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researcher

Gethin McBean

School of Biomolecular & Biomedical Science

Tel: 00353-1-7166770
Email: gethin.mcbean@ucd.ie

Biography

1977                 BA (Mod) in Biochemistry, Trinity College Dublin
1982                 PhD in Pharmacology, University of Southampton, U.K.

Present position
2017-                 Professor, School of Biomolecular and Biomedical Science, University College Dublin  

2008-present     Fellow, Conway Institute of Biomolecular and Biomedical Research, UCD
 

Previous Positions
 
2007-2013         Head of School, UCD School of Biomolecular and Biomedical Science 

2006-2007         Head of Teaching and Learning, UCD School of Biomolecular and Biomedical Science

2005-2006         Head of Biochemistry, UCD School of Biomolecular and Biomedical Science 
 
2005-2017         Associate Professor, UCD School of Biomolecular and Biomedical Science

2003-2008         Principal Investigator, Conway Institute of Biomolecular and Biomedical Research, UCD

1990-2005         Lecturer, Department of Biochemistry, University College Dublin

1986-1989         Postdoctoral Research Fellow, Dept. of Biochemistry, Trinity College Dublin

1981-1984         Postdoctoral Research Fellow, University of Southampton

1978-1981         Research Assistant, Dept. of Physiology and Pharmacology University of Southampton, U.K.

1977-1978         Graduate Biochemist, Central Pathology Laboratories, Harley Street, London

Research Links: SBBS Research  | Mechanisms of Disease Research in SBBS
 

Gethin McBean, Conway, SBBS, UCD, biochemistry, neuroscience, glutamate, cysteine, glutathione, amino acid transport, astrocyte, metabolism, Thiol redox balance, MDMA, neurodegeneration, ALS, MND, HD

Professional

Honours and Awards

Year: 2002.
Title: UCD Presidents Research Award

Associations

Association: Royal Academy of Medicine in Ireland, Biological Sciences Section, Function/Role: Council Member
Association: Royal Academy of Medicine in Ireland, Function/Role: Fellow
Association: The Biochemical Society, UK, Function/Role: Member; Secretary, Neuroscience group 1997-2003 Member, Theme Panel V 2003-2004
Association: The European Society for Neurochemistry, Function/Role: Member
Association: The International Society for Neurochemistry, Function/Role: Member
     

Conference Contributions

Gethin McBean; (2007) International Drug of Abuse Research Symposium. [Invited Oral Presentation], International Society for Neurochemistry, Satellite Meeting on Drugs of Abuse, Merida, Mexico , 09-AUG-07 - 12-AUG-07.
Gethin McBean; (2006) National Scientific Research Meeting. [Conference Organising Committee Chairperson], Biological Sciences Section of The Royal Academy of Medicine in Ireland, UCD , 12-JAN-06 - 12-JAN-06.
Gethin McBean; (2005) Annual Conway Institute Research Meeting. [Conference Organising Committee Chairperson], Conway Festival of Research, UCD , 18-SEP-05 - 18-SEP-05.
Gethin McBean; (2004) Annual Conway Insitute Research Meeting. [Conference Organising Committee Chairperson], Conway Festival of Science, UCD , 19-SEP-04 - 19-SEP-04.
Gethin McBean; (2003) Annual Conway Insitiute Research Meeting. [Conference Organising Committee Chairperson], Conway Festival of Research, UCD , 20-SEP-03 - 20-SEP-03.

Committees

Committee : Neuroscience Panel, Health Research Board,
Committee : Neuroscience Committee of the Biochemical Society
Committee : Royal Academy of Medicine in Ireland, Biological Sciences Section
Committee : The Biochemical Society; Cell signalling theme panel
Committee : Conway Institute Seminar Committee
Committee : Conway Institute Postgraduate Education Committee
Committee : Teaching and Learning committee, SBBS
Committee : Teaching and Learning committee, College of Life Sciences

Employment

Employer: University of Southampton
Position: Research Fellow
Employer: Trinity College Dublin
Position: Research Fellow
Employer: University College Dublin
Position: Temporary College Lecturer
Employer: University College Dublin
Position: College Lecturer

