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Darran O'Connor

Senior Lecturer

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: 7166751
Email: darran.oconnor@ucd.ie

Biography

I obtained my PhD from Trinity College Dublin in 2000. Subsequently, I conducted my postdoctoral training in cancer biology at Columbia University, New York and at the University of Glasgow under the supervision of Prof Nick La Thangue, FRSE. Afterwards, I returned to Ireland as a HRB Career Development Fellow and, in 2009, was employed in a permanent capacity as a Research Fellow in Cancer Biology at UCD within the School of Biomolecular and Biomedical Science and appointed as Senior Lecturer in Cancer Biology within SBBS in 2013. At present, I lead a team of 3 postdoctoral fellows and 3 PhD students (with 4 previous PhD students graduated) funded by the European Commission, Science Foundation Ireland, The Irish Cancer Society and the Irish Research Council for Science, Engineering and Technology. My group has extensive experience in the discovery of molecular determinants of cancer progression (via transcriptomic/proteomic profiling and functional genomic screening) and their clinical translation through the development and automated analysis of tissue microarrays, in addition to their functional analysis using in vitro models and xenograft studies in nude mice. As such, we have established an integrated workflow for the molecular and clinical analysis of central tumourigenic processes that we are currently applying to a number of different tumour types. Based on this work I was elected to the council of the Irish Association for Cancer Research in 2011 and was awarded the 9th St Luke's Young Investigator award in 2012 and an EACR Young Scientist Award in 2009. Additionally, I have been awarded a number of prestigious fellowships, notably from the Health Research Board, the European Molecular Biology Organisation and the Human Frontiers Science Programme and have spent additional time as a Visiting Fellow at the Dana-Farber Cancer Institute/Harvard Medical School and the Netherlands Cancer Institute where I joined the group of Prof Rene Bernards. I have published 33 articles to date in Nature Cell Biology, Nature Reviews Cancer, Oncogene, EMBO Reports, Cancer Research and Clinical Cancer Research among others.

Professional

Honours and Awards

Year: 2012.
Title: UICC ICRETT Fellowship
Year: 2012.
Title: St Luke's Young Investigator Award
Year: 2009.
Title: EACR Young Researcher Award
Year: 2006.
Title: HRB Career Development Fellowship
Year: 2006.
Title: UICC ICRETT Fellowship
Year: 2007.
Title: HFSP Short Term Fellowship
Year: 2007.
Title: EMBO Short Term Fellowship

Associations

Association: All-Ireland Cooperative Oncology Research Group (ICORG), Function/Role: Member
Association: American Society of Clinical Oncology, Function/Role: Member
Association: Metastasis Research Society, Function/Role: Member
Association: American Association for Cancer Research, Function/Role: Member
Association: European Association for Cancer Research, Function/Role: Member
Association: British Association for Cancer Research, Function/Role: Member
Association: Irish Association for Cancer Research, Function/Role: Council Member

Patents

Patent 60/799,479 : Methods and compositions for identifying and using p21-regulated proteins.
   

Conference Contributions

O'Connor DP, Martin FM, Gallagher WM; (2006) EMBO Molecular Medicine Conference. [Conference Organising Committee Member], Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression, O'Reilly Hall, UCD , 06-JUN-06 - 08-JUN-06.
O'Connor, D. P., O'Donoghue, N., Currid, C. A., Chang, B.-D., Roninson, I. B., Dunn, M. J., Pennington, S. R., and Gallagher, W. M. ; (2006) p21, p16 and p27, more than just cell cycle inhibitors. [Poster Presentation], Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting, Galway , 03-MAR-06 - 04-MAR-06.

