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Researchers at UCD

Mike Scott

Associate Professor

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166925
Email: michael.scott@ucd.ie

Professional

Honours and Awards

Year: 1982.
Title: Recipient of Traveling Fellowship from Medical Research Council of Great Britain
Year: 1985.
Title: Recipient of Fellowship from John Douglas French Foundation for Alzheimer's Disease
Year: 2003.
Title: Recipient of ETS Walton Fellowship from Science Foundation Ireland
 

Patents

Patent 5,763,740 : Method for Detecting Prions in a Sample and Transgenic Animal Used for Same
Patent 5,789,655 : Method for Detecting Prions in a Sample and Transgenic Animal Used for Same
Patent 5,792,901 : Detecting Prions in a Sample and Prion Preparation and Transgenic Animal Used for Same
Patent 5,789,655 : Transgenic Animals Expressing Artificial Epitope-Tagged Proteins
Patent 5,908,969 : Method of Detecting Prions in a Sample and Transgenic Animal Used for Same
Patent 6,008,435 : Detecting Cow, Sheep and Human Prions in a Sample and Transgenic Mice Used for Same
Patent 6,150,583 : Transgenic Animals Expressing Artificial Epitope-tagged Proteins
Patent 6,214,366 B1 : Clearance and Inhibition of Conformationally Altered Proteins
Patent 6,322,802 : Method of sterilizing
Patent 6,419,916 : Assay for compounds which affect conformationally altered proteins
Patent 6,517,855 : Method of sterilizing
                     

Publications

 

