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Therese Kinsella

Associate Professor of Biochemistry

School Of Biomolecular & Biomed Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166727
Email: therese.kinsella@ucd.ie

Biography

Research Theme with SBBS & Conway Institute: Vascular Biology
Research Links:  SBBS Research  |  Mechanisms of Disease Research in SBBS  

Academic awards/distinctions:

1981  College Scholar of the Year, University College Cork

1993   President's Research Award, University College Dublin.

1997   President's Research Award, University College Dublin

2000    Royal Irish Academy Medal in Biochemistry, 2000.

2004    President's Research Fellowship (2004-2005), University College Dublin.

2006    Elected member, Royal Irish Academy.             

2008    Biochemical Society (IAS) Gold Medal in Biochemistry, 2008.


Academic Positions:

2005 - Present Associate Professor of Biochemistry, University College Dublin

1999-2005 Statutory Lecturer, Biochemistry Department, UCD

1992-99 College Lecturer, Biochemistry Department, UCD

1990-91 Associate Scientist, Weis Centre for Research, Geisinger Clinic, PA, USA   

1989-90 Postdoctoral Research Fellow, Weis Centre for Research, PA, USA   

1986-89 Research Scientist, Guinness Worldwide Research Centre, Dublin   

1985-86 Postdoctoral Research Fellow, Biochemistry Department, UCC   

1985 PhD NUI
 
B. Therese Kinsella, Therese Kinsella, Thromboxane, prostacyclin, prostaglandin, receptor, isoform, gene, isoprenylation, rab, promoter, Ireland, university college Dublin, UCD, biochemistry, biomolecular, biomedical, welcome, Conway 

Professional

Honours and Awards

Year: 2008.
Title: Biochemical Society (Irish Area Section) Gold Medal Award in Biochemistry
Year: 1981.
Title: College Scholar of the Year, University College Cork
Year: 1993.
Title: President's Research Award, University College Dublin
Year: 1997.
Title: President's Research Award, University College Dublin
Year: 2004.
Title: President's Research Fellowship (2004-2005), University College Dublin
Year: 2006.
Title: Elected Member, Royal Irish Academy (MRIA)
Year: 2000.
Title: Royal Irish Academy Medal in Biochemistry

Associations

Association: Elan Corporation, Plc, EBR, Trinity College Dublin., Function/Role:
Association: Guinness Research Centre, St James¿s Gate, Dublin, Function/Role:
Association: Merck & Co. INC, Rathway, New Jersey, USA, Function/Role:
Association: Schering AG, Germany, Function/Role:
Association: Schering Plough Research Institute, Kenilworth, New Jersey, USA, Function/Role:
Association: Janssen Pharmaceutica N.V / Janssen Research Foundation, Beerse, Belgium, Function/Role:

Patents

Patent International P : A Modified Promoter Sequence -Gene Expression by Promoter1 of the human thromboxane receptor gene."
Patent 08141615.1. : "A Modified Promoter Sequence -Gene Expression by Promoter1 of the human thromboxane receptor gene."
Patent 90 18 26814 : Amylolytic Enzyme
   

Conference Contributions

Lawler O., Hayes J & Kinsella, BT.; Isoprenylation of the prostacyclin receptor. [Poster Presentation], Gordon Research Conference Mechanisms of Cell Signalling - G proteins, (1999), Singapore .
Miggin, SM & Kinsella, BT.; Differential expression of the human thromboxane A2 receptor isoforms. [Poster Presentation], 10th International Conference on Second Messengers & Phosphoproteins, Jerusalem, Israel .
Kinsella, BT; Vascular Hemostasis, A Biochemists Perspective. [Oral Presentation], Royal Irish Academy Medal Lecture in Biochemistry. Royal Irish Academy, Dublin on November 16th, 2000, * .
Kelley, LP & BT. Kinsella; Prostaglandin D2 receptor (DP) mediated desensitization of the alpha isoform of the human thromboxane A2 receptor. [Oral Presentation], Presented at G protein coupled receptor 2000 Symposium, Boston, MA. October 2000, * .
Miggin, SM & BT. Kinsella, ; Thromboxane A2 mediated MAPK activation through the human thromboxane A2 receptor a and b isoforms. [Non Refereed Paper/Abstract Presented at Conference], Experimental Biology 2001, Orlanda, Florida, March, 2001, * .
Kelley, LP & Kinsella, BT. ; Prostaglandin D2 receptor (DP) mediated desensitisation of the a isoform of the human thromboxane A2 receptor. [Oral Presentation], Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, September 2001, * .
Miggin, SM & Kinsella, B.T. ; Activation of the MAPK cascades through the human thromboxane A2 receptor a and b isoforms . [Poster Presentation], Conway Institute of Biomolecular and Biomedical Research Festival of Research,University College Dublin, September 2001, .
Lawler, OA & Kinsella, B.T.; The effects of Lovastatin and Cerivastatin on signaling by the prostacyclin receptor. [Poster Presentation], Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, September 2001, .
Kinsella, BT.; Vascular Hemostasis, A Biochemists Perspective. [Oral Presentation], Royal Irish Academy Medal Lecture in Biochemistry. Presented to the Biochemical Society, Dublin Meeting 2001, * .
Lawler, OA & BT. Kinsella; The effects of Lovastatin and Cerivastatin on signaling by the prostacyclin receptor. [Oral Presentation], Experimental Biology 2001, Orlanda, Florida, March, 2001, * .
Miggin, S.M. & B.T. Kinsella; MAPK activation through the human thromboxane A2 receptor a and b isoforms. [Oral Presentation], British Pharmacological Society, Dublin, July 2001, * .
Kelley, L.P & B.T.Kinsella; Desensitisation of the a isoform of the human thromboxane A2 receptor by prostaglandin D2 receptor (DP). [Oral Presentation], British Pharmacological Society, Dublin, July 2001, * .
Lawler, OA & B.T. Kinsella; The effects of the statins on prostacyclin receptor signalling. [Oral Presentation], British Pharmacological Society, Dublin, July 2001, * .
Freeman JE., C. Godson, and B.T. Kinsella; An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells. [Oral Presentation], British Pharmacological Society, Dublin, July 2001, * .
Freeman JE., B. McMahon, C. Godson, and B.T. Kinsella; Characterisation of thromboxane A2 and lipoxin A4 signalling in human mesangial cells. [Oral Presentation], Irish Nephrological Society AGM, March 2001, Royal College of Physicians of Ireland, * .
Miggin, SM & B.T. Kinsella; Thromboxane A2 mediated MAPK activation through the human thromboxane A2 receptor a and b isoforms . [Oral Presentation], Experimental Biology 2001, Orlanda, Florida, March, 2001, * .
Kelley, LP & BT. Kinsella; Prostaglandin D2 receptor (DP) mediated desensitization of the alpha isoform of the human thromboxane A2 receptor. [Oral Presentation], G protein coupled receptor 2000 Symposium, Boston, MA, USA .
Kelley, LP & BT. Kinsella,; Prostaglandin D2 receptor (DP)-mediated desensitisation of the a isoform of the human thromboxane A2 receptor. [Non Refereed Paper/Abstract Presented at Conference], Experimental Biology 2001, Orlanda, Florida, March, 2001, * .
Freeman JE., Godson C., and Kinsella, BT.; An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells. Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, September 2001, .
Freeman JE., Godson C., and Kinsella, BT.; An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells. [Oral Presentation], Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, May 2002, * .
Kelley, LP & Kinsella, BT.; Prostaglandin D2 receptor (DP)-mediated desensitization of the a isoform of the human thromboxane A2 receptor. [Poster Presentation], Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, May 2002, * .
Kinsella, BT.; Intracellular signalling by prostanoid receptors: novel insights. [Invited Oral Presentation], Inaugural International Advisory Committee Meeting, Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, May 2002, * .
B. Therese Kinsella; (2003) ·Intracellular Signalling by the prostacyclin receptors: Basic mechanisms and novel insights. [Invited Lecture], *, Division of Biochemistry and Molecular Biology, Davidson Building, Glasgow, U. K , 10-NOV-03.

