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Researchers at UCD

researcher

Niall Barron

Professor of Biochemical Engineering

School Of Chem & Bioprocess Engineering
Engineering Building
Belfield
Dublin 4

Tel: +353 1 7161895
Email: niall.barron@ucd.ie

Biography

Niall Barron obtained a BA(Mod) in Microbiology from Trinity College Dublin and PhD in Applied Microbiology/Biochemistry from the University of Ulster in 1997. He spent three years at Baylor College of Medicine in Dr.Bert O¿Malley¿s lab as a postdoctoral scientist working on genome engineering strategies to study nuclear steroid receptor function. He then returned to Ireland to work with Prof.Martin Clynes on stem cell engineering at the National Cell and Tissue Culture Centre in DCU. Subsequently, as a senior scientist in the National Institute for Cellular Biotechnology (NICB), he was instrumental in growing the mammalian cell engineering group with a specific focus on the production of recombinant therapeutic proteins. He was Director of NICB from 2015 until 2017 and was a member of academic staff in the School of Biotechnology in DCU.
He was appointed Professor of Biochemical Engineering in the School of Chemical and Bioprocess Engineering in UCD and NIBRT Principal Investigator in 2017.

Professional

 

Associations

Association: European Society for Animal Cell Technology (ESACT), Function/Role: Treasurer and Executive Committee Member

Patents

Patent US8476244 : A method for producing recombinant proteins
Patent EP2046970 : A method of producing recombinant biological products
   

Conference Contributions

Barron, N., Brady, D., Love, G., Marchant, R. Nigam, P., McHale, L. & McHale, A.P. ; Alginate immobilised thermotolerant yeast for conversion of cellulose to ethanol. [N/A], In Symposium proceedings; Progress in Biotechnology Volume 11 Immobilised cells: Basics and Applications Elsevier Science B.V. 1996, * .
Koob, S., Barron, N., Chou, J. H., Sinacore, M. (2007) Development of a high throughput purification method for analysis of cell culture samples. [Poster Presentation], 234th ACS National Meeting, Boston , 19-AUG-07 - 23-AUG-07.
 

Employment

Employer: Dublin City University
Position: Director of the National Institute for Cellular Biotechnology
Employer: Dublin City University
Position: Lecturer/Senior Lecturer
Employer: Dublin City University
Position: Program Leader
Employer: Dublin City University
Position: Research Scientist
Employer: Baylor College of Medecine
Position: Postdoc

Education

Year 1997 Institution: University of Ulster
Qualification: DPhil Subject:
Year 1992 Institution: Trinity College Dublin
Qualification: BA (Mod) Subject: Microbiology
 

Consultancy

Client: Epirus Biopharmaceuticals
 

Journals Edited

Biotechnology Letters: Editor.
 

Publications

 

Book Chapters

Clarke C, Barron N, Gallagher M, Henry M, Meleady P, Clynes M. (2012) 'Target Prediction Algorithms and Bioinformatics Resources for miRNA Studies' In: Barron, N (eds). MicroRNAs as Tools in Biopharmaceutical Production. Netherlands: Springer. , pp.29-48 [DOI] [Details]
Mehta J.P, O'Driscoll L., Barron N. Clynes M. (2010) 'Translating in vitro cell lines results into clinical practice' In: Mehta J.P, O'Driscoll L., Barron N. Clynes M (eds). Methods of Cancer Diagnosis, therapy and prognosis Vol 7. USA: Springer. [Details]
Mehta, J. P., O'Driscoll, L., Barron, N., Clynes, M., Doolan, P. (2010) 'Translating In Vitro Cell Lines Result into Clinical Practice' In: Hayat, MA (eds). Methods of Cancer Diagnosis, Therapy, and Prognosis, Vol 7. Netherlands: Springer. , pp.183-191 Available Online [Details]
Barron, N., Brady, D., Love, G., Marchant, R., Nigam, P., McHale, L., McHale, A. P. (1996) 'Alginate-immobilized thermotolerant yeast for conversion of cellulose to ethanol' In: R.H.Wijffels, R.M.Buitelaar, C.Bucke, J.Tramper (eds). Immobilized Cells: Basics and Applications. Netherlands: Elsevier. , pp.379-383 Available Online [Details]

