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researcher

Kathy O'Boyle

Senior Lecturer

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166760
Email: koboyle@ucd.ie

Biography

Vice Principal for T&L, UCD College of Science, 2011-2014
Head of Teaching & Learning, SBBS 2007-2011

Head of Subject for Pharmacology, UCD 2005-2007
Senior Lecturer, Department of Pharmacology, UCD 1997-to date
President's Prize for Research, UCD 1999
Judge, Young Scientist Exhibition 1996-to-date
College Lecturer, Department of Pharmacology, UCD 1989-1997
Research Fellow, Royal College of Surgeons in Ireland 1987-1989
Rafaelson Scholar, Colegium Internationale Neuro-Psychoparmacologicum 1988
Honorary Lecturer in Pharmacology, Royal College of Surgeons in Ireland 1985-1989
Research Assistant, Royal College of Surgeons in Ireland 1983-1986

Research Links: SBBS Research  |  Mechanisms of Disease Research in SBBS  

Professional

Honours and Awards

Year: 2001.
Title: UCD Travel Award

Associations

Association: Irish Neurosciences Research Group, Function/Role: 1983
Association: International Brain Research Organisation, Function/Role: 1987
Association: British Pharmacological Society, Function/Role: 1988
Association: Irish Association of Pharmacologists, Function/Role: 1989
Association: Women in Science and Technology, Function/Role: 1992
Association: Irish Research Scientists Association, Function/Role: 1992
Association: Royal Academy of Medicine in Ireland. Appointed to Council 1995., Function/Role: 1993
Association: Society for Neuroscience, USA, Function/Role: 1995
     

Conference Contributions

OBrien, A., Dunne, A., Enright, P.M., Pitt, N., Mulcahy, C., OBoyle K.M. and Murphy, P.V.; The synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to fibroblast growth factor (FGF). [Published Abstract], 11th European carbohydrate symposium, Abs. PC010.(2001), * .
Fanning, P., OBoyle, K.M.; G-protein activation by 5-HT in rat and bovine striatum. [Published Abstract], 4th IUPHAR Satellite Meeting on Serotonin, * .
Murphy, P.V., Enright, P.M., Bradley, H., OBrien, J.L., OBrien, A., Dunne, A. and OBoyle, K.M. (2001) ,; Toward the synthesis and evaluation of novel monovalent and multivalent glycoconjugate libraries,. [Published Abstract], 11th European carbohydrate symposium (2001), * .
Nolan, B. Briody, C. and OBoyle K.M.; (2004) Effects of caffeine on D1 dopamine receptors in rat striatum. [International Refereed Conference], British Pharmacological Society, Bath, UK , 06-JUN-04 - 09-JUL-04.
Hogan, N.M., OBoyle, K.M. and Kelly, J.A.; (2004) Behavioural evaluation of novel TRH-degrading ectoenzyme inhibitors. . [Non Refereed Paper/Abstract Presented at Conference], 34th Society for Neuroscience Meeting, San Diego, USA , 23-OCT-04 - 28-OCT-04.
Duane, R.M., Lynch, C., Pitt, N., Bradley, H., O' Brien, A., Murphy, P.V. and O' Boyle, K.M. ; (2004) The biological evaluation of a novel glycosaminoglycan. . [Non Refereed Paper/Abstract Presented at Conference], US/Japan Glyco 2004, Joint meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research, Hawaii, USA , 24-NOV-04 - 27-NOV-04.
Duane, R.M., Lynch, C., Pitt, N., Bradley, H., O' Brien, A., Murphy, P.V. and O' Boyle, K.M.; (2004) The biological evaluation of disaccharides derived from heparin. . [Non Refereed Paper/Abstract Presented at Conference], US/Japan Glyco 2004, Joint meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research, Hawaii, USA , 24-NOV-04 - 27-NOV-04.

Committees

Committee : Repeats/Resits/Condonation Policy Steering Group
Committee : Science District T&L Group
Committee : College of Life Science T&L Committee
Committee : Engagement and Retention Working Group
Committee : SBBS T&L Working Group
Committee : Task Force on Repeats, Resits and the Academic Calendar
Committee : Science Programme Planning Oversight group
Committee : Science Programme Planning Working Group

Employment

Employer: University College Dublin
Position: Assistant Lecturer
Employer: Royal College of Surgeons in Ireland
Position: Research Assistant
Employer: Royal College of Surgeons in Ireland
Position: Honorary Lecturer
Employer: Royal College of Surgeons in Ireland
Position: Research Fellow
Employer: University College Dublin
Position: College Lecturer
Employer: University College Dublin
Position: Senior Lecturer