Committees

Committee : UCD Research Strategy Board
Committee : Conway Institute for Biomolecular & Biomedical Research Executive Management Committee.
Committee : UCD College of Life Sciences Research Advisory Working Group (CRAWG)
Committee : Conway Institute for Biomolecular & Biomedical Research Executive Management Committee
Committee : UCD Research Strategy Board for formulating /advising on UCD Research Strategy 2009 ¿ 2013
Committee : UCD College of Life Sciences Research Advisory Working Group (CRAWG) to develop a research strategy for the UCD College of Life Sciences, aligning it to the UCD strategy on research & education (2008-2011).
Committee : UCD School of Biomolecular & Biomedical Science Schools Research Strategy Committee, with external advisory group Prospectus.
Committee : UCD PIYRA (SFI President of Ireland Young Researchers Award) Oversight Group to advise on applications and mentoring of UCD PIYRA Recipients
Committee : UCD Medicine and Radiography Degree Programme Board (College of Life Sciences Principal's Nominee Member
Committee : UCD Promotions Board (University Committee Academic Appointments Tenure and Promotion (UCAATP).for Review of Promotion to Associate Professor and Professor (2007)
Committee : Organizer of Research Performance & Quality (RPQ) Exercise, 2007
Committee : UCD Strategic Recruitment Committee, Theme Molecular and Translational Medicine, College of Life Sciences, UCD
Committee : UCD Promotions Board (UCAATP) for Review of Academic Staff Promotions to Senior Lecturer (2006)
Committee : College of Life Sciences Research & Innovation Committee, UCD
Committee : UCD School of Biomolecular & Biomedical Science Teaching & Learning Committee
Committee : UCD School of Biomolecular & Biomedical Science Research & Innovation Committee
Committee : Conway Institute for Biomolecular & Biomedical Research, UCD
Committee : Faculty of Science Schools Liason and Open Day (SLOD) Committee
Committee : Royal Irish Academy review panel for RIA/Irish Times best scientific article
Committee : Royal Irish Academy review panel for 2003 medal in Biochemistry
Committee : Human Research Subcommittee, Research Ethics Committee, UCD
Committee : M.Sc in Mammalian Cell Physiology degree programme, Department of Physiology, Trinity College Dublin.
Committee : Board of External Scientific Advisors to Kernel Capital Partners, Cork
Committee : Faculty of Science, UCD.
Committee : Cardiovascular Science assessment panel, Health Research Board.
Committee : International Committee, UCD
Committee : Sub-committee for Exemptions in Medicine, Nursing Studies, Physiotherapy and Radiography
Committee : Medical Teaching Committee, Biochemistry Dept
Committee : Merville Lay Seminar Committee, Conway Institute
Committee : Transcriptomics and Genomics Subcommittee, Conway Institute
Committee : Faculty of Medicine, UCD

Employment

Employer: Dept. Biochemistry, UCC
Position: Postdoctoral Fellow
Employer: Guinness Worldwide Research Centre, Dublin.
Position: Senior Molecular Biologist
Employer: Weis Center for Research, Geisinger Clinic, PA, USA.
Position: Postdoctoral Research Scientist
Employer: Weis Center for Research, Geisinger
Position: Associate Scientist
Employer: Centre for Cardiovascular Science, Dublin
Position: Associate Member
Employer: Dept, of Medicine & Exp. Therapeutics
Position: College Lecturer
Employer: Biochemistry Department
Position: College Lecturer
Employer: Biochemistry Department
Position: Statutory (Senior) Lecturer
Employer: University College Dublin
Position: Associate Professor of Biochemistry

Education

Year 1981 Institution: University College Cork
Qualification: BSc Subject:
Year 1985 Institution: University College Cork
Qualification: PhD Subject:
         

Publications

 

Book Chapters

Pratico D, O'Mahony D, Lawson J, Kinsella T, & Fitzgerald GA. ; (1997) 'Cellular activation by thromboxane A2 and 8‑epi‑PGF2a' In: Adv Exp Med Biol. , pp.229-233 Available Online [DOI] [Details]
O'Mahony, D.J., Kinsella, BT. & FitzGerald, G.A.; (1997) 'Cellular Responses to Eicosanoids: Molecular Biology of Eicosanoid Receptors' In: * (eds). Principles of Modern Medicine, Volume 8B Molecular and Cellular Pharmacology (Part 1). , pp.393-410 [Details]
Kinsella, BT., O'Mahony, DJ., Griffin, F. & FitzGerald, GA.; (1995) 'Regulated expression of the gene coding for the human Thromboxane A2 Receptor' In: Samuelsson B.' Ramwell PW., Paoletti R., Falco G., Granstrom E. & Nicosia S (eds). Advances in Prostaglandin, Thromboxane and Leukotriene Research. New York: Raven Press. , pp.247-251 [Details]
Maltese WA., Kinsella BT. & Sheridan KM.; (1992) 'Isoprenylation of Low Molecular Mass Guanine Nucleotide-Binding Proteins in Mammalian Cells' In: Nes DW, Parish EJ. & Trzaskos JM (eds). Regulation of Isopentenoid Metabolism. *: *. , pp.48-65 [Details]
 

