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Orina Belton

Associate Professor

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166748
Email: orina.belton@ucd.ie

Biography


Appointments


2016- Associate Professor,  School of Biomolecular and Biomedical Science, UCD

2014-2016: Senior Lecturer (Pharmacology), SBBS, UCD

2007-2013:  Lecturer (Pharmacology), SBBS, UCD

2004-2007:  Principal Investigator, SMMS, UCD

2003-2004:  Research Manager/Research Fellow, RCSI, Dublin

2001-2003:  Locum Lecturer, Clinical Pharmacology, RCSI, Dublin

1999-2003:  Postdoctoral Research Fellow, RCSI, Dublin

1995-1999:  Postgraduate student, Department of Clinical Pharmacology, RCSI, Dublin

1994-1995:  Research Assistant, Cell and Molecular Biology Group, NUIG, Galway




 

 Research Links: Research in SBBS  |  Mechanisms of Disease Research in SBBS  |  Model Organisms in SBBS 

Professional

Honours and Awards

Year: 2015.
Title: SMMS Teacher of the Year Award BHLS
Year: 2014.
Title: SMMS Teacher of the Year Award BHLS
Year: 2011.
Title: SMMS Teacher of the Year Award

Associations

Association: American Heart Association, Function/Role: Professional Member
Association: Council on Council on Atherosclerosis, Thrombosis and Vascular Biology (ATVB), Function/Role: Member
Association: European Atherosclerosis Society (EAS), Function/Role: Member
Association: International Atherosclerosis Society (IAS), Function/Role: Member

Patents

Patent WO 2009/127398 : CONJUGATED LINOLEIC ACID DERIVATIVES
   

Conference Contributions

Orina Belton (2011) CLA: Biological effects in atherosclerosis. [Invited Oral Presentation], International School of Pharmacology Eicosanoids in cardiovascular disease, Ettore Majorana Foundation and Centre for the Scientific Culture Erice, Sicily , 19-JUN-12 - 23-JUN-11.
Paola Patrignani, Dieter Steinhilber, Orina Belton (2012) Conference Co-organiser. [Conference Organising Committee Member], International Summer School on Lipid Signaling, University of Chieti, Italy , 30-SEP-12 - 02-OCT-12.
Orina Belton (2013) [Poster Presentation], Gordon Research Conference Atherosclerosis, Vermont, USA , 16-JUN-13 - 21-JUN-13.
Orina Belton (2013) Alteration of monocyte function in the regression of atherosclerosis. [Oral Presentation], Gordon Research Conference Atherosclerosis, Vermont, USA , 16-JUN-13 - 21-JUN-13.
Orina Belton (2014) Invited Speaker. [Invited Oral Presentation], International School of Pharmacology Eicosanoids and Related Compounds, Centre for Scientific Culture, Sicily, Italy , 02-SEP-14 - 07-SEP-14.
Patricia Maguire, Orina Belton (2014) Co-organiser. [Conference Organising Committee Member], Annual Irish Area Section Biochemical Society Meeting, University College Dublin , 13-NOV-14 - 14-NOV-14.
Orina Belton (2015) Resolution of inflammation and atherosclerosis - a focus on conjugated linoleic acids. [Invited Oral Presentation], International School of Pharmacology Nutraceuticals, Erie, Sicily , 26-SEP-15 - 30-SEP-15.
Orina Belton (2016) [Invited Oral Presentation], Astra Zeneca External Research Summit, Madrid, Spain , 23-NOV-16 - 25-NOV-16.
Orina Belton (2017) [Oral Presentation], Complications of Diabetes and Obesity Symposium, University College Dublin , 11-JAN-17 - 13-NOV-17.
Catherine Godson [Chair] Orina Belton John Crean Neil Docherty Carel leRoux Fiona McGillicuddy Donal O¿Shea Helen Roche (2017) Co-organiser of Conference. [Conference Organising Committee Member], Complications of Diabetes and Obesity Symposium, University College Dublin , 11-JAN-17 - 13-JAN-17.
   

