Navigation

Researchers at UCD

researcher

Breandán Kennedy

Conway Fellow

Conway Institute of Biomolecular & Biomedical Research

Tel: 7166740
Email:

Biography

¿Principal Investigator¿

  • 2013-present: Marie Curie Fellow & Co-Ordinator of IAPP 3D-NET Industry-Academia Consortium. 
  • 2011-2015, UCD. Head of Pharmacology.
  • 2007-present; UCD: Senior Lecturer in School of Biomolecular & Biomedical Sciences.
  • 2003-present: Director of Ocular Pharmacology & Genetics Research Group, UCD. 
  • 2003-present: Director of UCD Zebrafish Facility. 
  • 2003-present: UCD Conway Institute Fellow. 
  • 2003-2007; UCD: College Lecturer in School of Biomolecular & Biomedical Sciences.  


¿Postdoctoral Fellow¿
   
2000-2003:  UNIVERSITY OF WASHINGTON, SEATTLE, USA: Senior fellow in Prof. James Hurley¿s lab.  Projects analysed eye development using mutant zebrafish and investigated cone photoreceptor function using transgenic zebrafish. 

1999-2000, UNIVERSITY OF NOTRE DAME, INDIANA, USA: Postdoctoral fellow in Prof. David Hyde¿s lab.  Projects include characterization of promoters directing rod photoreceptor-specific expression in transgenic zebrafish. 

¿Graduate Student¿
1994-1998, W. ALTON JONES CELL SCIENCE CENTER, NEW YORK, USA: Ph.D. thesis research under supervision of Dr. John Crabb.  Studies investigated the regulation of CRALBP transcription, targeted disruption of the mouse CRALBP gene, and identification and analysis of a mutation in CRALBP segregating with retinitis pigmentosa. 


Research Links:  SBBS Research  |  Mechanisms of Disease Research in SBBS  |  Model Organisms Research in SBBS  |  3D-NET Consortium 

Professional

Honours and Awards

Year: 2012.
Title: Geraldine Duggan Young Investigator Award
Year: 2013.
Title: Runner-up UCD Images of Research; Finding Colour in Black & White
Year: 2013.
Title: UCD Conway Innovation Festival Award Best ¿therapies¿ Poster
Year: 2014.
Title: Iona Pratt Medal
Year: 2014.
Title: Biochemical Society Irish Area Section Meeting Best Poster
Year: 2014.
Title: UCD Pharmacology and Roddy Monks Medals
Year: 2014.
Title: SFI TIDA Get Started Technology Venture Programme Joint Winner
Year: 2014.
Title: Geraldine Duggan Young Investigator Award
Year: 2015.
Title: National Eye Institute Travel Award
Year: 2015.
Title: 18th Vitamin D Workshop Best Poster
Year: 2015.
Title: UCD Pharmacology and Roddy Monks Medals
Year: 2015.
Title: British Pharmacological Society Undergraduate Medal
Year: 2015.
Title: UCD Conway Research Medal
Year: 2015.
Title: British Pharmacological Society Ambassador
Year: 2015.
Title: Phenotype-Based Discovery of Novel Colorectal Cancer Drugs
Year: 1993.
Title: Ph.D. scholarship from W. Alton Jones Cell Science Center
Year: 1999.
Title: Postdoctoral fellowship from the Keck Center for Transgene Research
Year: 2000.
Title: Travel award to 4th International Zebrafish Development & Genetics Meeting, CSH, NY
Year: 2000.
Title: Postdoctoral fellowship from Howard Hughes Medical Institute
Year: 2004.
Title: Presidents Research Award
Year: 2004.
Title: National Eye Institute ¿Young Investigator Travel Award¿ to XIth International Symposium on Retinal Degeneration (RD2004), Perth, Australia

Associations

Association: Association for Research in Vision and Ophthalmology, Function/Role: *
Association: Biochemical Society, Function/Role: Member
Association: Association for Research in Vision and Ophthalmology, Function/Role: Regular Member
Association: British Pharmacological Society, Function/Role: Member and Ambassador

Patents

Patent WO Patent WO 2012/095836 A1 : Anti-angiogenic compound
Patent WO Patent WO 2014/012889 A1 : Anti-angiogenic compounds.
Patent US Patent US 8,916,586 B2 : Anti-angiogenic compound.
Patent US 2015/0218100 A1 : Anti-angiogenic compounds.
Patent WO 2015/107122 A1 : Anti-angiogenic compounds
Patent US Patent 8,916,586 : Anti-angiogenic compound

Disclosures

Anti angiogenic Compounds. Inventor(s):Breandan Kennedy, Submitted: 14-JAN-11
 

Conference Contributions

2003, Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E.; (2003) Rx3 is required for eye development. . [Poster Presentation], 3rd European Conference on Zebrafish & Medaka Development and Genetics, Paris , 11-JUN-03 - 14-JUN-03.
Kennedy, BN; (2004) Fishing for determinants of cone photoreceptor function. [Invited Oral Presentation], Centre for Integrative Biology Symposium, Dublin , 19-FEB-04 - 19-FEB-04.
1Kennedy, Breandan; 1Collery, Ross; 1Cederlund, Maria; 2Hurley, James and 2Brockerhoff, Susan.; (2004) DETERMINANTS OF CONE PHOTORECEPTOR FUNCTION AND SURVIVAL . [Invited Oral Presentation], XIth International Conference on Retinal Degeneration, Perth, Australia , 23-AUG-04 - 28-AUG-04.
Kennedy, Breandan N; (2004) Zebrafish:A Model Organism for Retinal Research . [Invited Oral Presentation], The Fighting Blindness Science Forum, Dublin , 23-SEP-04 - 24-SEP-04.
Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E.; (2002) Visual and Photoneuroendocrine System Development in eym and TG(TaCP-EGFP). [Invited Oral Presentation], 5th International Conference on Zebrafish Development and Genetics, Madison, WI , 12-JUN-02 - 16-JUN-02.