Education

Year 1978 Institution: University College Dublin
Qualification: BSc Subject:
Year 1982 Institution: University College
Qualification: PhD Subject: Pharmacology
Year 1983 Institution: University College Dublin
Qualification: PhD Subject:
   

Outreach Activities

Judge, Young Scientists& Technology Exhibition
   

Publications

 

Book Chapters

Monaghan M, Carthy J, O'Boyle KM, Sokell E, Wilson W and Naidoo G; (2011) 'Designing buildings for student-centred learning: the science centre at University College Dublin' In: Suchman AL, Sluyter DJ and Williamson P (eds). Leading change in healthcare. London: Radcliff Publishing Ltd. , pp.211-235 [Details]
OBoyle, K.M.; (1997) 'Central Neurotransmitters' In: (eds. S. O'Meara & M. Lynch), BIOS Scientific Publishers Ltd., Oxford (eds). Neurobiology Labfax. , pp.107-120 [Details]
Waddington, J.L., Daly, S.A., McCauley, P.G. & OBoyle, K.M.; (1993) 'Levels of functional interaction between 'D-1-like' and 'D-2-like' dopamine receptor systems' In: (ed. H.B. Niznik), Marcel Dekker, New York (eds). Dopamine Receptors. , pp.513-538 [Details]
Waddington, J.L., Molloy, A.G. & OBoyle, K.M.; (1988) 'Behavioural effects of long-term treatment with further typical neuroleptics and selective D2 dopamine receptor antagonists in young and aged animals' In: (M. Sandler, A. Dahlstrom & R. Belmaker, Eds.) Alan R. Liss, New York, (eds). Progress in Catecholamine Research Part B: Central Aspects. , pp.43-46 [Details]
Waddington, J.L., Molloy, A.G., OBoyle, K.M. & Mashurano, M.; (1986) 'Enantiomeric analogues of SCH 23390 as new probes for behavioural interactions between D-1 and D-2 dopaminergic function' In: (G.R. Breese & I. Creese, Eds.), Plenum Press, New York (eds). The Neurobiology of Central D-1 Receptors. , pp.125-136 [Details]
OBoyle, K.M., Molloy, A.G. & Waddington, J.L.; (1986) 'Benzazepine derivatives: nature of the selective and stereospecific interactions of SK&F 38393 and SCH 23390 with brain D-1 receptors' In: (G.N. Woodruff, J.A. Poat & P.J. Roberts, Eds.), MacMillan Press, London (eds). Dopamine Systems and their Regulation. , pp.385-386 [Details]
 