Education

Year 1999 Institution: University College Dublin
Qualification: PhD Subject:
Year 1994 Institution: NUI Galway, IRL
Qualification: BSc Subject:
     

Journals Edited

Frontiers In Pharmacology: Editorial Board member.
 

Publications

 

Book Chapters

McClelland S, Cox C, O' Connor R, Fitzgerald D, Belton O (2009) 'Identification of novel anti-atherosclerotic effects of conjugated linoleic acid in vascular cells' In: Asher Kimchi (eds). Current Advances in Heart Disease. Canada: International Proceedings Division. [Details]
Belton O, McClelland S, Fitzgerald D (2008) 'Cycloxygenase inhibition in atherothrombotic disease' In: Dominick J. Angiolillo, Adnan Kastrati, Daniel Simon (eds). A Clinical Guide to the use of Antithrombotic Drugs in Coronary Artery Disease. London: Informa Healthcare. [Details]
Maguire PB, Belton O, O'Donoghue N & Coppinger JC. (2006) 'Platelet-endothelial interactions' In: Aird, W.C (eds). The Endothelium: A Comprehensive Reference. Cambridge, UK: Cambridge Univerity Press. [Details]
Belton O, Forde R, Lorez HP, Fitzgerald DJ. ; (1998) 'Cyclooxygenase expression in a rat model of focal cerebral ischemia' In: Belton O, Forde R, Lorez HP, Fitzgerald DJ. ; (eds). Essential Fatty Acids and Eicosanoids. *: AOCS Press. , pp.61-63 [Details]
McClelland S, Cox C, O' Connor R, Fitzgerald D, Belton O (2009) 'Identification of novel anti-atherosclerotic effects of conjugated linoleic acid in vascular cells' In: Asher Kimchi (eds). Current Advances in Heart Disease. Canada: International Proceedings Division. [Details]
 