Committees

Committee : Breast Cancer Campaign UK.
Committee : Medical Research Council, UK.
Committee : M.J. Murdock Charitable Trust Scientific Research Grant Program (USA)
Committee : Auckland Medical Research Foundation (New Zealand)
Committee : 2014; U.S.-Israel Binational Science Foundation
Committee : 2015, Uitzicht Project Grant, Netherlands
Committee : European Commission H2020 Expert Evaluator PHC14
Committee : MRC Grant Reviewer 2010
Committee : MRC Grant Reviewer 2011
Committee : DCCR Ophthalmology Group

Employment

Employer: University College Dublin.
Position: College Lecturer
Employer: University of Washington, Seattle
Position: Senior Fellow
Employer: University of Notre Dame, Indiana
Position: Postdoctoral Fellow
Employer: University College Dublin
Position: Ph.D

Education

Year 1999 Institution: University College Dublin
Qualification: PhD Subject:
Year 1998 Institution: University College Dublin
Qualification: PhD Subject: --none--
Year 1993 Institution: University College Dublin
Qualification: BSc Subject:
   

Outreach Activities

2012.  Science Week School Talk & Presentation to 5/6th Class at Dominican College, Muckross Park, Donnybrook, Dublin 4.

Journals Edited

Bmc Developmental Biology: Reviewer.
 

Publications

 

Book Chapters

Collery, R.F., Cederlund, M.L., Smyth, V.A. and Kennedy, B.N.; (2006) 'Applying Transgenic Zebrafish Technology To Study The Retina' In: Hollyfield J.G., Anderson, R.E., and La Vail M.M (eds). Advances in Experimental Medicine and Biology. New York: Springer. , pp.201-207 [Details]
Kennedy, B.N., Saari, J.C., and Crabb, J.W.; (1999) 'CRALBP and inherited retinal degeneration' In: Hollyfield J.G., Anderson, R.E., and La Vail (eds). Retinal Degenerative Disease and Experimental Therapy (Plenum, NY). , pp.43-53 [Details]
 