Book Chapters

Prusiner, S. B., Scott, M.R., DeArmond, S. J.; (1999) 'Transmission and replication of prions' In: Prusiner, S. B (eds). Prion Biology and Diseases. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. , pp.147-190 [Details]
Scott, M., DeArmond, S. J., Prusiner, S. B.; (1999) 'Transgenetic investigations of the species barrier and prion strains' In: Prusiner, S. B (eds). Prion Biology and Diseases. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. , pp.307-347 [Details]
Prusiner, S. B., Kaneko, K., Vey, M., Telling, G., Scott, M., Gabizon, R., Taraboulos, A., DeArmond, S. J., Cohen, F. E.; (1998) 'Molecular biology of prion propagation' In: Morrison, D. R. O (eds). Prions and Brain Diseases in Animals and Humans. New York: Plenum Press. , pp.305-306 [Details]
Telling, G. C., SCOTT, M., Prusiner, S. B.; (1996) 'Deciphering prion diseases with transgenic mice' In: Gibbs, C. J (eds). Bovine Spongiform Encephalopathy: The BSE Dilemma. New York: Springer-Verlag. , pp.202-231 [Details]
SCOTT, M. R. D., Telling, G. C., Prusiner, S. B.; (1996) 'Transgenetics and gene targeting in studies of prion diseases' In: Prusiner. S. B (eds). Prions Prions Prions. Berlin: Springer-Verlag. , pp.95-123 [Details]
Telling, G., SCOTT, M., Prusiner, S. B.; (1996) 'Transgenetics and gene targeting in studies of prion diseases' In: New, M. I (eds). Where Genotype Does Not Match Phenotype. Italy: Serono Symposia Publications. , pp.237-266 [Details]
Prusiner, S. B., Carlson, G. A., DeArmond, S. J., Gabizon, R., Hsiao, K., SCOTT, M., Stahl, N., Westaway, D.; (1993) 'Transmissible and genetic prion diseases of humans and animals' In: Rosenberg, R. N., Prusiner, S. B., DiMauro, S., Bachi, R. L., Kunkel, L. M (eds). The Molecular and Genetic Basis of Neurological Disease. Stoneham, MA: Butterworth Heinemann. , pp.585-609 [Details]
Hsiao, K. K., Groth, D., SCOTT, M., Yang, S.-L., Serban, A., Rapp, D., Foster, D., Torchia, M., DeArmond, S. J., Prusiner, S. B.; (1992) 'Genetic and transgenic studies of prion proteins in Gerstmann-Sträussler-Scheinker disease' In: Prusiner, S. B., Collinge, J., Powell, J., Anderton, B (eds). Prion Diseases of Humans and Animals. London: Ellis Horwood. , pp.120-128 [Details]
Gabriel, J.-M., Oesch, B., Kretzschmar, H., SCOTT, M., Prusiner, S. B.; (1992) 'Molecular cloning and structural analysis of a candidate chicken prion protein' In: Prusiner, S. B., Collinge, J., Powell, J., Anderton, B (eds). Prion Diseases of Humans and Animals. London: Ellis Horwood. , pp.407-431 [Details]
Rogers, M., Taraboulos, A., SCOTT, M., Borchelt, D., Serban, D., Gyuris, T., Prusiner, S. B.; (1992) 'Modification and expression of prion proteins in cultured cells' In: Prusiner, S. B., Collinge, J., Powell, J., Anderton, B (eds). Prion Diseases of Humans and Animals. London: Ellis Horwood. , pp.457-469 [Details]
DeArmond, S. J., Jendroska, K., Yang, S.-L., Taraboulos, A., Hecker, R., Hsiao, K., Stowring, L., SCOTT, M., Prusiner, S. B.; (1992) 'Scrapie prion protein accumulation correlates with neuropathology and incubation times in hamsters and transgenic mice' In: Prusiner, S. B., Collinge, J., Powell, J., Anderton, B (eds). Prion Diseases of Humans and Animals. London: Ellis Horwood. , pp.483-496 [Details]
Brown, A.M.C., SCOTT, M.R.D.; (1987) 'Retroviral vectors' In: Glover, D.M (eds). DNA Cloning, Vol. III. Oxford, England: IRL Press. , pp.189-211 [Details]
SCOTT, M.R.D., Westaway, D., DeArmond, S.J., McKinley, M.P., Prusiner, S.B.; (1987) 'Central nervous system degeneration caused by prions' In: Glenner, G.G., Wurtman, R.J (eds). Advancing Frontiers in Alzheimer's Disease Research. Austin: Univ. of Texas Press. , pp.103-124 [Details]
Prusiner, S.B., Barry, R.A., Basler, K., DeArmond, S.J., Hood, L.E., Kent, S.B.H., Kretzschmar, H.A., McKinley, M.P., Oesch, B., SCOTT, M.R.D., Weissmann, C., Westaway, D.; (1987) 'Molecular biology of prion proteins' In: Prusiner, S.B., Barry, R.A., Basler, K., DeArmond, S.J., Hood, L.E., Kent, S.B.H., Kretzschmar, H.A., McKinley, M.P., Oesch, B., SCOTT, M.R.D., Weissmann, C., Westaway, D.; (eds). Prions Causing Scrapie and Creutzfeldt-Jakob Disease. Orlando: Academic Press. , pp.277-313 [Details]
Rigby, P.W.J., Brickell, P.M., Latchman, D.S., Murphy, D., SCOTT, M.R.D., Westphal, K.-H., Simanis, V., Lane, D.P., Willison, K.; (1984) 'Oncofetal genes and the major histocompatibility complex' In: Rigby, P.W.J., Brickell, P.M., Latchman, D.S., Murphy, D., SCOTT, M.R.D., Westphal, K.-H., Simanis, V., Lane, D.P., Willison, K.; (eds). Cancer Cells I/The Transformed Phenotype. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York: *. , pp.97-103 [Details]
Rigby, P.W.J., Brickell, P.M., Latchman, D.S., Murphy, D., Westphal, K.-H., SCOTT, M.R.D.; (1984) 'Oncogenic transformation activates cellular genes' In: Arber, W., Limensee, K., Peacock, W.J., Starlinger, P (eds). Genetic Manipulation: Impact on Man and Society. Miami: ISCU Press. [Details]
SCOTT, M.R.D., Brickell, P.M., Latchman, D.S., Murphy, D. Westphal, K.-H., Rigby, P.W.J.; (1983) 'The use of cDNA cloning techniques to isolate genes activated in tumor cells' In: Leukemia 5, Neth et al (eds). Modern Approaches to Human. *: *. [Details]
 

