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Keith Murphy

Associate Professor

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166778
Email: keith.murphy@ucd.ie

Biography

Head of SBBS, 2013-2016.
Associate Professor of Pharmacology, 2016-present.
Co-Director, UCD Centre for Applied Neuroscience, 2015-present.
Appointed Theme Leader for Neuroscience Research, Conway Institute, 2011.
Head of Pharmacology, 2007-2011.
Appointed Theme Leader for Neuroscience Research, SBBS, 2007.
Senior lecturer, UCD School of Biomolecular and Biomedical Science, 2006-2016.
Appointed Conway Institute Career Track Investigator, Nov 2002.
Lecturer in Pharmacology, University College Dublin, 2002-2006.
Awarded personal Post-Doctoral Fellowship, HRB grant on identifying the cortical sites of memory storage, 2000-2002. Post-Doctoral Fellowship, EU 5th Framework Program on the role of CAMs in ageing, 1999-2000.
Post-Doctoral Fellowship, Enterprise Ireland basic research grant on mechanisms of addiction, 1997-1999.
Awarded Ph.D. (1997) on 'NCAM-mediated neuroplasticity as a basis for an index theory of memory consolidation' supervisor Prof Ciaran Regan, Department of Pharmacology, UCD.
Awarded Joint B.Sc. 1st class honours in Pharmacology and Mathematics (1994), UCD. Other subjects: Psychology, Chemistry, Biology and Physics.


Research Links: SBBS Research  |  Mechanisms of Disease Research in SBBS 

Professional

Honours and Awards

Year: 2006.
Title: Awarded Rafaelsen Scholarship, CINP Young Investigator award, Collegium Internationale Neuro-psychopharmacologicum, XXVth Congress, Chicago

Associations

Association: British Pharmacological Society, Function/Role: Member
Association: Collegium Internationale Neuro-psychopharmacologicum, Function/Role: Member
Association: Society for Neuroscience, Function/Role: Member
Association: The Federation of European Neuroscience Societies, Function/Role: Member
Association: British Neuroscience Association., Function/Role: Member
     

Conference Contributions

Watters O, Sheridan GK, Murphy KJ, O¿Connor JJ, & Pickering M. ; (2007) TNFα modulates glutamate excitotoxicity and ischemic pre-conditioning depending on the time and order of TNFα and glutamate exposure. [Poster Presentation], Irish Neurosciences Discussion Group, Tullamore , 23-NOV-07 - 24-NOV-07.
Sheridan G., Pickering M., Moynagh P.N., O¿Connor J.J. and Murphy K.J. ; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations. [Oral Presentation], Royal Academy of Medicine in Ireland, Biomedical Sciences Section, UCD , 12-JAN-06 - 12-JAN-06.
Thomas CM, Murphy K J and Regan CM.; (2005) Synaptic modifications underlying memory formation. [Oral Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
O'Boyle K.M., Murphy K., Callanan J.J. ; (2005) MDMA and caffeine: a lethal combination. [Invited Oral Presentation], Proceedings of British Pharmacology Society, London , 14-DEC-05 - 14-DEC-05.
Thomas CW, Murphy KJ, Regan CM.; (2004) Minimal changes to housing environment significantly affect behavior, memory consolidation, and hippocampal neuroanatomy in the male Wistar rat. [Poster Presentation], Society for Neuroscience (SFN), 34th Annual Meeting, San Diego , 23-OCT-04 - 27-OCT-04.
Verhaegen S, Harris K, Mulryan L, Murphy KJ, Regan CM.; (2004) Screening for Endocrine Disruptors. [Poster Presentation], Irish Neuroscience Group Meeting, Tullamore, Ireland , 26-NOV-04 - 27-NOV-04.
Seymour C.M., Murphy K.J., Regan C.M.; (2003) Glycogen synthase kinase-3beta activity is differentially modulated in the hippocampal dentate gyrus at discrete post-training times following avoidance conditioning. [Poster Presentation], Neuroscience 2003, the Society for Neuroscience 33rd Annual Meeting, New Orleans, Louisiana, United State of America , 08-NOV-03 - 12-NOV-03.
Seymour C.M., Murphy K.J., Saffell J.L., Regan C.M.; (2003) Neural cell adhesion molecule (NCAM) peptide ligands for fibroblast growth factor receptor (FGFR) modulate rodent memory consolidation . [Poster Presentation], Sixth IBRO World Congress of Neuroscience, Prague, Czech Republic , 10-JUL-03 - 15-JUL-03.
Conboy L, OSullivan N, Murphy KJ and Regan CM.; (2005) Degradation of APP during the early phase of long-term memory consolidation. [Poster Presentation], Molecular Mechanisms of Neurodegeneration: a Joint Biochemical Society/Neuroscience Ireland Focused Meeting, O?Reilly Hall, University College Dublin, Ireland , 15-MAR-05 - 16-MAR-05.
Harris KA, Verhaegen S, Murphy KJ and Regan CM.; (2005) Development of an automated screen for analysing the effects of oestrogen compounds on cell fate determination. [Poster Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Thomas CM, Murphy KJ and Regan CM.; (2005) Synaptic modifications underlying memory formation. [Oral Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting. Trinity College Dublin, 7th January, 2005, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Verhaegen S, Harris KA, Mulryan L, Murphy KJ and Regan CM.; (2005) In vitro screening for endocrine disruptors using murine neuronal cell models. [Oral Presentation], Irish Society of Toxicology, Spring Meeting, Nurse Education Building, Ahtlone Institute of Technology , 11-MAR-05 - 12-MAR-05.
Verhaegen S, Harris KA, Mulryan L, Murphy KJ and Regan CM; (2005) In vitro screening for endocrine disruptors using murine neuronal cell models. [Oral Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Mulryan L, Murphy KJ and Regan CM.; (2005) Screening for the detection of endocrine disrupting chemicals. [Poster Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Murphy GK, Mulvany SK, Murphy KJ and Regan CM.; (2005) Memory related synaptic change in the cerebral cortex. [Poster Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Seymour CM, Murphy KJ, Saffell JL and Regan CM.; (2005) Inhibition of ncam-fgfr interaction disrupts avoidance conditioning and associated modulation of gsk3â activity in the rat dentate gyrus. [Poster Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Scully D, Mulvany SK, Murphy KJ and Regan CM.; (2005) Differential neuroplastic marker expression in the dentate gyrus following learning. [Poster Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Seymour CM, Foley AG, Murphy KJ and Regan CM.; (2005) Amnesia induced by antibodies to the neural cell adhesion molecule (NCAM) are only effective for non-spatial forms of learning in the rat. [Poster Presentation], 18th British Neuroscience Association (BNA) National Meeting, Brighton, UK , 03-APR-05 - 06-APR-05.
Thomas CW, Loscher JS, Murphy KJ and Regan CM.; (2005) Minimal change to rodent housing affects behaviour and brain structure. [Poster Presentation], Molecular Mechanisms of Neurodegeneration: a Joint Biochemical Society/Neuroscience Ireland Focused Meeting, O?Reilly Hall, University College Dublin, Ireland , 15-MAR-05 - 16-MAR-05.
Seymour CM, Foley AG, Murphy KJ and Regan CM.; (2005) Amnesia induced by antibodies to the neural cell adhesion molecule (NCAM) are only effective for non-spatial forms of learning in the rat. [Poster Presentation], Molecular Mechanisms of Neurodegeneration: a Joint Biochemical Society/Neuroscience Ireland Focused Meeting, O?Reilly Hall, University College Dublin, Ireland , 15-MAR-05 - 16-MAR-05.
OSullivan NC, Conboy L, Regan CM and Murphy KJ.; (2005) Transcriptional cascades following learning. [Poster Presentation], Royal Academy of Medicine of Ireland (RAMI) Winter Meeting, Trinity College Dublin, Ireland , 07-JAN-05 - 07-JAN-05.
Mulryan L, Murphy KJ and Regan CM.; (2005) Screening for the detection of endocrine disrupting chemicals. [Poster Presentation], Irish Society of Toxicology, Spring Meeting, Nurse Education Building, Ahtlone Institute of Technology, Ireland , 11-MAR-05 - 12-MAR-05.
Harris KA, Verhaegen S, Murphy KJ and Regan CM.; (2005) Development of an automated screening system for analysing the effects of 17-b-estradiol and other oestrogen compounds on cell fate. [Poster Presentation], Irish Society of Toxicology, Spring Meeting, Nurse Education Building, Ahtlone Institute of Technology, Ireland , 11-MAR-05 - 12-MAR-05.
Mulryan L, Verhaegen S, Murphy KJ and Regan CM.; (2004) Development of a High Throughput in vitro screening system for the detection of putative endocrine disruptors. [Poster Presentation], Irish Neuroscience Group Meeting, Tullamore, Ireland , 26-NOV-04 - 27-NOV-04.
Rombach N, Regan C and Murphy K.; (2004) Investigation of brain adaptations underlying addiction. [Poster Presentation], Irish Neuroscience Group Meeting, Tullamore, Ireland , 26-NOV-04 - 27-NOV-04.
Verhaegen S, Harris K, Mulryan L, Murphy KJ and Regan CM.; (2004) Screening for Endocrine Disruptors. . [Poster Presentation], Irish Neuroscience Group Meeting, Tullamore, Ireland , 26-NOV-04 - 27-NOV-04.
Loscher J, Regan CM and Murphy KJ.; (2004) Strain differences in learning induced activation of polysialylated ncam in the hippocampal dentate gyrus. [Poster Presentation], Society for Neuroscience (SFN), 34th Annual Meeting, San Diego , 23-OCT-04 - 27-OCT-04.
Loscher J, Regan CM and Murphy KJ.; (2004) Strain differences in learning-induced activation of polysialylated NCAM in the hippocampal dentate gyrus. [Poster Presentation], Irish Neuroscience Group Meeting, Tullamore, Ireland , 26-NOV-04 - 27-NOV-04.
Murphy KJ, Murphy PM, Conboy L, Moriarty DC and Regan CM.; (2004) 5-HT3 receptor agonism inhibits hippocampal memory consolidation. [Poster Presentation], Federation of European Neuroscience Societies (FENS) Forum 2004, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04.
Murphy KJ, Murphy PM, Conboy L, Moriarty DC and Regan CM.; (2004) 5-HT3 Receptor agonism inhibits hippocampal memory consolidation. [Poster Presentation], Society for Neuroscience (SFN), 34th Annual Meeting, San Diego. , 23-OCT-04 - 27-OCT-04.
OSullivan NC, Conboy L, Regan CM and Murphy KJ.; (2004) Differential temporal modification of gene expression in the rat dentate gyrus following passive avoidance learning. [Poster Presentation], Federation of European Neuroscience Societies (FENS) Forum 2004, Lisbon, Portugal , 10-JUL-04 - 14-JUL-04.
Murphy KJ.; (2004) Introduction to basic neuroscience of memory and learning. [Oral Presentation], Talk series, Systems Biology, National University of Ireland, Maynooth , 15-SEP-04 - 15-SEP-04.
Murphy KJ.; (2004) The Apllied Neurotherapeutics Research Group. [Oral Presentation], Talk series, Systems Biology, National University of Ireland, Maynooth , 23-SEP-04 - 23-SEP-04.
Rombach N, Regan CM and Murphy K.; (2004) Investigation of brain adaptations underlying addiction. [Poster Presentation], Society for Neuroscience (SFN), 34th Annual Meeting, San Diego , 23-OCT-04 - 27-OCT-04.
Thomas CW, Murphy KJ and Regan CM.; (2004) Minimal changes to housing environment significantly affect behavior, memory consolidation, and hippocampal neuroanatomy in the male Wistar rat. [Poster Presentation], Society for Neuroscience (SFN), 34th Annual Meeting. , San Diego , 23-OCT-04 - 27-OCT-04.