Peer Reviewed Journals

Birrane G, Mulvaney EP, Pal R, Kinsella BT, Kocher O. (2013) 'Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1'. PLoS ONE, 8 (2). [DOI] [Details]
Keating GL, Reid HM, Eivers SB, Mulvaney EP & Kinsella BT. (2014) 'Transcriptional Regulation of the Human Thromboxane A2 Receptor Gene by Wilms' tumour (WT)1and hypermethylated in cancer (HIC) 1 in Prostate and Breast Cancer'. Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1839 (6):467-492. [DOI] [Details]
Turner EC, Kinsella BT. (2012) 'Regulation of the Human Prostacyclin Receptor Gene by the Cholesterol-responsive Sterol Response Element Binding Protein (SREBP) 1'. Journal of lipid research, 53 (11):2390-2402. [Details]
Reid HM, Turner EC, Mulvaney EP, Hyland PB, McLean C, Kinsella BT. (2012) 'Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP)'. Biochima Et Biophysica Acta - Molecular Cell Research, 1823 (10):1998-2012. [Details]
Keating GL, Turner EC, Kinsella BT. (2012) 'Regulation of the human prostacyclin receptor gene in megakaryocytes: Major roles for C/EBPδ and PU.1'. Biochimica et biophysica acta, 1819 :428-445. [Details]
Helen M. Reid, Katarina Wikström, David J. Kavanagh, Eamon P. Mulvaney & B. Therese Kinsella.; (2011) 'Interaction of Angio-associated Migragatory Cell Protein with the TP-Alpha and TP-Beta isoforms of the human Thromboxane A2 receptor'. Cellular Signalling, 23 (4):700-717. [Details]
Peter D. Donnellan, Cisca C. Kimbembe, Helen M. Reid & B. Therese Kinsella.; (2011) 'Identification of a Novel Endoplasmic Reticulum Export Motif within the Eighth a-Helical Domain (a-H8) of the human Prostacyclin Receptor'. Biochimica et biophysica acta, 1808 :1202-1218. [Details]
Turner, EC, Kavanagh, DJ, Mulvaney, EP, McLean, C, Wikstrom, K, Reid, HM & Kinsella, BT ; (2011) 'Identification of an interaction between the TPα and TPβ isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1'. J BIOL CHEM, 287 (17):15440-15457. [Details]
Turner EC, Mulvaney EP, Reid HR& Kinsella BT ; (2011) 'Interaction of the Human Prostacyclin Receptor with the PDZ adapter protein PDZK1: Role in Endothelial Cell Migration and Angiogenesis'. Molecular Biology of the Cell, 22 (15):2664-2679. [Details]
Turner EC, Mulvaney EP, Reid HR& Kinsella BT ; (2011) 'Interaction of the Human Prostacyclin Receptor with the PDZ adapter protein PDZK1: Role in Endothelial Cell Migration and Angiogenesis'. Molecular Cell Biology, 22 (15):2664-2679. [Details]
Lenahan, M. S. O'Brien, K. Kinsella, T. Sweeney, and J.J. Sheridan; (2007) 'Prevalence and molecular characterisation of Escherichia coli0 O157:H7 on Irish lamb carcasses, fleece and in faeces samples'. Journal of Applied Microbiology, 103 (6):2401-2409. [Details]
Lenahan, M. S. O'Brien, K. Kinsella, T. Sweeney, and J.J. Sheridan; (2007) 'Prevalence and molecular characterisation of Escherichia coli O157:H7 on Irish lamb carcasses, fleece and in faeces samples'. Journal of Applied Microbiology, . [Details]
Turner, N; Jackson, D; Renwick, L; Sutton, M; Kinsella, T; O'Callaghan, E; ; (2006) 'Purpose in life and DUP'. Schizophrenia Research, 86 (NA):122-122. [Details]
Whitty, P,Browne, S,Clarke, M,McTigue, O,Waddington, J,Kinsella, T,Larkin, C,O'Callaghan, E; (2004) 'Systematic comparison of subjective and objective measures of quality of life at 4-year follow-up subsequent to a first episode of psychosis'. Journal of Nervous and Mental Disease, 192 :805-809. [DOI] [Details]
Whitty, P; Browne, S; Clarke, M; McTigue, O; Waddington, J; Kinsella, T; Larkin, C; O'Callaghan, E; ; (2004) 'Systematic comparison of subjective and objective measures of quality of life at 4-year follow-up subsequent to a first episode of psychosis'. Journal of Nervous and Mental Disease, 192 (12):805-809. [Details]
Elizebeth C. Turner & B. Therese Kinsella; (2010) 'Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERa-dependent mechanism'. Journal of Molecular Biology, 396 :473-486. [Details]
Helen M. Reid, Eamon P Mulvaney, Elizebeth C. Turner and B. Therese Kinsella.; (2010) 'Interaction of the human Prostacyclin Receptor with Rab11: Characterization of a novel Rab11 binding domain (RBD) within a-Helix 8 that is regulated by Palmitoylation'. Journal of Biological Chemistry, 285 (24):18709-18726. [Details]
Gannon, AM,Kinsella, BT; (2008) 'Regulation of the human thromboxane A(2) receptor gene by Sp1, Egr1, NF-E2, GATA-1, and Ets-1 in megakaryocytes'. Journal of Lipid Research, 49 ((12)):2590-2604. [DOI] [Details]
Reid HM, Kinsella BT.; (2009) 'Intermolecular cross-talk between the prostaglandin E receptor (EP) subtype and thromboxane A(2) receptor signalling in human erythroleukaemic cells'. British Journal of Pharmacology, 158 (3):830-847. [Details]
Donnellan PD, Kinsella BT; (2009) 'Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively'. Journal of Molecular Signaling, 4 (7):1-23. [Details]
Gannon AM, Turner EC, Reid HM, Kinsella BT.; (2009) 'Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1'. Journal of Molecular Biology, 394 (1). [Details]
Elizabeth C. Turner & B. Therese Kinsella. ; (2009) 'Transcripional Regulation of the Human Prostacyclin Receptor Gene is dependent on Sp1, Pu.1 and Oct-1 in Megakaryocytes and Endothelial Cells'. Journal of Molecular Biology, 386 :579-597. [Details]
Katarina E. Wikström, David J. Kavanagh, Helen M. Reid & B.Therese Kinsella.; (2008) 'Differential Regulation of RhoA-mediated Signaling by the TPa and TPb isoforms of the human Thromboxane A2 Receptor:   Independent modulation of TPa signaling by Prostacyclin and Nitric Oxide. '. Cellular Signalling, 20 (8):1497-512. [Details]
AnneMarie M.Gannon & B. Therese Kinsella. ; (2009) 'The Wilms' Tumour suppressor protein WT1 acts as a key Transcriptional Repressor of the Human Thromboxane A2 Receptor Gene in Megakaryocytes'. Journal of cellular and molecular medicine, 13 (11-12):4571-4586. [Details]
Martina B. O'Keeffe, Helen M. Reid & B. Therese Kinsella. ; (2008) 'Agonist-dependent internalization and trafficking of the human prostacyclin receptor A Direct Role for Rab5a GTPase0'. Biochimica et Biophysica Acta, 1783 :1914-1928. [Details]
Katarina Wikström, Helen M. Reid, Maria Hill, Karol. A. English, Martina B. O'Keeffe, Cisca C. Kimbembe & B. Therese Kinsella; (2008) 'Recycling of the human prostacyclin receptor is regulated through a direct interaction with RAB11a GTPase'. Cellular Signalling, 20 (12):2332-2346. [Details]
Reid HM and Kinsella BT.; (2004) 'Investigation of the effect of nitric oxide on signalling by the  and  isoforms of the human thromboxane A2 receptor'. FASEB Journal, . Available Online [Details]
Reid Helen M & Kinsella B. Therese; (2007) 'Palmitoylation of the TPbeta isoform of the human thromboxane A(2) receptor. Modulation of G protein: Effector coupling and modes of receptor internalization'. Cellular Signalling, 19 (5):1056-1070. [Details]
Helen M. Reid & B. Therese Kinsella; (2007) 'Palmitoylation of the TP isoform of the human thromboxane A2 receptor'. Cellular Signalling, . [Details]
Mitchell D, O'Meara SJ, Gaffney A, Crean JK, Kinsella BT, Godson C.; (2007) 'The Lipoxin A4 Receptor Is Coupled to SHP-2 Activation:implications for regulation of receptor tyrosine kinases'. Journal of Biological Chemistry, 282 (21):15606-15618. [Details]
Julien Hanson, Jean-Michel Dogné, Ghiotto Jeremie, Anne-Lise Moray, B. Therese Kinsella & Bernard Pirotte.; (2007) 'Design, synthesis and SAR of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]- urea and 'cyanoguanidines as selective antagonists of the TP a and TP b isoforms of the human thromboxane A2 receptor'. Journal of Medicinal Chemistry, 50 (16):3928-3936. [Details]
Leanne P. Kelley-Hickie, Martina B. O'Keeffe, Helen M. Reid,& B. Therese Kinsella; (2007) 'Homologous desensitization of signalling by the alpha isoform of the human thromboxane A2 receptor: A specific role for nitric oxide signalling'. Biochimica et Biophysica Acta, :970-989. [Details]
Coyle AT, Miggin SM & Kinsella BT. ; (2002) 'Characterization of the 5' untranslated regions of the human thromboxane A2 receptor (TP) and  isoform mRNAs. Differential promoter utilization by the TP isoform transcripts'. European Journal of Biochemistry, . Available Online [Details]
Hanson, J., Reynaud, D., Qiao, N., Winum, J-Y., Renard, J.F., Kelley, L.P., Kinsella, B.T., Pirotte, B., Pace-Asciak, C.R., & Dogne, J.M.; (2006) 'Synthesis and pharmacological evaluation of original nitrobenzenic thromboxane modulators as anti-platelet agents acting on both the alpha and beta isiforms of the human thromboxane receptor'. Journal of Medicinal Chemistry, 49 (12):3701-3709. [Details]
Coyle AT, Kinsella BT.; (2006) 'Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A(2) receptor gene in human erythroleukemia cells'. Biochemical Pharmacology, 71 :1308-1323. [Details]
OMeara SJ & Kinsella BT.; (2005) 'The effect of the Farnesyl Protein Transferase inhibitor SCH66336 on isoprenylation and signalling by the Prostacyclin Receptor'. Biochemical Journal, 386 ((1)):177-189. [Details]
Hanson J, Rolin S, Reynaud D, Qiao N, Kelley LP, Reid HM, Valentin F, Tippins J, Kinsella BT, Masereel B, Pace-Asciak C, Pirotte B and Dogné J-M.; (2005) 'In vitro and in vivo pharmacological characterization of BM-613, a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist'. Journal of Pharmacology and Experimental Therapeutics, 313 :293-301. [Details]
Coyle, A.T., O'Keeffe, M.B. & Kinsella, B.T.; (2005) '15-Deoxy D12,14-prostaglandin J2 suppresses transcription by Promoter 3 of the human Thromboxane A2 receptor gene through Peroxisome Proliferator-Activated Receptor g in human erythroleukemia cells'. FEBS JOURNAL, 272 :4754-4773. [Details]
Helen M. Reid & B. Therese Kinsella. ; (2008) 'Palmitoylation of the TPb isoform of the human thromboxane A2 receptor: Implications for Receptor Trafficking. '. FASEB Journal, 22 :724-725. [Details]
Coyle AT, Kinsella BT.; (2005) 'Characterisation of Promoter 3 of the human thromboxane A2 receptor gene'. FASEB Journal, 19 :A297-A297. [Details]
Coyle AT & Kinsella BT.; (2005) 'Characterisation of Promoter 3 of the human thromboxane A2 receptor gene. A functional AP-1 and octamer motif are required for basal promoter activity. The FEBS Journal (2005), 272, 1-18. In press'. FEBS JOURNAL, 272 :1036-1053. [Details]
Reid HM, Kinsella BT. ; (2004) 'Investigation of the effect of nitric oxide on signalling by the alpha and beta isoforms of the human thromboxane A2 receptor'. FASEB Journal, 18 . [Details]
OMeara SJ & Kinsella BT.; (2004) 'Investigation of the effect of the Farnesyl Protein Transferase inhibitor R115777 on isoprenylation and intracellular signalling by the Prostacyclin Receptor'. British Journal of Pharmacology, 143 (2):318-330. [Details]
OMeara SJ & Kinsella BT; (2004) 'The effect of the Statin Atorvastatin on Intracellular Signalling by the Prostacyclin Receptor in vitro and in vivo'. British Journal of Pharmacology, 143 (2):292-302. [Details]
