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Researchers at UCD

researcher

Tara McMorrow

Senior Lecturer

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166819
Email: tara.mcmorrow@ucd.ie

Biography

2014-Present: Senior Lecturer in Pharmacology, UCD School of Biomolecular and Biomedical Science
2014-Present: Academic Director of Graduate and Continuing Professional Development Toxicology Programmes, UCD School of Biomolecular and Biomedical Science
2014-Present: Vice President Irish Society of Toxicology
2013-Present: Registered Toxicologist
2008-Present: Conway Fellow, UCD Conway Institute
2005-2014:
Lecturer in Pharmacology, Academic Director of MSc, Pre-masters and CPD Programmes, UCD School of Biomolecular and Biomedical Science, UCD Conway Institute

2002-2008: Conway Investigator, UCD Conway Institute
2002-2004: Specialist Lecturer and DMMC Senior Research Fellow, Dept. of Pharmacology, UCD Conway Institute
2000-2002: Conway Senior Research Fellow, Dept. of Pharmacology, UCD
1998-2000: Enterprise Ireland Postdoctoral Research Fellow, Dept. of Medical Microbiology, UCD
1995-1998: EU Postdoctoral Research Fellow, Erasmus University, Rotterdam, The Netherlands
1995: Enterprise Ireland funded PhD Graduate, NUI Galway

Research Links: SBBS Research  |  Biotechnology & Synthetic Biology Research in SBBS  |  Mechanisms of Disease Research in SBBS 

Professional

Honours and Awards

Year: 2013.
Title: Teacher of the Year Award
Year: 2008.
Title: UCD Seed Funding Award
Year: 2003.
Title: Irish Nephrological Society/ Amgen Research Award

Associations

Association: European Register of Toxicologists (ERT), Function/Role: Member
Association: Irish Society of Toxicology, Function/Role: Committee Member
Association: American Society of Nephrology, Function/Role: Member
Association: Irish Nephrological Society, Function/Role: Member
     

Conference Contributions

Dr Tara McMorrow (2013) microRNA and mRNA expression profiling in human proximal tubular epithelial cells treated with high glucose. [Invited Oral Presentation], European Renal Cell Study Group Annual Conference, Oxford, England , 21-MAR-13 - 24-MAR-13.
T. McMorrow (2011) Identification of Biomarkers of CsA Nephrotoxicity in an animal model. [Invited Lecture], Singapore Laboratory Animal Research Conference, Singapore , 12-DEC-11 - 15-DEC-11.
Tara McMorrow; (2011) Candidate Biomarkers from in vitro models. [Invited Lecture], SysKid Annual Meeting, Innsbruck, Austria , 26-JAN-11 - 28-JAN-11.
McMorrow, T.; (2005) RNA interference: a novel alternative approach in nephrotoxicity studies. [Invited Oral Presentation], 5th World Congress on Alternatives and Animal use in the Life Sciences, Berlin, Germany , 01-AUG-05.
McMorrow, T.; (2004) Use of RNAi to elucidate the role of gene expression in in vitro nephrotoxicity. [Invited Oral Presentation], Ecopa Science Initiative, Alicante, Spain , 01-OCT-04.
McMorrow, T.; (2002) Mechanisms of Immune-mediated Renal Epithelial-Mesenchymal Transdifferentiation. [Invited Oral Presentation], Irish Nephrological Society and the UK Nephrogenesis Group, Dublin, Ireland , 01-MAY-02.
 

Employment

Employer: Erasmus University, Rotterdam
Position: EU Postdoctoral Research Fellow
Employer: UCD
Position: Enterprise Ireland Postdoctoral Research Fellow
Employer: Conway Institute, UCD
Position: Conway Postdoctoral Research Fellow
Employer: Conway Institute, UCD
Position: DMMC Senior Research Fellow
Employer: UCD
Position: Lecturer

Education

Year 1995 Institution: NUI Galway
Qualification: PhD Subject: Molecular Biology
         

Publications

 

Book Chapters

Slattery C, Cassidy H, Johnston O, Ryan MP and McMorrow T (2012) 'Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury' In: Slattery C, Cassidy H, Johnston O, Ryan MP and McMorrow T (eds). Chronic Kidney Disease and Renal Transplantation. India: Research Signpost. [Details]
O'Connell S, Nolan S, Slattery C, Ryan MP, McMorrow T. (2012) 'The role of Transglutaminase in Kidney Disease' In: O'Connell S, Nolan S, Slattery C, Ryan MP, McMorrow T (eds). Fibronectin and Disease. Croatia: Intech. [Details]
McMorrow T., Campbell E., Slattery C., Ryan M.P.; (2008) 'Altered gene expression and molecular Mechanisms modulating epithelial-mesenchymal transition in human renal epithelial cells' In: Paul J Higgins (eds). Human Epithelial Tumor Cell Plasticity: Implications for Cancer Progression and Metastasis. India: Research Signpost. , pp.209-235 [Details]
 