Committees

Committee : UCD Biomedical Facilities Management Committee

Employment

Employer: Conway Institute
Position: Appointed Conway Institute Career Track Investigator.
Employer: UCD
Position: Appointed Special Lecturer in Pharmacology
Employer: HRB grant
Position: Personal Post-Doctoral Fellowship
Employer: EU 5th Framework Program
Position: Post-Doctoral Fellowship
Employer: Enterprise Ireland
Position: Post-Doctoral Fellowship
Employer: University College Dublin
Position: Ph.D. research program
Employer: UCD
Position: Postdoctoral Fellow, Dept. of Pharmacology, Conway Institute

Education

Year 2015 Institution: University College Dublin
Qualification: Certificate Subject: Professional Certificate in Teaching&Learning
Year 1994 Institution: University College Dublin
Qualification: BSc Subject: BSc Pharmacology and Mathematics
Year 1997 Institution: University College Dublin
Qualification: PhD Subject: PhD Pharmacology
         

Publications

 

Book Chapters

O'Sullivan NC, Sheridan GK, Murphy KJ; (2012) 'Transcriptional profiling of hippocampal memory-associated synaptic plasticity: Old friends and new faces' In: O'Sullivan NC, Sheridan GK, Murphy KJ; (eds). Transcription Factors CREB and NF-κB: Involvement in Synaptic Plasticity and Memory Formation. E-Book: Bentham. [Details]
Murphy K.J., Gallagher H.C. and Regan C.M.; (2002) 'Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period' In: In: Eds. Wilson S.H. and Suk W.A. Lewis Publishers, CRC Press (eds). Biomarkers of Environmentally associated Disease: Technologies, Concepts, and Perspectives. , pp.211-224 [Details]
Murphy KJ, Fox G.B., O'Connell AW, Regan CM; (1997) 'Time-limited roles for cell adhesion molecule-mediated neuroplastic events in the commitment of memory to long term storage' In: Teelken A.W. and Korf J (eds). Neurochemistry: Cellular, Molecular, and Clinical Aspects. New York: Plenum Publishing Corp. , pp.877-883 [Details]
 

