amsterdam: Elsevier. [Details]
O'Connor W, O'Connor JJ, Lowry J & O'Neill R (Ed.). (2002) Monitoring Molecules in Neuroscience, Journal of Neuroscience Methods, Special Edition. Amsterdam: Elsevier. [Details]
O'Connor, W.T., Lowry, J.P., O'Connor, J.J. & O'Neill, R.D (Ed.). (2001) Monitoring Molecules in Neuroscience. UCD: UCD Publication. [Details]

Peer Reviewed Journals

Fanning, R.A., Sheehan, F., Leyden, C., Duffy, N., Carey, M.F., Campion D.P., O'Connor, J.J. (2017) 'A role for adrenergic receptors in the uterotonic effects of ergometrine in isolated human term non-laboring myometrium'. Anesthesia and Analgesia, 124 (5):1581-1588. [DOI] Link to full text [Details]
O'Connor, J.J., O'Boyle, K.M., Lowry, J.P (2017) 'Effects of caffeine and MDMA on real-time stimulated single pulse dopamine release in the rat striatum'. Journal of Neuroscience Methods, 291 (3):1-8. [DOI] [Details]
Fanning R.A., O¿Shea M., Carey M.F., Campion D.P., O¿Connor J.J. (2017) 'A comparison of the effects of lindane and FeCl3 on spontaneous contractions in isolated rat and human term myometrium'. Reproductive Toxicology, . [Details]
Lanigan, S.M., O¿Connor J.J. (2017) 'The hypoxia mimetic protocatechuic acid ethyl ester inhibits synaptic signaling and plasticity in the rat hippocampus'. Neuroscience, . [Details]
Daly C., Shine L., Heffernan T., Deeti S., Reynolds A., O¿Connor J.J., Dillon E., Duffy D., Kolch W., Cagney G., Kennedy B.N. (2017) 'A brain-derived neurotrophic factor mimetic is sufficient to restore cone photoreceptor visual function in an inherited blindness model'. Scientific Reports, 7 :11230. [DOI] [Details]
Goutier W, Lowry, JP, McCreary AC O¿Connor JJ, (2016) 'Frequency-dependent modulation of dopamine release by nicotine and dopamine D1 ligands: an in vitro fast cyclic voltammetry study in rat striatum'. Neurochemical Research, 41 (5):945-950. [DOI] Link to full text [Details]
Mukandala, G, Tynan R, Lanigan, S, O'Connor JJ. (2016) 'The effects of hypoxia and inflammation on synaptic function in the CNS'. Brain Sciences, 6 (6):1-14. [DOI] Link to full text [Details]
Goutier W, O'Connor JJ. Lowry, JP, McCreary AC (2015) 'The effect of nicotine induced behavioral sensitization on dopamine D1 receptor pharmacology: An in vivo and ex vivo study in the rat'. European Neuropsychopharmacology, 25 (6):933-943. [DOI] Link to full text [Details]
O'Connor JJ (2015) 'Neuroimmunology and synaptic function'. Neuropharmacology, 96 (1):1-3. [DOI] Link to full text [Details]
Audrey M. Wall, Gatambwa Mukandala, Nigel H. Greig, John J. O'Connor (2015) 'Tumor necrosis factor-alpha potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia'. Journal of Neuroscience Research, 93 (5):815-829. [DOI] Link to full text [Details]
Sheridan, G.K., Moeendarbary E., Pickering M., O'Connor J.J., Murphy K.J. (2014) 'Theta-burst stimulation of hippocampal slices induces network-level calcium oscillations and activates analogous gene transcription to spatial learning'. PLoS ONE, 9 (6):e100546-e100546. [DOI] Link to full text [Details]
Sheridan GK, Wdowicz A, Pickering M, Watters O, Halley P, O'Sullivan NC, Mooney C, O'Connell DJ, O'Connor JJ, Murphy KJ (2014) 'CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity'. Frontiers in Cellular Neuroscience, 8 :1-15. Available Online [DOI] Link to full text [Details]
Wall, A., Corocoran, A., O'Halloran, K., O' Connor, J.J. (2014) 'Effects of prolyl hydroxylase inhibition and chronic intermittent hypoxia on synaptic plasticity in the rat hippocampus'. Neurobiology of Disease, 62 :8-17. [DOI] Link to full text [Details]
Watters, O., Pickering, M., Murphy, R., Murphy, K., O'Connor J.J (2014) 'Automated analysis of intracellular calcium fluorescence in rat organotypic hippocampal cultures: comparison to a manual, observer based method'. Journal of Neuroscience Methods, 223 :20-29. [DOI] Link to full text [Details]
Corcoran, A., OConnor J.J. (2013) 'Hypoxia inducible factor signaling mechanisms in the central nervous system'. Acta Physiologica Scandinavica, 208 (4):298-310. [DOI] Link to full text [Details]
Corcoran, A., Kunze, R., Harney, S.C., Breier, G., Marti, H.H., O'Connor, J.J. (2013) 'A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity'. Hippocampus, 23 (10):861-872. [DOI] Link to full text [Details]
O'Connor JJ (2013) 'Targeting TNF-alpha in hypoxia and synaptic signaling'. Irish Journal of Medical Science, 182 (2):157-162. [DOI] Link to full text [Details]
Fanning RA, McMorrow JP, Campion DP, Carey MF, O'Connor JJ (2013) 'Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium'. European Journal of Pharmacology, 698 (1-3):170-177. [DOI] Link to full text [Details]
OConnor JJ, Lowry JP (2012) 'A comparison of the effects of the dopamine partial agonists aripiprazole and 3-PPP with quinpirole on stimulated dopamine release in the rat striatum: studies using fast cyclic voltammetry'. European Journal of Pharmacology, 686 :60-65. [DOI] Link to full text [Details]
Watters O., O'Connor J.J. (2011) 'A role for tumor necrosis factor-alpha in ischemia and ischemic preconditioning'. Journal of Neuroinflammation, 8 :87-98. [DOI] Link to full text [Details]
Watters O, Pickering M, O'Connor J.J.; (2011) 'Preconditioning effects of tumor necrosis factor-α and glutamate on calcium dynamics in rat organotypic hippocampal cultures'. Journal of Neuroimmunology, 234 (1-2):27-39. [DOI] Link to full text [Details]
McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ. (2010) 'AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity'. Journal of Neurochemistry, 112 (4):991-1004. Available Online [DOI] [Details]
Batti, L., O'Connor, J.J. (2010) 'Tumor necrosis factor-alpha impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices'. Journal of Neuroimmunology, 218 (1-2):21-27. [DOI] [Details]
Batti L, Taylor CT, O'Connor JJ; (2010) 'Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus'. Neuroscience, 167 (4):1014-1024. [DOI] Link to full text [Details]
Alvarez Y, Chen K, Reynolds AL, Waghorne N, O'Connor JJ, Kennedy BN, ; (2010) 'Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy'. Disease models & mechanisms, 3 (3-4):236-245. [DOI] [Details]
Alvarez, Y,Astudillo, O,Jensen, L,Reynolds, AL,Waghorne, N,Brazil, DP,Cao, YH,O'Connor, JJ,Kennedy, BN; (2009) 'Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase'. PLoS ONE, 4 (11):1-10. [Details]
O'Neill C., Evers Donnelly, A., O'Boyle K.M. and O'Connor J.J. (2009) 'D2 receptor mediated inhibition of dopamine release from rat striatum is modulated by CB1 receptors: studies using fast cyclic voltammetry'. Journal of Neurochemistry, 108 (3):545-551. [DOI] [Details]
Carey MF, Fanning RA, Campion DP, Collins CB, Keely S, Briggs LP, O'Connor JJ, ; (2008) 'A comparison of the inhibitory effects of bupivacaine and levobupivacaine on isolated human pregnant myometrium contractility'. Anesthesia and Analgesia, 107 (4):1303-1307. [Details]
O'Connor JJ & O'Neill C; (2008) 'A Role for Adenosine A1 Receptors in GABA and NMDAReceptor Mediated Modulation of Dopamine Release: Studies Using Fast Cyclic Voltammetry'. Sensors, 8 :5229-5237. Available Online [Details]
Pickering M, Pickering BW,Murphy KJ, O'Connor JJ; (2008) 'Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunohistochemical labeling'. Journal of Neuroscience Methods, . [Details]
Cumiskey, D, Curran, BP, Herron, CE, OConnor, JJ, ; (2007) 'A role for inflammatory mediators in the IL-18 mediated attenuation of LTP in the rat dentate gyrus'. Neuropharmacology, 52 :1616-1623. [Details]
O'Sullivan N.C., McGettigan P.A., Sheridan, G.K., Pickering, M., Conboy, L., O'Connor, J.J., Moynagh, P.N., Higgins, D.G., Regan, C.M., Murphy, K.J. ; (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. Journal of Neurochemistry, 101 (4):1085-1098. [Details]
O'Neill C., Nolan B., Macari A., O'Boyle K.M. and O'Connor J.J. ; (2007) 'Adenosine A1 receptor-mediated inhibition of dopamine release from rat striatal slices is modulated by D1 dopamine receptors'. European Journal of Neuroscience, 26 :3421-3428. [Details]
Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J. ; (2007) 'NFkB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations'. Learning Memory, 14 (8):525-532. [Details]
Pickering, M. & O¿Connor J.J. ; (2007) 'Cytokines and their effects in the dentate gyrus'. Progress in Brain Research, 163 :339-354. [Details]