Kelley-Hickie LP & Kinsella BT.; (2004) 'EP1 and FP-mediated cross -desensitization of the alpha (a) and beta (b) isoforms of the human Thromboxane A2 receptor'. British Journal of Pharmacology, 142 :203-221. [Details]
Kelley-Hickie LP and Kinsella BT.; (2004) 'EP1 -induced cross-desensitisation of the alpha () and beta () isoforms of the human Thromboxane A2 receptor'. FASEB Journal, . Available Online [Details]
Reid HM & Kinsella BT.; (2003) 'The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization: Independant modulation of TPa signalling by Nitric Oxide and Prostacyclin'. Journal of Biological Chemistry, 278 (51):51190-51202. [Details]
Miggin SM, Lawler OA, Kinsella BT.; (2003) 'Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation'. Journal of Biological Chemistry, 278 :6747-6959. [Details]
Miggin SM & Kinsella BT.; (2003) 'Palmitoylation of the human prostacyclin receptor; Functional implications of Isoprenylation and Palmitoylation'. FASEB Journal, . Available Online [Details]
Kelley LP & Kinsella BT.; (2003) 'The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha (a) isoform of the human Thromboxane A2 receptor'. Biochimica et Biophysica Acta, 1621 :192-203. [Details]
Kelley-Hickie, L.P. & Kinsella, B.T.; (2006) 'Homologous desensitization of signalling by the beta (b) isoform of the human thromboxane A2 receptor. Agonist-mediated desensitization of TPb'. Biochim Biophys Acta, 1761 (9):1114-1131. [Details]
Miggin SM, Lawler OA, Kinsella BT.; (2002) 'Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor'. European Journal of Biochemistry, 269 :1714-1725. [Details]
Kinsella, BT., Erdman, RA. & Maltese, WA.; (1991) 'C-terminal amino acids'. Proceedings of the National Academy of Sciences of the, 88 :8934-8938. [Details]
Miggin, SM & Kinsella, BT.; (2002) 'Investigation of the mechanisms of G protein : effector coupling by the human and mouse prostacyclin receptors; identification of critical species-dependent differences'. Journal of Biological Chemistry, 277 :27053-27064. [Details]
Miggin S.M., B.T. Kinsella Mol Pharmacol. () , -31.; (2002) 'Regulation of Extracellular Signal-Regulated Kinase Cascades by alpha- and beta-Isoforms of the Human Thromboxane A(2) Receptor'. Molecular Pharmacology, 61 :817-831. [Details]
Coyle AT, Miggin SM & Kinsella BT.; (2002) 'Characterisation of the 5untranslated region of a and b isoforms of the human thromboxane A2 receptor (TP): Differential promoter utilisation by the TP isoforms'. European Journal of Biochemistry, 269 :4058-4073. [Details]
Miggin, SM & BT. Kinsella; (2001) 'Thromboxane A2-receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells'. Biochimica Et Biophysica Acta, 1539 (1-2):147-162. [Details]
Miggin SM, Kinsella BT. ; (2001) 'Activation of the MAPK cascades through the human thromboxane A(2) receptor alpha and beta isoforms'. FASEB Journal, 15 . [Details]
Miggin, SM & Kinsella, BT.; (2001) 'MAPK activation through the human thromboxane A2 receptor  and  isoforms'. BRITISH JOURNAL OF PHARMACOLOGY, . [Details]
Lawler OA, S.M. Miggin & B.T. Kinsella; (2001) 'Protein kinase A mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to Gs-, to Gi- and to Gq-coupled effector signalling'. Journal of Biological Chemistry, 276 :33596-33607. [Details]
Lawler, OA & Kinsella, BT.; (2001) 'The effects of Lovastatin and Cerivastatin on signaling by the prostacyclin receptor'. BRITISH JOURNAL OF PHARMACOLOGY, . [Details]
Lawler OA, Kinsella BT. ; (2001) 'The effects of Lovastatin and Cerivastatin on signaling by the prostacyclin receptor'. FASEB Journal, 15 . [Details]
Lawler, OA & Kinsella, BT.; (2001) 'The effects of the statins on prostacyclin receptor signalling'. BRITISH JOURNAL OF PHARMACOLOGY, . [Details]
Kinsella, BT.; (2001) 'Thromboxane A2 -signalling in humans: a "tail" of two receptors'. Biochemical Society Transactions, 29 :641-654. [Details]
Kelley, LP & Kinsella, BT.; (2001) 'Prostaglandin D2 receptor (DP)-mediated desensitisation of the  isoform of the human thromboxane A2 receptor'. FASEB Journal, . [Details]
Kelley LP & Kinsella BT.; (2001) 'Desensitisation of the alpha isoform of the human thromboxane A2 receptor by prostaglandin D-2 receptor (DP)'. British Journal of Pharmacology, 134 . [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) 'An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells'. BRITISH JOURNAL OF PHARMACOLOGY, . [Details]
Foley, JF., LP. Kelley & BT Kinsella; (2001) 'Prostaglandin D2 receptor (DP)-mediated desensitisation of the a isoform of the human thromboxane A2 receptor'. Biochemical Pharmacology, 62 :229-239. [Details]
Freeman JE, Godson C & Kinsella BT.; (2001) 'An investigation into thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells'. British Journal of Pharmacology, 134 . [Details]
Walsh, M-T., & BT. Kinsella; (2000) 'Regulation of the human prostanoids TPa and TPb receptor isoforms mediated through activation of the EP1 and IP receptors'. British Journal of Pharmacology, 131 :601-609. [Details]
Walsh, M-T., JF. Foley, .,B.T. Kinsella; (2000) 'The a, but not the b, isoform of the human thromboxane A2 receptor (TP) is a target for prostacyclin mediated desensitization'. Journal of Biological Chemistry, 275 :20412-20423. [Details]
Lawler, OA., Miggin, SM & Kinsella, BT.; (2001) 'The effects of the statins lovastatin and cerivasatin on signaling by the prostacyclin receptor'. British Journal of Pharmacology, 132 (8):1639-1649. [Details]
Walsh, M-T., J.F. Foley & B.T. Kinsella; (2000) 'Investigation of the role of the carboxyl terminal tails of thea and b isoforms of the human thromboxane A2 receptor (TP) in mediating receptor : effector coupling'. Biochimica et Biophysica Acta, 1496 (1-2):164-182. [Details]
Hayes, JS, O. Lawler, M.T. Walsh, B.T. Kinsella; (1999) 'The Prostacyclin Receptor is isoprenylated; isoprenylation is required for efficient receptor :: effector coupling'. Journal of Biological Chemistry, 274 :23707-23718. [Details]
Miggin, SM. & Kinsella, BT.; (1998) 'Expression and tissue distribution of the mRNA's encoding the human thromboxane A2 receptor (TP) a and b isoforms'. 1425 :543-557. [Details]
Walsh, MT., Foley JF. & Kinsella, BT.; (1998) 'Characterization of the role of N-linked glycosylation on the cell signaling and expression of the human thromboxane A2 receptor Alpha and Beta isoforms'. Journal of Pharmacology and Experimental Therapeutics, 286 . [Details]
Kinsella, BT., O'Mahony, DJ. & FitzGerald, GA.; (1997) 'The human thromboxane A2 receptor Ñ isoform (TPÑ ) functionally couples to the G-proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2Ñ'. Journal of Pharmacology and Experimental Therapeutics, 281 :957-964. [Details]
Pratico D, O'Mahony D, Lawson J, Kinsella T, & Fitzgerald GA.; (1997) 'Cellular activation by thromboxane A2 and 8﷓epi﷓PGF2a'. Advances in Experimental Medical Biology, :229-233. [Details]
Lambkin, I., Cagney, G., Kinsella, BT. & O'Mahony, DJ.; (1997) 'Identification of peptide mimetics from phage display libraries which bind to recombinant forms of the human thromboxane A2 receptor'. Journal of Controlled Release, 46 (1-2):190-191. [Details]
Kinsella, BT. and O'Mahony, DJ.; (1994) 'Lipid Modification of G proteins'. Trends in Cardiovascular Medicine, 4 :27-34. [Details]
Kinsella, BT., O'Mahony, DJ. and FitzGerald, GA. (; (1994) 'Phosphorylation and regulated expression of the human thromboxane A2 receptor'. Journal of Biological Chemistry, 269 :29914-29919. [Details]
Kinsella, BT., O'Mahony, DJ., Lawson, JA., Pratico, D. & FitzGerald, GA.; (1994) 'Cellular activation of thromboxane receptors'. Annals of the New York Academy of Sciences, 714 :270-278. [Details]
Smith, S.D., O'Mahony, D.J., Kinsella, BT. & Rothblum, L.I.; (1993) 'Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF. '. Gene Expression, 3 :229-236. [Details]
Kinsella, BT., O'Mahony, DJ. &FitzGerald, GA.; (1993) 'Regulation of the thromboxane receptor by phosphorylation in vivo. '. Blood, 82 :610-611. [Details]
Knaus, UG., Heyworth, PG., Kinsella, BT., Curnutte, JT. & Bokoch, GM.; (1992) 'Purification and characterization of Rac2: a cytosolic GTP-Binding protein that regulates human neutrophil NADPH oxidase'. Journal of Biological Chemistry, 267 :23,575-23,582. [Details]
Kinsella, BT. & Maltese, WA.; (1992) 'Rab GTP-Binding proteins with three different carboxyl-terminal cysteine motifs are modified in vitro by 20 carbon isoprenoids'. Journal of Biological Chemistry, 267 :3940-3945. [Details]
Maltese, WA., Kinsella, BT. & Sheridan, KM. (1992) In: "Regulation of Isopentenoid Metabolism". J. American Chemical Society 497, Chapter 6. Eds. Nes et al. ; (1992) 'Isoprenylation of Low Molecular Mass Guanine Nucleotide-Binding Proteins in Mammalian cells'. Journal of American Chemical Society, 497 :48-65. [Details]
Knaus UG, Heyworth PG, Kinsella BT et al.; (1992) 'Purification and characterization of Rac2 A cytosolic GTP binding-protein that regulated human neutrophil NADPH oxidase'. Circulation, 86 (4):10-10. [Details]
Kinsella, BT., Hogan, S. & Cantwell, B.A.; (1991) 'Primary structure and processing of the Candida tsukubaensis alpha glucosidase: homology with the rabbit intestinal sucrase-isomaltase complex and the human lysosomal alpha glucosidase'. European Journal of Biochemistry, 202 :657-664. [Details]
Kinsella, BT. & Cantwell, BA.; (1991) 'Analysis of the expression and secretion of the Candida tsukubaensis alpha glucosidase gene in the yeast Saccharomyces cerevisiae'. Yeast, 7 :445-454. [Details]
Kinsella, BT. & Maltese, WA.; (1991) 'Rab GTP-Binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif'. Journal of Biological Chemistry, 266 :8540-8544. [Details]
Kinsella, BT., Erdman, RA. & Maltese, WA.; (1991) 'Carboxyl-terminal isoprenylation of the ras-related GTP-Binding proteins encoded by rac1, rac2 and ralA. ('. Journal of Biological Chemistry, 266 :9786-9894. [Details]
Kinsella, BT., Erdman, RA. & Maltese, WA.; (1991) 'Post translational modification of p21H-ras by Farnesyl versus Geranylgeranyl isoprenoids is determined by the C-terminal amino acids'. Proceedings of the National Academy of Sciences, 88 :8934-8939. [Details]
Kinsella, BT., Larkin, A., Bolton, M. & Cantwell, BA.; (1991) 'Molecular cloning and characterization of a Candida tsukubaensis alpha glucosidase gene in the yeast Saccharomyces cerevisiae'. Current Genetics, 20 :45-52. [Details]
Kinsella, BT. & Maltese, WA.; (1990) 'Isoprenylation of the ras-related GTP-Binding proteins rac1, rac2 and ralA'. Journal of Cell Biology, 111 :101-104. [Details]
Kinsella, BT. & Doonan, S.; (1986) 'Nucleotide sequence of a cDNA coding for mitochondrial fumarases from human liver'. Bioscience Reports, 6 :921-930. [Details]
Kinsella, BT. & Doonan, S.; (1986) 'Putative precursors of rat liver cytosolic and mitochondrial fumarases'. Biochemical Society Transactions, 13 :712-713. [Details]
 