Education

Year 1977 Institution: Trinity College Dublin
Qualification: BA(Mod) Subject: Biochemistry
Year 1982 Institution: Southampton University
Qualification: PhD Subject:
Year 1977 Institution: Trinity College Dublin
Qualification: BA Subject:
         

Publications

 

Book Chapters

McBean, G.J. (2016) 'Sulfur-containing amino acids: a neurochemical perspective' In: Lola Thompson (eds). Advances in Neurochemistry, Neuroscience Research Progress Series. New York: Nova Science Publishers Inc. , pp.1-24 Link to full text [Details]
McBean, G.J. (2013) 'The thiol redox system in glioma biology: clinical target and significance in resistance to glioma therapy' In: Wiranowska, M. and Vrionis, F.D., Eds (eds). Gliomas: symptoms, diagnosis and treatment options. New York: Nova Science Publishers. , pp.321-340 Link to full text [Details]
McBean, G.J. (2012) 'Astrocytes and the regulation of cerebral cysteine/cystine redox potential: implications for cysteine neurotoxicity' In: Chorkina, F.V. and Karatev, A.I., Eds (eds). Cysteine: biosynthesis, chemical structure and toxicity. New York: Nova Science Publishers. , pp.135-153 [Details]
McBean G.; (2007) 'Sulfur-containing amino acids' In: Lajtha A., Oja S., Schousboe A. and Saransaari P (eds). Handbook of Neurochemistry and Molecular Neurobiology. Vol.4, Amino acids and peptides in the nervous system. Berlin, Heidelberg: Springer-Verlag. , pp.133-154 [Details]
McBean G.J.; (1997) 'Receptors in the nervous system' In: Lynch M.A. and O'Meara S., Academic Press, San Diego (eds). Neuroscience Labfax. , pp.215-232 [Details]
McBean G. J., Horner E. B., Coueé I., Philips J. P., O'Brien M., Lee T. C. and Tipton K. F.; (1990) 'Enzymes and glial cells in brain damage and neurodegenerative disease' In: Dostert P., Reiderer P., Strolin Benedetti M. and Roncucci R. (eds). Early markers in Parkinson's and Alzheimer's Diseases Vol. 1. Vienna: Springer-Verlag. , pp.209-220 [Details]
 

