UCD Research: Biomolecular & Biomed Science

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Professor William Gallagher BSc PhD MI BIOL

Contact Details

Title	Associate Professor
Address	School of Biomolecular & Biomed Science Conway Institute Belfield Dublin 4
Telephone:	Ext. 6743
Email:	ei.dcu@rehgallag.mailliw

Biography:

Professor William Gallagher BSc PhD CBiol MSB

Prof William Gallagher is an Associate Professor of Cancer Biology in the UCD School of Biomolecular & Biomedical Science and a UCD Conway Institute Fellow. His primary research interests are in the areas of cancer biology and molecular therapeutics.

A major focus of Prof. Gallagher's research work is the identification and validation of candidate biomarkers of breast cancer and melanoma, with particular emphasis on translation of transcriptomic and proteomic datasets into clinically relevant assays. In addition, his team utilises lentiviral-based approaches to investigate the functional relevance of candidate tumour progression-associated genes at both in vitro and in vivo levels, as well as engages in preclinical evaluation of novel anti-cancer agents.

Prof. Gallagher is Co-ordinator of the Target-Melanoma programme, which received €1.73 million in funding as part of the Marie Curie Industry-Academia Partnerships and Pathways Programme in 2009.

Related links
• Prof William Gallagher: Full Biography including a complete list of his research publications.
• `Target Melanoma' research to explore new potential targets for skin cancer therapy
• UCD Conway fellows among cluster for cancer-focused strategic research
• UCD Conway Fellows host prestigious EMBO conference in cancer proteomics

Biographical sketch
Prof. Gallagher originally graduated from the Department of Biochemistry, UCD in 1993 with a 1st Class Joint Honours degree in Molecular Genetics and Biochemistry. Subsequently, he obtained a PhD in Molecular and Cellular Biology from the Cancer Research UK Beatson Laboratories in Glasgow. In 1997, he moved to Paris to undertake a Marie Curie Individual Fellowship at Rhone-Poulenc Rorer (currently Sanofi-Aventis). Afterwards, he returned to Ireland upon receipt of an Enterprise Ireland Post-Doctoral Fellowship (1999-2000) and, subsequently, a Marie Curie Return Fellowship (2000-2001). In 2001, he was employed in a permanent capacity as College Lecturer at UCD within the former Department of Pharmacology. In 2005, he was appointed Senior Lecturer within the UCD School of Biomolecular and Biomedical Science and was promoted to Associate Professor of Cancer Biology in 2006. In September 2009, Prof. Gallagher took up the position of Vice-Principal of Research and Innovation at the UCD College of Life Sciences. He is also a Conway Fellow at the UCD Conway Institute. In 2007, he co-founded OncoMark Ltd., which is a private company centred on the development and application of biomarker panels and associated technologies, on both tissues and biological fluids (www.oncomark.com). A major focus of Prof. Gallagher's research work is the identification and validation of candidate biomarkers of breast cancer and melanoma, with particular emphasis on translation of transcriptomic and proteomic datasets into clinically relevant assays. In addition, his team utilises lentiviral-based approaches to investigate the functional relevance of candidate tumour progression-associated genes at both in vitro and in vivo levels, as well as engages in preclinical evaluation of novel anti-cancer agents.

Prof. Gallagher currently co-ordinates an FP6 Marie Curie Transfer of Knowledge Industry-Academia Partnership Programme, Target-Breast (www.targetbreast.com), which involves 3 academic and 2 industrial partners across 3 EU countries (running from 2006-2010). In addition, he co-ordinates an analogous FP7 Marie Curie Industry-Academia Partnership and Pathways Programme, Target-Melanoma, which involves 7 partners (5 academic/2industrial) across 5 EU countries and runs from 2009-2013. Prof. Gallagher is also co-PI of a major Science Foundation Ireland-funded Strategic Research Cluster, Molecular Therapeutics of Cancer (2009-2014). Prof. Gallagher has received a number of awards based on his research work to date, including the BACR/AstraZeneca Young Scientist Frank Rose Award in 2004 and the St. Luke's Silver Medal Award in 2008. Prof. Gallagher has had productive collaborative interactions with a variety of other industrial partners throughout his research, and has filed multiple patents.

Research Interests

My primary research interests are in the areas of cancer biology and molecular therapeutics. I have a key research programme focusing on the role of an emerging family of extracellular matrix proteins, known as the fibulins, in cancer. In addition, our research team has been utilising a variety of functional genomic approaches for several years to provide global overviews of the molecular processes involved in tumour development and progression. In particular, we have been focusing on melanoma and breast cancer to yield new biomarkers and therapeutic targets. My research benefits from an extensive network of national and international collaborators, with our work activities often being at the chemistry-biology or basic science-clinical interface.

Book Chapters

Foley, R., Callanan, S., Gallagher, W., Cunningham, P.,; (2010) 'A Machine Learning System for Identifying Hypertrophy in Histopathology Images' In: Coyle, L. and Freyne, J (eds). Lecture Notes in Computer Science, Volume 6206 (AICS 2009). Berlin: Springer.

[DOI] [Details]

Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson, W., Cunningham, P. and Gallagher, W. ; (2008) 'Automated Image Analysis Approaches in Histopathology' In: Handbook of Research on Systems Biology Applications in Medicine. Hershey, Pennsylvania: IGI Global. [Details]

Cooney, H. C. M. and Gallagher, W. M.; (2011) 'Fibulins and their role in the ECM' In: Margareta M. Mueller and Norbert E. Fusenig (eds). Tumour-Associated Fibroblasts and Their Matrix: Tumor Stroma. Unknown: Spinger Science+Business Media B. V. [Details]

Collins, B. C., Lau, T. Y. K., Pennington, S. R., and Gallagher, W. M. ; (2011) 'Differential proteomics incorporating iTRAQ labelling and multi-dimensional separations' In: Jean-Charles Gautier (eds). Methods in Molecular Biology - Drug Safety Evaluation. N/A: Humana Press.

[DOI] [Details]

Lau, T. Y. K., Collins, B. C., Stone, P., Tang, N., Gallagher, W. M., and Pennington, S. R. ; (2011) 'Absolute quantification of toxicological biomarkers via multiple reaction monitoring' In: Gautier, J.-C (eds). Methods in Molecular Medicine - Drug Safety Evaluation. New York: Humana Press.

[Details]

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Peer Reviewed Journals

O'Connor, A.E.; McGee, M.M.; Likar, Y.; Ponomarev, V.; Callanan, J.J.; O'Shea, D.F. Byrne, A.T.; Gallagher, W.M; (2012) 'Mechanism of Cell Death Mediated by a BF2-Chelated Tetraarylazadipyrromethene Photodynamic Therapeutic'. International Journal of Cancer, 130 . [Details]

Lindsay, C. R., Lawn, S., Campbell, A. D., Faller, W. J., Rambow, F., Mort, R. L., Timpson, P., Li, A., Cammareri, P., Ridgway, R. A., Morton, J. P., Doyle, B., Hegarty, S., Rafferty, R., Murphy, I. G., McDermott, E. W., Sheahan, K., Pedone, K., Finn, A. J., Groben, P. A., Thomas, N. E., Hao, H., Carson, C., Norman, J. C., Machesky, L. M., Gallagher, W. M., Jackson, I. J., Van Kempen, L., Beermann, F., Der, C., Larue, L., Welch, H. C., Ozanne, B. W. Sansom, O. J. ; (2011) 'P-Rex1 is required for efficient melanoblast migration and melanoma metastasis'. Nature Communications, . [Details]

O'Neill A.J., Prencipe M., Dowling C., Fan Y., Mulrane L., Gallagher W.M., O'Connor D., O'Connor R., Devery A., Corcoran C., Rani S., O¿Driscoll L., Fitzpatrick J., R., Watson R.W.G. ; (2011) 'Characterisation and Manipulation of Docetaxel Resistant Prostate Cancer Cell Lines'. MOL CANCER, . [Details]

Johnston, O,Cassidy, H,O'Connell, S,O'Riordan, A,Gallagher, W,Maguire, PB,Wynne, K,Cagney, G,Ryan, MP,Conlon, PJ,McMorrow, T; (2011) 'Identification of beta 2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods'. Proteomics Clinical Applications, 5 :422-431. [DOI] [Details]

Dowling, DP,Miller, IS,Ardhaoui, M,Gallagher, WM; (2011) 'Effect of Surface Wettability and Topography on the Adhesion of Osteosarcoma Cells on Plasma-modified Polystyrene'. Biomaterials, 26 :327-347. [DOI] [Details]

Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM, Byrne A, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG; (2011) 'The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells'. Shock, . [Details]
DeNardo, DG,Brennan, DJ,Rexhepaj, E,Ruffell, B,Shiao, SL,Madden, SF,Gallagher, WM,Wadhwani, N,Keil, SD,Junaid, SA,Rugo, HS,Hwang, ES,Jirstrom, K,West, BL,Coussens, LM; (2011) 'Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy'. Cancer, 1 :54-67. [DOI] [Details]
Miller, IS,Lynch, I,Dowling, D,Dawson, KA,Gallagher, WM; (2010) 'Surface-induced cell signaling events control actin rearrangements and motility'. Journal of Biomedical Materials Research Part A, 93A :493-504. [DOI] [Details]
Mally A, Adler M, Hoffmann D, Ellinger-Ziegelbauer H, Hewitt P, Matheis K, Mulrane L, Gallagher WM, Callanan JJ, Suter L, Fountoulakis MM, Dekant W, ; (2010) 'Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies'. Toxicology Letters, 196 :1-11. [DOI] [Details]
Lau, TYK,Power, KA,Dijon, S,de Gardelle, I,McDonnell, S,Duffy, MJ,Pennington, SR,Gallagher, WM; (2010) 'Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression toward clinical verification'. Journal of Proteome Research, 5 :1450-1459. [DOI] [Details]
Faller, WJ,Rafferty, M,Hegarty, S,Gremel, G,Ryan, D,Fraga, MF,Esteller, M,Dervan, PA,Gallagher, WM; (2010) 'Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis'. Melanoma research, 20 :392-400. [DOI] [Details]
Gallagher WM, Miller IS, Lynch I, Dowling D, Dawson KA, ; (2009) 'Surface-induced cell signaling events control actin rearrangements and motility'. Journal of Biomedical Materials Research Part A, (NA). [DOI] [Details]
O'Riordan, A,Johnston, O,McMorrow, T,Wynne, K,Maguire, P,Hegarty, JE,McCormick, A,Watson, AJ,Cagney, G,Gallagher, WM,Ryan, MR; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics, 2 :1338-1348. [DOI] [Details]
Gallagher WM, Brennan DJ, Rexhepaj E, O'Brien SL, McSherry E, O'Connor DP, Fagan A, Culhane AC, Higgins DG, Jirstrom K, Millikan RC, Landberg G, Duffy MJ, Hewitt SM, ; (2008) 'Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer'. Clinical Cancer Research, 9 (NA):2681-2689. [DOI] [Details]
O Riordan A., Johnston O., McMorrow T., Wynne K., Maguire P., Hegarty J.E., McCormick A., Watson A.J., Cagney G., Gallagher W.M. and Ryan M.P. ; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (8):1338-1348. [Details]
Zagozdzon, R., Gallagher, W.M., Crown, J. ; (2011) 'Truncated HER2: implications for HER2-targeted therapeutics'. Drug Discovery Today, 16 (17-18):812-816. [Details]
Fitzgerald, K. T., Holladay, C. A., McCarthy, C., Power, K. A., Pandit, A., and Gallagher, W. M.; (2011) 'Standardization of models and methods used to assess nanoparticles in cardiovascular applications'. Small, 7 (6):705-717. [Details]
van der Meel, R., Symons, M. H., Kudernatsch, R., Kok, R. J., Schifflers, R. M., Storm, G., Gallagher, W. M., and Byrne, A. T.; (2011) 'The VEGF/Rho GTPase signalling pathway: a promising target for antiangiogenic and anti-invasion therapy'. Drug Discovery Today, 16 (5-6):219-228. [Details]
Maher, S. G., McDowell, D. T., Collins, B. C., Muldoon, C., Gallagher, W. M., and Reynolds J. V. ; (2011) 'Serum proteomic profiling reveals that pretreatment complement protein levels are predictive of esophageal cancer patient response to neoadjuvant chemoradiation'. Annals of Surgery, 254 (5):809-817. [Details]
Sernbo S., Gustavsson E., Brennan D.J., Gallagher W.M., Rexhepaj E., Rydnert F., Jirström K., Borrebaeck C.A., Ek S. ; (2011) 'The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation'. BMC Cancer, 11 . [Details]
Coward, J., Kulbe, H., Chakravarty, P., Leader, D. A., Vassileva, V., Leinster, D. A., Thompson, R., Schioppa, T., Nemeth, J. A., Vermeulin, J., Singh, N., Avril, N. E., Cummings, J., Rexhepaj, E., Jirstrom, K., Gallagher, W. M., Brennan, D. J., McNeish, I. A., Balkwill, F. R. ; (2011) 'Interleukin-6 as a therapeutic target in human ovarian cancer'. Clinical Cancer Research, 17 (18):6083-6096. [Details]
Gremel, G., Ryan, D., Rafferty, M., Lanigan, F., Hegarty, S., Lavelle, M., Murphy, I., Unwin, L., Joyce, C., Faller, W., McDermott, E.W., Sheahan, K., Ponten, F.,Gallagher W.M. ; (2011) 'Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma'. British Journal of Cancer, 105 (4):565-574. [Details]
O'Connor, A.E., Mc Gee, M.M., Likar, Y., Ponomarev, V., Callanan, J.J., O'shea, D.F., Byrne, A.T., Gallagher, W.M. ; (2011) 'Mechanism of cell death mediated by a BF(2) -chelated tetraaryl-azadipyrromethene photodynamic therapeutic: Dissection of the apoptotic pathway in vitro and in vivo'. International Journal of Cancer, . [Details]
Magnusson, K., de Wit. M., Brennan, D. J., Johnson, L. B., McGee, S. F., Lundberg, E., Naicker, K., Klinger, R., Kampf, C., Asplund, A., Wester, K., Gry, M., Bjartell, A., Gallagher, W.M., Rexhepaj, E., Kilpinen, S., Kallioniemi, O. P., Belt, E., Goos, J., Meijer, G., Birgisson, H., Glimelius, B., Borrebaeck, C. A., Navani, S., Uhlén, M., OʼConnor, D. P., Jirström, K., and Pontén, F. ; (2011) 'SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas'. American Journal of Surgical Pathology, 35 (7):937-948. [Details]
Brennan, D. J., Laursen, H., O'Connor, D., Borgquist, S., Uhlén, M., Gallagher, W. M., Ponten, F., Millikan, R. C., Ryden, L., and Jirstrom, K.; (2011) 'Tumor specific HMG-CoA reductase expression in primary pre-menopausal breast cancer predicts response to tamoxifen'. Breast Cancer Research, 13 (1). [Details]
Dasari, S., Chambers, M. C., Codreanu, S. G., Liebler, D. C., Collins, B. C., Pennington, S. R., Gallagher, W. M. and Tabb, D. L. ; (2011) 'Sequence tagging reveals unexpected modifications in toxicoproteomics'. Chemical research in toxicology, 24 (2):204-216. [Details]
Holladay, C., Power, K., Sefton, M., O'Brien, T., Gallagher, W. M., and Pandit, A. ; (2011) 'Functionalized scaffold mediated interleukin-10 gene delivery significantly improves survival rates of stem cells in vivo'. Molecular Therapy, 19 (5):969-978. [Details]
Devitt, E. J., Power, K. A., Lawless, M. W., Browne, J. A., Gaora, P. O., Gallagher, W. M., and Crowe, J. ; (2011) 'Early proteomic analysis may allow noninvasive identification of hepatitis C response to treatment with pegylated interferon α-2b and ribavirin'. European Journal of Gastroenterology & Hepatology, 23 (2):177-183. [Details]
Fitzpatrick, S. F., Tambuwala, M. M., Bruning, U., Schaible, B., Scholz, C. C., Byrne, A., O'Connor, A., Gallagher, W. M., Lenihan, C. R., Garvey, J. F., Howell, K., Fallon, P. G., Cummins, E. P., and Taylor, C. T. ; (2011) 'An intact canonical NF-kB pathway is required for inflammatory gene expression in pesponse to hypoxia'. Journal of Immunology, 186 (2):1091-1096. [Details]
Dahlman, A., Rexhepaj, E., Brennan, D. J., Gallagher, W. M., Gaber, A., Lindgren, A., Jirström, K., and Bjartell, A; (2011) 'Evaluation of the prognostic significance of MSMB and CRISP3 in prostate cancer using automated image analysis'. Modern Pathology, 24 (5):708-719. [Details]
O'Donovan, N. Byrne, A. T., O'Connor, A. E., McGee, S., Gallagher, W. M., and Crown, J.; (2011) 'Synergistic interaction between trastuzumab and EGFR/HER-2 tyrosine kinase inhibitors in HER-2 positive breast cancer cells'. Investigational New Drugs, 29 (5):752-759. [Details]
Brennan, D. J., O'Connor, D. P., Rexhepaj, E., Ponten, F., and Gallagher, W. M. ; (2010) 'Antibody-based proteomics: fast-tracking molecular diagnostics in oncology'. Nature reviews. Cancer, 10 (9):605-617. [Details]
Power, KA, Fitzgerald, KT and Gallagher, WM. ; (2010) 'Examination of cell-host-biomaterial interactions via high-throughput technologies: A re-appraisal'. Biomaterials, 31 (26):6667-6674. [Details]
van der Meel, R., Gallagher, W. M., Oliveira, S., O'Connor, A. E., Schiffelers, R., and Byrne, A. T; (2010) 'Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies'. Drug Discovery Today, 15 (3/4):102-114. [Details]
O'Neill K, Lyons SK, Gallagher WM, Curran KM, Byrne AT; (2010) 'Bioluminescent imaging: a critical tool in pre-clinical oncology research'. Journal of Pathology, 220 (3):317-327. [DOI] [Details]
Agnarsdottir, M, Sooman, L., Bolander, A., Strömberg, S., Rexhepaj, E., Bergqvist, M., Ponten, F., Gallagher, W.M., Lennartsson, J., Ekman, S., Uhlen, M., and Hedstrand, H. ; (2010) 'SOX10 expression in superficial spreading and nodular malignant melanomas'. Melanoma Research, 20 (6):468-478. [Details]
Rexhepaj, E., Jirstrom, K., O'Connor, D. P., O'Brien, S. L., Landberg G., Duffy, M. J., Brennan, D. J., and Gallagher, W. M. ; (2010) 'Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer'. BMC Cancer, 10 . [Details]
Ursini-Siegel, J., Cory, S., Zuo, D., Hardy, W. R., Rexhepaj, E., Lam, S., Schade, B., Jirstrom, K., Bjur, E., Piccirillo, C. A., DeNardo, D., Coussens, L. M., Brennan, D. J., Gallagher, W. M., Park, M., Pawson, T., Hallett, M. and Muller, W. J.; (2010) 'Receptor tyrosine kinase signaling in breast cancer cells inhibits the adaptive immune response to favor a pro-tumorigenic state'. Cancer Research, 70 (20):7776-7787. [Details]
Dash, B. C., Rethore, G., Monaghan, M., Fitzgerald, K., Gallagher, W.M, and Pandit, A; (2010) 'The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility'. Biomaterials, 31 (32):8188-8197. [Details]
Lanigan, F., Gremel, G., Hughes, R., Brennan, D. J., Martin, F., Jirström, K., and Gallagher, W. M.; (2010) 'Homeobox transcription factor Msx2 correlates with good prognosis in breast cancer patients and induces apoptosis in vitro'. Breast Cancer Research, 12 (4). [Details]
Whyte, J., Thornton, L., McNally, S., McCarthy, S., Lanigan, F., Gallagher, W. M., Stein, T., and Martin, F. ; (2010) 'PKCdelta regulates cell polarisation and proliferation restriction during mammary acinus formation'. Journal of Cell Science, 123 (19):3316-3328. [Details]
Ryan, D., Rafferty, M., Hegarty, S., Leary, P. O., Faller, W., Gremel, G., Bergqvist, M., Agnarsdottir, M., Strömberg, S., Kampf, C., Pontén, F., Millikan, R. C., Dervan, P. A., and Gallagher, W. M; (2010) 'Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis'. Pigment Cell & Melanoma Research, 23 (4):542-553. [Details]
Hoffmann, D., Adler, M., Vaidya, V., Rached, E., Mulrane, L., Gallagher, W. M., Callanan, J. J., Gautier, J. C., Matheis, K., Staedtler, F., Dieterle, F., Brandenburg, A., Sposny, A., Hewitt, P., Ellinger-Ziegelbauer, H., Bonventre, J. V., Dekant, W., and Mally, A.; (2010) 'Performance of novel kidney biomarkers in preclinical toxicity studies'. Toxicological sciences : an official journal of the Society of Toxicology, 116 (1):8-22. [Details]
Collins, B. C., Sposny, A., McCarthy, D., Brandenburg, A., Woodbury, R., Pennington, S. R., Gautier, J. C., Hewitt, P., and Gallagher, W. M; (2010) 'Use of SELDI MS to discover and identify potential biomarkers of toxicity in InnoMed PredTox: A multi-site, multi-compound study'. Proteomics, 10 (8):1592-1608. [Details]
Brennan, D. J., Brandstedt, J., Rexhepaj, E., Foley, M., Ponten, F., Uhlen, M., Gallagher, W. M., O'Connor, D. P., O'Herlihy, C., and Jirstrom, K; (2010) 'Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer'. BMC Cancer, 10 . [Details]
McSherry, EA,Mcgee, SF,Jirstrom, K,Doyle, EM,Brennan, DJ,Landberg, G,Dervan, PA,Hopkins, AM,Gallagher, WM; (2009) 'JAM-A expression positively correlates with poor prognosis in breast cancer patients'. International Journal of Cancer, 125 (NA):1343-1351. [DOI] [Details]
Strömberg, S., Agnarsdóttir, M., Magnusson, K., Rexhepaj, E., Bolander, A., Lundberg, E., Asplund, A., Ryan, D., Rafferty, M., Gallagher, W. M., Uhlen, M., Bergqvist, M., and Ponten, F; (2009) 'Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma'. Journal of Proteome Research, 8 (4):1639-1646. [Details]
Lanigan, F,McKiernan, E,Brennan, DJ,Hegarty, S,Millikan, RC,McBryan, J,Jirstrom, K,Landberg, G,Martin, F,Duffy, MJ,Gallagher, WM; (2009) 'Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer'. International Journal of Cancer, 124 (NA):2088-2097. [DOI] [Details]
Byrne, A. T., O'Connor, A. E., Hall, M., Murtagh, J., O'Neill, K., Curran, K. M., Mongrain, K., Rousseau, J. A., Lecomte, R., McGee, S., Callanan, J. J., O'Shea, D. F., and Gallagher, W. M.; (2009) 'Vascular targeted photodynamic therapy with BF2-chelated tetraaryl-azadipyromethene agents: A multi-modality molecular imaging approach to therapeutic assessment'. British Journal of Cancer, 101 (9):1565-1573. [Details]
Power, KA,McRedmond, JP,de Stefani, A,Gallagher, WM,Gaora, PO; (2009) 'High-Throughput Proteomics Detection of Novel Splice Isoforms in Human Platelets'. PLoS ONE, 4 (3). [DOI] [Details]
Gremel, G., Rafferty, M., Lau, T. Y. K., and Gallagher, W. M. ; (2009) 'Identification and functional validation of therapeutic targets for malignant melanoma'. Critical Reviews in Oncology Hematology, 72 :194-214. [Details]
O'Connor, A. E., Byrne, A. T., and Gallagher, W. M. ; (2009) 'Porphyrin and non-porphyrin photosensitizers in oncology: pre-clinical and clinical advances in photodynamic therapy'. Photochemistry and photobiology, 85 (5):1053-1074. [Details]
Patel, K. D., Duggan, S. P., Currid, C. A., Gallagher, W. M., McManus, R., Kelleher, D., Murphy, R. T., and Ryan, A. W. ; (2009) 'High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of interferon gamma and interleukin-10 post myocardial infarction'. Clinical Immunology, 133 (2):251-256. [Details]
Brennan, D. J., Hewitt, S. M., Rexhepaj, E., O¿Brien, S. L., McSherry, E., O¿Connor, D. P., Fagan, A., Culhane, A. C., Higgins, D. G., Jirstrom, K., Millikan, R. C., Landberg, G., Duffy, M. J., and Gallagher, W. M. ; (2008) 'Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer'. Clinical Cancer Research, 14 (9):2681-2689. [DOI] [Details]
Gallagher WM, Lau TY, O'Connor DP, Brennan DJ, Duffy MJ, Pennington SR, ; (2007) 'Breast cancer proteomics: clinical perspectives'. Expert Opinion on Biological Therapy, 2 (NA):209-219. [DOI] [Details]
Gallagher WM, Brennan DJ, Kelly C, Rexhepaj E, Dervan PA, Duffy MJ, ; (2007) 'Contribution of DNA and tissue microarray technology to the identification and validation of biomarkers and personalised medicine in breast cancer'. Cancer Genomics Proteomics, 3 (NA):121-134. [Details]
Mc Sherry, EA,Mc Goldrick, A,Kay, EW,Hopkins, AM,Gallagher, WM,Dervan, PA; (2007) 'Formalin-fixed paraffin-embedded clinical tissues show spurious copy number changes in array-CGH profiles'. Clinical Genetics, 72 (NA):441-447. [DOI] [Details]
Currid, CA,O'Connor, DP,Chang, BD,Gebus, C,Harris, N,Dawson, KA,Dunn, MJ,Pennington, SR,Roninson, IB,Gallagher, WM; (2006) 'Proteomic analysis of factors released from p21-overexpressing tumour cells'. Proteomics, 6 (NA):3739-3753. [DOI] [Details]
Dawson KA, Gallagher WM, Lynch I, Allen LT, Miller I, Penney SC, O'Connor DP, Pennington S, Keenan AK, ; (2006) 'Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies'. Biomaterials, 27 (35):5871-5882. [DOI] [Details]