Peer Reviewed Journals

Bruen R, Fitzsimons S, Belton O (2017) 'Atheroprotective Effects of Conjugated Linoleic Acid'. British Journal of Clinical Pharmacology, 83 (1):46-53. [DOI] [Details]
Bruen R, Curley S, Kajani S, Crean D, O'Reilly ME, Lucitt MB, Godson CG, McGillicuddy FC, Belton O. (2017) 'Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis'. Cardiovascular Diabetology, 16 (1):143-156. [Details]
McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP, Crean D (2017) 'NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells'. Frontiers in Immunology, 8 (7). [DOI] [Details]
Marcone S, Belton O, Fitzgerald DJ. (2017) 'Milk-derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis'. British Journal of Clinical Pharmacology, 83 (1):152-162. [DOI] [Details]
Brennan E; Wang B; McClelland A; Mohan M; Marai M; Beuscart O; Derouiche S; Gray S; Pickering R; Tikellis C; de Gaetano M; Barry M; Belton O; Ali-Shah ST; Guiry P; Jandeleit-Dahm KA; Cooper ME; Godson C; Kantharidis P (2017) 'Protective Effect of Let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis'. Diabetes, 66 (8):2266-2277. [DOI] [Details]
de Gaetano M, Crean D, Barry M, Belton O. (2016) 'M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis'. Frontiers in Immunology, 7 (275). [DOI] [Details]
Marcantoni E, Dovizio M, O Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O (2015) 'Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1'. Prostaglandins and Other Lipid Mediators, 120 :103-114. [DOI] [Details]
Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P (2015) 'Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells'. British Journal of Pharmacology, 172 (18):4575-4587. [DOI] [Details]
Marcone S, Haughton K, Simpson PJ, Belton O, Fitzgerald DJ (2015) 'Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-gamma dependent regulation of NF-kB'. Journal of Inflammation, 12 (1). [DOI] [Details]
de Gaetano M, Alghamdi K, Marcone S, Belton O (2015) 'Conjugated linoleic acid induces an atheroprotective macrophage M2 phenotype and limits foam cell formation'. Journal of Inflammation, 12 (15). [DOI] [Details]
McCarthy C, Lieggi NT, Barry D, Mooney D, de Gaetano M, James WG, McClelland S, Barry MC, Escoubet-Lozach L, Li AC, Glass CK, Fitzgerald DJ, Belton O (2013) 'Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid'. EMBO Molecular Medicine, 5 (9):1443-1457. [DOI] [Details]
de Gaetano M, Dempsey E, Marcone S, James WG, Belton O (2013) 'Conjugated linoleic acid targets Beta2 integrin expression to suppress monocyte adhesion'. Journal of Immunology, 191 (8):4326-4336. [DOI] [Details]
McCarthy, C,Duffy, MM,Mooney, D,James, WG,Griffin, MD,Fitzgerald, DJ,Belton, O (2013) 'IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis'. FASEB Journal, 27 :499-510. [DOI] [Details]
Reynolds, CM, Toomey, S, McBride, R, McMonagle, J, Morine, MJ, Belton, O, Moloney, AP, Roche, HM (2013) 'Divergent effects of a CLA-enriched beef diet on metabolic health in ApoE(-/-) and ob/ob mice'. Journal of Nutritional Biochemistry, 24 :401-411. [DOI] [Details]
Mooney D, McCarthy C, Belton O (2012) 'Effects of conjugated linoleic acid isomers on monocyte, macrophage and foam cell phenotype in atherosclerosis'. Prostaglandins and Other Lipid Mediators, 98 (4):56-62. [DOI] [Details]
Duffy MM, Pindjakova J, Hanley SA, McCarthy C, Weidhofer GA, Sweeney EM, English K, Shaw G, Murphy JM, Barry FP, Mahon BP, Belton O, Ceredig R, Griffin MD; (2011) 'Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'. Journal of Immunology, 41 (10):2840-2851. [DOI] Link to full text [Details]
McCarthy, C,O'Gaora, P,James, WG,McClelland, S,Fitzgerald, DJ,Belton, O,de Gaetano, M; (2010) 'SorLA modulates atheroprotective properties of CLA by regulating monocyte migration'. Atherosclerosis, 213 :400-407. [DOI] [Details]
McClelland, S,Cox, C,O'Connor, R,de Gaetano, M,McCarthy, C,Cryan, L,Fitzgerald, D,Belton, O; (2010) 'Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell'. Atherosclerosis, 211 :96-102. [DOI] [Details]
McClelland, S,Gawaz, M,Kennerknecht, E,Konrad, CSI,Sauer, S,Schuerzinger, K,Massberg, S,Fitzgerald, DJ,Belton, O; (2009) 'Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse'. Atherosclerosis, 202 (NA):84-91. [DOI] [Details]
McClelland, SE, OConnor, R, Buckmaster, PE, Fitzgerald, DJ, Belton, OA, ; (2007) 'Conjugated linoleic acid alters the pro-atherosclerotic phenotype of the monocyte/macrophage - Evidence for the involvement of a novel signalling pathway'. Atherosclerosis Supp, 8 :42-42. [Details]
Toomey, S,Harhen, B,Roche, HM,Fitzgerald, D,Belton, O; (2006) 'Profound resolution of early atherosclerosis with conjugated linoleic acid'. Atherosclerosis, 187 :40-49. [DOI] [Details]
Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ & Maguire PB; (2004) 'Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions'. Blood, 103 :2096-2104. [Details]
Pidgeon GP, Tamosiuniene R, Chen G, Leonard I, Belton O, Bradford A, Fitzgerald DJ.; (2004) 'Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2'. Circulation, 110 (17):2701-2707. [Details]
Belton O, Duffy A, Toomey S, Fitzgerald DJ.; (2003) 'Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis'. Circulation, 108 (24):3017-3023. [Details]
Belton O, Fitzgerald DJ. ; (2003) 'Cyclooxygenase isoforms and atherosclerosis'. Expert Rev Mol Med, :1-18. [Details]
Murphy JF, Steele C, Belton O, Fitzgerald DJ.; (2003) 'Induction of cyclooxygenase-1 and -2 modulates angiogenic responses to engagement of alphavbeta3'. British Journal of Haematology, 121 (1):157-164. [Details]
Belton O, Fitzgerald D.; (2003) 'Cyclooxygenase-2 inhibitors and atherosclerosis'. Journal of the American College of Cardiology, 41 (10):1820-1822. [Details]
Toomey S, Roche H, Fitzgerald D, Belton O.; (2003) 'Regression of pre-established atherosclerosis in the apoE-/- mouse by conjugated linoleic acid'. Biochemical Society Transactions, 31 (5):1075-1079. [Details]
Duffy T, Belton O, Bresnihan B, FitzGerald O, FitzGerald D; (2003) 'Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis'. Drugs, 63 (Suppl 1):31-36. [Details]
Connolly E, Bouchier-Hayes DJ, Kaye E, Leahy A, Fitzgerald D, Belton O; (2002) 'Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty'. Journal of Pharmacology and Experimental Therapeutics, 300 (2):393-398. [Details]
Belton, O.,Byrne, D.,Kearney, D.,Leahy, A.,Fitzgerald, D. J.; (2000) 'Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis'. Circulation, 102 (8):840-5. [Details]
 

