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Researchers at UCD

researcher

Peadar Ó Gaora

Associate Professor

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166915
Email: peadar.ogaora@ucd.ie

Professional

               

Education

Year 1985 Institution: Trinity College Dublin
Qualification: BA Subject:
Year 1989 Institution: Trinity College Dublin
Qualification: PhD Subject:
Year 2001 Institution: Imperial College, London, UK
Qualification: MSc Subject:
         

Publications

     

Peer Reviewed Journals

Maguire SL, Ohéigeartaigh SS, Byrne KP, Schröder MS, O'Gaora P, Wolfe KH, Butler G (2013) 'Comparative Genome Analysis and Gene Finding in Candida Species Using CGOB'. Molecular Biology and Evolution, 30 (6):1281-1291. [DOI] Link to full text [Details]
O'Hara J, Vareslija D, McBryan J, Bane F, Tibbitts P, Byrne C, Conroy RM, Hao Y, Gaora PÓ, Hill AD, McIlroy M, Young LS (2012) 'AIB1:ERalpha Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor-Resistant Breast Cancer Cells'. Clinical cancer research : an official journal of the American Association for Cancer Research, 18 (12):3305-3315. [DOI] [Details]
Brennan EP, Morine MJ, Walsh DW, Roxburgh SA, Lindenmeyer MT, Brazil DP, Gaora PO, Roche HM, Sadlier DM, Cohen CD, Godson C, Martin F (2012) 'Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy'. Biochimica et biophysica acta, 1822 (4):589-599. [DOI] [Details]
McCartan D, Bolger JC, Fagan A, Byrne C, Hao Y, Qin L, McIlroy M, Xu J, Hill AD, Gaora Pÿ, Young LS (2012) 'Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer'. Cancer Research, 72 (1):220-229. [DOI] [Details]
Forde N, Carter F, Spencer TE, Bazer FW, Sandra O, Mansouri-Attia N, Okumu LA, McGettigan PA, Mehta JP, McBride R, O'Gaora P, Roche JF, Lonergan P; (2011) 'Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?'. Biology of Reproduction, 85 (1):144-156. [DOI] [Details]
Clemente M, Lopez-Vidriero I, O'Gaora P, Mehta JP, Forde N, Gutierrez-Adan A, Lonergan P, Rizos D; (2011) 'Transcriptome changes at the initiation of elongation in the bovine conceptus'. Biology of Reproduction, 85 (2):285-295. [DOI] [Details]
Forde N, Beltman ME, Duffy GB, Duffy P, Mehta JP, O'Gaora P, Roche JF, Lonergan P, Crowe MA.; (2011) 'Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation'. Biology of Reproduction, 84 (2):266-278. Link to full text [Details]
Krampe, B,Fagan, A,Gaora, PO,Al-Rubeai, M; (2011) 'Chemostat-Based Transcriptional Analysis of Growth Rate change and Bcl-2 Over-Expression in NS0 Cells'. Biotechnology and Bioengineering, 108 :1603-1615. [DOI] [Details]
Cederlund ML, Vendrell V, Morrissey ME, Yin J, Gaora PÓ, Smyth VA, Higgins DG, Kennedy BN.; (2011) 'mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation'. Developmental dynamics : an official publication of the American Association of Anatomists, 240 (4):745-754. [Details]
Devitt, EJ,Power, KA,Lawless, MW,Browne, JA,Gaora, PO,Gallagher, WM,Crowe, J; (2011) 'Early proteomic analysis may allow noninvasive identification of hepatitis C response to treatment with pegylated interferon alpha-2b and ribavirin'. European Journal of Gastroenterology and Hepatology, 23 :177-183. [DOI] [Details]
Power KA, Grad S, Rutges JP, Creemers LB, van Rijen MH, O'Gaora P, Wall JG, Alini M, Pandit A, Gallagher WM (2011) 'Identification of cell surface-specific markers to target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with age and degeneration'. Arthritis Rheumatology, 63 (12):3876-3886. [DOI] [Details]
Young LS, McIlroy M, McCartan D, Early S, O Gaora P, Pennington S, Hill AD, ; (2010) 'Interaction of developmental transcription factor HOX11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer'. Cancer Research, 70 (4):1585-1594. [DOI] [Details]
Fitzpatrick DA, O'Gaora P, Byrne KP, Butler G.; (2010) 'Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser'. BMC Genomics, 11 :290-303. [DOI] [Details]
Morine, M.J., McMonagle, J., Toomey, S., Reynolds, C.M., Moloney, A.P., Gormley, I.C., O'Gaora, P. and Roche, H.M. (2010) 'Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome'. BMC Bioinformatics, 11 (1). [DOI] [Details]
Fitzpatrick DA, O'Gaora P, Byrne KP, Butler G; (2010) 'Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser'. BMC Genomics, 11 :290. [DOI] [Details]