Keenan AK, McGillicuddy FC, Lynch I, Rochev YA, Burke M, Dawson KA, Gallagher WM, ; (2006) 'Novel plum pudding gels as potential drug-eluting stent coatings: controlled release of fluvastatin'. Journal of Biomedical Materials Research Part A, 79 (4):923-933. [DOI] [Details]
McDonnell, SO,Hall, MJ,Allen, LT,Byrne, A,Gallagher, WM,O'Shea, DF; (2005) 'Supramolecular photonic therapeutic agents'. Journal of the American Chemical Society, 127 (NA):16360-16361. [DOI] [Details]
Gallagher, WM,Bergin, OE,Rafferty, M,Kelly, ZD,Nolan, IM,Fox, EJP,Culhane, AC,McArdle, L,Fraga, MF,Hughes, L,Currid, CA,O'Mahony, F,Byrne, A,Murphy, AA,Moss, C,McDonnell, S,Stallings, RL,Plumb, JA,Esteller, M,Brown, R,Dervan, PA,Easty, DJ; (2005) 'Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies'. Carcinogenesis, 26 (NA):1856-1867. [DOI] [Details]
Tacke, M,Cuffe, LP,Gallagher, WM,Lou, Y,Mendoza, O,Muller-Bunz, H,Rehmann, FJK,Sweeney, N; (2004) 'Methoxy-phenyl substituted ansa-titanocenes as potential anti-cancer drugs derived from fulvenes and titanium dichloride'. Journal of Inorganic Biochemistry, 98 (NA):1987-1994. [DOI] [Details]
Gorman, A,Killoran, J,O'Shea, C,Kenna, T,Gallagher, WM,O'Shea, DF; (2004) 'In vitro demonstration of the heavy-atom effect for photodynamic therapy'. Journal of the American Chemical Society, 126 (NA):10619-10631. [DOI] [Details]
Killoran, J,Allen, L,Gallagher, JF,Gallagher, WM,O'Shea, DF; (2002) 'Synthesis of BF2 chelates of tetraarylazadipyrromethenes and evidence for their photodynamic therapeutic behaviour'. Chemical Communications, -1 (17):1862-1863. [DOI] [Details]
Brennan, D. J., Ek, S., Doyle, E., Drew, T., Foley, M., Flannelly, G., O¿Connor, D. P., Gallagher, W. M., Kilpinen, S., Kallioniemi, O-P., Jirstrom, K., O¿Herlihy, C., and Borrebaeck, C. A. K. ; (2009) 'The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer'. European Journal of Cancer, 45 (8):1510-1517. [DOI] [Details]
Koenig J, Gallagher WM, Tweats D, ; (2009) 'Omic profiling for drug safety assessment: current trends and public-private partnerships'. Drug Discovery Today, 14 (7-8):337-342. [Details]
Gremel, G., Rafferty, M., Fitzgerald, K., Pizzato, S., Gallagher, W. M., ; (2008) 'Differential cell adhesion within an isogenic model of melanoma progression under shear flow conditions using a microfluidic cell-based assay'. Pigment Cell & Melanoma Research, 21 (2):285-285. [Details]
Brennan, D. J., Gallagher, W. M., ; (2008) 'Prognostic ability of a panel of immunohistochemistry markers - retailoring of an 'old solution''. Breast Cancer Research, 10 (102):1-3. [DOI] [Details]
O'Riordan A, Johnston O, McMorrow T, Wynne K, Maguire P, Hegarty JE, McCormick A, Watson AJ, Cagney G, Gallagher WM, Ryan MR; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (9):1338-1348. [Details]
Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M; (2008) 'A microRNA DNA methylation signature for human cancer metastasis'. PNAS, 105 (36):13556-13561. [Details]
Gallagher WM, Mulrane L, Rexhepaj E, Penney S, Callanan JJ, ; (2008) 'Automated image analysis in histopathology: a valuable tool in medical diagnostics'. EXPERT REV MOL DIAGN, 6 (NA):707-725. [DOI] [Details]
Gallagher WM, Duffy MJ, McGowan PM, ; (2008) 'Cancer invasion and metastasis: changing views'. The Journal of pathology, 3 (NA):283-293. [DOI] [Details]
Whelan LC, Power KA, McDowell DT, Kennedy PJ, Gallagher WM.; (2008) 'Applications of seldi technology in oncology'. Journal of cellular and molecular medicine, (NA). [DOI] [Details]
Rexhepaj, E., Brennan, D. J., Holloway, P., Kay, E. W., McCann, A. H., Landberg, G., Duffy, M. J., Jirstrom, K., and Gallagher, W. M. ; (2008) 'Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of estrogen and progesterone receptor levels in breast cancer'. Breast cancer research : BCR, 10 (5). [DOI] [Details]
Mulrane, L., Rexhepaj, E., Smart, V., Callanan, J. J., Orhan, D., Eldem, T., Mally, A., Schroeder, S., Meyer, K., Wendt, M., O'Shea, D., Gallagher, W. M., ; (2008) 'Creation of a digital slide and tissue microarray resource from a multi-institutional predictive toxicology study in the rat: An initial report from the PredTox group'. Experimental and Toxicologic Pathology, 60 (4-5):235-245. [Details]
Pennington SR, Collins BC, Clarke A, Kitteringham NR, Gallagher WM, ; (2007) 'Use of proteomics for the discovery of early markers of drug toxicity'. Expert Opinion on Drug Metabolism & Toxicology, 5 (NA):689-704. [DOI] [Details]
Lanigan, F., O'Connor, D., Martin, E., Gallagher, W. M., ; (2007) 'Common molecular links between mammary gland development and breast cancer'. Cellular and Molecular Life Sciences, 64 (24):3161-3184. [Details]
Duffy, M. J., O'Donovan, N., Brennan, D. J., Gallagher, W. M., and Ryan, B. M; (2007) 'Survivin: a promising tumor biomarker'. Cancer Letters, 249 (1):49-60. [Details]
Hughes, L., O' Brien, S., and Gallagher, W. M., and McDonnell, S. ; (2007) 'DNA microarray-based transcriptomic profiling of an isogenic cell culture model of breast tumour cell invasion'. Anticancer Research, 27 :1353-1360. [Details]
Rafferty, M., Faller, W. J., Moss, C., McCormick, J., Easty, D. J., and Gallagher, W. M. ; (2007) 'Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of melanoma progression-associated genes'. Anticancer Research, 27 :1301-1308. [Details]
Sallyann L O'brien , Ailís Fagan , Edward J P Fox , Robert C Millikan , Aedín C Culhane , Donal J Brennan , Amanda H McCann , Shauna Hegarty , Siobhan Moyna , Michael J Duffy , Desmond G Higgins , Karin Jirström , Göran Landberg , William M Gallagher ; (2007) 'CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer'. International Journal of Cancer, 120 (7):1426-1435. [Details]
McGee, S. F., O?Connor, D. P., and Gallagher, W. M.; (2006) 'Functional interrogation of breast cancer: from models to drugs'. Drug Discovery Today, 1 (6):569-584. [Details]
Smith, FM; Gallagher, WM; Fox, E; Stephens, RB; Rexhepaj, E; Petricoin, EF; Liotta, L; Kennedy, MJ; Reynolds, JV; ; (2007) 'Combination of SELDI-TOF-MS and data mining provides early-stage response prediction for rectal tumors undergoing multimodal neoadjuvant therapy'. Annals of Surgery, 245 (2):259-266. [Details]
Allen, LT; Tosetto, M; Miller, IS; O'Connor, DP; Penney, SC; Lynch, I; Keenan, AK; Pennington, SR; Dawson, KA; Gallagher, WM; ; (2006) 'Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction'. Biomaterials, 27 (16):3096-3108. [Details]
Sweeney, N; Gallagher, WM; Muller-Bunz, H; Pampillon, C; Strohfeldt, K; Tacke, M; ; (2006) 'Heteroaryl substituted titanocenes as potential anti-cancer drugs'. Journal of Inorganic Biochemistry, 100 (9):1479-1486. [Details]
Lynch, I; Miller, I; Gallagher, WM; Dawson, KA; ; (2006) 'Novel method to prepare morphologically rich polymeric surfaces for biomedical applications via phase separation and arrest of microgel particles'. Journal of Physical Chemistry B, 110 (30):14581-14589. [Details]
McGillicuddy, FC; O'Toole, D; Hickey, JA; Gallagher, WM; Dawson, KA; Keenan, AK; ; (2006) 'TGF-beta 1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells'. Vascular Pharmacology, 44 (6):469-475. [Details]
Easty, D; Gallagher, W; Bennett, DC; ; (2006) 'Protein tyrosine phosphatases, new targets for cancer therapy'. Current Cancer Drug Targets, 6 (6):519-532. [Details]
Brennan, DJ; Jirstrom, K; Kronblad, A; Millikan, RC; Landberg, G; Duffy, MJ; Ryden, L; Gallagher, WM; O'Brien, SL; ; (2006) 'CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance'. Clinical Cancer Research, 12 (21):6421-6431. [Details]
Duggan, SP; Gallagher, WM; Fox, EJP; Abdel-Latif, MM; Reynolds, JV; Kelleher, D; ; (2006) 'Low pH induces co-ordinate regulation of gene expression in oesophageal cells'. Carcinogenesis, 27 (2):319-327. [Details]
Conway, CM; O'Shea, D; O'Brien, S; Lawler, DK; Dodrill, GD; O'Grady, A; Barrett, H; Gulmann, C; O'Driscoll, L; Gallagher, WM; Kay, EW; O'Shea, DG; ; (2006) 'The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line'. BMC Bioinformatics, 7 (NA). [Details]
Kavanagh, CA; Gorelova, TA; Selezneva, II; Rochev, YA; Dawson, KA; Gallagher, WM; Gorelov, AV; Keenan, AK; ; (2005) 'Poly(N-isopropy acrylamide) copolymer films as vehicles for the sustained delivery of proteins to vascular endothelial cells'. Journal of Biomedical Materials Research Part A, 72A (1):25-35. [Details]
Rehmann, FJK; Cuffe, LP; Mendoza, O; Rai, DK; Sweeney, N; Strohfeldt, K; Gallagher, WM; Tacke, M; ; (2005) 'Heteroaryl substituted ansa-titanocene anti-cancer drugs derived from fulvenes and titanium dichloride'. Applied Organometallic Chemistry, 19 (3):293-300. [Details]
Gallagher, W. M., Currid, C. A., & Whelan, L. C.; (2005) 'Fibulins and cancer: friend or foe?'. Trends in Molecular Medicine, 11 (7):336-340. [Details]
Gallagher, W.M., Allen, L.T., O'Shea, C., Kenna, T., Hall, M., Gorman, A., Killoran, J., and O'Shea, D.F.; (2005) 'A potent non-porphyrin class of photodynamic therapeutic agent: cellular localisation, cytotoxic potential and influence of hypoxia'. BRITISH JOURNAL OF CANCER, 92 (9):1702-1710. [Details]
Brennan, DJ; O'Brien, SL; Fagan, A; Culhane, AC; Higgins, DG; Duffy, MJ; Gallagher, WM; ; (2005) 'Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response'. Expert Opinion on Biological Therapy, 5 (8):1069-1083. [Details]
Lynch, I; Blute, IA; Zhmud, B; MacArtain, P; Tosetto, M; Allen, LT; Byrne, HJ; Farrell, GF; Keenan, AK; Gallagher, WM; Dawson, KA; ; (2005) 'Correlation of the adhesive properties of cells to N-isopropylacrylamide/N-tert-butylacrylamide copolymer surfaces with changes in surface structure using contact angle measurements, molecular simulations, and Raman spectroscopy'. Chemistry of Materials, 17 (15):3889-3898. [Details]
Duffy, M.J., Kelly, Z.D., Culhane, A.C., O'Brien, S., & Gallagher, W.M.; (2005) 'DNA microarray-based gene expression profiling in cancer: aiding cancer diagnosis, assessing prognosis and predicting response to therapy'. Current Pharmacogenomics, 3 :289-304. [Details]
Rehmann, FJK; Rous, AJ; Mendoza, O; Sweeney, NJ; Strohfeldt, K; Gallagher, WM; Tacke, M; ; (2005) 'A trimethoxyphenyl substituted ansa-titanocene: A possible anti-cancer drug'. Polyhedron, 24 (11):1250-1255. [Details]
Kavanagh, CA; Rochev, YA; Gallagher, WA; Dawson, KA; Keenan, AK; ; (2004) 'Local drug delivery in restenosis injury: thermoresponsive co-polymers as potential drug delivery systems'. Pharmacology and Therapeutics, 102 (1):1-15. [Details]
Tacke, M; Allen, LT; Cuffe, L; Gallagher, WM; Ying, L; Mendoza, O; Muller-Bunz, H; Rehmann, FJK; Sweeney, N; ; (2004) 'Novel titanocene anti-cancer drugs derived from fulvenes and titanium dichloride'. Journal of Organometallic Chemistry, 689 (13):2242-2249. [Details]
McArdle, L; McDermott, M; Purcell, R; Grehan, D; O'Meara, A; Breatnach, F; Catchpoole, D; Culhane, AC; Jeffery, I; Gallagher, WM; Stallings, RL; ; (2004) 'Oligonucleotide microarray analysis of gene expression in neuroblastoma displaying loss of chromosome 11q'. Carcinogenesis, 25 (9):1599-1609. [Details]
Doorty, KB; Golubeva, TA; Gorelov, AV; Rochev, YA; Allen, LT; Dawson, KA; Gallagher, WM; Keenan, AK; ; (2003) 'Poly(N-isopropylacrylamide) co-polymer films as potential vehicles for delivery of an antimitotic agent to vascular smooth muscle cells'. Cardiovascular Pathology, 12 (2):105-110. [Details]
Allen, LT; Fox, EJP; Blute, I; Kelly, ZD; Rochev, Y; Keenan, AK; Dawson, KA; Gallagher, WM; ; (2003) 'Interaction of soft condensed materials with living cells: Phenotype/transcriptome correlations for the hydrophobic effect'. Proceedings of the National Academy of Sciences of the United States of America, 100 (11):6331-6336. [Details]
Argraves, WS; Greene, LM; Cooley, MA; Gallagher, WM; ; (2003) 'Fibulins: physiological and disease perspectives'. Embo Reports, 4 (12):1127-1131. [Details]
Wilson, SJ; Gorelov, AV; Rochev, YA; McGillicuddy, F; Dawson, KA; Gallagher, WM; Keenan, AK; ; (2003) 'Extended delivery of the antimitotic agent colchicine from thermoresponsive N-isopropylacrylamide-based copolymer films to human vascular smooth muscle cells'. Journal of Biomedical Materials Research Part A, 67A (2):667-673. [Details]
Greene, L. M., Twal, W. O., McDermott, E. W., Hill, A. D., O Higgins, N. J., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M.; (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. British Journal of Cancer, 88 (6):871-878. [Details]
Wilson, S. W., Gorelov, A., Rochev, Y., McGillicuddy, F., Dawson, K. A., Gallagher, W. M., and Keenan, A. K.; (2003) 'Extended delivery of the anti-mitotic agent colchicines from thermoresponsive N-isopropylarcylamide-based co-polymer films to human vascular smooth muscle cells'. Journal of Biomedical Materials Research, 67A (2):667-673. [Details]
Gallagher, W. M., Greene, L. M., Allen, L. T., Strachan, S. M., Rochev, Y., Dawson, K. A., Ryan, M. P., and Conseiller, E.; (2001) 'Contemporary strategies for cancer therapy: the p53 gene as a paradigm. [Not indexed in JCR; ISBN 92-894-1575-4: Also available via http://www.mariecurie.org/annals/]'. The Annals of the Marie Curie Fellowships, 1 :106-111. [Details]
Rochev, Y., Golubeva, T., Gorelov, A., Allen, L., Gallagher, W. M., Selezneva, I., Gavrilyuk, B., and Dawson, K.; (2001) 'Surface modification for controlled cell growth on co-polymers of N-isopropylacrylamide'. Progress in Colloid and Polymer Science, 118 :153-156. [Details]
Doorty, KB; Golubeva, T; Gorelov, A; Rochev, Y; Dawson, K; Gallagher, WM; Keenan, AK; ; (2001) 'Investigation of co-polymer films as drug delivery systems for prevention of vascular smooth muscle cell proliferation'. British Journal of Pharmacology, 134 (NA). [Details]
Gallagher, W. M., Greene, L. M., Ryan, M. P., Sierra, V., Berger, A., Laurent-Puig, P., and Conseiller, E.; (2001) 'Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissue'. FEBS Letters, 489 (1):59-66. [Details]
Gallagher, W. M., and Brown, R.; (1999) 'p53-oriented cancer therapies: current progress'. Annals of Oncology, 10 :139-150. [Details]
Gallagher, W. M., Argentini, M., Sierra, V., Bracco, L., Debussche, L., and Conseiller, E.; (1999) 'MBP1: a novel mutant p53-specific protein partner with oncogenic properties'. Oncogene, 18 :3608-3616. [Details]
Brown, R., Hirst, G. L., Gallagher, W. M., McIlwrath, A. J., Margison, G. P., van der Zee, A. G. J., and Anthoney, D. A.; (1997) 'hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents'. Oncogene, 15 :42-52. [Details]
Gallagher, W. M., Cairney, M., Schott, B., Roninson, I. B., and Brown, R.; (1997) 'Identification of p53 genetic suppressor elements which confer resistance to cisplatin'. Oncogene, 14 :185-193. [Details]
Anthoney, D. A., McIlwrath, A. J., Gallagher, W. M., Edlin, A. R., and Brown, R.; (1996) 'Microsatellite instability, apoptosis and loss of p53 function in drug-resistant tumor cells'. Cancer Research, 56 :1374-1381. [Details]
Gallagher, W. M., and Grant, G. H.; (1996) 'Structural basis of p21H-ras molecular switch inhibition by a neutralizing antibody'. Journal of Molecular Graphics, 14 (1):42-50. [Details]
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Other Journals

