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Kevin O'Connor

Senior Lecturer

School Of Biomolecular & Biomed Science
Ardmore House
Belfield
Dublin 4

Tel: +353 1 7161307
Email: kevin.oconnor@ucd.ie

Biography

2006- present Senior College Lecturer, UCD
2001- 2006
College Lecturer Microbiology, UCD
1999 -2001 Assistant College lecturer, Microbiology, UCD
1997 - 1999 Postdoctoral fellowship, ETH Zurich, Switzerland
1996 - 1997 Postdoctoral fellowship, Wageningen, NL
1996 Ph.D. Microbiology, NUI.
1996 Research project, Bilthoven, NL

Biodegradable plastic, Green technology, Polyhydroxyalkanoate , Plastic recycling, Upcycling, Waste transformation, Biocatalysis, Enzyme technology, Protein engineering, Directed evolution, Microbiology, Oxidoreductase, UCD Conway Institute, Centre for Synthesis and Chemical Biology (CSCB), Technology centre for Biorefining and Bioenergy (TCBB), Bioplastech ltd. (UCD spin out company)

Professional

 

Associations

Association: Society for General Microbiology, Function/Role: To promote microbiology on the Island of Ireland
Association: American society for Microbiology, Function/Role: Promoting microbiology and co-operation among microbiologists
     

