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Gerard Cagney

School of Biomolecular & Biomedical Science

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Biography

June 2003-June2004: Director of Proteomics, Royal College of Surgeons in Ireland
January 2003-June 2004: Senior Lecturer, Royal College of Surgeons in Ireland
January 2001 - December 2002: Project Leader, Genome Canada Proteomics Program, University of Toronto, Canada
May 2000 - December 2001: Postdoc, Andrew Emili Lab, Program in Proteomics & Bioinformatics, University of Toronto, Canada
November 1997 - April 2000: Postdoc, Stanley Fields Lab, University of Washington, Seattle, USA
March 1994-October 1997: Research Scientist, Elan Pharmaceutical Technologies, Dublin, Ireland
October 1990-March 1994: PhD Queen's University of Belfast, Supervisors: Elizabeth Hoey, Samuel Martin
October 1986-June1990: University College Dublin, BSc in Industrial Microbiology and Organic Chemistry
 
Research Links:  SBBS Research  |  Biotechnology & Synthetic Biology Research in SBBS 

Professional

               

Education

Year 1994 Institution: Queen's University of Belfast, UK
Qualification: PhD Subject:
         

Publications

Books

Uetz, P. and Titz, B. and Rajagopala, S.V. and Cagney, G. (2010) Experimental methods for protein interaction identification. : Cambridge University Press. [DOI] [Details]
Watson, A. and Cagney, G. (2014) Proteome analysis of chromatin complexes in differentiating stem cells. : Springer New York. [DOI] [Details]
Cagney G, Emili A (2012) Network Biology. New York: Springer. [Details]
 

Edited Books

Cagney G, and Emili A (Ed.). (2011) Network Biology: Methods and Applications (Methods in Molecular Biology). New York London:: Springer. [Details]