Power, KA, Collins, BC, Whelan, LC and Gallagher, WM. ; (2007) 'Proteomes and drug development - the fast track' European Biopharmaceutical Review Winter ed :90-95. [Details]

Kavanagh, C.A., Gorelova, T.A., Selezneva, II., Rochev, Y.A., Dawson, K.A., Gallagher, W.M., Gorelov, A.V., Keenan, A.K.; (2006) 'Poly(N-isopropylacrylamide) copolymer films as vehicles for the sustained delivery of proteins to vascular endothelial cells' J Biomed Mater Res A 72 (1) :25-35. [Details]

Kavanagh, C.A., Rochev, Y., Gorelov, A., Gallagher, W.M., & Keenan, A.K.; (2005) 'Thermoresponsive p(N-isopropylacrylamide)-based co-polymers as protein delivery systems and substrates for re-endothelialisation' Proceedings of the British Pharmacological Society 2 (2) . [Details]

Nolan, IM; Fox, EJ; Moss, C; Leahy, DT; Geraghty, R; Mulcahy, HE; Hyland, JP; Fennelly, D; Sheahan, K; O'Donoghue, D; Argraves, WS; Gallagher, WM; ; (2004) 'Fibulin-1 and-4 mRNA expression levels in human colorectal cancer' British Journal of Cancer 91 (NA) :70-70. [Details]

Conference Publications

Malone, C., McGee, S., Hughes, L., Gallagher, W.M., and S. McDonnell; (2008) Effect of PLAC8 knockdown in breast cancer cell line growth 4th All Ireland Cancer Conference, Dublin, December, 2008 [Details]

Byrne AT, OConnor A, Hall M, ONeill K, Curran KM, Mongrain K, Lecomte R, McGee S, OS- hea D, Gallagher W. ; (2008) Vascular targeted photodynamic therapy with Azadipyromethene (ADPM) therapeutics: A new family of imageable photosensitizers American Association for Cancer Research [Details]

Byrne A, O¿Connor A, Hall MJ, Murtagh J, O¿Neill K, Curran KM, Mongrain K, Lecomte R, McGee S, O¿Shea DF, Gallagher WM.; (2008) Vascular Targeted Photodynamic Therapy with ADPM Agents Irish Association for Cancer Research [Details]

Malone, C., McGee, S., Hughes, L., Gallagher, W.M. and S McDonnell (; (2008) Study of the Functional Effects of Lentiviral-Mediated RNAi Knockdown of Novel Gene PLAC8 in Breast Cancer Progression Irish Association for Cancer Research, Annual Meeting [Details]

Malone, C., McGee, S., Hughes, L., Gallagher, W.M. and S McDonnel; (2007) Lentiviral-Mediated RNAi Knockdown of Novel Breast Cancer Associated Gene PLAC8 AACR Special Conference in Cancer Research [Details]

Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
Dowling, D., Miller, I., Duggan, P., Byrne, G., Gallagher, W.; (2006) Influence of the surface properties of plasma modified polystyrene on cell morphology and spreading SVC 49th Annual Technical Conference Proceedings [Details]
O' Riordan A, McMorrow T, Johnston O, Gallagher W, Maguire P, Cagney G, Hegarty J, McCormick A, Watson AJ and Ryan MP.; (2006) Using SELDI-TOF-MS Apo A1 is a serum biomarker of chronic kidney disease, post orthotopic liver transplantation American Society of Nephrology [Details]
Johnston O, Conlon PJ, McMorrow T, O'Riordan A, Gallagher W, Maguire P, Wynne K, Cagney G, and Ryan MP.; (2006) Urinary B2-microglobulin as a novel potential biomarker for chronic allograft nephropathy American Society of Nephrology [Details]
Brennan, D.J., Hewitt, S.M., Fox, E.J.P., O'Brien, S., Jirstrom, K., Duffy, M.J., Landberg, G., McCann, A., & Gallagher, W.M.; (2006) Automated quantitative analysis of immunohistochemistry linked to clinical outcome * Dublin, Ireland, [Details]
Malone, C., Hughes, L., Gallagher, W.M. & McDonnell, S.; (2006) Investigation of potential markers of breast cancer invasion EMBO Molecular Medican Conference. Common Molecular Mechanisms of Mammary Gland Developmet and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
Hughes, L., Malone, C., O'Brien, S., Gallagher, W.M. & McDonnell, S.; (2006) Expression of candidate invasion-specific genes, PLAC8, CTAG1B, Lumican and Decorin in human cancer cell lines Irish Association for Cancer Research Annual Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
O'Connor, D.P., O'Donoghue, N., Currid, C.A., Chang, B.-D., Roninson, I.B., Dunn, M.J., Pennington, S.R., & Gallagher, W.M.; (2006) p21, p16 and p27, more than just cell cycle inhibitors Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
Collins, B.C., O'Connor, D.P., Currid, C.A., Chang, B., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B. & Gallagher, W.M.; (2006) Proteomic analysis of cyclin-dependant kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-Gel electrophoresis/peptide mass fingerprinting 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
O'Connor, D.P., Collins, B.C., Currid, C., Chang, B.-D., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2006) Proteomic analysis of p21-regulated protein expression Gordon Research Conference: Cancer Models and Mechanisms Rhode Island, USA, , 01-AUG-06 - 04-AUG-06 [Details]
Malone, C., Hughes, L., Gallagher, W.M. & McDonnell, S.; (2006) Identification and expression analysis of candidate markers of breast cancer invaison 19th European Association for Cancer Research Budapest, Hungary, , 01-JUL-06 - 04-JUL-06 [Details]
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M. Dervan, P.A.; (2006) Array CGH-based analysis of ductal breast cancer variants: comparing in situ and invasive carcinomas European Association for Cancer Research [Details]
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M. Dervan, P.A.; (2006) Investigation of Genetic Alterations in Ductal Breast Cancer Subtypes Using Array-CGH Mater 9th International Breast Cancer Meeting [Details]
O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P.; (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P.; (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McSherry, E.A., Gallagher, W.M., Dervan, P.A. Hopkins, A.M.; (2005) Modelling Breast Cancer Progression Via Integrated 2- and 3- Dimensional Cell Culture Systems American Association for Cancer Research Special Conference in Cancer Research - Advances in Breast Cancer Research: Genetics, Biology and Clinical Applications , 21-SEP-05 - 25-SEP-05 [Details]
Hayley, D., McKeen, H. D., Brennan, D. J., Hegarty, S., Lanigan, F., Jirstrom, K., Byrne, C., Yakkundi, A., McCarthy, H. O., Gallagher, W. M., and Robson, T. ; (2011) The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL . In: Konstantin Panov (Queen's University Belfast, U.K.) and Paul Thompson (University of Ulster, Coleraine, U.K.) eds. Biochemical Society Irish Area Section Meeting - Signalling and Disease , pp.663-668 [Details]
Maher, S.G., McDowell, D.T., Murphy, S.A., Collins, B.C., Muldoon, C., Gallagher, W.M., Reynolds, J.V. ; (2011) Pre-treatment complement system serum protein levels predict response to neoadjuvant chemoradiation for oesophageal cancer The Annual Meeting of the Society of Academic and Research Surgery , pp.1-5 [Details]
Dolan, R.T., Penny, S., Kelly, C.M., (Kelly, Brennan, D.J., Rexhepaj, E., Jirstrom, K., Ponten, F., Uhlen, M., Gallagher, W.M., Kell, M.R; (2011) Development of immunohistochemical surrogates for prediction of breast cancer patient outcome via high-throughput antibody generation and validation using tissue microarray technology The Annual Meeting of the Society of Academic and Research Surgery , pp.1-5 [Details]
Dahlman, A.K., Rexhepaj, E; Brennan, D.J., Gallagher, W.M., Gaber, A., Lindgren, A., Jirstrom, K., Bjartell, A.; (2011) Automated image analysis confirms the predictive significance of MSMB in prostate cancer 26 Annual Congress of the European Association of Urology , pp.I-XIV [Details]
Maher, S.G., McDowell, D.T., Murphy, S.A., Collins, B.C., Pidgeon, G.P.; Gallagher, W.M., Reynolds, J.V. ; (2010) Complement C4A anaphylatoxin as a putative biomarker of response to neoadjuvant chemoradiation for oesophageal cancer 44th Annual Scientific Meeting of the Vascular Society of Great Britain and Ireland , pp.1-18 [Details]
Foley, R., Gallagher, W. M., Callanan, S., and Cunningham, P. ; (2010) A Machine Learning System for Identifying Hypertrophy in Histopathology Images 20th Irish Conference on Artificial Intelligence and Cognitive Science [Details]
McGee, S.F., O' Connor, D.P., Mc Donnell, S., Duffy, M.J., Gallagher, W.M; (2009) A functional genomics screen identifies serpinB2 as a key mediator of breast cancer progression The Metastasis Research Society-American Association for Cancer Research Conference on Metastasis [Details]
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M. Dervan, P.A.; (2006) Array CGH-based analysis of ductal breast cancer variants: comparing in situ and invasive carcinomas European Association for Cancer Research , 01-JUL-06 - 04-JUL-06 [Details]
Byrne, A.T., Miller, I., Hall, M., Holmes, L., O'Shea, D.F., Wilde, C., Gallagher, W.M.; (2006) New cell-based assay for comparisons of caspase 3/7 activity in normal versus tumor cell populations 97th Annual Meeting of the American Association of Cancer Research Washington DC, USA, , 01-APR-06 - 05-APR-06 [Details]
Hegarty, S., Murray, E., McAllister, K., Ryan, D., Rafferty, M., Gallagher, W.M., Dervan, P.A.; (2006) Malignant melanoma: using tissue microarrays to understand a killer Association of Clinical Pathologists International Scientific Meeting Praque, [Details]
McSherry, E. A., McGoldrick, A., Hopkins, A. M., Gallagher, W. M., Dervan, P. A.; (2006) Array CGH-based analysis of genetic alterations in ductal breast cancer subtypes EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 12-JUL-06 - 14-JUL-06 [Details]
Ryan, D., Rafferty, M., McSherry, E., McGoldrick, A., Dervan, P. A., Gallagher, W. M.; (2006) Array-based CGH analysis of a cohort of melanoma cell lines Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-APR-06 - 04-APR-06 [Details]
Ryan, D., Rafferty, M., McSherry, E., McGoldrick, A., Dervan, P.A., Gallagher, W.M.; (2006) Comparative genomic hybridisation study on a cohort of melanoma cell lines Centenary Meeting of the Pathological Society of Manchester University Of Manchester, , 04-JUL-06 - 07-JUL-06 [Details]
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., Dervan, P.A.; (2006) Genetic determinants of progression of ductal carcinoma in situ to invasive breast cancer Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
Lanigan, F., McBryan, J., Brennan, D., Duffy, M.J., Martin, F. & Gallagher, W.M.; (2006) Identification of common pathways involved in pubertal mammary gland development and breast cancer EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
Hegarty, S., Murray, E., McAllister, K., Ryan, D., Rafferty, M., Gallagher, W.M., Dervan, P.A.; (2006) Malignant melanoma: using tissue microarrays to understand a killer Pathological Society Centenary Meeting Manchester, UK, [Details]
Johnston, O., O'Riordan, A., McMorrow, T., Gallagher, W., Walshe, J.J., Conlon, P.J. and Ryan, M.P.; (2005) Optimizing proteomic profile analysis in chronic renal transplant recipients American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
McGee, S., McArdle, E., O'Brien, S., Martin, F., O'Connor, D., & Gallagher, W.M.; (2005) Optimisation of a lentiviral delivery system for functional interrogation of breast cancer-associated genes Cold Spring Harbor Laboratory Conference: RNA Interference New York, USA, , 28-SEP-05 - 02-OCT-05 [Details]
McGee, S., McArdle, E., O'Brien, S., Martin, F., O'Connor, D., & Gallagher, W.; (2005) Optimisation of a lentiviral delivery system for functional interrogation of breast cancer-associated genes 3rd Annual National Symposium of the Irish Research Council for Science, Engineering and Technology (IRCSET) Dublin, Ireland, , 03-NOV-05 [Details]
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., Dervan, P.A; (2005) Genetic determinants of progression of ductal carcinoma in situ to invasive breast cancer 3rd Annual National Symposium of the Irish Research Council for Science, Engineering and Technology (IRCSET) Dublin, Ireland, , 03-NOV-05 [Details]
Currid, C., O'Connor, D.P., Gebus, C., Chang, B.-D., Harris, N., Dawson, K., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2005) Proteomic analysis of factors released from p21-overexpressing tumour cells HUPO 4th Annual World Congress Berlin, Germany, , 28-AUG-05 - 01-SEP-05 [Details]
O' Riordan, A., McMorrow, T., Johnston, O., Gallagher, W., Watson, A.J. and Ryan, M.P.; (2005) Proteome analysis and biomarker discovery in calcineurin inhibitor nephrotoxicity post liver transplantation American Society of Nephrology Philadelphia, USA, , 09-NOV-05 - 13-NOV-05 [Details]
Cummins, E., Gallagher, W.M., O'Brien, E., Stanton, A., Cagney, G., & Cahill, D.J.,; (2005) Metabolic syndrome biomarker discovery by surface enhanced laser desorption/ionisation time-of-flight mass spectrometry HUPO 4th Annual World Congress Berlin, Germany, , 28-AUG-05 - 01-SEP-05 [Details]
Hall, M; Gallagher, WM; O'Shea, DF; ; (2005) ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY A potent non-porphyrin class of photodynamic therapeutic agent , pp.2698-2698 [Details]
Hughes, L., Malone, C., O'Brien, S., Gallagher, W.M. & McDonnell, S.; (2005) Development, characterisation and gene expression profiling of a novel more invasive variant established from the human breast cancer cell line Hs578T Development, characterisation and gene expression profiling of a novel more invasive variant established from the human breast cancer cell line Hs578T , pp.88-89 [Details]
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M. Dervan, P.A.; (2006) Investigation of Genetic Alterations in Ductal Breast Cancer Subtypes Using Array-CGH Mater 9th International Breast Cancer Meeting [Details]
McSherry, E.A., Gallagher, W.M., Dervan, P.A. Hopkins, A.M.; (2006) Modelling Breast Cancer Progression Via Integrated 2- and 3- Dimensional Cell Culture Systems American Association for Cancer Research Special Conference in Cancer Research - Advances in Breast Cancer Research: Genetics, Biology and Clinical Applications [Details]
Brennan, D.J., Hewitt, S.M., Fox, E.J.P., O'Brien, S., Jirstrom, K., Duffy, M.J., Landberg, G., McCann, A. & Gallagher, W.M.; (2006) Automated quantitative analysis of immunohistochemistry linked to clinical outcome Automated quantitative analysis of immunohistochemistry linked to clinical outcome Dublin, Ireland, [Details]
Gallagher, W.M.; (2006) Biomarker discovery via the SELDI platform: case studies in the cancer arena [NOTE: Keynote speaker] The Biomarker Discovery Event: Leveraging multiplex experimental technologies for drug development Basel, Switzerland, , 10-FEB-06 [Details]
Brennan, D.J., Kronblad, A., Jirstrom, K., Landberg, G., Duffy, M.J., Gallagher, W.M., & O'Brien, S.; (2006) Carbonic anhydrase IX is a new independent prognostic marker in pre-menopausal breast cancer patients with 1 to 3 positive lymph nodes 97th Annual Meeting of the American Association for Cancer Research Washington DC, USA, , 01-APR-06 - 05-APR-06 [Details]
Brennan, D.J., Kronblad, A., Jirstrom, K., Landberg, G., Duffy, M.J., Gallagher, W.M., & O'Brien, S.; (2006) Carbonic anhydrase IX is a new independent prognostic marker in pre-menopausal breast cancer patients with 1 to 3 positive lymph nodes Sylvester O'Halloran Surgical Scientific Meeting Ireland, , 03-MAR-06 [Details]
McGee, S., O'Connor, D., Roninson, I., Duffy, M., & Gallagher, W.M.; (2006) Construction of a lentiviral RNAi library for the functional analysis of genes associated with breast cancer metastasis EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
McSherry, E.A., McGoldrick, A., Hopkins, A.M., Gallagher, W.M., & Dervan, P.A.; (2006) Investigation of genetic alterations in ductal breast cancer subtypes using array-CGH Mater 9th International Breast Cancer Meeting Dublin, Ireland, , 07-APR-06 - 08-APR-06 [Details]
Faller, W., Rafferty, M., Fraga, M., Esteller, M., & Gallagher, W.; (2006) Methylation profiling of genes associated with melanoma progression 97th Annual Meeting of the American Association for Cancer Research Washington DC, USA, , 01-APR-06 - 05-APR-06 [Details]
Faller, W., Rafferty, M., Fraga, M., Esteller, M., & Gallagher, W.; (2006) Methylation profiling of genes associated with melanoma progression Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
Byrne, A.T., Miller, I., Hall, M., Holmes, L., O'Shea, D.F., Wilde, C., & Gallagher, W.M.; (2006) New cell-based assay for comparisons of caspase 3/7 activity in normal versus tumor cell populations 97th Annual Meeting of the American Association of Cancer Research Washington DC, USA, , 01-APR-06 - 05-APR-06 [Details]
O'Connor, D.P., O'Donoghue, N., Currid, C.A., Chang, B.-D., Roninson, I.B., Dunn, M.J., Pennington, S.R., & Gallagher, W.M.; (2006) p21, p16 and p27, more than just cell cycle inhibitors Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting Galway, Ireland, , 03-MAR-06 - 04-MAR-06 [Details]
Whelan, L.C., Murphy, A., Currid, C.A., O'Connor, D., & Gallagher, W.M.; (2006) ProteinChip facility at the Conway Institute: applications of SELDI-MS technology in biomedical research BioTekNet 2006 Meeting Dublin, Ireland, [Details]
Collins, B.C., O'Connor, D.P., Currid, C.A., Chang, B., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B. & Gallagher, W.M.; (2006) Proteomic analysis of cyclin-dependant kinase inhibitor (CDKI)-regulated protein expression in tumour cells via SELDI-TOF-MS and 2D-Gel electrophoresis/peptide mass fingerprinting 3rd Joint British Society for Proteomics Research/European Bioinformatics Research meeting Hinxton, Cambridge, UK, , 12-JUL-06 - 14-JUL-06 [Details]
Lau, T.Y., O'Connor, D.P., Hughes, L., McDonnell, S., Duffy, M.J., Martin, F., Pennington, S.R., & Gallagher, W.M.; (2006) Proteomic analysis of models of breast cancer progression EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression Dublin, Ireland, , 06-JUN-06 - 08-JUN-06 [Details]
O'Connor, D.P., Collins, B.C., Currid, C., Chang, B.-D., O'Donoghue, N., Pedersen, K., Dunn, M.J., Pennington, S.R., Roninson, I.B., & Gallagher, W.M.; (2006) Proteomic analysis of p21-regulated protein expression Gordon Research Conference: Cancer Models and Mechanisms Rhode Island, USA, , 01-AUG-06 - 04-AUG-06 [Details]
Faller, W., Rafferty, M., Fraga, M., Esteller, M., & Gallagher, W.; (2005) Methylation profiling of markers for melanoma progression 3rd Annual National Symposium of the Irish Research Council for Science, Engineering and Technology (IRCSET) Dublin, Ireland, , 03-NOV-05 [Details]
McSherry, E.A., Rafferty, M., Gallagher, W.M., Dervan, P.A. & Hopkins, A.M.; (2005) Modelling breast cancer progression via integrated 2- and 3-dimensional cell culture systems AACR Special Conference in Cancer Research ' Advances in Breast Cancer Research: Genetics, Biology and Clinical Applications , 21-SEP-05 - 25-SEP-05 [Details]
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Abstract

Kavanagh, C. A., Rochev, Y., Gorelov, A. V., Gallagher, W. M., and Keenan, A. K.; (2003) Surface expression of ICAM-1 on human endothelial cells grown on potential intra-vascular stent coatings. Abstract [Details]

Twal, W. O., Barth, J. L., Cooley, M. A., Chintalapudi, M. R., Gittinger, C. K., Kelly, Z. D. Greene, L. M., Gallagher, W, M., and Argraves, W. S.; (2003) Functional diversity in fibulin-1 by alternative splicing. Abstract [Details]

Lecka-Czernik, B., Greene, L. M., Sheahan, K., O Donoghue, D. P., and Gallagher, W. M.; (2002) S2-6, a novel marker for cancer detection and candidate tumor suppressor gene. Abstract [Details]

Kelly, Z. D., Barth, J. L., Fox, E. J. P., Greene, L. M., Knaak, C., Argraves, W. S., and Gallagher, W. M.; (2002) Gene expression profile analysis of tumor-derived cell lines overexpressing the candidate tumor suppressor gene, fibulin-1. Abstract [Details]

Greene, L. M., Twal, W. O., Foley, D. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M.; (2002) Dysregulated expression and proteolysis of fibulin-1 in human breast tumors. Abstract [Details]

Kelly, Z. D., Barth, J. L., Fox, E. J. P., Greene, L. M., Knaak, C., Murphy, A. A., Argraves, W. S., and Gallagher, W. M.; (2002) Gene expression profile analysis of tumor-derived cell lines overexpressing the candidate tumor suppressor gene, fibulin-1. Abstract [Details]
Greene, L. M., Twal, W. O., McDermott, E., O Higgins, N., Duffy, M. J., Argraves, W. S., and Gallagher, W. M.; (2002) Proteolysis of human fibulin-1 in breast carcinomas and in vitro. Abstract [Details]
Bergin, O. E., Gallagher, W. M., Kelly, Z. D., Fox, E. J. P., Currid, C. A., Dervan, P. A., and Easty, D. J.; (2002) Identification of candidate markers for melanoma progression. Abstract [Details]
Gallagher, W. M.; (2002) Careers in the life sciences. Abstract [Details]
Doorty, K. B., Golubeva, T., Gorelov, A., Rochev, Y., Dawson, K., Gallagher, W. M., and Keenan, A. K.; (2001) Investigation of co-polymer films as drug delivery systems for prevention of vascular smooth muscle cell proliferation. Abstract [Details]
Greene, L. M., Twal, W. O., Maguire, T., McCann, A., Dervan, P., Duffy, M. J., Argraves, W. S., and Gallagher, W. M.; (2001) Proteolytic processing of fibulin-1 in human breast tumors is linked with estrogen receptor status. Abstract [Details]
Rochev, Yu., Golubeva, T., Selezneva, I., Allen, L., Gavrilyuk, B., Gorelov, A., Gallagher, W., and Dawson, K.; (2000) Cell behaviour on thermoresponsive surfaces. Abstract [Details]
Gallagher, W. M.; (2000) The impact of the human genome project on science and society. Abstract [Details]
Gorelov, A., Golubeva, T., Rochev, Yu., Dawson, K., Gallagher, W., and Selezneva, I.; (2000) Surface modification for controlled cell growth on co-polymers of N-isopropylacrylamide. Abstract [Details]
Hobson, A., and Gallagher, W.; (2000) Irish group meets national contact point. Abstract [Details]
Gallagher, W. M., Greene, L. M., Strachan, S. M., Ryan, M. P., Sierra, V., Debussche, L., and Conseiller, E.; (2000) cDNA isolation, chromosomal localisation, and biochemical characterisation of the candidate human oncogene, fibulin-4. Abstract [Details]
Gallagher, W. M., Argentini, M., Sierra, V., Bracco, L., Debussche, L., and Conseiller, E.; (1999) MBP1, a new member of the fibulin gene family with both mutant p53-dependent and -independent oncogenic properties. Abstract [Details]
Brown, R., Hirst, G., McIlwrath, A. J., Gallagher, W. M., van der Zee, A., and Anthoney, A.; (1997) Loss of hMLH1 expression and cisplatin resistance in ovarian tumor cells. Abstract [Details]
Brown, R., McIlwrath, A., Vasey, P., Gallagher, W. and Anthoney, A.; (1996) Reduced p53-mediated apoptosis in cisplatin resistant ovarian cell lines. Abstract [Details]
McIlwrath, A., Gallagher, W., Anthoney, A., and Brown, R.; (1996) Apoptosis and mechanisms of cisplatin and ionising radiation resistance in ovarian carcinoma cell lines. Abstract [Details]
Gallagher, W., Gudkov, A. V., Roninson, I. B., and Brown, R.; (1996) Genetic suppressor elements from TP53 cDNA inducing cisplatin resistance in a human ovarian adenocarcinoma line. Abstract [Details]
Gallagher, W., McIlwrath, A., Edlin, A., Vasey, P., and Brown, R.; (1995) P53 mediated cell cycle arrests and apoptosis induced by the anti-cancer drug cis-diamminedichloroplatinum (II). Abstract [Details]
Gallagher, W., Edlin, A., and Brown, R.; (1995) Analysis of the p53-mediated DNA-damage response pathway in a cisplatin-resistant ovarian carcinoma line. Abstract [Details]
Brown, R., Edlin, A., McIlwrath, A., Vasey, P., Gallagher, W., Jenkins, S., and Kaye, S. B.; (1995) Dependence on wild-type p53 function for sensitivity of human ovarian tumour lines to DNA-damaging agents. Abstract [Details]
Chin, D., Duffy, M. J., Willcocks, T. C., Gallagher, W., O Higgins, N., and Parfrey, N.; (1994) P53 gene mutations in breast cancer. Abstract [Details]
Chin, D., Duffy, M. J., Willcocks, T., Gallagher, W., O Higgins, N., and Parfrey, N.; (1994) P53 gene mutations in breast cancer. Abstract [Details]
Gallagher, W. M., and Grant, G. H.; (1993) Structural basis of p21H-ras molecular switch inhibition by a neutralizing antibody. Abstract [Details]
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Articles

