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Jennifer Mitchell

School of Biomolecular & Biomedical Science
H1.40
Science Centre Hub

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Biography

2013 - Present       Lecturer in Microbiology

2012 - 2013          HRB Fellow in Translational Medicine

2009 - 2012          Lecturer in Infection Biology, University College Dublin

2010 - 2012          Marie Curie Fellow

2004 - 2009          Postdoctoral Fellow, University of California San Francisco

2006                     Postdoctoral Teaching Fellow, San Francisco State University

2004                     Postdoctoral Fellow, University of Dublin, Trinity College          

1999 - 2004          PhD in Microbiology, University of Dublin, Trinity College

1995-1999            BA (Mod) Microbiology, University of Dublin, Trinity College

Research Links: SBBS Research  |  Biotechnology & Synthetic Biology Research in SBBS  |  Infection Biology Research in SBBS  

Professional

 

Associations

Association: American Society for Microbiology , Function/Role: Member
Association: Society for General Microbiology , Function/Role: Member
       

Committees

Committee : UCD Athena SWAN Steering Group
Committee : Society for General Microbiology Prokaryotic Division Committee
Committee : SBBS Demonstrating Committee
Committee : UCD Women in Science Committee
Committee : Dublin Academy of Pathogenomics and Infection Biology Symposium
Committee : UCD Infection Biology Thematic PhD Committee
             

Publications

     

Peer Reviewed Journals

Kathleen Budd, Jennifer Mitchell, Orla Keane (2016) 'Lineage associated expression of virulence traits in bovine-adapted Staphylococcus aureus'. Veterinary Microbiology, 189 :24-31. [DOI] [Details]
Kathleen E. Budd, Finola McCoy, Stefan Monecke, Paul Cormican, Jennifer Mitchell, Orla M. Keane (2015) 'Extensive Genomic Diversity among Bovine-Adapted Staphylococcus aureus: Evidence for a Genomic Rearrangement within CC97'. PLoS ONE, . [Details]
Jennifer Mitchell (2014) 'Go with the flow: S aureus and vascular infection'. Blood, 124 (10):1549-1551. [DOI] [Details]
Jennifer Mitchell; (2011) 'Streptococcus mitis: Walking the line between commensalism and pathogenesis'. Molecular Oral Microbiology, 26 :1-10. [Details]
Nallapareddy, SR,Sillanpaa, J,Mitchell, J,Singh, KV,Chowdhury, SA,Weinstock, GM,Sullam, PM,Murray, BE; (2011) 'Conservation of Ebp-Type Pilus Genes among Enterococci and Demonstration of Their Role in Adherence of Enterococcus faecalis to Human Platelets'. Infection and Immunity, 79 :2911-2920. [DOI] [Details]
Seo H, Xiong YQ, Mitchell J, Seepersaud R, Bayer AS and PM Sullam.; (2010) 'Bacteriophage lysin mediates the binding of Streptococcus mitis to human platelets through interaction with fibrinogen'. PLoS pathogens, 6 (8):e1001047. [Details]
Kwiecinski J, Josefsson E, Mitchell J, Higgins J, Magnusson M, Foster T, Jin T and Bokarewa M. ; (2010) 'Activation of plasminogen by staphylokinase reduces severity of Staphylococcus aureus systemic infection'. Journal of Infectious Diseases, . [Details]
Mitchell J and Sullam P; (2009) 'Streptococcus mitis phage-encoded adhesins mediate attachment to a-2,8-linked sialic acid residues on platelet membrane gangliosides'. Infection and Immunity, 77 (8):3485-3490. [Details]
Mitchell J, Siboo IR, Takamatsu D, Chambers H and Sullam P. Mechanism ; (2007) 'Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB'. Molecular Microbiology, 64 (3):844-857. [Details]
Mitchell J, Tristan A and Foster TJ. ; (2004) 'The fibrinogen binding protein Fbl of Staphylococcus lugdunensis '. Microbiology, 150 (11):3831-3841. [Details]
Jin T, Bokarewa M, Foster T, Mitchell J, Higgins J and Tarkowski A. ; (2004) 'Staphylococcus aureus resists human defensins by production of staphylokinase, a novel bacterial evasion mechanism'. Journal of Immunology, 172 (2):1169-1176. [Details]
 