Peer Reviewed Journals

Conor Daly, Jun Yin, Breandán N Kennedy (2016) 'Histone Deacetylase: Therapeutic Targets in Retinal Degeneration'. Advances in experimental medicine and biology, :455-461. [Details]
Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen JE, Conroy J, Regan R, Kenny E, Cormican P, Morris DW, Tormey P, Chróinín MN, Kennedy BN, Lynch S, Green A, Ennis S (2011) 'First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype'. Human Mutation, 32 (12):1417-1426. [DOI] [Details]
Reynolds, AL,Blacque, OE,Kennedy, BN (2012) 'The Genetics of Outer Segment Morphogenesis in Zebrafish'. Advances in experimental medicine and biology, 723 :431-441. [DOI] [Details]
Yin, J,Shine, L,Raycroft, F,Deeti, S,Reynolds, A,Ackerman, KM,Glaviano, A,O'Farrell, S,O'Leary, O,Kilty, C,Kennedy, C,McLoughlin, S,Rice, M,Russell, E,Higgins, DG,Hyde, DR,Kennedy, BN (2012) 'Inhibition of the Pim1 Oncogene Results in Diminished Visual Function'. PLoS ONE, 7 . [DOI] [Details]
Yin J, Morrissey ME, Shine L, Kennedy C, Higgins DG, Kennedy BN (2014) 'Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis'. Genomics, 15 (1). [DOI] [Details]
Casey, J.P. and McGettigan, P.A. and Healy, F. and Hogg, C. and Reynolds, A. and Kennedy, B.N. and Ennis, S. and Slattery, D. and Lynch, S.A. (2015) 'Unexpected genetic heterogeneity for primary ciliary dyskinesia in the Irish Traveller population'. European Journal of Human Genetics, 23 (2):210-217. Available Online [DOI] [Details]
Sasore T, Kennedy B. (2014) 'Deciphering Combinations of PI3K/AKT/mTOR Pathway Drugs Augmenting Anti-Angiogenic Efficacy In Vivo'. PLoS ONE, . [Details]
Reynolds AL, Kent D, Kennedy BN. (2014) 'Current and emerging therapies for ocular neovascularisation'. Advances in experimental medicine and biology, 2014;801: :797-804. [Details]
Sasore T, Reynolds AL, Kennedy BN. (2014) 'Targeting the PI3K/Akt/mTOR pathway in ocular neovascularization'. Advances in experimental medicine and biology, 801 :805-811. [Details]
Shine L, Kilty C, Gross J, Kennedy B. (2014) 'Vacuolar ATPases and their role in vision'. Advances in experimental medicine and biology, 801 :97-103. [Details]
Casey, J; McGettigan, P; Healy, F; Hogg, C; Reynolds, A; Kennedy, B; Ennis, S; Slattery, D; Lynch, SA. (2013) 'Unexpected genetic heterogeneity for primary ciliary dyskinesia in the Irish Traveller population'. European Journal of Human Genetics, . Available Online [DOI] Link to full text [Details]
Deeti S, O'Farrell S, Kennedy BN. (2013) 'Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response'. Journal of Pharmacol Toxicol Methods, 30 (69). [Details]
Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN. (2011) 'Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants'. BMC Developmental Biology, 11 (71). [Details]
Collery RF, Cederlund ML, Kennedy BN (2013) 'Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology'. Experimental Eye Research, . [DOI] [Details]
Fichtnera I, Cinatl jr. J, Michaelis M, Sanders LC, Hilger R, Kennedy BN, Reynolds AL, Hackenberg F, Lally G, Quinn SJ, McRae I and Tacke M (2012) 'In Vitro and In Vivo Investigations into the Carbene Silver Acetate'. Letters in Drug Design & Discovery, . [Details]
Morrissey ME, Shelton S, Brockerhoff SE, Hurley JB, Kennedy BN; (2011) 'PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors'. BMC Developmental Biology, 11 . [DOI] [Details]
Cederlund ML, Morrissey ME, Baden T, Scholz D, Vendrell V, Lagnado L, Connaughton VP, Kennedy BN.; (2011) 'Zebrafish Tg(7.2mab21l2:EGFP)ucd2 transgenics reveal a unique population of retinal amacrine cells'. Investigative Ophtalmology and Visual Science, 52 (3):1613-1621. [Details]
Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen JE, Conroy J, Regan R, Kenny E, Cormican P, Morris DW, Tormey P, Ni Chroinin M, Kennedy BN, Lynch S, Green A, Ennis S.; (2011) 'First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: A new dimension to the STRA6 phenotype'. Human Mutation, 32 (12):1417-1426. [Details]
Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN. (2011) 'Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants'. BMC Developmental Biology, 11 . [DOI] [Details]
Cederlund ML, Vendrell V, Morrissey ME, Yin J, Gaora PÓ, Smyth VA, Higgins DG, Kennedy BN.; (2011) 'mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation'. Developmental dynamics : an official publication of the American Association of Anatomists, 240 (4):745-754. [Details]
Alvarez Y, Chen K, Reynolds AL, Waghorne N, O'Connor JJ, Kennedy BN, ; (2010) 'Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy'. Disease models & mechanisms, 3 (3-4):236-245. [DOI] [Details]
Atzei, P,Yang, F,Collery, R,Kennedy, BN,Moynagh, PN; (2010) 'Characterisation of expression patterns and functional role of Cactin in early zebrafish development'. Gene, 10 :199-206. [DOI] [Details]
Higgins DG, Yin J, McLoughlin S, Jeffery IB, Glaviano A, Kennedy B, ; (2010) 'Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data'. Genomics, 11 . [DOI] [Details]
Yin, J,McLoughlin, S,Jeffery, IB,Glaviano, A,Kennedy, B,Higgins, DG; (2010) 'Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data'. Genomics, 11 . [DOI] [Details]
Atzei P, Yang F, Collery R, Kennedy BN, Moynagh PN; (2010) 'Characterisation of expression patterns and functional role of Cactin in early zebrafish development'. Gene expression patterns : GEP, 10 (4-5):199-206. [DOI] [Details]