Peer Reviewed Journals

Murphy RP, Murphy KJ, Pickering M (2013) 'The development of myelin repair agents for treatment of multiple sclerosis: Progress and challenges'. Bioengineered, 4 (3):140-146. [Details]
Sheridan GK, Murphy KJ (2013) 'Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre'. Open Biology, 6 (12):130181. [Details]
Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Frigerio CS, Regan CM, Murphy KJ, Masliah E, Walsh DM (2013) 'Alzheimer brain-derived amyloid beta-protein impairs synaptic remodeling and memory consolidation'. Neurobiology of Aging, 34 (5):1315-1327. [DOI] [Details]
Sheridan, G.K., Moeendarbary E., Pickering M., O'Connor J.J., Murphy K.J. (2014) 'Theta-burst stimulation of hippocampal slices induces network-level calcium oscillations and activates analogous gene transcription to spatial learning'. PLoS ONE, 9 (6):e100546-e100546. [DOI] Link to full text [Details]
Sheridan, G.K., Pickering, M., Watters, O., Halley, P.G., O¿Sullivan, N.C., Mooney, C., O¿Connor, J.J., Murphy, K.J. (2014) 'CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity'. Frontiers in Cellular Neuroscience, 8 :233-243. [DOI] Link to full text [Details]
Power BJ, O'Reilly G, Murphy R, Murphy KJ, Pickering M, Jones JF (2014) 'Normal nerve striations are altered in the Trembler-J mouse, a model of'. Muscle & Nerve, . [Details]
Watters, O., Pickering, M., Murphy, R., Murphy, K., O'Connor J.J (2014) 'Automated analysis of intracellular calcium fluorescence in rat organotypic hippocampal cultures: comparison to a manual, observer based method'. Journal of Neuroscience Methods, 223 :20-29. Link to full text [Details]
Power, B.J. and O'reilly, G. and Murphy, R. and Murphy, K.J. and Pickering, M. and Jones, J.F.X. (2015) 'Normal nerve striations are altered in the trembler-J mouse, a model of charcot-marie-tooth disease'. Muscle and Nerve, 51 (2):246-252. Available Online [DOI] [Details]
Cavadas MA, Mesnieres M;Crifo B;Manresa MC;Selfridge AC;Keogh CE;Fabian Z;Scholz CC;Nolan KA;Rocha LM;Tambuwala MM;Brown S;Wdowicz A;Corbett D;Murphy KJ;Godson C;Cummins EP;Taylor CT;Cheong A (2016) 'REST is a hypoxia-responsive transcriptional repressor'. Scientific Reports, 6 . [DOI] [Details]
Scully D, Fedriani R, Desouza IE, Murphy KJ, Regan CM (2012) 'Regional dissociation of paradigm-specific synapse remodeling during memory consolidation in the adult rat dentate gyrus'. Neuroscience, 209 :74-83. [DOI] [Details]
Lukasz B, O'Sullivan NC, Loscher JS, Pickering M, Regan CM, Murphy KJ (2013) 'Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat'. Brain, behavior, and immunity, 27 (1):71-79. [DOI] [Details]
Monopoli MP, Raghnaill MN, Loscher JS, O'Sullivan NC, Pangalos MN, Ring RH, von Schack D, Dunn MJ, Regan CM, Pennington S, Murphy KJ; (2011) 'Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus'. Proteomics, 11 (21):4189-4201. [DOI] [Details]
O'Sullivan NC, Pickering M, Di Giacomo D, Loscher JS, Murphy KJ; (2010) 'Mkl transcription cofactors regulate structural plasticity in hippocampal neurons'. Cerebral cortex (New York, N.Y. : 1991), 20 (8):1915-1925. [DOI] [Details]
Moran, RJ,Stephan, KE,Kiebel, SJ,Rombach, N,O'Connor, WT,Murphy, KJ,Reilly, RB,Friston, KJ; (2008) 'Bayesian estimation of synaptic physiology from the spectral responses of neural masses'. Neuroimage, 42 :272-284. [DOI] [Details]
O'Sullivan, Niamh C. and Croydon, Lawrence and McGettigan, Paul A. and Pickering, Mark and Murphy, Keith J.; (2010) 'Hippocampal region-specific regulation of NF-kappa B may contribute to learning-associated synaptic reorganisation'. BRAIN RESEARCH BULLETIN, 81 (4-5):385-390. [DOI] [Details]
Murphy KJ, ter Horst JPF, Cassidy AW, DeSouza IEJ, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, Lukasz B, Moran MP, McCabe OM, Wantuch CM, Hughes ZA, Mulvany SK, Higgins DG, Pangalos MN, Marquis KL, William T. O'Connor WT, Ring RH, von Schack D, Regan CM; (2010) 'Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat'. Neurochemistry, 113 :601-614. [Details]
Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM; (2010) 'Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation'. Neuroscience, 166 :377-385. [Details]
Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM; (2010) 'Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning'. Behavioural Brain Research, 213 (1):130-134. [DOI] [Details]
McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ; (2010) 'AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity'. Journal of Neurochemistry, 112 :991-1004. [Details]
Regan CM, Seymour CM, Foley AG, Murphy KJ, ; (2008) 'Intraventricular infusions of anti-NCAM PSA impair the process of consolidation of both avoidance conditioning and spatial learning paradigms in Wistar rats'. Neuroscience, 157 (4):813-820. [DOI] [Details]
Riva MA, Frasca A, Fumagalli F, Ter Horst J, Racagni G, Murphy KJ, ; (2008) 'Olanzapine, but not haloperidol, enhances PSA-NCAM immunoreactivity in rat prefrontal cortex'. Neuropsychopharmacology, 11 (5):591-595. [DOI] [Details]
Regan CM, Conboy L, Foley AG, O'Boyle NM, Lawlor M, Gallagher HC, Murphy KJ, ; (2008) 'Curcumin-induced degradation of PKCdelta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats'. Biochemical Pharmacology, 77 (7):1254-1265. [DOI] [Details]
ter Horst JPF, Loscher JS, Regan CM, Murphy KJ. ; (2008) 'Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the prefrontal cortex is region-, cell type- and paradigm-specific'. European Journal of Neuroscience, . [Details]
Pickering M, Pickering BW,Murphy KJ, O'Connor JJ; (2008) 'Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunohistochemical labeling'. Journal of Neuroscience Methods, . [Details]
Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J. ; (2007) 'NFkB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations'. Learning Memory, 14 (8):525-532. [Details]
OSullivan, NC, McGettigan, PA, Sheridan, GK, Pickering, M, Conboy, L, OConnor, JJ, Moynagh, PN, Higgins, DG, Regan, CM, Murphy, KJ, ; (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. Journal of Neurochemistry, 101 :1085-1098. [Details]
Murphy, KJ; Foley, AG; O'Connell, AW; Regan, CM; ; (2006) 'Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing'. Neuropsychopharmacology, 31 (1):90-100. [Details]
Conboy, L; Murphy, KJ; Regan, CM; ; (2005) 'Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation'. Journal of Neurochemistry, 95 (6):1677-1688. [Details]
Foley, AG; Gallagher, HC; Murphy, KJ; Regan, CM; ; (2004) 'Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat'. Neurobiology of Aging, 25 (4):539-546. [Details]
O'Connell, AW; Fox, GB; Kjoller, C; Gallagher, HC; Murphy, KJ; Kelly, J; Regan, CM; ; (2001) 'Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor'. European Journal of Pharmacology, 424 (1):37-44. [Details]
Murphy, KJ; Fox, GB; Foley, AG; Gallagher, HC; O'Connell, A; Griffin, AM; Nau, H; Regan, CM; ; (2001) 'Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe'. Journal of Neurochemistry, 78 (4):704-714. [Details]
