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Antoinette Perry

Lecturer

School of Biomolecular & Biomedical Science
UCD Conway Institute of Biomolecular and Biomedical Science Research

Tel: +353 1 7166751
Email: antoinette.perry@ucd.ie

Biography

12 years experience in cancer pathogenesis and epigenetics. Recently appointed Lecturer in Cancer Biology at University College Dublin, with a research team of three.

RESEARCH POSITIONS
2015 -                  Lecturer, School of Biomedical & Biomolecular Sciences, University College Dublin

2012 - 2015         Senior Research Fellow, School of Medicine, Trinity College Dublin

2009 - 2012         Research Fellow, School of Medicine, Trinity College Dublin     

2006 - 2009         Postdoctoral Scientist, School of Medicine, Trinity College Dublin

2006                    3-month Internship, National Cancer Institute, NIH, Bethesda

2001 - 2002         Research assistant, School of Genetics and Microbiology, Trinity College


EDUCATION

2007 Ph.D., Trinity College Dublin

2006 Postgraduate Diploma in Statistics, Trinity College Dublin

2001 B.A. (Mod. Human Genetics), Trinity College Dublin

Professional

Honours and Awards

Year: 2008.
Title: 1st Prize, Poster Presentations
Year: 2006.
Title: 1st Prize, Oral Presentations
Year: 2010.
Title: 1st Prize, Oral Presentations
Year: 2011.
Title: 1st Prize, ICS Celebration of Research Poster Presentations

Associations

Association: Irish Association of Cancer Research , Function/Role: Member
Association: European Association of Cancer Research, Function/Role: Member
       

Committees

Committee : National Kidney Disease Biobank Steering Committee
Committee : Irish Association of Cancer Research
Committee : Prostate Cancer Research Group
             

Publications

     

Peer Reviewed Journals

Foley, R.W., Gorman, L.V., Sharifi, N., Lundon, D.J., Murphy, K., Moore, H., Tuzova, A., Perry, A., Murphy, T.B. and Watson, R.W.G. (2015) 'Improving Multivariable Prostate Cancer Risk Assessment Using The Prostate Health Index'. BJU international, . [DOI] [Details]
Perry AS, Baird AM;Gray SG (2015) 'Epigenetic Methodologies for the Study of Celiac Disease'. Methods in molecular biology (Clifton, N.J.), 1326 :131-158. [DOI] [Details]
Bolton EM, Tuzova AV;Walsh AL;Lynch T;Perry AS (2014) 'Noncoding RNAs in prostate cancer: the long and the short of it'. Clinical cancer research : an official journal of the American Association for Cancer Research, 20 (1):35-43. [DOI] [Details]
Walsh AL, Tuzova AV;Bolton EM;Lynch TH;Perry AS (2014) 'Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'?'. Trends in Molecular Medicine, 20 (8):428-436. [DOI] [Details]
Vajda A, Marignol L;Barrett C;Madden SF;Lynch TH;Hollywood D;Perry AS (2013) 'Gene expression analysis in prostate cancer: the importance of the endogenous control'. Prostate, 73 (4):382-390. [DOI] [Details]
O'Rourke CJ, Murphy TM;Hollywood D;Perry AS (2013) 'Mining methylome databases'. Trends in genetics : TIG, 29 (2):63-65. [DOI] [Details]
O'Rourke CJ, Knabben V;Bolton E;Moran D;Lynch T;Hollywood D;Perry AS (2013) 'Manipulating the epigenome for the treatment of urological malignancies'. Pharmacology & therapeutics, 138 (2):185-196. [DOI] [Details]
Perry AS, O'Hurley G;Raheem OA;Brennan K;Wong S;O'Grady A;Kennedy AM;Marignol L;Murphy TM;Sullivan L;Barrett C;Loftus B;Thornhill J;Hewitt SM;Lawler M;Kay E;Lynch T;Hollywood D (2013) 'Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer'. International Journal of Cancer, 132 (8):1771-1780. [DOI] [Details]
O'Kelly F, Marignol L;Meunier A;Lynch TH;Perry AS;Hollywood D (2012) 'MicroRNAs as putative mediators of treatment response in prostate cancer'. Nature reviews. Urology, 9 (7):397-407. [DOI] [Details]
Gray SG, Baird AM;O'Kelly F;Nikolaidis G;Almgren M;Meunier A;Dockry E;Hollywood D;Ekstr¿¿m TJ;Perry AS;O'Byrne KJ (2012) 'Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor'. International Journal of Molecular Medicine, 30 (6):1505-1511. [DOI] [Details]
Sullivan L, Murphy TM;Barrett C;Loftus B;Thornhill J;Lawler M;Hollywood D;Lynch T;Perry AS (2012) 'IGFBP7 promoter methylation and gene expression analysis in prostate cancer'. Urology, 188 (4):1354-1360. [DOI] [Details]
Murphy TM, Sullivan L, Lane C, O'Connor L, Barrett C, Hollywood D, Lynch T, Lawler M, Perry AS; (2011) 'In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer'. Prostate, 71 (1):1-17. [DOI] [Details]
Forde JC, Perry AS;Brennan K;Martin LM;Lawler MP;Lynch TH;Hollywood D;Marignol L (2012) 'Docetaxel maintains its cytotoxic activity under hypoxic conditions in prostate cancer cells'. Urologic oncology, 30 (6):912-919. [DOI] [Details]
O'Hurley G, Perry AS;O'Grady A;Loftus B;Smyth P;O'Leary JJ;Sheils O;Fitzpatrick JM;Hewitt SM;Lawler M;Kay EW (2011) 'The role of secreted frizzled-related protein 2 expression in prostate cancer'. Histopathology, 59 (6):1240-1248. [DOI] [Details]
Prencipe M, McGoldrick A, Perry AS, O'Grady A, Phelan S, McGrogan B, Fitzpatrick P, Watson JA, Furlong F, Brennan DJ, Lawler M, Kay E, McCann A; (2010) 'MAD2 downregulation in hypoxia is independent of promoter hypermethylation'. Cell, 9 (14):2856-2865. [Details]
Magee AM, Aspinall S;Rice DW;Cusack BP;S¿¿mon M;Perry AS;Stefanovi¿¿ S;Milbourne D;Barth S;Palmer JD;Gray JC;Kavanagh TA;Wolfe KH (2010) 'Localized hypermutation and associated gene losses in legume chloroplast genomes'. Genome Research, 20 (12):1700-1710. [DOI] [Details]
Perry AS, Watson RW, Lawler M, Hollywood D (2010) 'The epigenome as a therapeutic target in prostate cancer'. Nature Reviews Urology, 7 (12):668-680. [DOI] [Details]
Foley R, Marignol L;Thomas AZ;Cullen IM;Perry AS;Tewari P;O'Grady A;Kay E;Dunne B;Loftus B;Watson WR;Fitzpatrick JM;Woodson K;Lehman T;Hollywood D;Lynch TH;Lawler M (2009) 'The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers'. Cancer biology & therapy, 8 (2):118-124. [Details]
Murphy TM, Perry AS, Lawler M; (2008) 'The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer'. Journal of Cancer, 15 (1):11-25. [DOI] [Details]
Perry AS, Liyanage H;Lawler M;Woodson K (2007) 'Discovery of DNA hypermethylation using a DHPLC screening strategy'. Epigenetics, 2 (1):43-49. [Details]
Perry AS, Loftus B;Moroose R;Lynch TH;Hollywood D;Watson RW;Woodson K;Lawler M (2007) 'In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer'. British Journal of Cancer, 96 (10):1587-1594. [DOI] [Details]
Perry AS, Foley R;Woodson K;Lawler M (2006) 'The emerging roles of DNA methylation in the clinical management of prostate cancer'. Endocrine-Related Cancer, 13 (2):357-377. [DOI] [Details]
Perry AS, Brennan S;Murphy DJ;Kavanagh TA;Wolfe KH (2002) 'Evolutionary re-organisation of a large operon in adzuki bean chloroplast DNA caused by inverted repeat movement'. DNA research : an international journal for rapid publication of reports on genes and genomes, 9 (5):157-162. [Details]
Perry AS, Wolfe KH (2002) 'Nucleotide substitution rates in legume chloroplast DNA depend on the presence of the inverted repeat'. Journal of Molecular Evolution, 55 (5):501-508. [DOI] [Details]
 