Cumiskey D., Pickering M., O'Connor J.J. ; (2006) 'Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists'. Neuroscience Letters, 412 (3):206-210. [Details]
Cumiskey, D., Butler, M.P., Moynagh, P.N. & O'Connor, J.J. ; (2006) 'Evidence for a role for the group 1 metabotropic glutamate receptor in the inhibitory effect of tumour necrosis factor-a on long-term potentiation'. Brain Research, 1136 (1):13-19. [Details]
Pickering, M; Cumiskey, D; O'Connor, JJ (2005) 'Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system'. Experimental Physiology, 90 (5):663-670. [Details]
Butler, MP; O'Connor, JJ; Moynagh, PN (2004) 'Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP'. Neuroscience, 124 (2):319-326. [Details]
Murray, HJ; O'Connor, JJ (2004) 'A role for monomeric G-proteins in synaptic plasticity in the rat dentate gyrus in vitro'. Brain Research, 1000 (1-2):85-91. [Details]
Curran, BP; Murray, HJ; O'Connor, JJ; ; (2003) 'A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1 beta and long-term depression in the rat dentate gyrus in vitro'. Neuroscience, 118 (2):347-357. [Details]
Curran, B. & O'Connor, J.J. (2003) 'The inhibition of long-term potentiation by pro-inflammatory cytokines is attenuated in the presence of nicotine'. Neuroscience Letters, 344 :103-106. [Details]
Murray, HJ; O'Connor, JJ (2003) 'A role for COX-2 and p38 mitogen activated protein kinase in long-term depression in the rat dentate gyrus in vitro'. Neuropharmacology, 44 (3):374-380. [Details]
Butler, M., Moynagh, P. & O'Connor, J.J. (2002) 'Methods of detection of the transcription factor NF-kB in rat hippocampal Slices'. Journal of Neuroscience Methods, 119 (2):185-190. [Details]
Markos, F., Campion, D.P., Carey, M. & O'Connor, J.J.; (2002) 'An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue'. Respiration, 69 (4):339-343. [Details]
Griffin, MJ,Breen, PM,O'Connor, JJ,Hannon, V (2001) 'Desflurane, compared to halothane, augments phenylephrine-induced contraction in isolated rat aorta smooth muscle'. Canadian Journal of Anaesthesia, 48 :361-368. [Details]
Curran, B; O'Connor, JJ (2001) 'The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro'. Neuroscience, 108 (1):83-90. [Details]
Saleshando, G,O'Connor, JJ (2000) 'SB203580, the p38 mitogen-activated protein kinase inhibitor blocks the inhibitory effect of beta-amyloid on long-term potentiation in the rat hippocampus'. Neuroscience Letters, 288 :119-122. [Details]
Frizelle, H., Moriarty, D. & O'Connor, J.J. (2000) 'Effects of the combination of halothane and serotonin uptake blockers on synaptic transmission in the rat dentate gyrus in vitro'. Journal of Basic and Clinical Physiology and Pharmacology, 11 (1):29-45. [Details]
Coogan, AN,O'Connor, JJ (1999) 'Interleukin-1 beta inhibits a tetraethylammonium-induced synaptic potentiation in the rat dentate gyrus in vitro'. European Journal of Pharmacology, 374 :197-206. [Details]
O'Leary, D.M. & O'Connor, J.J. (1999) 'Potentiation of synaptic transmission by (s)-3,5-dihydroxyphenylglycine in the rat dentate gyrus in vitro: role of voltage dependant calcium channels and protein kinase C'. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 23 (1):133-147. [Details]
Frizelle, H., Moriarty, D. & O'Connor, J.J.; (1999) 'Combined effects of halothane & lamotrigine on excitatory post synaptic potentials & use dependent block in vitro'. Anesthesia and Analgesia, 89 (2):496-501. [Details]
O'Connor, J.J. & Coogan, A. (1999) 'Actions of the pro-inflammatory cytokine IL-1beta on central synaptic transmission'. Experimental Physiology, 84 (4):601-614. [Details]
Coogan, AN; O'Neill, LAJ; O'Connor, JJ (1999) 'The p38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1 beta on longterm potentiation in the rat dentate gyrus in vitro'. Neuroscience, 93 (1):57-69. [Details]
Coogan, AN,O'Leary, DM,O'Connor, JJ; (1999) 'P42/44 MAP kinase inhibitor PD98059 attenuates multiple forms of synaptic plasticity in rat dentate gyrus in vitro'. Neurophysiology, 81 :103-110. [Details]
O'Leary, D.M. & O'Connor, J.J.; (1998) 'Priming of long-term potentiation by prior activation of group I and II metabotropic glutamate receptors in the rat dentate gyrus in vitro'. Brain Research, 809 (1):91-96. [Details]
O'Leary, DM,Cassidy, EM,O'Connor, JJ; (1997) 'Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro'. European Journal of Pharmacology, 340 :35-44. [Details]
McGuire, M., Carey, M.F. & O'Connor, J.J.; (1997) 'Almitrine and doxapram decrease the degree of fatigue of twitch tension and increase subsequent recovery in isolated diaphragh muscle fibres'. Journal of Applied Physiology, 83 (1):52-58. [Details]
O'Leary, D.M. & O'Connor, J.J.; (1997) 'Potentiation of synaptic transmission in the rat dentate gyrus in vitro by (S)-3,5-dihydroxy phenylglycine (S)-DHPG'. Neuroscience Letters, 229 :29-32. [Details]
Coogan, A. & O'Connor J.J.; (1997) 'Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1beta'. NeuroReport , 8 (9):2107-2110. [Details]
Cunningham, AJ,Murray, CA,ONeill, LAJ,Lynch, MA,OConnor, JJ; (1996) 'Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro'. Neuroscience Letters, 203 :17-20. [Details]
Kruk, Z.L. & O'Connor, J.J. ; (1995) 'Fast electrochemical studies in isolated tissues'. Trends in Pharmacological Sciences, 16 :145-149. [Details]
O'Connor, J.J., Rowan, M.J. and Anwyl, R.; (1995) 'Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current: investigations of the involvement of mGlu receptors'. Neuroscience, 15 (3):2013-2020. [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R; (1995) 'Potentiation of N-Methyl-D-Aspartate-receptor-mediated currents detected using the excised patch technique in the hippocampal dentate gyrus'. Neuroscience, 69 (2):363-369. [Details]
O'Connor, J.J., Rowan, M.J. and Anwyl, R.; (1994) 'Long-lasting enhancement of NMDA-receptor mediated synaptic transmission by metabotropic glutamate receptor activation'. Nature, 367 :557-559. [Details]
O'Connor, J.J. & Kruk, Z.L.; (1994) 'Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro'. Brain Research, 640 :328-335. [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R.; (1993) 'Use-dependent effects of acute and chronic treatment with imipramine and buspirone on excitatory synaptic transmission in the rat hippocampus in vivo'. Naunyn - Schmeideberg Archives of Pharmacology, 348 :158-163. [Details]
Millar, J., O'Connor, J.J., Trout, S.J. & Kruk, Z.L.; (1992) 'Continuous scan cyclic voltammetry (CSCV); a new high speed electrochemical method for monitoring neuronal dopamine release'. Journal of Neuroscience Methods, 43 :109-118. [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R.; (1992) 'Serotoninergic depression of auditory evoked responses recorded in the rat hippocampus: effect of repeated buspirone treatment'. Brain Research, 573 :190-196. [Details]
O'Connor, J.J. & Kruk, Z.L.; (1992) 'Pharmacological characteristics of 5-hydroxytryptamine autoreceptors in rat brain slices incorporating the dorsal raphe or the suprachiasmatic nucleus'. British Journal of Pharmacology, 106 :524-532. [Details]
Stamford, J.A., Muscat, R., O'Connor, J.J., Patel, J., Trout, S.J., Wieczorek, W., Kruk, Z.L. & Willner, P.; (1991) 'Voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine'. Psychopharmacology, 105 :275-282. [Details]
O'Connor, J.J. & Kruk, Z.L. (1991) 'Frequency dependence of 5-HT autoreceptor function in rat dorsal raphe and suprachiasmatic nuclei studied using fast cyclic voltammetry'. Brain Research, 568 :123-130. [Details]
O'Connor, J.J. & Kruk, Z.L.; (1991) 'Fast cyclic voltammetry can be used to measure stimulated endogenous 5-hydroxytryptamine release in rat brain slices'. Journal of Neuroscience Methods, 38 :25-33. [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R.; (1990) 'Actions of 5-HT1A receptor ligands on excitatory synaptic transmission in the hippocampus of alert rats'. British Journal of Pharmacology, 101 :171-177. [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R.; (1989) 'Serotonergic involvement in the inhibitory effects of repeated buspirone treatment on synaptic transmission in the hippocampus'. European Journal of Pharmacology, 167 :21-29. [Details]
Rowan, M.J., O'Connor, J.J. & Anwyl, R.; (1988) 'Changes in auditory evoked responses and in the inhibitory action of 5-hydroxytryptophan following chronic treatment with imipramine in the rat'. Psychopharmacology, 96 :408-413. [Details]
 

