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researcher

Tadhg Ó'Cróinín

Lecturer

School of Biomolecular & Biomedical Science
Room C140
Health Sciences Centre
Belfield
Dublin 4

Tel: +353 1 7166661
Email: tadhg.ocroinin@ucd.ie

Biography

2008-present        Lecturer in the School of Biomolecular and Biomedical Science, University College Dublin

2004-2007              SFI Research Fellow, Department of Microbiology, Trinity College Dublin

2001-2003              Postdoctoral Research Fellow, National Institutes of Health, Bethesda, USA

1999-2000              EMBO Postdoctoral Fellowship, Vrije Universiteit, Amsterdam.

1995-1999              Ph.D. University College Dublin

1991-1995              B.A.mod Trinity College Dublin


Research Links: SBBS Research  |  Biotechnology & Synthetic Biology Research in SBBS  |  Infection Biology Research in SBBS 

Tadhg O Croinin, Conway, Microbiology, Infection Biology, Gene Regulation, Campylobacter, Salmonella, Pathogenesis

Professional

 

Associations

Association: American Society of Microbiology (ASM), Function/Role: member
Association: Microbiology Society, Function/Role: Chair Elect of Professional Development Committee
     

Conference Contributions

Tadhg O Corinin (2013) [Conference Organising Committee Chairperson], Society for general microbiology (SGM) Irish division meeting. Microbial pathogenicity and the regulation of virulence, University College Dublin , 21-MAR-13 - 22-MAR-13.

Committees

Committee : Science Promotion Committee
Committee : Professional Development Committee - Microbiology Society
Committee : Irish Division of Microbiology Society
 

Education

Year 2016 Institution: University College Dublin
Qualification: Professional Diploma in University Teaching and Learning Subject: University Teaching and Learning
Year 1999 Institution: University College Dublin
Qualification: PhD Subject:
Year 1995 Institution: Trinity College Dublin
Qualification: BA Subject:
         

Publications

 

Book Chapters

Backert S., Tegtmeyer N, O Croinin T, Boehm M and Hemesaat M.M. (2016) 'Human Campylobacteriosis' In: Klein G (eds). Campylobacter : Features, Detection and Prevention of Foodborne Disease. UK/USA: Elsevier Academic Press. [Details]
Dorman C.J., O Croinin T, Mangan MW; (2007) 'Virulence gene regulation in Salmonella enterica serovar Typhimurium' In: Dorman C.J., O Croinin T, Mangan MW; (eds). Salmonella : Molecular Biology and Pathogenesis. United Kingdom: Horizon Press. , pp.67-79 [Details]
 