Peer Reviewed Journals

Herwig R, Gmuender H, Corvi R, Bloch KM, Brandenburg A, Castell J, Ceelen L, Chesne C, Doktorova TY, Jennen D, Jennings P, Limonciel A, Lock EA, McMorrow T, Phrakonkham P, Radford R, Slattery C, Stierum R, Vilardell M, Wittenberger T, Yildirimman R, Ryan M, Rogiers V, Kleinjans J. (2015) 'Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective'. Archives of Toxicology, 2 . [Details]
Slyne J, Slattery C;McMorrow T;Ryan MP (2015) 'New developments concerning the proximal tubule in diabetic nephropathy: in vitro models and mechanisms'. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30 Suppl 4 :1-7. [DOI] [Details]
Cassidy H, Slyne J;O'Kelly P;Traynor C;Conlon PJ;Johnston O;Slattery C;Ryan MP;McMorrow T (2015) 'Urinary biomarkers of chronic allograft nephropathy'. Proteomics. Clinical applications, 9 (5-6):574-585. [DOI] [Details]
Sumayao R, McEvoy B, Martin-Martin N, McMorrow T, Newsholme P. (2013) 'Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line'. Experimental Physiology, 98 (10):1505-1517. [Details]
H. Cassidy, J.Slyne, H. Frain, C. Slattery , M.P. Ryan, T. McMorrow * (2013) 'High-Throughput Proteomic Approaches to the Elucidation of Potential'. Proteome science, 1 (2):159-179. [Details]
Radford R, Frain H, Ryan MP, Slattery C, McMorrow T. (2012) 'Mechanisms of chemical carcinogenesis in the kidneys'. International journal of molecular sciences, 14 (10):19416-19433. [Details]
Martin-Martin N, Dan Q, Amoozadeh Y, Waheed F, McMorrow T, Ryan MP, Szaszi K. (2012) 'RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier tightening in renal proximal tubular cells'. International Journal of Biochemistry & Cell Biology, 44 (1):178-188. [Details]
Bloch, KM,Yaqoob, N,Evans, A,Radford, R,Jennings, P,Boei, JJWA,McMorrow, T,Slattery, C,Ryan, MP,Gmuender, H,van Delft, JHM,Lock, EA (2012) 'Detection of genotoxic and non-genotoxic renal carcinogens in vitro in NRK-52E cells using a transcriptomics approach'. Toxicology Research, 1 :211-219. [DOI] [Details]
Limonciel, A,Wilmes, A,Aschauer, L,Radford, R,Bloch, KM,McMorrow, T,Pfaller, W,van Delft, JH,Slattery, C,Ryan, MP,Lock, EA,Jennings, P (2012) 'Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells'. Archives of Toxicology, 86 :1741-1751. [DOI] [Details]
Radford, R,Slattery, C,Jennings, P,Blaque, O,Pfaller, W,Gmuender, H,Van Delft, J,Ryan, MP,McMorrow, T (2012) 'Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle'. American Journal of Physiology-Renal Physiology, 302 :905-916. [DOI] [Details]
Jennings, P,Weiland, C,Limonciel, A,Bloch, KM,Radford, R,Aschauer, L,McMorrow, T,Wilmes, A,Pfaller, W,Ahr, HJ,Slattery, C,Lock, EA,Ryan, MP,Ellinger-Ziegelbauer, H (2012) 'Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model'. Archives of Toxicology, 86 :571-589. [DOI] [Details]
O'Connell, S,Tuite, N,Slattery, C,Ryan, MP,McMorrow, T (2012) 'Cyclosporine A-Induced Oxidative Stress in Human Renal Mesangial Cells: A Role for ERK 1/2 MAPK Signaling'. Toxicological sciences : an official journal of the Society of Toxicology, 126 :101-113. [DOI] [Details]
Martin-Martin, N,Dan, QH,Amoozadeh, Y,Waheed, F,McMorrow, T,Ryan, MP,Szaszi, K (2012) 'RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier tightening in renal proximal tubular cells'. International Journal of Biochemistry & Cell Biology, 44 :178-188. [DOI] [Details]
Radford R, Slattery C, Jennings P, Blaque O, Pfaller W, Gmuender H, Van Delft J, Ryan MP, McMorrow T (2012) 'Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle'. The Journal of physiology, 302 (8):1-16. [DOI] [Details]
Limonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P. (2012) 'Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells'. Archives of Toxicology, 86 (11):1741-1751. [Details]
Cassidy H, Radford R, Slyne J, O'Connell S, Slattery C, Ryan MP, McMorrow T (2012) 'The role of MAPK in drug-induced kidney injury'. Journal of Signal Transduction, 2012 . [DOI] [Details]
O'Connell S, Slattery C, Ryan MP, McMorrow T. (2012) 'Sirolimus enhances cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells'. Journal of transplantation, 2012 . [DOI] [Details]
Radford R, Slattery C, Jennings P, Blaque O, Pfaller W, Gmuender H, Van Delft J, Ryan MP, McMorrow T. (2012) 'Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle'. American Journal of Physiology-Renal Physiology, 302 (8):905-916. [Details]
O'Connell S, Tuite N, Slattery C, Ryan MP, McMorrow T. (2012) 'Cyclosporine A-induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling'. Toxicological sciences : an official journal of the Society of Toxicology, 126 (1):101-113. [Details]
Jennings P, Weiland C, Limonciel A, Bloch KM, Radford R, Aschauer L, McMorrow T, Wilmes A, Pfaller W, Ahr HJ, Slattery C, Lock EA, Ryan MP, Ellinger-Ziegelbauer H. (2012) 'Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model'. Archives of Toxicology, 86 (4):571-589. [Details]
Ellis JK, Athersuch TJ, Cavill R, Radford R, Slattery C, McMorrow T, Ryan MP, Ebbels TMD, Keun H (2011) 'Metabolic Response to Low Level Toxicant Exposure in a Novel Renal Tubule'. Molecular BioSystems, 7 (1):247-257. [Details]
Martin-Martin, N,Slattery, C,McMorrow, T,Ryan, MP (2011) 'TGF-beta(1) mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway'. American Journal of Physiology-Renal Physiology, 301 :1281-1292. [DOI] [Details]
Johnston, O,Cassidy, H,O'Connell, S,O'Riordan, A,Gallagher, W,Maguire, PB,Wynne, K,Cagney, G,Ryan, MP,Conlon, PJ,McMorrow, T; (2011) 'Identification of beta 2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods'. Proteomics Clinical Applications, 5 :422-431. [DOI] [Details]
O'Connell, S,Slattery, C,Ryan, MP,McMorrow, T; (2011) 'Identification of novel indicators of cyclosporine A nephrotoxicity in a CD-1 mouse model'. Toxicology and Applied Pharmacology, 252 :201-210. [DOI] [Details]
Ellis, JK,Athersuch, TJ,Cavill, R,Radford, R,Slattery, C,Jennings, P,McMorrow, T,Ryan, MP,Ebbels, TMD,Keun, HC; (2011) 'Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system'. Molecular BioSystems, 7 :247-257. [DOI] [Details]
Johnston, O., Cassidy, H., O¿Connell, S., O¿Riordan, A., Gallagher, W.M., Maguire, P. B., Wynne, K., Cagney, G., Ryan, M. P., Conlon, P. J., and McMorrow, T. ; (2011) 'Identification of beta2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods'. Proteomics Clinical Applications, 5 (7-8):422-431. [Details]
Martin-Martin N, Slattery C, McMorrow T, Ryan MP. (2011) 'TGF-β1 mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway'. American Journal of Physiology-Renal Physiology, 301 (6):1281-1292. [Details]
Johnston O, Cassidy H, O'Connell S, O'Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T.; (2011) 'Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods'. Proteomics Clinical Applications, 5 (7-8):422-431. [Details]
O'Connell S, Slattery C, Ryan MP, McMorrow T.; (2011) 'Identification of novel indicators of cyclosporine A nephrotoxicity in a CD-1 mouse model'. Toxicology & Applied Pharmacology, 252 (2):201-210. [Details]
H Cassidy, O Johnston, L Brennan, A O Riordan, P Conlon, MP Ryan, T Mc Morrow ; (2010) 'Metabolomic Analysis of Human(HOMO SAPIENS) Immunosuppressant Nephropathy Post Renal Transplantation'. IRISH J MED SCI, 7 . [Details]