Conference Publications

L Akijian, M Marnane, C Mcdonnell, C Whelan, M De Gaetano, G Horgan, EM Fallon, O Belton, M Fitzgibbon, PJ Kelly (2015) Experimental/translational Medicine Inflammatory biomarkers associated with acute symptomatic carotid atherosclerosis in the Dublin Carotid Atherosclerosis and Stroke Study (ducass) . In: Stroke, February 2015, Volume 46, Issue Suppl 1 eds. American Heart Association/American Stroke Association Nashville, USA, , 11-FEB-15 - 13-FEB-15 [Details]
McCarthy C, Duffy M, Mooney D, James W, Fitzgerald DJ, Griffin MD, Belton O, (2012) Il-10 Regulates the Immunoregulatory Response in the Regression of Atherosclerosis . In: ATVB, 2012, Vol 32 A1-150 eds. Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference Chicago, USA, , 18-APR-12 - 20-APR-12 [Details]
McCarthy C, Mooney D, de Gaetano M, James W, Fitzgerald DJ, Belton O (2012) Activation of the Nuclear Receptor Coactivator PGC-1{alpha} Mediates an Atheroprotective Effect Circulation Research [Details]
Monica de Gaetano, Eugene Dempsey, Simone Marcone, Desmond J Fitzgerald, Orina Belton (2012) Conjugated Linoleic Acid Targets β2 Integrin Expression to Suppress Monocyte Adhesion . In: Circulation 2012 126: Suppl 21, 18596 eds. American Heart Association Los Angeles, USA, , 03-NOV-12 - 07-NOV-12 [Details]
Mooney DM, barry D,Lieggi N, McCarthy C, Fitzgerald DJ, Belton O (2011) A potential atheroprotective role of PGC1α in monocytes and macrophage derived foam cells Atherosclerosis Thrombosis vascular Biology [Details]
McCarthy C, Fitzgerald DJ, Belton O, (2011) Modulation of Il-10 Signalling Pathway Is a Potential Mediator of Regression of Atherosclerosis Atherosclerosis Thrombosis Vascualr Biology [Details]
McCarthy C, Mooney D, Fitzgerald DJ, Belton O ; (2010) Identification of a PGC1a regulated network induced by conjugated linoleic acid in the regression of atherosclerosis Atherosclerosis Thrombosis and Vascular Biology [Details]
McCarthy C, James W, Fitzgerald DJ, Belton O ; (2010) Novel regulation and recognition of the role of SorLA in atherosclerotic vasculature Keystone Symposia Advances in Molecular Mechanisms in Atherosclerosis 2010 [Details]
E Napoleone, G Colavecchia, A Cutrone, D Cugino, L Iacoviello, G de Gaetano, O Belton, MB Donati, R Lorenzet (2009) EFFECT OF CONJUGATED LINOLEIC ACID ISOMERS ON TF EXPRESSION IN HUMAN MACROPHAGES Nutrition Metabolism and Cardiovascular Disease [DOI] [Details]
McCarthy C, Cox C, Belton O (2009) Conjugated linoleic acid reduces expression of migratory regulator of Sorl1 in the vasculature Atherosclerosis Supplements [Details]
Lieggi N, McClelland S, Fitzgerald DJ, Belton O (2008) Conjugated Linoleic Acid Inhibits Macrophage Foam Cell Formation Atherosclerosis Thrombosis Vascular Biology [Details]
Cox C, Guisot N Devocelle, Fitzgerald DJ, Belton O (2008) ATVB 2008 Nitrosylated Conjugated Linoleic Acid: A Novel Antiatherogenic and Antiplatelet Agent Atherosclerosis Thrombosis vascular Biology [Details]
McClelland S, Ballou L, Fitzgerald D, Belton O; (2007) COX-2 gene deletion increases advanced aortic arch atherosclerosis in the apoE-/- mouse model Atherosclerosis Thrombosis and Vascular Biology [Details]