Conference Publications

Beirne E., Campion, D.P., O¿Connor J.J. (2017) Differential effects of atropine on carbochol-evoked contractions in rat proximal and distal colon Royal Academy of Medicine in Ireland Biomedical Sciences Section [Details]
Rebecca A Fanning, Deirdre P Campion, Maeve O¿Shea, Michael F Carey, John J. O¿Connor (2017) A Comparison of the Effects of lindane and FeCl3/ADP on Spontaneous Contractions in Isolated Rat or Human Term Myometrium Annual Meeting of the British Pharmacological Society (BPS) [Details]
Laningan, S, O¿Connor J.J. (2017) Protocatechuic acid ethyl ester (EDHB) reduces synaptic transmission and long-term potentiation in the isolated rat hippocampus Section of Biomedical Sciences, UCC meeting [Details]
Wall, A.M., Mukandala, G., O'Connor, J.J. (2016) A novel role for tumor necrosis factor-A in synaptic plasticity after acute hypoxia in the rat dentate gyrus Section of Biomedical Sciences, UCD meeting 2014 [Details]
Lannigan S, O¿Connor JJ. (2016) The effects of the hypoxia mimetic protocatechuic acid ethyl ester on cell viability and synaptic plasticity in rat hippocampal slices British Pharmacological Society Annual Meeting [Details]
Lannigan S, O¿Connor JJ. (2016) The acute effects of the hypoxia mimetic protocatechuic acid ethyl ester on synaptic transmission and plasticity in the rat hippocampus Physiological Society [Details]
Mukandala, G., Wall, A.M., O¿Connor, J.J. (2015) The effects of thalidomide analogues on synaptic plasticity after acute hypoxia in the rat hippocampus are modulated by p38map kinase but not cox-2 inhibition Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences Meeting, UCD [Details]
Mukandala, G., Wall., A.M., O'Connor J.J. (2014) The effects of thalidomide analogues on synaptic plasticity after acute hypoxia in the rat hippocampus are modulated by p38map kinase but not cox-2 inhibition Section Biomedical Sciences, RAMI [Details]
A. Wall, A.E. Corcoran, K. O'Halloran, J.J. O' Connor (2014) Effects of chronic intermittent hypoxia and prolyl-hydroxylase inibition on synaptic transmission and plasticity in the rat ca1 and dentate gyrus Section of Biomedical Sciences, RAMI, UCC Cork, [Details]
C. Leyden, R.A. Fanning, D.P. Campion, J.J. OConnor (2013) A novel role for adrenergic and serotonergic signaling in the action of ergometrine in isolated term human myometrium Section of Biomedical Sciences, RAMI, UCC Cork, , 20-JUN-13 - 21-JUN-13 [Details]
Alan E. Corcoran, John J. OConnor (2013) Acute hypoxic pre-conditioning and prolyl-hydroxylase inibition improves synaptic transmission recovery time from a subsequent hypoxic insult in the rat hippocampus Section of Biomedical Sciences, RAMI, UCC Cork, , 20-JUN-13 - 21-JUN-13 [Details]
Luke M. Alvey, John J. OConnor (2013) Novel interactions of succinate, lipopolysaccharide and hypoxia on synaptic transmission in the rat hippocampus in vitro Section of Biomedical Sciences, RAMI, UCC Cork, , 20-JUN-13 - 21-JUN-13 [Details]
Audrey M. Wall, Gatambwa Mukandala, John J. O'Connor. (2013) A novel role for tumor necrosis factor-α in synaptic plasticity after acute hypoxia in the rat dentate gyrus Irish Journal of Medical Sciences Volume 183 [Details]
O¿Connor JJ (2013) A new role for prolyl hydroxylase in synaptic signalling British Neuroscience Association [Details]
H. Nolan, A.E. Corcoran, J.J. O'Connor (2013) The effects of hypoxia-mimetic drugs on synaptic transmission and synaptic plasticity in the dentate gyrus in vitro Section of Biomedical Sciences, RAMI, UCC Cork, , 20-JUN-13 - 21-JUN-13 [Details]
Corcoran, A.E., Kunze, R., Harney, S.C., Breier, G., Marti, H.H., and OConnor, J.J. (2013) A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity Hypoxianet, Oulu Oulu, Finland, [Details]
Fanning RA, Duffy N, Leonard M, Ahmed JJ, O'Connor JJ (2012) An investigation into the effects of ergometrine on human myomterium in vitro International Society of Obstetric Anaesthesia [Details]
Mukandala GD, O'Connor, JJ (2012) TNF-α synthesis inhibition post hypoxia impairs long-term potentiation in the dentate gyrus in vitro FENS Barcelona [Details]
Wall AM, O'Connor JJ (2012) Tumour necrosis factor alpha does not impair long term potentiation following an acute hypoxic insult FENS Barcelona [Details]
Corcoran AE, Harney SC, O'Connor JJ (2012) Prolyl hydroxylase inhibition impairs long-term potentiation in the rat hippocampus FENS Barcelona [Details]
Fanning RA, McMorrow JP, Campion DP, Carey MF, O'Connor JJ (2012) Opioid mediated activity in human term non-laboring myometrium Section of Biomedical Sciences, RAMI, NUIG Galway, [Details]
Fanning RA, Duffy N, Leonard M, Ahmed JJ, O'Connor JJ (2012) The oxytocic effect of ergometrine on human myomterium in vitro does not involve 5-HT2 receptor activation Section of Biomedical Sciences, RAMI, NUIG Galway, [Details]
Mukandala, G., O'Connor, J.J. (2012) 3,6-Dithiothalidomide, the TNF-α synthesis inhibitor applied pre-hypoxia, impairs long-term potentiation in the rat dentate gyrus in vitro Section of Biomedical Sciences, RAMI, NUIG [Details]
Sheridan GK, Pickering M, Watters O, Halley PG, O'Sullivan NC, Mooney C, O'Connor JJ, Murphy KJ (2012) CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity Society for Neuroscience Annual Meeting 2012 [Details]
Corcoran AE, O'Connor JJ (2011) Dimethyloxalyl Glycine Decreases Synaptic Signalling and Impairs Long Term Potentiation in the Rat Hippocampus Neuroscience Ireland Annual meeting NUI Maynooth Irish Journal of Medical Science, [Details]
Wall AM, O'Connor JJ (2011) Acute hypoxia impairs the recovery of synaptic transmission in the rat dentate gyrus and potentiates long-term potentiation in the presence of tumour necrosis factor-alpha and picrotoxin Neuroscience Ireland Annual meeting NUI Maynooth Irish Journal of Medical Science, [Details]
Corcoran AE, O'Connor JJ (2011) Acute effects of hypoxia and prolyl hydroxylase inhibition on synaptic plasticity in the rat hippocampus Soc Neuroscience [Details]
Corcoran, A.E., O¿Connor, J.J. (2011) The effects of hypoxia and PHD inhibition on synaptic transmission in the rat hippocampus Hypoxianet, Davos Davos, Switzerland, [Details]
O'Connor JJ, Dalton M, Cavanni P, Large CH, Lowry JP (2011) A comparison of the effects of the dopamine partial agonists aripiprazole and (-)- 3-PPP with quinpirole on stimulated dopamine release in the rat striatum: studies using fast cyclic voltammetry in vitro Neuroscience Ireland Annual meeting NUI Maynooth Irish Journal of Medical Science, [Details]
Watters O, O'Connor JJ ; (2010) TNF-α And Glutamate preconditioning attenuates calcium mediated activity in the ca region of rat organotypic hippocampal cultures Neuroscience Ireland meeting UCD (Sept) Irish Journal of Medical Science [Details]
Corcoran A.E., O'Connor JJ; (2010) Acute effects of proyly hydroxylase inhibition on synaptic transmission and plasticity in the rat hippocampal slice RCSI June, Irish Journal of Medical Science [Details]
Sheridan, G.K., Pickering, M., O'Connor, J.J., Moynagh, P.N., Murphy, K.J. ; (2010) Similar temporal oscillations in hippocampal NF-kB following spatial learning in rats and high-frequency stimulation of organotypic slice cultures Neuroscience Ireland Meeting, TCD. Irish Journal of Medical Science [Details]
Sheridan, G.K., Pickering, M., O'Connor, J.J., Moynagh, P.N., Murphy, K.J. ; (2010) Similar temporal oscillations in hippocampal NF-kB following spatial learning in rats and high-frequency stimulation of organotypic slice cultures Neuroscience Ireland Meeting [Details]
Sheridan, G.K., Pickering, M., Halley, P., O'Sullivan, N.C., O'Connor, J.J., Murphy, K.J. ; (2010) The chemokine, fractalkine (CX3CL1), modulates synaptic plasticity and is upregulated in the rat hippocampus following a spatial learning task Neuroscience Ireland Meeting [Details]
Batti, L., Taylor, C., O'Connor, J.J. ; (2010) A role for the prolyl hydroxylase inhibitor, DMOG, on synaptic transmission and neuroprotection in an ex vivo model of cerebral ischaemia Neuroscience Ireland Meeting [Details]
Corcoran A, O'Connor JJ; (2010) The effects of hypoxia, prolyl hydroxylase inhibition and TNF-alpha on synaptic transmission in the rat hippocampus Winter Meeting British Pharmacology Society [Details]
Watters O, O'Connor JJ; (2010) TNF-a And Glutamate Preconditioning Effects On Calcium Dynamics In Rat Hippocampal Cultures Winter Meeting British Pharmacology Society [Details]
Corcoran AE, O'Connor JJ; (2010) Acute effects of prolyl hydroxylase inhibiton on synaptic transmission and plasticity in the hippocampal rat slice Royal Academy of medicine in Ireland Biomedical sciences section annual meeting 2010 [Details]