Peer Reviewed Journals

English JA, Wynne K, Cagney G, Cotter DR (2013) 'Targeted Proteomics for Validation of Biomarkers in Early Psychosis'. Biological Psychiatry, . [DOI] [Details]
Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cagney G, Cotter DR (2014) 'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia'. Molecular Psychiatry, . [Details]
English JA, Fan Y;F¿¿cking M;Lopez LM;Hryniewiecka M;Wynne K;Dicker P;Matigian N;Cagney G;Mackay-Sim A;Cotter DR (2015) 'Reduced protein synthesis in schizophrenia patient-derived olfactory cells'. Translational psychiatry, 5 . [DOI] [Details]
Topol A, English JA;Flaherty E;Rajarajan P;Hartley BJ;Gupta S;Desland F;Zhu S;Goff T;Friedman L;Rapoport J;Felsenfeld D;Cagney G;Mackay-Sim A;Savas JN;Aronow B;Fang G;Zhang B;Cotter D;Brennand KJ (2015) 'Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients'. Translational psychiatry, 5 . [DOI] [Details]
Munawar N, Olivero G;Jerman E;Doyle B;Streubel G;Wynne K;Bracken A;Cagney G (2015) 'Native gel analysis of macromolecular protein complexes in cultured mammalian cells'. Proteomics, . [DOI] [Details]
English JA, Harauma A, Föcking M, Wynne K, Scaife C, Cagney G, Moriguchi T, Cotter DR (2013) 'Targeted Proteomics for Validation of Biomarkers in Early Psychosis'. Frontiers in genetics, 4 . [Details]
Roguev A, Talbot D, Negri GL, Shales M, Cagney G, Bandyopadhyay S, Panning B, Krogan NJ (2013) 'Quantitative genetic-interaction mapping in mammalian cells'. Nature Methods, 10 (5):432-437. [Details]
Ryan CJ, Krogan NJ., Cunningham P, Cagney, G. (2013) 'All or nothing: protein complexes flip essentiality between distantly related eukaryotes'. Genome Biology and Evolution, . Available Online [DOI] [Details]
Casey WT, Nikodinovic-Runic J, Fonseca Garcia P, Guzik MW, McGrath JW, Quinn JP, Cagney G, Prieto MA, O'Connor KE (2013) 'The effect of polyphosphate kinase gene deletion on polyhydroxyalkanoate accumulation and carbon metabolism in Pseudomonas putida KT2440'. Environmental Microbiology, 5 :740-746. [Details]
Di Cara F, Duca E, Dunbar DR, Cagney G, Heck MM (2013) 'Invadolysin, a conserved lipid-droplet-associated metalloproteinase, is required for mitochondrial function in Drosophila'. Journal of Cell Science, 126 (Pt 20):4769-4781. [DOI] [Details]
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. (2012) 'Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation'. Nature structural & molecular biology, 19 (12):1273-1281. [Details]
Hunkapiller, J,Shen, Y,Diaz, A,Cagney, G,McCleary, D,Ramalho-Santos, M,Krogan, N,Ren, B,Song, JS,Reiter, JF (2012) 'Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal'. PLoS Genetics, 8 . [DOI] [Details]
Ryan, CJ,Roguev, A,Patrick, K,Xu, JW,Jahari, H,Tong, ZT,Beltrao, P,Shales, M,Qu, H,Collins, SR,Kliegman, JI,Jiang, LL,Kuo, D,Tosti, E,Kim, HS,Edelmann, W,Keogh, MC,Greene, D,Tang, C,Cunningham, P,Shokat, KM,Cagney, G,Svensson, JP,Guthrie, C,Espenshade, PJ,Ideker, T,Krogan, NJ (2012) 'Hierarchical Modularity and the Evolution of Genetic Interactomes across Species'. Molecular cell, 46 :691-704. [DOI] [Details]
Jager, S,Cimermancic, P,Gulbahce, N,Johnson, JR,McGovern, KE,Clarke, SC,Shales, M,Mercenne, G,Pache, L,Li, K,Hernandez, H,Jang, GM,Roth, SL,Akiva, E,Marlett, J,Stephens, M,D'Orso, I,Fernandes, J,Fahey, M,Mahon, C,O'Donoghue, AJ,Todorovic, A,Morris, JH,Maltby, DA,Alber, T,Cagney, G,Bushman, FD,Young, JA,Chanda, SK,Sundquist, WI,Kortemme, T,Hernandez, RD,Craik, CS,Burlingame, A,Sali, A,Frankel, AD,Krogan, NJ (2012) 'Global landscape of HIV-human protein complexes'. Nature, 481 :365-370. [DOI] [Details]
Ryan C, Greene D, Guenole A, van Attikum H, Krogan NJ, Cunningham P, Cagney G; (2011) 'Improved functional overview of protein complexes using inferred epistatic relationships'. BMC systems biology, 5 (80). Available Online [DOI] [Details]
Casey, F,Krogan, N,Shields, DC,Cagney, G; (2011) 'Distinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs'. BMC systems biology, 5 . [DOI] [Details]