Peer Reviewed Journals

Haslund-Vinding, J., McBean, G., Jaquet, V., Vilhardt, F. (2016) 'NADPH oxidases in microglia oxidant production: activating receptors, pharmacology and association with disease'. British Journal of Pharmacology, doi 10.1111/bph.13425 . [DOI] [Details]
McBean, G.J., López, M.G. and Wallner, F.K. (2016) 'Redox-based therapeutics in neurodegenerative disease'. British Journal of Pharmacology, doi 10.1111/bph.13551 . [DOI] [Details]
Orbán, C., Pérez-García, E., Bajnok, A., McBean, G., Toldi, G. and Blanco-Fernandez, A. (2016) 'Real time kinetic flow cytometry measurements of cellular parameter changes evoked by nanosecond pulsed electric field'. Cytometry Part A, 89 :472-479. [DOI] [Details]
Vilhardt, F., Haslund-Vinding, J., Jaquet, V., McBean, G. (2016) 'Microglia antioxidant systems and redox signaling'. British Journal of Pharmacology, doi 10.1111/bph.13426 . [DOI] [Details]
McBean, G.J., Aslan, M., Griffiths, H.R., Torrão, R.C. (2015) 'Thiol redox homeostasis in neurodegenerative disease'. Redox Biology, 5 :186-194. [DOI] Link to full text [Details]
Rojo, A.I., McBean, G., Cindric, M., Egea, J. Lopez, M.G., Rada, P, Zarkovic, N, Cuadrado, A. (2014) 'Redox control of microglial function: molecular mechanisms and functional significance'. Antioxidants & Redox Signaling, 21 (12):1766-1801. Link to full text [Details]
McBean G J (2012) 'The transsulfuration pathway: a source of cysteine for glutathione in astrocytes'. Amino Acids, 42 :199-205. Link to full text [Details]
Vines, A., McBean, G.J., Blanco-Fernández, A.; (2010) 'A flow-cytometric method for continuous measurement of intracellular Ca2+ concentration'. Cytometry Part A, 77 (11):1091-1097. [Details]
Kandil, S., Brennan, L. and McBean, GJ; (2010) 'Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells'. Neurochemistry International, 56 :611-619. [DOI] Link to full text [Details]
Godson C, Decker Y, McBean G, ; (2009) 'Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells'. American Journal of Physiology - Cell Physiology, 296 (6):1-7. [DOI] [Details]
McBean GJ, Murphy A, Vines A, ; (2009) 'Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx'. Biochimica et biophysica acta, 1788 :551-558. [DOI] [Details]
Kandil, S., Brennan, L., McBean, G., ; (2008) 'Differential effects of two gliotoxins on glutathione content in rat C6 glioma cells'. Journal of Neuroimmunology, 197 (2):169-169. [Details]
Vines, A., McBean, G., ; (2008) 'Calcium-mediated regulation of glutamate uptake in rat primary astrocytes'. Journal of Neuroimmunology, 197 (2):169-169. [Details]
Matthaes, S., McBean, G., ; (2008) 'The cystine-glutamate exchanger in 1321N1 astrocytoma cells'. Journal of Neuroimmunology, 197 (2):168-168. [Details]
McBean GJ, Montgomery T, Buon C, Eibauer S, Guiry PJ, Keenan AK, ; (2007) 'Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines'. British Journal of Pharmacology, 7 (NA):1121-1130. [DOI] [Details]
Quinn, S.T., Guiry, P.J., Schwabb, T., Keenan, A.K.; McBean, G.J.; (2006) 'Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro'. J. Autonomic and Autacoid Pharmacology, 26 (4):335-344. [Details]
Brennan, L; Alves, PM; Hewage, C; Malthouse, JPG; McBean, GJ; ; (2006) 'Impact of the gliotoxin L-serine-O-sulphate on cellular metabolism in cultured rat astrocytes'. Neurochemistry International, 48 (8):739-745. [Details]
Berry, CB; Hayes, D; Murphy, A; Wiessner, M; Rauen, T; McBean, GJ; ; (2005) 'Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid'. Journal of Brain Research, 1037 (1-2):123-133. [Details]
Hayes, D; Wiessner, M; Rauen, T; McBean, GJ; ; (2005) 'Transport of L-[C-14]cystine and L-[C-14]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells'. Neurochemistry International, 46 (8):585-594. [Details]
Brennan, L., Hewage, C., Malthouse, J.P.G. & McBean, G.J. ; (2004) 'Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C-NMR spectroscopic study'. NEUROCHEMISTRY, 2 :139-158. [Details]
Dervan, AG; Meshul, CK; Beales, M; McBean, GJ; Moore, C; Totterdell, S; Snyder, AK; Meredith, GE; ; (2004) 'Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease'. Experimental Neurology, 190 (1):145-156. [Details]
McBean GJ, Brennan L, Hewage C, Malthouse JP, ; (2004) 'Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study'. Neurochemistry International, 45 (8):1155-1165. [DOI] [Details]