Murphy, K.J., Lynch, M.A., and Regan, C.M.; (2001) 'Neuroplastic events required for LTP and avoidance learning are impaired by opiate addiction'. British Journal of Pharmacology, 134 :151. [Details]
Gallagher, H.C., Murphy, K.J., Foley, A.G., and Regan, C.M.; (2001) 'Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain'. Journal of Neurochemistry, 77 :425-434. [Details]
Fox, G.B., Kjøller, C., Murphy, K.J., and Regan, C.M.; (2001) 'The modulations of NCAM polysialylation state that follow transient global ischaemia are brief on neurons but enduring on glia'. Journal of Neuropathology and Experimental Neurology, 60 :132-140. [Details]
O'Malley, A, O'Connell, C, Murphy, KJ, Regan, CM, ; (2000) 'Transient spine density increases in the mid-molecular layer of hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodent'. Neuroscience, 99 (2):229-232. [Details]
Murphy, KJ; Regan, CM; ; (1999) 'Sequential training in separate paradigms impairs second task consolidation and learning-associated modulations of hippocampal NCAM polysialylation'. Neurobiology of Learning and Memory, 72 (1):28-38. [Details]
Ni Dhuill, CM, Fox, GB, Pittock, SJ, O'Connell, AW, Murphy, KJ, Regan, CM, ; (1999) 'Polysialylated neural cell adhesion molecule expression in the dentate gyrus of the human hippocampal formation from infancy to old age'. Neuroscience Research, 55 (1):99-106. [Details]
Murphy, KJ; Regan, CM; ; (1998) 'Contributions of cell adhesion molecules to altered synaptic weightings during memory consolidation'. Neurobiology of Learning and Memory, 70 (1-2):73-81. [Details]
O'Gorman, DA, O'Connell, AW, Murphy, KJ, Moriarty, DC, Shiotani, T, Regan, CM, ; (1998) 'Nefiracetam prevents propofol-induced anterograde and retrograde amnesia in the rodent without compromising quality of anesthesia'. Anesthesiology, 89 (3):699-706. [Details]
Murphy, KJ; O'Connell, A; O'Connell, C; O'Malley, A; Regan, C; ; (1998) 'Contributions of the neural cell adhesion molecule to synaptic plasticity associated with memory consolidation'. Journal of Neurochemistry, 71 (NA):26-26. [Details]
OConnell, AW; Fox, GB; Barry, T; Murphy, KJ; Fichera, G; Foley, AG; Kelly, J; Regan, CM; ; (1997) 'Spatial learning activates neural cell adhesion molecule polysialylation in a corticohippocampal pathway within the medial temporal lobe'. Journal of Neurochemistry, 68 (6):2538-2546. [Details]
Murphy, KJ; Fox, GB; Kelly, J; Regan, CM; ; (1995) 'Influence of toxicants on neural cell adhesion molecule-mediated neuroplasticity in the developing and adult animal: Persistent effects of chronic perinatal low-level lead exposure'. Toxicology Letters, 82-3 (NA):271-276. [Details]
Conboy L, Monopoli MP, O'Sullivan NC, Murphy KJ, Regan CM; (2007) 'Notch signalling is transiently increased during long term memory consolidation in adult wistar rats'. Journal of Neurochemistry, 88 :342-351. [Details]
O'Donnell, RA; Regan, CM; Murphy, KJ; ; (2006) 'Retinoic acid is promnesic in normal animals and reverses cognitive and sensorimotor deficits seen with isolation rearing'. International Journal of Neuropsychopharmacology, 9 (NA):220-221. [Details]
Seymour, CM; Murphy, KJ; Regan, CM; ; (2005) 'Amnesia induced by antibodies to the neural cell adhesion molecule (NCAM)'. Journal of Neurochemistry, 94 (NA):39-39. [Details]
Foley, AG; Murphy, KJ; Regan, CM; ; (2005) 'Complex-environment rearing prevents prenatal hypoxia-induced deficits in hippocampal cellular mechanisms necessary for memory consolidation in the adult Wistar rat'. Neuroscience Research, 82 (2):245-254. [Details]
Sandi C., Merino J.J., Cordero M.I., Kruyt N.D., Regan C.M., Murphy K.J.; (2004) 'Neurobiological and Endocrine Correlates of Individual Differences in Spatial Learning Ability'. Learning Memory, 11 :244-252. [Details]
OLoinsigh E.D., Gherardini L.M., Gallagher H.C., Foley A.G., Murphy K.J., Regan C.M.; (2004) 'Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro'. Journal of Neurochemistry, 88 :370-379. [Details]
Foley, AG; Murphy, KJ; Hirst, WD; Gallagher, HC; Hagan, JJ; Upton, N; Walsh, FS; Regan, CM; ; (2004) 'The 5-HT6 antagonists SB-271046 and SB-399885 increase basal and learning induced hippocampal ncam-polysialylation'. International Journal of Neuropsychopharmacology, 7 (NA):215-215. [Details]
Foley, AG; Murphy, KJ; Hirst, WD; Gallagher, HC; Hagan, JJ; Upton, N; Walsh, FS; Regan, CM; ; (2004) 'The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats'. Neuropsychopharmacology, 29 (1):93-100. [Details]
Foley A.G., Hedigan K., Roullet P., Sara S.J., Murphy K.J., Regan C.M.; (2003) 'Consolidation of odour-reward associative memory involves neural cell adhesion molecule polysialylation-mediated synaptic plasticity within the rodent hippocampus'. Neuroscience Research, 74 :570-576. [Details]
Sandi, C; Merino, JJ; Cordero, MI; Kruyt, ND; Murphy, KJ; Regan, CM; ; (2003) 'Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning'. Biological Psychiatry, 54 (6):599-607. [Details]
Foley, AG; Ronn, LCB; Murphy, KJ; Regan, CM; ; (2003) 'Distribution of polysialylated neural cell adhesion molecule in rat septal nuclei and septohippocampal pathway: Transient increase of polysialylated interneurons in the subtriangular septal zone during memory consolidation'. Neuroscience Research, 74 (6):807-817. [Details]
Fox G.B., Fichera G, Barry T, O'Connell A.W., Murphy K.J., Gallagher H.C. and Regan C.M.; (2000) 'Consolidation of passive avoidance learning is associated with transient increases of polysialylated neurons in layer II of the rat medial temporal cortex'. Neurobiology, 45 :135-141. [Details]
Merino, JJ; Murphy, KJ; Cordero, MI; Kruyt, ND; Venero, C; Regan, C; Sandi, C; ; (2000) 'PSA-NCAM modulation by contextual fear conditioning'. European Journal of Neuroscience, 12 (NA):254-254. [Details]
Murphy K.J. and Regan C.M.; (1999) 'Low-level lead exposure in the early postnatal period results in persisting neuroplastic deficits associated with memory consolidation'. Journal of Neurochemistry, 72 :2099-2104. [Details]
Gratacos, E; Ghelardini, C; Gherardini, LM; Galeotti, N; Murphy, KJ; Bartolini, A; Regan, CM; ; (1998) 'Kv1.1 channel antisense attenuates learning and modulation of dentate polysialylated NCAM'. NeuroReport, 9 (12):2727-2731. [Details]
Odumeru, O; Murphy, KJ; OConnell, AW; Regan, CM; Shiotani, T; ; (1997) 'Influence of nefiracetam on NGF-induced neuritogenesis and neural cell adhesion molecule polysialic acid expression: In vivo and in vitro comparisons'. Behavioural Brain Research, 83 (1-2):173-178. [Details]
Murphy K.J., O' Connell A.W. and Regan C.M.; (1996) 'Repetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multi-trial spatial training'. Journal of Neurochemistry, 67 :1268-1274. [Details]
Fox G.B., O'Connell A.W., Murphy K.J. and Regan C.M.; (1995) 'Memory consolidation induces a transient and time-dependent increase in the frequency of NCAM polysialylated cells in the adult rat hippocampus'. Journal of Neurochemistry, 65 :2796-2799. [Details]