Peer Reviewed Journals

Eoin Scanlan, Laura Ardill, Matthew V.X. Whelan, Claire Shortt, Jarleth E. Nally, Billy Bourke and Tadhg O Croinin (2017) 'Relaxation of DNA Supercoiling leads to increased invasion of epithelial cells and protein secretion by Campylobacter jejuni'. Molecular Microbiology, 104 (1):92-104. [Details]
Shortt C, Scanlan E, Hilliard A, Cotroneo CE, Bourke B, Ó Cróinín T. (2016) 'DNA Supercoiling Regulates the Motility of Campylobacter jejuni and Is Altered by Growth in the Presence of Chicken Mucus'. mBio, 13 (5):e01227-16-e01227-16. [Details]
O Croinin T and Backert S. (2012) 'Host Epithelial Cell Invasion by Campylobacter jejuni: trigger or zipper mechanism?'. Frontiers in Cellular and Infection Microbiology, 2 (25). [Details]
Mangan MW, Lucchini S, O Croinin T, Fitzgerald S, Hinton JC and Dorman CJ; (2011) 'The nucleoid-associated protein HU controls three regulons that coordinate virulence, response to stress and general physiology in Salmonella enterica serovar Typhimurium'. Microbiology, . [Details]
O Croinin T and Dorman C.J.; (2007) 'Expression of the Fis protein is sustained in late-exponential- and stationary-phase cultures of Salmonella enterica serovar Typhimurium grown in the absence of aeration'. MOLECULAR MICROBIOLOGY, 66 (1):237-251. [Details]
O Croinin T, McCormack A, van Vliet AH, Kusters JG and Bourke B; (2007) 'Random mutagenesis to identify novel Helicobacter mustelae virulence factors'. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 50 (2):257-263. [Details]
O Croinin T, Carroll R, Kelly A and Dorman C.J.; (2006) 'Roles for DNA supercoiling and the Fis protein in modulating expression of virulence genes during intracellular growth of Salmonella enterica serovar Typhimurium'. MOLECULAR MICROBIOLOGY, 63 (3):869-882. [Details]
Mangan M, Lucchini S, Danino V, O Croinin T, Hinton J and Dorman CJ; (2006) 'THe integration host factor (IHF) regulon of Salmonella enterica serovar Typhimurium'. MOLECULAR MICROBIOLOGY, 59 (6):1831-1847. [Details]
Kelly A, Conway C, O Croinin T, Smith S.G.J. and Dorman C.J.; (2006) 'DNA supercoiling and the Lrp protein determine the directionality of fim switch DNA inversion in Escherichia coli K-12'. JOURNAL OF BACTERIOLOGY, 188 (15):5356-5363. [Details]
O Croinin T, Grippe V.K. and Merkel T.J.; (2005) 'Activation of the vrg-6 promoter of Bordetella pertussis by RisA'. JOURNAL OF BACTERIOLOGY, 187 (5):1648-1658. [Details]
OCroinin, T., Clyne, M., Appelmelk, B. J., and Drumm, B.; (2001) 'Antigastric Autoantibodies in Ferrets Naturally Infected with Helicobacter mustelae'. Infection and Immunity, 69 :2708-2713. [Details]
Forester N, Lumbsden J, O Croinin T, O'Toole P; (2001) 'Sequince and Antigenic Variability of the Helicobacter mustelae Surface Ring Protein Hsr'. INFECTION AND IMMUNITY, 69 :3447-3450. [Details]
OCroinin, T; Clyne, R; Drumm, B; ; (2000) 'Helicobacter mustelae infection of the ferret as a natural animal model for Helicobacter adherence studies'. Gut, 47 (NA):4-4. [Details]
Clyne M, O Croinin T, Suerbaum S, Josenhans C and Drumm B; (2000) 'Adherence of Isogenic Flagellum Negative Mutants of Helicobacter pylori and Helicobacter mustelae to Human and Ferret Gastric Epithelial Cells'. INFECTION AND IMMUNITY, 68 :4335-4339. [Details]
Clyne, M; OCroinin, T; Drumm, B; ; (2000) 'Adherence mechanism of Helicobacter pylori and Helicobacter mustelae to primary human and ferret gastric cells'. Gut, 47 (NA):1-1. [Details]
Clyne, M, O Croinin, T, Drumm, B, ; (1999) 'Mimicry of blood group antigen A by Helicobacter mustelae and H-pylori - Reply'. Journal of Gastroenterology, 116 (2):505-505. [Details]
O Croinin T, Clyne M and Drumm B; (1998) 'Molecular Mimicry of Ferret Gastric Epithelial Blood Group Antigen A by Helicobacter mustelae'. GASTROENTEROLOGY, 114 :690-696. [Details]
OCroinin, T; Clyne, M; Drumm, B; ; (1997) 'Helicobacter mustelae specific antibodies cross react with ferret gastric tissue'. Journal of Gastroenterology, 112 (4):1054-1054. [Details]
 