Committees

Committee : Breast-Predict, ICS Collaborative Cancer Centre, Steering Committee
Committee : Breast-Predict, ICS Collaborative Cancer Centre, Communications Committee
Committee : SBBS PhD Transfer assessment panel
Committee : SBBS MSc development Committee
Committee : Irish Association for Cancer Research
Committee : AngioPredict Steering Committee (www.angiopredict.com)
Committee : National Cancer Research Centre of Ireland Steering Committee
Committee : Molecular Therapeutics for Cancer Ireland Management Committee (www.mtci.ie)

Employment

Employer: University College Dublin
Position: Research Fellow
Employer: Columbia University, NY
Position: Postdoctoral Research Associate
Employer: University of Glasgow, IBLS
Position: Postdoctoral Research Scientist
Employer: UCD, Department of Pharmacology
Position: Postdoctoral Research Scientist
Employer: Ordway Cancer Centre, Albany, NY
Position: Visiting Researcher, Roninson Lab
Employer: Netherlands Cancer Institute (NKI), Amsterdam
Position: Visiting Researcher, Bernards Lab

Education

Year 1994 Institution: Trinity College Dublin
Qualification: BA (Mod) Subject: Microbiology
Year 1995 Institution: Dublin City University
Qualification: MSc Subject: Biological Sciences
Year 2000 Institution: Trinity College Dublin
Qualification: PhD Subject: Molecular Biology
         

Publications

     