Other Journals

Murphy, K,J., Regan, C.M.; (2006) 'Research update: Applied Neurotherapeutics Research Group, A year of discovery' DMMC News :3-4. [Details]
Murphy, K.J.; (2006) 'Pain and Addiction: A relationship for all time?' PainWise: Irish Journal of Pain Medicine 5 :3-7. [Details]

Conference Publications

O'Shea SD, Keogh EA, Murphy RP, Bowen G, Pickering M, Murphy KJ (2013) Exploring the mechanism of action of the novel remyelinating therapeutic nefiracetam XI European Meeting on Glial Cells in Health and Disease , pp.S135 [Details]
Murphy RP, Keogh EA, O'Shea SD, Bowen G, Pickering M, Murphy KJ (2013) The nootropic agent nefiracetam is a potential remyelinating therapeutic in vivo XI European Meeting on Glial Cells in Health and Disease , pp.S134 [Details]
Keogh EA, O¿Shea SD, Murphy RP, Pickering M, Murphy KJ (2015) The nootropic agent nefiracetam enhances myelin repair XII European Meeting on Glial Cells in Health and Disease Bilbao 2015 Glia issue supplement S1, , pp.E289 [Details]
Murphy RP, Alvey L, Jones J, Murphy KJ, Pickering M (2015) Nefiracetam is ineffective in reversing myelin damage in the trembler-J model of Charcot Marie Tooth disease XII European Meeting on Glial Cells in Health and Disease Bilbao 2015 Glia issue supplement S1, , pp.E292 [Details]
O¿Sullivan NC, Pickering M, Carr F, DiGiacomo D, Loscher JS and Murphy KJ (2009) The transcription cofactor Mkl regulates hippocampal memory-associated neuronal structural reorganisation Neuroscience Ireland [Details]
Sheridan GK, Pickering M, O¿Connor JJ, PN Moynagh and Murphy KJ (2009) Similar temporal oscillations in hippocampal NF-κB following spatial learning in rats and high frequency stimulation of organotypic slice cultures Neuroscience Ireland [Details]
Murphy KJ, Beyer C, Cassidy AW, DeSouza I, Fedriani R, ter Horst JPF, Hughes Z, Logue S, Loscher JS, Marquis K, McCabe O, Moran M, Morgunova M, Mulvany SK, O¿Connor WT, O¿Sullivan NC, Pangalos MN, Ring RH, Rombach N, D. von Schack D, Scully D and Regan CM (2009) Developmental emergence of behavioural, neurochemical, and ultrastructural deficits in a preclinical model of schizophrenia Neuroscience Ireland [Details]
Mulryan LJ, Murphy KJ and Regan CM (2009) Behavioural and transcriptional profiles of rats displaying high and low levels of co-operativity Neuroscience Ireland [Details]
Murphy RP, Murphy KJ and Pickering M (2009) Gut peptide hormones ghrelin and obestatin differentially effect structure and synaptic function of rat hippocampal neurones in vitro Neuroscience Ireland [Details]
Moyna S and Murphy KJ (2009) The enduring effect of cognition enhancing drugs on gene expression in the rodent hippocampus Neuroscience Ireland [Details]
Harris KA, Mulryan LJ, Murphy KJ and Regan CM (2009) Developmental exposure to 17-estradiol does not alter neural cell fate in wistar rats Neuroscience Ireland [Details]
Connole LM, O¿Sullivan NC, Connellan J, Regan CM, Pangalos MN, von Schack D, Beyna M, Ring RH and Murphy KJ (2009) Midkine is a learning-associated peptide with potent effects on hippocampal neurite outgrowth and hippocampal-dependent memory consolidation Neuroscience Ireland [Details]
Sheridan GK, Pickering M, Halley P, O¿Sullivan NC, O¿Connor JJ and Murphy KJ (2009) The chemokine, fractalkine (CX3CL1), modulates synaptic plasticity and is upregulated in the rat hippocampus following a spatial learning task Neuroscience Ireland [Details]
Nic Raghnaill M, Doyle K, Scollard S, Ring RH, Pangalo MN, Regan CM, Pickering M and Murphy KJ (2009) The bone morphogenetic protein inhibitors chordin, gremlin and noggin differentially regulate dendritic structure, neuronal activity and spatial learning Neuroscience Ireland [Details]
O¿Sullivan NC, McGettigan PA, Loftus B and Murphy KJ (2009) Identification of functional gene regulatory elements in the hippocampus of a rat model of schizophrenia using FAIRE-seq Neuroscience Ireland [Details]
O¿Neill T, Pickering M and Murphy KJ (2009) The effect of general anaesthetic agents on hippocampal neuronal structure and psa-ncam expression Neuroscience Ireland [Details]
Lukasz B, O¿Sullivan NC, Loscher JS, and Murphy KJ (2009) Aberrant immune signalling in rodent models of schizophrenia Neuroscience Ireland [Details]
Sheridan, G.K., Pickering, M., Halley, P., O'Sullivan, N.C., O'Connor, J.J., Murphy, K.J. ; (2010) The chemokine, fractalkine (CX3CL1), modulates synaptic plasticity and is upregulated in the rat hippocampus following a spatial learning task Neuroscience Ireland Meeting [Details]
Sheridan, G.K., Pickering, M., O'Connor, J.J., Moynagh, P.N., Murphy, K.J. ; (2010) Similar temporal oscillations in hippocampal NF-kB following spatial learning in rats and high-frequency stimulation of organotypic slice cultures Neuroscience Ireland Meeting, TCD. Irish Journal of Medical Science [Details]
Wdowicz A, Gleize JJ, Bowen G, Murphy KJ, O'Connell DJ (2012) The calcium binding protein secretagogin is expressed in discrete cell populations in the adult rat brain and exhibits age-associated regulation Society for Neuroscience Annual Meeting 2012 [Details]
Sheridan GK, Pickering M, Watters O, Halley PG, O'Sullivan NC, Mooney C, O'Connor JJ, Murphy KJ (2012) CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity Society for Neuroscience Annual Meeting 2012 [Details]
Watters O., O¿Connor J.J., Sheridan G.K., Murphy K.J. & Pickering M. ; (2008) Modulation of glutamate excitotoxicity and ischemic pre-conditioning by TNFα depends on time and order of TNFα and glutamate exposure J. Neuroimmunology, Vol. 197, page 171 [Details]
Mulryan, L.J., Murphy, K.J. and Regan, C.M.; (2006) Differential alterations of spatial learning ability in male and female rats due to perinatal exposure to exogenous estrogens RAMI Section of Biomedical Sciences Winter Meeting University College Dublin, , 12-JAN-06 [Details]
Connole, L., Conboy, L., Regan, C.M. and Murphy, K.J.; (2006) A role for neural molecular guidance molecules ROBO and SLIT in memory-associated hippocampal synaptic reorganization RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Lawlor, M.K., Conboy, L.A., Murphy, K.J., Regan, C.M.; (2006) Design of disease modifying drugs for dementia RAMI Section of Biomedical Sciences Winter Meeting University College Dublin, , 12-JAN-06 [Details]
Sheridan, G., Pickering, M., Moynagh, P.N., O'Connor, J.J. and Murphy, K.J.; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations Royal Academy of Medicine in Ireland, Section of Biomedical Sciences UCD, , 12-JAN-06 [Details]
Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J.; (2006) GABA receptor blockade increases NFκb activation in neuroplastic cells of the rat dentate gyrus while decreasing its activity in more mature granule neurons Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) , pp.78 [Details]
Pickering, B.W., Pickering, M., O'Connor, J.J., Murphy, K.J. ; (2006) The anaesthetic agents propofol and isoflurane differentially effect glutamate-induced calcium influx in primary cultured neurones and glia Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) , pp.40 [Details]
Pickering, M., Pickering, B.W., Murphy, K.J., O'Connor, J.J. ; (2006) Discrimination of neurones and glia using calcium imaging in primary mixed cell culture models of glutamate excitotoxicity Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) , pp.100 [Details]
Sheridan G., Pickering M., Moynagh P.N., O'Connor J.J. and Murphy K.J.; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations British Journal of Pharmacology, Vol 3, Issue 4, 113P [Details]
Rombach, N., Regan, C.M. and Murphy, K.J.; (2005) Investigation of brain adaptations underlying development of a drug-dependent state 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
Thomas, C.M., Murphy, K.J. and Regan, C.M.; (2005) Synaptic modifications underlying memory formation RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Verhaegen, S., Harris, K.A., Mulryan, L., Murphy, K.J. and Regan, C.M.; (2005) In vitro screening for endocrine disruptors using murine neuronal cell models RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
O'Sullivan NC, Conboy L, Regan CM and Murphy KJ ; (2005) Transcriptional events in rat dentate gyrus following passive avoidance learning RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Harris, K.A., Verhaegen, S., Murphy, K.J. and Regan, C.M.; (2005) Development of an automated screen for analysing the effects of oestrogen compounds on cell fate determination RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Conboy, L., Murphy, K.J. and Regan, C.M.; (2005) Degradation of APP during the early phase of long-term memory consolidation 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