McClelland S, Fitzgerald D, Belton O; (2007) Conjugated linoleic acid alters the pro-atherosclerotic phenotype of the monocyte/macrophage- evidence for the involvement of a novel signalling pathway European Atherosclerosis Society 76th Congress [Details]
Belton O, McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, ; (2007) Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse Atherosclerosis Thrombosis Vascular Biology [DOI] [Details]
McClelland, SE, Ballou, LR, Fitzgerald, DJ, Belton, OA, ; (2007) COX-2 gene deletion increases advanced aortic arch atherosclerosis in the apoE-/- mouse model Atherosclerosis, Thrombosis, Vascular Biology Chicago, USA, , 19-APR-07 - 21-NOV-07 [Details]
McClelland SE, O'Connor R, Buckmaster P, Fitzgerald DJ, Belton O (2007) Conjugated linoleic acid alters the pro-atherosclerotic phenotype of the monocyte/macrophage - evidence for the involvement of a novel signalling pathway Atherosclerosis Supplements [Details]
Toomey S, Dooley C, Sharkey C, Fitzgerald D, Belton O; (2004) The effect of a novel inhibitor of the peroxidase activity of cyclooxygenase-1 on the development of atherosclerosis Atherosclerosis Thrombosis and Vascular Biology [Details]
McClelland S, Fitzgerald D, Langenbach R, Belton O; (2004) Cyclooxygenase-1 Gene Deletion Inhibits Atherosclerosis in the ApoE-/- Mouse Atherosclerosis Thrombosis and Vascular Biology [Details]
Toomey S, Roche H, Fitzgerald D, Belton O; (2003) Profound resolution of atherosclerotic lesions by the 9-cis, 11-trans isomer of conjugated linoleic acid Atherosclerosis Thrombosis and Vascular Biology [Details]
Duffy A, Fitzgerald D, Belton O; (2001) Inhibition of cyclooxygenase isoforms and the development of atherosclerosis Circulation (American Heart Association) [Details]
Connolly E, Leahy A, Fitzgerald D, Belton O; (2000) Effect of selective Cyclooxygenase-1 and '2 inhibition on intimal hyperplasia in a rat model of balloon angioplasty Circulation (American Heart Association) [Details]
                                         

Abstract

McCarthy, C,Mooney, D,de Gaetano, M,James, W,Fitzgerald, DJ,Belton, O (2012) Activation of the Nuclear Receptor Coactivator PGC-1 alpha Mediates an Atheroprotective Effect. Abstract [Details]
McCarthy, C,Duffy, M,Mooney, D,James, W,Fitzgerald, DJ,Griffin, MD,Belton, O (2012) Il-10 Regulates the Immunoregulatory Response in the Regression of Atherosclerosis. Abstract [Details]
McCarthy, C,Cox, C,Belton, O (2009) CONJUGATED LINOLEIC ACID REDUCES EXPRESSION OF MIGRATORY REGULATOR SORL1 IN THE VASCULATURE. Abstract [Details]
Toomey SM, Sharkey CT, Dooley CM, Fitzgerald DJ, and Belton OA.; (2004) The effect of a novel inhibitor of the peroxidase activity of cyclooxygenase-1 on the development of atherosclerosis. Abstract [Details]
Toomey SM, Dooley CM, Sharkey CT, Roche HM, Fitzgerald DJ, and Belton OA.; (2003) Profound resolution of atherosclerotic lesions by the 9-cis, 11-trans isomer of Conjugated Linoleic Acid. Abstract [Details]
       