Conference Publications

Dearbhla Lenehan, Alyson Murray and Jennifer Mitchell. (2014) Identification of Platelet Receptors for E. coli Gordon Research Conference on Hemostasis New Hampshire, [Details]
Joanne Carrig, Jennifer Mitchell (2016) Identification of Platelet Receptors for Streptococcus gallolyticus Microbiology Society Annual Conference , 21-MAR-16 - 24-MAR-16 [Details]
Dearbhla Lenehan, Alyson Murray, Stephen Smith and Jennifer Mitchell (2016) Escherichia coli Platelet Adherence: The Role of LPS and Platelet Receptors Microbiology Society Annual Conference Liverpool, , 21-MAR-16 - 24-MAR-16 [Details]
Alyson Murray, Dearbhla Lenehan, Jennifer Mitchell (2015) The Interaction Of Staphylcoccus aureus With CD36 On Platelets American Society for Microbiology Annual Meeting New Orleans, [Details]
Caoimhe O¿Brien and Jennifer Mitchell (2015) Factors affecting Biofilm Formation in Streptococcus mitis SGM Irish Meeting 2016 Galway, [Details]
Dearbhla Lenehan, Alyson Murray, Jennifer Mitchell (2015) Identification of Platelet Receptors for Escherichia coli American Society for Microbiology Annual Meeting New Orleans, [Details]
C. O'Brien, A. Higgins, D. Lenehan, P. Donovan, S. McCarthy, C. Ward, J. Mitchell (2016) The Role of Fatty Acids in Biofilm Formation by Streptococcus mitis ASM Microbe Conference Boston, , 16-JUN-16 - 20-JUN-16 [Details]
Alyson Murray and Jennifer Mitchell (2013) The Human Platelet membrane receptor CD36 - A receptor for Streptococcus and Staphylococcus Lipoteichoic acid Cold Spring Harbour Laboratory Microbial Pathogenesis & Host Response meeting , 17-SEP-13 - 21-SEP-13 [Details]
Alyson Murray and Jennifer Mitchell (2013) Bacterial Lipoteichoic acid interacts with the Human Platelet Membrane receptor CD36 Society for General Microbiology Autumn Meeting 2013 , 02-SEP-13 - 04-SEP-13 [Details]
Alyson Murray and Jennifer Mitchell1 (2013) The Human Platelet membrane receptor CD36 - A receptor for Streptococcus and Staphylococcus Lipoteichoic acid StaphGBI 2013 , 05-SEP-13 - 06-SEP-13 [Details]
Alyson Murray and Jennifer Mitchell (2013) Bacterial Lipoteichoic acid interacts with the Human Platelet Membrane receptor CD36 Society for General Microbiology Irish Division Meeting Spring 2013 , 21-MAR-13 - 22-MAR-13 [Details]
Murray A and Mitchell J. (2012) Characterization of the Interaction of bacterial lipoteichoic acid with the Human Membrane receptor CD36 on the surface of platelets American Society for Microbiology 112th General Meeting, San Francisco , 16-JUN-12 - 19-JUN-12 [Details]
Jennifer Mitchell (2012) CD36 is a Platelet Receptor for Bacterial Pathogens International Cardiovascular Infection Symposium, Society for General Microbiology Spring Conference [Details]
A Murray and J Mitchell; (2011) Characterization of the Interaction of Staphylococcus aureus with the Human Membrane receptor CD36 on the surface of platelets Staph GBI (Great Britain & Ireland) 2011 Conference [Details]
Mitchell J. (2011) The role of CD36 as a platelet receptor for Gram Positive Pathogens Young Life Scientists Ireland Symposium, UCD Dublin [Details]
Budd KE, McCoy F, Flynn J, Mitchell J and Keane OM. (2011) Genotypic characterization of Staphylococcus aureus strains associated with clinical mastitis on Irish dairy herds 4th International Symposium on Animal Functional Genomics, Dublin [Details]
Murray A and Mitchell J; (2011) CD36 is a receptor for the adherence of Gram positive pathogens to platelets 6th International Conference on Gram-positive Microorganisms, Italy [Details]
Mitchell J and Sullam P. ; (2009) Streptococcus mitis phage-encoded adhesins mediate attachment to 2-8 linked sialic acid residues on platelet membrane gangliosides 5th International Conference on Gram-positive Microorganisms San Diego, [Details]
Mitchell J and Sullam P. ; (2008) Streptococcus mitis adheres to sialylated residues on human platelets Society for General Microbiology 163rd Meeting [Details]
Mitchell J, Siboo IR, Takamatsu D, Chambers H and Sullam P. ; (2007) Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB Bay Area Microbial Pathogenesis Symposium [Details]
Mitchell J, Siboo IR and Sullam P. ; (2007) The Streptococcus mitis Platelet Binding Adhesins PblA and PblB are Anchored to the Cell Surface via Choline Binding Domains American Society for Microbiology. 107th General Meeting Toronto, [Details]
Mitchell J, Siboo IR, Takamatsu D, and Sullam P. ; (2006) Bacterial Altruism or the Selfish Phage: A lysis-reuptake mechanism for the cell surface expression of the S. mitis platelet binding proteins PblA and PblB Cold Spring Harbor Laboratory Meeting, Molecular Genetics of Bacteria and Phages [Details]
Mitchell J, Siboo IR, Takamatsu D, and Sullam P. Bacterial ; (2006) Bacterial Altruism: A lysis-reuptake mechanism for the cell surface expression of the S. mitis platelet binding proteins PblA and PblB ASM Symposium on Streptococcal Genetics Saint Malo, France, [Details]
Mitchell J, Siboo IR, Takamatsu D, Sullam P. ; (2005) A lysis-reuptake mechanism for the cell surface expression of the S. mitis platelet binding proteins PblA and PblB Cold Spring Harbor Laboratory Meeting, Microbial Pathogenesis and Host Response [Details]
                                 