Kennedy BN, Collery RF, ; (2010) 'Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish'. Advances in Experimental Medical Biology, 664 :55-61. [DOI] [Details]
Malicki, J and Kennedy B.N; (2009) 'What drives cell morphogenesis - a look inside the vertebrate photoreceptor. '. Developmental dynamics : an official publication of the American Association of Anatomists, . [Details]
Kennedy BN, Alvarez Y, Astudillo O, Jensen L, Reynolds AL, Waghorne N, Brazil DP, Cao Y, O'Connor JJ, ; (2009) 'Selective inhibition of retinal angiogenesis by targeting PI3 kinase'. PLoS ONE, 4 (11). [DOI] [Details]
Alvarez, Y,Astudillo, O,Jensen, L,Reynolds, AL,Waghorne, N,Brazil, DP,Cao, YH,O'Connor, JJ,Kennedy, BN; (2009) 'Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase'. PLoS ONE, 4 (11):1-10. [DOI] [Details]
Coss A, Tosetto M, Fox EJ, Sapetto-Rebow B, Gorman S, Kennedy BN, Lloyd AT, Hyland JM, O'Donoghue DP, Sheahan K, Leahy DT, Mulcahy HE, O'Sullivan JN ; (2009) 'Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis'. Cancer Letters, 276 :228-238. [Details]
Smyth VA, Di Lorenzo D, Kennedy BN. ; (2008) 'A novel, evolutionary conserved enhancer of cone photoreceptor-specific expression'. JOURNAL OF BIOLOGICAL CHEMISTRY, . [Details]
Kennedy BN, Collery R, McLoughlin S, Vendrell V, Finnegan J, Crabb JW, Saari JC, ; (2008) 'DUPLICATION AND DIVERGENCE OF ZEBRAFISH CRALBP GENES UNCOVERS A NOVEL ROLE FOR RPE- AND MUELLER-CRALBP IN CONE VISION'. Invest Ophthalmol Vis Sci, . [DOI] [Details]
Smyth, VA,Di Lorenzo, D,Kennedy, BN; (2008) 'A novel, evolutionarily conserved enhancer of cone photoreceptor-specific expression'. J BIOL CHEM, 283 :10881-10891. [DOI] [Details]
Coss A, Tosetto M, Fox E, Sapetto-Rebow B, Gorman S, Kennedy B, Lloyd, Hyland J, O'Donoghue D, Sheahan K, Leahy D, Mulcahy H, O'Sullivan J; (2008) 'Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis'. CANCER LETT, . [Details]
Kennedy, B.N.; Yolanda Alvarez; Brockerhoff, S.E.; Stearns, G.; Sapetto-Rebow, B., Taylor, M.R.; and Hurley, J.B.; (2007) 'Identification Of A Zebrafish Cone-Specific Promoter And Genetic Rescue Of Achromatopsia In The nof Mutant'. Invest. Ophth. Vis. Sci, (48):522-529. [Details]
Alvarez, Y,Cederlund, ML,Cottell, DC,Bill, BR,Ekker, SC,Torres-Vazquez, J,Weinstein, BM,Hyde, DR,Vihtelic, TS,Kennedy, BN; (2007) 'Genetic determinants of hyaloid and retinal vasculature in zebrafish'. Development, 7 . [DOI] [Details]
Kennedy, BN, Alvarez, Y, Brockerhoff, SE, Stearns, GW, Sapetto-Rebow, B, Taylor, MR, Hurley, JB, ; (2007) 'Identification of a zebrafish cone photoreceptor - Specific promoter and genetic rescue of achromatopsia in the nof mutant'. Investigative Ophthalmology &Amp; Visual Science, 48 :522-529. [Details]
Alvarez Y, Cederlund ML, Cottell DC, Bill BR, Ekker SC, Torres-Vazquez J, Weinstein BM, Hyde DR, Vihtelic TS, Kennedy BN; (2007) 'Genetic determinants of hyaloid and retinal vasculature in zebrafish'. BMC Developmental Biology, 7 (1). [Details]
Kennedy, B. N., Stearns, G. W., Smyth, V. A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J. B., and Brockerhoff, S. E.; (2004) 'Zebrafish rx3 and mab21l2 are Required During Eye Morphogenesis'. Developmental Biology, 270 :336-349. [Details]
Brockerhoff, S.E., Rieke, F., Matthews, H.R., Cilluffo, M.C., Fain, G.L., Taylor, M.R., Kennedy, B.N, Irina Ankoudinova, I., Xiao, M., Niemi, G.A., Tucker, C.L. and Hurley, J.B.; (2003) 'Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and a suppression of current in cones from the zebrafish mutant nof'. Journal of Neuroscience, 23 :470-480. [Details]
Kennedy, B.N., Li, C., Ortego, J., Coca-Prados, M., Sarthy, V.P. and Crabb, J.W.; (2003) 'CRALBP Transcriptional Regulation in Ciliary Epithelial, Müller and Retinal Pigment Epithelial Cells'. Experimental Eye Research, (76):257-260. [Details]
Kennedy, B.N., Vihtelic, T.S., Checkley, L, Vaughan, K.T. and Hyde D.; (2001) 'Isolation of a Zebrafish Rod Opsin Promoter to Generate a Transgenic Zebrafish Line Expressing EGFP in Rod Photoreceptors'. Journal of Biological Chemistry, 276 :14037-14043. [Details]
Saari, J.C., Nawrot, M., Kennedy, B.N., Garwin, G.G., Hurley, J.B., Huang, J., Possin, D.E. and Crabb, J.W.; (2001) 'Visual Cycle Impairment in the Cellular Retinaldehyde-Binding Protein (CRALBP) Knockout Mice Results in Delayed Dark Adaptation'. Neuron, 29 :739-748. [Details]
Kennedy, B.N., Goldflam, S., Chang, M.A., Campochiaro, P.A., Davis, A.A., Zack, D.J., and Crabb, J.W.; (1998) 'Transcriptional regulation of the human gene encoding cellular retinaldehyde-binding protein'. Journal of Biological Chemistry, 273 :5591-5598. [Details]
Sarthy, V., Brodjian, S., Dutt, K., Kennedy, B.N, French, R., and Crabb, J.; (1998) 'Establishment and characterization of a retinal Müller cell line'. IOVS, 39 :212-216. [Details]
Kennedy, B.N., Huang, J., Saari, J.C. and Crabb, J.W; (1998) 'Molecular characterization of the mouse gene encoding cellular retinaldehyde-binding protein'. Molecular Vision, 4 . [Details]
Maw, M.A., Kennedy, B.N., Knight, A., Bridges, R., Roth, K., Mani, E., Mukkadan, J., Nancarrow, D., Crabb, J.W., and Denton, M.J.; (1997) 'R150Q mutation of cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa'. Nature Genetics, 17 :198-200. [Details]
 