Conference Publications

M.V.X Whelan., J.C. Simpson and O Croinin T (2017) Investigation into the Role of DNA Supercoiling during Campylobacter jejuni Attachment and Invasion of Human Epithelial Cells Using an Imaging Based Approach American Society of Microbiology General Meeting [Details]
L. Ardill, G. Cagney and O Croinin T. (2017) Investigation into the Link between DNA Topology, Protein Secretion and Virulence in Campylobacter jejuni American Society of Microbiology General Meeting [Details]
M. Whelan, J. Simpson and O Croinin T (2016) Development of a qualitative and quantitative imaging based approach for the analysis of Campylobacter jejuni invasion of human epithelial cells Microscopy Conference of Ireland Annual Meeting [Details]
L. Ardill, E. Scanlan and O Croinin T (2016) Investigating the link between DNA topology, protein secretion and invasion in Campylobacter jejuni 8th MaxQuant Summer School [Details]
L. Ardill, E. Scanlan and O Croinin T (2015) Analysis of a novel secreteome and determination of changes to outer membrane proteins of Campylobacter jejuni induced by relaxation of DNA supercoiling Computational and Molecular Biology Symposium [Details]
A. O'Sullivan and O Croinin T (2015) RNA-Seq analysis reveals transcriptome changes mediated by relaxation of DNA Supercoiling in C. jejuni and S. Typhimurium SGM Irish Branch Meeting - Microbial Interfaces [Details]
A. O'Sullivan, E. Scanlan and O Croinin T (2014) RNA-Seq analysis reveals transcriptome changes mediated by relaxation of DNA Supercoiling in C. jejuni and S. Typhimurium European Conference on Computational Biology, Strasbourg [Details]
A. O'Sullivan, E. Scanlan and O Croinin T (2014) An investigation into the regulation of virulence factors by DNA Supercoiling in gastrointestinal pathogens Society for general microbiology (SGM) Irish Division meeting. Host-pathogen interactions: From animals to humans and back again [Details]
L. Ardill, O. McQuaid, E. Scanlan and O Croinin T (2014) Investigation into the effect of relaxed DNA supercoiling on the secreteome of C. jejuni Computational and Molecular Biology Symposium [Details]
E. Scanlan, C. Shortt, Bourke B and O Croinin T (2014) The influence of DNA relaxation on epithelial cell invasion by Campylobacter jejuni Society for general microbiology (SGM) Irish Division meeting. Host-pathogen interactions: From animals to humans and back again [Details]
E. Scanlan, C. Shortt, A. O'Sullivan, B. Bourke and O Croinin T (2013) Investigating the effect of DNA supercoiling on the ability of Campylobacter jejuni to associate with a human intestinal cell line CHRO 2013: 17th International workshop on Campylobacter, Helicobacter and related organisms [Details]
A. O'Sullivan, A. McMullan, E. Scanlan, C. Shortt and O Croinin T (2013) The regulation of DNA supercoiling genes in gastrointestinal pathogens and the effect of mucin on promoter activity (SGM) Irish division meeting. Microbial pathogenicity and the regulation of virulence [Details]
C. Shortt, E. Scanlan, B. Bourke and O Croinin T (2013) Environmental regulation of motility through DNA topology in Campylobacter jejuni (SGM) Irish division meeting. Microbial pathogenicity and the regulation of virulence [Details]
E. Scanlan, C. Shortt, B. Bourke and O Croinin T (2013) Measurement of Campylobacter jejuni promoter regions involved in DNA supercoiling regulation and infection of intestinal epithelial cells in different genetic backgrounds. Society for general microbiology (SGM) Irish division meeting. Microbial pathogenicity and the regulation of virulence [Details]
Shortt C, Scanlan E, Bourke B and O Croinin T (2013) DNA supercoiling acts as a key regulator of motility in Campylobacter jejuni CHRO 2013: 17th International workshop on Campylobacter, Helicobacter and related organisms [Details]
Scanlan E, Shortt C, Bourke B and O Croinin T (2012) A link between DNA topology and the invasive phenotype of Campylobacter jejuni SGM General Meeting [Details]
Shortt C, Scanlan E, Bourke B and O Croinin T (2012) DNA topology influences motility and chemotaxis in the enteric pathogen, Campylobacter jejuni SGM General Meeting [Details]