Edited Books

Barron, N (Ed.). (2012) MicroRNAs as Tools in Biopharmaceutical Production. Netherlands: Springer. [Details]
Jenkins N, Barron N, Alves P (Ed.). (2012) Proceedings of the 21st Meeting of the European Society for Animal Cell Technology 2009. Netherlands: Springer. [Details]

Peer Reviewed Journals

Costello, A., Lao, N., Clynes, M., Barron, N. (2017) 'Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors'. Methods Mol Biol, 1603 :87-100. Available Online [Details]
Suda, S., Field, D., Barron, N. (2017) 'Antimicrobial Peptide Production and Purification'. Methods Mol Biol, 1485 :401-410. Available Online [Details]
Monger, C., Motheramgari, K., McSharry, J., Barron, N., Clarke, C. (2017) 'A Bioinformatics Pipeline for the Identification of CHO Cell Differential Gene Expression from RNA-Seq Data'. Methods Mol Biol, 1603 :169-186. Available Online [Details]
Levingstone, T. J., Barron, N., Ardhaoui, M., Benyounis, K., Looney, L., Stokes, J. (2017) 'Application of response surface methodology in the design of functionally graded plasma sprayed hydroxyapatite coatings'. Surface & Coatings Technology, 313 :307-318. Available Online [Details]
Kelly, P. S., Clarke, C., Costello, A., Monger, C., Meiller, J., Dhiman, H., Borth, N., Betenbaugh, M. J., Clynes, M., Barron, N. (2017) 'Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells'. Metab Eng, 41 :11-22. Available Online [Details]
Kelly, P. S., McSweeney, S., Coleman, O., Carillo, S., Henry, M., Chandran, D., Kellett, A., Bones, J., Clynes, M., Meleady, P., Barron, N. (2016) 'Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics'. Biotechnol Prog, 32 (6):1547-1558. Available Online [Details]
Terzidis, M. A., Prisecaru, A., Molphy, Z., Barron, N., Randazzo, A., Dumont, E., Krokidis, M. G., Kellett, A., Chatgilialoglu, C. (2016) 'Radical-induced purine lesion formation is dependent on DNA helical topology'. Free Radic Res, 50 (sup1). Available Online [Details]
Slator, C., Barron, N., Howe, O., Kelleet, A. (2016) '[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction'. Acs Chemical Biology, 11 (1):159-171. Available Online [Details]
Kelly, P. S., Breen, L., Gallagher, C., Kelly, S., Henry, M., Lao, N. T., Meleady, P., O'Gorman, D., Clynes, M., Barron, N. (2015) 'Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype'. Biotechnol J, 10 (7):1029-40. Available Online [Details]
Monger, C., Kelly, P. S., Gallagher, C., Clynes, M., Barron, N., Clarke, C. (2015) 'Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling'. Biotechnol J, 10 (7):950-66. Available Online [Details]
Kelly, P. S., Gallagher, C., Clynes, M., Barron, N. (2015) 'Conserved microRNA function as a basis for Chinese hamster ovary cell engineering'. Biotechnol Lett, 37 (4):787-98. Available Online [Details]
Molphy, Z., Prisecaru, A., Slator, C., Barron, N., McCann, M., Colleran, J., Chandran, D., Gathergood, N., Kellett, A. (2014) 'Copper phenanthrene oxidative chemical nucleases'. Inorg Chem, 53 (10):5392-404. Available Online [Details]
Sanchez, N., Kelly, P., Gallagher, C., Lao, N. T., Clarke, C., Clynes, M., Barron, N. (2014) 'CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors'. Biotechnol J, 9 (3):396-404. Available Online [Details]
Doolan, P., Clarke, C., Kinsella, P., Breen, L., Meleady, P., Leonard, M., Zhang, L., Clynes, M., Aherne, S. T., Barron, N. (2013) 'Transcriptomic analysis of clonal growth rate variation during CHO cell line development'. J Biotechnol, 166 (3):105-13. Available Online [Details]
Sanchez, N., Gallagher, M., Lao, N., Gallagher, C., Clarke, C., Doolan, P., Aherne, S., Blanco, A., Meleady, P., Clynes, M., Barron, N. (2013) 'MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3'. PLoS One, 8 (6). Available Online [Details]
Prisecaru, A., McKee, V., Howe, O., Rochford, G., McCann, M., Colleran, J., Pour, M., Barron, N., Gathergood, N., Kellett, A. (2013) 'Regulating bioactivity of Cu2+ bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates'. J Med Chem, 56 (21):8599-615. Available Online [Details]
McCann, M., McGinley, J., Ni, K., O'Connor, M., Kavanagh, K., McKee, V., Colleran, J., Devereux, M., Gathergood, N., Barron, N., Prisecaru, A., Kellett, A. (2013) 'A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction'. Chem Commun (Camb), 49 (23):2341-3. Available Online [Details]