Lynch, J,Nolan, S,Slattery, C,Feighery, R,Ryan, MP,McMorrow, T; (2010) 'High-Mobility Group Box Protein 1: A Novel Mediator of Inflammatory-Induced Renal Epithelial-Mesenchymal Transition'. American Journal of Nephrology, 32 :590-602. [DOI] [Details]
Martin-Martin N, Ryan G, McMorrow T, Ryan MP; (2010) ''Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression'. American Journal of Physiology-Renal Physiology, 293 (3):672-682. [Details]
J. Lynch, S. Nolan, C. Slattery, R. Feighery, M.P. Ryan, T. McMorrow; (2010) 'High-Mobility Group Box Protein 1: A Novel Mediator of Inflammatory-Induced Renal Epithelial-Mesenchymal Transition'. American Journal of Nephrology, 32 (6):590-602. [Details]
Jennings P, Aydin S, Bennett J, McBride R, Weiland C, Tuite N, Gruber LN, Perco P, Gaora PO, Ellinger-Ziegelbauer H, Ahr HJ, Kooten CV, Daha MR, Prieto P, Ryan MP, Pfaller W, McMorrow T; (2009) 'Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion'. Toxicology in Vitro, 23 (3):486-499. [Details]
O'Riordan A, Johnston O, McMorrow T, Wynne K, Maguire P, Hegarty JE, McCormick A, Watson AJ, Cagney G, Gallagher WM, Ryan MR; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (9):1338-1348. [Details]
Nee, L,O'Connell, S,Nolan, S,Ryan, MP,McMorrow, T; (2008) 'Nitric Oxide Involvement in TNF-alpha and IL-1 beta-Mediated Changes in Human Mesangial Cell MMP-9 and TIMP-1'. Nephron. Experimental nephrology, 110 (NA):59-66. [DOI] [Details]
Feighery, R., Maguire, P., Ryan, M. R., McMorrow, T., ; (2008) 'A proteomic approach to immune-mediated epithelial-mesenchymal transition'. Proteomics Clinical Applications, 2 (7-8):1110-1117. [Details]
Slattery, C., Ryan, M. P., McMorrow, T., ; (2008) 'Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells'. International Journal of Biochemistry & Cell Biology, 40 (10):2218-2229. [Details]
Slattery C, Ryan MP, McMorrow T.; (2007) 'E2A proteins: Regulators of cell phenotype in normal physiology and disease'. International Journal of Biochemistry & Cell Biology, doi:10.1016/j.biocel.2007.05.014 . [Details]
Nee, L,Tuite, N,Ryan, MP,McMorrow, T; (2007) 'TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells'. Nephron. Experimental nephrology, 107 :73-86. [DOI] [Details]
Feldman, G., Kiely, B., Martin, N., Ryan, G., McMorrow, T., Ryan, M.P.; (2007) 'Role for TGF-Beta in cyclosporine-induced modulation of renal epithelial barrier function'. Journal of the American Society of Nephrology, 18 (6):1662-1671. [Details]
Campbell, E., Slattery, C., Tuite, N., Nolan, S., Leonard, M., Ryan, M.P. and McMorrow, T.; (2006) 'RNA Interference: a novel alternative approach in nephrotoxicity studies'. ALTEX, 23 :406-409. [Details]
Slattery, C; McMorrow, T; Ryan, MP; ; (2006) 'Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis'. FEBS Letters, 580 (17):4021-4030. [Details]
Slattery, C., Campbell, E., McMorrow, T., Ryan, M.P.; (2005) 'Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition'. AMERICAN JOURNAL OF PATHOLOGY, 167 (2):395-407. [Details]
McMorrow, T,Gaffney, MM,Slattery, C,Campbell, E,Ryan, MP; (2005) 'Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 :2215-2225. [DOI] [Details]
Nee, LE; McMorrow, T; Campbell, E; Slattery, C; Ryan, MP; ; (2004) 'TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells'. Kidney International, 66 (4):1376-1386. [Details]
Campbell, E., Slattery, C., McMorrow, T., Ryan, M.P. ; (2004) 'Role of RAP GTPases in TGF-B Mediated Epithelial-Mesenchymal Transition'. Journal of the American Society of Nephrology, 15 . [Details]
Lynch, J., McMorrow, T., Ryan, M.P. ; (2004) 'Mechanisms of Immune Mediated Epithelial - Mesenchymal Transition (EMT) in Human Renal Proximal Tubular Cells: A Role for HMGB-1'. Journal of the American Society of Nephrology, 15 . [Details]