Peer Reviewed Journals

Karpuj, M., Giles, K., Gelibter, S., Scott, M., Lingappa, V., Szoka, F., Peretz, D., Denetclaw, W. Prusiner, S.B.; (2007) 'Phosphorothioate oligonucleotides reduce PrPSc levels and prion infectivity in cultured cells'. Molecular Medicine, 13 (3-4):190-198. [Details]
Peretz, D., Supattapone, S., Giles, K., Vergara, J., Freyman, Y., Lessard, P., Safar, J.G., Glidden, D.V., McCulloch, C., Nguyen, H.-O., Scott, M., Dearmond, S.J. & Prusiner, S.B; (2006) 'Inactivation of prions by acidic sodium dodecyl sulfate'. JOURNAL OF VIROLOGY, 80 (1):322-331. [Details]
Scott, M.R., Peretz, D., Nguyen, H.-O., Dearmond, S.J., Prusiner, S.B.; (2005) 'Transmission barriers for bovine, ovine, and human prions in transgenic mice'. Journal of Virology, 79 (9):5259-5271. [Details]
Safar, J. G., Scott, M., Monaghan, J., Deering, C., Didorenko, S., Vergara, J., Ball, H., Legname, G., Leclerc, E., Solforosi, L., Serban, H., Groth, D., Williams, E., Burton, D. R., Prusiner, S. B. and Williamson, R. A.; (2003) 'Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice'. Nature Biotechnology, 20 :1147-1150. [Details]
Peretz, D., Williamson, A., Legname, G., Matsunaga, Y., Vergara, J., Burton, D.R., DeArmond, S.J., Prusiner, S.B., Scott, M.R.; (2002) 'A change in the conformation of prions accompanies the emergence of a new prion strain'. Neuron, 34 :921-932. [Details]
Supattapone, S., Muramoto, T., Legname, G., Mehlhorn, I., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., Scott, M. R.; (2001) 'Identification of two prion protein regions that modify scrapie incubation time'. Journal of Virology, 75 :1408-1413. [Details]
Supattapone, S., Wille, H., Uyechi, L., Safar, J., Tremblay, P., Szoka, F.C., Cohen, F.E., Prusiner, S.B., Scott, M.R.; (2001) 'Branched polyamines cure prion-infected neuroblastoma cells'. Journal of Virology, 75 :3453-3461. [Details]
Supattapone, S., Bouzamondo, E., Ball, H. L. , Wille, H., Nguyen, H.-O. B., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., Scott, M.; (2001) 'A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice'. Molecular Cell Biology, 21 :2608-2616. [Details]
Peretz, D., Scott, M. R., Groth, D., Williamson, R. A., Burton, D. R., Cohen, F. E., Prusiner, S. B.; (2001) 'Strain-specified relative conformational stability of the scrapie prion protein'. Protein Science, 10 :854-863. [Details]
Zulianello, L., Kaneko, K., Scott, M., Erpel, S., Han, D., Cohen, F. E., Prusiner, S. B. ; (2000) 'Dominant negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein'. Journal of Virology, 74 :4351-4360. [Details]
Supattapone, S., Nguyen, H.-O. B., Muramoto, T., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., Scott, M.; (2000) 'Affinity-tagged miniprion derivatives spontaneously adopt protease-resistant conformations'. Journal of Virology, 74 :11928-11934. [Details]
Supattapone, S., Bosque, P., Muramoto, T., Wille, H., Aagaard, C., Peretz, D., Nguyen, H.-O. B., Heinrich, C., Torchia, M., Safar, J., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., Scott, M.; (1999) 'Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice'. Cell, 96 :869-878. [Details]
Supattapone, S., Nguyen, H-O. B., Cohen, F. E., Prusiner, S. B., Scott, M. R.; (1999) 'Elimination of prions by branched polyamines and implications for therapeutics'. Proceedings of the National Academy of Sciences of the, 96 :14529-14534. [Details]
Scott, M., Will, R., Ironside, J., Nguyen H-O. B., Tremblay,P., DeArmond, S.J., Prusiner, S. B.; (1999) 'Compelling transgenetic evidence for transmission of BSE prions to humans'. Proceedings of the National Academy of Sciences of the, 96 :15137-15142. [Details]
Hegde, R. S., Mastrianni, J. A., SCOTT, M. R., DeFea, K. A., Tremblay, P., Torchia, M., DeArmond, S. J., Prusiner, S. B., Lingappa, V. R.; (1998) 'A transmembrane form of the prion protein in neurodegenerative disease'. Science, 279 :827-834. [Details]
Prusiner, S. B., SCOTT, M. R., DeArmond, S. J., Cohen, F. E.; (1998) 'Prion protein biology'. Cell, 93 :1-20. [Details]
SCOTT, M. R., Safar, J., Telling, G., Nguyen, O., Groth, D., Torchia, M., Koehler, R., Tremblay, P., Walther, D., Cohen, F. E., DeArmond, S. J., Prusiner, S. B.; (1997) 'Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice'. Proceedings of the National Academy of Sciences of the, 94 :14279-14284. [Details]