Jadhav, V., Hackl, M., Druz, A., Shridhar, S., Chung, C. Y., Heffner, K. M., Kreil, D. P., Betenbaugh, M., Shiloach, J., Barron, N., Grillari, J., Borth, N. (2013) 'CHO microRNA engineering is growing up: recent successes and future challenges'. Biotechnol Adv, 31 (8):1501-13. Available Online [Details]
Barron, N., Keenan, J., Gammell, P., Martinez, V. G., Freeman, A., Masters, J. R., Clynes, M. (2012) 'Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer'. Prostate, 72 (11):1193-9. Available Online [Details]
Prisecaru, A., Devereux, M., Barron, N., McCann, M., Colleran, J., Casey, A., McKeee, V., Kellett, A. (2012) 'Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu-2(mu-terephthalate)(1,10-phen)(4)](2+)'. Chemical Communications, 48 (55):6906-6908. Available Online [Details]
Patil, A. J., Kumar, R. K., Barron, N. J., Mann, S. (2012) 'Cerium oxide nanoparticle-mediated self-assembly of hybrid supramolecular hydrogels'. Chemical Communications, 48 (64):7934-7936. Available Online [Details]
Meleady, P., Hoffrogge, R., Henry, M., Rupp, O., Bort, J. H., Clarke, C., Brinkrolf, K., Kelly, S., Muller, B., Doolan, P., Hackl, M., Beckmann, T. F., Noll, T., Grillari, J., Barron, N., Puhler, A., Clynes, M., Borth, N. (2012) 'Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics'. Biotechnol Bioeng, 109 (6):1386-94. Available Online [Details]
Meleady, P., Gallagher, M., Clarke, C., Henry, M., Sanchez, N., Barron, N., Clynes, M. (2012) 'Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells'. J Biotechnol, 160 (3-4):251-62. Available Online [Details]
Howe, K., Eustace, A. J., Souahli, S., Browne, B. C., Aherne, S., Barron, N., Walsh, N., Crown, J., O'Donovan, N. (2012) 'MicroRNA-224 and-375 in Trastuzumab and Lapatinib Acquired and Innate Resistant HER2 Positive Breast Cancer Cells'. European Journal of Cancer, 48 :44-44. Available Online [Details]
Howe, K., Eustace, A., Souahli, S., Browne, B. C., Aherne, S., Barron, N., Walsh, N., Crown, J. P., O'Donovan, N. (2012) 'Microrna-9 and-224 in Trastuzumab Resistant Her2 Positive Breast Cancer Cells'. Annals of Oncology, 23 :528-528. Available Online [Details]
Doolan, P., Barron, N., Kinsella, P., Clarke, C., Meleady, P., O'Sullivan, F., Melville, M., Leonard, M., Clynes, M. (2012) 'Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines'. Biotechnol J, 7 (4):516-26. Available Online [Details]
Clarke, C., Henry, M., Doolan, P., Kelly, S., Aherne, S., Sanchez, N., Kelly, P., Kinsella, P., Breen, L., Madden, S. F., Zhang, L., Leonard, M., Clynes, M., Meleady, P., Barron, N. (2012) 'Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate'. BMC Genomics, 13 :656. Available Online [Details]
Clarke, C., Doolan, P., Barron, N., Meleady, P., Madden, S. F., DiNino, D., Leonard, M., Clynes, M. (2012) 'CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture'. Biotechnol Bioeng, 109 (6):1368-70. Available Online [Details]
Barron, N., Kumar, N., Sanchez, N., Doolan, P., Clarke, C., Meleady, P., O'Sullivan, F., Clynes, M. (2011) 'Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7'. J Biotechnol, 151 (2):204-11. Available Online [Details]
Sanchez, N., Lao, N., Gallagher, C., Clynes, M., Barron, N. (2011) 'Engineering CHO cell growth by stable manipulation of miRNA expression'. BMC Proceedings, 5 Suppl 8 . Available Online [Details]
Piskareva, O., Lackington, W., Lemass, D., Hendrick, C., Doolan, P., Barron, N. (2011) 'The human L1 element: a potential biomarker in cancer prognosis, current status and future directions'. Curr Mol Med, 11 (4):286-303. Available Online [Details]
Melville, M., Doolan, P., Mounts, W., Barron, N., Hann, L., Leonard, M., Clynes, M., Charlebois, T. (2011) 'Development and characterization of a Chinese hamster ovary cell-specific oligonucleotide microarray'. Biotechnol Lett, 33 (9):1773-9. Available Online [Details]
Meleady, P., Doolan, P., Henry, M., Barron, N., Keenan, J., O'Sullivan, F., Clarke, C., Gammell, P., Melville, M. W., Leonard, M., Clynes, M. (2011) 'Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype'. BMC Biotechnol, 11 :78. Available Online [Details]
Clarke, C., Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M., Clynes, M. (2011) 'Predicting cell-specific productivity from CHO gene expression'. J Biotechnol, 151 (2):159-65. Available Online [Details]