Peer Reviewed Journals

Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O (2014) 'First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models'. Neuropharmacology, 89C :193-203. [DOI] [Details]
Downey, C., Daly, F., O'Boyle, KM (2013) 'An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine'. Toxicology in Vitro, . Available Online [DOI] [Details]
Naughton C, Drennan J, Hyde A, Allen D, O'Boyle K, Felle P, Butler M. (2013) 'An evaluation of the appropriateness and safety of nurse and midwife prescribing in Ireland'. Journal of Advanced Nursing, 69 (7):1478-1488. [DOI] [Details]
Zhao Y, Zhou Y, O' Boyle KM, Murphy PV.; (2010) 'Biological study of the angiogenesis inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin'. Chemical Biology and Drug Design, 75 (6):570-577. [Details]
O'Neill C., Evers Donnelly, A., O'Boyle K.M. and O'Connor J.J. ; (2009) 'D2 receptor mediated inhibition of dopamine release from rat striatum is modulated by CB1 receptors: studies using fast cyclic voltammetry'. Journal of Neurochemistry, 108 (3):545-551. [Details]
Drennan, J,Naughton, C,Allen, D,Hyde, A,O'Boyle, K,Felle, P,Treacy, M,Butler, M; (2011) 'Patients' level of satisfaction and self-reports of intention to comply following consultation with nurses and midwives with prescriptive authority: A cross-sectional survey'. International Journal of Nursing Studies, 48 :808-817. [DOI] [Details]
Zhao, YX,Zhou, Y,O'Boyle, KM,Murphy, PV; (2008) 'Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis'. Bioorganic and Medicinal Chemistry, 16 (NA):6333-6337. [DOI] [Details]
Hogan, N,O'Boyle, KM,Hinkle, PM,Kelly, JA; (2008) 'A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH(2), binds to [H-3][3-Me-His(2)]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2'. Neuroscience Letters, 431 :26-30. [DOI] [Details]
Zhou, Y,Zhao, Y,O'Boyle, KM,Murphy, PV; (2008) 'Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles'. Bioorganic and Medicinal Chemistry, 18 :954-958. [DOI] [Details]
Zaric V, Doyle D, Murphy PV, O'Boyle KM. ; (2007) 'Inhibition of endothelial cell proliferation by per-O-acetylated mannose conjugates'. Anticancer Research, 27 :1331-1335. [Details]
Scalabrino, GA,Hogan, N,O'Boyle, KM,Slator, GR,Gregg, DJ,Fitchett, CM,Draper, SM,Bennett, GW,Hinkle, PM,Bauer, K,Williams, CH,Tipton, KF,Kelly, JA; (2007) 'Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone'. Neuropharmacology, 52 :1472-1481. [DOI] [Details]
O'Connor JJ, O'Neill C, Nolan BJ, Macari A, O'Boyle KM, ; (2007) 'Adenosine A1 receptor-mediated inhibition of dopamine release from rat striatal slices is modulated by D1 dopamine receptors'. European Journal of Neuroscience, 26 (12):3421-3428. [DOI] [Details]
Rawe, SL; Zaric, V; O'Boyle, KM; Murphy, PV; ; (2006) 'N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - A significant increase in potency using per-O-acetylated sugar analogues'. Bioorganic and Medicinal Chemistry Letters, 16 (5):1316-1319. [Details]
Rawe, SL; Doyle, D; Zaric, V; Rozas, I; McMahon, K; Tosin, M; Bunz, HM; Murphy, EP; O'Boyle, KM; Murphy, PV; ; (2006) 'N-glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'. Carbohydrate Research, 341 (10):1370-1390. [Details]
Rawe, SL; Doyle, D; Zaric, V; Rozas, I; McMahon, K; Tosin, M; Bunz, HM; Murphy, EP; O'Boyle, KM; Murphy, PV; ; (2006) 'N-glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'. Carbohydrate Research, 341 (10):1370-1390. [Details]
Duane, RM; O'Brien, A; Lynch, C; Murphy, PV; O'Boyle, KM; ; (2004) 'The biological evaluation of disaccharides derived from heparin'. Glycobiology, 14 (11):1103-1104. [Details]
Pitt, N,Duane, RM,O' Brien, A,Bradley, H,Wilson, SJ,O'Boyle, KM,Murphy, PV; (2004) 'Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects-on endothelial cell growth'. Carbohydrate Research, 339 :1873-1887. [DOI] [Details]