Conference Contributions

Ward P.G. and O' Connor K.E.; (2004) Polyhydroxyalkanoate synthesis from aromatic hydrocarbons. [Poster Presentation], European Symposium on Biopolymers ESBP04 Tailored biopolymers adn their applications innindustry and medicine, St Gallen Switzerland , 12-MAY-04 - 14-MAY-04.
Tobin K. and O' Connor K. E.; (2004) Biopolymer accumulation by Pseudomonads from aromatic substrates. [Poster Presentation], European Symposium on Biopolymers ESBP04 Tailored biopolymers adn their applications innindustry and medicine, St Gallen, Switzerland , 12-MAY-04 - 14-MAY-04.
Helen Dunn, Tracy Curtin, Patrick Coen and Kevin O' Connor. ; (2003) Alkene Biotransformation by Whole Cells Expressing Styrene Monooxygenase. [Poster Presentation], Conway Festival of Research 2003,, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland , 10-SEP-03 - 11-SEP-03.
Meabh ORiordan, Helen Dunn, Patricia M.Kieran, Dermot M. Malone, and Kevin E. OConnor,; (2003) Investigation of factors influencing the growth of Pseudomonas putida CA-3 and the induction of styrene monooxygenase, . [Poster Presentation], Conway Festival of Research, Conway Institute of Biomolecular and Biomedical Research, University College dublin , 10-SEP-03 - 11-SEP-03.
O' Connor, Kevin E.; (2003) Polyhydroxyalkanoate accumulation by Pseudomonas putida CA-3. [Invited Oral Presentation], Biocatalysis and Biodegradation, Society for General Microbiology, Irish Branch meeting, University College Dublin , 04-SEP-03 - 05-SEP-03.
O' Connor, Kevin E.; (2003) [Conference Organising Committee Chairperson], Biocatlaysis and Biodegradation, Society for General Microbiology, Irish Brnach symposium, University College Dublin , 04-SEP-03 - 05-SEP-03.
Brooks, S. J, Doyle, E. M, Li, Z and OConnor, K. E.; (2003) Halophenol transformation by cell free extracts of Pseudomonas putida F6. [Poster Presentation], Proceedings of the Environmental Protection Agency Pathways to a sustainable future, EPA headquarters, University College Dublin , 15-JUN-03 - 15-JUN-03.
Brooks, S. J, Doyle, E. M, Li, Z and OConnor, K. E. ; (2003) Substrate range of a phenol oxidase enzyme from Pseudomonas putida F6. . [Poster Presentation], Biocatalysis and Biodegradation, University College Dublin , 04-SEP-03 - 05-SEP-03.
Aoife Mc Mahon, Evelyn Doyle and Kevin E. OConnor; (2003) Biochemical Characterisation of a phenol oxidase from Pseudomonas putida F6. . [Poster Presentation], Pathways to Sustainable Development, Environmental Protection Agency , The Royal Hospital Kilmainham, Dublin, Ireland , 15-JUN-03 - 16-JUN-03.
Helen Dunn, Tracy Curtin, Patrick Coen and Kevin O' Connor,; (2003) Alkene Biotransformation by Whole Cells Expressing Styrene Monooxygenase, . [Poster Presentation], Biocatalysis and Biodegradation, The Society for General Microbiology (Irish Branch Symposium), University College Dublin, Ireland , 04-SEP-03 - 05-SEP-03.
Nolan L. and O Connor K. E.; (2003) Phenol oxidase induction in Pseudomonas putida F6. [Poster Presentation], Biocatalysis and Biodegradation Society for General Microbiology (autumn symposium), University College Dublin , 04-SEP-03 - 05-SEP-03.
P.G. Ward, K.E. O'Connor; (2003) Biosynthesis of Aromatic Polyesters by Pseudomonas putida CA-3. [N/A], Biocatalysis and Biodegradation Society for General Microbiology , University College Dublin , 04-SEP-03 - 05-SEP-03.
P.G. Ward, G. De Roo, K.E. O'Connor; (2002) Biochemical characterisation of the n-alkanoic and n- phenylalkanoic degradative pathway in Pseudomonas CA-3. [Oral Presentation], Metals, Microbes and the Environment Society for General Microbiology , Carlow Institute of technology, Carlow, Ireland , 26-MAR-02 - 27-MAR-02.
Brooks, S. J, Doyle, E. M, Duetz, W. and OConnor, K. E. ; (2002) Halophenol transformation by Pseudomonas putida F6. . [Oral Presentation], Proceedings of the Society for General Microbiology Irish Branch Symposium on Sensing and Signalling in Microbial Populations, Dublin City University, Dublin, Ireland. , 05-SEP-02 - 06-SEP-02.
Tobin, K., and OConnor, K.; (2002) Production of PHA by Pseudomonas fluorescens CA-4 . [Poster Presentation], Sensing and Signalling in Microbial Populations Society for General Microbiology, Irish Branch Symposium , School of Biotechnology, Dublin City University, Ireland , 05-SEP-02 - 06-SEP-02.
Aoife Mc Mahon, Evelyn Doyle, Sarah Brooks and Kevin E. OConnor ; (2002) Biochemical Characterisation of a phenol oxidase from Pseudomonas putida F6. [Poster Presentation], Society for General Microbiology, Irish meeting, Dublin City University, Dublin Ireland , 05-SEP-02 - 06-SEP-02.
Nolan L. and O Connor K. E; (2002) Biochemical and physiological characterisation of Pseudomonas putida F6. [Poster Presentation], Sensing and signalling in microbial populations Society for General Microbiology (autumn symposium), Dublin City University , 05-SEP-02 - 06-SEP-02.
P.G. Ward, G. De Roo, K.E. O'Connor ; (2002) PHA production by Pseudomonas putida CA-3. [Poster Presentation], The world of microbes International Union of Microbiological Societies (I.U.M.S.) , Le Palais des Congres de Paris, France , 27-JUL-02 - 01-AUG-02.

Committees

Committee : (SGM) Society for general Microbiology, Irish Branch
             

Publications

 

Book Chapters

O'Connor, K.E. and A.D.W. Dobson.; (1997) 'Microbial degradation of Alkenylbenzenes. ' In: D. Sheehan and J. walker (eds). Bioremediation protocols, Humana Press Inc., Totowa, New Jersey. [Details]
 

