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Chandralal Hewage

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Biography

I have been working in the field of NMR spectroscopy for the last 25 years. I started my research career using a Varian 60 MHz electro magnet for the characterization and identification of antibacterial and insecticidal compounds from natural products at the University of Peradeniya, Srilanka. Then I moved to the University of Edinburgh to study the structural properties of Endothelin peptides using the then state of the art 600 MHz Varian spectrometer. Soon after completing my PhD degree at Edinburgh I accepted the NMR Scientist position at the UK national NMR centre. In 1999 I moved to the University College Dublin to start a new position at the Biological NMR centre in the Conway Institute where I still remain. Currently I am attached to the UCD School of Biomolecular and Biomedical Science. 

I have keen interest on the NMR investigations and molecular modeling of biologically active peptides and its analogues. In addition my main research areas lie in the design and development of GIP and Endothelin receptor drugs, NMR studies of the metabolic functions of liver cells in different liver diseases, structure activity relationship studies of antimicrobial peptides for the development of new antimicrobial agents. I am an author of more then 100 research articles, short communications and conference proceedings. I have also managed to secure funds from variety of research funding bodies. Recently I organised the International NMR Conference, EUROMAR 2012 in University College Dublin on 1-5 July 2012. I am given the opportunity to organize prestigious EPS symposium and ICMRBS conference in Dublin in 2018.  
 
Research Links:  SBBS Research  |  Biotechnology & Synthetic Biology Research in SBBS  |  Mechanisms of Disease Research in SBBS 

Chandralal Hewage, Conway, NMR, Ireland, UCD, University College Dublin, Chemistry, Biochemistry, Structural biology, modelling, diabetes, antimicrobial, protein, peptide, GIP structure, GPCR structure, postgraduate studies , postdoctoral, EUROMAR, EPS, ICMRBS, IUBMB 


Professional

             

Employment

Employer: University College Dublin
Position: NMR Manager
Employer: University College Dublin
Position: Wellcome Trust Senior Research Fellow
Employer: University of Edinburgh, Scotland
Position: BBSRC Research Fellowship
Employer: University of Edinburgh, Scotland
Position: Parke Davis Research Fellowship
Employer: University of Edinburgh, Scotland
Position: NMR Scientist, UK National High-Field NMR Centre

Education

Year 1995 Institution: University of Edinburgh
Qualification: PhD - NMR Spectroscopy Subject: Science
Year 1985 Institution:
Qualification: BSc Subject:
Year 1989 Institution:
Qualification: MPhil Subject:
         

Publications

     