O'Brien, A,Lynch, C,O'Boyle, KM,Murphy, PV; (2004) 'Synthesis of disaccharides derived from heparin and evaluation of effects on endothelial cell growth and on binding of heparin to FGF-2'. Carbohydrate Research, 339 :2343-2354. [DOI] [Details]
O'Brien, A; Pitt, N; Duane, R; Wilson, S; Dunne, A; O'Boyle, KM; Murphy, PV; ; (2002) 'Synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to FGF'. Abstracts of Papers of the American Chemical Society, 224 (NA):39-39. [Details]
Kelly, JA,Slator, GR,O'Boyle, KM; (2002) 'Pharmacologically distinct binding sites in rat brain for [H-3]thyrotropin-releasing hormone (TRH)and [H-3][3-methyl-histidine(2)] TRH'. Biochemical Pharmacology, 63 :2197-2206. [DOI] [Details]
Murphy, PV,Pitt, N,O'Brien, A,Enright, PM,Dunne, A,Wilson, SJ,Duane, RM,O'Boyle, KM; (2002) 'Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library'. Bioorganic and Medicinal Chemistry, 12 :3287-3290. [DOI] [Details]
Murphy, PV; Pitt, N; O'Brien, A; Enright, PM; Dunne, A; Wilson, SJ; Duane, RM; O'Boyle, KM; ; (2002) 'Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library'. Bioorganic and Medicinal Chemistry Letters, 12 (22):3287-3290. [Details]
O'Loinsigh, ED; Boland, G; Kelly, JP; O'Boyle, KM; ; (2001) 'Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat'. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 25 (3):621-638. [Details]
Enright, PM; O'Boyle, KM; Murphy, PV; ; (2000) 'Synthesis of D-hexos-5-uloses by novel in situ hydrolysis of epoxides derived from 6-deoxyhex-5-enopyranosides'. Organic Letters, 2 (24):3929-3932. [Details]
Doyle E, O'Boyle KM, Regan CR and Shiotani T; (1996) 'Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance responseh a non-dopaminergic mechanism'. Neurochemical Research, 21 :649-652. [Details]
OBoyle, K.M. & Lawlor, M.; (1996) 'D2 receptor agonists and partial agonists: relationship between receptor binding measures and functional activity'. Biochemical Society Transactions, 24 :183-188. [Details]
Waddington JL, Daly SA, Downes RP, Devaney AM, McCawley PG and O'Boyle; (1995) 'Behavioural pharmacology of D-1-like dopamine receptors: further subtyping, new pharmacological probes and interactions with D-2-like receptors'. Progress in Neuro-Psychopharmacology & Biological Psych, 19 :811-831. [Details]
O'Malley, K.E., Farrell, C.B., OBoyle, K.M. & Baird, A.W.; (1995) 'Cholinergic activation of chloride secretion in rat colonic epithelia'. European Journal of Pharmacology, 275 :83-89. [Details]
McCawley, P.G., OBoyle, K.M. & Waddington, J.L.; (1995) 'Dopamine-induced reduction in guanine nucleotide-sensitive D1 receptor density in human postmortem brain in the absence of apparent D1:D2 interactions'. Neuropharmacology, 34 :777-783. [Details]
Farrell, C.B., Lawlor, M., Dunne, A. & OBoyle, K.M.; (1995) 'D2 receptor antagonists do not modify guanine nucleotide-sensitive interactions between dopamine and D1 dopamine receptors under in vitro conditions'. Neurochemistry, 65 :1124-1130. [Details]
Farrell, C.B. & OBoyle, K.M. ; (1994) 'The kinetics of [3H]SCH 23390 dissociation from rat striatal dopamine D1 receptors: effect of dopamine'. European Journal of Pharmacology, 268 :79-88. [Details]
OBoyle, K.M., Gavin, K.T. & Harrison, N.; (1993) 'Chronic antagonist treatment does not alter the mode of interaction of dopamine with rat striatal dopamine receptors'. Journal of Receptor Results, 13 (1-4):329-339. [Details]
OBoyle, K.M. & Waddington, J.L.; (1992) 'Agonist and antagonist interactions with D-1 dopamine receptors: agonist-induced masking of D-1 receptors depends on intrinsic activity'. Neuropharmacology, 32 :177-183. [Details]
Waddington, J.L. and OBoyle, K.M.; (1989) 'Drugs acting on brain dopamine receptors: a conceptual re-evaluation five years after the first selective D-1 antagonist'. Pharmaceutical Therapy, 43 :1-52. [Details]
OBoyle, K.M., Gaitanopoulos, D.E., Brenner, M. & Waddington, J.L.; (1989) 'Agonist and antagonist properties of benzazepine and thienopyridine derivatives at the D-1 dopamine receptor'. Neuropharmacology, 28 :401-405. [Details]