Conference Publications

Turner EC, Mulvaney EP, Reid HM & B.T. Kinsella BT. ; (2011) The human prostacyclin receptor contains a novel Rab11 binding domain that is regulated by . In: The FASEB Journal eds. Experimental Biology 2011 Washington DC, , 09-APR-11 - 13-APR-11 , pp.25-628.8 Available Online [Details]
Mulvaney EP, Reid HM & B.T. Kinsella BT. ; (2011) Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A2 receptor Prospects and Challenges for Therapeutic Targeting of Epoxyeicosanoids Minisymposium at Experimental Biology 2011 Washington DC, , 09-APR-11 - 13-APR-11 [Details]
Mulvaney EP, Reid HM & B.T. Kinsella BT. ; (2011) Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A2 receptor . In: FASEB J eds. Experimental Biology 2011 Washington DC, , 09-APR-11 - 13-APR-11 , pp.25-1008.1 Available Online [Details]
Reid HR, Mulvaney EP. Turner EC & Kinsella BT. ; (2010) Characterization of a novel Rab11 binding domain (RBD) within the human prostacyclin receptor that is regulated by palmitoylation . In: FASEB J. 2010. 24:771.9 eds. Experimental Biology 2010, Anaheim, CA, USA. April 24th ¿ 28th 2010 Anaheim, CA, USA, , 24-APR-10 - 28-APR-10 [Details]
B. Therese Kinsella; (2010) Biochemistry of the Prostacyclin Receptor Bioactive Lipids: Biochemistry and Diseases. Keystone Symposia on Molecular and Cellular Biology Kyoto, Japan, , 06-JUN-10 - 11-JUN-10 [Details]
Reid HM, Wikström K, O'Keeffe MB, Hill M, English KA, Mulvaney EP, Kinsella BT.; (2009) Agonist-induced trafficking of the human prostacyclin receptor is regulated by members of the Rab GTPase family. Identification of a putative Rab11a binding domain The Dynamic Cell joint meeting of the Biochemical Society & British Society for Cell Biology Appleton Tower, University of Edinburgh, UK, , 01-APR-09 - 04-APR-09 [Details]
Mulvaney EP, Reid HM & Kinsella BT.; (2009) Agonist-induced trafficking of the human prostacyclin receptor is regulated by members of the Rab GTPase family. Identification of a putative Rab11a binding domain Advancing Molecular Bioscience, Biochemical Society (Irish Area Section Annual Meeting 2009) Conway Institute, UCD, , 13-NOV-09 [Details]
B. Therese Kinsella; (2008) ·Expression and intracellular signalling by the TPa and TPb isoforms of the human thromboxane A2 receptor Genome Instability and Cancer, Biochemical Society (IAS) Focused Meeting, National University of Ireland, Galway, Ireland Galway. Ireland, , 04-DEC-08 [Details]
T. Kinsella.; (2008) Expression and intracellular signalling by the TPa and TPb isoforms of the human thromboxane A2 receptor Biochemical Society (IAS) Gold Medal Lecture, Presented that the Genome Instability and Cancer, Biochemical Society (IAS) Focused Meeting, National University of Ireland, Galway, Ireland [Details]
Katarina Wikström, David J. Kavanagh, Helen M. Reid & B. Therese Kinsella. ; (2008) Differential Regulation of RhoA-mediated Signaling by the TPa and TPb isoforms of the human Thromboxane A2 Receptor Keystone Symposia Conference G protein-coupled receptors:  New insights in Function, Regulation and Clinical Application.  INEC-Irelands National Events & Conference Centre, Killarney, Co. Kerry, Ireland [Details]
Helen M. Reid & B. Therese Kinsella.; (2008) Palmitoylation of the TPb isoform of the human thromboxane A2 receptor: Implications for Receptor Trafficking Experimental Biology 2008, San Diego Convention Center, San Diego, USA [Details]
Helen M. Reid, Martina B. O¿Keeffe, Karol English & B. Therese Kinsella. ; (2008) Role of Rab5 in Agonist-Induced Internalization of the human Prostacyclin Receptor Keystone Symposia Conference G protein-coupled receptors:  New insights in Function, Regulation and Clinical Application.  INEC-Ireland National Events & Conference Centre, Killarney, Co. Kerry, Ireland [Details]
Helen M. Reid, Martina B. O¿Keeffe, Karol English & B. Therese Kinsella. ; (2008) Role of Rab5 in Agonist-Induced Internalization of the human Prostacyclin Receptor Moderated poster, presented at Conway Institute Annual Festival of Research [Details]
Katarina Wikström, David J. Kavanagh, Helen M. Reid & B. Therese Kinsella. ; (2008) Differential Regulation of RhoA-mediated Signaling by the TPa and TPb isoforms of the human Thromboxane A2 Receptor Conway Institute Annual Festival of Research [Details]
Helen M. Reid & B. Therese Kinsella. ; (2007) Palmitoylation of the TPb isoform of the human thromboxane A2 receptor: Implications for Receptor Trafficking Science Foundation of Ireland, Science Summit [Details]
David J. Kavanagh & B.Therese Kinsella.; (2007) Functional characterisation of the a and b isoforms of the human Thromboxane ((TX) A2 receptor Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin [Details]
Karol English & B.Therese Kinsella. ; (2007) Application of the Yeast Two Hybrid System to Identify Novel Protein Interactants of the human Prostacyclin Receptor (IP) Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin [Details]
Helen M. Reid & B. Therese Kinsella; (2007) Palmitoylation of the TPbeta isoform of the human thromboxane A2 receptor LifeSciences2007 Glasgow, UK, , 09-JUL-07 - 12-JUL-07 [Details]
Anne-Marie Gannon & B. Therese Kinsella; (2006) Molecular Characterisation of Promoter 1 of the Human Thromboxane A2 Receptor Gene Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Kinsella BT.; (2004) Novel Mechanisms of Intracellular Signalling by the prostacyclin receptors Department of Biochemistry National University of Galway (NUIG), Galway, , 26-MAR-04 [Details]
Reid HM and Kinsella BT.; (2004) Investigation of the effect of nitric oxide on signalling by the  and  isoforms of the human thromboxane A2 receptor Experimental Biology 2004 Washington D.C., U.S.A, [Details]
Kelley-Hickie LP and Kinsella BT; (2004) EP1 -induced cross-desensitisation of the alpha () and beta () isoforms of the human Thromboxane A2 receptor Experimental Biology 2004 Washington DC, USA, [Details]
Kelley-Hickie LP and Kinsella BT; (2004) Prostaglandin (PG)E2- and PGF2alpha -induced cross -desensitization of the alpha and beta isoforms of the human Thromboxane A2 receptor BioScience 2004, From Molecules to Organisms, SECC Glasgow, UK, , 18-JUL-04 - 22-JUL-04 [Details]
Kelley-Hickie LP and Kinsella BT; (2004) Prostaglandin (PG)E2- and PGF2 -induced cross -desensitization of the alpha () and beta () isoforms of the human Thromboxane A2 receptor Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Reid HM and Kinsella BT.; (2004) Investigation of the effect of nitric oxide on signalling by the alpha and beta isoforms of the human thromboxane A2 receptor Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Reid HM and Kinsella BT; (2004) Investigation of the effect of nitric oxide on signalling by the alpha and beta isoforms of the human thromboxane A2 receptor BioScience 2004, From Molecules to Organisms, SECC Glasgow, UK, , 18-JUL-04 - 22-JUL-04 [Details]
O' Meara SJ & Kinsella BT.; (2003) Investigation into the effects of a statin inhibitor of HMG-CoA reductase on prostacyclin receptor function in vivo Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Kinsella BT.; (2003) Intracellular Signalling by the prostacyclin receptors: Basic mechanisms and novel insights Division of Biochemistry and Molecular Biology Davidson Building, Glasgow, U. K, , 10-NOV-03 [Details]
Reid HR & Kinsella BT.; (2003) Investigation of the effect of Nitric Oxide on signalling by the  and  isoforms of the human thromboxane A2 receptor Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Coyle AT, Miggin SM & Kinsella BT; (2003) Characterization of the 5' untranslated regions of the human thromboxane A2 receptor (TP) and  isoform mRNAs. Differential promoter utilization by the TP isoform transcripts Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Kinsella, BT; (2002) Intracellular signaling by prostacyclin receptors Department of Biochemistry University College Cork, [Details]
Kelley, LP & Kinsella, BT.; (2002) Prostaglandin D2 receptor (DP)-mediated desensitization of the  isoform of the human thromboxane A2 receptor Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Lawler, OA & Kinsella, BT. ; (2001) The effects of Lovastatin and Cerivastatin on signaling by the prostacyclin receptor Experimental Biology 2001 Orlanda, Florida, [Details]
