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Wim Meijer

School of Biomolecular & Biomedical Science
Room G009
Conway Institute
School of Biomolecular & Biomedical Science
University College Dublin
Dublin 4, Ireland

Tel: (+353)17166825
Email: wim.meijer@ucd.ie

Biography

2006 Associate Professor of Microbiology, University College Dublin
2005-2013 Subject Head Microbiology, UCD School of Biomolecular and Biomedical Science, University College Dublin
2002-2006 Senior Lecturer, UCD School of Biomolecular and Biomedical Science and Conway Institute, National University of Ireland, Dublin, Ireland
1997-2002 Lecturer, Department of Microbiology, National University of Ireland, Dublin, Ireland
1991-1997 Lecturer, Department of Microbiology, University of Groningen, The Netherlands
1990-1991 Postdoctoral Researcher Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
1990 Ph.D. Faculty of Mathematics and Natural Sciences; University of Groningen, The Netherlands.

Professor Meijer graduated in 1986 from the University of Groningen, The Netherlands with an MSc in Biology. He obtained his PhD from the same University, following research on the physiology and molecular biology of autotrophic CO2 fixation. Following completion of his PhD in 1990, he joined the research team of Professor Tabita, Ohio Eminent Scholar at The Ohio State University, USA, to study the regulation of microbial gene expression at the molecular level. In 1991 Dr. Meijer was appointed as Lecturer in Microbiology at the University of Groningen, where he continued his research on the molecular biology and physiology of microbial metabolism and the regulation of gene expression.

Professor Meijer was appointed as Lecturer in the Department of Microbiology in 1997, University College Dublin. At present he is Associate Professor in the School of Biomolecular and Biomedical Science in UCD. He is a Principal Investigator in the UCD Conway Institute and the Dublin Molecular Medicine Centre. He was appointed to the Special Graduate Faculty of the Department of Pathobiology of the University of Guelph, Canada in 2002.

Professor Meijer is currently member of the Editorial Board of the journal `Antonie van Leeuwenhoek' and was Associate Editor for the journal 'Microbiology' from 2001 to 2005. He was on the organizing committee of the 3rd International Symposium on Rhodococcus equi in the University of Washington 2002 and the 14th International Symposium on the Biology of Actinomycetes 2007 in Newcastle. At present he is an organizer of the 4th International Symposium on Rhodococcus equi to be held in Edinburgh (http://irec.bio.ed.ac.uk/Site/Havemeyer_workshop_08.html )In addition, he served on the Microbiology Committee of the Health Research Board, Enterprise Ireland and the European Union; He reviews papers and grant applications for a large number of journals and funding organizations.

Wim Meijer homepage

Research centre: Infection and Immunity
Research Links: SBBS Research  |  Biotechnology & Synthetic Biology Research in SBBS  |  Infection Biology Research in SBBS  

Macrophage, Pathogen, Infection, Respiratory disease, Fecal contamination, Rhodococcus, Mycobacterium, Microbiology, Genome, Virulence, Conway

Professional

 

Associations

Association: American Society for Microbiology, Function/Role: *

Patents

Patent WO 01/74864 : Protein capable of self-assembly at a hydrophobic-hydrophylic interface and uses thereof(2001)

Disclosures

Rhodococcus equi vaccine. Inventor(s):J.F. Prescott, W.G. Meijer, Y, Pei, J. Ren , Submitted: 08-MAR-05
 

Conference Contributions

Wim G. Meijer; (2008) Organiser and session Co-chair. [Conference Organising Committee Member], Dorothy Havemeyer Foundation Workshop on Rhodococcus equi and Equine Rhodococcal Pneumonia 2008 http://irec.bio.ed.ac.uk/Site/Havemeyer_workshop_08.html, University of Edinburgh, UK , 13-JUL-08 - 16-JUL-08.
Wim G. Meijer; (2002) Chair and Session co-organiser. [Conference Organising Committee Member], Dorothy Havemeyer Foundation Workshop on Rhodococcus equi and Equine Rhodococcal Pneumonia 2002, Washington State University, Pullman USA , 13-JUL-02 - 17-JUL-02.
Wim G. Meijer; (2007) Pathogenic actinomycetes session. [Conference Organising Committee Member], 14th International Symposium on the Biology of Actinomycetes, 2007, Newcastle, UK, Newcastle , 25-AUG-07 - 30-AUG-07.

Committees

Committee : College of Life Science Stokes Committee Infection Biology
Committee : College of Life Science Promotion Committee (2008)
Committee : UCD Science Programme Board
Committee : UCD School of Biomolecular and Biomedical Science, Head of Subject Microbiology
Committee : UCD School of Biomolecular and Biomedical Science, School Executive Committee
Committee : UCD School of Biomolecular and Biomedical Science, Teaching and Learning Committee
Committee : University Undergraduate Programme Board
Committee : UCD School of Biomolecular and Biomedical Science, Chair Microbiology Teaching and Learning Committee
Committee : UCD Seed funding Committee
Committee : UCD Science Steering Committee for development of Science District
Committee : UCD Overhead Investment Plan Advisory Committee (2005/2006)
Committee : QA/QI peer review group member, Department of Medical Microbiology, 2005
Committee : UCD Molecular and Translational Medicine Search Committee 2006-2007