O'Sullivan, N.C., Conboy, L., Regan, C.M. and Murphy, K.J.; (2005) Transcriptional regulation following passive avoidance learning 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
Scully, D., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2005) Dorso-ventral expression of polysialylated neural cell adhesion molecule in the rat dentate gyrus following learning RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Scully, D., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2005) Dorso-ventral expression of polysialylated neural cell adhesion molecule in the dentate gyrus following passive avoidance conditioning 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
Scully D, Mulvany SK, Murphy KJ and Regan CM ; (2005) Differential neuroplastic marker expression in the dentate gyrus following learning RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Boyle, K.M., Murphy K. & Callanan J.J.; (2005) MDMA and Caeffeine: a lethal combination British Pharmacology Society , 20-DEC-05 - 20-DEC-05 [Details]
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2005) Long term storage of a passive avoidance task is not associated with synapse change in the secondary visual cortex 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 07-JAN-05 [Details]
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2005) Memory related synaptic change in the cerebral cortex RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Mulryan, L., Murphy, K.J. and Regan, C.M.; (2005) Screening for the detection of endocrine disrupting chemicals. Irish J Med Sci, 174, 30 RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Sheridan, G., Pickering, M., Moynagh, P.N., O'Connor, J.J. and Murphy, K.J.; (2005) The pro-inflammatory cytokine tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations British Pharmacological Society Winter meeting London, , 20-DEC-05 - 22-DEC-05 [Details]
Harris, K.A., Verhaegen, S., Murphy, K.J. and Regan, C.M.; (2005) The development of an automated screening system for analysing the effects of 17-b-estradiol and other estrogenic compounds on stem cell fate 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
Seymour, C.M., Murphy, K.J., Saffell, J.L. and Regan, C.M.; (2005) Inhibition of ncam-fgfr interaction disrupts avoidance conditioning and associated modulation of gsk3β activity in the rat dentate gyrus RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Lukasz, B., O'Sullivan, N., Murphy, K., ; (2008) Aberrant expression of immune signaling-related genes in rodent models of schizophrenia Journal of Neuroimmunology , pp.167-167 [Details]
Lukasz, B., Murphy, K., ; (2008) Aberrant hippocampal expression of immune signalling-related genes in the rodent models of schizophrenia European Neuropsychopharmacology , pp.18-19 [Details]
O'Connor JJ, Watters O, Sheridan GK, Murphy KJ & Pickering M; (2007) TNFalpha-mediated modulation of glutamate excitotoxicity and ischemic preconditioning is time and sequence of TNFalpha and glutamate exposure-dependent Society for Neuroscience Annual Meeting 2007 [Details]
Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J. ; (2006) GABA receptor blockade increases NFκb activation in neuroplastic cells of the rat dentate gyrus while decreasing its activity in more mature granule neurons RAMI [Details]
Pickering, B.W., Pickering, M., O'Connor, J.J., Murphy, K.J. ; (2006) The anaesthetic agents propofol and isoflurane differentially effect glutamate-induced calcium influx in primary cultured neurones and glia RAMI [Details]
O'Sullivan NC, McGettigan PA, Croydon L, Sheridan GK, Pickering M, Ring RH, von Schack D, Higgins DG, Regan CM, Murphy KJ ; (2007) Cell type- and region-specific regulation of nuclear factor kappa-B p65 activity in the hippocampus during consolidation of an avoidance conditioning task Society for Neuroscience Annual Meeting 2007 [Details]
von Schack D, Connole L, Halley P, O'Sullivan NC, Li C, Rombach N, Hill AA, Ford R, Marquis KL, Brown EL, Pangalos MN, Regan CM, Ring RH, Murphy KJ ; (2007) Characterization of temporal transcriptional programs accompanying memory consolidation in the hippocampus Society for Neuroscience Annual Meeting 2007 [Details]
Nic Raghnaill, Monopoli MP, O'Sullivan NC, Loscher JS, Pennington S, Dunn MJ, Regan CM, Murphy KJ ; (2007) Hippocampal protein expression changes associated with consolidation of spatial memory characterised using two dimensional electrophoresis Society for Neuroscience Annual Meeting 2007 [Details]
Halley P, Connole LM, O'Sullivan NC, Loscher JS, Rombach N, Ford R, Ring RH, von Schack D, Pangalos MN, Regan CM, Murphy KJ ; (2007) Alzheimer's disease-associated proteins are regulated at a transcriptional level in the hippocampus during spatial memory consolidation Society for Neuroscience Annual Meeting 2007 [Details]
Monopoli MP, Pennington S, Dunn MJ, Murphy KJ ; (2007) Use of two dimensional electrophoresis to characterise the hippocampal memory consolidation proteome 8th IBRO congress [Details]
ter Horst JPF, Loscher JS, Regan CM, Murphy KJ ; (2007) Expression of NCAM polysialylation in the rat prefrontal cortex in learning and disease 8th IBRO congress [Details]
Loscher JS, Pickering B, Pickering M, Murphy KJ ; (2007) The nootropic nefiracetam prevents isoflurane-induced post-operative cognitive dysfunction (pocd) in aged wistar rats Society for Neuroscience Annual Meeting 2007 [Details]
Connole L, O'Sullivan NC, Connellan J, Regan CM, Marquis KL, Menelas N. Pangalos MN, Bates B, von Schack D, Beyna M, Murphy KJ, Ring RH; (2007) Midkine is a learning-associated peptide with potent effects on hippocampal neurite outgrowth and synaptogenesis Society for Neuroscience Annual Meeting 2007 [Details]
Sheridan G, Pickering M, Moynagh PN, O'Connor JJ, Murphy KJ ; (2007) Temporal changes in nuclear factor kappa-B activity in distinct neuronal subpopulations of the rat hippocampus following spatial learning Society for Neuroscience Annual Meeting 2007 [Details]
Horst, J.P., Regan, C.M. and Murphy, K.J.; (2006) NCAM polysialylation is increased in the prefrontal cortex following spatial learning but not avoidance conditioning RAMI Section of Biomedical Sciences Winter Meeting University College Dublin, , 12-JAN-06 [Details]
Mulryan, L.J., Murphy, K.J. and Regan, C.M.; (2006) Perinatal exposure to exogenous estrogens differentially alters behaviour in adult male and female Wistar rats 5th Forum of European Neuroscience, FENS Vienna, , 08-JUL-06 - 12-JUL-06 [Details]
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2006) Synaptic remodeling underlying long term memory consolidation in the cerebral cortex. Irish J Med Sci, 175, 31 RAMI Section of Biomedical Sciences Winter Meeting University College Dublin, , 12-JAN-06 [Details]
Murphy, G.K., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2006) Synaptic remodeling underlying long term memory consolidation 5th Forum of European Neuroscience, FENS Vienna, , 08-JUL-06 - 12-JUL-06 [Details]
Harris, K.A., Verhaegen, S., Murphy, K.J. and Regan, C.M.; (2006) Determination of the changes in stem cell fate induced by endocrine disruptors through the use of an automated image analysis package RAMI Section of Biomedical Sciences Winter Meeting University College Dublin, , 12-JAN-06 [Details]
Foley, A., Seymour, C.M., Murphy, K.J. and Regan, C.M.; (2005) Amnesia induced by antibodies to the neural cell adhesion molecule 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
Scully, D., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2005) Differential neuroplastic marker expression in the dentate gyrus following learning RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
Scully, D., Mulvany, S.K., Murphy, K.J. and Regan, C.M.; (2005) Dorso-ventral expression of polysialylated neural cell adhesion molecule in the dentate gyrus following passive avoidance conditioning 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
Loscher, J.S., Charlotte, W.T., Murphy, K.J. and Regan, C.M.; (2005) Influence of rat strain and supplier on general behaviour and spatial learning 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
Regan, C.M., Charlotte, W.T., Loscher, J.S. and Murphy, K.J.; (2005) Minimal change to rodent housing affects behaviour and brain structure 37th Annual General Meeting of the European Brain and Behaviour Society Trinity College Dublin, , 24-SEP-05 - 28-SEP-05 [Details]
O'Sullivan, N.C., Conboy, L., Regan, C.M. and Murphy, K.J.; (2005) Transcriptional events in rat dentate gyrus following passive avoidance learning RAMI Section of Biomedical Sciences Winter Meeting Trinity College Dublin, , 07-JAN-05 [Details]
                       