Brennan, L., Hewage, C., Malthouse, J.P.G. & McBean, G.J.; (2003) 'An NMR study of alerations in [1-13C]glucose metabolism in C6 glioma cells by gliotoxic amino acids'. Neurochemistry International, 42 (6):441-448. [Details]
Berry, CB; McBean, GJ; ; (2003) 'An investigation into the role of calcium in the modulation of rat synaptosomal D-[H-3]aspartate transport by docosahexaenoic acid'. Journal of Brain Research, 973 (1):107-114. [Details]
Brennan, L; Hewage, C; Malthouse, JPG; McBean, GJ; ; (2003) 'An NMR study of alterations in [1-C-13]glucose metabolism in C6 glioma cells by gliotoxic amino acids'. Neurochemistry International, 42 (6):441-448. [DOI] [Details]
Murphy, JEJ, McBean, GJ, Guiry, PJ, McCormack, P, Baird, AW, Keenan, AK, ; (2002) 'In vitro effects of (+/-)-4-methylthioamphetamine, (+/-)-4-methylthiomethamphetamine and (+/-)-MDMA on vascular responses to noradrenaline and phenylephrine'. British Journal of Pharmacology, 136 (NA). [Details]
McBean,G.J.; (2002) 'Cerebral cystine uptake: a tale of two transporters'. Trends in Pharmacological Sciences, 23 (7):299-302. [Details]
Murphy, JEJ,Flynn, JJ,Cannon, DM,Guiry, PJ,McCormack, P,Baird, AW,McBean, GJ,Keenan, AK; (2002) 'In vitro neuronal and vascular responses to 5-hydroxytryptamine: modulation by 4-methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine'. European Journal of Pharmacology, 444 (NA):61-67. [DOI] [Details]
Cannon, D.M., Keenan, A.K., Guiry, P.J., Buon, C., Baird, A.W., and McBean, G.J.; (2001) 'In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA '. British Journal of Pharmacology, 134 :1455-1460. [Details]
McBean, GJ, Flynn, J, ; (2001) 'Molecular mechanisms of cystine transport'. Biochemical Society Transactions, 29 (NA):717-722. [Details]
Baird, AW, Moriarty, D, Guiry, P, McBean, GJ, Keenan, AK, ; (2001) '(+/-)-3,4 methylenedioxymethamphetamine (MDMA) stimulates electrogenic ion transport in rat colonic mucosa in vitro'. British Journal of Pharmacology, 134 (NA). [Details]
Cannon, DM; Keenan, AK; Guiry, PJ; Buon, C; Baird, AW; McBean, GJ; ; (2001) 'In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA'. British Journal of Pharmacology, 134 (7):1455-1460. [DOI] [Details]
Berry, CB, McBean, GJ, ; (2001) 'Structure activity relationships in the modulation of glutamate transport in synaptosomes and HEKGLT1 cells by fatty acids'. British Journal of Pharmacology, 134 (NA). [Details]
Murphy, JEJ, Cannon, DM, Guiry, P, McCormack, P, Baird, AW, McBean, GJ, Keenan, AK, ; (2001) 'A comparison of the in vitro effects of (+/-)-4-methylthioamphetamine and (+/-)-MDMA on 5-HT re-uptake in the brain and on vascular responses to 5-HT'. British Journal of Pharmacology, 134 (NA). [Details]
Flynn, J, McBean, GJ, ; (2000) 'Kinetic and pharmacological analysis of L-[S-35]cystine transport into rat brain synaptosomes'. Neurochemistry International, 36 (6):513-521. [Details]
Healy, J., Downes, A., and McBean, G.J.; (2000) 'Stimulation of synaptosomal D-[3H]aspartate transport by substance P in rat brain'. Neuroscience Letters, 290 :113-116. [Details]
Flynn, J., and McBean, G.J. ; (2000) 'Kinetic and pharmacological analysis of L-[35S]cystine transport into rat brain synaptosomes'. Neurochemistry International, 36 :513-521. [Details]
Healy, J; Downes, A; McBean, GJ; ; (2000) 'Stimulation of synaptosomal D-[H-3]aspartate transport by substance P in rat brain'. Neuroscience Letters, 290 (2):113-116. [Details]
De Souza, IEJ; McBean, GJ; Meredith, GE; ; (1999) 'Chronic haloperidol treatment impairs glutamate transport in the rat striatum'. European Journal of Pharmacology, 382 (2):139-142. [Details]
De Souza, I.E.J., McBean, G.J. and Meredith, G.E.; (1999) 'Chronic haloperidol treatment impairs glutamate transport in the rat striatum'. European Journal of Pharmacology, 382 :139-142. [Details]
Flynn, J, McBean, GJ, ; (1998) 'Characterisation of cystine transport in rat brain synaptosomes'. European Journal of Neuroscience, 10 (NA):352-352. [Details]
O'BYrne, M.B., Tipton, K.F., McBean, G.J. and Kollegger, H. (1997) 'Assessment of neurotoxicity and neuroprotection'. Journal of Neural Transmission, 50 (Suppl) :153-164. [Details]
OByrne, MB; Tipton, KF; McBean, GJ; ; (1996) 'The effects of 1-methyl-4-phenylpyridinium ion on biogenic amine levels in rat substantia nigra'. Biochemical Society Transactions, 24 (1):62-62. [Details]
Lundy, D.F. and McBean, G.J. (1996) 'Inhibition of the high affinity uptake of D-[3H]aspartate in rat brain by L-alpha-aminoadipate and arachidonic acid'. Journal of Neurological Sciences, 139 (Suppl) :1-9. [Details]