Employment

Employer: National University of Ireland
Position: Senior Lecturer
Employer: Ohio State University
Position: Postdoctoral Research
Employer: University of Groningen
Position: Lecturer
Employer: National University of Ireland
Position: College Lecturer
Employer: University College Dublin
Position: Associate Professor of Microbiology
Employer: University College Dublin
Position: Subject Head Microbiology, UCD School of Biomolecular and Biomedical Science

Education

Year 1986 Institution: University of Groningen
Qualification: MSc Subject:
Year 1990 Institution: University of Groningen
Qualification: PhD Subject:
Year 1983 Institution: University of Groningen
Qualification: BSc Subject:

Languages

French:
Dutch:
English:
German:
     

Other Activities

  • Associate Editor for the journal 'Microbiology' 2001-2005
  • Member of the Editorial Board of the journal 'Antonie van Leeuwenhoek' 2003-present
 

Publications

 

Book Chapters

Prescott, J.F., W.G. Meijer, J.A. Vazquez-Boland; (2010) 'Rhodococcus' In: C.L. Gyles, J.F. Prescott, J.G. Songer, C.O. Thoen (eds). Pathogenesis of bacterial infections of animals. Ames, IA: Wiley-Blackwell Publishing. , pp.149-166 [Details]
Gottschal, J.C. , W.G. Meijer and, Y. Oda.; (1997) 'Use of molecular probing to assess microbial activities in natural ecosystems' In: Eds H. Insam & A. Rangger pp 10-18. Springer, Heidelberg (eds). Microbial communities; functional versus structural approaches. [Details]
Meijer, W. G.; (1996) 'Genetics of CO2 fixation in methylotrophs' In: In M. E. Lidstrom and F. R. Tabita (eds.), Kluwer Academic Publishers, Dordrecht, The Netherlands (eds). Microbial growth on C1 compounds. , pp.118-125 [Details]
Dijkhuizen, L., L. M. Croes, and W. G. Meijer; (1989) 'Mixotrophic growth' In: In G. Hamer, T. Egli, and M. Snozzi (eds.), Hartung﷓Gorre verlag, Konstanz (eds). Mixed and multiple substrates and feedstocks. , pp.21-32 [Details]
 