Kelley, LP & Kinsella, BT. ; (2001) Prostaglandin D2 receptor (DP)-mediated desensitisation of the  isoform of the human thromboxane A2 receptor Experimental Biology 2001 Orlanda, Florida, [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Lawler, OA & Kinsella, B.T. ; (2001) The effects of Lovastatin and Cerivastatin on signaling by the prostacyclin receptor Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Miggin, SM & Kinsella, B.T. ; (2001) Activation of the MAPK cascades through the human thromboxane A2 receptor  and  isoforms Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Kelley, LP & Kinsella, BT.; (2001) Prostaglandin D2 receptor (DP) - mediated desensitisation of the  isoform of the human thromboxane A2 receptor Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Kinsella, BT.; (2001) Vascular Hemostasis, A Biochemist's Perspective. Royal Irish Academy Medal Lecture in Biochemistry Biochemical Society Dublin, [Details]
Miggin, SM & Kinsella, BT.; (2001) MAPK activation through the human thromboxane A2 receptor  and  isoforms British Pharmacological Society Dublin, [Details]
Lawler, OA & Kinsella, BT.; (2001) The effects of the statins on prostacyclin receptor signalling British Pharmacological Society Dublin, [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells British Pharmacological Society Dublin, [Details]
Freeman JE., McMahon, B., Godson C., and Kinsella, BT.; (2001) Characterisation of thromboxane A2 and lipoxin A4 signalling in human mesangial cells Irish Nephrological Society AGM Royal College of Physicians of Ireland, [Details]
Miggin, SM & Kinsella, BT.; (2001) Thromboxane A2 mediated MAPK activation through the human thromboxane A2 receptor  and  isoforms Experimental Biology 2001 Orlanda, Florida, [Details]
Kelley, LP & Kinsella, BT.; (2000) Prostaglandin D2 receptor (DP) - mediated desensitization of the alpha isoform of the human thromboxane A2 receptor G protein coupled receptor 2000 Symposium Boston, MA, [Details]
Miggin, S. and Kinsella, BT.; (1998) Differential expression of the h. thromboxane A2 receptor isoforms Experimental Biology 98 San Francisco, CA, [Details]
Walsh, M-T. & Kinsella, BT; (1998) Characterisation of the role of N-linked glycosylation in expression of the h. thromboxane A2 receptor Experimental Biology 98 San Francisco, CA, [Details]
Lawler O & Kinsella, BT.; (1998) Analysis of the cell signalling properties of the prostacyclin receptor NATO and FEBS sponsored research conference entitled: Molecular Mechanisms of Transcellular Signalling : From Membrane Receptors to Transcription Factors Island of Spetsai Greece, [Details]
Walsh, M-T & Kinsella, BT. ; (1998) The role of N-linked glycosylation in expression and signalling of the thromboxane A2 receptor isoforms Signal Transduction Pathways in Platelets and Vessel Cells: (1998) Fundamental Mechanisms to Pathology Research Conference Faculte de Medecine Lariboisiree, Saint Louis, Paris, France, [Details]
Lambkin, I., Walsh, M., O'Mahony, D.J. & Kinsella. BT; (1997) Molecular identification and characterisation of peptide sequences from phage display libraries which bind to the human thromboxane A2 receptor isoform Experimental Biology 97 New Orleans, LA, [Details]
Walsh, M.T & Kinsella, BT. ; (1997) A potential role for N-linked glycosylation in expression of the human thromboxane A2 receptor Febs Special Meeting on Cell Signalling Mechanisms Amsterdam, Netherlands, [Details]
Kinsella, BT., FitzGerald, GA. & O'Mahony, DJ.; (1995) The isoprostane 8-epi-prostaglandin F2 induces elevations in intracellular calcium by activation of the cloned thromboxane A2 receptor Experimental Biology 95TM Atlanta, Georgia, USA, [Details]
Kinsella, B.T., Erdman, R.A., Sheridan, K.M. & Maltese, W.A.; (1995) Lipid modification of Low Molecular Mass GTP Binding Proteins The First European Congress of Pharmacology, Federation of European Pharmacological Societies Milan, Italy, [Details]
Lambkin, I., Cagney, G., Kinsella, BT. & O'Mahony, DJ; (1995) Selection of novel Thromboxane A2 receptor binding peptides from random phage display libraries International Biochemical Society Meeting University College Dublin, Ireland, [Details]
Lambkin, I., Cagney, G., Kinsella. BT. & O'Mahony, DJ.; (1995) Identification of peptide mimetics from phage display libraries which bind to recombinant forms of the human thromboxane A2 receptor International Meeting of the Controlled Release Society Trinity College, Dublin, [Details]
Lambkin, I., Cagney, G., Kinsella. BT. & O'Mahony, DJ.; (1995) Selection of novel Thromboxane A2 receptor binding peptides from random phage display libraries International Meeting of the Controlled Release Society Trinity College, Dublin, [Details]
O'Mahony, D.J.; Kinsella, BT. & FitzGerald, GA.; (1994) Sequence polymorphism in the gene coding for the human thromboxane A2 receptor 9th International Conference on Prostaglandins and Related Compounds Florence, Italy, [Details]
Kinsella, BT., O'Mahony, DJ. & FitzGerald, GA.; (1994) Regulated expression of the gene coding for the human thromboxane A2 receptor 9th International Conference on Prostaglandins and Related Compounds Florence, Italy, [Details]
FitzGerald, G.A.; Lawson, J.; Pratico, D.; Delanty, N.; Fitzgerald, D. & Kinsella, BT; (1993) Molecular Mechanism of action of thromboxane A2 and the isoprostane 8-epi-PGF2alpha on platelets and the vessel wall 1st International Congress of the International Society for the Fatty acids and Lipids, from Cell Biology to Human Disease [Details]
Kinsella, BT., O'Mahony, DJ. &FitzGerald, GA.; (1993) Regulation of the thromboxane receptor by phosphorylation in vivo 35th Annual Meeting of The American Society of Hematology St Louis, [Details]
FitzGerald, G.A., O'Mahony, D.J., Kinsella, BT., Moran, N. & Lawson, JA.; (1993) Cellular activation by thromboxane A2 3rd International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury Washington, DC, [Details]
Kinsella, BT.; (1992) G Protein diversity in human blood cells The European Community Human Genome Mapping Programme Munich, Germany, [Details]
Knaus UG, Heyworth PG, Kinsella BT et al.; (1992) Purification and characterization of Rac2 - A cytosolic GTP binding-protein that regulated human neutrophil NADPH oxidase CIRCULATION 86 (4) [Details]
Kinsella, B.T. & Maltese, W.A. ; (1991) Rab GTP-Binding proteins with three different carboxyl-terminal cysteine motifs are modified by 20-carbon isoprenoids in vivo The American Society for Biochemistry and Molecular Biology; Fall Symposium on the Biological Significance of Lipid Modification of Proteins Keystone, CO, USA, [Details]
Kinsella, BT. & Maltese, WA.; (1990) Isoprenylation of the ras-related GTP-Binding proteins rac1, rac2 and H-ral 30th Annual Meeting of the American Society for Cell Biology San Diego, USA, [Details]
Miggin SM & Kinsella BT.; (2003) Palmitoylation of the human prostacyclin receptor; Functional implications of Isoprenylation and Palmitoylation Experimental Biology 2003, San Diego, California San Diego, USA, [Details]
Kinsella BT, Lawler OA & Miggin SM.; (2003) Investigation of the mechanisms of G-protein: Effector Coupling by the Human and Mouse Prostacyclin Receptors Experimental Biology 2003, San Diego, California, April 2003 San Diego, USA, [Details]
Coyle AT, Miggin SM & Kinsella BT.; (2003) Characterization of the 5 untranslated regions of the human thromboxane A2 receptor (TP)a and b isoform mRNAs. Differential promoter utilization by the TP isoform transcripts Experimental Biology 2003, San Diego, California, April 2003 San Diego, USA, [Details]
Kelley, LP & Kinsella, BT. Presented to the Abstract:; (2001) Desensitisation of the a isoform of the human thromboxane A2 receptor by prostaglandin D2 receptor (DP) British Pharmacological Society, Dublin, July 2001 [Details]
Miggin, SM & Kinsella, BT.; (2003) MAPK activation through the human thromboxane A2 receptor a and b isoforms British Pharmacological Society [Details]
Hanson, J., Dogné, J-M., Ghiotto, J., Neven, P., Kelley, L.P., Kinsella, B.T. & Pirotte, B.; (2006) Pharmacological evaluation of TP receptor antagonists characterized by differential activity on alpha and beta isoforms IUPHAR International Congress in Pharmacology Beijing, China, [Details]
Coyle, A.T. and Kinsella, B.T.; (2005) Characterization of promoter 3 of the human thromboxane A2 receptor gene Experimental Biology 2005 San Diego, CA, USA, [Details]
     