Forde N, Beltman ME, Duffy GB, Duffy P, Mehta JP, O'Gaora P, Roche JF, Lonergan P, Crowe MA; (2010) 'Changes in the Endometrial Transcriptome During the Bovine Estrous Cycle: Effect of Low Circulating Progesterone and Consequences for Conceptus Elongation'. Biology of Reproduction, . [DOI] [Details]
McCarthy, C,O'Gaora, P,James, WG,McClelland, S,Fitzgerald, DJ,Belton, O,de Gaetano, M; (2010) 'SorLA modulates atheroprotective properties of CLA by regulating monocyte migration'. Atherosclerosis, 213 :400-407. [DOI] [Details]
Jennings P, Aydin S, Bennett J, McBride R, Weiland C, Tuite N, Gruber LN, Perco P, Gaora PO, Ellinger-Ziegelbauer H, Ahr HJ, Kooten CV, Daha MR, Prieto P, Ryan MP, Pfaller W, McMorrow T; (2009) 'Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to cyclosporine a exposure and medium exhaustion'. Toxicology in Vitro, 23 (3):486-499. [DOI] [Details]
Jennings P, Aydin S, Bennett J, McBride R, Weiland C, Tuite N, Gruber LN, Perco P, Gaora PO, Ellinger-Ziegelbauer H, Ahr HJ, Kooten CV, Daha MR, Prieto P, Ryan MP, Pfaller W, McMorrow T; (2009) 'Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion'. Toxicology in Vitro, 23 (3):486-499. [Details]
N Forde, F Carter, T Fair, MA Crowe, ACO Evans, TE Spencer, FW Bazer, R McBride, MP Boland, P O'Gaora, P Lonergan, JF Roche; (2009) 'Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus develoment in cattle'. Biology of Reproduction, 81 (4):784-794. [Details]
Power, K. A.,McRedmond, J. P.,de Stefani, A.,Gallagher, W. M.,Gaora, P. O.; (2009) 'High-throughput proteomics detection of novel splice isoforms in human platelets'. PLoS ONE, 4 (3):e5001. Available Online [Details]
Power KA, McRedmond JP, de Stefani A, Gallagher WM, Ó Gaora P; (2009) 'High-throughput proteomics detection of novel splice isoforms in human platelets'. PLoS ONE, 4 (3). [DOI] [Details]
Mullane, NR,Ryan, M,Iversen, C,Murphy, M,O'Gaora, P,Quinn, T,Whyte, P,Wall, PG,Fanning, S; (2008) 'Development of multiple-locus variable-number tandem-repeat analysis for the molecular subtyping of Enterobacter sakazakii'. Applied and Environmental Microbiology, 74 (NA):1223-1231. [DOI] [Details]
Mullane, N., O'Gaora, P., Nally, J. E., Iversen, C., Whyte, P., Wall, P. G., Fanning, S., ; (2008) 'Molecular analysis of the Enterobacter sakazakii O-antigen gene locus'. Applied and Environmental Microbiology, 74 (12):3783-3794. [Details]
Drudy D, Quinn T, O'Mahony R, Kyne L, O'Gaora P, Fanning S.; (2006) 'High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile'. Journal of Antimicrobial Chemotherapy, 58 (6):1264-1267. [Details]
Bishop AL, Baker S, Jenks S, Fookes M, Ó Gaora P, Pickard D, Anjum M, Farrar J, Hien TT, Ivens A, Dougan G.; (2005) 'Analysis of the hypervariable region of the Salmonella enterica genome associated with tRNA(leuX)'. Journal of Bacteriology, 187 (7):2469-2482. [Details]
Cahill RJ, Tan S, Dougan G, O'Gaora P, Pickard D, Kennea N, Sullivan MH, Feldman RG, Edwards AD; (2005) 'Universal DNA primers amplify bacterial DNA from human fetal membranes and link Fusobacterium nucleatum with prolonged preterm membrane rupture'. Molecular Human Reproduction, 11 (10):761-766. [DOI] [Details]
Dougan G, Pickard D, Wain J, Baker S, Line A, Chohan S, Fookes M, Barron A, Gaora PO, Chabalgoity JA, Thanky N, Scholes C, Thomson N, Quail M, Parkhill J, ; (2003) 'Composition, acquisition, and distribution of the Vi exopolysaccharide-encoding Salmonella enterica pathogenicity island SPI-7'. Journal of Bacteriology, 185 (17):5055-5065. [Details]
Wain J, Diem Nga LT, Kidgell C, James K, Fortune S, Song Diep T, Ali T, O Gaora P, Parry C, Parkhill J, Farrar J, White NJ, Dougan G; (2003) 'Molecular analysis of incHI1 antimicrobial resistance plasmids from Salmonella serovar Typhi strains associated with typhoid fever'. Antimicrobial Agents and Chemotherapy, 47 (9):2732-2739. [Details]
Dougan G, Kidgell C, Pickard D, Wain J, James K, Diem Nga LT, Diep TS, Levine MM, O'Gaora P, Prentice MB, Parkhill J, Day N, Farrar J, ; (2002) 'Characterisation and distribution of a cryptic Salmonella typhi plasmid pHCM2'. Plasmid, 47 (3):159-171. [Details]
Wain J, Dougan G, Haque A, Pickard D, Frankel G, O'Goara P, ; (2001) 'The Escherichia coli gene pool'. Current Opinion in Microbiology, 4 (1):90-94. [Details]