Watters O, O'Connor JJ; (2010) Modulatory effects of TNFalpha and glutamate pretreatment on calcium homeostasis and glutamate-induced calcium influx in rat organotypic hippocampal cultures Royal academy of medicine in Ireland biomedical sciences section annual meeting 2010 [Details]
Watters O, O'Connor JJ; (2010) Modulatory effects of TNFα and glutamate pretreatment on calcium homeostasis and glutamate-induced calcium influx in rat organotypic hippocampal cultures Neuroscience Ireland 2010 [Details]
Corcoran AE, O'Connor JJ; (2010) Acute effects of prolyl hydroxylase inhibiton on synaptic transmission and plasticity in the rat hippcampal slice Neuroscience Ireland 2010 [Details]
Sheridan GK, Pickering M, O¿Connor JJ, PN Moynagh and Murphy KJ (2009) Similar temporal oscillations in hippocampal NF-κB following spatial learning in rats and high frequency stimulation of organotypic slice cultures Neuroscience Ireland [Details]
Sheridan GK, Pickering M, Halley P, O¿Sullivan NC, O¿Connor JJ and Murphy KJ (2009) The chemokine, fractalkine (CX3CL1), modulates synaptic plasticity and is upregulated in the rat hippocampus following a spatial learning task Neuroscience Ireland [Details]
Alison L Reynolds, Ross F Collery, Maria L Cederlund, John J O¿Connor, Breandán N Kennedy; (2009) Electroretinography of a novel zebrafish model of human cone rod dystrophy 6 European Retina Meeting [Details]
Watters, O., O¿Connor J.J. ; (2009) Modulatory effects of TNFα and glutamate pretreatment on calcium homeostasis and glutamate-induced calcium influx in rat organotypic hippocampal cultures American Society for Neuroscience, Chicago [Details]
Batti L., Taylor C.T. & O¿Connor J.J. ; (2009) Modulatory actions of TNF-α on synaptic transmission during hypoxia in the rat hippocampus British Neuroscience Association, Liverpool [Details]
Watters O., O¿Connor J.J., ; (2009) Effects of TNF-α and glutamate pre-treatment on glutamate-induced calcium influx in rat organotypic hippocampal cultures British Neuroscience Association, Liverpool [Details]
Batti L., Taylor C.T. & O¿Connor J.J. ; (2009) Modulation of synaptic transmission by TNF-α after hypoxic exposure in rat hippocampal slices Procedings of the Physiological Society [Details]
Watters O., O¿Connor J.J. ; (2009) Effects of tumour necrosis factor-α and glutamate pretreatment on glutamate-induced calcium influx in rat organotypic hippocampal cultures Procedings of the Physiological Society [Details]
Watters, O., O¿Connor, J.J. ; (2009) Modulatory effects of TNFα and glutamate pretreatment on calcium homeostasis and glutamate-induced calcium influx in rat organotypic hippocampal cultures Neuroscience Ireland 2009 [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2009) A role for the prolyl hydroxylase inhibitor, DMOG, on synaptic transmission and neuroprotection in an ex vivo model of cerebral ischaemia Neuroscience Ireland 2009 [Details]
Batti L., Taylor C.T. & O¿Connor J.J. ; (2008) A role for adenosine receptors in hypoxia in rat hippocampal slices J. Neuroimmunology, Vol. 197, page 171 [Details]
Reynolds A.L., O¿Connor J.J., Humphries P. ; (2008) Strain-specific differences in hippocampal neurotransmission in isolated C57BL/6JOlaHsd and 129S2/SvHsd mouse brain slices Irish journal of Medical Science [Details]
Batti, L., Taylor, C., Sheridan, G., O¿Connor, J.J. ; (2008) Hippocampal CA1 and granule cells respond differentially to mild hypoxia: roles for HIF-1α and NF-κB Irish journal of Medical Science [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) An investigation into the role of adenosine A1 receptors in hippocampal LTP after exposure to mild hypoxia Irish Journal of Medical Science [Details]
Watters O., O¿Connor J.J., Sheridan G.K., Murphy K.J. & Pickering M. ; (2008) Modulation of glutamate excitotoxicity and ischemic pre-conditioning by TNFα depends on time and order of TNFα and glutamate exposure J. Neuroimmunology, Vol. 197, page 171 [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) Differential responses to hypoxia in the rat hippocampus CA1 and dentate gyrus regions in vitro Biosymposia; Hypoxia, Ischemia, and inflammation, Boston, USA [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) Effects of mild hypoxic exposure in rat hippocamal slices: role for adenosine A1 receptors in the maintenance of LTP Biosymposia; Hypoxia, Ischemia, and inflammation, Boston, USA [Details]
Batti, L., Taylor, C., O¿Connor, J.J. ; (2008) Effects of mild hypoxic exposure in rat hippocamal slices: role for adenosine A1 receptors in the maintenance of LTP American Society for Neuroscience [Details]
Batti, L., Taylor, C., Sheridan, G., Herron, C.E., O¿Connor, J.J. ; (2008) Differential responses to hypoxia in the rat hippocampus CA1 and dentate gyrus regions in vitro American Society for Neuroscience [Details]
Watters, O., O¿Connor, J.J. ; (2008) A comparison of the timecourse of glutamate-induced calcium influx in rat organotypic hippocampal cultures using manual and image software analysis Irish journal of Medical Science [Details]
O'Connor JJ, Watters O, Sheridan GK, Murphy KJ & Pickering M; (2007) TNFalpha-mediated modulation of glutamate excitotoxicity and ischemic preconditioning is time and sequence of TNFalpha and glutamate exposure-dependent Society for Neuroscience Annual Meeting 2007 [Details]
Sheridan, G. K., Pickering, M., Moynagh, P. N., O'Connor, J. J., Murphy, K. J. (2007) Temporal changes in nuclear factor-kappa B activity in distinct neuronal subpopulations of the rat hippocampus following spatial learning Society for Neuroscience [Details]
O'Connor JJ, Watters O, Sheridan GK, Murphy KJ & Pickering M. ; (2007) Modulation of glutamate excitotoxicity and ischemic preconditioning by TNFα depends on time and order of TNFα and glutamate exposure Society for Neuroscience [Details]
Cumiskey, D., O'Connor, J.J. (2006) The role of metabotropic glutamate receptors in the inhibitory effect of interleukin-18 on long-term potentiation Irish journal of Medical Science, Volume 175(3) [Details]
O'Neill C., Nolan B., O'Boyle K.M. and O'Connor J.J. ; (2006) SCH23390 attenuates A1 receptor-mediated inhibition of electrically evoked dopamine release from rat striatal slices British Journal of Pharmacology. Vol 3, Issue 4, 067P [Details]
O'Leary D.M., Grennan G.Z., O'Connor J.J. and Herron C.E.; (2006) The role of arachidonic acid signalling in mGluR mediated long term depression in the rat hippocampus British Journal of Pharmacology, Vol 3, Issue 4, 152P [Details]
Sheridan G., Pickering M., Moynagh P.N., O'Connor J.J. and Murphy K.J.; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations British Journal of Pharmacology, Vol 3, Issue 4, 113P [Details]
Cumiskey, D., O' Connor, J.J.; (2006) A role for mGluRs and Ca2+ in the inhibitory effect of tumour necrosis factor-a on long-term potentiation British Journal of Pharmacology. Vol 3, Issue 4, 055P [Details]
Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J.; (2006) GABA receptor blockade increases NFκb activation in neuroplastic cells of the rat dentate gyrus while decreasing its activity in more mature granule neurons Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) [Details]
Pickering, B.W., Pickering, M., O'Connor, J.J., Murphy, K.J. ; (2006) The anaesthetic agents propofol and isoflurane differentially effect glutamate-induced calcium influx in primary cultured neurones and glia Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) [Details]
Pickering, M., Pickering, B.W., Murphy, K.J., O'Connor, J.J. ; (2006) Discrimination of neurones and glia using calcium imaging in primary mixed cell culture models of glutamate excitotoxicity Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) [Details]
Sheridan, G., Pickering, M., Moynagh, P.N., O'Connor, J.J. and Murphy, K.J.; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations Royal Academy of Medicine in Ireland, Section of Biomedical Sciences UCD, , 12-JAN-06 [Details]
Evers-Donnelly, A., O'Neill, C., O'Boyle, K., O'Connor, J.J. ; (2006) Modulation of dopamine release by cannabinoid receptor activation in rat striatal slices Irish journal of Medical Science, Volume 175(3) (electronic supplement 1), p41 [Details]
Herron, C., Grennan G., Dolan C., O'Connor J., O'Leary D. ; (2006) Metabotropic Glutamate Receptor Dependent Long-Term Depression in the Hippocampus: Involvement of Endocannabinoid Signaling via TRPV1 16th Annual Symposium on the Cannabinoids, June 26th. Tihany, Hungary [Details]