Abstract

Lukasz, B,Loscher, J,O'Sullivan, N,Murphy, K (2008) Aberrant expression of immune signaling-related genes in rodent models of schizophrenia and the effects of immune challenge. Abstract [Details]
O'Neill, T,Pickering, M,Murphy, K (2010) THE EFFECT OF GENERAL ANAESTHETIC AGENTS ON HIPPOCAMPAL NEURONAL STRUCTURE AND PSA-NCAM EXPRESSION. Abstract [Details]
Foley A.G., Murphy K.J., Hirst W.D., Gallagher H.C., Hagan J.J., Upton N., Walsh F.S. and Regan C.M.; (2004) The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Abstract [Details]
Conboy L., Murphy K.J. and Regan C.M.; (2002) Degradation of rat hippocampal APP is associated with increased LRP expression and LRP association with LRP during the early phases of memory consolidation. Abstract [Details]
Sandi C., Cordero M.I., Lopez-Fernandez M.A., Venero C., Merino J.J., Kruyt N.D., Regan C.M. and Murphy K.J.; (2004) Hippocampal and endocrine correlates of individual differences in spatial learning abilities. Abstract [Details]
Murphy K.J., Murphy P.M., Conboy L., Moriarty D.C. and Regan C.M.; (2004) 5-HT3 receptor agonism inhibits hippocampal memory consolidation. Abstract [Details]
OSullivan N.C., Conboy L., Regan C.M. and Murphy K.J.; (2004) Differential temporal modification of gene expression in the rat dentate gyrus following passive avoidance learning. Abstract [Details]
ODonnell R.G., Murphy K.J. and Regan C.M.; (2003) Promnesic actions of retinoic acid in avoidance conditioning and spatial learning paradigms. Abstract [Details]
Foley A.G., Murphy K.J., Hirst W.D., Gallagher H.C., Hagan J.J., Upton N., Walsh F.S. and Regan C.M.; (2003) The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Abstract [Details]
Murphy K.J. and Regan C.M.; (2003) Memory-specific modulation of deoxyglucose utilisation during the consolidation of an avoidance conditioning task in the adult Wistar rat. Abstract [Details]
Seymour C.M., Murphy K.J., Saffell J.L. and Regan C.M.; (2003) Neural cell adhesion molecule (NCAM) peptide ligands for fibroblast growth factor receptor (FGFR) modulate rodent memory consolidation. Abstract [Details]
Regan C.M., Foley A.G., Murphy K.J., Hirst W.D., Gallagher H.C., Hagan J.J., Upton N. and Walsh F.S.; (2003) The 5-HT6 receptor antagonists SB-271046 and SB-399885 increase basal and learning induced NCAM-polysialylation in the rat dentate gyrus. Abstract [Details]
Seymour C.M., Murphy K.J. and Regan C.M.; (2003) Glycogen synthase kinase-3b activity is differentially modulated in the hippocampal dentate gyrus at discrete post-training times following avoidance conditioning. Abstract [Details]
ODonnell R.G., Murphy K.J. and Regan C.M.; (2003) Retinoic acid displays promnesic activity in avoidance conditioning and spatial learning paradigms. Abstract [Details]
Conboy L., Murphy K. and Regan C.; (2002) Degradation of rat hippocampal APP is associated with increased LRP expression and LRP association with ApoE during the early phases of memory consolidation. Abstract [Details]
O'Loinsigh E., Foley A.G., Murphy K.J. and Regan C.M.; (2002) Isolation rearing of rats produces deficits in prepulse inhibition of acoustic startle response, but does not affect performance in a working memory task. Abstract [Details]
Rombach N., Murphy K.J. and Regan C.M.; (2002) Hippocampal adaptation following acute exposure to drugs of abuse. Abstract [Details]
OLoinsigh E., Foley A.G., Murphy K.J. and Regan C.M.; (2002) Isolation rearing of rats produces deficits in prepulse inhibition of the acoustic startle response but not in a delayed match-to-position task. Abstract [Details]
Mulvany S., Murphy K.J. and Regan C.M.; (2002) Cerebellar NCAM polysialylation characterisation in the juvenile and adult wistar rat. Abstract [Details]
Murphy K., Rombach N. and Regan C.; (2002) Hippocampal adaptation following acute exposure to drugs of abuse. Abstract [Details]
Mulvany S., Murphy K.J. and Regan C.M.; (2001) NCAM polysialylation is maintained in a pattern of discrete zones in the adult rat cerebellum. Brit. Neurosci. Abstract [Details]
Sandi C., Merino J.J., Cordero M.I., Kruyt N.D., Touyarot K., Murphy K.J. and Regan C.M.; (2001) Differential regulation of PSA-NCAM in the hippocampus of rats with different spatial learning abilities. Abstract [Details]
Merino J.J., Murphy K.J., Cordero M.I., Kriyt N.D., Venero C., Regan C. and Sandi C.; (2001) PSA-NCAM modulation by contextual fear conditioning. Abstract [Details]
Murphy K.J., Lynch M.A. and Regan C.M.; (2000) Opiate addiction impairs activation of neuroplastic events required for LTP and avoidance learning. Abstract [Details]
ODonovan M., Schuur A.G., ten Bruggencate S.J.M., Murphy K.J., Foley A., Bacon C.L., Brouwer A. and Regan C.M.; (2000) Prenatal exposure to organohalogens fails to affect brain development or learning in rodents. Abstract [Details]
ODonovan M., Schuur A.G., ten Bruggencate S.J.M., Murphy K.J., Foley A., Bacon C.L., Brouwer A. and Regan C.M.; (2000) Perinatal OC exposure in the wistar rat: evidence for a hippocampal-independent mechanism of action. Abstract [Details]
Merino J.J., Murphy K.J., Codero M.I., Kruyt N.D., Venero C., Regan C. and Sandi A.; (2000) PSA-NCAM modulation by contextual fear conditioning. Abstract [Details]
Murphy K.J., Lynch M.A. and Regan C.M.; (2000) Opiate addiction impairs neuroplastic events associated with memory formation. Abstract [Details]
Murphy K.J. and Regan C.M.; (1999) Low-level lead exposure in the early post-natal period results in persisting neuroplastic deficits associated with memory consolidation. Abstract [Details]
Foley A.G., Murphy K.J., OConnell A.W., Shiotani T. and Regan C.M.; (1999) Chronic administration of cognition-enhancing drugs parallels the improved neuroplasticity arising from complex environment rearing. Abstract [Details]
Murphy K.J. and Regan C.M.; (1998) Learning to withdraw from heroin addiction. Abstract [Details]
Murphy K.J., Fox G.B., Ehlers K., O'Connell A.W., Drews E., Nau H. and Regan C.M.; (1998) Pentynoic acid analogues are anti-amnesic and attenuate age-dependent loss of neuroplastic potential in rodents. Abstract [Details]
Foley A.G., Murphy K.J., O'Connell A.W., Shiotani T. and Regan C.M.; (1998) Chronic administration of cognition-enhancing drugs parallels the improved neuroplasticity arising from complex environment rearing. Abstract [Details]
Murphy K.J., OConnell A., OConnell C., OMalley A. and Regan C.M.; (1998) Contributions of the neural cell adhesion molecule to synaptic plasticity associated with memory consolidation. Abstract [Details]
Regan C.M., OGorman D.A., OConnell A.W., Murphy K.J., Moriarty D.C., Watabe S. and Shiotani T.; (1997) Nefiracetam prevents propofol-induced anterograde and retrograde amnesia in the rodent without conpromising anaesthetic quality. Abstract [Details]
Murphy K.J., O' Connell A.W. and Regan C.M.; (1996) Repetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multi-trial spatial training. Abstract [Details]
O'Connell A.W., Fox G.B., Murphy K.J. and Regan C.M.; (1996) Learning-induced modulations of NCAM polysialylation state. Abstract [Details]
Regan C.M., Fox G.B., Murphy K.J. and OConnell A.W.; (1996) Transient NCAM polysialylation during memory consolidation is a universal feature of spatial and non-spatial learning. Abstract [Details]
Fox G.B., Murphy K.J., OConnell A.W. and Regan C.M.; (1996) Morphological substrates for NCAM-mediated events in long-term memory consolidation. Abstract [Details]
Shiotani T., Watabe S., Odumeru O., Murphy K.J., OConnell A.W. and Regan C.M.; (1996) Influence of nefiracetam on NGF-induced neuritogenesis and neural cell adhesion molecule polysialic acid expression: In vivo and in vitro comparisons. Abstract [Details]
Fox G.B., O'Connell A.W., Murphy K.J., Fichera G. and Regan C.M.; (1995) Time-dependent increase in polysialylated cells in the hippocampus and perirhinal cortex following learning in the adult rat. Abstract [Details]
                                                       