Peer Reviewed Journals

Venneti KC, Alana I, O'Harte FP, Malthouse JP, Hewage CM.; (2008) 'Conformational studies of GIP in membrane mimicking environment: Studies towards the bioactive conformation'. JOURNAL OF BIOLOGICAL CHEMISTRY, . [Details]
Anusha P Subasinghage AP. Conlon JM, Hewage CM; (2008) 'Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif'. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, . [Details]
Hewage CM, Alana I, O'Harte FPM; (2007) 'Structural studies of glucose-dependent insulinotropic polypeptide (GIP) in micellular media'. Diabetologia, 50 (1):0593-0593. [Details]
Brennan L, Scullion SM, Mion B, Hewage C, Malthouse JG, Flatt PR, Newsholme P, McClenaghan NH. ; (2007) 'Prolonged alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic beta cells'. Diabetologia, 50 (1):0509-0509. [Details]
Cosgrove S, Rogers L, Hewage CM, Malthouse JP.; (2007) 'NMR Study of the Inhibition of Pepsin by Glyoxal Inhibitors: Mechanism of Tetrahedral Intermediate Stabilization by the Aspartyl Proteases'. BIOCHEMISTRY, . [Details]
Cadogan JI, Hewage CM, McNab H, Macpherson AD, Nicolson IS, Reed D, Sadler IH.; (2006) 'Generation and contrasting gas-phase reactivity of 2-(2-alkenylpyrrol-1-yl)phenoxyl and thiophenoxyl radicals'. ORGANIC & BIOMOLECULAR CHEMISTRY, . [Details]
Alana I, Malthouse JP, O'Harte FP, Hewage CM. ; (2007) 'Bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy'. PROTEINS: Structure, Func. and Bioinfor, 68 (1):92-99. [Details]
Spink E, Cosgrove S, Rogers L, Hewage C, Malthouse JP.; (2007) '13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes'. Journal of Biological Chemistry, 282 (11):7852-7861. [Details]
Brennan, L; Hewage, C; Malthouse, JPG; McClenaghan, NH; Flatt, PR; Newsholme, P; ; (2006) 'Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism'. FEBS Journal, 273 (22):5160-5168. [Details]
Brennan, L., Hewage, C., Malthouse, J.P.G., McClenaghan, N.H., Flatt, P.R., Newsholme, P.; (2006) 'NMR analysis reveals prolonged sulphonylurea exposure impacts on the regulation of pancreatic beta-cell metabolism'. FEBS JOURNAL, 273 :5160-5168. [Details]
Alana, I; Parker, JC; Gault, VA; O'Harte, FPM; Malthouse, JPG; Hewage, CM; ; (2006) 'NMR and modelling studies of glucose-dependent insulinotropic polypeptide (GIP)'. Journal of Peptide Science, 12 (NA):185-185. [Details]
Brennan L, Hewage C, Malthouse JG, McClenaghan NH, Flatt PR, Newsholme P.; (2005) 'Effects of anti-diabetic drugs on beta cell glucose metabolism in a clonal cell line, BRIN-BD11'. DIABETOLOGIA, 48 :A163-A163. [Details]

Other Journals

Cadogan, J.I., Hewage, C.M., McNab, H., Macpherson, A.D., Nicolson, I.S., Reed, D., Sadler, I.H.; (2006) 'Generation and contrasting gas-phase reactivity of 2-(2-alkenylpyrrol-1-yl)phenoxyl and thiophenoxyl radicals' Org Biomol Chem 4 (12) :2446-2451. [Details]
Alana, I., Parker, J.C., Gault, V.A., Flatt, P.R., O'Harte, F.P., Malthouse, J.P., Hewage, C.M.; (2006) 'NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water' J. Biol. Chem 281 (24) :16370-16376. [Details]
Dabos KJ, Nelson LJ, Hewage CH, Parkinson JA, Howie AF, Sadler IH, Hayes PC, Plevris JN ; (2004) 'Comparison of bioenergetic activity of primary porcine hepatocytes cultured in four different media' Cell Transplant 13 (3) :213-229. [Details]

Conference Publications

Brennan, L., Hewage, C., Malthouse, J.P.G, Colhoun, H.; (2006) Analysis of metabolic profiles of biofluids from patients with type 1 Diabetes Mellitus Metabolomics Conference Boston, USA, , 24-JUN-06 - 29-JUN-06 [Details]
Brennan, L., Hewage, C., Malthouse, J.G., McCenaghan, N.H., Flatt, P.R. and Newsholme P.; (2005) Effects of anti-diabetic drugs on beta cell glucose metabolism in a clonal cell line, BRIN-BD11 EASD Athens, Greece, , 12-SEP-05 - 15-SEP-05 [Details]
                                                                                         

Research

Research Interests

                      

Structurlal Biology of peptides related to Diabetes and Obesity

Design and development of GIP and Endothelin receptor drugs

Structural studies of antimicrobial peptides for the development of new antimicrobial agents

NMR studies of the metabolic functions of liver cells in different liver diseases

Development of NMR techniques

Structural elucidation of biologically important molecules by multidimensional NMR

Studies of Phytochemicals for diabetes thearapy

Molecular modelling methods of macromolecules

Bioinformatics study for Ligand-Protein interactions