O¿Neill C, B. Nolan, K. O¿Boyle, J. J. O¿Connor (2005) Modulation of dopamine release by adenosine in the rat striatum in vitro: studies using fast cyclic voltammetry Section of Biomedical Sciences, RAMI, NUIG Galway, [Details]
O¿Leary D., Grennan GZ, O¿Connor, JJ and Herron, CE. ; (2005) Inhibition of DHPG induced LTD in the hippocampal CA1 in vitro European Brain and Behaviour Society 37th Annual Meeting, TCD [Details]
Cumiskey, D., O' Connor, J.J. (2005) A role for group 1 mGluR in the inhibitory effect of tumour necrosis factor-α on long-term potentiation Section of Biomedical Sciences, RAMI, NUIG [Details]
O'Neill, C & O'Connor J.J.; (2004) Fast cylic voltammetric evidence that TNF-a does not inhibit electrically evoked dopamine release in rat striatum in vitro Irish journal of Medical Science, Volume 173 (electronic supplement 2) [Details]
Campion D.P, Houset C, Kamdar S, Carey M, Briggs, L. & O'Connor JJ. (2004) A possible role for ATP-sensitive k+ channels in the effect of ketamine on isolated human myometrium Irish journal of Medical Science, Volume 173 (electronic supplement 2) [Details]
Cumiskey, D & O'Connor J.J. (2004) Evidence for a role of mglur1 in the inhibitory effect of tumour necrosis factor-a on long-term potentiation Irish journal of Medical Science, Volume 173 (electronic supplement 2) [Details]
O'Neill, C & O'Connor J.J. ; (2004) Tumour necrosis factor-a does not affect evoked dopamine release and reuptake in the rat striatum in vitro, Journal of Physiology Journal of Physiology. Volume 560P, C51 [Details]
Cumiskey, D, Butler MP, Moynagh PN & O'Connor JJ. ; (2004) The inhibitory effect of tumour necrosis factor-a on long-term potentiation is attenuated by type 1 metabotropic glutamate receptor blockade Journal of Physiology, Volume 560P, C23 [Details]
Shouldice, C. & O'Connor J.J. (2003) Effect of reactive oxygen species producers on human term isolated myometrium Irish journal of Medical Science, 172(2), suppl 2 [Details]
Campion, D.P., C. Wrixon, E Quinn, L. Briggs, M. Carey, J.J. O'Connor. (2003) Rho-kinase involvement in spontanous and oxytocin-induced human myometrial contractions Irish journal of Medical Science, Volume 172 (electronic supplement 2) [Details]
Cumiskey, M.P. Butler, P.N. Moynagh & J.J. O'Connor (2003) An investigation into the effect of putative NFkb inhibitors on LTP in the rat dentate gyrus in vitro Irish journal of Medical Science, Volume 172 (electronic supplement 2) [Details]
O'Connor, J.J. & Curran, B.P. Nicotine ; (2003) The inhibitory effects of pro-inflammatory cytokines on LTP are attenuated by nicotine Journal of Physiology. 548P, P141 [Details]
Murray, H. & O'Connor, J.J. ; (2001) A role for cyclooxygenase in the inhibitory effect of IL-1b on long term potentiation in isolated slices of the rat dentate gyrus Journal of Physiology, 531P, 109 [Details]
Cronin, D., McHale, J., Moriarty, D., Herron, C. & O'Connor, J.J. (2001) Measurement of sevofluorane in artificial cerebrospinal fluid by gas chromatography headspace analysis Irish journal of Medical Science, 170(3) [Details]
Curran, B.P. & O'Connor, J.J.; (2001) The impairment of long-term potentiation by the novel pro-inflammatory cytokine interleukin-18 is attenuated by prior application of the interleukin-1 receptor antagonist in the rat dentate gyrus in vitro Journal of Physiology (Lond Meeting), 531P, 110 [Details]
Butler, M., O'Connor J.J. & Moynagh, P. ; (2001) An evaluation of the efects of TNF-a on long term potentiation in the rat dentate gyrus in vitro British Journal of Pharmacology, 134, 10P [Details]
Murray, H. & O'Connor, J.J.; (2001) An inhibitory role for cyclooxygense-2 in long term depression in the rat dentate gyrus in vitro British Journal of Pharmacology, 134, 7P [Details]
Murray, H. & O'Connor, J.J. (2000) The ras inhibitor manumysin a partially attenuates the inhibitory effect of IL-1b on tetanic induced long-term potentiation Irish journal of Medical Science, 169(4) [Details]
O'Connor, J.J., Carey, M., & McGarrigle, D. (2000) NI2+ increases oxytocin-induced contracture amplitude and inhibits spontaneous-induced contractile frequency in isolated term human myometrium Irish journal of Medical Science, 169(4) [Details]
Curran, B.P. & O'Connor, J.J.; (2000) The novel pro-inflammatory cytokine, IL-18, inhibits long-term potentiation in the rat dentate gyrus in vitro Irish journal of Medical Science. 169(4) [Details]
Quinn, A., McHale, J., Moriarty, D. & O'Connor, J.J. ; (2000) An investigation into the effects of sevoflurane and calcium channel blockers on field evoked excitatory post synaptic potentials in the rat hippocampus in vitro Irish journal of Medical Science. 169(4) [Details]
Saleshando, G. and O'Connor, J.J. (1999) A role for the p38 map kinase in the inhibitory effect of b-amyloid on long-term potentiation in the rat hippocampus in vitro Irish journal of Medical Science, 168(4) [Details]
Ryan, M, Marsh, B., Moriarty, D. & O'Connor, J.; (1999) Differential efects of prostacyclin and s-nitrosopenicillamine on rat airway smooth muscle in vitro Anesthesia & Analgesia, 88(2), S424 [Details]
Frizelle, H.P., O'Connor, J.J., & Moriarty, D.C.; (1999) Combined effects of halothane and lamotrigine on excitatory post synaptic potentials and use dependent block in the rat hippocampus in vitro Anesthesia & Analgesia, 88(2), S333 [Details]
Hölscher, C and O'Connor, J.J.; (1999) b-amyloid fragment [25-35] impairs synaptic transmission in chronic recordings of field potentials Journal of Physiology, 515, 53-54p [Details]
Campion, D.P., and O'Connor, J.J.; (1999) Lipopolysaccaride inhibits k+- but not caffeine-induced contractures in the rat diaphragm muscle in vitro Irish Journal of Medical Science, 168(2) [Details]
Frizelle, H.P., Moriarty D.C., O'Connor, J.J. (1999) Combined effects of halothane, progesterone and 17-b oestradiol on synaptic transmission in the rat hippocampus in vitro Irish journal of Medical Science, 168(4) [Details]
Curran, B.P., O'Neill, L.A.J. and O'Connor, J.J. (1999) Evidence for a role of c-jun n-terminal kinase in mediating the inhibitory effect of IL-1b on LTP in the rat dentate gyrus in vitro Irish journal of Medical Science, 168(4) [Details]
Dunne, E.M., O'Connor, J.J. and Herron, C.E. (1999) Nicotine modulates synaptic transmission in the rat dentate gyrus in vitro Irish journal of Medical Science, 168(4) [Details]
Glennon, J.C. O'Connor, J.J. and O'Connor, W.T.; (1998) Medial prefrontal cortex GABA regulates local and striatal dopamine and GABA release as studied by dual probe microdialysis in the conscious rat Journal of Physiology, 511, 69-70p [Details]
Coogan, A. and O'Connor, J.J. (1998) A requirement for a map kinase cascade in the expression of a tetraethylammonium-induced synaptic potentiation in the rat dentate gyrus in vitro Irish Journal of Medical Science,168 (1), 69p [Details]
Frizelle, H.P., O'Connor, J.J., & Moriarty, D.C.; (1998) Effects of halothane and lidocaine on field evoked excitatory post synaptic potentials and use dependent block in the rat brain in vitro Anesthesia & Analgesia, 86, S444 [Details]
Coogan, A. and O'Connor, J.J. ; (1998) Interleukin-b inhibits a tetraethylammonium-induced synaptic potentiation in the rat dentate gyrus in vitro British Journal of Pharmacology, 125, 34p [Details]
Glennon, JC; O'Connor, JJ; O'Connor, WT (1998) Medial prefrontal cortex GABA regulates local and striatal dopamine and GABA release, as studied by dual probe microdialysis in the conscious rat Physiological Society London Meeting [Details]
Coogan, A., O'Neill, L.A.J. & O'Connor, J.J. (1998) A requirement for a mitogen-activated protein kinase cascade in long-term potentiation in the rat dentate gyrus in vitro Irish Journal of Medical Science, 167, 204 [Details]
Carey, M, Rogers, P., O'Connor, J.J. (1998) Does nitric oxide play a role in the contractility of term human uterine muscle? Irish Journal of Medical Science, 168 (1), 71p [Details]
O'Leary, D.M. & O'Connor, J.J. (1998) Inhibition of (S)-3,5-dihydroxy phenylglycine-induced potentation of synaptic transmission by broad sprectum protein kinase C (PKC) inhibitors in the rat hippocampus in vitro Irish Journal of Medical Science, 167, 204 [Details]
Walsh A.-M., & O'Connor, J.J. (1998) Effect of mGluR agonists on paired pulse stimulation in the lateral perforant path of the rat hippocampus in vitro Irish Journal of Medical Science, 167, 199 [Details]