Peer Reviewed Journals

O Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O'Connor DP, Brennan DJ, Connor K, Li J, Gonzalez-Angulo AM, Sun HD, Pu JX, Pontén F, Uhlén M, Jirström K, Nowis DA, Crown JP, Zagozdzon R, Gallagher WM. (2014) 'Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer'. Breast Cancer Research, . [Details]
Mulrane L, Gallagher WM & O¿Connor DP (2014) 'A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer'. Breast Cancer Research, . [Details]
Mulrane L, Klinger R, McGee SF, Gallagher WM, O'Connor DP. (2014) 'microRNAs: a new class of breast cancer biomarkers'. Expert Review of Molecular Diagnostics, . [Details]
Prencipe M, Madden SF, O'Neill A, O'Hurley G, Culhane A, O'Connor D, Klocker H, Kay EW, Gallagher WM, Watson WR. (2013) 'Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target?'. Prostate, 73 (7):743-753. [DOI] [Details]
Mulrane L, McGee SF, Gallagher WM & O'Connor DP (2013) 'microRNA Dysregulation in Breast Cancer'. Cancer Research, . [Details]
Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM & O'Connor DP (2012) 'miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro'. Clinical Cancer Research, 24 (18):6702-6713. [Details]
Hehir MP, Laursen H, Higgins MF, Brennan DJ, O'Connor DP & McAuliffe FM (2012) 'Ghrelin concentrations in maternal and cord blood of Type 1 diabetic and non-diabetic pregnancies at term'. Endocrine, . [Details]
Brennan DJ*, O'Connor DP*, Laursen H, McGee SF, McCarthy S, Rexhepaj E, Culhane AC, Hewitt SM, Bernards R, Martin FM, Duffy MJ, Landberg G, Millikan RC, Crown JP, Jirström K & Gallagher WM. *Equal Contribution (2012) 'The Cocaine and Amphetamine Regulated Transcript mediates Ligand-Independent Activation of ER-alpha and is an Independent Prognostic Factor in Node-Negative Breast Cancer'. Oncogene, 30 (31):3483-3494. [Details]
Nodin B, Johannesson H, Wangefjord S, O'Connor DP, Lindquist KE, Uhlén M, Jirström K, Eberhard J. (2012) 'Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer'. Diagnostic pathology, 30 (7). [Details]
Hehir MP, Laursen H, Higgins MF, Brennan DJ, O'Connor DP & McAuliffe FM (2012) 'Maternal and fetal Cocaine and Amphetamine-Regulated Transcript (CART) in diabetic and non-diabetic pregnancy'. Gynecological Endocrinology, . [Details]
Brennan, D. J., Laursen, H., O'Connor, D., Borgquist, S., Uhlén, M., Gallagher, W. M., Ponten, F., Millikan, R. C., Ryden, L., and Jirstrom, K.; (2011) 'Tumor specific HMG-CoA reductase expression in primary pre-menopausal breast cancer predicts response to tamoxifen'. Breast Cancer Research, 13 (1). [Details]
O'Neill AJ, Prencipe M, Dowling C, Fan Y, Mulrane L, Gallagher WM, O'Connor D, O'Connor R, Devery A, Corcoran C, Rani S, O'Driscoll L, Fitzpatrick JM, Watson RW (2011) 'Characterisation and manipulation of docetaxel resistant prostate cancer cell lines'. MOL CANCER, 10 (126). [Details]
Magnusson K, de Wit M, Brennan DJ, Johnson LB, McGee SF, Lundberg E, Naicker K, Klinger R, Kampf C, Asplund A, Wester K, Gry M, Bjartell A, Gallagher WM, Rexhepaj E, Kilpinen S, Kallioniemi OP, Belt E, Goos J, Meijer G, Birgisson H, Glimelius B, Borrebaeck CA, Navani S, Uhlén M, O'Connor DP, Jirström K & Pontén F (2011) 'SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas'. American Journal of Surgical Pathology, 35 (7):937-948. [Details]
Brennan DJ, McGee SF, Rexhepaj E, O'Connor DP, Robson M & O'Herlihy C. (2011) 'Identification of a Myometrial Molecular Profile for Dystocic Labor'. BMC Pregnancy Childbirth, 1 (11). [Details]
Brennan, D. J., Brandstedt, J., Rexhepaj, E., Foley, M., Ponten, F., Uhlen, M., Gallagher, W. M., O'Connor, D. P., O'Herlihy, C., and Jirstrom, K; (2010) 'Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer'. BMC Cancer, 10 . [Details]
Ehlén A, Brennan DJ, Nodin B, O'Connor DP, Eberhard J, Alvarado-Kristensson M, Jeffrey IB, Manjer J, Brändstedt J, Uhlén M, Pontén F, Jirström K (2010) 'Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer'. Journal of translational medicine, 8 . [Details]
Rexhepaj, E., Jirstrom, K., O'Connor, D. P., O'Brien, S. L., Landberg G., Duffy, M. J., Brennan, D. J., and Gallagher, W. M. ; (2010) 'Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer'. BMC Cancer, 10 . [Details]