Conference Publications

Stephanie Merrigan, Orla Galvin, Alison Reynolds, Breandan N Kennedy (2015) Vitamin D Receptor Agonists Significantly Attenuate Ocular Developmental Angiogenesis Investigative Ophthalmology & Visual Science [Details]
Clare T Butler, Adrian Murphy, William M Gallagher, Jacintha O'Sullivan, Breandán Kennedy (2015) Phenotype-based development of novel therapies for the treatment of colorectal cancer Cancer Research [Details]
Claire Kilty, Adolfo Lopez-Noriega, Camille Hurley, Neil O'Conner, Alison Reynolds, Cormac Murphy, Fergal O'Brien, Breandan N Kennedy (2015) Sustained Release from Biodegradable Microparticles of Bioactive Cysteinyl Leukotriene Receptor Antagonists for the Treatment of Ocular Neovascularisation Investigative Ophthalmology & Visual Science [Details]
Temitope Sasore, Roisin Dunne, Breandan N Kennedy (2015) Can drug combinations targeting PI3K/Akt/mTOR pathway inhibit angiogenesis, inflammation or permeability in human RPE and endothelial cell lines? Investigative Ophthalmology & Visual Science [Details]
Breandan N Kennedy, Yolanda Alvarez, Claire Kilty, Orla Galvin, Clare Butler, Stephanie Merrigan, Temitope Sasore, Carmel McVicar, Alan W Stitt, Alison Reynolds (2015) Phenotype-Based Discovery of Cysteinyl Leukotriene Receptor Antagonists as Novel Inhibitors of Developmental and Pathological Ocular Angiogenesis Investigative Ophthalmology & Visual Science , pp.5848-5848 [Details]
Conor Daly, Lisa Shine, Eugene Dillon, Theresa Heffernan, Alison Reynolds, David Duffy, Gerard Cagney, Breandan N Kennedy (2015) PHARMACOLOGICAL RESTORATION OF VISUAL FUNCTION IN A BLIND ZEBRAFISH MUTANT FOLLOWING HDAC INHIBITOR (HDACi) TREATMENT Investigative Ophthalmology & Visual Science [Details]
Collery, RE,Cederlund, ML,Smyth, VA,Kennedy, BN (2006) RETINAL DEGENERATIVE DISEASES Applying transgenic zebrafish technology to study the retina , pp.201-207 [Details]
Collery, RF,Kennedy, BN (2010) RETINAL DEGENERATIVE DISEASES: LABORATORY AND THERAPEUTIC INVESTIGATIONS Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish , pp.55-61 [DOI] [Details]
Atzei, P., Maguire, P. B., Kennedy, B. N., Moynagh, P. N., ; (2008) Journal of Neuroimmunology Cactin, a novel regulator of TLR signalling pathways , pp.162-162 [Details]
                       