Peer Reviewed Journals

O'Connor S, Szwej E, Nikodinovic-Runic J, O'Connor A, Byrne AT, Devocelle M, O'Donovan N, Gallagher WM, Babu R, Kenny ST, Zinn M, Zulian QR, O'Connor KE (2013) 'The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate'. Biomaterials, 34 (11):2710-2718. [Details]
Brooks SJ, Nikodinovic J, Martin L, Doyle EM, O'Sullivan T, Guiry PJ, Coulombel L, Li Z, O'Connor KE. (2013) 'Production of a chiral alcohol, 1-(3,4-dihydroxyphenyl) ethanol, by mushroom tyrosinase'. Biotechnology Letters, 35 (5):779-783. [DOI] [Details]
Babu RP, O'Connor K, Seeram R. (2013) 'Current progress on bio-based polymers and their future trends'. Progress in Biomaterials, 2 (8). [DOI] [Details]
Molloy S, Nikodinovic-Runic J, Martin LB, Hartmann H, Solano F, Decker H, O'Connor KE. (2013) 'Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches'. Biotechnology and Bioengineering, 110 (7):1848-1857. [DOI] [Details]
Nikodinovic-Runic J, Coulombel L, Francuski D, Sharma ND, Boyd DR, More O'Ferrall R and O'Connor KE (2012) 'The oxidation of alkylaryl sulfides and benzo[b]thiophenes by Escherichia coli cells expressing wild-type and engineered styrene monooxygenase from Pseudomonas putida CA-3'. Applied Microbiology and Biotechnology, . [DOI] [Details]
Narancic T, Kenny S, Lidija D, Vasiljevic B, O'Connor KE, Nikodinovic-Runic J (2012) 'Medium chain length polyhydroxyalkanoate production by newly isolated Pseudomonas sp. TN301 from a wide range of poly- and monoaromatic hydrocarbons'. Journal of Applied Microbiology, 113 :508-520. [Details]
Kenny ST, Nikodinovic Runic J, Kaminsky W, Woods T, Babu RP, and O'Connor KE. (2012) 'Development of a bioprocess to convert PET derived terephthalic acid and biodiesel derived glycerol to medium chain length polyhydroxyalkanoate'. Applied Microbiology and Biotechnology, 95 (3):623-633. [DOI] [Details]
Narancic T, Nikodinovic J, Kenny S, Vasiljevic B and K O'Connor. (2012) 'Metabolic versatility of Gram-positive microbial isolates from contaminated river sediments'. Journal of Hazardous Materials, 215-216 :243-251. [Details]
Boyd DR, Sharma ND, McMurray B, Haughey SA, Allen CCR,Hamilton JTG, McRoberts WC,More O'Ferrall RA, Nikodinovic-Runic J, Coulombel LA and O'Connor KE. (2012) 'Bacterial dioxygenase- and monooxygenase-catalysed sulfoxidation of benzo[b]thiophenes'. Org Biomol Chem, 10 :782-790. [Details]
Nikodinovic-Runic, J, Casey, E, Duane, G.F., Mitic, D., Hume, A.R., Kenny, S.T., O'Connor, K.E., ; (2011) 'Process analysis of the conversion of styrene to biomass and medium chain length polyhydroxyalkanoate (mcl-PHA) in a two-phase bioreactor'. Biotechnology and Bioengineering, . Available Online [Details]
Coulumbel, L., Nolan, L.C., Nikodinovic, J., Doyle, E.M. and O'Connor, K.E.; (2011) 'Biotransformation of 4-halophenols to 4-halocatechols using Escherichia coli expressing 4-hydroxyphenylacetate 3-hydroxylase'. Applied Microbiology and Biotechnology, 89 (6):1867-1875. [DOI] [Details]
Goff, M,Nikodinovic-Runic, J,O'Connor, KE; (2009) 'Characterization of temperature-sensitive and lipopolysaccharide overproducing transposon mutants of Pseudomonas putida CA-3 affected in PHA accumulation'. FEMS MICROBIOL LETT, 292 (NA):297-305. [DOI] [Details]