Chin, D., Duffy, M. J., Willcocks, T., Gallagher, W., O Higgins, N., and Parfrey, N.; (1994) Detection of mutations in p53 gene in breast cancer by single stranded conformation polymorphism. Articles [Details]

Honours and Awards

Year: 2006.
Title: JMS Doctor Awards 2006 - Finalist in Oncology Section

Year: 2005.
Title: JMS Doctor Awards 2005 - Finalist in Oncology Section

Year: 2004.
Title: BACR/AstraZeneca

Year: 2003.
Title: JMS Doctor Award

Year: 2000.
Title: BACR/Hamilton-Fairley

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Associations

Association: The Biochemical Society (Date of election 01-10-93), Function/Role: *

Association: American Association for Cancer Research Active Member (Jan 2004 Present), Function/Role: *

Association: Associate Editor of MCFA News (Oct 2002 Present), Function/Role: *

Association: Deputy Co-Ordinator of the Conway Institute Cancer Biology Group (Jul 2002-Present), Function/Role: *

Association: Expert on the following Conway Institute Core Activity Units: Transcriptomics/ Bioinformatics/Information Technology (July 2002 Present) , Function/Role: *

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Patents

Patent US20040005646 : Use of the S2-6 gene product as a diagnostic marker for cancer detection.

Patent PCT/GB2006/0007 : Markers for Melanoma - UK Patent Application

Patent GB 0604370.7 : Markers for Melanoma

Patent PCT/US07/68619 : Methods and compositions for identifying and using p21-regulated proteins.

Patent 03/080627 : Compounds useful as photodynamic therapeutic agents.

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Conference Contributions

Brennan, D. J., Rexhepaj, E., Jirstrom, K., Kronblad, A., Fagan, A., Culhane, A. C., Millikan, R. C., Landberg, G., Duffy, M. J., Rydén, L., Higgins, D. G., O'Brien, S. L., and Gallagher, W. M. ; (2007) Validation of novel breast cancer biomarkers arising from re-analysis of publicly available 'omic datasets via tissue microarrays and automated quantitative scoring models for immunohistochemistry. [Oral Presentation], Oncogenomics 2007: Dissecting Cancer Through Genome Research,, Phoenix, AZ , 31-JAN-07 - 03-FEB-07.

W. M. Gallagher; (2007) Validation of protein biomarkers via tissue microarray technology. [Keynote Address], Cancer Proteomics World Congress, Philadelphia , 26-APR-07 - 27-APR-07.

O'Connor, D. P., O'Donoghue, N., Currid, C. A., Chang, B.-D., Roninson, I. B., Dunn, M. J., Pennington, S. R., and Gallagher, W. M. ; (2006) p21, p16 and p27, more than just cell cycle inhibitors. [Poster Presentation], Irish Association for Cancer Research/Irish Society for Medical Oncology - Joint Annual Cancer Research Meeting, Galway , 03-MAR-06 - 04-MAR-06.

Gallagher, W. M. ; (2006) Global mRNA and Protein Expression Analysis Conference. [Invited Lecture], ABI Lecture ' Gene expression profiling of malignant melanoma, Dublin City University , 07-NOV-06 - 08-NOV-06.

Brennan, D. J., Rexhepaj, E., Jirstrom, K., Kronblad, A., Fagan, A., Culhane, A. C., Millikan, R. C., Landberg, G., Duffy, M. J., Rydén, L., Higgins, D. G., O'Brien, S. L., and Gallagher, W. M. ; (2006) Validation of novel breast cancer biomarkers arising from re-analysis of publicly available 'omic datasets via tissue microarrays and automated quantitative scoring models for immunohistochemistry. [Invited Lecture], International Cancer Biomarker Consortium Member Meeting, Singapore , 02-DEC-06 - 03-DEC-06.