Scanlan E, Shortt C, Bourke B, and O Croinin T (2012) DNA Supercoiling in Campylobacter jejuni: A Potential Trigger for Invasion American Society of Microbiology, General Meeting [Details]
Shortt C, Scanlan E, Bourke, B and O Croinin T (2012) Alteration of DNA Topology leads to changes in Flagella gene expression in Campylobacter jejuni American Society of Microbiology, General Meeting [Details]
C. Shortt, Scanlan E, Bourke B and O Croinin T; (2011) The role of DNA supercoiling in the regulation of motility in Campylobacter jejuni SGM Irish Branch Meeting - Microbial Viruses: Genomics Evolution and Application in Ecology, Biotechnology and Medicine Queens University Belfast, , 19-APR-11 - 20-APR-11 [Details]
E. Scanlan, C. Shortt, B. Bourke and T. O Croinin; (2011) DNA supercoiling in Campylobacter jejuni : A potential global regulator of invasion SGM Irish Branch Meeting - Microbial pathogenesis the key to better therapies Institute of Technology Tallaght, , 01-SEP-11 - 02-SEP-11 [Details]
C. Shortt, E. Scanlan, B. Bourke and T. O Croinin; (2011) Transcriptional regulation of chemotaxis and motility through DNA supercoiling SGM Irish Branch Meeting - Microbial pathogenesis the key to better therapies Institute of Technology Tallaght, , 01-SEP-11 - 02-SEP-11 [Details]
N. Corcionivoschi, A. Alemka, M. Clyne, T. O¿Croinin, B. Bourke; (2009) Host Derived Reactive Oxygen Species Modulate Bacterial Tyrosine Phosphorylation Pathway to Attenuate CPS Production in Campylobacter jejuni 81-176 during Infection of Human Epithelial Cells American Society of Microbiology : Annual General Meeting [Details]
Mangan M, Lucchini S, Danino V, O Croinin T, Hinton J and Dorman CJ; (2006) Three overlapping yet distinct integration host factor (IHF) regulons in Salmonella enterica serovar Typhimurium SGM Irish Branch Meeting : Mechanism of Bacterial Adhesion and Invasion [Details]
O Croinin T, Carroll R, Kelly A and Dorman C.J.; (2006) The role of Fis and DNA supercoiling during intracellular survival of Salmonella enterica serovar Typhimurium SGM Irish Branch Meeting : Mechanisms of Bacterial Adhesion and Invasion [Details]
O Croinin T, Grippe V.K. and Merkel T.J.; (2003) Analysis of the regulation of the virulence repressed genes of Bordetella pertussis by BvgR and RisA American Society of Microbiology : Annual General Meeting [Details]
O Croinin T, Grippe V.K. and Merkel T.J.; (2003) Analysis of the regulation of the virulence repressed genes of Bordetella pertussis by BvgR and RisA Mid-Atlantic Microbial Pathogenesis Meeting [Details]
O Croinin T, Grippe V.K. and Merkel T.J.; (2002) Analysis of the regulation of the virulence repressed genes of Bordetella pertussis by BvgR and RisA 7th International Symposium on Bordetella pertussis , Cambridge England [Details]
O Croinin T, McCormack A, van Vliet AH, Kusters JG and Bourke B; (2000) Identification of Helicobacter mustelae Virulence Factors by Screening of a Random Insertional Mutant Library XIII International Workshop on Gastroduodenal Pathology and Helicobacter pylori, Rome, Italy [Details]
O Croinin T, McCormack A, van Vliet AH, Kusters JG and Bourke B; (2000) Identification of Helicobacter mustelae Virulence Factors by Screening of a Random Insertional Mutant Library American Gastroenterology Association : Annual General Meeting [Details]
Clyne M, O Croinin T and Drumm B; (1999) Adherence of Helicobacter pylori and Helicobacter mustelae to gastric cells studied using confocal microscopy American Society of Microbiology : Annual General Meeting [Details]
O Croinin T, Clyne M, Appelmelk B, Claeys D and Drumm B; (1999) Presence of anti-gastric atuoantibodies in ferrets naturally infected with Helicobacter mustelae American Society of Microbiology : Annual General Meeting [Details]
O Croinin T, Clyne M and Drumm B; (1997) Helicobacter mustelae specific antibodies cross-react with ferret gastric tissue Second European Meeting on Pathogenesis and Host Response in Helicobacter pylori infections [Details]
O Croinin T, Clyne M and Drumm B; (1997) Molecular mimicry of ferret gastric epithelial blood group antigen A by Helicobacter mustelae American Gastroenterology Association : Annual General Meeting [Details]
                                                                                                         