Reviews

Mooney, D,McCarthy, C,Belton, O (2012) Effects of conjugated linoleic acid isomers on monocyte, macrophage and foam cell phenotype in atherosclerosis. Reviews [DOI] [Details]
                                                                                 

Research

Research Interests


 Research Links: Research in SBBS  |  Mechanisms of Disease Research in SBBS  |  Model Organisms in SBBS 
 

Atherosclerosis, the primary cause of heart disease and stroke is a complex progressive disease with multiple genetic and environmental contributions. To date there have been no defined pathways which would explain how atherosclerosis could be reversed or indeed if such a pathway exists. The implications of this are important since most patients present with pre-established lesions and the therapeutic goal would be to reverse the lesion by discriminating the pathways for regression. 


Our current programme of research investigates the fundamental mechanisms governing atherosclerosis regression. We have established a novel model of atherosclerosis regression in vivo, achieved by administration of conjugated linoleic acid (CLA)  in an apoE knockout mouse model of atherosclerosis.  

Our research has focused on the identification of distinct genes/pathways regulated by CLA that may yield further information as to how atherosclerosis can be reversed. To do this we employ an approach that involves confirmation of a phenotypic change in vivo by en face analysis and intravital microscopy. Using comprehensive "omic" approach we then construct networks associated with the altered phenotype, followed by identification of central or "hub" genes which regulate the network. Using cellular models and functional assays we validate a functional role for these hub genes in vitro examining the effect of gene deletion or over expression on, monocyte-endothelial interactions, integrin regulation, adhesion, migration and foam cell formation. We then extend this study into human patients to seek evidence for regulation of the target  genes in atherosclerotic disease progression.
 
Our other main area of research is in macrovascular complications of diabetes.  
Macrovascular complications of DM, are the primary cause of morbidity and mortality within affected patients. More than 60% of all patients with T2DM die of cardiovascular disease (CVD). Reducing the risk of or stabilizing the progression of cardiovascular disease remains a major target in people with type 2 DM. Currently we are elucidating the mechanisms through which hypoglycemic drugs alone or in combination reduces CV disease. The approach is novel where atherosclerotic plaque from patients with diabetes are challenged with hypoglycemic drugs to identify which confer an anti-inflammatory microenvironment. This work is translational in its ambition, reconciling patient data from our clinical collaborators with patient plaque RNA and cytokine analysis in response to hypoglycemic drugs, combined with RNA-seq and proteomic analysis of  human macrophages. 

 

FUNDING AGENCIES: 
Science Foundation Ireland (SFI)
Enterprise Ireland (EI)
Health Research Board (HRB)
European Federation for the Study of Diabetes (EFSD)
Wellcome Trust (Institutional Strategic Support Fund) (WT-ISSF) 