Clarke, C., Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M., Clynes, M. (2011) 'Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity'. J Biotechnol, 155 (3):350-9. Available Online [Details]
Barron, N., Sanchez, N., Kelly, P., Clynes, M. (2011) 'MicroRNAs: tiny targets for engineering CHO cell phenotypes?'. Biotechnol Lett, 33 (1):11-21. Available Online [Details]
Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ; (2010) 'Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle'. Journal of Physiology, 588 (Pt 10):1779-1790. [DOI] [Details]
Rani, S., Mehta, J. P., Barron, N., Doolan, P., Jeppesen, P. B., Clynes, M., O'Driscoll, L. (2010) 'Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion'. Cell Physiol Biochem, 25 (6):667-74. Available Online [Details]
Rani, S., Mehta, J. P., Barron, N., Doolan, P., Clynes, M., Jeppesen, P. B., O'Driscoll, L. (2010) 'Txnip-Identified as a Regulator of Glucose-Stimulated Insulin Secretion and Reactive Oxygen Species in Min6 Cells'. Irish Journal of Medical Science, 179 . Available Online [Details]
Melville, M., Sinacore, M. S., Di Nino, D., McCarthy, K., Anderson, K., Kopycinski, K., Lee, G. W., Max, S., Gammell, P., Doolan, P., Meleady, P., Barron, N., Leonard, M., Clynes, M., Charlebois, T. (2010) 'Differential Expression Profiling of Industrially Relevant CHO Cell Phenotypes Using a Proprietary CHO-Specific Microarray and Proteomics Technology Platforms'. Cells and Culture, 4 :421-423. Available Online [Details]
Gandhiraman, R. P., Muniyappa, M. K., Dudek, M., Coyle, C., Volcke, C., Killard, A. J., Burham, P., Daniels, S., Barron, N., Clynes, M., Cameron, D. C. (2010) 'Interaction of Plasma Deposited HMDSO-Based Coatings with Fibrinogen and Human Blood Plasma: The Correlation between Bulk Plasma, Surface Characteristics and Biomolecule Interaction'. Plasma Processes and Polymers, 7 (5):411-421. Available Online [Details]
Egan, B., Carson, B. P., Garcia-Roves, P. M., Chibalin, A. V., Sarsfield, F. M., Barron, N., McCaffrey, N., Moyna, N. M., Zierath, J. R., O'Gorman, D. J. (2010) 'Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor. coactivator-1 alpha mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle'. Journal of Physiology-London, 588 (10):1779-1790. Available Online [Details]
Doolan, P., Meleady, P., Barron, N., Henry, M., Gallagher, R., Gammell, P., Melville, M., Sinacore, M., McCarthy, K., Leonard, M., Charlebois, T., Clynes, M. (2010) 'Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines'. Biotechnol Bioeng, 106 (1):42-56. Available Online [Details]
Rani, S,Mehta, JP,Barron, N,Doolan, P,Jeppesen, PB,Clynes, M,O'Driscoll, L; (2010) 'Decreasing Txnip mRNA and Protein Levels in Pancreatic MIN6 Cells Reduces Reactive Oxygen Species and Restores Glucose Regulated Insulin Secretion'. Cellular Physiology and Biochemistry, 25 :667-674. [DOI] [Details]
Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ; (2010) 'Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1alpha mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle'. Journal of Physiology, 588 (10):1779-1790. [DOI] [Details]
Rani S, Mehta JP, Barron N, Doolan P, Jeppesen PB, Clynes M, O'Driscoll L (2010) 'Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion'. Cellular Physiology and Biochemistry, 25 (6):667-674. [DOI] [Details]
Muniyappa, M. K., Dowling, P., Henry, M., Meleady, P., Doolan, P., Gammell, P., Clynes, M., Barron, N. (2009) 'MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines'. Eur J Cancer, 45 (17):3104-18. Available Online [Details]
Pierce, A., Barron, N., Linehan, R., Ryan, E., O'Driscoll, L., Daly, C., Clynes, M. (2008) 'Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines'. Eur J Cancer, 44 (1):151-9. Available Online [Details]
McKiernan E, O'Driscoll L, Kasper M, Barron N, O'Sullivan F, Clynes M (2007) 'Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes'. Tissue Engineering, 13 (10):2419-2430. [DOI] [Details]
Piskareva, O., Clynes, M., Barron, N. (2007) 'Detection and cloning of LINE-1 elements in CHO cells'. Cytotechnology, 53 (1-3):75-80. Available Online [Details]
Mehta, J. P., O'Driscoll, L., Barron, N., Clynes, M., Doolan, P. (2007) 'A microarray approach to translational medicine in breast cancer: how representative are cell line models of clinical conditions?'. Anticancer Res, 27 (3A):1295-300. Available Online [Details]