Nee, LE,McMorrow, T,Campbell, E,Slattery, C,Ryan, MP; (2004) 'TNF-alpha and IL-1 beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells'. Kidney International, 66 :1376-1386. [Details]
Gillemans, N; McMorrow, T; Tewari, R; Wai, A; Burgtorf, C; Drabek, D; Ventress, N; Langeveld, A; Higgs, D; Tan-Un, K; Grosveld, F; Philipsen, S; ; (2003) 'Comparative analysis of globin loci in pufferfish and man suggests a common origin of vertebrate globin loci and reveals a novel mammalian globin locus'. Blood Cells, Molecules and Diseases, 31 (1):161-161. [Details]
Gillemans, N,McMorrow, T,Tewari, R,Wai, AWK,Burgtorf, C,Drabek, D,Ventress, N,Langeveld, A,Higgs, D,Tan-Un, K,Grosveld, F,Philipsen, S; (2003) 'Functional and comparative analysis of globin loci in pufferfish and humans'. Blood, 101 :2842-2849. [DOI] [Details]
Slattery, C; McMorrow, T; Watson, A; Ryan, MP; ; (2002) 'Cyclosporin A-induced renal fibrosis: A genomic and functional investigation'. Journal of the American Society of Nephrology, 13 (NA):120-120. [Details]
Campbell, E; McMorrow, T; Watson, AJ; Ryan, MP; ; (2002) 'Differential gene expression in a renal model of TGF-beta mediated epithelial-mesenchymal transformation: Implications for tubular interstitial fibrosis'. Journal of the American Society of Nephrology, 13 (NA):544-544. [Details]
J. Flint, C. Tufarelli, J. Peden, K. Clark, R.J. Daniels, R. Hardison, W. Miller, S. Philipsen, K.C. Tan-Un, T. McMorrow, J. Frampton, B.P. Alter, A.M. Frischauf, D.R. Higgs.; (2001) 'Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster'. Human Molecular Genetics, 10 (4):371-382. [Details]
Nee, L; McMorrow, T; Ryan, MP; ; (2001) 'Signalling pathways involved in the regulation of MMP-9 (gelatinase B) and TIMP-1 by renal proximal tubular cells in response to TNF alpha and IL-1 beta'. British Journal of Pharmacology, 134 (NA). [Details]
Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; ; (2001) 'Pathways involved in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells'. British Journal of Pharmacology, 134 (NA). [Details]
T. McMorrow, A. van den Wijngaard, T. Trimborn, , P. Fraser, M. van Lohuizen, T. Jenuwein, M. Djabali, S. Philipsen, F. Grosveld and E. Milot.; (2000) 'Transcriptional activation of the b-globin locus by transcription factors and chromatin modifiers'. Embo Journal, 19 :4986-4996. [Details]
R. Calzolari, T. McMorrow, N. Yannoutsos, A. Langeveld and F. Grosveld.; (1999) 'Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and db-thalassemia affects g- but not b-globin gene expression'. Embo Journal, 18 :949-958. [Details]
F. Grosveld, E. De Boer, N. Dillon, J. Gribnau, T. McMorrow, E. Milot, T. Trimborn, M. Wijgerde and P. Fraser; (1998) 'The dynamics of globin gene expression and position effects'. Novartis Foundation Symposium, 214 :67-86. [Details]
T. McMorrow, A. Wagner, T. Harte and F. Gannon; (1997) 'Isolation and developmental expression of the non-Bohr beta-globin cDNA from Atlantic Salmon'. Gene, 189 :183-188. [Details]
T. McMorrow, A. Wagner, F. Deryckere and F. Gannon.; (1996) 'Structural Organization and Sequence Analysis of the Globin Locus in Atlantic Salmon'. DNA and cell biology, 15 :407-414. [Details]
F. Deryckere, L. Byrnes, A. Wagner, T. McMorrow and F. Gannon.; (1995) 'Salmon HNF1: cDNA Sequence, Evolution, Tissue Specificity and Binding to the Salmon Serum Albumin Promoter'. Journal of Molecular Biology, 247 :1-10. [Details]
A. Wagner, F. Deryckere, T. McMorrow and F. Gannon.; (1994) 'Tail-to-Tail Organization of the Atlantic Salmon Alpha- and Beta- globin genes'. Journal of Molecular Evolution, 38 :28-35. [Details]
 