Peer Reviewed Journals

Bedri, Z; Corkery, A; O'Sullivan, JJ; Deering, LA; Demeter, K; Meijer, WG; O'Hare, G; Masterson, B; (2016) 'Evaluating a microbial water quality prediction model for beach management under the revised EU Bathing Water Directive'. Environmental Management, 167 :49-58. [DOI] [Details]
Foley, C; Chapwanya, A; Callanan, JJ; Whiston, R; Miranda-CasoLuengo, R; Lu, J; Meijer, WG; Cormican, P; Lynn, DJ; O'Farrelly, C; Meade, KG (2015) 'Integrated analysis of the local and systemic changes preceeding the development of post-partum cytological endometritis'. BMC Genomics, 16 :811. Available Online [DOI] [Details]
Coulson, GB; Miranda-CasoLuengo, AA; Miranda-CasoLuengo, R; Wang, X; Oliver, J; Willingham-Lane JM; Meijer, WG; Hondalus, MK (2015) 'Transcriptome reprogramming by plasmid encoded transcriptional regulators is required for host-niche adaptation of a macrophage pathogen'. Infection and Immunity, 83 (8):3137-3145. [Details]
Valero-Rello, A; Hapeshi, A; Anastasi, E; Alvarez, S; Scortti, M; Meijer, WG; MacArthur, I; Vazquez-Boland, J (2015) 'An invertron-like linear plasmid mediates intracellular survival and virulence in bovine isolates of Rhodococcus equi'. Infection and Immunity, 83 (7):2725-2737. [DOI] [Details]
Babatunde, AO; Miranda-CasoLuengo, R; Imtiaz, M; Zhao, YQ; Meijer, WG (2016) 'Performance assessment and microbial diversity of two pilot scale multi-stage sub-surface flow constructed wetland systems'. Journal of Environmental Sciences, 46 :38-46. [DOI] [Details]
Bedri, Z; O'Sullivan, JJ; Deering, LA; Demeter, K; Masterson, B; Meijer, WG; & O'Hare, G.M.P (2015) 'Assessing the water quality response to an alternative sewage disposal strategy at bathing sites on the east coast of Ireland'. Marine Pollution Bulletin, 91 (1):330-346. Available Online [DOI] [Details]
Wang, X; Coulson, GB; Miranda CasoLuengo, AA; Miranda CasoLuengo, R; Hondalus, MK; Meijer, WG (2014) 'IcgA is a virulence factor of Rhodococcus equi modulating intracellular growth'. Infection and Immunity, 82 (5):1793-1800. [DOI] [Details]
Bedri, Z; Corkery, A; O'Sullivan, JJ; Alvarez, MX; Erichsen, AChr, Deering, LA; Demeter, K; O'Hare GMP; Meijer WG; Masterson, B (2014) 'An integrated catchment-coastal modelling system for real-time water quality forecasts'. Environmental Modelling and Software, 61 :458-476. [DOI] [Details]
Whittingham, JL; Blagova, EV; Finn, CE; Luo, H; Miranda-CasoLuengo, R; Turkenburg, JP, Leech, AP; Walton, PH; Murzin, AG; Meijer, WG; Wilkinson, AJ (2014) 'Structure of the virulence-associated protein VapD from the intracellular pathogen Rhodococcus equi'. Acta Crystallographica Section D-Biological Crystallography, 70 :2139-2151. [DOI] [Details]
Sinigalliano, C.D., J. Erven, L.C. van de Werfhorst, B. Badgley, E. Balleste, J. Bartkowiak, A.B. Boehm, M. Byappanahalli, K.D. Goodwin, M. Gourmelon, J. Griffith, P.A. Holden, J. Jay, B. Layton, C. Lee, J. Lee, W.G. Meijer, R. Noble, M. Raith, H. Ryu, M/J. Sadowsky, A. Schriewer, D. Wanless, R. Whitman, S. Wuertz, J.W. Santo Domingo (2013) 'Multi-laboratory evaluations of the performance of Catellicoccus marimammalium PCR assays developed to target gull fecal sources'. Water Research, 47 (18):6883-6896. [DOI] [Details]
Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Lieggi NT, Luo H, Simpson JC, Meijer WG (2013) 'A real-time impedance based method to assess Rhodococcus equi virulence'. PLoS ONE, 8 (3):e60612. Available Online [DOI] [Details]
Maischberger, E; Cummins, CA; Fitzpatrick, E; Gallagher, ME; Worrall, S;Rousseau, K; Thornton, DJ; Meijer, WG; Miranda-CasoLuengo, R; Duggan, VE;Carrington, SD; Irwin, JA; Reid, CJ (2013) ''The expression of mucin genes and the presence of mucin gene products in the equine endometrium''. Research in Veterinary Science, 95 (1):169-175. [DOI] [Details]
Cauchard, S; Giguère, S; Venner, M; Muscatello, G; Cauchard, J; Cohen, ND; Haas, A; Hines, SA; Hondalus, MK; Horohov, DW; Meijer, WG; Prescott, JF; Vázquez-Boland, J (2013) 'Rhodococcus equi research 2008-2012: Report of the Fifth International Havemeyer Workshop'. Equine Veterinary Journal, 45 :523-526. [DOI] [Details]
