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Brian Glennon

Associate Professor

School Of Chem & Bioprocess Engineering
Engineering Building
Belfield
Dublin 4

Tel: +353 1 7161954
Email: brian.glennon@ucd.ie

Professional

 

Associations

Association: Engineers Ireland, Function/Role: Chartered Engineer
Association: Institution of Chemical Engineers, Function/Role: Fellow
Association: American Society for Engineering Education, Function/Role: Member
Association: International Society of Pharmaceutical Engineers, Function/Role: Honorary Member
     

Conference Contributions

B Glennon; (2008) 'The Use of ReactIR and Lasentec FBRM to monitor and control bioprocesses. [Invited Lecture], 15th International Process Development Conference, Annapolis, US , 18-MAY-08 - 22-MAY-08.
Glennon, B.; (2006) 7th Biochemical Engineering Research Network (BERN) Research Conference. [Invited Lecture], 7th Biochemical Engineering Research Network (BERN) Research Conference, London, UK , 06-JAN-06 - 06-JAN-06.
Glennon, B.; (2005) The Evolving Role of Process Analytical Technology. [Invited Lecture], The Evolving Role of Process Analytical Technology, Brussels, Belgium , 25-OCT-05 - 26-OCT-05.
Glennon, B.; (2005) Process Analytical Technology - Implementation from Lab to Plant. [Invited Lecture], Process Analytical Technology - Implementation from Lab to Plant, Cork , 13-SEP-05 - 13-SEP-05.
O'Grady, D. and Glennon, B.; (2006) British Association for Crystal Growth Annual Conference. [Invited Lecture], British Association for Crystal Growth Annual Conference, Sheffield, UK , 04-SEP-06 - 06-SEP-06.
O'Grady, D. and Glennon, B.; (2005) AIChE Annual Meeting. [International Refereed Conference], AIChE Annual Meeting, Cincinnati, USA , 30-OCT-05 - 04-NOV-06.
Barrett, M., O'Grady, D., Glennon, B.; (2006) 2006 International Real Time Analytics Users' Conference. [Invited Lecture], 2006 International Real Time Analytics Users' Conference, Barcelona, Spain , 26-FEB-06 - 01-MAR-06.
Sen Gupta B., Farrell G. & Glennon B.; (2003) Hanging Drop Crystallization of Lysozyme. [Oral Presentation], 27th ACHEMA Congress on Chemical Engineering, Frankfurt am Main, Germany , 19-MAY-03 - 24-MAY-03.
Carey F. & Glennon B.; (2003) Distillation Shortcut Method for Non-Ideal Homogeneous Systems. [Oral Presentation], AIChE Spring Meeting, New Orleans, USA , 30-MAR-03 - 03-APR-03.
Jeffers P.T., Raposo S., Emilia Lima-Costa M., Kieran P. & Glennon B.; (2003) Application of the Focused Beam Reflectance Measurement Method to the Characterization of Plant Cells in Suspension Culture. [Oral Presentation], 225th ACS National Meeting, New Orleans, USA , 23-MAR-03 - 27-MAR-03.
O'Sullivan B. & Glennon B.; (2003) Identification of Polymorph Transition in Mannitol Crystallization Using FBRM, PVM, and XRPD. [Oral Presentation], Lasentec Users Forum, New York, USA , 24-FEB-03 - 26-FEB-03.
Barrett P., Glennon B. & O Sullivan B.; (2002) Characterizing the Metastable Zone Width and Solubility Curve Using Lasentec FBRM & PVM. [Oral Presentation], AIChE Annual Meeting, Indianapolis, USA , 03-NOV-02 - 08-NOV-02.
Pearson A., Jeffers P., Barrett P., Glennon B. & Kieran P.; (2002) In-Line Monitoring of Biological Systems. [Oral Presentation], AIChE Annual Meeting, Indianapolis, USA , 03-NOV-02 - 08-NOV-02.
Barrett P., Glennon B. & O Sullivan B.; (2002) Characterizing the Metastable Zone Width and Solubility Curve Using Lasentec FBRM & PVM. [Oral Presentation], International Symposium on Industrial Crystallization Inspiring Powder Technology, Tokyo, Japan , 13-NOV-02 - 14-NOV-02.

Committees

Committee : Engineers Ireland
Committee : European Federation of Chemical Engineering
Committee : Institution of Chemical Engineers
Committee : British Association of Crystal Growth
             

Publications

Books

Glennon, B., Kieran, P.M., Luyben, K.Ch.A.M.; (1996) 1st European Symposium on Biochemical Engineering Science. Dublin: ESBES. [Details]

Book Chapters

Glennon, B. ; (2001) 'Downstream Processing Design' In: Berovic, M., Kieran, P.M (eds). Proceedings Bioprocess Engineering Course. Croatia: National Institute of Chemisitry. [Details]
Glennon, B. ; (1998) 'Engineering Aspects of Downstream Processing' In: Berovic, M., Kieran, P.M (eds). Proceedings Bioprocess Engineering Course. Croatia: National Institute of Chemisitry. [Details]
 