Conference Publications

Helena Frain, Craig Slattery, Michael P Ryan, Tara McMorrow (2014) Investigations into the mechanisms and markers of kidney toxicity International Society of Toxicology Tox Letters, , pp.62-62 [Details]
Cassidy H, Slyne J, Johnston O, Brennan L, O'Riordan A, Conlon P, Ryan MP, McMorrow T (2011) Metabolomic Profiling Of Chronic Allograft Nephropathy (CAN) Resulting From Immunosuppressant Therapies In Post Renal Transplantation Patients HUPO 10th World Congress Geneva, Switzerland, , 03-SEP-11 - 07-SEP-11 [Details]
H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow ; (2010) Metabolomic Analysis of Human Immunosuppressant Nephropathy Post Renal Transplantation . In: Irish Journal of Medical Science eds. Proceedings of the Royal Academy of Medicine in Ireland Dublin, Ireland, [Details]
H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow ; (2010) Metabolomic Analysis in Immunosuppressant Nephropathy Irish Nephrological Society Conference, Dublin, Ireland [Details]
Robert Radford, Craig Slattery, Michael Ryan, Tara McMorrow; (2010) Deciliation of Kidney Epithelial Cells Is an Early marker of Carcinogenic Effects American Society of Cell Biology [Details]
Bloch K., Lock E.A., Jennings P., Limonciel A., Aschauer L., Boei J., Radford R., McMorrow T., Slattery C., Ryan M.P.; (2009) Cytotoxicity Studies With Two Renal Carcinogens In Human And Rat Renal Tubule Epithelial Cells In Vitro Toxicology Society Meeting, Liverpool, United Kingdom Liverpool, United Kingdom, [Details]
Martin N., Ryan G.E., McMorrow T., Ryan M.P.; (2008) Molecular Mechanisms of Immunosuppressant-Induced Alteration of Barrier Function in Renal Proximal Tubular Cells American Society of Nephrology [Details]
Bennett J., Ryan M.P., McMorrow T.; (2008) Molecular Mechanisms of Immunosuppressive Agents in Human Renal Proximal Tubular Cells American Society of Nephrology [Details]
Radford R., Ryan M.P., McMorrow T.; (2008) Development of Renal Cell Culture Models of Carcinogenesis within the E.U. CarcinoGENOMICS Project: Analysis of Epithelial Mesenchymal Transition (EMT) Induction American Society of Nephrology [Details]
Bennett, J., Ryan, M.P. and McMorrow, T.; (2007) Diiferential effects of Immunosuppressive agents in human renal proximal tubular cells . In: J.Am. Soc. Nephrol eds. American Society of Nephrology [Details]
Feighery, R., Ryan, M.P. and McMorrow, T.; (2007) Proteomic Approaches to Immune-Mediated Epithelial Mesenchymal Transition (EMT) in Renal Disease . In: J. Am. Soc. Nephrol eds. American Society of Nephrology [Details]
O'Connell S, McMorrow T, Ryan MP; (2006) Evidence for EMT in a CsA induced model of renal fibrosis American Society of Nephrology [Details]
O' Riordan A, McMorrow T, Johnston O, Gallagher W, Maguire P, Cagney G, Hegarty J, McCormick A, Watson AJ and Ryan MP.; (2006) Using SELDI-TOF-MS Apo A1 is a serum biomarker of chronic kidney disease, post orthotopic liver transplantation American Society of Nephrology [Details]
Johnston O, Conlon PJ, McMorrow T, O'Riordan A, Gallagher W, Maguire P, Wynne K, Cagney G, and Ryan MP.; (2006) Urinary B2-microglobulin as a novel potential biomarker for chronic allograft nephropathy American Society of Nephrology [Details]
Nolan S, Ryan MP, McMorrow T.; (2006) Implications of increased expression of tissue transglutaminase in immune-mediated renal EMT American Society of Nephrology [Details]
O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P.; (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Davey, L., McMorrow, T. and Ryan, M.P.; (2005) Differential effects of immunosuppressive agents in human renal proximal tubular cells American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McMorrow, T., Campbell, E., Slattery, C., Tuite, N. and Ryan, M.P.; (2005) RNA interference: A novel alternative approach in nephrotoxicity studies 5th World Congress of Alternatives to Animal experimentation Berlin, Germany, , 21-AUG-05 - 25-AUG-05 [Details]
Slattery, C., McMorrow, T. and Ryan, M.P.; (2005) The role of PKC-beta in cyclosporine A-induced tubulointerstitial fibrosis American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P.; (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P.; (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Tuite, N.M., McMorrow, T. and Ryan, M.P.; (2005) Gene expression patterns in human mesangial cells in response to cyclosporine A American Society of Nephrology Dublin, Ireland, , 09-NOV-05 - 13-NOV-05 [Details]
Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P.; (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McMorrow T, Campbell E, Slattery C, Tuite N and Ryan MP.; (2005) RNA interference: A novel alternative approach in nephrotoxicity studies World Congress on Alternatives to Animals [Details]
Tuite NM, McMorrow T and Ryan MP.; (2005) Gene expression patterns in human mesangial cells in response to cyclosporine A American Society of Nephrology Las Vegas, Nevada, USA, , 26-JUN-06 - 29-JUN-06 [Details]
Davey, L., McMorrow, T. and Ryan, M.P.; (2005) Differential effects of immunosuppressive agents in human renal proximal tubular cells American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McMorrow, T., Campbell, E., Slattery, C., Tuite, N. and Ryan, M.P.; (2005) RNA interference: A novel alternative approach in nephrotoxicity studies 5th World Congress of Alternatives to Animal experimentation Berlin, Germany, , 21-AUG-05 - 25-AUG-05 [Details]
Slattery, C., McMorrow, T. and Ryan, M.P.; (2005) The role of PKC-beta in cyclosporine A-induced tubulointerstitial fibrosis American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Lynch,J., McMorrow, T. and Ryan, M.P.; (2004) Mechanisms of immune mediated epithelial mesenchymal transition in human renal proximal tubular cells American Society of Nephrology [Details]
Slattery, C., McMorrow, T. and Ryan, M.P.; (2004) Cyclosporine A-induced epithelial mesenchymal transition: a role for PKC-beta American Society of Nephrology [Details]
Campbell, E., McMorrow, T. and Ryan, M.P.; (2004) Role of Rap GTPases in TGF-beta mediated epithelial mesenchymal transition American Society of Nephrology [Details]
Campbell, E; McMorrow, T; Watson, AJ; Ryan, MP; ; (2002) Differential gene expression in a renal model of TGF-beta mediated epithelial-mesenchymal transformation: Implications for tubular interstitial fibrosis American Society of Nephrology [Details]
Slattery, C; McMorrow, T; Watson, A; Ryan, MP; ; (2002) Cyclosporin A-induced renal fibrosis: A genomic and functional investigation American Society of Nephrology , pp.120-120 [Details]
Gaffney, M; McMorrow, T; Slattery, C; Watson, A; Brady, H; Ryan, MP; ; (2002) Cyclosporine A-induced transdifferentiation in renal tubular epithelial cells: Implications for renal fibrosis American Society of Nephrology [Details]
Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; ; (2001) Pathways involved in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells British Pharmacological Society [Details]
Nee, L; McMorrow, T; Ryan, MP; ; (2001) Signalling pathways involved in the regulation of MMP-9 (gelatinase B) and TIMP-1 by renal proximal tubular cells in response to TNF alpha and IL-1 beta British Pharmacological Society [Details]
Nee, L; McMorrow, T; Ryan, MP; ; (2001) Cytokine receptors and signalling pathways in TNF-alpha American Society of Nephrology [Details]
Nathwani, SM; McMorrow, T; Tuite, N; Dempsey, M; Ryan, MP; ; (2001) Possible role of p53 in cisplatin-induced apoptosis in renal tubular epithelial LLC-PK1 cells American Society of Nephrology [Details]
                                                                                         