OBoyle, K.M. & Waddington, J.L.; (1987) '3H-SCH 23390 binding to D-1 dopamine receptors in human brain'. Biogenic Amines, 4 :365-370. [Details]
OBoyle, K.M. & Waddington, J.L.; (1987) 'New substituted 1-phenyl-3-benzazepine analogues of SK&F 38393 and N-methyl-thienopyridine analogues of dihydroxynomifensine with selective affinity for the D-1 dopamine receptor in human post-mortem brain'. Neuropharmacology, 26 :1807-1810. [Details]
OBoyle, K.M. & Waddington, J.L.; (1987) '3H-SCH 23390 binding to human putamen D-1 dopamine receptors: stereochemical and structure-affinity relationships among 1-phenyl-1H-3- benzazepine derivatives as a guide to D-1 receptor topography'. Neurochemistry, 48 :1039-1042. [Details]
Waddington, J.L. & OBoyle, K.M.; (1987) 'The D-1 dopamine receptor and the search for its functional role: from neurochemistry to behaviour'. Review of Neuroscience, 1 :157-184. [Details]
Waddington JL, Molloy AG and O'Boyle KM; (1986) 'Motor consequences of D1 dopamine receptor stimulation and blockade'. Clinical Neuropharmacology, 9 :20-22. [Details]
OBoyle, K.M. & Waddington, J.L.; (1986) 'A re-evaluation of changes in rat striatal D2 dopamine receptors during development and aging'. Neurobiology of Aging, 7 :265-267. [Details]
Molloy, A.G., OBoyle, K.M., Pugh, M.T. and Waddington, J.L.; (1986) 'Locomotor behaviours in response to new selective D1 and D2 dopamine receptor agonists, and the influence of selective antagonists'. Pharmacology, Biochemistry and Behaviour, 25 :249-253. [Details]
OBoyle, K.M., Molloy, A.G., Mashurano, M. & Waddington, J.L.; (1986) 'Structural analogues of SCH 23390 as discriminators of dopamine receptor sub-types: behavioural interactions between D-1 and D-2 agonists and antagonists'. Psychopharmacology Bulletin, 22 :599-604. [Details]
Waddington, J.L., Youssef, H.A., Molloy, A.G., OBoyle, K.M. & Pugh, M.T.; (1985) 'Association of intellectual impairment, negative symptoms, and aging with tardive dyskinesia: clinical and animal studies'. Journal of Clinical Psychology, 46 :29-33. [Details]
Waddington, J.L., Molloy, A.G., OBoyle, K.M. & Youssef, H.A.; (1985) 'Spontaneous and drug-induced dyskinesias in rodents in relation to ageing and long-term neuroleptic treatment: relationship to tardive dyskinesia'. Biological Psychiatry, :1151-1153. [Details]
Pugh, M.T., OBoyle, K.M., Molloy, A.G. & Waddington, J.L.; (1985) 'Effects of the putative D1 antagonist SCH 23390 on stereotyped behaviour induced by the D2 agonist RU 24213'. Psychopharmacology, 87 :308-312. [Details]
OBoyle, K.M. & Waddington, J.L.; (1985) 'Structural determinants of selective affinity for brain D-1 dopamine receptors within a series of 1-phenyl-1H-3-benzazepine analogues of SK&F 38393 and SCH 23390'. European Journal of Pharmacology, 115 :291-295. [Details]
Callanan KM and Keenan AK; (1984) 'Differential effects of D600, nifedipine and dantrolene-sodium on excitation-secretion coupling and presynaptic B-aderenaceptor responses in rat atria'. British Journal of Pharmacology, 83 :841-847. [Details]
OBoyle, K.M. & Waddington, J.L.; (1984) 'Selective and stereospecific interactions of R-SK&F 38393 with 3H-piflutixol but not 3H-spiperone binding to striatal D-1 and D-2 dopamine receptors: comparisons with SCH 23390'. European Journal of Pharmacology, 98 :433-436. [Details]
OBoyle, K.M. & Waddington, J.L.; (1984) 'Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites: association with increased non-specific binding of the D-1 ligand 3H-piflutixol'. European Journal of Pharmacology, 105 :171-174. [Details]
OBoyle, K.M. & Waddington, J.L.; (1984) 'Identification of the enantiomers of SK&F 83566 as specific and stereoselective antagonists of the striatal dopamine receptors: comparisons with the D-2 enantioselectivity of Ro22-1319'. European Journal of Pharmacology, 106 :219-220. [Details]