Liu, L; Tharmalingam, T; Maischberger, E; Miranda-CasoLuengo, R; Meijer, WG; Rudd, PM; Irwin, JA (2013) 'A HPLC-based glycoanalytical protocol allows the use of natural O-glycans derived from glycoproteins as substrates for glycosidase discovery from microbial culture'. Glycoconjugate journal, 30 (8):791-800. [DOI] [Details]
Layton, BA; Cao, Y; Ebentier, DL; Hanley, K; Ballesté, E; Brandão, J; Byappanahalli, M; Converse, R; Farnleitner, AH; Gentry-Shields, J; Gidley, ML; Gourmelon, M; Lee, CS; Lee, J; Lozach, S; Madi, T; Meijer, WG; Noble, R; Peed, L; Reischer, GH; Rodrigues, R; Rose, JB; Schriewer, A; Sinigalliano, C; Srinivasan, S; Stewart, J; Van De Werfhorst, LC; Wang, D; Whitman, R; Wuertz, S; Jay, J; Holden, PA; Boehm, AB; Shanks, O; Griffith, JF (2013) 'Performance of human fecal anaerobe-associated PCR-based assays in a multi-laboratory method evaluation study'. Water Research, 47 (18):6897-6908. [DOI] [Details]
Raith, MR; Kelty, CA; Griffith, JF; Schriewer, A; Wuertz, S; Mieszkin, S; Gourmelon, M; Reischer, GH; Farnleitner, AH; Ervin, JS; Holden, PA; Ebentier, DL; Jay, JA; Wang, D; Boehm, AB; Aw, TG; Rose, JB; Balleste, E; Meijer, WG; Sivaganesan, M; Shanks, O (2013) 'Comparison of PCR and quantitative real-time PCR methods for the characterization of ruminant and cattle fecal pollution sources'. Water Research, 47 (18):6921-6928. [DOI] [Details]
Schriewer, A; Goodwin, KD; Sinigalliano, CD; Cox, A; Wanless, D; Bartkowiak, J; Ebentier, DL; Hanley, KT; Ervin, J; Deering, LA; Shanks, OC; Peed, LA; Meijer, WG; Griffith, JF; SantoDomingo, J; Jay, JA; Holden, PA; Wuertz, S (2013) 'Performance evaluation of canine-associated Bacteroidales assays in a multi-laboratory comparison study'. Water Research, 47 (18):6909-6920. [DOI] [Details]
Garcia MS, Carvalho D, Zlydareva O, Muldoon C, Masterson BF, O'Grady MJ, Meijer,WG, O'Sullivan JJ, O'Hare GMP (2012) 'An agent-based wireless sensor network for water quality data collection'. Lecture Notes in Computer Science, 7656 :454-461. [Details]
Miranda-Casoluengo R, Coulson GB, Miranda-Casoluengo A, Vázquez-Boland JA, Hondalus MK, Meijer WG (2012) 'The hydroxamate siderophore rhequichelin is required for virulence of the pathogenic actinomycete Rhodococcus equi'. Infection and Immunity, 80 (12):4106-4114. Available Online [DOI] [Details]
Miranda-CasoLuengo, R,Miranda-CasoLuengo, AA,O'Connell, EP,Fahey, RJ,Boland, CA,Vazquez-Boland, JA,Meijer, WG; (2011) 'The vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi'. Microbiology-Sgm, 157 :2357-2368. [DOI] [Details]
Higgins, R.M., Danilowicz, B.S., Balbuena, J.A., Danielsdottir, A.K., Geffen, A., Meijer, W.M., Modin, J., Montero, F.E., Pampoulie, C., Perdiguero-Alonso, D., Schreiber, A., Stefansson, M.O. and Wilson, B.; (2010) 'Multi-disciplinary fingerprints reveal the harvest location of cod Gadus morhua in the northeast Atlantic'. Marine Ecology Progress Series, 404 :197-206. [DOI] [Details]
Letek, M; González, P; MacArthur, I; Rodríguez, H; Freeman, TC; Valero-Rello, A; Blanco, M; Buckley, T; Cherevach, I; Fahey, R; Hapeshi, A; Holdstock, J; Leadon, D; Navas, J; Ocampo, A; Quail, MA; Sanders, M; Scortti, MM; Prescott, JF; Fogarty, U; Meijer, WG; Parkhill, J; Bentley, SD; Vázquez-Boland, JA (2010) 'The genome of a pathogenic Rhodococcus: cooptive virulence underpinned by key gene acquisitions'. PLoS Genetics, 6 (9):e1001145. [DOI] [Details]
Dawson, T. R. M. Y., D.W. Horohov, W.G. Meijer, and G. Muscatello.; (2010) 'Current understanding of the equine immune response to Rhodococcus equi: potential impact on immunoprophylaxis'. Veterinary Immunology and Immunopathology, 135 (1-2):1-11. [DOI] [Details]
Smith, C.J., B.S. Danilowicz, W.G. Meijer; (2009) 'Bacteria associated with the mucus layer of Merlangius merlangus (whiting) as biological tags to determine harvest location'. Canadian Journal of Fisheries and Aquatic Science, 66 :713-716. [DOI] [Details]
Vazquez-Boland, J.A., Prescott, J.F., Meijer, W.G, Leadon DP, Hines, S.A.; (2009) 'Rhodococcus equi comes of age'. Equine Veterinary Journal, 41 (1):93-95. [DOI] [Details]
Miranda-CasoLuengo, R., Prescott, J.F., Vazquez-Boland, J.A., Meijer, W.G.; (2008) 'The intracellular pathogen Rhodococcus equi produces a catecholate siderophore required for saprophytic growth'. Journal of Bacteriology, 190 (5):1631-1637. Available Online [DOI] [Details]