Brennan, D. J., O'Connor, D. P., Rexhepaj, E., Ponten, F., and Gallagher, W. M. ; (2010) 'Antibody-based proteomics: fast-tracking molecular diagnostics in oncology'. Nature reviews. Cancer, 10 (9):605-617. [Details]
Brennan, D. J., Ek, S., Doyle, E., Drew, T., Foley, M., Flannelly, G., O¿Connor, D. P., Gallagher, W. M., Kilpinen, S., Kallioniemi, O-P., Jirstrom, K., O¿Herlihy, C., and Borrebaeck, C. A. K. ; (2009) 'The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer'. European Journal of Cancer, 45 (8):1510-1517. [DOI] [Details]
Collins, B. C.,Lau, T. Y.,O'Connor, D. P.,Hondermarck, H.; (2009) 'Cancer proteomics--an evolving battlefield. Conference on Cancer Proteomics 2009: Mechanistic Insights, Technological Advances & Molecular Medicine'. EMBO Rep, 10 (1111):1202-51202. Available Online [Details]
Prencipe, M.,Fitzpatrick, P.,Gorman, S.,Tosetto, M.,Klinger, R.,Furlong, F.,Harrison, M.,O'Connor, D.,Roninson, I. B.,O'Sullivan, J.,McCann, A.; (2009) 'Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro'. Br J Cancer, 101 (1111):1900-81900. Available Online [Details]
Brennan, D. J., Rexhepaj, E., O'Brien, S. L., McSherry, E., O'Connor, D. P., Fagan, A., Culhane, A. C., Higgins, D. G., Jirstrom, K., Millikan, R. C., Landberg, G., Duffy, M. J., Hewitt, S. M., Gallaghe, W. M., ; (2008) 'Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer'. Clinical Cancer Research, 14 (9):2681-2689. [Details]
Lau, TY; O'Connor, DP; Brennan, DJ; Duffy, MJ; Pennington, SR; Gallagher, WM; ; (2007) 'Breast cancer proteomics: clinical perspectives'. Expert Opinion on Biological Therapy, 7 (2):209-219. [Details]
Lanigan, F., O'Connor, D., Martin, E., Gallagher, W. M., ; (2007) 'Common molecular links between mammary gland development and breast cancer'. Cellular and Molecular Life Sciences, 64 (24):3161-3184. [Details]
Currid, CA,O'Connor, DP,Chang, BD,Gebus, C,Harris, N,Dawson, KA,Dunn, MJ,Pennington, SR,Roninson, IB,Gallagher, WM; (2006) 'Proteomic analysis of factors released from p21-overexpressing tumour cells'. Proteomics, 6 (NA):3739-3753. [DOI] [Details]
Gallagher WM, Lynch I, Allen LT, Miller I, Penney SC, O¿Connor DP, Pennington SR, Keenan A & Dawson KA. (2006) 'The Molecular Basis of Cell-Biomaterial Interaction: Time for a Fresh Look Inside?'. Biomaterials, 35 (27):5871-5882. [Details]
McGee SF, O¿Connor DP & Gallagher WM (2006) 'Functional Interrogation of Breast Cancer: From Models to Drugs'. Expert opinion on drug discovery, 6 (1):569-584. [Details]
Markham D, Munro S, Soloway J, O'Connor DP & La Thangue NB (2006) 'DNA-damage-responsive acetylation of pRb regulates binding to E2F-1'. Embo Reports, 7 (2):192-198. [Details]
Collins, BC; O'Connor, DP; Currid, CC; O'Donoghue, N; Pedersen, K; Dunn, MJ; Pennington, SR; Roninson, IB; Gallgher, WM; ; (2006) 'Proteomic analysis of cyclin-dependent kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-gel electrophoresis/peptide mass fingerprinting'. Molecular & Cellular Proteomics, 5 (10):101-101. [Details]
Demonacos C, Krstic-Demonacos M, Smith L, Xu D, O¿Connor DP, Jansson M, & La Thangue NB. (2004) 'A new effector pathway links ATM kinase with the DNA damage response'. Nature Cell Biology, 6 (10):968-976. [Details]
O'Connor DP, Kay E ,Leader M, Atkins GJ, Murphy GM & Mabruk MJ. (2001) 'A high degree of chromosomal instability at 13q14 in cutaneous squamous cell carcinomas: Indication for a role of a tumour suppressor gene other than Rb'. Journal of Clinical Pathology, 54 (3):165-169. [Details]
O'Connor DP, Kay E ,Leader M, Atkins GJ, Murphy GM & Mabruk MJ. (2001) 'Altered p53/p21/mdm2 expression in non-melanoma skin cancers of renal transplant recipients and immunocompetent skin cancer patients: Is there a correlation with HPV?'. Diagnostic pathology, 10 (3):190-199. [Details]
O'Connor DP, Kay E ,Leader M, Murphy GM, Atkins GJ & Mabruk MJ. (2001) 'p53 codon 72 polymorphism and HPV-associated skin cancer'. Journal of Clinical Pathology, 54 (7):539-542. [Details]
O'Connor DP, Bennett MA, Murphy GM & Kay E. (1996) 'Do human papilloma viruses cause skin cancer?'. Current Diagnostic Pathology, 3 :103-110. [Details]
 