Gursky L, Nikodinovic-Runic J, Feenstra KA, OConnor KE.; (2009) 'In vitro evolution of styrene monooxygenase from Pseudomonas putida CA-3 for improved epoxide synthesis'. Applied Microbiology and Biotechnology, . [Details]
Zhang, W,O'Connor, K,Wang, DIC,Li, Z; (2009) 'Bioreduction with Efficient Recycling of NADPH by Coupled Permeabilized Microorganisms'. APPL ENVIRON MICROB, 75 :687-694. [DOI] [Details]
O'Connor KE, Nikodinovic J, Kenny ST, Babu RP, Woods T, Blau WJ, ; (2008) 'The conversion of BTEX compounds by single and defined mixed cultures to medium-chain-length polyhydroxyalkanoate'. Applied microbiology and biotechnology, 4 (NA):665-673. [DOI] [Details]
Nikodinovic, J,Kenny, ST,Babu, RP,Woods, T,Blau, WJ,O'Connor, KE; (2008) 'The conversion of BTEX compounds by single and defined mixed cultures to medium-chain-length polyhydroxyalkanoate'. Applied Microbiology and Biotechnology, 80 (NA):665-673. [DOI] [Details]
Kenny, S. T., Nikodinovic-Runic, J., Kaminsky, W., Woods, T., Babu, R. P., Keely, C. M., Blau, W. & O¿Connor, K. E.; (2008) 'Up-cycling of PET (Polyethylene terephthalate) to the biodegradable plastic PHA (Polyhydroxyalkanoate)'. Environmental Science and Technology, . [Details]
Martin, L. B., Nikodinovic, J., Mc Mahon, A. M., Vijgenboom, E. & O'Connor, K. E.; (2008) 'Assessing the catalytic activity of three different sources of tyrosinase: A study of the oxidation of mono- and difluorinated monophenols'. Enzyme and Microbial Technology, 43 :297-301. [Details]
Martin, L. B., Nikodinovic, J., Mc Mahon, A. M., Vijgenboom, E. & O'Connor, K. E.; (2008) 'Assessing the catalytic activity of three different sources of tyrosinase: A study of the oxidation of mono- and difluorinated monophenols'. Enzyme and Microbial Technology, 43 :297-301. [Details]
Tobin, KM; O'Leary, ND; Dobson, ADW; O'Connor, KE; ; (2007) 'Effect of heterologous expression of phaG [(R)-3-hydroxyacyl-ACP-CoA transferase] on polyhydroxyalkanoate accumulation from the aromatic hydrocarbon phenylacetic acid in Pseudomonas species'. Fems Microbiology Letters, 268 (1):9-15. [Details]
Goff M., Patrick G. Ward and Kevin E. O'Connor; (2007) 'Improvement of the conversion of polystyrene to polyhydroxyalkanoate through the manipulation of the microbial aspect of the process: A nitrogen feeding strategy for bacterial cells in a stirred tank reactor'. Journal of Biotechnology, . [Details]
Tobin K. M. , John W. McGrath, Alan Mullan and Kevin E. O' Connor; (2007) 'Polyphosphate accumulation by Pseudomonas putida CA-3 and other medium chain length polyhydroxyalkanoate accumulating bacteria under aerobic growth conditions'. Applied Environmental Microbiology, 73 :1383-1387. [Details]
McMahon A. E.M. Doyle and K. E. O'Connor; (2007) 'Biochemical characterisation of the coexisting tyrosinase and laccase in the soil bacterium Pseudomonas putida F6'. Enzyme and Microbial Technology, 40 :1435-1441. [Details]
Nolan L and K..E. O' Connor; (2007) 'Use of bacterial cells expressing toluene-4-monooxygenase and cell free tyrosinase for the synthesis of 4-fluorocatechol from fluorobenzene'. Biotechnology Letters, 29 :1045-1050. [Details]