Letek, M. Ocampo-Sosa, A., Sanders, M., Fogarty, U., Buckley, T., Leadon, D., Gonzalez, P., Scortii, M., Meijer, W.G., Parkhill, J., Bentley, S., Vazquez-Boland, J.A.; (2008) 'Evolution of the Rhodococcus equi vap pathogenicity island seen through comparison of host associated vapA and vapB virulence plasmids'. Journal of Bacteriology, 190 (17):5797-5805. Available Online [DOI] [Details]
Wilson, B., B.S. Danilowicz and W.G. Meijer; (2008) 'The diversity of bacterial communities associated with Atlantic cod Gadus morhua'. Microbial Ecology, 55 (3):425-434. Available Online [DOI] [Details]
Byrne, G.A., C.A. Boland, E.P. O'Connell and W.G. Meijer; (2008) 'Differential mRNA stability of the vapAICD operon of the facultative intracellular pathogen Rhodococcus equi'. Fems Microbiology Letters, 280 (1):89-94. Available Online [DOI] [Details]
Muscatello, G, D.P. Leadon, A. Ocampo-Sosa, D.A. Lewis, U. Fogarty, T. Buckley, M. Klay, J.R. Gilkerson, W.G. Meijer and J.A. Vazquez-Boland; (2007) 'Rhodococcus equi infection in foals: the science of 'Rattles''. Equine Veterinary Journal, 39 :470-478. [Details]
Smith, C.J., B.S. Danilowicz and W.G. Meijer; (2007) 'Characterisation of the bacterial community associated with the surface and mucus layer of whiting'. Fems Microbiology Ecology, 62 (1):90-97. Available Online [DOI] [Details]
Byrne, G.A., D.A. Russell, X. Chen and W.G. Meijer; (2007) 'Transcriptional regulation of the virR operon of the intracellular pathogen Rhodococcus equi'. Journal of Bacteriology, 189 :5082-5089. Available Online [Details]
Gawler,A.H., Beecher, J.E., Brandão, J., Carroll, N., Falcão, L., Gourmelon, M., Masterson, B., Nunes, B., Porter, J., Rincé, A., Rodrigues, R., Thorp, M., Walters, J.M., and W.G. Meijer ; (2007) 'Validation of host specific Bacteroidetes 16S rRNA genes as markers to determine the origin of faecal pollution in Atlantic Rim countries of the European Union'. Water Research, 41 :3780-3784. [Details]
Pond, K.R., R. Rangdale, W.G. Meijer, J. Brandao, L. Falcao, A. Rince, B. Masterson, J. Greaves, A. Gawler, E. McDonnell, A.A. Cronin, S. Pedley.; (2005) 'Developing pollution source tracking for recreational and shellfish waters'. ENVIRONMENTAL FORENSICS, 5 :237-247. [Details]
Miranda-CasoLuengo, R; Duffy, PS; O'Connell, EP; Graham, BJ; Mangan, MW; Prescott, JF; Meijer, WG; ; (2005) 'The iron-regulated iupABC operon is required for saprophytic growth of the intracellular pathogen Rhodococcus equi at low iron concentrations'. Journal of Bacteriology, 187 (10):3438-3444. [Details]
Smith, CJ; Danilowicz, BS; Clear, AK; Costello, FJ; Wilson, B; Meijer, WG; ; (2005) 'T-Align, a web-based tool for comparison of multiple terminal restriction fragment length polymorphism profiles'. FEMS Micriobiology Ecology, 54 (3):375-380. [Details]
Mangan, MW; Byrne, GA; Meijer, WG; ; (2005) 'Versatile Rhodococcus equi-Escherichia coli shuttle vectors'. Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, 87 (2):161-167. [Details]
Wall, D.M.,Duffy P.S., DuPont C, Prescott J.F., Meijer, W.G.; (2005) 'Isocitrate lyase activity is required for virulence of the intracellular pathogen Rhodococcus equi'. Infection and Immunity, 76 (10):6736-6741. [Details]
Meijer, W.G., Prescott, J.F.; (2004) 'Rhodococcus equi'. Veterinary Research, 35 :383-396. [Details]
Russell, DA; Byrne, GA; O'Connell, EP; Boland, CA; Meijer, WG; ; (2004) 'The LysR-type transcriptional regulator VirR is required for expression of the virulence gene vapA of Rhodococcus equi ATCC 33701'. Journal of Bacteriology, 186 (17):5576-5584. [Details]
Pond, KR; Rangdale, R; Meijer, WG; Brandao, J; Falcao, L; Rince, A; Masterson, B; Greaves, J; Gawler, A; McDonnell, E; Cronin, AA; Pedley, S; ; (2004) 'Workshop report: Developing pollution source tracking for recreational and shellfish waters'. Environmental Forensics, 5 (4):237-247. [Details]
Oda, Y; Meijer, WG; Gibson, JL; Gottschal, JC; Forney, LJ; ; (2004) 'Analysis of diversity among 3-chlorobenzoate-degrading strains of Rhodopseudomonas palustris'. Microbial Ecology, 47 (1):68-79. [Details]
