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Ioscani Jimenez Del Val

Lecturer/Assistant Professor

School Of Chem & Bioprocess Engineering
Engineering Building
Belfield
Dublin 4

Tel: +353 1 7161923
Email: ioscani.jimenezdelval@ucd.ie

Biography

Ioscani graduated with a BE in Chemical Engineering from the National Autonomous University of Mexico (UNAM) in 2006. After a year as Project Engineer at the Mario Molina Centre on Energy & Environment in Mexico City, Ioscani moved to the UK to pursue graduate studies. He received his MSc in Advanced Chemical Engineering with Biotechnology in 2008 and was awarded his PhD in 2013, both from Imperial College London. His PhD research involved developing an integrated modelling and experimental framework to quantitatively relate bioprocess conditions with monoclonal antibody glycosylation.

After obtaining his PhD, Ioscani spent 2 years as a Postdoctoral Research Associate at Imperial College working with Dr. Cleo Kontoravdi and Dr. Karen Polizzi on modelling nucleotide sugar metabolism and developing analytical methods to measure the intracellular concentration of these metabolites. Ioscani joined the UCD School of Chemical & Bioprocess Engineering in 2014 where he will continue work on bioprocess modelling and optimisation with particular emphasis on therapeutic protein quality.

Professional

Honours and Awards

Year: 2013.
Title: Dudley Newitt Prize for Computational/Theoretical Excellence

Associations

Association: Institution of Chemical Engineers, Function/Role: Associate Member
Association: Engineers Ireland, Function/Role: MIEI
         

Employment

Employer: Mario Molina Centre for Strategic Studies on Energy & Environment
Position: Project Engineer
Employer: Imperial College London
Position: Postdoctoral Research Associate

Education

Year 2008 Institution: Imperial College, London, UK
Qualification: MSc Subject:
Year 2013 Institution: Imperial College, London, UK
Qualification: PhD Subject:
Year 2006 Institution: Universidad Nacional Autonoma de Mexico (UNAM)
Qualification: BSc Subject:

Languages

Spanish:
       

Publications

 

Book Chapters

Ioscani Jimenez del Val, Philip M Jedrzejewski, Kealan Exley, Si Nga Sou, Sarantos Kyriakopoulos, Karen M Polizzi, Cleo Kontoravdi (2012) 'Application of Quality by Design Paradigm to the Manufacture of Protein Therapeutics' In: Stefana Petrescu (eds). Glycosylation. Croatia: InTech. Available Online [DOI] [Details]
 