Letters

Clyne, M,O Croinin, T,Drumm, B (1999) Mimicry of blood group antigen A by Helicobacter mustelae and H-pylori - Reply. Letters [Details]
                           

Research

Research Interests

 My current research interest lies in the investigation of virulence gene regulation in bacterial pathogens during infection of the gastrointestinal tract. In particular I am interested in the role played by DNA supercoiling as a global regulator of virulence gene transcription in response to a variety of environmental signals which are encountered during the infectious cycle.

Research Projects

Sponsor : The Wellcome Trust (WT)
Title : An investigation of the molecular mechanism of invasion of human epithelial cells by Campylobacter jejuni using a novel in vitro model based on altering bacterial DNA topology
Start Date / End Date : 01-JUN-17 / 31-AUG-17
Sponsor : Microbiology Society
Title : An investigation into biofilm formation by freshly isolated strains of Campylobacter jejuni
Start Date / End Date : 01-JUN-17 / 31-AUG-17
Sponsor : University College Dublin (UCD)
Title : Investigation into virulence factors of Campylobacter jejuni
Start Date / End Date : 01-MAY-17 / 30-APR-19
Sponsor : Irish Research Council (IRC)
Title : Unravelling the molecular mechanism of invasion of human epithelial cells by Campylobacter jejuni
Start Date / End Date : 01-OCT-15 / 30-SEP-19
Sponsor : The Wellcome Trust (WT)
Title : An investigation into the association between biofilm formation and adherence/invasion of human epithelial cells by Campylobacter jejuni
Start Date / End Date : 06-JUN-16 / 31-JUL-16
Sponsor : University College Dublin (UCD)
Title : Survival mechanisms used by gastrointestinal pathogens under conditions resembling the supermarket environment.
Start Date / End Date : 24-MAY-16 / 30-JUN-17
Sponsor : University College Dublin (UCD)
Title : M.Sc Poject Supervision. TO'C.
Start Date / End Date : 09-MAY-12 / 01-JUN-16
Sponsor : Science Foundation Ireland (SFI)
Title : Characterisation of the role played by DNA supercoiling in the regulation of virulence genes of Campylobacter jejuni
Start Date / End Date : 01-SEP-10 / 31-AUG-14
Sponsor : University College Dublin (UCD)
Title : The interaction of pathogenic organism with mucosal surfaces and epithelial cells
Start Date / End Date : 26-MAY-08 / 01-DEC-09

Recent Postgraduates

Amber Hilliard 2017
Eoin Scanlan 2015
Claire Shortt 2014

Current Postgraduate Students

Matthew Whelan, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Laura Ardill, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201700   MICR40030     Microbiology: Microbiology Research Project
201700   MICR40150     Microbiology: Host Pathogen Interaction
201700   MICR30040     Microbiology: Microbial Diversity and Growth
201700   MICR40010     Microbiology: Recombinant DNA Technology
201700   MICR30070     Microbiology: Skills in Microbiology
       

Collaborators

Internal Collaborators

Dr Marguerite Clyne - School of Medicine UCD
Dr Billy Bourke - School of Medicine UCD

External Collaborators

Dr Jarlath Nally - USDA National Centers for Animal Health USA