van Keulen, G. and W.G. Meijer.; (2003) 'Improved recovery of DNA from polyacrylamide gels after in situ DNA footprinting'. Journal of Microbiology Methods, 54 :289-291. [Details]
van Keulen, G; Ridder, ANJA; Dijkhuizen, L; Meijer, WG; ; (2003) 'Analysis of DNA binding and transcriptional activation by the LysR-type transcriptional regulator CbbR of Xanthobacter flavus'. Journal of Bacteriology, 185 (4):1245-1252. [Details]
Rahman, MT; Herron, LL; Kapur, V; Meijer, WG; Byrne, BA; Ren, J; Nicholson, VM; Prescott, JE; ; (2003) 'Partial genome sequencing of Rhodococcus equi ATCC 33701'. Veterinary Microbiology, 94 (2):143-158. [Details]
Claessen, D., Wösten, H.A.B., van Keulen, G., Faber, O.G., Alves, A.M.C.R., Meijer, W.G., and Dijkhuizen, L.; (2002) 'Two novel homologous proteins of Streptomyces coelicolor and Streptomyces lividans are involved in formation of the rodlet layer and mediate attachment to a hydrophobic surface'. Molecular Microbiology, 44 :1483-1492. [Details]
Oda, Y; Wanders, W; Huisman, LA; Meijer, WG; Gottschal, JC; Forney, LJ; ; (2002) 'Genotypic and phenotypic diversity within species of purple nonsulfur bacteria isolated from aquatic sediments'. Applied and Environmental Microbiology, 68 (7):3467-3477. [Details]
Kelly, BG; Wall, DM; Boland, CA; Meijer, WG; ; (2002) 'Isocitrate lyase of the facultative intracellular pathogen Rhodococcus equi'. Microbiology-Sgm, 148 (NA):793-798. [Details]
Tichi M.A., W.G. Meijer and F. R. Tabita.; (2001) 'Complex I and its involvement in redox homeostasis and carbon and nitrogen metabolism in Rhodobacter capsulatus'. Journal of Bacteriology, 183 :7285-7294. [Details]
Mangan, MW; Meijer, WG; ; (2001) 'Random insertion mutagenesis of the intracellular pathogen Rhodococcus equi using transposomes'. FEMS Microbiology Letters, 205 (2):243-246. [Details]
van Keulen, G., L. Dijkhuizen, and W. G. Meijer; (2000) 'Effects of the Calvin cycle on the nicotinamide adenine dinucleotide concentrations and redox balances of Xanthobacter flavus'. Journal of Bacteriology, 182 :4637-4639. [Details]
Oda, Y; Slagman, SJ; Meijer, WG; Forney, LJ; Gottschal, JC; ; (2000) 'Influence of growth rate and starvation on fluorescent in situ hybridization of Rhodopseudomonas palustris'. FEMS Micriobiology Ecology, 32 (3):205-213. [Details]
Boland, C. A. and W. G. Meijer; (2000) 'The iron regulatory protein IdeR (DtxR) of Rhodococcus equi'. FEMS Microbiology Letters, 191 :1-5. [Details]
Meijer, W.G., M.E. Nienhuis-Kuiper, and T.A. Hansen; (1999) 'Fermentative bacteria from estuarine mud: Phylogenetic position of Acidaminobacter hydrogenoformans and description of a new type of Gram-negative, propionigenic bacterium as Propionibacter pelophilus gen. nov., sp. nov'. International Journal of Systematic Bacteriology, 49 :1039-1044. [Details]
van Keulen, G., L. Girbal, E.R.E. van den Bergh, L. Dijkhuizen, and W.G. Meijer; (1998) 'The LysR-type transcriptional regulator CbbR controlling autotrophic CO2 fixation is an NADPH-sensor'. Journal of Bacteriology, 180 :1411-1417. [Details]
Shively, JM; van Keulen, G; Meijer, WG; ; (1998) 'Something from almost nothing: Carbon dioxide fixation in chemoautotrophs'. Annual Review of Microbiology, 52 (NA):191-230. [Details]
Meijer, W. G., P. de Boer, and G. van Keulen; (1997) 'Xanthobacter flavus employs a single triosephosphate isomerase for heterotrophic and autotrophic metabolism'. Journal of Microbiology, 143 :1925-1931. [Details]
Meijer, W. G., E. R. E. van den Bergh, and L. M. Smith. .; (1996) 'Induction of the gap-pgk operon encoding glyceraldehyde-3-phosphate dehydrogenase and 3-phosphoglycerate kinase of Xanthobacter flavus requires the LysR-type transcriptional activator CbbR'. Journal of Bacteriology, 178 :881-887. [Details]
Meijer, W. G., van den Bergh, E. R. E. and Smith, L. M. ; (1996) 'The expression of the gap-pgk operon of Xanthobacter flavus is regulated by CbbR, the transcriptional activator of the autotrophic CO2 fixation operon'. Journal of Bacteriology, . Available Online [Details]