Conference Publications

McGee, S.F., O' Connor, D.P., Mc Donnell, S., Duffy, M.J., Gallagher, W.M; (2009) A functional genomics screen identifies serpinB2 as a key mediator of breast cancer progression The Metastasis Research Society-American Association for Cancer Research Conference on Metastasis [Details]
Collins, B.C., O'Connor, D.P., Currid, C.A., Chang, B., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B. & Gallagher, W.M.; (2006) Proteomic analysis of cyclin-dependant kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-Gel electrophoresis/peptide mass fingerprinting 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
O'Connor, D.P., Collins, B.C., Currid, C., Chang, B.-D., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2006) Proteomic analysis of p21-regulated protein expression Gordon Research Conference: Cancer Models and Mechanisms Rhode Island, USA, , 01-AUG-06 - 04-AUG-06 [Details]
O'Connor, D.P., O'Donoghue, N., Currid, C.A., Chang, B.-D., Roninson, I.B., Dunn, M.J., Pennington, S.R., & Gallagher, W.M.; (2006) p21, p16 and p27, more than just cell cycle inhibitors Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
McGee, S., O'Connor, D., Roninson, I., Duffy, M., & Gallagher, W.M.; (2006) Construction of a lentiviral RNAi library for the functional analysis of genes associated with breast cancer metastasis EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
O'Connor, D.P., O'Donoghue, N., Currid, C.A., Chang, B.-D., Roninson, I.B., Dunn, M.J., Pennington, S.R., & Gallagher, W.M.; (2006) p21, p16 and p27, more than just cell cycle inhibitors Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
Whelan, L.C., Murphy, A., Currid, C.A., O'Connor, D., & Gallagher, W.M.; (2006) ProteinChip facility at the Conway Institute: applications of SELDI-MS technology in biomedical research BioTekNet 2006 Meeting Dublin, Ireland, [Details]
Collins, B.C., O'Connor, D.P., Currid, C.A., Chang, B., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B. & Gallagher, W.M.; (2006) Proteomic analysis of cyclin-dependant kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-Gel electrophoresis/peptide mass fingerprinting 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
O'Connor, D.P., Collins, B.C., Currid, C., Chang, B.-D., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2006) Proteomic analysis of p21-regulated protein expression Gordon Research Conference: Cancer Models and Mechanisms Rhode Island, USA, , 01-AUG-06 - 04-AUG-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
McGee, S., McArdle, E., O'Brien, S., Martin, F., O'Connor, D., & Gallagher, W.M.; (2005) Optimisation of a lentiviral delivery system for functional interrogation of breast cancer-associated genes Cold Spring Harbor Laboratory Conference: RNA Interference New York, USA, , 28-SEP-05 - 02-OCT-05 [Details]
Currid, C., O'Connor, D.P., Gebus, C., Chang, B.-D., Harris, N., Dawson, K., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2005) Proteomic analysis of factors released from p21-overexpressing tumour cells HUPO 4th Annual World Congress Berlin, Germany, , 28-AUG-05 - 01-SEP-05 [Details]
McGee, S., McArdle, E., O'Brien, S., Martin, F., O'Connor, D., & Gallagher, W.; (2005) Optimisation of a lentiviral delivery system for functional interrogation of breast cancer-associated genes 3rd Annual National Symposium of the Irish Research Council for Science, Engineering and Technology (IRCSET) Dublin, Ireland, , 03-NOV-05 [Details]
   

Editorial

Collins, B,Lau, TYK,O'Connor, DP,Hondermarck, H; (2009) Cancer proteomics-an evolving battlefield Conference on Cancer Proteomics 2009: Mechanistic Insights, Technological Advances & Molecular Medicine. Editorial [DOI] [Details]
                 

Abstract

Brennan, D,McGee, S,Rexhepaj, E,O'Connor, D,Murphy, M,Robson, M,O'Herlihy, C (2009) Identification of a myometrial molecular profile for dystocic labor. Abstract [Details]
                                                               

Research

Research Interests

Cancer Biology
Molecular Therapeutics
Functional Genomics
Genomics
Translational Pathology
Breast Cancer
Colon Cancer