Abstract

Kennedy, BN,Bhattacharya, SK,Crabb, JS,Bonilha, VL,Crabb, JW (2004) Preliminary in vivo analysis of CRALBP transcriptional regulation. Abstract [Details]
Atzei, P,Maguire, PB,Kennedy, BN,Moynagh, PN (2008) Cactin, a novel regulator of TLR signalling pathways. Abstract [Details]
Green, A,Casey, J,Kawaguchi, R,Morrissey, M,Sun, H,McGettigan, P,Nielsen, J,Conroy, J,Regan, R,Tormey, P,Chroinin, MN,Kennedy, B,Lynch, SA,Ennis, S (2011) First implication of STRA6 mutations in isolated anophthalmia, microphthalmia and coloboma. Abstract [Details]
Cathcart, MC,Mehigan, B,Mc Cormick, P,Kennedy, BN,O'Sullivan, J,Pidgeon, GP,Reynolds, JV (2012) Eicosanoid signalling pathways as potential therapeutic targets in gastrointestinal cancer. Abstract [Details]
Moriarity, AR,Murphy, A,Cathcart, M,Kennedy, BN,Murphy, P,McCormick, PH,O'Sullivan, JN,Mehigan, BJ (2013) Assessing novel small molecule drugs as potential new therapeutic options to treat colorectal cancer. Abstract [Details]
Leyden, C., Reynolds, A., McBean, G., Kennedy, B, Montgomery, T. M. (2014) Establisment of an in vivo screening assay for novel teratogemic compounds in Zebrafish. Abstract [Details]
Smyth, V.A.; Heffernan, T.A.; Di Lorenzo, D.; Kennedy, B.N; (2006) A Novel 20 bp Enhancer Region Controls Cone-specific Expression. Abstract [Details]
RF Collery, ML Cederlund and BN Kennedy; (2006) Transgenic Expression of Human RetGC-1 in Zebrafish Cone Photoreceptors. Abstract [Details]
Y Alvarez, E Breen, B Bill, J Torrez-Vazquez, T Vihtelic and B.N. Kennedy; (2006) Zebrafish: A Novel Model to Characterise Genetic Determinants of Retinal Vasculature. Abstract [Details]
Smyth, V.A.; Heffernan, T.A.; Di Lorenzo, D.; Kennedy, B.N.; (2006) Characterisation of an Enhancer within the 5' flanking region of the Zebrafish Cone Transducin -subunit. Abstract [Details]
Cederlund M, Sapetto-Rebow B, O'Callaghan L, Kennedy B.N.; (2006) Regulation and function of zebrafish mab21l1 and mab21l2 genes. Abstract [Details]
Y. Alvarez, E. Breen, B. Bill, J. Torres-Vazquez, T. Vihtelic and B.N. Kennedy; (2006) Zebrafish: A Novel In Vivo Model To Identify And Characterise Genetic Determinants Of Retinal Vasculature. Abstract [Details]
M. Cederlund, M. Ader, B. Sapetto-Rebow, B.N. Kennedy; (2006) Regulation and function of Mab21l1 and `Mab21l2 genes. Abstract [Details]
B.N. Kennedy Y. Alvarez, Cederlund, M., Collery, R. &. Smyth, V.; (2005) Genetic Determinants of cone photoreceptor development and function. Abstract [Details]
Y. Alvarez, U. Fearon, D. Veale & B.N. Kennedy; (2005) Characterisation Of The Zebrafish Retinal Vasculature. Abstract [Details]
M.C. Cederlund, R.F. Collery, & B.N. Kennedy; (2005) Generating transgenic zebrafish expressing human RetGC-1. Abstract [Details]
Kennedy, B.N., Bhattacharya, S, Crabb, J.S., Bonilha, V.L. and Crabb J.W.; (2004) Preliminary In Vivo Analysis of CRALBP Transcriptional Regulation. Abstract [Details]
Kennedy, B.N.; Collery, Ross; Cederlund, Maria; Hurley, James and Brockerhoff, Susan.; (2004) Determinants Of Cone Photoreceptor Function And Survival. Abstract [Details]
Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E; (2003) Rx3 is required for eye development. Abstract [Details]
Kennedy, B.N., Stearns, G.W., Ankoudinova I., Raible, D., Hurley, J.B. and Brockerhoff, S.E; (2002) Visual and Photoneuroendocrine System Development in eym and TG(TCP-EGFP). Abstract [Details]
Kennedy, B.N., Shelton, S., Brockerhoff, S. and Hurley, J.; (2001) Gene regulation and function in zebrafish cone photoreceptors. Abstract [Details]
Kennedy, B.N., Shelton, S., Brockerhoff, S. and Hurley, J.; (2001) Gene regulation and function in zebrafish cone photoreceptors. Abstract [Details]
Saari, J.C., Nawrot, M., Kennedy, B.N., Hurley, J.B., Garwin G.G., Huang, J., and Crabb, J.W.; (2000) CRALBP is required for a normal rate of 11-cis-retinal synthesis. Abstract [Details]
Kennedy, B.N., Vihtelic, T.S., Checkley, L. and Hyde, D.R.; (2000) Retina-specific transgene expression in zebrafish. Abstract [Details]
Kennedy, B.N., Checkley, L., Vihtelic, T.S., and Hyde, D.R; (1999) Cloning the zebrafish genes for rod and ultraviolet opsin. Abstract [Details]
Hyde, D.R., Kennedy, B.N., Milligan, S.C., Elagina, R,B., Besharse, J.C.; (1999) Expression of dominant RdgB transgenes in Drosophila and Xenopus. Abstract [Details]
Kennedy, B.N., Huang, J., Saari, J.C. and Crabb, J.W.; (1998) Characterization of the mouse CRALBP gene. Abstract [Details]
Ortego, J., Kennedy, B.N., Crabb, J.W. and Coca-Prados,; (1998) CRALBP gene regulation in ciliary epithelial cells. Abstract [Details]
Kennedy, B.N., Maw, M.A., Hulmes, J.D., Knight, A., Bridges, R., Roth, K., Mani, E., Mukkadan, J., Nancarrow, D., Denton, M.J. and Crabb, J.W; (1997) Autosomal recessive retinitis pigmentosa: characterization of a recombinant CRALBP mutant. Abstract [Details]
Brodjian, S., Kennedy, B.N., Crabb, J.W. and Sarthy, V.; (1997) Regulation of the cellular retinaldehyde-binding protein (CRALBP) gene in Müller cells. Abstract [Details]
Kennedy, B.N., Huang, J., Saari, J.C. and Crabb, J.W.; (1997) Comparison of the promoter regions of the mouse and human cellular retinaldehyde-binding protein (CRALBP) genes. Abstract [Details]
Kennedy, B.N., Chang, M.A., Campochiaro, P., Zack, D.J. and Crabb, J.W.; (1996) Potential regulators of CRALBP gene expression. Abstract [Details]
Chang, M.A., Kennedy, B.N., Crabb, J.W., Hackett, S., Campochiaro, P., and Zack, D.J.,; (1995) Mobility shift assay of human CRALBP promoter. Abstract [Details]
Kennedy, B.N., Goldflam, S., Chang, M.A., Hacket, S., Campochiaro, P., Davis, A., Zack, D.J., and Crabb, J.W.; (1995) Promoter analysis of the human CRALBP gene. Abstract [Details]
Saari, J.C., Huang, J., Champer, R.J., Kennedy, B.N., Goldflam, S., and Crabb, J.W.; (1995) Cloning of the mouse gene encoding cellular retinaldehyde-binding protein (CRALBP). Abstract [Details]
       

Reviews

Kennedy, B,Malicki, J (2009) What Drives Cell Morphogenesis: A Look Inside the Vertebrate Photoreceptor. Reviews [DOI] [Details]
                                         

Published abstracts

V.A. Smyth, B.N. Kennedy.; (2005) Identification of an enhancer within the 5 flanking region of the ConeTransducin á-subunit. Published abstracts [Details]
B.N. Kennedy, R.F. Collery, J.M. Finnegan.; (2005) Characterisation of zebrafish CRALBP orthologues. Published abstracts [Details]
         

Research

Research Interests

 

Our goal is to develop genetic and pharmacological treatments for human blindness.  Using zebrafish as an in vivo system, we have identified several families with inherited blindness and have used these to characterise disease progression and evaluate therapies.  We have also developed in vivo assays enabling us to discover novel drugs with specific neuroprotectant, anti-angiogenic or toxic propertiers in the eye. 
 

Technology platforms include: zebrafish : development, expression profiling, genetics, transgenics, morphants and drug screens; Retina: Morphology and Function.