Other Journals

Nolan B and O'Boyle KM; (2006) 'Effects of adenosine receptor ligands on D1 dopamine receptors in rat striatum' Irish Journal of Medical Science 175 (1) . [Details]
O'Neill, C., Nolan, B., O'Boyle, K., O'Connor, J.J.; (2006) 'SCH23390 attenuates A1 receptor-mediated inhibition of electrically evoked dopamine release from rat striatal slices' British Journal of Pharmacology 3 (4) . [Details]
Evers-Donnelly, A., O'Neill, C., O'Boyle, K., O'Connor, J.J.; (2006) 'Modulation of dopamine release by cannabinoid receptor activation in rat striatal slices' Irish Journal of Medical Science 175 (3) . [Details]

Conference Publications

O'Neill, G., Doyle, E., O'Boyle, K., Clipson, N.; (2010) Choice of Assessment Methods within a Module: Students Experiences and Staff Recommendations for Practice AISHE-C 2010: Dublin, Available Online [Details]
Ciaran Downey, Francesca Daly, Alan Kirwan, Kathy O¿Boyle; (2009) Effects of MDMA and caffeine on serotonin uptake by rat whole brain synaptosomes British Pharmacological Society, Summer Meeting, 8-10 July, Edinburgh Available Online [Details]
Brian Nolan, Kathy O¿Boyle; (2009) Interaction between 6-chloro PB and CCPA on [35S]GTPγS binding in rat striatum British Pharmacological Society, Summer Meeting, 8-10 July, Edinburgh Available Online [Details]
O'Boyle KM; (2009) Interaction between caffeine and MDMA British Pharmacological Society, Edinburgh, July 2009 [Details]
O'Boyle KM; (2008) Enhancing assessment practice in the UCD School of Biomolecular and Biomedical Sciences International Colloquium on University Teaching and Learning: Exploring the Dialogue of Community Practice [Details]
Downey C and O'Boyle KM; (2008) MDMA-induced cytotoxicity and interactions with CYP3A4 or CYP1A2 drug metabolising enxymes is not altered by acffeine Neuroscience 2008 Washington DC, , 14-NOV-08 - 19-NOV-08 [Details]
Downey C, O¿Boyle K.M.; (2007) Effects of MDMA and caffeine on renal cells and drug metabolising enzymes \i British Pharmacological Society0 Available Online [Details]
Nolan, B., O¿Boyle K.M. ; (2007) The effects of caffeine on adenosine and dopamine receptor density in rat striatum \i British Pharmacological Society00 Available Online [Details]
O'Neill C., Nolan B., O'Boyle K.M. and O'Connor J.J. ; (2006) SCH23390 attenuates A1 receptor-mediated inhibition of electrically evoked dopamine release from rat striatal slices British Journal of Pharmacology. Vol 3, Issue 4, 067P [Details]
Evers-Donnelly, A., O'Neill, C., O'Boyle, K., O'Connor, J.J. ; (2006) Modulation of dopamine release by cannabinoid receptor activation in rat striatal slices Irish journal of Medical Science, Volume 175(3) (electronic supplement 1), p41 [Details]
Duane, RM; Lynch, C; Pitt, N; Bradley, H; O'Brien, A; Murphy, PV; O'Boyle, KM; ; (2004) GLYCOBIOLOGY The biological evaluation of a novel glycosaminoglycan , pp.1099-1100 [Details]
Nolan B, Briody C, O'Boyle KM; (2004) Effects of caffeine on D1 dopamine receptors in rat striatum British PharmacologicalSociety Available Online [Details]
O'Brien, A; Pitt, N; Duane, R; Wilson, S; Dunne, A; O'Boyle, KM; Murphy, PV; ; (2002) ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to FGF , pp.39-39 [Details]
Kelly, JA; Bennett, GW; Beckett, S; Slator, GR; Roe, CH; O'Loinsigh, ED; O'Boyle, KM; ; (2001) BRITISH JOURNAL OF PHARMACOLOGY Effects of thyrotropin-releasing hormone-degrading ectoenzyme inhibitors on thyrotropin-releasing hormone actions in vivo , pp.97-97 [Details]
O'Loinsigh E, Kelly J, O'Boyle KM; (2001) Evidence for a critical role of body temperature in the modulation of MDMA neurotoxicity by drugs of abuse British Pharmacological Society [Details]
Kelly JA, Bennett GW, Beckett S et al; (2001) Effects of thyrotropin-releasing hormone-degrading ectoenzyme inhibitors on thyrotropin-releasing hormone actions in vivo British Pharmacological Society [Details]
O'Loinsigh, E; Kelly, JP; O'Boyle, KM; ; (2001) BRITISH JOURNAL OF PHARMACOLOGY Evidence for a critical role of body temperature in the modulation of MDMA by drugs of abuse [Details]
O'Loinsigh, ED; Kelly, JP; O'Boyle, KM; ; (2000) BRITISH JOURNAL OF PHARMACOLOGY Co-administration of D-amphetamine alters the acute and long-term effects of 3,4-methylene-dioxymethamphetamine in rats , pp.6-7 [Details]
Page, DT; O'Conner, N; Rogers, M; Martin, F; O'Boyle, KM; ; (1999) BRITISH JOURNAL OF PHARMACOLOGY Evidence for interactions between D-1 and D-2s dopamine receptors co-expressed in BHK cells , pp.14-14 [Details]
O'Connor, N; Page, D; Martin, F; Rogers, M; O'Boyle, KM; ; (1998) BRITISH JOURNAL OF PHARMACOLOGY Actions of dopamine and A68930 on BHK cells co-transfected with D-1 and D-2 receptors , pp.42-42 [Details]
O'Connor, N; O'Boyle, KM; ; (1998) BRITISH JOURNAL OF PHARMACOLOGY G-protein activation through D-1 receptors in a hamster kidney cell line , pp.36-36 [Details]
Hurley, P; McMahon, R; Fanning, P; O'Boyle, KM; Voigt, M; Rogers, M; Martin, F; ; (1997) BRITISH JOURNAL OF PHARMACOLOGY Direct evidence that ligand activation of the human 5-HT5A receptor results in coupling to G-proteins in HEK-293 cells [Details]
O'Boyle KM and Waddington JL; (1988) Inhibition of dopamine stimulated adenylate cyclase by benzazepine derivatives Inhibition of dopamine stimulated adenylate cyclase by benzazepine derivatives , pp.33-34 [Details]
Waddington JL, Molloy AG and O'Boyle KM; (1986) Characterisation of orofacial movements during long-term neuroleptic treatment in relation to ageing and changes in dopamine receptors Characterisation of orofacial movements during long-term neuroleptic treatment in relation to ageing and changes in dopamine receptors [Details]
O'Boyle KM and Waddington JL; (1986) Human brain D-1 dopamine receptors labelled with 3H-SCH 23390 Human brain D-1 dopamine receptors labelled with 3H-SCH 23390 [Details]
Waddington JL and O'Boyle KM; (1985) Human brain D-1 dopamine receptors labelled with 3H-SCH 23390 Human brain D-1 dopamine receptors labelled with 3H-SCH 23390 [Details]
Waddington JL, Molloy AG and O'Boyle KM; (1985) Contribution of ageing processes to the emergence of orofacial movements during long-term neuroleptic treatment Contribution of ageing processes to the emergence of orofacial movements during long-term neuroleptic treatment , pp.108-109 [Details]
O'Boyle KM, Molloy AG and Waddington JL; (1985) Properties of a new stereoselective antagonist at brain D-1 dopamine receptors Properties of a new stereoselective antagonist at brain D-1 dopamine receptors , pp.153-154 [Details]
Pugh MT, O'Boyle KM and Waddington JL; (1985) Functional interactions between brain D-1 and D-2 dopamine receptors revealed using new selective agonist and antagonist drugs Functional interactions between brain D-1 and D-2 dopamine receptors revealed using new selective agonist and antagonist drugs [Details]
Molloy AG, O'Boyle KM and Waddington JL; (1985) The brain D-1 dopamine receptor and ageing The brain D-1 dopamine receptor and ageing [Details]
Waddington JL, Youssef HA, O'Boyle KM and Molloy AG; (1984) Involuntary orofacial movements in relation to neuroleptic treatment, intellectual impairment and aging in schizophrenic patients and senescent animals Involuntary orofacial movements in relation to neuroleptic treatment, intellectual impairment and aging in schizophrenic patients and senescent animals [Details]
Waddington JL, O'Boyle KM and molloy AG; (1983) The stereospecific behavioural effects of the entantiomers of SK&F 38393 and their interactions with dopaminergic binding sites fro 3H-piflutixol and 3H-spiperone The stereospecific behavioural effects of the entantiomers of SK&F 38393 and their interactions with dopaminergic binding sites fro 3H-piflutixol and 3H-spiperone [Details]