Smith, L. M., Meijer, W. G., Dijkhuizen, L. and Goodwin, P. M. ; (1996) 'Smith, L. M., Meijer, W. G., Dijkhuizen, L. and Goodwin, P. M. (1996). A protein having similarity with methylmalonyl CoA mutase is required for the assimilation of methanol and ethanol by Methylobacterium extorquens AM1'. Microbiology, . Available Online [Details]
Alves, A. M. C. R., W. G. Meijer, J. W. Vrijbloed, and L. Dijkhuizen.; (1996) 'Characterization and phylogeny of the pfp gene of Amycolatopsis methanolica encoding pyrophosphate-dependent phosphofructokinase'. Journal of Bacteriology, 178 :149-155. [Details]
van der Maarel, M. J. E. C., M. Jansen, R. Haanstra, W. G. Meijer, and T. A. Hansen.; (1996) 'Demethylation of dimethylsulfoniopropionate to 3-S-methylmercaptopropionate by marine sulfate-reducing and acetogenic bacteria'. Applied Environmental Microbiology, 62 :3978-3984. [Details]
van der Maarel, M. J. E. C., S. van Bergeijk, A. van Werkhoven, A. M. Laverman, W. G. Meijer, W. T. Stam, and T. A. Hansen.; (1996) 'Cleavage of dimethylsulfoniopropionate and reduction of acrylate by Desulfovibrio acrylicus sp. nov. Arch'. Journal of Microbiology, 166 :109-115. [Details]
van den Bergh, E. R. E., S. C. Baker, R. J. Raggers, P. Terpstra, E. C. Woudstra, L. Dijkhuizen, and W. G. Meijer.; (1996) 'Primary structure and phylogeny of the Calvin cycle enzymes transketolase and fructosebisphosphate aldolase of Xanthobacter flavus'. Journal of Bacteriology, 178 :888-893. [Details]
Smith, L. M., W. G. Meijer, L. Dijkhuizen, and P. M. Goodwin.; (1996) 'A protein having similarity with methylmalonyl CoA mutase is required for the assimilation of methanol and ethanol by Methylobacterium extorquens AM1'. Journal of Microbiology, 142 :675-684. [Details]
van den Bergh, E. R. E., T. A. W. van der Kooij, L. Dijkhuizen, and W. G. Meijer.; (1995) 'Fructosebisphosphatase isoenzymes of the chemoautotroph Xanthobacter flavus'. Journal of Bacteriology, 177 :5680-5684. [Details]
Meijer, W. G.; (1994) 'The Calvin cycle enzyme phosphoglycerate kinase of Xanthobacter flavus required for autotrophic CO2 fixation is not encoded by the cbb operon'. Journal of Bacteriology, 176 :6120-6126. [Details]
van den Bergh, E. R. E., L. Dijkhuizen, and W. G. Meijer; (1993) 'CbbR, a LysR type transcriptional activator, is required for expression of the autotrophic CO2 fixation enzymes of Xanthobacter flavus'. Journal of Bacteriology, 175 :6097-6104. [Details]
Meijer, W. G. and F. R. Tabita; (1992) 'Isolation and characterization of the nifUSVW-rpoN gene cluster from Rhodobacter sphaeroides'. Journal of Bacteriology, 174 (12):3855-3866. [Details]
Tabita, F. R., J. L. Gibson, B. Bowien, L. Dijkhuizen, and W. G. Meijer; (1992) 'Uniform designation for the genes of the Calvin Benson Bassham reductive pentose phosphate pathway of bacteria'. FEMS Microbiology Letters, 99 :107-110. [Details]
Croes, L. M., W. G. Meijer, and L. Dijkhuizen; (1991) 'Regulation of methanol oxidation and carbon dioxide fixation in Xanthobacter strain 25a grown in continuous culture'. Archives of Microbiology, 155 :159-163. [Details]
Meijer, W. G., A. C. Arnberg, H. G. Enequist, P. Terpstra, M. E. Lidstrom, and L. Dijkhuizen.; (1991) 'Identification and organization of carbon dioxide fixation genes in Xanthobacter flavus H4-14'. Molecular & General Genetics, 225 (2):320-330. [Details]
Meijer, W. G., H. G. Enequist, P. Terpstra, and L. Dijkhuizen; (1990) 'Nucleotide sequences of the genes encoding fructosebisphosphatase and phosphoribulokinase from Xanthobacter flavus H4-14'. Journal of General Microbilogy, 136 (11):2225-2230. [Details]
Meijer, W. G., L. M. Croes, B. Jenni, L. G. Lehmicke, M. E. Lidstrom, and L. Dijkhuizen; (1990) 'Characterization of Xanthobacter strains H4﷓14 and 25a and enzyme profiles after growth under autotrophic and heterotrophic growth conditions'. Archives of Microbiology, 153 :360-367. [Details]
Eggink, G., H. Engel, W. G. Meijer, J. Otten, J. Kingma, and B. Witholt; (1988) 'Alkane utilization in Pseudomonas oleovorans'. Journal of Biological Chemistry, 263 :13400-13405. [Details]
Meijer, W. G. and L. Dijkhuizen; (1988) 'Regulation of autotrophic metabolism in Pseudomonas oxalaticus OX1 wild-type and an isocitrate lyase deficient mutant'. Journal of General Microbilogy, 134 (12):3231-3237. [Details]
 