Articles

Murphy K.J., Fox G.B., OConnell A.W. and Regan C.M.; (1997) Time-limited roles for cell adhesion molecule-mediated neuroplastic events in the commitment of memory to long term storage. In: Neurochemistry: Cellular, Molecular, and Clinical Aspects. Articles [Details]
                             

Research

Research Interests

My research group, the Neurotherapeutics Research Group, is dedicated to the identification of novel drug targets for the treatment of neurological and neurodegenerative diseases such as schizophrenia, drug addiction, Alzheimer's disease and multiple sclerosis. We bring several different approaches together to address this challenge including animal models of behaviour, in vivo site-directed interruption of function with shRNA, in vitro cell and slice culture techniques, confocal microscopy, DNA microarray and proteomics.

Research Projects

Sponsor : The Wellcome Trust (WT)
Title : The role of Wnt signalling in racetam-mediated myelin repair
Start Date / End Date : 10-JUN-13 / 30-AUG-13
Sponsor : Science Foundation Ireland (SFI)
Title : Characterisation of a novel biomarker panel for clinical and preclinical neurotherapeutics
Start Date / End Date : 01-JAN-13 / 31-MAY-14
Sponsor : University College Dublin (UCD)
Title : Infection Biology Scholarships & Research Costs
Start Date / End Date : 01-JUL-15 / 30-SEP-16
Sponsor : Irish Research Council (IRC)
Title : Investigating the psychedelic agent 5-Methoxy-N,N-dimethyltryptamine as a potential novel treatment for drug addiction
Start Date / End Date : 04-JAN-16 / 03-JAN-20
Sponsor : Royal Embassy of Saudi Arabia
Title : Exploring the role and regulation of a novel memory-associated gene cluster in the hippocampus towards development of a novel, nanoparticle-based cognition-enhancing therapy
Start Date / End Date : 20-OCT-15 / 31-AUG-17
Sponsor : Irish Research Council (IRC)
Title : Exploring the biology of a novel remyelinating drug class
Start Date / End Date : 01-SEP-12 / 31-AUG-15
Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MolCellBiol - Split Accounts School of BBS
Start Date / End Date : 01-MAR-11 / 31-DEC-16
Sponsor : US Dept. of Defense (DoD)
Title : A Novel First-in-Class Therapy for Multiple Sclerosis
Start Date / End Date : 01-JUL-11 / 31-MAR-15
Sponsor : Muscular Dystrophy Society of Ireland
Title : Novel treatment for Charcot-Marie-Tooth disease
Start Date / End Date : 01-MAR-11 / 29-FEB-12
Sponsor : Enterprise Ireland (EI)
Title : Racetams as Novel Myelin Organisation Repair treatments for Multiple Sclerosis (NoMoreMS)
Start Date / End Date : 01-APR-11 / 31-MAR-12
Sponsor : University College Dublin (UCD)
Title : Developing a Novel Treatment for Charcot Marie Tooth disease
Start Date / End Date : 17-MAY-10 / 16-NOV-11
Sponsor : Multiple Sclerosis Society of Ireland
Title : In-vitro assessment of the efficacy of the nootropic nefuracetan to enhance plasticity after experimental demyelination
Start Date / End Date : 02-FEB-09 / 01-FEB-10
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Characterising transcriptional control of normal cognitive function and disease-associated dysfunction: role of transcriptional co-factor Mal-1
Start Date / End Date : 01-OCT-08 / 30-SEP-11
Sponsor : Science Foundation Ireland (SFI)
Title : The development of an automated in vitro screening system for detection of endocrine disrupting potential on reproduction and cognitive function
Start Date / End Date : 01-MAY-06 / 30-APR-09
Sponsor : Science Foundation Ireland (SFI)
Title : Applied Neurotherapeutics Research Group - Murphy
Start Date / End Date : 01-JAN-04 / 31-MAR-08

Recent Postgraduates

  • Dr Siobhan Moyna
  • Dr Marco Monopoli
  • Dr Laura Connole
  • Dr Paul Halley
  • Dr Judith ter Horst
  • Dr Graham Sheridan
  • Dr Michelle Nic Raghnaill
  • Dr Bart Lukasz
  • Dr Tanya O'Neill
  • Dr Brian Pickering
  • Dr Danielle Corbett
  • Dr Robert Murphy
  • Dr Carol Chan
  • Dr Anita Wodowizc

Current Postgraduate Students

Josiah O Sullivan, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Sarah Abdulmalek, Doctor of Philosophy (PhD)   -   Secondary Supervisor
Elaine Keogh, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201600   PHAR40070     Pharmacology: Adv neuropharmacology
201600   PHAR30050     Pharmacology: Molecular pharmacology
       

Collaborators

Internal Collaborators

  • Prof Gil Lee
  • Assoc Prof Brian Rodriguez
  • Dr Emmanuel Raynaud
  • Dr David O'Connell
  • Dr Gerard Cagney

External Collaborators

  • Prof Dominic Walsh (Harvard)
  • Prof Michael Hutchinson and Dr Chris McGuigan (St Vincent's University Hospital)
  • Dr Saito (Osaka, Japan)
  • Prof David Cotter (neurologist, RCSI)