Gallagher, W.M.; (2006) Experiences with SELDI at the Conway Institute. [Oral Presentation], SELDI Discussion Day, Merck, Frankfurt , 20-FEB-06.
Gallagher, W. M. ; (2006) Biomarker discovery via the SELDI platform: case studies in the cancer arena. [Invited Lecture], The Biomarker Discovery Event: Leveraging multiplex experimental technologies for drug development, Basel , 10-FEB-06.
Gallagher, W. M.; (2005) Biomarker identification and validation in breast cancer. [Invited Lecture], Ordway Research Institute, Albany , 14-JUN-05.
Gallagher, W. M. ; (2005) Transcriptomic analysis of cellular phenotypic responses: lessons learned from studies of cell-biomaterial interaction and cancer-associated phenomena. [Invited Lecture], Workshop on 'Development of a platform and toolkit for understanding, preventing, and exploiting interactions between nanoparticles and the living world' (NanoToxTools),, University College Dublin , 18-AUG-05.
Gallagher, W. M. ; (2005) Proteomic investigation via SELDI-MS technology: application to cancer biology. [Invited Lecture], FOCAS Institute ' SFI UREKA Site Review Day, DIT Kevin Street , 04-NOV-05.
Gallagher, W. M.; (2005) SELDI facility: an update. [Oral Presentation], ProteinChip Seminar Day, University College Dublin , 17-NOV-05.
Gallagher, W. M. ; (2005) UCD consolidated submission. [Oral Presentation], PRTLI Imaging Initiative Workshop, Royal College of Surgeons in Ireland , 05-DEC-05.
Gallagher, W. M.; (2005) Breast cancer: a functional genomics perspective. [Invited Lecture], Breast Cancer Research Consortium,, DMMC , 19-MAY-05.
Gallagher, W. M. ; (2005) Proteomic investigations via ProteinChip and tissue microarray technology. [Invited Lecture], Proteomic investigations via ProteinChip and tissue microarray technology, The Adelaide and Meath Hospital, Dublin , 15-FEB-05.
Gallagher, W. M.; (2005) Proteomic investigations via ProteinChip and tissue microarray technology. [Invited Lecture], Microbiology Department, Moyne Institute, Trinity College Dublin , 18-FEB-05.
Gallagher, W. M. ; (2005) Gene expression profiling in cancer: DNA microarrays and beyond. [Invited Lecture], Gene Expression Profiling in Cancer Mini-Symposium, St. James¿s Hospital, Dublin , 26-FEB-05.
Gallagher, W. M. ; (2005) Multiple markers of melanoma progression regulated by DNA methylation: insights from transcriptomic studies. [Invited Lecture], Gene Signatures Symposia '05, Royal College of Obstetricians and Gynaecologists, London , 03-MAR-05.
Gallagher, W. M.; (2004) p21: central role in cancer and age-related disorders. [Oral Presentation], ProteinChip Technology: Application to Biomedical Research, Dublin , 19-OCT-04.
Gallagher, W. M.; (2004) Melanoma progression and DNA methylation: insights from transcriptomic studies. [Oral Presentation], Conway Cancer Biology Group Meeting, Dublin , 04-OCT-04.
Gallagher, W. M.; (2004) Fibulins: physiological and disease perspectives. [Invited Lecture], Manchester, British Cancer Research Meeting 2004 , 27-JUN-04 - 30-JUN-04.
Gallagher, W. M.; (2004) From genes to proteins: from genomics to proteomics. [Oral Presentation], SFI Cancer Workshop, St. James¿s Hospital ¿ Institute of Molecular Medicine , 13-MAY-04 - 14-MAY-04.
Gallagher, W. M.; (2004) Our experience with SELDI technology: two case studies. [Invited Lecture], Ciphergen Biosystems: Biomarkers to Assays Symposium, Milan , 18-MAY-04.
Bergin, O. E., Gallagher, W. M., Kelly, Z. D., Fox, E. J. P., McArdle, L., Currid, C. A., Ilse-Maria Nolan, O' Mahony, F., Byrne, A., Murphy, A. A., Stallings, R. L., Plumb, J. A., Brown, R., Dervan, P. A., and Easty, D. J. ; (2004) Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies. [Poster Presentation], 16th Pezcoller Symposium 2004 'Stem Cells and Epigenesis in Cancer', Trento , 10-JUN-04 - 12-JUN-04.
Gallagher, W. M. ; (2004) Gene expression profiling in cancer: mechanistic insights and biomarker discovery. [Oral Presentation], Gene expression profiling in cancer: mechanistic insights and biomarker discovery, Georg-Speyer-Haus, Frankfurt , 02-JUN-04.
Gallagher, W. M. ; (2004) Serum biomarkers for breast cancer identified by ProteinChip technology. [Invited Lecture], European ProteinChip Symposium & User Meeting, The Gresham Hotel, Dublin , 05-MAY-04 - 06-MAY-04.
Gallagher, W. M. ; (2003) Gene expression profiling in cancer: mechanistic insights and biomarker discovery. [Invited Lecture], Conference on 'Common Molecular Mechanisms in Inflammation & Malignancy',, St. Vincent¿s University Hospital, Dublin , 21-NOV-03.
Gallagher, W. M. ; (2003) The genomics revolution: past, present and future. [Invited Lecture], Irish Research Scientists' Association ' Public Symposium on 'Science and Society', National University of Ireland ¿ Maynooth , 13-NOV-03.
Gallagher, W. M., O' Shea, C. M., Gorman, A., Killoran, J., and O' Shea, D. F.; (2003) Tetraarylazadipyrromethenes: a novel class of photosensitising compounds. [Oral Presentation], Irish Association of Pharmacologists 14th Annual Meeting, Dublin , 10-OCT-03.
Gallagher, W. M. ; (2003) DNA microarray-based transcriptome analysis: applications in cancer and biomaterials research. [Invited Lecture], National Centre for Biomedical Engineering Science, National University of Ireland ¿ Galway , 23-JUL-03.
Gallagher, W. M.; (2003) Gene expression profiling in cancer: insights into tumour biology and therapeutic implications. [Invited Lecture], Symposium on DNA Arrays: More Answers than Questions?,, Royal College of Surgeons in Ireland, Dublin , 23-MAY-03.
Gallagher, W. M.; (2003) Gene and protein expression profiling in cancer: insights into tumour biology and therapeutic implications. [Invited Lecture], Department of Molecular Genetics Seminar Series, University of Illinois at Chicago, University of Illinois at Chicago , 12-MAR-03.
Gallagher, W. M.; (2003) Protein expression profiling in cancer via ProteinChip technology: case studies. [Invited Lecture], 1st Centre for Integrative Biology Symposium, University College Dublin, University College Dublin , 20-FEB-03.
Gallagher, W. M.; (2003) Gene and protein expression profiling in cancer: insights into tumour biology and therapeutic implications. [Invited Lecture], Department of Cell Biology and Anatomy Seminar Series, Medical University of South Carolina, South Carolina , 03-FEB-03.
Gallagher, W. M., Bergin, O. E., Kelly, Z. D., McArdle, L., Fox, E. J. P., Currid, C. A., O Mahony, F., Byrne, A., Murphy, A. A., Stallings, R. L., Dervan, P. A., and Easty, D. J.; (2003) Transcriptome patterns in malignant melanoma: correlation with phenotypic, genomic and epigenetic alterations. [Poster Presentation], Oncogenomics 2003, Phoenix, Phoenix , 20-JAN-03 - 02-FEB-03.
Gallagher, W. M.; (2003) DNA microarray-based transcriptome analysis: applications in cancer and biomaterials research. [Invited Lecture], National Centre for Biomedical Engineering Science, National University of Ireland Galway, 23 July 2003, Galway , 23-JUL-03.
Cannon, G. A., Donoghue, S. E., Mackin, D. J., Easty, D. J., and Gallagher, W. M. presented by G. A. Cannon.; (2003) A paradigm approach for high-throughput functional validation of candidate tumour-associated gene families: protein tyrosine phosphatases as a case study. [Poster Presentation], Biotechnology, Cancer & Drug Resistance Conference, National Institute for Cellular Biotechnology, Dublin , 07-JUL-03 - 08-JUL-03.
Greene, L. M., Reed, B., Knaak, C., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2003) Fibulin-1 variant-specific effects on cellular migration and global protein expression in HT1080 fibrosarcoma cells. [Poster Presentation], Biotechnology, Cancer & Drug Resistance Conference at the National Institute for Cellular Biotechnology, Dublin , 07-JUL-03 - 08-JUL-03.
Tosetto, M., Allen, L. T., Dawson, K. A., and Gallagher, W. M. presented by M. Tosetto.; (2003) Cell-biomaterial interactions: evaluation of biological responses to chiral polymers. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Allen, L. T., Fox, J. P. E., Kelly, Z. D., Rochev, Y., Keenan, A. K., Dawson, K., and Gallagher, W. M. presented by L. T. Allen.; (2003) Cell-biomaterial interactions: phenotype/transcriptome correlations. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Tosetto, M., Allen, L. T., Dawson, K. A., and Gallagher, W. M. presented by M. Tosetto.; (2003) Cell-biomaterial interactions: evaluation of biological responses to chiral polymers. [Poster Presentation], Irish Association of Pharmacologists 14th Annual Meeting, Dublin , 10-OCT-03.
Kavanagh, C. A., Rochev, Y., Gorelov, A. V., Gallagher, W. M, and Keenan, A. K. presented by C. A. Kavanagh.; (2003) Surface expression of ICAM-1 on human endothelial cells grown on potential intra-vascular stent coatings. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Expression levels of fibulin-1 and 4 mRNA in colon cancer tissues determined by real-time quantitative reverse transcriptase-PCR. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
O Shea, C. M., Gorman, A., Killoran, J., Gallagher, W. M, and O Shea, D. F. presented by C. M. O Shea.; (2003) BF2 chelated tetraarylazadipyrromethene (ADPM) photosenitisers: cellular uptake, efflux and cytotoxicity in human cancer cells. [Oral Presentation], Irish Association for Cancer Research Annual Meeting, Cork , 11-APR-03 - 13-APR-03.
O Brien, S., Fox, E. J. P., de Gardelle, I., Reed, B., Duffy, M. J., and Gallagher, W. M. presented by S. O Brien.; (2003) Serum biomarkers for breast cancer identified via ProteinChip technology. [Oral Presentation], Irish Association for Cancer Research Annual Meeting, Cork , 11-APR-03 - 13-APR-03.
O Shea, C. M., Gorman, A., Killoran, J., Gallagher, W. M., and O Shea, D. F. presented by C. M. O Shea.; (2003) Tetraarylazadipyrromethenes: a novel class of photosensitising compounds. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
McArdle, L., McDermott, M., O Meara, A., Breatnach, F., Gallagher, W. M., and Stallings, R. L. presented by L. McArdle.; (2003) Gene expression profiling of neuroblastomas. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Lou, Y., Rehmann, F. J. K., Mendoza, O., Cuffe, L., Tacke, M., Allen, L. T., and Gallagher, W. M. presented by F. J. K. Rehmann.; (2003) Synthesis of novel titanocenes as possible anti-cancer drugs. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Currid, C. A., Greene, L. M., Corbit, K. C., and Gallagher, W. M. presented by C. A. Currid.; (2003) Fibulin-4: physiological and pathophysiological roles. [Oral Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Lou, Y., Rehmann, F. J. K., Sweeney, N., Mendoza, O., Cuffe, L., Tacke, M., Allen, L. T., and Gallagher, W. M. presented by F. J. K. Rehmann.; (2003) Synthesis of novel titanocenes as possible anti-cancer drugs. [Poster Presentation], Conference on Common Molecular Mechanisms in Inflammation & Malignancy, St. Vincent?s University Hospital, Dublin , 21-NOV-03.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Biomarker identification in colon cancer via real-time reverse transcriptase-PCR. [Poster Presentation], Conference on Common Molecular Mechanisms in Inflammation & Malignancy, St. Vincent?s University Hospital, Dublin , 21-NOV-03.
O Shea, C. M., Gorman, A., Kenna, T., Killoran, J., Gallagher, W. M., and O Shea, D. F. presented by T. Kenna.; (2003) Tetraarylazadipyrromethenes: a novel class of photosensitising agent. [Poster Presentation], Common Molecular Mechanisms in Inflammation & Malignancy, St. Vincent?s University Hospital, Dublin , 21-NOV-03.
Duggan, S., Abdel-latif, M., Gallagher, W. M., Reynolds, J., and Kelleher, D. presented by S. Duggan.; (2003) . [Oral Presentation], Spring 2003 Meeting Irish Society of Gastroenterology*, Belfast , 06-JUN-03 - 07-JUN-03.
Nolan, I. M., Fox, E. J. P., Kelly, Z. D., Moss, C., Sheahan, K., O Donoghue, D., Argraves, W. S., and Gallagher, W. M. - presented by I. M. Nolan.; (2003) Expression levels of fibulin-1 and 4 mRNA in colon cancer tissues determined by real-time quantitative reverse transcriptase-PCR. [Poster Presentation], Biotechnology, Cancer & Drug Resistance Conference, National Institute for Cellular Biotechnology, Dublin , 07-JUL-03 - 08-JUL-03.
Cannon, G. A., Donoghue, S. E., Morris, A. M., Mackin, D. J., Easty, D. J., and Gallagher, W. M. presented by G. A. Cannon.; (2003) A paradigm approach for high-throughput functional validation of candidate tumour-associated gene families: protein tyrosine phosphatases as a case study. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
O Brien, S., Fox, E. J. P., Culhane, A. C., Duffy, M. J., and Gallagher, W. M. presented by S. O Brien.; (2003) DNA microarray data analysis and validation using between group analysis: a focus on breast cancer. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
O Shea, C. M., Gorman, A., Killoran, J., Gallagher, W. M., and O Shea, D. F. presented by C. M. O Shea.; (2003) BF2 chelated tetraarylazadipyrromethene (ADPM) photosensitisers: cellular uptake, efflux and cytotoxicity in human cancer cells. [Poster Presentation], Conference on Apoptosis from Laboratory Bench to the Clinic, University College Cork, Cork , 06-JUN-03 - 07-JUN-03.
Gallagher, W. M.; (2002) Gene and protein expression profiling in cancer: insights into tumour development and progression. [Invited Lecture], Molecular Medicine Series, St. Jamess Hospital, St. James?s Hospital , 11-NOV-02.
Gallagher, W. M.; (2002) From genes to GeneChips: the automatisation of biological investigation. [Invited Lecture], Institute of Electrical Engineers (IEE) Seminar Series, University College Dublin, 10 October 2002, University College Dublin , 10-OCT-02.
Bergin, O. E., Gallagher, W. M., Kelly, Z. D., Fox, E. J. P., Currid, C. A., Dervan, P. A., and Easty, D. J. presented by O. E. Bergin.; (2002) Identification of candidate markers for melanoma progression. [Poster Presentation], British Cancer Research Meeting 2002, Glasgow , 30-JUN-02 - 03-JUL-02.
Kelly, Z. D., Barth, J. L., Fox, E. J. P., Greene, L. M., Knaak, C., Murphy, A. A., Argraves, W. S., and Gallagher, W. M. presented by Z. D. Kelly.; (2002) Gene expression profile analysis of tumor-derived cell lines overexpressing the candidate tumor suppressor gene, fibulin-1. [Oral Presentation], British Cancer Research Meeting 2002, Glasgow , 30-JUN-02 - 03-JUL-02.
Kavanagh, C. A., Rochev, Y., Gorelov, A., Gallagher, W. M., and Keenan, A. K. presented by C. A. Kavanagh.; (2002) Biocompatibility of thermoresponsive N-isopropylacrylamide co-polymers: interaction with vascular endothelial cells. [Oral Presentation], Royal Academy of Medicine in Ireland Summer Meeting, Belfast , 19-JUN-02 - 20-JUN-02.
Greene, L. M., Twal, W. O., McDermott, E., O Higgins, N., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2002) Proteolysis of human fibulin-1 in breast carcinomas and in vitro. [Oral Presentation], British Cancer Research Meeting 2002, Glasgow , 30-JUN-02 - 03-JUL-02.
Doorty, K. B., Golubeva, T., Gorelov, A., Rochev, Y., Dawson, K., Gallagher, W. M., and Keenan, A. K. presented by A. K. Keenan.; (2002) Investigation of co-polymer films as drug delivery systems for prevention of vascular smooth muscle cell proliferation. [Poster Presentation], ISACB 2002, St. Gallen , 27-FEB-02 - 02-MAR-02.
Kelly, Z. D., Barth, J. L, Fox, E. J. P., Greene, L. M., Knaak, C., Argraves, W. S., and Gallagher, W. M.; (2002) Gene expression profile analysis of tumor-derived cell lines overexpressing the candidate tumor suppressor gene, fibulin-1. [Poster Presentation], American Association for Cancer Research, 93rd Annual Meeting, San Francisco, San Francisco , 06-APR-02 - 10-APR-02.
Gallagher, W. M., Bergin, O. E., Kelly, Z. D., Fox, E. J. P., Currid, C. A., Dervan, P. A., and Easty, D. J.; (2002) Candidate markers for melanoma progression identified using a gene expression profiling approach. [Poster Presentation], Oncogenomics 2002: Dissecting Cancer Through Genome Research, Dublin, Dublin , 01-MAY-02 - 05-MAY-02.
Nolan, I. M., Fox, E. J. P., Kelly, Z. D., Moss, C., Sheahan, K., O Donoghue, D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2002) Expression levels of fibulin-1 and 4 mRNA in colon cancer tissues determined by real-time quantitative reverse transcriptase-PCR. [Poster Presentation], 2nd Annual Conway Institute Festival of Research, Dublin , 12-SEP-02.
Kavanagh, C. A., Rochev, Y., Gorelov, A., Gallagher, W. M., and Keenan, A. K. presented by C. A. Kavanagh.; (2002) Thermoresponsive co-polymers as surfaces for endothelial cell growth. [Poster Presentation], Irish Angiology Third Annual Conference, Belfast , 29-NOV-02 - 30-NOV-02.
Kavanagh, C. A., Rochev, Y. Dawson, K. A., Gallagher, W., and Keenan, A. K. presented by C. A. Kavanagh.; (2002) Carboxymethylated dextran: A potential protein delivery system for use in the prevention of restenosis. [Oral Presentation], Royal Academy of Medicine in Ireland Winter Meeting, Dublin , 04-JAN-02.
Greene, L. M., Twal, W. O., Foley, D. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2002) Dysregulated expression and proteolysis of fibulin-1 in human breast tumors. [Poster Presentation], American Association for Cancer Research, 93rd Annual Meeting, San Francisco , 06-APR-02 - 10-APR-02.
Gallagher, W.; (2001) The Impact of Genetics on Science and Society . [Conference Organising Committee Member], 1st July 2001 - University College Dublin (Main Conference Organiser - in association with the Marie Curie Fellowship Association) http://www.mariecurie.org , University College Dublin , 01-JUL-01.
Gallagher, W.; (2001) Functional Genomics and Proteomics: Impact on Therapeutic Strategies. [Conference Organising Committee Member], 2nd July 2001 University College Dublin (Co-Organiser in association with the MCFA, Elan Corporation and the British Pharmacological Society) http://www.bps.ac.co.uk Co-organised Trade Exhibit during BPS 2001 Annual Meeting (2nd 5th July 2001) , University College Dublin , 02-JUL-01.
Greene, L. M., Twal, W. O., Donovan, N. O., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2001) Proteolytic processing of fibulin-1 is linked with estrogen receptor status in human breast tumours and tumour-derived cell lines. [Poster Presentation], The Irish Association for Cancer Research/Irish Society of Medical Oncology Joint Cancer Research Meeting, Cork , 27-SEP-01 - 28-SEP-01.
Kelly, Z. D., Barth, J. L., Fox, E. J. P., Greene, L. M., Knaak, C., Argraves, W. S., and Gallagher, W. M. presented by Z. D. Kelly. Ms. Kelly won an IACR Young Scientist Award on the basis of this presentation.; (2001) DNA microarray-based gene expression profile analysis of tumour-derived cell lines overexpressing fibulin-1, a candidate tumour suppressor gene. [Oral Presentation], The Irish Association for Cancer Research/Irish Society of Medical Oncology Joint Cancer Research Meeting*, Cork , 27-SEP-01 - 28-SEP-01.
Allen, L., Rotchev, Iu., Golubeva, T., Selezneva, I., Gorelov, A., Dawson, K., and Gallagher, W. M. presented by L. Allen.; (2001) Surface hybrophobicity of acylamide co-polymers: influence on cell behaviour. [Poster Presentation], 1st Annual Conway Institute Festival of Research, Dublin , 13-SEP-01.
Kelly, Z. D., Barth, J. L., Fox, E. J. P., Greene, L. M., Knaak, C., Argraves, W. S., and Gallagher, W. M. presented by Z. D. Kelly.; (2001) DNA microarray-based gene expression profile analysis of tumour-derived cell lines overexpressing fibulin-1, a candidate tumour suppressor gene. [Poster Presentation], 1st Annual Conway Institute Festival of Research, University College Dublin , 13-SEP-01.
Doorty, K. B., Golubeva, T., Gorelov, A., Rochev, Y., Dawson, K., Gallagher, W. M., and Keenan, A. K.; (2001) . [Poster Presentation], 1st Conway Institute Festival of Research, Dublin*, Dublin , 13-SEP-01.
Gallagher, W. M.; (2001) Cancer biology. [Invited Lecture], 1st Conway Institute Festival of Research, Dublin, 13 September 2001, Dublin , 13-SEP-01.
Greene, L. M., Twal, W. O., Donovan, N. O., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M.; (2001) Proteolytic processing of fibulin-1 is linked with estrogen receptor status in human breast tumours and tumour-derived cell lines. [Oral Presentation], The Irish Association for Cancer Research/Irish Society of Medical Oncology Joint Cancer Research Meeting, Cork, Cork , 27-SEP-01 - 28-SEP-01.
Gallagher, W. M. .; (2001) Gene expression profiling in the Conway Institute: The story so far. [Invited Lecture], Conway Core Technology Seminar, Dublin, Dublin , 25-OCT-01.
Allen, L., Rochev, Y., Golubeva, T., Gorelov, A., Selezneva, I., Gavrilyuk, B., Dawson, K., and Gallagher, W. M. presented by L. Allen.; (2001) Role of surface hydrophobicity in determining phenotypic responses of cells to biomaterial interactions. [Poster Presentation], Irish Association of Pharmacologists Annual Meeting, Killiney , 02-NOV-01.
Doorty, K. B., Golubeva, T., Gorelov, A., Rochev, Y., Dawson, K., Gallagher, W. M., and Keenan, A. K. presented by K. B. Doorty.; (2001) Investigation of co-polymer films as drug delivery systems for prevention of vascular smooth muscle cell proliferation. [Poster Presentation], Irish Angiology Society Second Annual Conference, Dublin , 01-NOV-01 - 03-NOV-01.
Greene, L. M., Twal, W. O., Donovan, N. O., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2001) . [Poster Presentation], 1st Annual Conway Institute Festival of Research*, Dublin , 13-SEP-01.
Kelly, Z. D., Barth, J. L., Fox, E. J. P., Greene, L. M., Knaak, C., Argraves, W. S., and Gallagher, W. M. presented by Z. D. Kelly.; (2001) DNA microarray-based gene expression profile analysis of tumour-derived cell lines overexpressing fibulin-1, a candidate tumour suppressor gene. [Poster Presentation], BACR Special Conference - Forging an alliance between genomics, proteomics and chemical biology to accelerate cancer drug discovery, Buckinghamshire , 09-SEP-01 - 11-SEP-01.
Doorty, K. B., Golubeva, T., Gorelov, A., Rochev, Y., Dawson, K., Gallagher, W. M., and Keenan, A. K. presented by K. B. Doorty.; (2001) Investigation of co-polymer films as drug delivery systems for prevention of vascular smooth muscle cell proliferation. [Poster Presentation], British Pharmacological Society Summer Meeting, Dublin , 03-JUL-01 - 05-JUL-01.
Greene, L. M., Twal, W. O., Maguire, T., McCann, A., Dervan, P., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2001) Proteolytic processing of fibulin-1 in human breast tumors is linked with estrogen receptor status. American Association for Cancer Research. [Poster Presentation], 92nd Annual Meeting, New Orleans , 24-MAR-01 - 28-MAR-01.
Gallagher, W. M.; (2000) The fibulins: novel regulators of cell growth and motility. [Invited Lecture], 5th Annual Meeting of the Institute of Molecular Medicine, Dublin, Dublin , 10-NOV-00 - 11-NOV-00.
Gallagher, W. M., Greene, L. M., Strachan, S. M., Ryan, M. P., Sierra, V., Debussche, L., and Conseiller, E.; (2000) Isolation and characterisation of the candidate human oncogene, fibulin-4. [Oral Presentation], The Irish Association for Cancer Research/Irish Society of Medical Oncology Joint Cancer Research Meeting, Galway, Galway , 14-APR-00 - 15-APR-00.
Gallagher, W. M., Greene, L. M., Strachan, S. M., Ryan, M. P., Sierra, V., Debussche, L., and Conseiller, E.; (2000) cDNA isolation, chromosomal localisation, and biochemical characterisation of the candidate human oncogene, fibulin-4. [Oral Presentation], British Cancer Research Meeting 2000, Brighton Dr. Gallagher won the BACR/Hamilton-Fairley Young Investigator Award 2000 on the basis of this oral presentation*, Brighton , 09-JUL-00 - 12-JUL-00.
Gallagher, W. M.; (2000) Fibulins and cancer: analysis of expression profiles using DNA microarray-based approaches. [Oral Presentation], EMBO Practical Course Functional genomics using high-density array and microarray technology, Berlin , 11-SEP-00 - 22-SEP-00.
Gallagher, W. M., Argentini, M., Sierra, V., Bracco, L., Debussche, L., and Conseiller; (1999) E. MBP1, a new member of the fibulin gene family with both mutant p53-dependent and -independent oncogenic properties. [Poster Presentation], American Association for Cancer Research, 90th Annual Meeting, Philadephia, Philadephia , 10-APR-99 - 14-APR-99.
Gallagher, W. M., Sierra, V., and Conseiller, E.; (1999) MBP1, a novel mutant p53-specific partner and candidate oncoprotein. [Poster Presentation], Journeé de lInnovation (Rhône-Poulenc Rorer), Vitry-sur-Seine, Vitry-sur-Seine , 18-MAY-99.
Gallagher, W. M.; (1996) Low molecular mass modifiers of the p53 response. [Oral Presentation], Drug Resistance Autumn Workshop, Glasgow , 05-SEP-96 - 06-SEP-96.
Gallagher, W., Gudkov, A. V., Roninson, I. B., and Brown, R.; (1996) Genetic suppressor elements from TP53 cDNA inducing cisplatin resistance in a human ovarian adenocarcinoma line. [Poster Presentation], American Association for Cancer Research, 87th Annual Meeting, Washington, 20-24 April 1996 [P], Washington , 20-APR-96 - 24-APR-96.
Gallagher, W. M.; (1996) Cell cycle related expression of p53 and cyclin B1 protein in cisplatin resistant ovarian adenocarcinoma cell lines. [Oral Presentation], BACR Flow Cytometry Workshop on Cell Cycle Related Proteins, Edinburgh, Edinburgh , 03-APR-96.
Gallagher, W. M., Gudkov, A. V., Roninson, I. B., and Brown, R.; (1996) Genetic suppressor elements from TP53 cDNA inducing cisplatin resistance in a human ovarian adenocarcinoma line. [Poster Presentation], 8th International p53 Workshop, Dundee, Dundee , 05-JUL-96 - 09-JUL-99.
Gallagher, W. M.; (1995) Molecular dissection of p53 function via genetic suppressor element technology. [Oral Presentation], Drug Resistance Autumn Workshop, Newcastle, Newcastle , 28-SEP-95 - 29-SEP-95.
Gallagher, W., McIlwrath, A., Edlin, A., Vasey, P., and Brown.; (1995) P53 mediated cell cycle arrests and apoptosis induced by the anti-cancer drug cis-diamminedichloroplatinum (II). [Poster Presentation], Biochemical Society Meeting No. 656, Dublin , 11-SEP-95 - 14-SEP-95.
Gallagher, W. M., Edlin, A., McIlwrath, A., Vasey, P., and Brown R.; (1995) Defective p53 function correlates with increased cisplatin resistance in human ovarian cancer. [Poster Presentation], Gordon Research Conference on Cancer: Molecular Targets for Cancer Therapy, Newport, Newport , 06-AUG-95 - 11-AUG-95.
Gallagher, W., Edlin, A., and Brown, R.; (1995) Analysis of the p53-mediated DNA-damage response pathway in a cisplatin-resistant ovarian carcinoma line. [Oral Presentation], British Association for Cancer Research, 36th Annual Meeting, Nottingham, 2-5 April 1995 [O], Nottingham , 02-APR-95 - 05-APR-95.
Gallagher, W. M., Edlin, A., Vasey, P., McIlwrath, A., and Brown, R.; (1994) Dependence of wild-type p53 function for sensitivity of human ovarian tumour lines to DNA-damaging agents. [Poster Presentation], UK Molecular Biology and Cancer Network, 11th Annual Meeting, Coventry, Coventry , 12-DEC-94 - 14-DEC-94.
Gallagher, W. M.; (1994) The isolation of genetic suppressor elements involved in recessively-acting mechanisms of drug resistance. [Oral Presentation], Drug Resistance Autumn Workshop, London, 15-16 September 1994, London , 15-SEP-94 - 16-SEP-94.
Gallagher, W. M., and Grant, G. H. ; (1993) Structural basis of p21H-ras molecular switch inhibition by a neutralizing antibody. . [Poster Presentation], Biochemical Society Meeting No. 651, London, London , 19-DEC-93 - 22-DEC-93.
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Committees