Mc Mahon A.M., Doyle, E.M., Brooks, S.J. and O'Connor, K.; (2007) 'Purification and characterisation of tyrosinase and laccase from Pseudomonas putida F6'. ENZYME AND MICROBIAL TECHNOLOGY, 40 :1435-1441. [Details]
Ward, PG; Goff, M; Donner, M; Kaminsky, W; O'Connor, KE; ; (2006) 'A two step chemo-biotechnological conversion of polystyrene to a biodegradable thermoplastic'. Environmental Science and Technology, 40 (7):2433-2437. [Details]
Brooks, S.J., Doyle, E.M. and O' Connor, K. E.; (2006) 'Tyrosol to hydroxytyrosol biotransformation by immobilised cell extracts of Pseudomonas putida F6'. ENZYME AND MICROBIAL TECHNOLOGY, 39 (2):191-196. [Details]
O'Connor KE, Mooney A, Ward PG, ; (2006) 'Microbial degradation of styrene: biochemistry, molecular genetics, and perspectives for biotechnological applications'. Applied Microbiology and Biotechnology, 1 (NA):1-10. [DOI] [Details]
Kevin E. O' Connor, Niall, P O Leary, Julian R. Marchesi, Alan D. W. Dobson & Wouter Duetz.; (2005) 'Isolation and characterization of a diverse group of phenylacetic acid degrading microorganisms from pristine soil'. Chemosphere, IN PRESS . [Details]
Ward, Patrick G. , de Roo, Guy, and O' Connor Kevin E. ; (2005) 'Polyhydroxyalkanoate accumulation from styrene and phenylacetic acid by Pseudomonas putida CA-3. '. Applied and Environmental Microbiology, 70 ((4)):2046-2052. [Details]
Niall D. O Leary, Kevin E. O Connor Patrick Ward, Miriam Goff and Alan D. W. Dobson.; (2005) 'Genetic characterisation of polyhydroxyalkanoate accumulation from styrene in P. putida CA-3'. Applied and Environmental Microbiology, IN PRESS . [Details]
Nolan, LC; O'Connor, KE; ; (2005) 'A spectrophotometric method for the quantification of an enzyme activity producing 4-substituted phenols: Determination of toluene-4-monooxygenase activity'. Analytical Biochemistry, 344 (2):224-231. [Details]
Tobin, KM; O'Connor, KE; ; (2005) 'Polyhydroxyalkanoate accumulating diversity of Pseudomonas species utilising aromatic hydrocarbons'. Fems Microbiology Letters, 253 (1):111-118. [Details]
McMahon, AM; Doyle, EM; O'Connor, KE; ; (2005) 'Detection and quantification of 4-substituted phenols: a comparison of mushroom tyrosinase and cell extracts of Pseudomonas putida F6'. Enzyme and Microbial Technology, 36 (5-6):808-812. [Details]
Mc Mahon, A.M., Doyle, E.M. and O'Connor, K.E.; (2005) 'Detection and quantification of 4-substituted phenols: a comparison of mushroom tyrosinase and cell extracts of Pseudomonas putida F6'. ENZYME AND MICROBIAL TECHNOLOGY, 36 :808-812. [Details]
Dunn, HD; Curtin, T; O'Riordan, MA; Coen, P; Kieran, PM; Malone, DM; O'Connor, KE; ; (2005) 'Aromatic and aliphatic hydrocarbon consumption and transformation by the styrene degrading strain Pseudomonas putida CA-3'. FEMS MICROBIOLOGY LETTERS, 249 (2):267-273. [Details]
O'Connor, KE, O'Leary, NP, Marchesi, JR, Dobson, ADW, Duetz, W, ; (2005) 'Isolation and characterization of a diverse group of phenylacetic acid degrading microorganisms from pristine soil'. Chemosphere, 61 (7):965-973. [Details]
Ward, PG; O'Connor, KE; ; (2005) 'Induction and quantification of phenylacyl-CoA ligase enzyme activities in Pseudomonas putida CA-3 grown on aromatic carboxylic acids'. Fems Microbiology Letters, 251 (2):227-232. [Details]