MCBEAN, GJ, DOORTY, KB, TIPTON, KF, KOLLEGGER, H, ; (1995) 'ALTERATION IN THE GLIAL-CELL METABOLISM OF GLUTAMATE BY KAINATE AND N-METHYL-D-ASPARTATE'. Toxicon, 33 (4):569-576. [Details]
Lundy, D.F. and McBean, G.J. (1995) 'Pre-incubation of synaptosomes with arachidonic acid potentiates inhibition of D[3H]aspartate transport'. European Journal of Pharmacology, 291 :273-279. [Details]
TIPTON, KF, MCBEAN, GJ, DAVEY, SP, ; (1995) 'NEUROTOXINS AND NEURODEGENERATIVE DISEASES'. Journal of Neurochemistry, 65 (NA):65-65. [Details]
McBean, G.J. (1994) 'The effect of L-alpha-aminoadipate on rat brain gamma-glutamylcysteine synthetase'. European Journal of Neuroscience, 5 (Suppl 6) :P159. [Details]
McBean, G.J. (1994) 'Inhibition of the glutamate transporter and glial enzymes in the rat striatum by the gliotoxin alpha-aminoadipate'. British Journal of Pharmacology, 113 :536-540. [Details]
KOLLEGGER, H, MCBEAN, GJ, TIPTON, KF, ; (1993) 'REDUCTION OF STRIATAL N-METHYL-D-ASPARTATE TOXICITY BY INHIBITION OF NITRIC-OXIDE SYNTHASE'. Biochemical Pharmacology, 45 (1):260-264. [Details]
Kollegger, H., McBean, G.J., Tipton, K.F. (1992) 'The inhibition of glutamine synthetase in rat striaum in vivo by methionine sulphoximine increases the neurotoxic effects of kainate and N-methyl-D-aspartate'. Neuroscience Letters, 130 :95-98. [Details]
McBean, G.J. (1992) 'Stereospecificity of the effects of alpha-aminoadipate on D-[3H]asptate uptake and glutamine synthetase activity in rat striatum'. Neurochemistry International, 21 (Suppl) :B9 No 35. [Details]
Kollegger, H., McBean, G.J. and Tipton, K.F. (1992) 'Striatal neurotoxicity is reduced by inhibition of nitric oxide synthase'. Neurochemistry International, 21 (Suppl) :B9 no 33. [Details]
KOLLEGGER, H, MCBEAN, GJ, TIPTON, KF, ; (1991) 'THE INHIBITION OF GLUTAMINE-SYNTHETASE IN RAT CORPUS STRIATUM INVITRO BY METHIONINE SULFOXIMINE INCREASES THE NEUROTOXIC EFFECTS OF KAINATE AND N-METHYL-D-ASPARTATE'. Neuroscience Letters, 130 (1):95-98. [Details]
McBean, G.J. (1990) 'Instriatal injection of DL-alpha-aminoadipate reduces kainate toxicity in vitro'. Neuroscience, 34 :225-234. [Details]
McBean, G.J. (1988) 'Toxicity of DL-alpha-aminoadipate to striatal cells in vivo and in vitro'. British Journal of Pharmacology, 95 (Suppl) :652P. [Details]
McBean, G.J. and Roberts, P.J. (1985) 'Neurotoxicity of L-glutamate and DL-threo-3(OH)aspartate in the rat striatum'. Journal of Neurochemistry, 44 :247-254. [Details]
Davies, S.W., McBean, G.J. and Roberts, P.J. (1984) 'A glutamatergic innervation of the nucleus basalis/substantia innominata'. Neuroscience Letters, 45 :105-110. [Details]
Steiner, H.X., McBean, G.J., Köhler, C., Roberts, P.J., Schwarcz, R. (1984) 'Ibotenate-induced neuronal degeneration in immature rat brain'. Brain Research, 307 :117-124. [Details]
Roberts, P.J., McBean, G.J., Butcher, S.P., Anand, H. and Kuonen, D. (1984) 'Evaluation of excitotoxin receptors'. Clinical Neuropharmacology, 6 :7. [Details]
McBean, G.J. and Roberts, P.J. (1984) 'Chronic infusion of L-glutamate causes neurotoxicity in rat striatum'. Brain Research, 290 :272-275. [Details]
McBean, G.J. and Roberts, P.J. (1982) 'Neurotoxicity of kainate and glutamate in the striatum'. British Journal of Pharmacology, 77 (Suppl) :501P. [Details]
Roberts, P.J., McBean, G.J., Sharif, N.A. and Thomas, E.M. (1982) 'Striatal glutamatergic function: modifications following specific lesions'. Brain Research, 235 :83-91. [Details]
McBean, G.J. and Roberts, P.J. (1981) 'Glutamate-preferring receptors regulate the release of D-[3H]aspartate from rat hippocampal slices'. Nature, 291 :593-594. [Details]
Rowlands, G.J.and Roberts, P.J. (1980) 'Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-strital tract'. Experimental Brain Research, 39 (239-240). [Details]
Rowlands, G.J. and Roberts, P.J. (1980) 'Release of glutamate from cortico-striatal terminals is regulated by dopamine receptors'. British Journal of Pharmacology, 70 :137P. [Details]
Rowlands G.J. and Roberts, P.J. (1980) 'Activation of dopamine receptors inhibits calcium-dependent glutamate release from cortico-strital terminals'. European Journal of Pharmacology, 62 :241-242. [Details]
Rowlands, G.J.and Roberts, P.J. (1980) 'Specific calcium-ion dependent release of L-glutamate from rat striatum'. Biochemical Society Transactions, 8 :109-110. [Details]