O'Leary, D.M. & O'Connor, J.J.; (1997) Effects of type I and II metabotropic glutamate receptor agonists and antagonists on paired pulse depression in the rat dentate gyrus in vitro British Journal of Pharmacology, 120, 31p [Details]
O'Leary, D.M. & O'Connor, J.J.; (1997) Potentation of synaptic transmission in the rat dentate gyrus in vitro by the type I metabotropic glutamate receptor agonist (S)-3,5-dihydroxyphenylglycine (DHPG) Journal of Physiology, 501, 90-91p [Details]
Coogan, A. O'Neill, LAJ & O'Connor, J.J. ; (1997) The p38 MAP kinase inhibitor, SB203580, antagonises the inhibitory effect of IL-1b on long-term potentiation in the rat dentate gyrus in vitro Journal of Physiology, 501, 86-87p [Details]
Galvin, C. & O'Connor, J.J. (1997) Effect of lipopolysaccaride and IL-1b on different modes of contraction of rat diaphragm muscle in vitro Irish Journal of Medical Science, 166(3) 174p [Details]
Markos, F., Carey, M.F. & O'Connor, J.J. (1997) Effect of almitrine and n-acetylycysteine on rat diaphragm twitch tension and recovery from fatigue in vitro Irish Journal of Medical Science, 166(3) 174p [Details]
Coogan, A. & O'Connor, J.J. (1997) The inhibitory effects of IL-1β on LTP in the rat dentate gyrus in vitro, may be through inhibition of NMDA receptor activation Irish Journal of Medical Science, 166, 252p [Details]
O'Leary, D.M. & O'Connor, J.J. (1997) The induction of LTP occludes the modulatory role of mGluRs on early phase paired pulse depression in the rat dentate gyrus in vitro Irish Journal of Medical Science, 166, 250p [Details]
O'Leary, D.M. & O'Connor, J.J. (1996) MAP4 does not antagonise the attenuating effect of L-AP4 on early paired pulse depression in the rat hippocampus in vitro Irish Journal of Medical Science, 165(4), 314p [Details]
Cassidy, E. & O'Connor, J.J. (1996) The effects of presynaptic metabotropic glutamate receptors on paired pulse depression in the rat hippocampus in vitro Irish Journal of Medical Science, 165(3); 230p [Details]
McCrory, C., O'Connor, J.J., Boylan, J. & Hannon, V (1996) Effects of desflurane and halothane on isolated rat aortic smooth muscle Anesthesia & Analgesia USA, [Details]
O'Neill, J., Moynagh, P., O'Neill, L.A.J. & O'Connor, J.J. (1996) Preliminary studies into single channel currents in the neuroblastoma SK-N-SH cell line Irish Journal of Medical Science, 164(4), 317P [Details]
Cunningham, A., O'Neill, L.A.J. & O'Connor J.J. (1996) Inhibition of long-term potentiation by tumour necrosis factor in the rat dentate gyrus in vitro Physiological Society UK [Details]
McGuire, M., Carey, M.F. & O'Connor, J.J. (1996) The effect of chemoreceptor stimulants on the degree of fatigue and subsequent recovery in isolated diaphragm muscle from young and mature rats Physiological Society UK [Details]
Cassidy, E. & O'Connor, J.J. (1995) Effects of metabotropic glutamate receptors on paired pulse depression in the rat dentate gyrus in vitro British Journal of Pharmacology [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1994) Involvement of metabotropic glutamate and NMDA receptors in the induction of LTP of AMPA and NMDA receptor-mediated synaptic transmission Journal of Physiology, 479, 45P [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1993) Long-lasting potentiation of the NMDA receptor-mediated EPSC is inhibited by metabotropic receptor antagonists in rat dentate granule cells in vitro Journal of Physiology 473, 170P [Details]
O'Connor, J.J., Trout, S.J. & Kruk, Z.L. (1993) Modulation of stimulated 5-hydroxytryptamine overflow in slices of the dorsal raphe nucleus of the guinea-pig studied using fast cyclic voltammetry British Journal of Pharmacology, 108, 85P [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1993) Potentiation of NMDA receptor-mediated excitatory postsynaptic currents following metabotropic glutamate activation and tetanic stimulation in rat hippocampus Journal of Physiology, 473; 47P [Details]
Millar, J., O'Connor, J.J., Trout, S.J. & Kruk, Z.L. (1992) 100Hz sampling of the kinetics of dopamine release and reuptake in rat nucleus accumbens using continuous scan cyclic voltammetry (CSCV) Journal of Physiology, 452, 38P [Details]
O'Connor, J.J. & Kruk, Z.L (1992) Effects of 21 days fluoxetine on 5-HT autoreceptor function in the rat dorsal raphe and suprachiasmatic nucleus in vitro British Journal of Pharmacology, 107, 9P [Details]
O'Connor, J.J., Trout, S.J. & Kruk, Z.L. (1992) Modulation of stimulated 5-hydroxytryptamine overflow in slices of the dorsal raphe nucleus of the guinea-pig studied using fast cyclic voltammetry Irish Journal of Medical Science, 161(11), 640p [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1992) Whole cell patch clamp recording of excitatory synaptic transmission in rat hippocampal slices Irish Journal of Medical Science, 161(11), 648p [Details]
O'Connor, J.J. & Kruk, Z.L. (1991) Frequency dependence of 5-HT autoreceptor function in rat dorsal raphe nucleus studied using fast cyclic voltammetry Fundamental and Clinical Pharmacology, 5, 406P [Details]
O'Connor, J.J. & Kruk, Z.L. (1991) 5-HT1-like and 5-HT1B receptor ligands but not 5-HT1A ligands modulate 5-HT release in the suprachiasmatic nucleus of the rat British Journal of Pharmacology, 104, 64P [Details]
Managhan-Vaughan, D., O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1990) Comparison of the effects of buspirone analogues and 1-(2-pyrimidinyl)-piperazine on synaptic transmission in the rat hippocampus in vivo British Journal of Pharmacology, 99, 29P [Details]
Trout, S.J., O'Connor, J.J., Wieczorek, W. & Kruk, Z.L. (1990) Regional differences in evoked striatal dopamine overflow using fast cyclic voltammetry in brain slices British Journal of Pharmacology, 99, 258P [Details]
O'Connor, J.J., Trout, S.J. & Kruk, Z.L. (1990) Evoked dopamine overflow from rat forebrain nuclei measured using fast cyclic voltammetry in vitro European Journal of Pharmacology, 183(4), 285P [Details]
Gonzalez-Mora, J., Mas, M., O'Connor, J.J., Trout, S.J. & Kruk, Z.L. (1990) Qualitative and quantitative estimation of dopamine and 5-HT in mixtures assessed by fast cyclic voltammetry (FCV) and numeric analysis British Journal of Pharmacology, 100, 399P [Details]
O'Connor, J.J. & Kruk, Z.L. (1990) Effects of 5-HT1 receptor agonists on stimulated endogenous 5-HT overflow studied using fast cyclic voltammetry British Journal of Pharmacology, 102, 133P [Details]
O'Connor, J.J. & Kruk, Z.L. (1990) Measurement of stimulated endogenous 5-hydroxytryptamine release in rat brain slices using fast cyclic voltammetry British Journal of Pharmacology, 100, 552P [Details]
Rowan, M.J., Anwyl, R. & O'Connor, J.J. (1989) Neurophysiological actions of ECT and antidepressants on serotonergic and excitatory synaptic transmission Journal of Psychopharmacology, 1, 54 [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1989) Augmentation of the inhibitory effects of buspirone in the rat hippocampus after longterm treatment Irish Journal of Medical Science, 157, 362 [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1989) Buspirone produces a use-dependant block of synaptic transmission in the rat hippocampus in vivo Irish Journal of Medical Science, 158, 128P [Details]
Rowan, M.J., O'Connor, J.J. & Anwyl, R. (1989) Inhibition of excitatory transmission in the rat hippocampus by antidepressants Journal of Psychopharmacology, 1, 159 [Details]
Rowan, M.J., O'Connor, J.J. & Anwyl, R. (1989) Serotonergic inhibition of auditory evoked responses recorded in the rat hippocampus British Journal of Pharmacology, 95, 662P [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1989) Comparison of the acute and chronic effects of buspirone on synaptic transmission in the rat hippocampus British Journal of Pharmacology, 95, 503P [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1988) Blockade of the inhibitory effect of the anxiolytic buspirone in the rat hippocampus using the novel 5-HT1A receptor antagonist spiroxatrine Irish Journal of Medical Science, 157, 23-24 [Details]
Rowan, M.J., O'Connor, J.J. & Anwyl, R. (1988) 5-HT receptor antagonists prevent the inhibitory effects of systemic and local injection of buspirone in the rat hippocampus British Journal of Pharmacology, 93, 91P [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1988) Chronic imipramine treatment inhibits excitatory synaptic transmission in the rat hippocampus in vivo British Journal of Pharmacology, 93, 148P [Details]
O'Connor, J.J., Rowan, M.J. & Anwyl, R. (1987) The effects of 5-hydroxytryptamine agonists and antagonists on auditory evoked potentials in the rat Irish Journal of Medical Science, 156, 294 [Details]
       