Dunn, HD; Curtin, T; O'Riordan, MA; Coen, P; Kieran, PM; Malone, DM; O'Connor, KE; ; (2005) 'Aromatic and aliphatic hydrocarbon consumption and transformation by the styrene degrading strain Pseudomonas putida CA-3'. FEMS Microbiol Letters, 249 (2):267-273. [Details]
Ward, PG; O'Connor, KE; ; (2005) 'Bacterial synthesis of polyhydroxyalkanoates containing aromatic and aliphatic monomers by Pseudomonas putida CA-3'. International Journal of Biological Macromolecules, 35 (3-4):127-133. [Details]
Ward, PG; de Roo, G; O'Connor, KE; ; (2005) 'Accumulation of polyhydroxyalkanoate from styrene and phenylacetic acid by Pseudomonas putida CA-3'. Applied and Environmental Microbiology, 71 (4):2046-2052. [Details]
Brooks, SJ; Doyle, EM; Hewage, C; Malthouse, JPG; Duetz, W; O'Connor, KE; ; (2004) 'Biotransformation of halophenols using crude cell extracts of Pseudomonas putida F6'. Applied Microbiology and Biotechnology, 64 (4):486-492. [Details]
O'Leary, ND; Duetz, WA; Dobson, ADW; O'Connor, KE; ; (2002) 'Induction and repression of the sty operon in Pseudomonas putida CA-3 during growth on phenylacetic acid under organic and inorganic nutrient-limiting continuous culture conditions'. Fems Microbiology Letters, 208 (2):263-268. [Details]
O'Leary, ND; O'Connor, KE; Dobson, ADW; ; (2002) 'Biochemistry, genetics and physiology of microbial styrene degradation'. Fems Microbiology Reviews, 26 (4):403-417. [Details]
O' Leary, N, O' Connor K. E., W. Duetz, and A.D.W. Dobson.; (2001) 'Transcriptional regulation of styrene degradation in Pseudomonas putida CA-3'. Microbiology, 147 :973-979. [Details]
O'Connor, K.E., B. Witholt and W. Duetz.; (2001) 'p-Hydroxyphenylacetic acid metabolism in Pseudomonas putida F6'. Journal of Bacteriology, 183 :928-933. [Details]
Duetz, W. A., L. Ruedi R. Hermann, K. E. O' Connor, J. Buchs and B. Witholt. .; (2000) 'Methods for intense aeration, growth, storage, and replication of bacterial strains in microtitre plates'. Applied and Environmental Microbiology, 66 :2641-2646. [Details]
O'Connor K.E., and S. Hartmans.; (1998) 'Indigo formation by aromatic hydrocarbon-degrading bacteria'. Biotechnology Letters, 20 (3):219-223. [Details]
O'Connor K.E., A.D.W., Dobson, and S. Hartmans; (1997) 'Indigo formation by microorganisms expressing styrene monooxygenase activity. Appl. Environ. Microbiol'. Applied and Environmental Microbiology, 63 :4287-4291. [Details]
O'Connor, K.E. W. Duetz, B. Wind, and A.D.W. Dobson.; (1996) 'Catabolite repression and the effects of carbon, ammonium and sulphate limitation on styrene metabolism in P. putida CA-3 grown in continuous culture'. Applied and Environmental Microbiology, 62 :3594-3599. [Details]
O'Connor, K.E., and A.D.W. Dobson.; (1996) 'Microbial degradation of alkenylbenzenes'. World Journal of Microbiology & Biotechnology, 12 :207-212. [Details]
O'Connor, K., C.M. Buckley, S. Hartmans, and A.D.W. Dobson.; (1995) 'Possible regulatory role for non-aromatic carbon sources in styrene degradation by Pseudomonas putida CA-3'. Applied Microbiology and Biotechnology, 61 :544-548. [Details]
Corkery, D.M., K.E. O'Connor, C.M. Buckley, and A.D.W. Dobson.; (1994) 'Ethylbenzene degradation by Pseudomonas fluorescens strain CA-4'. Fems Microbiology Letters, 124 :23-27. [Details]
 