Young DB, Stewart GR, Snewin VA, Walzl G, Hussell T, Tormay P, O'Gaora P, Goyal M, Betts J, Brown IN, ; (2001) 'Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection'. Nature Medicine, 7 (6):732-737. [DOI] [Details]
Young DB, Marshall BG, Wangoo A, O'Gaora P, Cook HT, Shaw RJ, ; (2001) 'Enhanced antimycobacterial response to recombinant Mycobacterium bovis BCG expressing latency-associated peptide'. Infection and Immunity, 69 (11):6676-6682. [DOI] [Details]
Barrell BG, Parkhill J, Dougan G, James KD, Thomson NR, Pickard D, Wain J, Churcher C, Mungall KL, Bentley SD, Holden MT, Sebaihia M, Baker S, Basham D, Brooks K, Chillingworth T, Connerton P, Cronin A, Davis P, Davies RM, Dowd L, White N, Farrar J, Feltwell T, Hamlin N, Haque A, Hien TT, Holroyd S, Jagels K, Krogh A, Larsen TS, Leather S, Moule S, O'Gaora P, Parry C, Quail M, Rutherford K, Simmonds M, Skelton J, Stevens K, Whitehead S, ; (2001) 'Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18'. Nature, 413 (6858):848-852. [DOI] [Details]
Levin M, Kampmann B, Gaora PO, Snewin VA, Gares MP, Young DB, ; (2000) 'Evaluation of human antimycobacterial immunity using recombinant reporter mycobacteria'. Journal of Infectious Diseases, 182 (3):895-901. [DOI] [Details]
Young DB, Snewin VA, Gares MP, Gaora PO, Hasan Z, Brown IN, ; (1999) 'Assessment of immunity to mycobacterial infection with luciferase reporter constructs'. Infection and Immunity, 67 (9):4586-4593. [Details]
So M, Arvidson CG, Kirkpatrick R, Witkamp MT, Larson JA, Schipper CA, Waldbeser LS, O'Gaora P, Cooper M, ; (1999) 'Neisseria gonorrhoeae mutants altered in toxicity to human fallopian tubes and molecular characterization of the genetic locus involved'. Infection and Immunity, 67 (2):643-652. [Details]
Lewis DJ, Hayward CM, O'Gaora P, Young DB, Griffin GE, Thole J, Hirst TR, Castello-Branco LR, ; (1999) 'Construction and murine immunogenicity of recombinant Bacille Calmette Guérin vaccines expressing the B subunit of Escherichia coli heat labile enterotoxin'. Vaccine, 17 (9-10):1272-1281. [Details]
Gaora PO, ; (1998) 'Expression of genes in mycobacteria'. Methods in Molecular Biology, 101 :261-273. [DOI] [Details]
Herrmann JL, O'Gaora P, Gallagher A, Thole JE, Young DB; (1996) 'Bacterial glycoproteins: a link between glycosylation and proteolytic cleavage of a 19 kDa antigen from Mycobacterium tuberculosis'. Embo Journal, 15 (14):3547-3554. [Details]
So M, Stojiljkovic I, Hwa V, de Saint Martin L, O'Gaora P, Nassif X, Heffron F, ; (1995) 'The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence'. Molecular Microbiology, 15 (3):531-541. [Details]
So M, Nassif X, Beretti JL, Lowy J, Stenberg P, O'Gaora P, Pfeifer J, Normark S, ; (1994) 'Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells'. Proceedings of the National Academy of Sciences of the United States of America, 91 (9):3769-3773. [Details]
Nassif X, Lowy J, Stenberg P, O'Gaora P, Ganji A, So M; (1993) 'Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells'. Molecular Microbiology, 8 (4):719-725. [Details]
Johnson K, Charles I, Dougan G, Pickard D, O'Gaora P, Costa G, Ali T, Miller I, Hormaeche C; (1991) 'The role of a stress-response protein in Salmonella typhimurium virulence'. Molecular Microbiology, 5 (2):401-407. [Details]
Johnson KS, Charles IG, Dougan G, Miller IA, Pickard D, O'Goara P, Costa G, Ali T, Hormaeche CE; (1990) 'The role of a stress-response protein in bacterial virulence'. Research in Microbiology, 141 (7-8):823-825. [Details]
O'Gaora P, Roberts M, Bowe F, Hormaeche C, Demarco de Hormaeche R, Cafferkey M, Tite J, Dougan G; (1990) 'Yersinia enterocolitica aroA mutants as carriers of the B subunit of the Escherichia coli heat-labile enterotoxin to the murine immune system'. Microbial pathogenesis, 9 (2):105-116. [Details]
O'Gaora P, Maskel D, Coleman D, Cafferkey M, Dougan G; (1989) 'Cloning and characterisation of the serC and aroA genes of Yersinia enterocolitica, and construction of an aroA mutant'. Gene, 84 (1):23-30. [Details]
Bowe F, O'Gaora P, Maskell D, Cafferkey M, Dougan G; (1989) 'Virulence, persistence, and immunogenicity of Yersinia enterocolitica O:8 aroA mutants'. Infection and Immunity, 57 (10):3234-3236. [Details]
 