Peer Reviewed Journals

Ioscani Jimenez del Val, Karen M Polizzi and Cleo Kontoravdi (2016) 'A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation'. Scientific Reports, 6 :28547. Available Online [DOI] [Details]
Ioscani Jimenez del Val, Yuzhou Fan, Dietmar Weilguny (2016) 'Dynamics of immature mAb glycoform secretion during CHO cell culture: An integrated modelling framework'. Biotechnology journal, 11 (5):610-623. Available Online [DOI] [Details]
Yuzhou Fan, Ioscani Jimenez del Val, Christian Müller, Anne Mathilde Lund, Jette Wagtberg Sen, Søren Kofoed Rasmussen, Cleo Kontoravdi, Deniz Baycin‐Hizal, Michael J Betenbaugh, Dietmar Weilguny, Mikael Rørdam Andersen (2015) 'A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture'. Biotechnology and Bioengineering, 112 (10):2172-2184. [Details]
Yuzhou Fan, Ioscani Jimenez del Val, Christian Müller, Jette Wagtberg Sen, Søren Kofoed Rasmussen, Cleo Kontoravdi, Dietmar Weilguny, Mikael Rørdam Andersen (2015) 'Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation'. Biotechnology and Bioengineering, 112 (3):521-535. Available Online [DOI] [Details]
Efti Todri, Andrew N Amenaghawon, Ioscani Jimenez del Val, David J Leak, Cleo Kontoravdi, Sergei Kucherenko, Nilay Shah (2014) 'Global sensitivity analysis and meta-modeling of an ethanol production process'. Chemical Engineering Science, 114 :114-127. Available Online [DOI] [Details]
Philip M Jedrzejewski, Ioscani Jimenez del Val, Antony Constantinou, Anne Dell, Stuart M Haslam, Karen M Polizzi, Cleo Kontoravdi (2014) 'Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation'. International journal of molecular sciences, 15 (3):4492-4522. Available Online [Details]
Jedrzejewski, PM, del Val, IJ, Polizzi, KM, Kontoravdi, C (2013) 'Applying quality by design to glycoprotein therapeutics: experimental and computational efforts of process control'. Pharmaceutical Bioprocessing, 1 (1):51-69. Available Online [Details]
Ioscani Jimenez del Val, Sarantos Kyriakopoulos, Karen M Polizzi, Cleo Kontoravdi (2013) 'An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells'. Analytical Biochemistry, 443 (2):172-180. Available Online [DOI] [Details]
Kate E Royle, Ioscani Jimenez del Val, Cleo Kontoravdi (2013) 'Integration of models and experimentation to optimise the production of potential biotherapeutics'. Drug Discovery Today, 18 (23-24):1250-1255. Available Online [DOI] [Details]
Ning Chen, Ioscani Jimenez del Val, Sarantos Kyriakopoulos, Karen M Polizzi, Cleo Kontoravdi (2012) 'Metabolic network reconstruction: advances in in silico interpretation of analytical information'. Current opinion in biotechnology, 23 (1):77-82. Available Online [DOI] [Details]
Ioscani Jimenez del Val, Judit M Nagy, Cleo Kontoravdi (2011) 'A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus'. Biotechnology Progress, 27 (6):1730-1743. Available Online [Details]
Ioscani Jimenez del Val, Cleo Kontoravdi, Judit M Nagy (2010) 'Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns'. Biotechnology Progress, 26 (6):1505-1527. Available Online [Details]
Aída Gutiérrez-Alejandre, Jorge Ramírez, Ioscani Jiménez-del Val, Mauricio Peñuelas-Galaz, Pedro Sánchez-Neri, Pablo Torres-Mancera (2005) 'Activity of NiW catalysts supported on TiO2-Al2O3 mixed oxides: Effect of Ti incorporation method on the HDS of 4,6-DMDBT'. Catalysis Today, 107-108 :879-884. Available Online [DOI] [Details]
 

Conference Publications

Ioscani Jiménez del Val, Antony Constantinou, Anne Dell, Stuart Haslam, Karen M Polizzi, Cleo Kontoravdi (2013) A quantitative and mechanistic model for monoclonal antibody glycosylation as a function of nutrient availability during cell culture 23rd ESACT Meeting Available Online [DOI] [Details]
Ioscani Jiménez del Val, Judit M Nagy, Cleo Kontoravdi (2011) Quantification of intracellular nucleotide sugars and formulation of a mathematical model for prediction of their metabolism 22nd ESACT Meeting Available Online [DOI] [Details]
                                                                                                                 

Research

Research Interests

My current work combines experimental and computational methods to describe, control and optimise pharmaceutical bioprocesses. My specific fields of interest are:

  • Therapeutic protein N- and O-linked glycosylation
  • Genetic regulatory circuits
  • Mammalian cell glycoproteomics
  • Pharmaceutical bioprocess modelling & control

Research Projects

Sponsor : Irish Research Council (IRC)
Title : Investigating the dynamics of CHO cell surface glycosylation as a robust predictor of therapeutic protein glycoform distribution
Start Date / End Date : 01-OCT-15 / 30-SEP-19
   

Collaborators

Internal Collaborators

Prof Brian Glennon, UCD School of Chemical & Bioprocess Engineering
Dr Susan McDonnell, UCD School of Chemical & Bioprocess Engineering

External Collaborators

Dr Cleo Kontoravdi, Department of Chemical Engineering, Imperial College London
Dr Karen Polizzi, Centre for Synthetic Biology & Innovation, Imperial College London
Prof Nicole Borth, Institute of Biotechnology, University of Natural Resources & Life Sciences, Vienna
Dr Alexandros Kiparissides,  Department of Biochemical Engineering, University College London
Dr Jonathan Bones, National Institute for Bioprocessing Research & Training