McKiernan, E., O'Driscoll, L., Kasper, M., Barron, N., O'Sullivan, F., Clynes, M. (2007) 'Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes'. Tissue Eng, 13 (10):2419-30. Available Online [Details]
Mc Kiernan, E., Barron, N. W., O'Sullivan, F., Barham, P., Clynes, M., O'Driscoll, L. (2007) 'Detecting de novo insulin synthesis in embryonic stem cell-derived populations'. Exp Cell Res, 313 (7):1405-14. Available Online [Details]
Gammell, P., Barron, N., Kumar, N., Clynes, M. (2007) 'Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells'. J Biotechnol, 130 (3):213-8. Available Online [Details]
Barron, N., Piskareva, O., Muniyappa, M. (2007) 'Targeted genetic modification of cell lines for recombinant protein production'. Cytotechnology, 53 (1-3):65-73. Available Online [Details]
Mehta JP, O'Driscoll L, Barron N, Clynes M, Doolan P (2007) 'A microarray approach to translational medicine in breast cancer: how representative are cell line models of clinical conditions?'. Anticancer Research, 27 (3A):1295-1300. [Details]
Piskareva, O. A., Barron, N., Clynes, M., Shmatchenko, V. V. (2004) 'In vivo cytoplasmic localization of the p40 protein of the L1 transposable element of human genome'. Dokl Biochem Biophys, 395 :118-9. Available Online [Details]
Lanz, R. B., Chua, S. S., Barron, N., Soder, B. M., DeMayo, F., O'Malley, B. W. (2003) 'Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo'. Mol Cell Biol, 23 (20):7163-76. Available Online [Details]
New, M. I., Nimkarn, S., Brandon, D. D., Cunningham-Rundles, S., Wilson, R. C., Newfield, R. S., Vandermeulen, J., Barron, N., Russo, C., Loriaux, D. L., O'Malley, B. (2001) 'Resistance to multiple steroids in two sisters'. J Steroid Biochem Mol Biol, 76 (1-5):161-6. Available Online [Details]
New, M. I., Nimkarn, S., Brandon, D. D., Cunningham-Rundles, S., Wilson, R. C., Newfield, R. S., Vandermeulen, J., Barron, N., Russo, C., Loriaux, D. L., O'Malley, B. (1999) 'Resistance to several steroids in two sisters'. J Clin Endocrinol Metab, 84 (12):4454-64. Available Online [Details]
Ferguson, P., Mulholland, H., Barron, N., Brady, D., McHale, A. P. (1998) 'Sucrose-supplemented distillery spent wash as a medium for production of ethanol at 45 degrees C by free and alginate-immobilized preparations of Kluyveromyces marxianus IMB3'. Bioprocess Engineering, 18 (4):257-259. Available Online [Details]
Love, G., Gough, S., Brady, D., Barron, N., Nigam, P., Singh, D., Marchant, R., McHale, A. P. (1998) 'Continuous ethanol fermentation at 45 degrees C using Kluyveromyces marxianus IMB3 immobilized in Calcium alginate and kissiris'. Bioprocess Engineering, 18 (3):187-189. Available Online [Details]
Gough, S., Barron, N., Zubov, A. L., Lozinsky, V. I., McHale, A. P. (1998) 'Production of ethanol from molasses at 45 degrees C using Kluyveromyces marxianus IMB3 immobilized in calcium alginate gels and poly(vinyl alcohol) cryogel'. Bioprocess Engineering, 19 (2):87-90. Available Online [Details]
Barron, N., Mulholland, H., Boyle, M., McHale, A. P. (1997) 'Ethanol production by Kluyveromyces marxianus IMB3 during growth on straw-supplemented whiskey distillery spent wash at 45 degrees C'. Bioprocess Engineering, 17 (6):383-386. Available Online [Details]
Boyle, M., Barron, N., McHale, A. P. (1997) 'Simultaneous saccharification and fermentation of straw to ethanol using the thermotolerant yeast strain Kluyveromyces marxianus imb3'. Biotechnology Letters, 19 (1):49-51. Available Online [Details]
Barron, N., Marchant, R., McHale, L., McHale, A. P. (1996) 'Short communication: Ethanol production from cellulose at 45 degrees C using a batch-fed system containing alginate-immobilized Kluyveromyces marxianus IMB3'. World J Microbiol Biotechnol, 12 (1):103-4. Available Online [Details]
Winters, A., Gallagher, J., Barron, N., Rollan, A., McHale, A. P. (1996) 'Molecular cloning and expression of a Micromonospora chalcae beta-glucosidase encoding gene in Escherichia coli'. Biotechnology Letters, 18 (12):1387-1390. Available Online [Details]
Riordan, C., Love, G., Barron, N., Nigam, P., Marchant, R., McHale, L., McHale, A. P. (1996) 'Production of ethanol from sucrose at 45 degrees C by alginate-immobilized preparations of the thermotolerant yeast strain Kluyveromyces marxianus IMB3'. Bioresource Technology, 55 (2):171-173. Available Online [Details]