Wong JW, Cagney G (2010) 'An overview of label-free quantitation methods in proteomics by mass spectrometry'. Methods, 604 :273-283. [DOI] [Details]
Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ (2009) 'Functional organization of the S. cerevisiae phosphorylation network'. Cell, 136 (5):952-963. [DOI] [Details]
Ryan, C,Greene, D,Cagney, G,Cunningham, P; (2010) 'Missing value imputation for epistatic MAPs'. BMC Bioinformatics, 11 . [DOI] [Details]
O'Connor, R,Cryan, LM,Wynne, K,de Stefani, A,Fitzgerald, D,O'Brien, C,Cagney, G; (2010) 'Proteomics Strategy for Identifying Candidate Bioactive Proteins in Complex Mixtures: Application to the Platelet Releasate'. Journal Of Biomedicine And Biotechnology, . [DOI] [Details]
Agbor TA, Cheong A, Comerford KM, Scholz CC, Bruning U, Clarke A, Cummins EP, Cagney G, Taylor CT; (2010) 'Small ubiquitin-related modifier (SUMO)-1 protein modification promotes glycolysis in Hypoxia'. Journal of Biological Chemistry, . [DOI] [Details]
Lenassi, M,Cagney, G,Liao, MF,Vaupotic, T,Bartholomeeusen, K,Cheng, YF,Krogan, NJ,Plemenitas, A,Peterlin, BM; (2010) 'HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4(+) T Cells'. Traffic, 11 :110-122. [DOI] [Details]
Ryan C, Greene D, Cagney G, Cunningham P; (2010) 'Missing value imputation for epistatic MAPs'. BMC Bioinformatics, 11 . [DOI] [Details]
Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL; (2010) 'Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation'. Cell, 6 (2):153-166. [DOI] [Details]
Beltrao P, Cagney G, Krogan NJ; (2010) 'Quantitative genetic interactions reveal biological modularity'. Cell, 141 (5):739-745. [DOI] [Details]
Zheng J, Benschop JJ, Shales M, Kemmeren P, Greenblatt J, Cagney G, Holstege F, Li H, Krogan NJ; (2010) 'Epistatic relationships reveal the functional organization of yeast transcription factors'. Molecular Systems Biology, 6 . [DOI] [Details]
Cagney G, ; (2009) 'Interaction networks: Lessons from large-scale studies in yeast'. Proteomics, 9 (20):4799-4811. [DOI] [Details]
O'Connor KE, Nikodinovic-Runic J, Flanagan M, Hume AR, Cagney G, ; (2009) 'Analysis of the Pseudomonas putida CA-3 proteome during growth on styrene under nitrogen-limiting and non-limiting conditions'. Microbiology (Reading, England), 155 (Pt 10):3348-3361. [DOI] [Details]
Cagney G, Wong JW, McRedmond JP, ; (2009) 'Activity profiling of platelets by chemical proteomics'. Proteomics, 9 (1):40-50. [DOI] [Details]
Fiedler, D,Braberg, H,Mehta, M,Chechik, G,Cagney, G,Mukherjee, P,Silva, AC,Shales, M,Collins, SR,van Wageningen, S,Kemmeren, P,Holstege, FCP,Weissman, JS,Keogh, MC,Koller, D,Shokat, KM,Krogan, NJ; (2009) 'Functional Organization of the S-cerevisiae Phosphorylation Network'. Cell, 136 :952-963. [DOI] [Details]
Wong, JWH,McRedmond, JP,Cagney, G; (2009) 'Activity profiling of platelets by chemical proteomics'. Proteomics, 9 :40-50. [DOI] [Details]
O'Connor KE, Nikodinovic-Runic J, Flanagan M, Hume AR, Cagney G, ; (2009) 'Analysis of the Pseudomonas putida CA-3 proteome during growth on styrene under nitrogen-limiting and non-limiting conditions'. Microbiology (Reading, England), 155 (Pt 10):3348-3361. [DOI] [Details]
Behan, A. T.,Byrne, C.,Dunn, M. J.,Cagney, G.,Cotter, D. R.; (2009) 'Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression'. Mol Psychiatry, 14 (6):601-13. Available Online [Details]
Cotter DR, Behan A, Byrne C, Dunn MJ, Cagney G, ; (2008) 'Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression'. Molecular Psychiatry, (NA). [DOI] [Details]
Wong, J. W. H., Sullivan, M. J., Cagney, G., ; (2008) 'Computational methods for the comparative quantification of proteins in label-free LCn-MS experiments'. Briefings in bioinformatics, 9 (2):156-165. [Details]
O'Riordan A, Johnston O, McMorrow T, Wynne K, Maguire P, Hegarty JE, McCormick A, Watson AJ, Cagney G, Gallagher WM, Ryan MR; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (9):1338-1348. [Details]