Research

Research Interests

Our research involves the study of kidney fibrosis and end-stage renal disease. The incidence of end stage renal disease (ESRD) is rising at a rate of 8-10% per annum. While the initiating factors of the disease may vary, tubulo-interstitial fibrosis is a keMolecular and Cellular Biology of Renal Fibrosis. Our research involves the study of kidney fibrosis and end-stage renal disease. The incidence of end stage renal disease (ESRD) is rising at a rate of 8-10% per annum. While the initiating factors of the disease may vary, tubulo-interstitial fibrosis is a key event and indicates a likelihood of progression to ESRD. Therapeutic strategies to halt the progression to ESRD are very limited mainly because of a lack of understanding of the mechanisms involved in tubulo-interstitial fibrosis.

Molecular and Cellular Biology of Renal Fibrosis
We believe that a process known as epithelial-mesenchymal transition (EMT), whereby epithelial cells become more fibroblast-like, may be involved in the development of kidney fibrosis. EMT is a physiological process during embryo development but in the adult can play a fundamental role in the early stages of transformation, invasion and metastasis of cancer cells. This process involves the loss of epithelial cell markers such as E-cadherin and the increase in mesenchymal markers such as alpha-smooth muscle actin. We are using DNA microarray analysis to determine specific gene changes in cell culture models of renal fibrosis, including EMT models.

Renal Pharmacology and Toxicology
We are also interested in the development of models of renal cell injury, including the investigation of the role of immunosuppressant agents in renal fibrosis through the application of genomics and proteomics techniques. Studies on differentially regulated genes and proteins provide insights not only into immunosuppressant-induced renal fibrosis, but also into the molecular mechanisms underlying EMT in other contexts, including tumour biology and fibrosis of other organs. Further examination of differentially regulated genes may lead to the identification of novel genes and potential adjunct therapies.

The major focus of our research is providing new models to develop our understanding of the mechanisms of nephrotoxicity and kidney damage, with the aim of identifying new therapeutic targets and strategies.
    