Conference Publications

D'Arcy, F., Foley, R., Perry, A., Marignol, L., Lawler, M., Gaffney, E., Watson, R. G. W., Fitzpatrick, J. M., Lynch, T. H., ; (2008) European Urology Supplements No evidence of XMRV in irish prostate cancer patients with the R462q mutation , pp.271-271 [Details]
                       

Abstract

D'Arcy, F,Foley, R,Perry, A,Marignol, L,Gaffney, E,Dunne, B,Lawler, MP,Watson, RWG,Fitzpatrick, JM,Lynch, TH (2007) RNASEL and its role in Irish prostate cancer patients. Abstract [Details]
D'Arcy, F,Foley, R,Perry, A,Marignol, L,Lawler, M,Gaffney, E,Watson, RGW,Fitzpatrick, JM,Lynch, TH (2008) No evidence of XMRV in irish prostate cancer patients with the R462q mutation. Abstract [Details]
                                                               

Research

 

Research Projects

Sponsor : Irish Cancer Society (ICS)
Title : Deciphering Epigenetic Regulators of Enhancers in Agrressive Prostate Cancer
Start Date / End Date : 01-OCT-15 / 30-SEP-19
Sponsor : Royal Irish Academy (RIA)
Title : RIA / RS International Cost Share Agreement
Start Date / End Date : 09-OCT-15 / 28-FEB-17

Recent Postgraduates

In my short career as a principal investigator, I have successfully supervised
- 2 PhD students to completion (research areas: hypermethylation of apoptotic genes in prostate cancer; epigenetic roadmap of prostate cancer),
- 2 MD students (research areas: non-coding RNAs in prostate cancer) and
- 1 research MSc student. 
 

Teaching

 

Modules Coordinated

201500   BMOL40050     Biomolecular & Biomed Science: Adv Pharmacology of Cancer
201500   BIOC40110     Biochemistry: Biomedical Diagnostics