Research Projects

Sponsor : Irish Research Council (IRC)
Title : Vitamin D analogues: a breakthrough for the treatment and prevention of blindness in the elderly and diabetics
Start Date / End Date : 01-OCT-15 / 30-SEP-17
Sponsor : Science Foundation Ireland (SFI)
Title : NFOT Workshop
Start Date / End Date : 01-SEP-15 / 29-FEB-16
Sponsor : University College Dublin (UCD)
Title : Genetic Analysis of Cone Photoreceptors
Start Date / End Date : 01-JUN-04 / 31-MAY-06
Sponsor : Science Foundation Ireland (SFI)
Title : Investigation of circadian gene expression in zebrafish
Start Date / End Date : 09-FEB-09 / 08-MAY-09
Sponsor : Science Foundation Ireland (SFI)
Title : Determination of Changes in Historic Modifications Associated with Transcriptional Activation of Two Genes Involved in Eye Development and Function
Start Date / End Date : 01-MAR-09 / 31-MAR-09
Sponsor : University College Dublin (UCD)
Title : Genetics of the zebrafish shadow response
Start Date / End Date : 03-AUG-09 / 31-JAN-11
Sponsor : Enterprise Ireland (EI)
Title : Development of Anti-Angiogenics for Retina and Tumours
Start Date / End Date : 01-JUL-09 / 31-JUL-09
Sponsor : University College Dublin (UCD)
Title : The raf gene is required for photoreceptor outer segment morphogenesis and is associated with juvenile blindness
Start Date / End Date : 17-MAY-10 / 16-NOV-11
Sponsor : University College Dublin Foundation Ltd.
Title : Newman Fellowship in Colorectal Cancer - Dr Aidan Murphy
Start Date / End Date : 01-JUL-10 / 30-JUN-12
Sponsor : University College Dublin (UCD)
Title : M.Sc. Biotechnology research supervision
Start Date / End Date : 06-MAY-11 / 07-MAY-12
Sponsor : University College Dublin (UCD)
Title : Pim oncogenes, downstream targets of JAK-STAT, mediate visual function development
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : University College Dublin (UCD)
Title : Maintaining Visual Function with Histone Deacetylase Inhibitors
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Enterprise Ireland (EI)
Title : Enhanced Discovery, Development & Delivery of Novel Eye Therapeutics.
Start Date / End Date : 13-FEB-12 / 19-APR-12
Sponsor : Enterprise Ireland (EI)
Title : Drug discovery and development for novel eye therapeutics
Start Date / End Date : 01-NOV-12 / 31-JAN-13
Sponsor : University College Dublin (UCD)
Title : TRANSGENIC ZEBRAFISH EXPRESSING MUTANT HUMAN RETGC-1 EXHIBIT ABERRANT CONE AND ROD MORPHOLOGY
Start Date / End Date : 01-MAY-13 / 31-DEC-14
Sponsor : University College Dublin (UCD)
Title : MSc Student Project Supervision BK
Start Date / End Date : 06-JUN-13 / 30-SEP-15
Sponsor : Irish Cancer Society (ICS)
Title : Development of Novel Isoquinolone Drugs for the Treatment of Colorectal Cancer
Start Date / End Date : 01-SEP-14 / 30-NOV-14
Sponsor : The Wellcome Trust (WT)
Title : Characterisation Of Novel Factors Regulating Cone Photoreceptor Development, Function And Survival: Target Based Identification Of Novel Neuroprotective Compounds
Start Date / End Date : 01-OCT-15 / 30-SEP-19
Sponsor : Fighting Blindness
Title : Identification of drugs that can safely and effectively maintain visual function.....
Start Date / End Date : 01-MAR-15 / 28-FEB-18
Sponsor : Enterprise Ireland (EI)
Title : VISION:
Start Date / End Date : 23-FEB-15 / 22-AUG-15
Sponsor : Science Foundation Ireland (SFI)
Title : Training Award
Start Date / End Date : 01-JAN-15 / 31-DEC-15
Sponsor : Biochemical Society (BS)
Title : Validation of novel Rx3 targets during early eye morphogenesis
Start Date / End Date : 01-MAY-12 / 01-OCT-12
Sponsor : Health Research Board (HRB)
Title : Developing Improved Therapeutics For Ocular Neovascularisation & Inflammation
Start Date / End Date : 01-OCT-13 / 30-SEP-16
Sponsor : Royal Irish Academy (RIA)
Title : Establishing the use of TALEN technology for gene knock-out studies in zebrafish
Start Date / End Date : 01-JAN-13 / 31-DEC-13
Sponsor : Irish Cancer Society (ICS)
Title : Development of Novel Isoquinolone Drugs for the Treatment of Colorectal Cancer
Start Date / End Date : 01-OCT-13 / 30-SEP-17
Sponsor : Enterprise Ireland (EI)
Title : VISION: Inhibitors of Ocular Neovascularisation Stage II
Start Date / End Date : 01-FEB-13 / 30-SEP-14
Sponsor : Science Foundation Ireland (SFI)
Title : SFI Internship
Start Date / End Date : 25-MAR-13 / 24-MAR-14
Sponsor : Irish Research Council (IRC)
Title : Developing Intravitreal Microparticles For Delivery Of Small Molecule Inhibitors of Ocular Neovascularisation
Start Date / End Date : 01-OCT-13 / 06-NOV-15
Sponsor : Science Foundation Ireland (SFI)
Title : Developing Intravitreal Microparticles as a Delivery Mechanism for Small Molecule Inhibitors of Ocular Neovascularisation and Inflammation
Start Date / End Date : 01-JAN-14 / 30-NOV-15
Sponsor : EC Framework (FP7)
Title : 3DNET
Start Date / End Date : 01-SEP-13 / 31-AUG-17
Sponsor : The Wellcome Trust (WT)
Title : Isolation and Determination of the raf gene
Start Date / End Date : 02-JUN-14 / 31-JUL-14
Sponsor : Enterprise Ireland (EI)
Title : Vision: Inhibitors of Ocular Neovascularisation
Start Date / End Date : 01-JAN-12 / 31-DEC-12
Sponsor : Science Foundation Ireland (SFI)
Title : Development of novel inhibitors of ocular neovascularisation
Start Date / End Date : 01-JAN-12 / 30-SEP-13
Sponsor : Irish Research Council (IRC)
Title : Discovery and development of novel anti-angiogenic drugs for treatment of ocular diseases
Start Date / End Date : 01-SEP-12 / 31-AUG-15
Sponsor : University College Dublin (UCD)
Title : Drug Modulators of Vision
Start Date / End Date : 01-MAY-11 / 31-OCT-12
Sponsor : Enterprise Ireland (EI)
Title : Small molecule anti-angiogenics for retinal therapy (SMART)
Start Date / End Date : 01-DEC-09 / 30-NOV-10
Sponsor : Science Foundation Ireland (SFI)
Title : Defining the targets of RX3, an essential gene for eye development
Start Date / End Date : 01-SEP-08 / 31-AUG-11
Sponsor : Fighting Blindness
Title : Directing retinal stem cells to become functionally integrated cone photoreceptors in Host retinas
Start Date / End Date : 01-JUN-07 / 01-JUN-11
Sponsor : Science Foundation Ireland (SFI)
Title : Applying Transgenic Zebrafish Technology to Characterize In Vivo the Molecular Regulators of Cone Photoreceptor Specification
Start Date / End Date : 01-AUG-05 / 31-JAN-09
Sponsor : Science Foundation Ireland (SFI)
Title : Characterising Regulators of Cone Photoreceptor Gene Expression
Start Date / End Date : 01-MAY-05 / 24-JUL-05
Sponsor : American Health Assistance Foundation (AHAF)
Title : Novel Cone-specific genes - Therapeutic targets for MD
Start Date / End Date : 01-APR-05 / 30-SEP-07
Sponsor : Science Foundation Ireland (SFI)
Title : Genome - Wide Screens for Determinants of Cone Photoreceptor Function
Start Date / End Date : 01-SEP-04 / 30-AUG-08
Sponsor : Health Research Board (HRB)
Title : In Vivo Models of Human Blindness Characterised by Cone-Rod Dystrophy
Start Date / End Date : 15-OCT-03 / 14-OCT-06
Sponsor : Science Foundation Ireland (SFI)
Title : Identification and Characterisation of Muscular regulators of Circadian Rhythms
Start Date / End Date : 01-SEP-06 / 28-FEB-10
Sponsor : Science Foundation Ireland (SFI)
Title : Genetic screens for cone photoreceptor determinants
Start Date / End Date : 18-MAY-06 / 28-AUG-08
Sponsor : Science Foundation Ireland (SFI)
Title : Identification and characterisation of genetic determinants of retinal vasculature using zebrafish
Start Date / End Date : 01-SEP-06 / 28-FEB-10
Sponsor : Health Research Board (HRB)
Title : Applying zebrafish to identify and characterise retinal vasculature development
Start Date / End Date : 01-JUL-06 / 31-AUG-09
Sponsor : Health Research Board (HRB)
Title : CRALBP function in vision and circadian rhythms
Start Date / End Date : 01-OCT-06 / 31-DEC-09