Website article

B. Therese Kinsella & Elizebeth C. Turner; (2010) Researchers discover how oestrogen protects against heart disease. HRB Website: Website article Available Online [Details]

Newspaper Articles

Nataya Anderson about the work of BT Kinsella & EC Turner; (2010) Estrogen's use as a protector against cardiovascular disease. Irish Medical Times: Newspaper Articles Available Online [Details]
*; (2003) Dublin doctor gets 1M cardiovascular research grant. Newspaper Articles [Details]
*; (2003) Drug Research; Cross fertilisation in the Lab. Newspaper Articles [Details]
*; (2003) Observing the delicate balancing act of blood flow. Newspaper Articles [Details]
*; (2000) Scientist rewarded for her work with presigous medal. Newspaper Articles [Details]
*; (2000) Shedding light on the link between cholesterol and proper haemostasis. Newspaper Articles [Details]
   

Reports

*; (2003) Wellcome Trust Programme Grant Awarded. Reports [Details]
       

Abstract

Hanson J, Dogne JM, Moray AL, Ghiotto J, Kelley LP, Kinsella BT, Pirotte B.; (2006) Pharmacological evaluation of TP receptor antagonists on alpha and beta receptor isoforms. Abstract [Details]
Kinsella BT, Lawler OA & Miggin SM; (2003) Investigation of the mechanisms of G-protein: Effector Coupling by the Human and Mouse Prostacyclin Receptors. Abstract Available Online [Details]
Kelley, LP & Kinsella, BT.; (2001) Desensitisation of the  isoform of the human thromboxane A2 receptor by prostaglandin D2 receptor (DP). Abstract [Details]
Miggin, SM & Kinsella, BT. ; (2001) Thromboxane A2 mediated MAPK activation through the human thromboxane A2 receptor  and  isoforms. Abstract [Details]
Miggin, S. and Kinsella, BT.; (1998) Differential expression of the h. thromboxane A2 receptor isoforms. Abstract [Details]
Walsh, M-T. & Kinsella, BT.; (1998) Characterisation of the role of N-linked glycosylation in expression of the h. thromboxane A2 receptor. Abstract [Details]
Lambkin, I., Walsh, M., O'Mahony, D.J. & Kinsella. BT; (1997) Molecular identification and characterisation of peptide sequences from phage display libraries which bind to the human thromboxane A2 receptor isoform. Abstract [Details]
Kinsella, BT., FitzGerald, GA. & O'Mahony, DJ.; (1995) The isoprostane 8-epi-prostaglandin F2 induces elevations in intracellular calcium by activation of the cloned thromboxane A2 receptor. Abstract [Details]

Invited Lectures

Kinsella, BT; (2002) Intracellular signalling by prostanoid receptors: novel insights. University College Dublin: Invited Lectures [Details]
Kinsella, BT; (2000) Vascular Hemostasis, A Biochemist's Perspective. Dublin: Invited Lectures [Details]
                                                   

Review Articles

Lawler OA & Kinsella, BT ; (2000) Vascular homeostasis - a cholesterol balancing act. Published in The Irish Scientist. (2000) 8, 201-202. Review Articles [Details]
Kinsella, B.T.; (1999) Cardiovascular disease - the missing link. Published in The Irish Scientist. (1999) 7, 176 -177. Review Articles [Details]
Smith, S.D., O'Mahony, D.J., Kinsella, BT. & Rothblum, L.I. ( ; (1993) Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF.Gene Expression, 3, 229-236.S. Review Articles [Details]
Lambkin, I., Cagney, G., Kinsella, BT. & O'Mahony, DJ.; (1991) Identification of peptide mimetics from phage display libraries which bind to recombinant forms of the human thromboxane A2 receptor. (1997). Journal of Controlled Release, 46 (1,2), 190 -191. Review Articles [Details]
Kinsella, BT. & Maltese, WA.; (1990) Isoprenylation of the ras-related GTP-Binding proteins rac1, rac2 and ralA. (1990) J.Cell. Biol. 111, 101 104. Review Articles [Details]
Kinsella, BT. & Doonan, S.; (1986) · Nucleotide sequence of a cDNA coding for mitochondrial fumarases from human liver. (1986)BioScience Reports, 6, 921-930. Review Articles [Details]
 

Educational Articles

Vascular Hemostasis, A Biochemists Perspective. Kinsella, BT. ; (2001) The Irish Scientist. Educational Articles [Details]

Invited Review Articles

Kinsella, BT. and O'Mahony, DJ.; (1994) Lipid Modification of G proteins. (1994) Trends in Cardiovascular Medicine, 4, 27-34. Invited Review Articles [Details]
 

Research

Research Interests

  • The key area of my research & innovation and scholarly activity relates to the role of the arachidonic acid-derived prostanoids thromboxane and prostacyclin in human health and disease.