Editorial

O'Connor, WT,O'Connor, JJ,Lowry, JP,O'Neill, RD; (2002) 9th International Conference on In Vivo Methods Monitoring Molecules in Neuroscience, June 16-19, 2001, University College Dublin, Ireland - Foreword. Editorial [DOI] [Details]
                   

Guest Lectures

O' Connor, J.J.; (1995) Metabotropic glutamate receptors and synaptic transmission. Guest Lectures [Details]
O'Connor, J.J. (1990) Measurement of stimulated endogenous 5-hydroxytryptamine release in rat brain slices using fast cyclic voltammetry. Guest Lectures [Details]
O'Connor, J.J.; (1986) Antidepressants, 5-hydroxytryptamine and evoked potentials in the rat. Guest Lectures [Details]
   

Invited Seminars

O'Connor, J.J.; (2011) The immune system and the brain: an important role for pro-inflammatory cytokines in the hippocampus. Invited Seminars [Details]
O'Connor JJ; (2010) Fast cyclic voltammetry and the measurement of single pulse dopamine release. Invited Seminars [Details]
O'Connor, J.J. (2003) Cytokines and Synaptic plasticity. Invited Seminars [Details]
   

Abstract

Corcoran, A.E., Kunze, R., Harney, S.C., Breier, G., Marti, H.H., and O'Connor, J.J. (2013) A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity. Abstract [Details]
Corcoran, AE,O'Connor, JJ (2011) Acute effects of prolyl hydroxylase inhibiton on synaptic transmission and plasticity in the rat hippcampal slice. Abstract [Details]
Watters, O,O'Connor, JJ (2011) TNF-a and glutamate preconditioning attenuates calcium mediated activity in the CA1 region of rat organotypic hippocampal cultures. Abstract [Details]
Batti, L,Taylor, C,O'Connor, JJ (2010) A role for the prolyl hydroxylase inhibitor, dmog, on synaptic transmission and neuroprotection in an ex vivo model of stroke. Abstract [Details]
Watters, O,O'Connor, JJ (2010) Modulatory effects of TNF-a and glutamate pretreatment on calcium homeostasis & glutamate-induced calcium influx in rat organotypic hippocampal cultures. Abstract [Details]
Sheridan, GK,Pickering, M,Halley, P,O'Sullivan, NC,O'Connor, JJ,Murphy, KJ (2010) The chemokine, fractalkine (cx3cl1), modulates synaptic plasticity and is upregulated in the rat hippocampus following a spatial learning task. Abstract [Details]
Sheridan, GK,Pickering, M,O'Connor, JJ,Moynagh, PN,Murphy, KJ (2010) Similar temporal oscillations in hippocampal NF-kappa b following spatial learning in rats and high-frequency stimulation of organotypic slice cultures. Abstract [Details]

Invited Lectures

O'Conor JJ; (2009) Effects of tumour necrosis factor-α on synaptic transmission and synaptic plasticity in the rat hippocampus. Invited Lectures [Details]
O'Connor JJ; (2009) Fast cyclic voltammetry and the measurement of real-time dopmine release in brain tissue. Invited Lectures [Details]
O'Connor JJ; (2007) Know your hippocampus. Invited Lectures [Details]
O'Connor JJ; (2006) Discrimination of neurones and glia using calcium imaging. Invited Lectures [Details]
O'Connor, J.J. (2003) An investigation into the effect of putative NFkb inhibitors on LTP and LTD. IL-1 in the CNS. Invited Lectures [Details]
O'Connor, J.J. (2003) IL-1 and synaptic plasticity in the CNS. Invited Lectures [Details]
O' Connor, J.J. (1995) Revision course in Pharmacology/Physiology for part two of the Fellowship in Anaesthetics. Invited Lectures [Details]
O'Connor, J.J. (1994) On recent research advances on NMDA receptors and patch clamping. Invited Lectures [Details]
O'Connor, J.J. (1991) Pharmacological, Biochemical and Physiological classification of 5-HT receptors in the CNS. Invited Lectures [Details]
O'Connor, J.J. (1990) Classification of 5-hydroxytryptamine receptors in the central nervous system of the rat. Invited Lectures [Details]
O' Connor, J.J.; (1989) Monoamine Systems I: 5-HT receptors in the CNS. Invited Lectures [Details]
     

Reviews

O'Connor, JJ (2013) Targeting tumour necrosis factor-alpha in hypoxia and synaptic signalling. Reviews [Details]
Watters, O,O'Connor, JJ (2011) A role for tumor necrosis factor-alpha in ischemia and ischemic preconditioning. Reviews [Details]
                                         

Published abstracts

Lanigan S & O'Connor JJ. (2015) The effect of hypoxia and the hypoxia mimetic protocatechuic acid ethyl ester (EDHB) on synaptic transmission and plasticity in the rat dentate gyrus. Published abstracts [Details]
Audrey Wall, Gatambwa Mukandala, John J. O'Connor. (2014) Hypoxic pre-conditioning improves the recovery of synaptic transmission in the hippocampus. Published abstracts [Details]
                                     

Research

Research Interests

Synaptic physiology

My research interests lie in the area of synaptic transmission and plasticity in the central nervous system, in vitro and in vivo electrophysiological recordings and skeletal muscle physiology. Particular research interests include field and patch-clamp methodologies and synaptic plasticity including long-term potentiation (LTP) in the hippocampus. This area of research with the 'blind' whole-cell patch clamp technique is concentrated on excitatory amino acid neurotransmission (glutamate) and LTP in the hippocampal slice. This activity dependent enhancement of synaptic transmission in the vertebrate brain is now widely used for the investigation of cellular mechanisms for memory formation.