Mathivanan, S.,Ahmed, M.,Ahn, N. G.,Alexandre, H.,Amanchy, R.,Andrews, P. C.,Bader, J. S.,Balgley, B. M.,Bantscheff, M.,Bennett, K. L.,Bjorling, E.,Blagoev, B.,Bose, R.,Brahmachari, S. K.,Burlingame, A. S.,Bustelo, X. R.,Cagney, G.,Cantin, G. T.,Cardasis, H. L.,Celis, J. E.,Chaerkady, R.,Chu, F.,Cole, P. A.,Costello, C. E.,Cotter, R. J.,Crockett, D.,DeLany, J. P.,De Marzo, A. M.,DeSouza, L. V.,Deutsch, E. W.,Dransfield, E.,Drewes, G.,Droit, A.,Dunn, M. J.,Elenitoba-Johnson, K.,Ewing, R. M.,Van Eyk, J.,Faca, V.,Falkner, J.,Fang, X.,Fenselau, C.,Figeys, D.,Gagne, P.,Gelfi, C.,Gevaert, K.,Gimble, J. M.,Gnad, F.,Goel, R.,Gromov, P.,Hanash, S. M.,Hancock, W. S.,Harsha, H. C.,Hart, G.,Hays, F.,He, F.,Hebbar, P.,Helsens, K.,Hermeking, H.,Hide, W.,Hjerno, K.,Hochstrasser, D. F.,Hofmann, O.; (2008) 'Human Proteinpedia enables sharing of human protein data'. Nat Biotechnol, 26 (2):164-7. Available Online [Details]
O'Riordan, A,Johnston, O,McMorrow, T,Wynne, K,Maguire, P,Hegarty, JE,McCormick, A,Watson, AJ,Cagney, G,Gallagher, WM,Ryan, MR; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics, 2 :1338-1348. [DOI] [Details]
Casey, FP,Cagney, G,Krogan, NJ,Shields, DC; (2008) 'Optimal stepwise experimental design for pairwise functional interaction studies'. Bioinformatics, 24 :2733-2739. Available Online [DOI] [Details]
Wilmes, GM,Bergkessel, M,Bandyopadhyay, S,Shales, M,Braberg, H,Cagney, G,Collins, SR,Whitworth, GB,Kress, TL,Weissman, JS,Ideker, T,Guthrie, C,Krogan, NJ; (2008) 'A Genetic Interaction Map of RNA-Processing Factors Reveals Links between Sem1/Dss1-Containing Complexes and mRNA Export and Splicing'. Cell, 32 :735-746. [DOI] [Details]
Cotter DR, Behan A, Byrne C, Dunn MJ, Cagney G, ; (2008) 'Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression'. Molecular Psychiatry, . [DOI] [Details]
Cunningham P, Greene D, Cagney G, Krogan N, ; (2008) 'Ensemble Non-negative Matrix Factorization Methods for Clustering Protein-Protein Interactions'. Bioinformatics, . Available Online [DOI] [Details]
Pandey A et al.; (2008) 'Human Proteinpedia enables sharing of human protein data'. Nature Biotechnology, 2 (NA):164-167. [DOI] [Details]
Shields DC, Casey FP, Cagney G, Krogan NJ, ; (2008) 'Optimal stepwise experimental design for pairwise functional interaction studies'. Bioinformatics, (NA). [DOI] [Details]
Cagney, G., McRedmond, J., ; (2008) 'A central resource for platelet proteomics'. Arteriosclerosis, Thrombosis, and Vascular Biology, 28 (7):1214-1215. [Details]
Maderna P, Scannell M, Flanagan MB, deStefani A, Wynne KJ, Cagney G, Godson C, ; (2007) 'Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages'. Immunology, 178 (7):4595-4605. [Details]
Cagney, G., Krogan, N., Weissman, J., Emili, A., Greenblatt, J., ; (2007) 'Insight into cell biology from physical and genetic protein interactions'. Molecular & Cellular Proteomics, 6 (8):19-19. [Details]
Coppinger, JA, OConnor, R, Wynne, K, Flanagan, M, Sullivan, M, Maguire, PB, Fitzgerald, DJ, Cagney, G, ; (2007) 'Moderation of the platelet releasate response by aspirin'. Blood, 109 :4786-4792. [Details]
Wong, JWH, Sullivan, MJ, Cartwright, HM, Cagney, G, ; (2007) 'msmsEval: tandem mass spectral quality assignment for high-throughput proteomics'. BMC Bioinformatics, 8 . [Details]
Cedervall, T,Lynch, I,Foy, M,Berggad, T,Donnelly, SC,Cagney, G,Linse, S,Dawson, KA; (2007) 'Detailed identification of plasma proteins adsorbed on copolymer nanoparticles'. Angewandte Chemie International Edition, 46 :5754-5756. [DOI] [Details]
Cedervall, T.,Lynch, I.,Foy, M.,Berggard, T.,Donnelly, S. C.,Cagney, G.,Linse, S.,Dawson, K. A.; (2007) 'Detailed identification of plasma proteins adsorbed on copolymer nanoparticles'. Angew Chem Int Ed Engl, 46 (30):5754-6. [Details]