Published Reports

Dr. Jonathan Drennan Dr Corina Naughton Ms Deirdre Allen Dr. Abbey Hyde Dr. Pat Felle Dr. Kathy O'Boyle Professor Pearl Treacy Dr. Michelle Butler; (2009) National Independent Evaluation of the Nurse/Midwife Prescribing Initiative. Dublin, Dublin. [Details]
Drennan J, naughton C, Hyde A, Brennan D, Felle P, O'Boyle K, Treacy P, Butler M; (2009) National Independent Evaluation of the Nurse/Midwife Prescribing Initiative. Health Service Executive, Dublin. Available Online [Details]
Drennan J, Naughton C, Allen D, Hyde A, Felle P, O'Boyle K, Treacy P, Butler M; (2009) National Independent Evaluation of the Nurse and Midwife Prescribing Initiative. University College Dublin, Dublin. [Details]
Drennan J, Naughton C, Allen D, Hyde A, Felle P, O'Boyle K, Treacy MP, Butler P; (2009) National Independent Evaluation of Nurse and Midwife Prescribing Initiative. Health Service Executive, Dublin. [Details]
Drennan J, Naughton C, Allen D, Hyde A, Felle P, O'Boyle K, Treacy P, Butler M; (2009) National Independent Evaluation of the Nurse and Midwife Prescribing Initiative. University College Dublin, Dublin. [Details]
Drennan J, Naughton C, Allen D, Hyde A, Felle P, O'Boyle K, Treacy P, Butler M; (2009) National Independent Evaluation of the Nurse and Midwife Prescribing Initiative. University College Dublin, Dublin. [Details]
           

Reports

Drennan J., Naughton C., Allen D., Hyde A., Felle P., O'Boyle K., Treacy P., Butler M.; (2009) National Independent Evaluation of the Nurse and Midwife Prescribing Initiative. Dublin: Reports [Details]
                                                                         

Research

Research Interests

Our research group has a broad interest in the mechanisms by which small, biologically active molecules modify activity of their cellular targets. We have two main research priorities: the first is the investigation of G-protein coupled receptors (GPCRs) and their neurotransmitters in the central nervous system (CNS); the second focuses on the development of cell biological techniques for the investigation of novel glycoconjugate modulators of angiogenesis.