Other Journals

Montgomery, T.M., Sitte, H. and McBean, G. (2010) '4-methylthioamphetamine (4-MTA) induced mitochondrial-dependent apoptosis independently of dopamine and noradrenaline transporters' BMC Pharmacology 10 :A22. [Details]

Conference Publications

Montgomery, T. and McBean, G.J. (2010) 4-MTA (4-methylthioamphetamine) induced mitochondrial dependent apoptosis in SH-SY5Y cells independently of DAT and NET Austrian Pharmacological Society 16th Scientific symposium [Details]
Montgomery, T. and McBean, G.J. (2010) 4-MTA (4-methylthioamphetamine) induced mitochondrial dependent apoptosis in SH-SY5Y cells independently of DAT and NET Gordon Research Conference [Details]
Kandil, S., Brennan, L., McBean, G., ; (2008) Journal of Neuroimmunology Differential effects of two gliotoxins on glutathione content in rat C6 glioma cells , pp.169-169 [Details]
                       

Abstract

Leyden, C., Reynolds, A., McBean, G., Kennedy, B, Montgomery, T. M. (2014) Establisment of an in vivo screening assay for novel teratogemic compounds in Zebrafish. Abstract [Details]
Pes, L, McBean, G., Paradisi, F. (2013) Non-proteinogenic amino acid ACCA, its application and biological investigation. Abstract [Details]
Matthaes, S,McBean, G (2011) THE CYSTINE-GLUTAMATE EXCHANGER IN 1321N1 HUMAN ASTROCYTOMA CELLS. Abstract [Details]
McBean G.J.; (2011) Regulation of cysteine metabolism in astrocytes: impact on glutathione concentration. Abstract [Details]
Kandil, S,Brennan, L,McBean, G (2010) STIMULATION OF THE TRANSSULFURATION PATHWAY BY GLIOTOXINS IN C6 GLIOMA CELLS. Abstract [Details]
McBean, G.J.; (2010) The cystine glutamate exchanger and antioxidant defence in astrocytes. Abstract [Details]
Vines, A., McBean, G. and Blanco Fernández, A. ; (2009) A flow cytometric method for continuous measurement of intracellular calcium concentration. Abstract [Details]
Vines, A,McBean, G,Blanco, A (2009) A FLOW-CYTOMETRIC METHOD FOR CONTINUOUS MEASUREMENT OF INTRACELLULAR CA2+CONCENTRATION. Abstract [Details]
Vines, A., Blanco Fernández, A., Rogers, C. and McBean, G. ; (2009) A flow cytometric method for continuous measurement of intracellular calcium. Abstract [Details]
Vines, A., Blanco Fernández, A., Rogers, C. and McBean, G.; (2009) A flowcytometric method for continuous measurement of intracellular calcium. Abstract [Details]
Vines, A., McBean, G.J. and Blanco Fernández, A.; (2009) A flow-cytometric method for continuous measurement of intracellular Ca2+ concentration. Abstract [Details]
Matthaes, S. and McBean, G.; (2008) The cystine-glutamate exchanger in 1321N1 astrocytoma cells. J. Neuroimmunol. 197, p168: Abstract [Details]
Vines, A. and McBean, G.; (2008) Calcium-mediated regulation of glutamate uptake in rat primary astrocytes. J. Neuroimmunol. 197, p169: Abstract [Details]
Vines, A., Murphy, A. and McBean, G.; (2008) Intracellular calcium store-dependent modulation of EAAC1-mediated glutamate transport in C6 glioma cells. . Abstract [Details]
Matthaes, S. and McBean, G.; (2008) The cystine-glutamate exchanger in human 1321N1 astrocytoma cells. Ir. J. Med. Sci. 177, S379: Abstract [Details]
Kandil S., Brennan L. and McBean G. ; (2008) Differential effects of two gliotoxins on glutathione content in rat C6 glioma cells. J. Neuroimmunol. 197, p169: Abstract [Details]
Kandil S., Brennan L. and McBean G. ; (2008) Gliotoxin-mediated decrease in GSH synthesis in C6 glioma cells. Ir. J. Med. Sci. 177, S370: Abstract [Details]
Decker Y., McBean G. and Godson C.; (2008) Anti-inflammatory effects of lipoxin A4 in human 1321N1 astrocytoma cells. J. Neuroimmunol. 197, p168: Abstract [Details]
Kandil, S,Brennan, L,McBean, G (2008) Differential effects of two gliotoxins on glutathione content in rat C6 glioma cells. Abstract [Details]