Reviews

Mitchell, J (2011) Streptococcus mitis: walking the line between commensalism and pathogenesis. Reviews [DOI] [Details]
                                                     

Research

Research Interests

Current research in my lab is concerned with analysing the interaction of commensal and pathogenic streptococci and staphylococci with glycoproteins and glycolipids on the surface of host cells. Analysis of this interaction will help us to understand how these bacteria make the transition from a commensal to a pathogenic state.

Research Projects

Sponsor : Teagasc
Title : Molecular characterization of adhesin-receptor interactions in bovine-adapted Staphylococcus aureus
Start Date / End Date : 01-SEP-16 / 31-AUG-20
Sponsor : The Wellcome Trust (WT)
Title : The role of phage proteins in S. mitis attachment to oral and respiratory epithelial cells
Start Date / End Date : 13-JUL-15 / 04-SEP-15
Sponsor : Society for General Microbiology
Title : The role of autolysis in biofilm formation by Streptococcus mitis
Start Date / End Date : 08-JUN-15 / 31-JUL-15
Sponsor : University College Dublin (UCD)
Title : Development of a peptide based inhibitor of bacterial platelet interactions in Sepsis
Start Date / End Date : 01-APR-14 / 30-SEP-15
Sponsor : Society for General Microbiology
Title : SGM Harry Smith Vacation Studentship 2014 VS14/86
Start Date / End Date : 01-JUN-14 / 31-AUG-14
Sponsor : Enterprise Ireland (EI)
Title : Enterprise Ireland Application for Proposal Preparation Support for Co-ordinator (ERC)
Start Date / End Date : 10-JAN-13 / 21-FEB-13
Sponsor : University College Dublin (UCD)
Title : M.Sc. Biotechnology research supervision
Start Date / End Date : 06-MAY-11 / 07-MAY-12
Sponsor : Health Research Board (HRB)
Title : Developing Inhibitors of Mucosal Colonisation by Gram Positive Pathogens
Start Date / End Date : 01-AUG-12 / 31-JUL-13
Sponsor : EC Framework (FP7)
Title : The role of glycoprotein CD36 as a platelet receptor for Streptococci and Staphylococci (MITISCD36LTA)
Start Date / End Date : 01-SEP-10 / 31-AUG-12
Sponsor : Teagasc
Title : Genetic and Molecular Mechanisms of Pathogenesis in mastitis-causing Staphylococcus aureus
Start Date / End Date : 01-OCT-10 / 30-SEP-14
Sponsor : University College Dublin (UCD)
Title : Glycoprotein CD36 (GPIV) is a Platelet Receptor for Streptococcus mitis Lipoteichoic Acid.
Start Date / End Date : 17-MAY-10 / 16-NOV-11
Sponsor : University College Dublin (UCD)
Title : The interaction of Streptococcus mitis with CD36
Start Date / End Date : 01-SEP-09 / 31-AUG-12

Recent Postgraduates

Alyson Murray PhD
Kathleen Budd PhD

Current Postgraduate Students

Dearbhla Lenehan, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

Teaching Philosophy

VET20180: Introduction to One Health

VET40080: Advances in Infection Biology

VET40100: Current Concepts in Infection Biology B

VET40090: Current Concepts in Infection Biology A

VET30030: Introduction to Veterinary Microbiology

MICR40010: Recombinant DNA Technology

Modules Coordinated

201500   MICR40100     Microbiology: Emerging Issues in Biotech
201500   MICR30070     Microbiology: Skills in Microbiology
201500   VET40090     Veterinary Medicine: Concepts Infection Biology A
201500   MICR40150     Microbiology: Host Pathogen Interaction
       

Collaborators

Internal Collaborators

Dr. Stephen Gordon

Dr. Marguerite Clyne

External Collaborators

Dr. Paul Sullam, University of California San Francisco

Dr. James Smyth, University of California San Francisco

Dr. Samy Lamouille, University of California San Francisco

Dr. Orla Keane, Teagasc

Dr. Lynda Fenelon, St. Vincents University Hospital

Dr. James O'Gara, NUIG