Research Projects

Sponsor : Irish Cancer Society (ICS)
Title : Collaborative Cancer Research Centre: From population to patient: Leveraging systems medicine to personalise breast cancer treatment (ICS BREAST PREDICT)
Start Date / End Date : 01-OCT-13 / 30-SEP-18
Sponsor : Irish Cancer Society (ICS)
Title : Epigenetic regulation of the angiogenic switch and response to anti-angiogenic therapy in metastatic colorectal cancer
Start Date / End Date : 01-OCT-13 / 30-SEP-16
Sponsor : Irish Cancer Society (ICS)
Title : The role of the anorectic neuropeptide CART in breast cancer
Start Date / End Date : 01-SEP-13 / 31-AUG-17
Sponsor : Science Foundation Ireland (SFI)
Title : Molecular Therapeutics for Cancer Ireland
Start Date / End Date : 01-SEP-12 / 31-AUG-14
Sponsor : EC Framework (FP7)
Title : Angiopredict
Start Date / End Date : 01-FEB-12 / 31-JAN-16
Sponsor : Science Foundation Ireland (SFI)
Title : Development of a novel antibody for the cocaine and amphetamine-regulated transcript
Start Date / End Date : 01-JAN-13 / 30-JUN-14
Sponsor : Enterprise Ireland (EI)
Title : Development of a Diagnostic Test for the Cocaine and Amphetamine-Regulated Transcript: Use in Multiple Cancer Indications
Start Date / End Date : 25-NOV-12 / 31-JUL-13
Sponsor : Science Foundation Ireland (SFI)
Title : The role of SATB2 in Colon Cancer Progression
Start Date / End Date : 01-SEP-08 / 31-AUG-12
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Functional Genomic Investigation of Key Mediators of Breast Cancer Metastasis
Start Date / End Date : 01-OCT-08 / 30-SEP-11
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : The role of the BRCC complex in breast cancer
Start Date / End Date : 01-DEC-11 / 30-NOV-13
Sponsor : Science Foundation Ireland (SFI)
Title : In silico analyses of SATB2 in colorectal cancer.
Start Date / End Date : 01-JAN-12 / 31-DEC-12
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Investigation of the anti-apoptic and mitogenic paracrine effects of p21
Start Date / End Date : 01-OCT-07 / 30-SEP-10
Sponsor : University College Dublin (UCD)
Title : Antibody-free Mass Spectrometry-Based Quantification and Validation of Novel Breast Cancer Biomarkers
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : University College Dublin (UCD)
Title : Application of Mutiplexed Antibody Assays for the Validation of Senescence-Associated Serum Biomakers
Start Date / End Date : 01-DEC-06 / 31-MAY-08
Sponsor : The Wellcome Trust (WT)
Title : Ligand-independent activation of the oestrogen receptor by the anorectic peptide CART
Start Date / End Date : 06-JUL-09 / 31-AUG-09
Sponsor : University College Dublin (UCD)
Title : Publication: miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro
Start Date / End Date : 01-MAY-13 / 31-OCT-14

Recent Postgraduates

Rut Klinger, Cancer Biology, 2012

Laoighse Mulrane, Cancer Biology, 2013

Kirsha Naicker, Cancer Biology, 2013

Henriette Laursen, Cancer Biology, 2013
 

Teaching

Teaching Philosophy

Modules Coordinated

201400   PHAR40020     Pharmacology: Pharmacology Research Project
201400   BMOL40050     Biomolecular & Biomed Science: Adv Pharmacology of Cancer
201400   BIOC40110     Biochemistry: Biomedical Diagnostics

Enhancement of Teaching

Review and Enhancement of Curriculum

Developing as a Teacher

Innovation & Leadership

Collaborators

Internal Collaborators

Prof William Gallagher, SBBS, Conway Institute, UCD [MTCI, RATHER, ANGIOPREDICT, Breast-Predict]

Prof William Watson, UCD [MTCI, NCRCI]

Prof Walter Kolch, UCD [Breast-Predict]

Prof Des Higgins, UCD [Breast-Predict]

Prof Joe Duffy, UCD [MTCI, NCRCI, Breast-Predict]

 

 

 

 

External Collaborators

Prof John Crown, DCU/SVUH [MTCI, NCRCI, Breast-Predict]

Prof Leonie Young, RCSI [Breast-Predict]

Prof Bryan Hennessy, RCSI/Beaumont Hospital [Breast-Predict, MTCI]

Dr Annette Byrne, RCSI [ANGIOPREDICT, Breast-Predict]

Dr Norma O'Donovan, DCU [MTCI, NCRCI, Breast-Predict]

Dr Donal Brennan, University of Queensland, Australia [SATB2 and colon cancer progression, CART]

Prof Karin Jirström, Lund University, Sweden [SATB2 and colon cancer progression, CART, RATHER]

Prof Fredrik Ponten, Uppsala University, Sweden [Human Proteome Resource, www.proteinatlas.org]

Prof Rene Bernards, NKI, Amsterdam, The Netherlands [BRCC3 and Breast Cancer, RATHER]

Prof Igor Roninson, University of South Carolina, USA [p21 and senescence]

Prof Diether Lambrechts, VIB, Leuven, Belgium [ANGIOPREDICT]

Dr Aedin Culhane, Dana Farber Cancer Institute, Boston, MA, USA [SATB2 and colon cancer progression, CART]

Prof Bauke Ylstra, VuMC, Amsterdam [ANGIOPREDICT]

Prof Matthias Ebbert, University of Heidelberg [ANGIOPREDICT]