Love, G., Nigam, P., Barron, N., Singh, D., Marchant, R., McHale, A. P. (1996) 'Ethanol production at 45 degrees C using preparations of Kluyveromyces marxianus IMB3 immobilized in calcium alginate and kissiris'. Bioprocess Engineering, 15 (5):275-277. Available Online [Details]
Gallagher, J., Winters, A., Barron, N., McHale, L., McHale, A. P. (1996) 'Production of cellulase and beta-glucosidase activity during growth of the actinomycete Micromonospora chalcae on cellulose-containing media'. Biotechnology Letters, 18 (5):537-540. Available Online [Details]
Barron, N., Rollan, A., Marchant, R., Higgins, D., McHale, A. P. (1996) 'Use of carbohydrate-supplemented distillery spent wash as a medium for ethanol production by a thermotolerant strain of yeast at 45 degrees C'. Biotechnology Techniques, 10 (5):349-352. Available Online [Details]
Barron, N., Marchant, R., McHale, L., McHale, A. P. (1996) 'Ethanol production from cellulose at 45 degrees C using a hatch-fed system containing alginate-immobilized Kluyveromyces marxianus IMB3'. World Journal of Microbiology & Biotechnology, 12 (1):103-104. Available Online [Details]
Simpson, J., Brady, D., Rollan, A., Barron, N., McHale, L. & McHale, A.P.; (1995) 'Increased ethanol production during growth of electric-field stimulated Kluyveromyces marxianus IMB3 on lactose containing media'. Biotechnology Letters, 17 (7):757-760. [Details]
Ward, C., Nolan, A. M., Ohanlon, K., Mcaree, T., Barron, N., Mchale, L., Mchale, A. P. (1995) 'Production of Ethanol at 45-Degrees-C on Starch Containing Media by Mixed Cultures of the Thermotolerant, Ethanol-Producing Yeast Kluyveromyces-Marxianus Imb3 and the Thermophilic Filamentous Fungus Talaromyces-Emersonii Cbs-814.70'. Applied Microbiology and Biotechnology, 43 (3):408-411. Available Online [Details]
Simpson, J., Brady, D., Rollan, A., Barron, N., Mchale, L., Mchale, A. P. (1995) 'Increased Ethanol-Production during Growth of Electric-Field Stimulated Kluyveromyces-Marxianus Imb3 during Growth on Lactose-Containing Media at 45-Degrees-C'. Biotechnology Letters, 17 (7):757-760. Available Online [Details]
Nilsson, U., Barron, N., Mchale, L., Mchale, A. P. (1995) 'The Effects of Phosphoric-Acid Pretreatment on Conversion of Cellulose to Ethanol at 45-Degrees-C Using the Thermotolerant Yeast Kluyveromyces-Marxianus Imb3'. Biotechnology Letters, 17 (9):985-988. Available Online [Details]
Mccabe, A., Barron, N., Mchale, L., Mchale, A. P. (1995) 'Increased Efficiency of Substrate Utilization by Exposure of the Thermotolerant Yeast-Strain, Kluyveromyces-Marxianus Imb3 to Electric-Field Stimulation'. Biotechnology Techniques, 9 (2):133-136. Available Online [Details]
Barron, N., Marchant, R., Mchale, L., Mchale, A. P. (1995) 'Studies on the Use of a Thermotolerant Strain of Kluyveromyces-Marxianus in Simultaneous Saccharification and Ethanol Formation from Cellulose'. Applied Microbiology and Biotechnology, 43 (3):518-520. Available Online [Details]
Barron, N., Marchant, R., Mchale, L., Mchale, A. P. (1995) 'Partial Characterization of Beta-Glucosidase Activity Produced by Kluyveromyces-Marxianus Imb3 during Growth on Cellobiose-Containing Media at 45-Degrees-C'. Biotechnology Letters, 17 (10):1047-1050. Available Online [Details]
Nolan, A.M., Barron, N., Brady, D., McAree, T., Smith, D., McHale, L. & McHale, A.P.; (1995) 'Ethanol production at 45oC by an alginate-immobilised thermotolerant strain of Kluyveromyces marxianus IMB3 following growth on glucose containing media'. Biotechnology Letters, 16 (8):849-852. [Details]
Barron, N., Marchant, R., Mchale, L., Mchale, A. P. (1994) 'Growth of a Thermotolerant Ethanol-Producing Strain of Kluyveromyces-Marxianus on Cellobiose Containing Media'. Biotechnology Letters, 16 (6):625-630. Available Online [Details]
Nolan, A. M., Barron, N., Brady, D., Mcaree, T., Smith, D., Mchale, L., Mchale, A. P. (1994) 'Ethanol-Production at 45-Degrees by an Alginate-Immobilized Thermotolerant Strain of Kluyveromyces-Marxianus Following Growth on Glucose-Containing Media'. Biotechnology Letters, 16 (8):849-852. Available Online [Details]
Fleming, M., Barron, N., Mchale, L., Marchant, R., Mchale, A. P. (1993) 'Studies on the Growth of a Thermotolerant Yeast-Strain, Kluyveromyces-Marxianus Imb3, on Sucrose Containing Media'. Biotechnology Letters, 15 (12):1195-1198. Available Online [Details]
 