Research Funding
EU
SFI
MRCG-HRB
Enterprise Ireland
IRCSET
UCD Seed Funding
American Cystinosis Foundation

Research Projects

Sponsor : Republic of Iraq Ministry of Education
Title : Toxicological Studies of Kidney Carcinogens Obaidi
Start Date / End Date : 01-JAN-14 / 31-DEC-16
Sponsor : Enterprise Ireland (EI)
Title : Analysis of the anti-ageing effects of the neutraceutical supplement MedColl® on skin cells.
Start Date / End Date : 14-MAR-13 / 14-MAR-14
Sponsor : University College Dublin Foundation Ltd.
Title : Baxter Newman Fellowship
Start Date / End Date : 01-SEP-14 / 30-NOV-16
Sponsor : Science Foundation Ireland (SFI)
Title : Molecular mechanisms of cilia loss in
Start Date / End Date : 01-APR-13 / 01-APR-17
Sponsor : University College Dublin (UCD)
Title : M.Sc. project Supervision TMcM
Start Date / End Date : 09-MAY-12 / 31-AUG-15
Sponsor : Cystinosis Foundation
Title : Role of nitric oxide in the kidney proximal tubular dysfunction associated with the Fanconi Syndrome in cystinosis
Start Date / End Date : 30-JAN-12 / 30-JAN-13
Sponsor : European Chemical Industry Council (CEFIC)
Title : Mechanism-based characteristics of systemic toxicity for Repdose database substances employing in vitro toxicogenomics
Start Date / End Date : 01-FEB-11 / 31-JAN-14
Sponsor : EC Framework (FP7)
Title : Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)
Start Date / End Date : 01-JAN-10 / 31-DEC-14
Sponsor : Cystinosis Foundation Ireland
Title : Molecular mechanisms of muscle myopathy and pancreatic beta cell dysfunction associated with cystinosis: Determination of optimal approaches for cell protection
Start Date / End Date : 01-SEP-10 / 01-JUL-14
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Identifying the mechanisms of microalbuminuria and novel therapeutic targets in kidney disease
Start Date / End Date : 01-SEP-09 / 31-AUG-11
Sponsor : University College Dublin (UCD)
Title : Identification of Blomarkers in Kidney Disease Development using a Metabolomics Approach
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Science Foundation Ireland (SFI)
Title : Mechanisms and Potential Gene Targets in Immune Mediated Epithelial-Mesenchymal Transdifferentiation.
Start Date / End Date : 01-OCT-04 / 31-MAR-08
Sponsor : Health Research Board (HRB)
Title : Gene regulation and mechanism of epithelial-mesenchymal transdifferentiation (EMT) in a cyclosporine A-induced model.
Start Date / End Date : 01-OCT-03 / 30-SEP-06

Recent Postgraduates

Recently Graduated Postgraduate Students:
Hilary Cassidy PhD
Stephen Nolan PhD
Sein O'Connell PhD
Jason Bennett PhD
Ronan Feighery PhD
Robert Radford PhD
Geoffrey Watson MSc

Current Postgraduate Students

Michael Higgins, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Ismael Obaidi, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201500   PHAR40170     Pharmacology: Esntl Pharm for Toxicologist
201500   BIOC40130     Biochemistry: Medical Device Technology
201500   PHAR40280     Pharmacology: Prof. Skills for Toxicologists
201500   PHAR40270     Pharmacology: Env, Food, Occup Toxicology
201500   MICR40120     Microbiology: Facility Design
201500   BMOL40080     Biomolecular & Biomed Science: Teaching in Higher Education
201500   PHAR40180     Pharmacology: Experimental Tox and Risk Ass
201500   PHAR30010     Pharmacology: Chemotherapeutic agents
201500   PHAR40060     Pharmacology: Advanced Renal Pharmacology
       

Collaborators

Internal Collaborators

Prof. Michael Ryan
Conway Investigator,
School of Biomolecular and Biomedical Science,
Conway Institute

Dr. Lorraine Brennan,
Conway Investigator and Lecturer in Nutritional Biochemistry
School of Agriculture & Food Science
Conway Institute
Belfield
Dublin 4
 

External Collaborators

Dr. Roel Goldschmeding   
Department of Pathology,
Utrecht University Medical Centre, 
Heidelberglaan 100,
3584 CX Utrecht,
The Netherlands

Dr Paul Jennings
Experimental Nephrology,
Department of Physiology and Medical Physics,
Innsbruck Medical University,
Fritz-Pregl Strasse 3,
Austria 6020.