    Cardiovascular (CV) disease is a leading cause of morbidity and premature mortality globally.    The prostanoids, which include the prostaglandins (PGs) and thromboxanes, are potent lipid mediators that regulate diverse processes within the human body including within the CV system.  More specifically, the prostanoids thromboxane (TX) A2 and prostacyclin (or PGI2) play key, yet opposing roles, in haemostasis and vascular tone and regulate a range of other physiologic responses in the renal and pulmonary systems.  Imbalances in the levels of TXA2 or prostacyclin, and/or of their respective synthases or receptors are implicated in several CV diseases, including atherothrombosis, myocardial infarction and restenosis, as well as in bronchial asthma, chronic obstructive pulmonary disease and glomerulonephritis, a leading cause of renal failure.  Critically, recognition of the importance of TXA2 and prostacyclin to vascular integrity was highlighted in clinical trials whereby certain COXIBS, selective cyclooxygenase (COX) 2 inhibitors, were found to impair prostacyclin generation without significantly altering TXA2 levels, predisposing patients to increased risk of thrombosis and other adverse CV episodes.  Hence, gaining detailed knowledge of the modes of action, signalling and regulation of TXA2 and prostacyclin are central to understanding their contribution to the diverse disease processes in which they are implicated, be it for preventative-, diagnostic- and/or therapeutic-purposes.  Indeed, in recent years, there is also an abundance of emerging evidence, including from several longitudinal studies, showing strong clinical correlation between the role of certain prostanoids, particularly TXA2, in increasing the risk of many common cancers.

    Both TXA2 and prostacylin signal through their cognate cell surface receptors, both members of the G-protein coupled receptor (GPCR) superfamily.  While prostacyclin largely signals through the I Prostanoid receptor or, in short, the IP, TXA2 actually signals through two distinct T Prostanoid receptor (TP) isoforms, referred to as TPalpna and TPbeta.   Whilst the biologic significance of two TPs is not fully understood, they greatly add to the complexity of TXA2 responses in humans and there is substantial evidence from our research that TPalpha and TPbeta have distinct (patho)physiologic roles.  The main scientific focus of my research group is to elucidate the molecular mechanisms of TXA2 and prostacyclin-mediated intracellular signalling & function and to identify the key factors determining the transcriptional regulation of the TP and IP genes in humans.  The overall goal of these studies has been to obtain a detailed, mechanistic understanding of the role of TXA2 and prostacyclin in haemostasis & vascular tone and to elucidate their contributory role in CV & neoplastic disease.   From a translational view point, our laboratory also has an innovative drug-discovery programme for the development of small-molecule antagonists of TPalpna/TPbeta for use as anti-thrombotic or anti-cancer therapeutic agents. 

    The research activities in Prof. B. Therese Kinsella's group have been supported through successive grant awards from the Wellcome Trust, Health Research Board, Irish Cancer Society, Irish Heart Foundation, Science Foundation of Ireland and the European Union.  Furthermore, the innovative drug discovery/drug development programme has been funded through successive commercialisation-type grants awarded by Enterprise Ireland under the auspices of their Technology Development/ Commercialisation-funded schemes.  The outputs of this work has led to early discussions with life-science venture capital funds on the potential for spin out of a new biotechnology company to further develop our novel TP antagonist drug leads. 

     

Teaching

Teaching Philosophy

My philosophy of teaching is to ensure that students obtain a fundamental understanding of the major underlying principles of the subject. I appeal to the student's own ability to understand the subject and, from there, to empower them to discover for themselves the fascinations of scientific research and endeavour.
 

Enhancement of Teaching

I am currently involved in delivering teaching modules across all levels of the undergraduate academic spectrum including at Level 1 (SCI10010, Principles of Scientific Enquiry), Level 2, (BMOL20020, Biomolecular Laboratory Skills; Class size, 2012/13, 268) Level 3 (Molecular Basis of Disease; Class size, 2012/13, ~170) and Level 4 (BIOC40030, Advanced Cell Signalling; Class size, 2012/13, 45). In addition, I am also involved in teaching and research at the postgraduate level, including in designing new programmes and modules (BIOC40170, Pharmacology & Drug Development; Class size, 2012/13, 20) delivered through the SBBS taught M.Sc programmes in Biotechnology and in Biotechnology & Business. These modules are implemented and taught at the highest level incorporating, where relevant, material at the cutting edge of scientific developments; the courses have been so designed to incorporate the use of videos, one-to-one or group-based projects, and/or various internet-based learning modalities/advanced tools to demonstrate new/difficult concepts. Moreover, the practicals and problem-solving sessions associated with these modules have been especially designed/enhanced to fully complement the lecture material, enhancing student learning, and are viewed as popular assets by the students, bridging the important gap between the academic and practical-principles of biochemistry, biotechnology, pharmacology and related biomolecular/biomedical science. As a measure of the success of these courses, as attested by the end of module surveys, student feedback has always been consistently high, despite the fact that they mainly deal with subject matter in the area of Biochemistry, a science discipline that can often be viewed as difficult by other student groups.

Review and Enhancement of Curriculum

I have made significant contributions towards curriculum review and development, not just in the modules I currently deliver but also throughout my years as a UCD academic where I have acted at every level including as lecturer, module/unit co-ordinator and at committee level in driving curriculum development & reform. For example, in the past, I was a member of the curriculum review committee of the Ist year Physiotheraphy/Radiography course, culminating in extensive changes to the Biochemistry module content, mode of delivery and assessment. Similarly, I was involved in designing and implementing the 'Systems Based-Medical Curriculum' first introduced to medical undergraduates in 2002. Furthermore, I acted as unit director of several undergraduate units delivered to science (BIOC3004; BIOC3005), physio/radiotherapy and medical students. More recently, since formation of the School of Biomolecular & Biomedical Science (SBBS) in 2005, bringing together the Departments of Biochemistry, Pharmacology, Microbiology and, in part, Physiology, I have served as Deputy Head of SBBS. In this position, I have played a key role in driving curriculum review at the subject, cross-discipline, school and university-wide levels. In that time, I have also played a specific role in designing several new modules in whole, including BMOL30020 (Molecular Basis of Disease), BMOL30030 (Control of Gene Expression), BIOC40030 (Advanced Cell Signalling), BIOC40170 (Pharmacology & Drug Development), or in part including BMOL10020 (Human Disease), SCI10010 (Scientific Enquiry) and BMOL20020 (Biomolecular Laboratory Skills). Additionally, in that time, SBBS has overseen the introduction of 2 new disciplines (neuroscience and genetics), as well as new taught programmes at both the undergrad, including denominated and non-denominated entry, and postgrad levels, including new M.Sc programmes. Central to all of the curriculum review and enhancement that I have been involved in has been active consideration of stakeholder involvement, feedback and market demands.

Developing as a Teacher

I have used a number of approaches to improve the quality of my teaching. On a more formal basis, this has included the completion of a number of courses to improve my technical and oral presentation skills and through extensive revision of the courses, mainly along the principle of keeping the course material as up-to-date as possible, responding to student feedback and customising the course to meet specific student/class requirements, be it at the module or programme level. I regularly participate in workshops on education and teaching organised by professional societies including the Biochemical Society, and by various other international societies, such as those presented annually at Experimental Biology, through the auspices of the American Society of Biochemistry and Molecular Biology and the American Society of Pharmacology and Experimental Therapeutics. My attendance at these workshops and conferences have greatly helped me to formulate my philosophy of teaching which is generally along the principle that scientific advancements are, on the whole, through discovery; therefore, I believe that scientific learning in the classroom must engage the students in formative thinking bringing them along the path of understanding and discovery, rather than just a presentation of the established facts.

Innovation & Leadership

Since appointed to UCD (1992), I have undertaken a number of important roles with respect to teaching innovation and leadership both within Biochemistry and, more recently, SBBS. At subject/cross-discipline level, I have been involved in the design, delivery and co-ordination of several new modules as well as, at committee level, over-seeing the introduction of several undergrad and postgrad taught programmes within SBBS. At the national level, I am a member of the Science Education Committee, Royal Irish Academy.

Collaborators

Internal Collaborators

  • Dr. Helen Reid,
  • Prof. William Gallagher, SBBS, UCD.
  • Prof. William Watson, SBBS, UCD,
  • Dr. Orina Belton, SBBS, UCD
  • Professor Patrick Guiry, CSCB, UCD

External Collaborators

Professor Olivier Kocher, Harvard University,
Professor Shuh Narumiya, Kyoto University,
Professor DatViewotai Nie, Southern Illinois University,
Dr Amir Khan, Trinity College Dublin,