Recent Postgraduates

  • ross collery
  • vincent smyth
  • maria cederlund
  • sarah mcloughlin
  • maria morrissey
  • theresa heffernan

Current Postgraduate Students

Jessica Garcia Fernandez, Master of Science (MSc)   -   Thesis Supervisor
Stephanie Merrigan, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Conor Daly, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Temitope Sasore, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Stephen Carter, Doctor of Philosophy (PhD)   -   Thesis Co-Supervisor
Andrew Smith, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Clare Butler, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

Teaching Philosophy

Knowledge is best acquired by students when provided with the core information, insightful examples or analogies and when they are provided with opportunities to critically think about the subject. Re-enforcing knowledge of the material by alternative learning approaches e.g. practical classes, CALS, case studies or student presentations is critical.e

Modules Coordinated

201500   BIOC40160     Biochemistry: Drug Develop & Clinical Trials
201500   PHAR20030     Pharmacology: Pharmacology
201500   PHAR40040     Pharmacology: Emerging therapies
     

Innovation & Leadership

Head of Pharmacology at UCD. Responsible for managing the BSc Pharmacology degree programme. Responsible for annual review of the overall quality of the contribution of Pharmacology to degrees in Science, Nursing and Medicine.

Collaborators

Internal Collaborators

  • Dr Yolanda Alvarez
  • Prof. Matthias Tacke
  • Dr. Alison Reynolds
  • Dr. John Crean
  • Dr. Albert Smolenski
  • Dr. John O'Connor
  • Prof. William Gallagher
  • Dr. Carmel Hensey


External Collaborators

Dr. Susan Brockerhoff
University of Washington
http://depts.washington.edu/biowww/directories/faculty/brockerhoff.html

Prof. John Crabb
Cleveland Clinic Foundation
http://www.lerner.ccf.org/eye/crabb/

Prof. James Hurley
University of Washington
http://faculty.washington.edu/jbhhh/

Prof. Jack Saari
University of Washington
http://depts.washington.edu/ophthweb/saari.html 
 
Prof. David Hyde 
University of Notre Dame 
 
Prof. Alan Stitt 
Queens University Belfast

Prof. Jean Louis Reymond
University of Bern

Prof. Peter Humphries
Trinity College Dublin