Krogan, NJ; Cagney, G; Yu, HY; Zhong, GQ; Guo, XH; Ignatchenko, A; Li, J; Pu, SY; Datta, N; Tikuisis, AP; Punna, T; Peregrin-Alvarez, JM; Shales, M; Zhang, X; Davey, M; Robinson, MD; Paccanaro, A; Bray, JE; Sheung, A; Beattie, B; Richards, DP; Canadien, V; Lalev, A; Mena, F; Wong, P; Starostine, A; Canete, MM; Vlasblom, J; Wu, S; Orsi, C; Collins, SR; Chandran, S; Haw, R; Rilstone, JJ; Gandi, K; Thompson, NJ; Musso, G; St Onge, P; Ghanny, S; Lam, MHY; Butland, G; Altaf-Ui, AM; Kanaya, S; Shilatifard, A; O'Shea, E; Weissman, JS; Ingles, CJ; Hughes, TR; Parkinson, J; Gerstein, M; Wodak, SJ; Emili, A; Greenblatt, JF; ; (2006) 'Global landscape of protein complexes in the yeast Saccharomyces cerevisiae'. NATURE, 440 (7084):637-643. Available Online [Details]
Krogan NJ, Cagney G, Alvaro D, Reid RJ, Thorpe PH, Rothstein R, ; (2006) 'Functional genomics of the yeast DNA-damage response'. Genome Biology, 7 (9). [DOI] [Details]
Griffin, NM; Cagney, G; Sullivan, MJ; Cox, CM; Wynne, K; Fitzgerald, DJ; ; (2006) 'Regulation of protein expression by cyclooxygenase-2 in a human gastric cancer cell line'. Molecular & Cellular Proteomics, 5 (10):39-39. [Details]
Cagney, G., Park, S., Chung, C., Tong, B., O'Dushlaine, C., Shields, D.C., Emili, A.; (2005) 'Human Tissue Profiling with Multidimensional Protein Identification Technology'. J. Proteome Research, . [Details]
Wong, JWH,Cagney, G,Cartwright, HM; (2005) 'SpecAlign - processing and alignment of mass spectra datasets'. Bioinformatics, 21 :2088-2090. [DOI] [Details]
Ghavidel, A; Cagney, G; Emili, A; ; (2005) 'A skeleton of the human protein interactome'. Cell, 122 (6):830-832. [Details]
Cagney, G., Alvaro, D., Reid, R.J., Thorpe, P.H., Rothstein, R., Krogan, N.J.; (2005) 'Functional genomics of the yeast DNA-damage response'. Genome Biology, 7 (9). [Details]
Cagney, G., Park, S., Chung, C., Tong, B., O'Dushlaine, C., Shields, D.C., Emili, A.; (2005) 'Human Tissue Profiling with Multidimensional Protein Identification Technology'. Journal of Proteome Research, . [Details]
Fitzgerald DJ, Maguire PB, Moran N, Cagney G, ; (2004) 'Application of proteomics to the study of platelet regulatory mechanisms'. Trends in Cardiovascular Medicine, 14 (6):207-220. [DOI] [Details]
Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, McGuire PB.; (2004) 'Characterisation of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions'. Blood, 103 (6):2096-2104. [Details]
Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR; (2003) 'A panoramic view of yeast noncoding RNA processing'. Cell, 113 (7):919-933. [Details]
Cagney G, Amiri S, Premawaradena T, Lindo M, Emili A; (2003) 'In silico proteome analysis to facilitate proteomics experiments using mass spectrometry'. Proteome science, 1 (1). [DOI] [Details]
Measday V, Hailey DW, Pot I, Givan SA, Hyland KM, Cagney G, Fields S, Davis TN, Hieter P; (2002) 'Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore'. Gene, 16 (1):101-113. [DOI] [Details]
Cagney G, Emili A; (2002) 'De novo peptide sequencing and quantitative profiling of complex protein mixtures using mass-coded abundance tagging'. Nature Biotechnology, 20 (2):163-170. [DOI] [Details]
Cagney G, Uetz P, Fields S; (2001) 'Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome'. Genomics, 7 (1):27-34. [Details]
Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS, Knight JR, Lockshon D, Narayan V, Srinivasan M, Pochart P, Qureshi-Emili A, Li Y, Godwin B, Conover D, Kalbfleisch T, Vijayadamodar G, Yang M, Johnston M, Fields S, Rothberg JM; (2000) 'A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae'. Nature, 403 (6770):623-627. [DOI] [Details]
Emili AQ, Cagney G; (2000) 'Large-scale functional analysis using peptide or protein arrays'. Nature Biotechnology, 18 (4):393-397. [DOI] [Details]
Lambkin, I., Cagney, G., Kinsella, BT. & O'Mahony, DJ.; (1997) 'Identification of peptide mimetics from phage display libraries which bind to recombinant forms of the human thromboxane A2 receptor'. Journal of Controlled Release, 46 (1-2):190-191. [Details]