Vines, A,McBean, G (2008) Calcium-mediated regulation of glutamate uptake in rat primary astrocytes. Abstract [Details]
Manthacs, S,McBean, G (2008) The cystine-glutamate exchanger in 1321N1 astrocytoma cells. Abstract [Details]
Montgomery, T., Guiry, P.J., Keenan, A.K. and McBean, G.J.; (2007) Modulation of [3H]noradrenaline and [3H]serotonin transport by structural analogues of 3,4-methylendioxymethamphetamine (MDMA). International Society of Neurochemistry, Satellite Symposium on Drugs of Abuse, Merida, Mexico: Abstract [Details]
Montgomerty, T., Guiry, P., Keenan, A.K. and McBean, G.J.; (2007) In vitro toxicity studies of MDMA analogues in PC12 cells. International Society for Neurochemistry. Satellite Symposium on Drugs of Abuse, Merida, Mexico: Abstract [Details]
Montgomery T.M., Guiry P., Keenan A. and McBean G.; (2006) In vitro modulation of monoamine transport by structural analogues of 3.4-methylenedioxymethamphetamine. Abstract [Details]
Quinn, S.T., Nyhan, L., Guiry, P.J., Keenan, A.K. and McBean, G.J.; (2005) Modulation of noradrenaline transport and release by 4-methylthioamphetamine in the rat aorta. International Society for Neurochemistry, Satellite Symposium on Drugs of Abuse, Venice, Italy: Abstract [Details]
Quinn S. T., Guiry P. J., McBean G. J. and Keenan A. K. ; (2005) 4-MTA signalling in rat aortic rings: the role of the noradrenaline transporter. Abstract [Details]
Brennan L., Hewage C., Malthouse J. P. G. and McBean G. J. ; (2005) Metabolic disruptions caused by gliotoxic amino acids. Abstract [Details]
Quinn S. T., Guiry P., McBean G. J. and Keenan A. K. ; (2004) Involvement of noradrenaline in the contractile effect of 4-methylthioamphetamine on isolated rat aorta. Abstract [Details]
Murphy A., Berry C. B., Hayes D. and McBean G. J. ; (2004) Fatty acid mediated regulation of glutamate transporters. Abstract [Details]
Hayes D., Berry C. B. and McBean G. J. ; (2003) Uptake of L-cystine by high affinity glutamate transporters over-expressed in HEK cells. Abstract [Details]
Dervan A. G., Beales M., Frederickson J., Meshul C. K., McBean G. J., Snyder A. K. and Meredith G. E. ; (2003) Chronic MPTP/probenecid treatment induces a significant gliosis but does not alter striatal glutamate levels or transport. Abstract Available Online [Details]
Murphy J. E. J., McBean G. J., Guiry P. J., McCormack P., Baird A. W. and Keenan A. K.; (2002) In vitro effects of (±)-4-methylthioamphetamine, (±)-4-methylthiomethamphetamine and (±)-MDMA on vascular responses to noradrenaline and phenylephrine. Abstract [Details]
Cannon D., McBean G. J., Baird A. W. and Keenan A. K.; (2001) The effects of MDMA on smooth muscle contraction in the rat. Abstract [Details]
Berry C. B. and McBean G. J. ; (2001) Structure-activity relationships in the modulation of glutamate transport in synaptosomes and HEKGLT1 cells by fatty acids. Abstract [Details]
Baird A. W., Moriatry D., Guiry P., McBean G. J. and Keenan A. K. ; (2001) (±)-3,4-methylenedioxymethamphetamine (MDMA) stimulates electrogenic ion transport in rat colonic mucosa in vitro. Abstract [Details]
Murphy J. E. J., Cannon D. M., Guiry P., McCormack P., Baird A. W., McBean G. J. and Keenan A. K.; (2001) A comparison of the in vitro effects of (±)MDMA and 4-methylthioamphetamine on 5-HT re-uptake in the brain and on vascular responses to 5-HT. Abstract [Details]
Flynn J. and McBean G. J. ; (1998) Characterisation of cystine transport in rat brain synaptosomes. Abstract [Details]
O'Byrne M. B., Tipton K. F. and McBean G. J. ; (1996) The effects of 1-methyl-4-phenylpyridinium ion on biogenic amine levels in rat substantia nigra. Abstract [Details]
Tipton K. F., McBean G. J. and Davey G. P. ; (1995) Neurotoxins and neurodegenerative diseases. Abstract [Details]
                       