Conference Publications

Zlydareva_O.,, Masterson, B.F., Meijer, W.G., J. O¿Sullivanz, J.J., & O¿Hare, G.M.P., (2014) Event-oriented Focal Weight-based Clustering for Environmental Wireless Sensor Networks In Proceedings of 22nd Euromicro International Conference on Parallel, Distributed and Network-Based Processing (PDP 2014) Turin Italy, , 12-FEB-14 - 14-FEB-14 [Details]
Bedri, Z., O'Sullivan, J.J., Corkery, A., Deering, L., Demeter, K., Meijer, W.G., O'Hare, G., & Masterson, B. (2014) Hydro-environmental modelling of sewage and riverine discharges into a coastal area: comparison of depth-averaged and three-dimensional models 3rd IAHR Europe Congress Porto, Portugal, , 14-APR-14 - 16-APR-14 [Details]
Corkery, A., O'Sullivan, J.J., Deering, L., Demeter, K, Balleste, E., Masterson, B., Meijer, W.G. & O'Hare, G. (2014) Modelling quantified source specific microbial pollution from human sources during high flows 3rd IAHR Europe Congress Porto, Portugal, , 14-APR-14 - 16-APR-14 [Details]
Chen, X., Yang, J. & Meijer, W.G.; (2006) Identification of a sensor kinase and arylsulfatase interacting with the orphan response regulator VirS (Orf8) encoded by the virulence plasmid of Rhodococcus equi Society for General Microbiology, Autumn meeting Dublin, Ireland, , 31-AUG-06 [Details]
Lynam, B., Clipson,N., Meijer,W. and J.Gillespie; Denaturing gradient gel electrophoresis profiles compared to 16S rDNA sequence analysis of clones obtained from an enriched and non-enriched bottled natural mineral water Proceedings of the SGM Irish Branch Spring Metting, 'Recent Advances in Molecular Microbial Ecology', UCG.(2000) UCG, [Details]
Ahilan, S., O'Sullivan, J.J., Masterson, B., Demeter, K.,Meijer, W., O'Hare, G. (2013) A threshold based 'discounting' mechanism in the revised EU Bathing Water Directive 33rd Conference on Applied Statistics in Ireland Kildare, Ireland, , 15-MAY-13 - 17-MAY-13 [Details]
O'Sullivan, J.J., Bedri, Z., Corkery, A. , Deering, L. , Demeter, K., Meijer, W.G., Masterson, B. and O'Hare, G. (2013) Bathing water quality prediction using an integrated catchment and 3-D coastal hydrodynamic model International Symposium on Water Resources and Pollution Control in Arid/ Semi-arid Regions (ISWPAR) Xi'an, China, , 21-JUN-13 - 23-JUN-13 , pp.493-500 [Details]
Sanchez, M.; O'Hare, G.M.P.; O'Grady, M.J.; Carvalho, D.; Zlydareva, O.; Muldoon, C.; Meijer, W.; O'Sullivan, J.; O'Keefe, B. (2012) An Agent-based Wireless Sensor Network for Water Quality Data Collection 6th International Conference on Ubiquitous Computing & Ambient Intelligence (UCAmI 2012) Vitoria-Gasteiz, Spain, , pp.454-461 [Details]
Bedri,Z., O'Sullivan, J.J., Corkery, A., Deering, L., Demeter, K., Meijer, W. G., O'Hare, G. and Masterson, B. (2012) Real-time Prediction System of Bathing Water Quality at Bray, Co. Wicklow, Ireland New Developments in IT & Water Amsterdam, , 04-NOV-12 - 06-NOV-12 [Details]
Miranda-CasoLuengo, R and Meijer, WG; (2008) Iron acquisition by Rhodococcus equi 4th Havemeyer Workshop on Rhodococcus equi Edinburgh, UK, [Details]
Miranda-CasoLuengo, R and Meijer, WG; (2008) Rhodococcus equi produces a catecholate siderophore required for saprophytic growth 4th Havemeyer Workshop on Rhodococcus equi Edinburgh, UK, [Details]
Gnojska, A; Fahey, R; Chen, X; Miranda-CasoLuengo, R and Meijer, WG; (2008) Enumeration of proliferating Rhodococcus equi inside macrophage cells 4th Havemeyer Workshop on Rhodococcus equi Edinburgh, UK, [Details]
Finn, C.E., X. Chen & W.G. Meijer; (2007) Protein networks of Rhodococcus equi 160th Meeting of the Society for General Microbiology P MI 34 [Details]
Fahey, R. and W.G. Meijer. 2007; (2007) An investigation into the extent and function of sigma factors in the genome of Rhodococcus equi 160th Meeting of the Society for General Microbiology. P. PS 11 [Details]
Finn, C.E., X. Chen & W.G. Meijer. ; (2007) 160th Meeting of the Society for General Microbiology P MI 34 Protein networks of Rhodococcus equi [Details]
Miranda-CasoLuengo, R. and W.G. Meijer.; (2007) 160th Meeting of the Society for General Microbiology, Manchester. p CCS 09 Iron acquisition by Rhodococcus equi [Details]
Finn, C., X. Chen and W.G Meijer. ; (2007) Virulence protein networks of Rhodococcus equi International Symposium on the Biology of Actinomycetes, University of Newcastle, United Kingdom [Details]
Chen X, Yang J and Meijer W.G. ; (2007) Identification of sensor kinase interacting with VirS encoded by the virulence plasmid of Rhodococcus equi International Symposium on the Biology of Actinomycetes, University of Newcastle, United Kingdom [Details]
Miranda-CasoLuengo, R. and W.G. Meijer; (2007) A novel signal transduction system in mycolic acid-containing bacteria International Symposium on the Biology of Actinomycetes, University of Newcastle, United Kingdom [Details]
Miranda-CasoLuengo, R. & Meijer, W.G.; (2007) Iron Acquisition by Rhodococcus equi 160th Meeting of the Society for General Microbiology,Manchester. p CCS 09 Manchester, UK, , 31-AUG-06 [Details]
                                 

Reviews

Dawson, TRMY,Horohov, DW,Meijer, WG,Muscatello, G (2010) Current understanding of the equine immune response to Rhodococcus equi. An immunological review of R. equi pneumonia. Reviews [DOI] [Details]
             

Technical Publication

Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Lieggi NT, Luo H, Simpson JC and Meijer WG (2013) Analysis of macrophage morphology changes following R. equi infection. Technical Publication [Details]
                                                             

Research

Research Interests

Research in my group focuses on the facultative intracellular pathogen Rhodococcus equi, a bacterium that has many physiological and pathological similarities to the related pathogen Mycobacterium tuberculosis. R. equi is an important pathogen of young foals and an opportunistic human pathogen that prevents phagosomal maturation of macrophages, its preferred host cell. Virulence is dependent on a 81 kb virulence plasmid, which contains a 27 kb pathogenicity island. Although it has been shown that genes located in this island are essential for virulence, the function of the proteins they encode remains largely unknown. Research in my group concentrates on three main areas (please refer to the Molecular Microbiology web page for details (http://www.ucd.ie/molmicro/)

Identification and characterisation of metabolic pathways (in particular of carbon and iron uptake) that are required for intracellular proliferation of R. equi.


Functional analysis of virulence proteins encoded on the virulence plasmid of R. equi and their effect on host cell physiology.


Analysis of the regulatory mechanisms controlling gene expression, in particular of virulence genes.


We also participate in a project to determine the complete genome sequence of R. equi in collaboration with the Sanger Centre (www.sanger.ac.uk/Projects/R_equi).


Microbial Source Tracking

We currently participate in two large multinational projects funded by the European Union focusing on Microbial Source Tracking. CODTRACE uses microbial populations as marker for the origin of harvest of Cod, whereas ICReW aims to determine the origin of faecal contamination. Details of these projects can be found on the project web pages www.icrew.info and www.codtrace.ie.

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