Dopamine, serotonin and TRH receptor pharmacology in mammalian brain. Glycoconjugates and angiogenesis. Drugs of abuse

2nd messenger systems. G-protein activation.

Drug/receptor and receptor/receptor interactions.

Biological testing of novel heparin-like glycomimetics.

Neurotoxicity of ring-substituted amphetamine derivatives

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Neuroscience Ireland 2010
Start Date / End Date : 01-SEP-10 / 31-DEC-10
Sponsor : Internal Transfer
Title : Biological evaluation of heparca- like compounds
Start Date / End Date : 01-JUN-03 / 31-MAY-04
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Ms. Rhona Duane
Start Date / End Date : 01-OCT-02 / 30-SEP-04
Sponsor : Higher Education Authority (HEA)
Title : Long term effects of caffeine on Synaptic Plasticity and Implicit Memory
Start Date / End Date : 01-OCT-02 / 30-SEP-05
Sponsor : Enterprise Ireland (EI)
Title : Systematic study of structure-activity relationships for thyrotropin-releasing hormone (TRH) receptor ligands.
Start Date / End Date : 01-OCT-02 / 30-SEP-05
Sponsor : BioResearch Ireland (BRI)
Title : The synthesis and evaluation of novel iduronic acid conjugates as potential agonists and antagonists of FGF
Start Date / End Date : 01-OCT-00 / 30-SEP-02
Sponsor : Enterprise Ireland (EI)
Title : The medicinal chemistry of novel glycoconjugates; their synthesis and biological evaluation
Start Date / End Date : 01-OCT-00 / 30-SEP-03
Sponsor : Higher Education Authority (HEA)
Title : Conway Research Fellowship
Start Date / End Date : 06-MAR-00 / 05-MAR-02
Sponsor : Enterprise Ireland (EI)
Title : Biological activity of GAG compounds
Start Date / End Date : 01-OCT-99 / 30-SEP-01
Sponsor : Enterprise Ireland (EI)
Title : Neurotoxicity of ecstasy-like drugs
Start Date / End Date : 01-DEC-96 / 30-NOV-98
Sponsor : Enterprise Ireland (EI)
Title : Cell lines which express multiple receptors of commercial interest
Start Date / End Date : 01-FEB-96 / 31-JAN-98
Sponsor : Health Research Board (HRB)
Title : Dopamine and serotonin interactions with G proteins in mammalian brain
Start Date / End Date : 01-JUL-94 / 30-JUN-95
Sponsor : Health Research Board (HRB)
Title : Caffeine and MDMA: A lethal combination
Start Date / End Date : 01-OCT-06 / 30-SEP-09

Recent Postgraduates

Dr. Colm B. Farrell, 'Agonist and antagonist interactions with dopamine D1 recepotrs in rat brain', PhD awarded 1994

Dr. Mark T. Lawlor, ¿Investigations of agonist activity at dopamine D2 receptors and associated G proteins in bovine brain¿, PhD awarded 1996

Dr. Noreen A. O¿Connor, ¿D1:D2 interactions in cell culture systems¿, PhD awarded 1998

Dr. Philip Fanning ¿Dopamine-serotonin interactions with G-proteins in mammalian brain¿, PhD awarded 1999

Dr. Eamon O¿Loinsigh, ¿The acute and long-term effects of MDMA (Ecstacy) in the rat¿, PhD awarded 2001

Dr. Rhona M. Duane, ¿The biological evaluation of novel glycoconjugates¿, PhD awarded 2005

Dr. Nicola Hogan, ¿The pharmacological evaluation of novel TRH analogues¿, PhD awarded 2007

Dr. Brian Nolan, ¿Adenosine and dopamine interactions in the rat brain: effects of ageing and caffeine¿, PhD awarded 2011

Mr Ciaran Downey, 'MDMA and Caffeine: a lethal combination', in progress


 

Collaborators

Internal Collaborators

Dr John O'Connor
Dr Keith Murphy
Prof Sean Callanan
Prof Paul Murphy

External Collaborators

Dr J Kelly, School of Biochemistry and Immunology, TCD