Muramoto, T., DeArmond, S. J., SCOTT, M., Telling, G. C., Cohen, F. E., Prusiner, S. B.; (1997) 'Heritable neuronal disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an -helix'. Nat Medicine, 3 :750-755. [Details]
Kaneko, K., Vey, M., SCOTT, M., Pilkuhn, S., Cohen, F. E., Prusiner, S. B.; (1997) 'COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform'. Proceedings of the National Academy of Sciences of the, 94 :2333-2338. [Details]
Kaneko, K., Zulianello, L., SCOTT, M., Cooper, C. M., Wallace, A. C., James, T. L., Cohen, F. E., Prusiner, S. B.; (1997) 'Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation'. Proceedings of the National Academy of Sciences of the, 94 :10069-10074. [Details]
DeArmond, S. J., Sánchez, H., Yehiely, F., Qiu, Y., Ninchak-Casey, A., Daggett, V., Camerino, A. P., Cayetano, J., Rogers, M., Groth, D., Torchia, M., Tremblay, P., Scott, M. R., Cohen, F. E., Prusiner, S. B.; (1997) 'Selective neuronal targeting in prion disease'. Neuron, 19 :1337-1348. [Details]
Prusiner, S. B., Scott, M. R.; (1997) 'Prusiner, S. B., Scott, M. R.: Genetics of prions'. Annu. Rev. Genet, 31 :139-175. [Details]
SCOTT, M. R., Groth, D., Tatzelt, J., Torchia, M., Tremblay, P., DeArmond, S. J., Prusiner, S. B.; (1997) 'Propagation of prion strains through specific conformers of the prion protein'. Journal of Virology, 71 :9032-9044. [Details]
Muramoto, T., SCOTT, M., Cohen, F. E., Prusiner, S. B.; (1996) 'Recombinant scrapie-like prion protein of 106 amino acids is soluble'. Proceedings of the National Academy of Sciences of the, 93 :15457-15462. [Details]
Taraboulos, A., SCOTT, M., Semenov, A., Avrahami, D., Laszlo, L., Prusiner, S. B.; (1995) 'Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform'. Journal of Cell Biology, 129 :121-132. [Details]
Telling, G. C., SCOTT, M., Mastrianni, J., Gabizon, R., Torchia, M., Cohen, F. E., DeArmond, S. J., Prusiner, S. B.; (1995) 'Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein'. Cell, 83 :79-90. [Details]
Tatzelt, J., Zuo, J., Voellmy, R., SCOTT, M., Hartl, U., Prusiner, S. B., Welch, W. J.; (1995) 'Scrapie prions selectively modify the stress response in neuroblastoma cells'. Proceedings of the National Academy of Sciences of the, 92 :2944-2948. [Details]
Hsiao, K. K., Groth, D., SCOTT, M., Yang, S.-L., Serban, H., Rapp, D., Foster, D., Torchia, M., DeArmond, S. J., Prusiner, S. B.; (1994) 'Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein'. Proceedings of the National Academy of Sciences of the, 91 :9126-9130. [Details]
Telling, G. C., SCOTT, M., Hsiao, K. K., Foster, D., Yang, S.-L.,Torchia, M., Sidle, K. C. L., Collinge, J., DeArmond, S. J., Prusiner, S. B.; (1994) 'Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein'. Proceedings of the National Academy of Sciences of the, 91 :9936-9940. [Details]
Taraboulos, A., SCOTT, M., Semenov, A., Avrahami, D., Prusiner, S. B.; (1994) 'Biosynthesis of the prion proteins in scrapie-infected cells in culture'. Braz. J. Med. Bio. Res, 27 :303-307. [Details]
SCOTT, M., Groth, D., Foster, D., Torchia, M., Yang, S.-L., DeArmond, S. J., Prusiner, S. B.; (1993) 'Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes'. Cell, 73 :979-988. [Details]
Rogers, M., Yehiely, F., SCOTT, M., Prusiner, S. B.; (1993) 'Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells'. Proceedings of the National Academy of Sciences of the, 90 :3182-3186. [Details]
Prusiner, S. B., Fuzi, M., SCOTT, M., Serban, D., Serban, H., Taraboulos, A., Gabriel, J.-M., Wells, G., Wilesmith, J., Bradley, R., DeArmond, S. J., Kristensson, K.; (1993) 'Immunologic and molecular biological studies of prion proteins in bovine spongiform encephalopathy'. J. Infect. Dis, 167 :602-613. [Details]
SCOTT, M. R., Köhler, R., Foster, D., Prusiner, S. B.; (1992) 'Chimeric prion protein expression in cultured cells and transgenic mice'. Protein Science, 1 :986-997. [Details]
Hecker, R., Taraboulos, A., SCOTT, M., Pan, K.-M., Torchia, M., Jendroska, K., DeArmond, S. J., Prusiner, S. B.; (1992) 'Replication of distinct prion isolates is region specific in brains of trangenic mice and hamsters'. Genes & Development, 6 :1213-1228. [Details]