Committee : UCD Research Computing Steering Group

Committee : SFI Cancer Committee

Committee : PRTLI Imaging Initiative

Committee : Conway Institute Cancer Biology Group

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Employment

Employer: AVENTIS Pharma, France
Position: Marie Curie Research Fellow

Employer: University College Dublin
Position: Enterprise Ireland Research Fellow

Employer: Conway Institute
Position: Core Investigator

Employer: Marie Curie Fellowship Association
Position: National Co-Ordinator

Employer: University College Dublin
Position: Marie Curie Return Fellow

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Education

Year 1993 Institution: University College Dublin
Qualification: BSc Subject:

Year 1996 Institution: University of Glasgow, Scotland
Qualification: PhD Subject:

Languages

English:

Irish:

French:

German:

Outreach Activities

I also participate in outreach activities to primary and secondary level students, with a view to fostering an interest in science.

Internal Collaborators

Dr. Mairin Rafferty
Dr. Sallyann O'Brien
Dr. Linda Whelan
Dr. Darran O'Connor
Dr. Richard Talbot
Dr. Annette Byrne
Dr. Donal Brennan
Prof. Finian Martin

External Collaborators

Dr. Helen Roche
St. James's Hospital & Trinity College Dublin

Prof. Dermot Kelleher
St. James's Hospital, Trinity College Dublin

Ryan, D., Mulrane, L., Rexhepaj, E., and Gallagher, W. M. ; (2008) 'Tissue microarrays and digital image analysis' In: Jean-Charles Gautier (eds). Methods in Molecular Medicine - Drug Safety Evaluation. Humana Press: N/A. [Details]
Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson R. W., Cunningham, P., Gallagher, W. M.; (2008) 'Automated image analysis approaches in histopathology' In: Handbook of Research on Systems Biology Applications in Medicine. Berlin, Germany: Andriani Daskalaki, Max Planck Institute for Molecular Genetics. [Details]
Kelly, C. M. A., Ryan, D., Penny, S., Gallagher, W. M. ; (2008) 'Systematic validation of breast cancer biomarkers using tissue microarrays: from construction to image analysis' In: Volume 1 of Cancer Diagnosis, Therapy, and Prognosis. N/A: M. A. Hayat. [Details]
Whelan, L. C., Cooney, H. C., Gallagher, W. M; (2009) 'Fibulins' In: Encyclopedia of Cancer, 2nd Edition. N/A: Springer-Verlag Berlin and Heidelberg GmbH & Co. [Details]
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Year: 2000. Title: Marie Curie Return Fellowship
Year: 1999. Title: Enterprise Ireland Postdoctoral Fellowship
Year: 1997. Title: Marie Curie Research Training Grant
Year: 1996. Title: Bristol-Myers Squibb Oncology Award
Year: 1993. Title: Cancer Research Campaign PhD Studentship
Year: 0. Title: First Position in Molecular Genetics
Year: 1993. Title: Second Position in Biochemistry Class
Year: 1992. Title: Wellcome Trust Summer Vacation Scholarship
Year: 1989. Title: Mount Sion CBS Gold Medal Award
Year: 0. Title: Travel Award
Year: 0. Title: Travel Award
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Association: Lead Co-Ordinator of the Conway Institute Cancer Biology Group (Oct 2001 to Jul 2002), Function/Role: *
Association: Member of Conway Institute Transcriptomics Management Committee (Jan 2000 to Dec 2001), Function/Role: *
Association: Council Member of the Irish Association for Cancer Research (Date of election 14-04-00), Function/Role: *
Association: Co-Ordinator of the Marie Curie Fellowship Association Irish Section (since 1999), Function/Role: *
Association: Irish Association for Cancer Research (since 1999), Function/Role: *
Association: Marie Curie Fellowship Association (Date of election 28-04-99), Function/Role: *
Association: Institute of Biology (Date of election 25-03-99), Function/Role: *
Association: British Association for Cancer Research (Date of election 02-04-95), Function/Role: *
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Committee : Conway Institute subgroups, including Transcriptomics, Proteomics, Bioinformatics and Histology
Committee : Health Research Board: Molecular, Cellular and Developmental Biology Committee
Committee : Health Research Board: Genomics, Proteomics and Human Disease Committee
Committee : Enterprise Ireland Basic Research Grant Committee
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Employer: University College Dublin Position: College Lecturer
Employer: Conway Institute Position: Lead Co-ordinator
Employer: Conway Institute Position: Deputy Co-ordinator
Employer: U.C.D. Position: Associate Professor of Cancer Biology
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Patent WO0022120 : (MBP1) polypeptides capable of interacting with oncogenic mutants of the p53 protein.
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