Other Journals

Cagney, G., Park, S., Chung, C., Tong, B., O'Dushlaine, C., Shields, D.C., Emili, A.; (2005) 'Human Tissue Profiling with Multidimensional Protein Identification Technology' J. Proteome Research . [Details]

Conference Publications

Maguire, P.B., Foy, M., Cagney, G. Fitzgerald, D.F.; (2005) Using platelet proteomics to identify potential therapeutic targets 11th Erfurt Conference on Platelets jointly with the Lodz Platelet Conference [Details]
   

Editorial

Beltrao, P,Cagney, G,Krogan, NJ; (2010) Quantitative Genetic Interactions Reveal Biological Modularity. Editorial [DOI] [Details]
Cagney, G,McRedmond, J; (2008) A central resource for platelet proteomics. Editorial [DOI] [Details]
Ghavidel, A,Cagney, G,Emili, A; (2005) A skeleton of the human protein interactome. Editorial [Details]
                 

Abstract

Cagney, G,Krogan, N,Weissman, J,Emili, A,Greenblatt, J (2007) Insight into cell biology from physical and genetic protein interactions. Abstract [Details]
McRedmond, J,Sewell, L,Sullivan, M,Edwards, R,Cagney, G (2007) Protein interaction partners of human 14-3-3 protein Isoforms. Abstract [Details]
Griffin, NM,Cagney, G,Sullivan, MJ,Cox, CM,Wynne, K,Fitzgerald, DJ (2006) Regulation of protein expression by cyclooxygenase-2 in a human gastric cancer cell line. Abstract [Details]
McRedmond, JP,O'Donoghue, NM,Sullivan, MJ,Cagney, G (2006) Protein movement during platelet activation revealed using shotgun proteomics of subcellular compartments. Abstract [Details]
       

Reviews

Bushman, FD,Malani, N,Fernandes, J,D'Orso, I,Cagney, G,Diamond, TL,Zhou, HL,Hazuda, DJ,Espeseth, AS,Konig, R,Bandyopadhyay, S,Ideker, T,Goff, SP,Krogan, NJ,Frankel, AD,Young, JAT,Chanda, SK (2009) Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies. Reviews [DOI] [Details]
Cagney, G (2009) Interaction networks: Lessons from large-scale studies in yeast. Reviews [DOI] [Details]
Cagney, G,Alvaro, D,Reid, RJD,Thorpe, PH,Rothstein, R,Krogan, NJ (2006) Functional genomics of the yeast DNA-damage response. Reviews [DOI] [Details]
                                                     

Research

Research Interests

protein interactions
network biology
synthetic biology
bioinformatics
mass spectrometry
 

Recent Postgraduates

Supervision of higher degrees

PhD Manal al-Salami (Year 1) Locus-specific proteomics using CRISPR

PhD Ariane Watson (Year 3) Functional interactions of the Polycomb machines

PhD Giorgio Olivero (Year 3) Protein interactions of the Polycomb Repressive Complexes in stem cells

PhD Gwen Manning (Year 3) Analysis of protein complexes using native mass spectrometry

PhD Gian Luca Negri (2013) Conferring directionality on biological networks (Co-Supervisor Denis Shields)

PhD Colm Ryan (2013) Computational analysis of protein interaction networks (Co-Supervisor Padriag Cunningham)