Technical Publication

Vines, A., McBean, G.J., Blanco-Fernández, A. (2012) Continuous measurement of intracellular calcium on the BD Accuri (TM) C6 flow cytometer. Technical Publication Available Online [Details]
                                                             

Research

Research Interests

 My research focusses on understanding mechanisms of neuroprotection and the prevention of oxidative stress in the brain. My main interest is in the role played by sulphur-containing amino acids in thiol redox balance and antioxidant defence mechanisms in astrocytes and microglial cells. A particular focus is on regulation of the cystine-glutamate exchanger in glia and metabolic pathways (for example, the transsulphuration pathway) that maintain intracellular cysteine; also, how glial cells upregulate synthesis of the major brain antioxidant, glutathione in response to oxidative stress, cell activation or pathological conditions.  Currently, my group is investigating changes to sulphur amino acid metabolism in the brain as a result of the lysosomal storage disease, cystinosis. Experimental models include mammalian and human astrocyte and microglial cell lines and expression systems, and primary astrocytes. Techniques include measurement of the functional activity and expression of transporter proteins and enzymes, biochemical assays and molecular and imaging techniques.

 

 

     

Collaborators

Internal Collaborators

External Collaborators

  • Dr Antonio Campos Torres, University of Maynooth
  • Prof Harald Sitte, University of Vienna, Austria