Conference Publications

Barron, N., Kumar, N., Sanchez, N., Gammell, P., Clynes, M. (2012) MicroRNAs as Potential Engineering Targets for Improvement of CHO Cell Production Phenotypes European Society for Animal Cell Technology 2009 , pp.3-11 Available Online [Details]
Sanchez, N., Lao, N., Gallagher, C., Aherne, S., Doolan, P., Clarke, C., Clynes, M., Barron, N. (2012) MiR-7 as a potential target for control of cell proliferation Available Online [Details]
Kumar, N., Sanchez, N., Gammell, P., Dowling, P., Henry, M., Meleady, P., Barron, N., Clynes, M. (2012) Proteomic Profiling of Temperature-Shifted CHO Cells to Identify Genes that Impact on Both Cell Growth and Recombinant Protein Productivity in Suspension Culture European Society for Animal Cell Technology 2011 , pp.95-107 Available Online [Details]
                       

Abstract

Rani, S,Mehta, JP,Barron, N,Doolan, P,Clynes, M,Jeppesen, PB,O'Driscoll, L (2010) TXNIP-IDENTIFIED AS A REGULATOR OF GLUCOSE-STIMULATED INSULIN SECRETION AND REACTIVE OXYGEN SPECIES IN MIN6 CELLS. Abstract [Details]
                                                                                       

Research

Research Interests

  • Targeted genetic engineering strategies to improve or control the production of recombinant therapeutic proteins from Chinese Hamster Ovary (CHO) cells.
  • Developing advanced recombinant DNA engineering strategies for improved phenotypic stability and selection of producer lines. This includes methods for targeted genome modification (using viruses and CRISPR-Cas9 approaches) and directed evolution.