 

Neuroimmunology

Our research group are particularly interested in neuron to neuron signaling in the brain and how the immune system interacts with this. We are particularly interested in how pro-inflammatory molecules modulate synaptic plasticity (a model for memory formation) before and during hypoxic insults to neurons. To this end we are currently investigating how neurons adapt to acute hypoxic exposure. Current investigations are using genetically modified mice which have a specific protein switched off (PHD2, a key regulator of neuronal responses to hypoxia).

 

Fast Cyclic voltammetry

Previously we have monitored neurotransmitter release using novel voltammetric techniques from various brain regions. Voltammetry offers the chance to monitor the release and reuptake of neurotransmitters such as serotonin and dopamine in "real time" in dorsal raphe (5-HT), suprachiasmatic nucleus (5-HT) and striatum (dopamine). Specifically we have in the past investigated the real time monitoring of neuro-transmitter release (dopamine, noradrenaline and 5-HT) in the brain using the technique of fast cyclic voltammetry in collaboration with NUIM. The group is currently investigating the action of dopamine partial agonists on real time stimulated dopamine release in the rat brain slices containing the striatum and nucleus accumbens.

 

Isolated human myometrium

Dr O' Connor has collaborations with a number of anesthetists in the Coombe Women's Hospital in Dublin. Isolated term human myometrium is regularly obtained and isometric recordings taken from tissue. We are particularly interested in the effects of ergometrine on contractility and its use as a second line uterotonic agent. We are also interested in the actions of specific prostaglandins on frequency and amplitude of contractions.

Research Projects

Sponsor : The Wellcome Trust (WT)
Title : Effects of the highly potent and specific NLRP3 inhibitor MCC950 on synaptic transmission and plasticity in the rat hippocampus
Start Date / End Date : 06-JUN-17 / 28-JUL-17
Sponsor : University College Dublin (UCD)
Title : Protocatechuic acid ethyl ester (EDHB) effects on cell viability and synaptic signalling in rat hippocampal and organotypic slices.
Start Date / End Date : 01-APR-17 / 30-SEP-18
Sponsor : University College Dublin (UCD)
Title : The effects of the hypoxia mimetic on synaptic transmission in rat hippocampus.
Start Date / End Date : 01-APR-17 / 30-SEP-18
Sponsor : The Wellcome Trust (WT)
Title : A putative role for the hypoxia mimetic, EDHB, in synaptic signalling and plasticity in the hippocampus
Start Date / End Date : 30-MAY-16 / 24-JUL-16
Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : The Wellcome Trust (WT)
Title : Biomedical Vacation Scholarship
Start Date / End Date : 02-JUN-15 / 07-AUG-15
Sponsor : University College Dublin (UCD)
Title : Development of an in vivo patch clamp assay to investigate neurotransmission in C. elegans models of ciliary disease
Start Date / End Date : 01-APR-14 / 30-SEP-15
Sponsor : The Wellcome Trust (WT)
Title : An investigation into the role of adrenergic receptors in the oxytocic effect of ergometrine on human myometrium in vitro.
Start Date / End Date : 20-MAY-14 / 31-JUL-14
Sponsor : University College Dublin (UCD)
Title : Effect of novel prolyl hydroxylase inhibitors on synaptic transmission and plasticity in the rat hippocampus/An investigation into the inhibitory effect of ergometrine and prostanoid receptor agonists on spontaneous contractures in isolated human myo
Start Date / End Date : 19-MAY-14 / 01-DEC-15
Sponsor : Science Foundation Ireland (SFI)
Title : A Potential role for hydroxylases in mild hypoxic perturbation of synaptic transmission
Start Date / End Date : 01-OCT-09 / 30-SEP-13
Sponsor : University College Dublin (UCD)
Title : Detecting dopamine in real time with fast cyclic voltammetry
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Coombe Women's Hospital
Title : Is there a modulatory role per met-enkephalis in human myometrial contractulating in labour? (equipment and supplies)
Start Date / End Date : 01-OCT-05 / 31-DEC-08
Sponsor : Internal Transfer
Title : Effect of Cytolrines on Dopamime Neurotransmission using FCV
Start Date / End Date : 01-OCT-03 / 30-SEP-06
Sponsor : Higher Education Authority (HEA)
Title : Determining the mechanisms by which TNF Alpha modulates Synaptic Plasticity - electrophysiology
Start Date / End Date : 01-OCT-02 / 31-OCT-07
Sponsor : Higher Education Authority (HEA)
Title : Determining the mechanisms whereby TnF modulates glutamate-induced currents and long-term potentiation in single granule cells
Start Date / End Date : 01-OCT-02 / 30-SEP-05
Sponsor : Higher Education Authority (HEA)
Title : Identification of a novel pro-inflammatory Signalling Molecule in the Brain
Start Date / End Date : 01-OCT-02 / 31-DEC-07
Sponsor : Health Research Board (HRB)
Title : The role of Jun N-terminal kinase in long-term potentiation in the dentate gyrus of the hippocampus
Start Date / End Date : 01-OCT-99 / 30-SEP-02
Sponsor : Enterprise Ireland (EI)
Title : An investigation into the role of the p42/44 and p38 mitogen activated protein kinase pathways on NMDA-dependent and NMDA-independent long-term potentiation in hippocampal neurones
Start Date / End Date : 01-OCT-98 / 01-OCT-01
Sponsor : The Wellcome Trust (WT)
Title : Role of mitogen activated protein (MAP) kinases in long-term potentiation in hippocampal slices
Start Date / End Date : 15-JUN-98 / 15-AUG-98
Sponsor : Health Research Board (HRB)
Title : Electrophysiological studies into the effects of IL-1beta on glutamate receptors and long-term potentiation in the rat hippocampus
Start Date / End Date : 01-JUL-95 / 30-JUN-96
Sponsor : Enterprise Ireland (EI)
Title : Studies into the role of glutamate receptor subtypes on long-term potentiation in the rat hippocampus
Start Date / End Date : 01-NOV-94 / 31-OCT-96
Sponsor : The Wellcome Trust (WT)
Title : No Project title to migrate.
Start Date / End Date : 01-MAY-94 / 08-MAY-94

Recent Postgraduates

  • Gatambwa Mukandala
  • Audrey Wall
  • Alan Corcoran
  • Laura Batti
  • Orla Watters

 

 

Current Postgraduate Students

Sinead Lanigan, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

Teaching Philosophy

My approach to teaching and learning uses a Blended and Interactive approach where I ask questions in lectures, small and large and in practicals, use a humorous style, combined with serious and balanced content continually engaging the students.

Modules Coordinated

201700   NEUR40020     Neuroscience: Synaptic plasticity
201700   NEUR30060     Neuroscience: Sensory Neuroscience
201700   NEUR40060     Neuroscience: Neuroscience Research Project
       

Collaborators

Internal Collaborators

  • Dr Caroline Herron, SBBS
  • Dr Brendan Kennedy, SBBS
  • Professor Cormac Taylor, School of Medicine
  • Dr. Mark Pickering, School of Medicine
  • Dr Keith Murphy, SBBS
  • Dr Ken O'Halloran, School of Medicine
  • Dr Kathy O'Boyle, SBBS

External Collaborators

  • Professor Nigel Greig, NIH, USA
  • Professor Michael Rabinowitz, J & J, USA
  • Professor Hugo Marti, University of Heidelberg, Germany
  • Professor John Lowry, NUIM, Maynooth
  • Dr Zyg Kruk, Portsmouth, UK
  • Dr Michael Carey, Coombe Hospital Dublin
  • Dr Rebecca Fanning, Coombe Hospital Dublin
  • Professor Luke O'Neill, Trinity College, Dublin