Conference Publications

Drudy, D., Quinn, T., O'Mahony, R., Kyne, L., O'Gaora, P. & Fanning, S.; Fluoroquinolone Resistance in Toxin A negative Toxin B positive Clostridium difficile associated with a novel mutation in gyrB Clostpath-2006 Nottingham United Kingdom, [Details]
Forde, N., Carter, F., Fair, T., Crowe, M., Evans, A.C.O., Spencer, T., Bazer, F.,O'Gaora, P., Mc Bride, R., Boland, M., Lonergan, P., Roche, J.; (2008) Effect of pregnancy and progesterone on gene expression in the uterine endometrium of cattle 41st Annual Meeting of the Society for the Study of Reproduction Hawaii, USA, , pp.67-68 [Details]
Mullane, N., Ryan, M., Iversen, C., Murphy, M., O¿Gaora, P., Quinn, T., Whyte, P., Wall., P., Fanning, S; (2007) Development of Multiple-Locus Variable Number Tandem Repeat Analysis for the Molecular Subtyping of Enterobacter sakazakii International Association for Food Protection’s Third European Symposium on Food Safety, Rome Italy [Details]
                                                                                                                 

Research

Research Interests

 

Recent Postgraduates

Finbarr Tarrant
PhD awarded 2015
Principal Supervisor

Yuan Hao
PhD awarded 2012
Principal Supervisor

Melissa Morine
PhD awarded 2011
Co-supervisor

Rachael McBride
PhD awarded 2010
Principal supervisor

Karen Power
PhD awarded 2008
Co-supervisor