Conference Publications

Guzik M, Duane G, Kenny S, Casey E, O'Connor K (2011) Mathematical modelling of the bioprocess for PHA production European Congress of Applied Biotechnology Berlin, , 25-SEP-11 - 29-SEP-11 [Details]
Nolan, L.C., Gibson, P., Doyle, E.M. and O'Connor, K.E. ; (2007) Biotransformation of halogenated benzenes by Pseudomonas mendocina KR1 Proceedings of the Society for General Microbiology, Irish Branch Symposium Queens University Belfast, , 30-AUG-07 - 31-AUG-07 , pp.28-28 [Details]
O' Connor, K.E., and P. Ward (2006) A combination of Chemistry and Microbiology for the conversion of polystyrene to a biodegradable plastic International Symposium on Biopolymers (ISBP) [Details]
Aoife Mc Mahon, Evelyn Doyle and Kevin E. OConnor ; (2003) Development of Bacterial Phenol Oxidase as a Biosensor Biocatalysis And Biodegradation, Society for General Microbiology, Irish meeting, University College Dublin, Ireland, , 04-SEP-03 - 05-SEP-03 , pp.20-20 [Details]
Ward P., G. De Roo, K. O' Connor; (2002) PHA production by Pseudomonas putida CA-3 Proceedings of the Xth International Congress of Bacteriology and Applied Microbiology. The world of Microbes. 2002 Paris, , 27-JUL-02 - 01-AUG-02 [Details]
Brooks S., E.M. Doyle, K.E. O' Connor; (2002) Biotransformation of halophenols by Pseudomonas putida F6 phenol oxidase Xth International Congress of Bacteriology and Applied Microbiology. The world of Microbes. 2002 Paris, , 27-JUL-02 - 01-AUG-02 [Details]
Brooks S., E.M. Doyle, W. Duetz, K.E. O' Connor; (2001) Characterization of a phenol oxidase from Pseudomonas putida F6 Proceedings American Society for Microbiology and Society of General Microbiology. Biodegradation, Biotransformation and Biocatalysis (B3), 2001 San Juan Puerto Rico, , 02-OCT-01 - 06-OCT-01 [Details]

Published Reports

Kenny S.T., Nikodinovic, J.N. and O Connor K E. 2011. (2011) The Conversion of Waste PET Plastic into a High Value-Added Biodegradable Plastic. Enironmental Protection Agency Ireland (EPA) Strive report Series, Ireland. [Details]
                                                                                       

Research

Research Interests

I lead a research group investigating biocatalysis and metabolic engineering. We focus on two major areas 1) biodegradable polymer synthesis by bacteria and 2) Enzymes as biocatalysts in the transformation of aromatic and aliphatic substrates.

Biodegradable polymer synthesis
we have seen a growing interest in the manufacturing of materials that are sustainable and biodegradable. Our research group is investigating the ability of bacteria to synthesise biodegradable polymers with biotechnological potential, namely polyhydroxyalkanoates (PHAs). Our research focuses on the conversion of waste materials to this type of biodegradable plastic using bacteria.

Enzymes as biocatalysts

Biological catalysts can offer certain advantages over traditional chemical catalysts through their high regiospecificity and sterospecificity. In addition they perform catalysis under mild conditions. We are investigating the ability of enzymes as cell free crude enzyme preparations, purified enzyme preparations and whole cells expressing enzymes as biocatalysts for the synthesis of small molecules which have uses as drugs, drug synthons, and fine chemicals.  we use protein engineering as a means to alter activity so we can investigate the effect of changes in proteins at the molecular level and design better biocatalysts.


     

Collaborators

Internal Collaborators

Professor William Gallagher, SBBS - Cancer biology

Dr Gerard Cagney - SBBS - Proteomics

Professor Patrick Guiry

 

 

External Collaborators

Dr Ramesh Babu
 
Physics Departent and Materials Centre TCD - Biodegradable polymers

Dr Marc Devocelle
Royal College of Surgeons - Chemistry - organic synthesis

Professor Derek Boyd,
Questor centre, Queens University Belfast - Organic synthesis and bio-synthesis

Dr John McGrath
School of Biology and Biochemistry, Queens University Belfast

Professor Heinz Decker,
University of Mainz, German

Dr Annette Byrne,
Royal College of Surgeons, Dublin, Ireland - Cancer biology

Dr Jasmina Nikodinovic
Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia - Biocatalysis

Dr Manfred Zinn. 
HES-SO Valais Wallis, Switzlerand - Biodegradable polymer (PHA) production

Dr Auxi Prieto.  
CSIC, Madrid, Spain - Biodegradable polymer (PHA) production.