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Effect of CLA Diet Supplementation on Circulating Monocyte uptake of Fluorescent oxLDL in Atherosclerosis-prone ApoE-/- mice using Multiphoton Intravital Microscopy Imaging.
Start Date / End Date : 01-JAN-12 / 31-DEC-12
Sponsor : Health Research Board (HRB)
Title : Investigation of CLA and its effect on atherosclerosis gene expression
Start Date / End Date : 29-AUG-07 / 01-NOV-13
Sponsor : Royal Embassy of Saudi Arabia
Title : PhD Project Kawthar Alghamdi
Start Date / End Date : 03-MAR-14 / 31-MAY-18
Sponsor : University College Dublin (UCD)
Title : Clinical platform for the identification of monocyte subsets from human patients
Start Date / End Date : 03-JUN-14 / 29-AUG-14
Sponsor : European Foundation for the Study of Diabetes (EFSD)
Title : GRAMI- GLP-1 in the Regression of Atherosclerosis via Modulation of Inflammation
Start Date / End Date : 04-AUG-15 / 31-AUG-18
Sponsor : Irish Research Council (IRC)
Title : Investigation of the microRNA signature associated with regression of atherosclerosis
Start Date / End Date : 01-OCT-15 / 30-SEP-19
Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : The Wellcome Trust (WT)
Title : ISSF Mid Career Stimulus Award
Start Date / End Date : 01-JUN-17 / 30-SEP-19
Sponsor : University College Dublin (UCD)
Title : ISSF Mid Career Stimulus Award
Start Date / End Date : 01-JUN-17 / 30-SEP-19
Sponsor : University College Dublin (UCD)
Title : Development of in vivo imaging: facilitating translational research at UCD
Start Date / End Date : 01-FEB-10 / 31-JAN-11
Sponsor : Enterprise Ireland (EI)
Title : Functional Food Centre (WP6)
Start Date / End Date : 01-JUN-08 / 31-MAY-13
Sponsor : Health Research Board (HRB)
Title : ICEAGE: Investigation of CLA and its effect on atheroschlerosis gene expression
Start Date / End Date : 01-FEB-08 / 31-JAN-13
Sponsor : Health Research Board (HRB)
Title : The anti-atherogenic activity of CLA isomers
Start Date / End Date : 01-OCT-05 / 30-SEP-08
Sponsor : Enterprise Ireland (EI)
Title : Nitrosylated conjugated linoleic acids: novel treatments for existing atherosclerosis
Start Date / End Date : 01-SEP-05 / 31-AUG-06
Sponsor : Health Research Board (HRB)
Title : Cyclooxygenases in Atherosclerosis: Exploring the Cardiovascular Risk of COX-2 Inhibitors
Start Date / End Date : 01-JUL-04 / 30-JUN-07
Sponsor : Science Foundation Ireland (SFI)
Title : The genetics controlling the risk of Atherosclerosis
Start Date / End Date : 01-SEP-06 / 31-DEC-09
Sponsor : Cancer Research Ireland (CRI)
Title : Regulation of tumour-stromal interaction by cyclooxygenase-2 in gastrointestinal cancers
Start Date / End Date : 01-OCT-05 / 30-SEP-08

Recent Postgraduates

Dr. Declan Mooney (2012) 

Dr. Monica de Gaetano (2012)

Dr. Laragh Tormey (2008) 

Dr. Sarah McClelland (2007) 

Dr. Sinead Toomey (2004) 

Dr. Angela Duffy (2002)


Current Postgraduate Students

Declan Mooney, Medicine (MB BCh BAO)   -   Thesis Supervisor
Sarah Mc Clelland, Prof Cert (9)   -   Thesis Supervisor
Sean Curley, Doctor of Philosophy (PhD)   -   Secondary Supervisor
Robyn Bruen, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Stephen Fitzsimons, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Thomas Dodd, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Kawthar Saad Alghamdi, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201700   BMOL40200     Biomolecular & Biomed Science: Industry Research Project
201700   PHAR20040     Pharmacology: Pharmacology:Biomedical Scienc
201700   PHAR40030     Pharmacology: Adv Cardiovascular Pharmacol
       

Collaborators

Internal Collaborators

Prof Catherine Godson
Prof Carel Le Roux 
Prof Helen Roche 
Dr. John Crean 
Dr Fiona McGillicuddy 
Prof Donal O'Shea 
Dr Daniel Crean 
Dr Neil Docherty 


External Collaborators

Prof Aldons Jake Lusis, Dept. Human Genetics, UCLA, CA, USA

Prof. Chrostopher Glass, UCSD, USA 

Prof. Paola Patrignani, University of Chieti, italy 

Prof Peter Kelly, Mater Hospital,  Dublin

Ms. Mary Barry, St Vincent's University Hospital, Dublin
 
Prof Niall Mahon, Mater Hospital 

Prof. Matthew Griffin, NUIG, Galway 
 
 Prof David Cotter, Royal College of Surgeons in Ireland