Raeber, A. J., Borchelt, D. R., SCOTT, M., Prusiner, S. B.; (1992) 'Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems'. Journal of Virology, 66 :6155-6163. [Details]
Gabriel, J.-M., Oesch, B., Kretzschmar, H., SCOTT, M., Prusiner, S. B.; (1992) 'Molecular cloning of a candidate chicken prion protein'. Proceedings of the National Academy of Sciences of the, 89 :9097-9101. [Details]
Westaway, D., Mirenda, C. A., Foster, D., Zebarjadian, Y., SCOTT, M., Torchia, M., Yang, S.-L., Serban, H., DeArmond, S. J., Ebeling, C., Prusiner, S. B., Carlson, G. A.; (1991) 'Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice'. Neuron, 7 :59-68. [Details]
Hsiao, K., SCOTT, M., Foster, D., DeArmond, S. J., Groth, D., Serban, H., Prusiner, S. B.; (1991) 'Spontaneous neurodegeneration in transgenic mice with prion protein codon 101 proline(leucine substitution'. Annals of the New York Academy of Science, 640 :166-170. [Details]
Rogers, M., Serban, D., Gyuris, T., SCOTT, M., Torchia, T., Prusiner, S. B.; (1991) 'Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system'. Journal of Immunology, 147 :3568-3574. [Details]
Borchelt, D.R., SCOTT, M., Taraboulos, A., Stahl, N., Prusiner, S.B.; (1990) 'Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells'. Journal of Cell Biology, 110 :743-752. [Details]
Rogers, M., Taraboulos, A., SCOTT, M., Groth, D., Prusiner, S.B.; (1990) 'Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites'. Glycobiology, 1 :101-109. [Details]
Taraboulos, A., Rogers, M., Borchelt, D.R., McKinley, M.P., SCOTT, M., Serban, D., Prusiner, S.B.; (1990) 'Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation'. Proceedings of the National Academy of Sciences of the, 87 :8262-8266. [Details]
Prusiner, S.B., SCOTT, M., Foster, D., Pan, K.-M., Groth, D., Mirenda, C., Torchia, M. Yang, S.-L., Serban, D., Carlson, G.A., Hoppe, P.C., Westaway, D., DeArmond, S.J.; (1990) 'Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication'. Cell, 63 :673-686. [Details]
Hsiao, K.K., SCOTT, M., Foster, D., Groth, D.F., DeArmond, S.J., Prusiner, S.B.; (1990) 'Spontaneous neurodegeneration in transgenic mice with mutant prion protein'. Science, 250 :1587-1590. [Details]
SCOTT, M.R.D., Foster, D., Mirenda, C., Serban, D., Coufal, F., Walchli, M., Torchia, M., Groth, D., Carlson, G., DeArmond, S.J., Westaway, D., Prusiner, S.B.; (1989) 'Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques'. Cell, 59 :847-857. [Details]
SCOTT, M., Butler, D., Bredesen, D., Walchli, M., Hsiao, K., Prusiner, S.B.; (1988) 'Prion protein gene expression in cultured cells'. Protein Engineering, 2 :69-76. [Details]
Butler, D.A., SCOTT, M.R.D., Bockman, J.M., Borchelt, D.R., Taraboulos, A., Hsiao, K.K., Kingsbury, D.T., Prusiner, S.B.; (1988) 'Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins'. Journal of Virology, 62 :1558-1564. [Details]
Basler, K., Oesch, B., SCOTT, M., Westaway, D., Walchli, M., Groth, D. F., McKinley, M. P., Prusiner, S. B., Weissmann, C; (1986) 'Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene'. Cell, 46 :417-428. [Details]
Chia, W., SCOTT, M.R.D., Rigby, P.W.J. Homer I; (1983) 'an efficient, disabled cosmid vector system for the construction of libraries of eukaryotic DNA'. Nucleic Acids Research, 10 . [Details]
SCOTT, M.R.D., Westphal, K.-H., Rigby, P.W.J. ; (1983) 'Activation of mouse genes in transformed cells'. Cell, 34 . [Details]
                                                                                             

Research

Research Interests

For much of my career, my area of research has been in the neurodegenerative diseases, and my major research interests include the mechanism of propagation of the agent (prion) of the transmissible spongiform encephalopathies (TSEs), the factors that affect susceptibility and resistance to foreign TSEs, the molecular basis of prion strain determination in the TSEs and the mechanism of neurodegeneration in amyloidoses such as the TSEs and Alzheimer's disease (AD). I also maintain an interest in practical applications of TSE research, including the development of treatments for neurodegenerative diseases, improved diagnostics, animal models and bioassays for TSEs.