Peer Reviewed Journals

Jessica Whelan, Stephen Craven, Brian Glennon (2012) 'In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors'. Biotechnology Progress, 25 (5):1355-1362. Available Online [DOI] [Details]
D. Duffy, N. Cremin, M. Napier, S. Robinson, M. Barrett, Hongxun Hao, Brian Glennon (2012) 'In situ monitoring, control and optimization of a liquid-liquid phase separation crystallization'. Chemical Engineering Science, 77 :112-121. Available Online [Details]
Hongxun Hao, Mark Barrett, Yun Hu, Weiyi Su, Steven Ferguson, Barbara Wood, and Brian Glennon (2012) 'The Use of in Situ Tools To Monitor the Enantiotropic Transformation of p-Aminobenzoic Acid Polymorphs'. Organic Process Research and Development, 16 (1):35-41. Available Online [Details]
Whelan, J.; Murphy, E.; Pearson, A.; Jeffers, P.; Kieran, P.; McDonnell, S.; Glennon, B (2012) 'Use of focussed beam reflectance measurement (FBRM) for monitoring changes in biomass concentration'. Bioprocess and Biosystems Engineering, 35 (6):963-975. Available Online [Details]
Barrett, M,Hao, HX,Maher, A,Hodnett, K,Glennon, B,Croker, D; (2011) 'In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization'. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 15 (3):681-687. [DOI] [Details]
Barrett, M,O'Grady, D,Casey, E,Glennon, B; (2011) 'The role of meso-mixing in anti-solvent crystallization processes'. Chemical Engineering Science, 66 (12):2523-2534. [DOI] [Details]
Barrett, M., McNamara, M., Hao, H., Barrett, P. & Glennon, B.; (2010) 'Supersaturation Tracking for the Development, Optimization and Control of Crystallization Processes'. Chemical Engineering Research & Design, 88 :1108-1119. Available Online [DOI] [Details]
Hao, H., Su, W., Barrett, M., Caron, V., Healy, A.M., Glennon, B.; (2010) 'A Calibration-Free Application of Raman Spectroscopy to the Monitoring of Mannitol Crystallization and its Polymorphic Transformation'. Organic Process Research and Development, 14 :1209-1214. Available Online [DOI] [Details]
Su, W., Hao, H., Barrett, M. & Glennon, B.; (2010) 'The Impact of Operating Parameters on the Polymorphic Transformation of d-Mannitol Characterized in Situ with Raman Spectroscopy, FBRM, and PVM'. Organic Process Research and Development, 14 :1432-1437. Available Online [DOI] [Details]
O'Grady, D., Barrett, M., Casey, E., Glennon, B.; (2007) 'The effect of mixing on the metastable zone width and nucleation kinetics in the anti-solvent crystallization of benzoic acid'. Chemical Engineering Research and Design, Transactions, 85 (A7):945-952. [Details]
Faulkner, E; Barrett, M; Okor, S; Kieran, P; Casey, E; Paradisi, F; Engel, P; Glennon, B; ; (2006) 'Use of fed-batch cultivation for achieving high cell densities for the pilot-scale production of a recombinant protein (phenylalanine dehydrogenase) in Escherichia coli'. Biotechnology Progress, 22 (3):889-897. [Details]
O'Sullivan, B; Glennon, B; ; (2005) 'Application of in situ FBRM and ATR-FTIR to the monitoring of the polymorphic transformation of D-mannitol'. Organic Process Research and Development, 9 (6):884-889. [Details]
Pearson, AP; Glennon, B; Kieran, PM; ; (2004) 'Monitoring of cell growth using the focused beam reflectance method'. Journal of Chemical Technology and Biotechnology, 79 (10):1142-1147. [Details]
Rishell, S; Casey, E; Glennon, B; Hamer, G; ; (2004) 'Characteristics of a methanotrophic culture in a membrane-aerated biofilm reactor'. Biotechnology Progress, 20 (4):1082-1090. [Details]
Glennon, B.; (2004) 'Experiences with the Development of Cross-disciplinary Projects in a Chemical Engineering Undergraduate Curriculum'. Chemical Engineering Education, 38 :296-300. [Details]
Rishell, S; Casey, E; Glennon, B; Hamer, G; ; (2004) 'Mass transfer analysis of a membrane aerated reactor'. Biochemical Engineering Journal, 18 (3):159-167. [Details]
Casey, E; Rishell, S; Glennon, B; Hamer, G; ; (2004) 'Engineering aspects of a mixed methanotrophic culture in a membrane-aerated biofilm reactor'. Water Science Technology, 49 (11-12):255-262. [Details]
Pearson A.P., Glennon B. & Kieran P.M.; (2003) 'Comparison of Two Methods of Morphological Characterisation of Filamentous Organisms'. Biotechnology Progress, 19 :1342-1347. [Details]
O'Sullivan, B; Barrett, P; Hsiao, G; Carr, A; Glennon, B; ; (2003) 'In situ monitoring of polymorphic transitions'. Organic Process Research and Development, 7 (6):977-982. [Details]
Pearson, AP; Glennon, B; Kieran, PM; ; (2003) 'Comparison of morphological characteristics of Streptomyces natalensis by image analysis and focused beam reflectance measurement'. Biotechnology Progress, 19 (4):1342-1347. [Details]
Jeffers, P; Raposo, S; Lima-Costa, ME; Connolly, P; Glennon, B; Kieran, PM; ; (2003) 'Focussed beam reflectance measurement (FBRM) monitoring of particle size and morphology in suspension cultures of Morinda citrifolia and Centaurea calcitrapa'. Biotechnology Letters, 25 (23):2023-2028. [Details]
Jeffers, PT; Raposo, S; Lima-Costa, ME; Kieran, P; Glennon, B; ; (2003) 'Application of the focused beam reflectance measurement method (FBRM) to the characterization of plant cells in suspension culture'. Abstracts of Papers of the American Chemical Society, 225 (NA):188-188. [Details]
Barrett, P; Glennon, B; ; (2002) 'Characterizing the metastable zone width and solubility curve using lasentec FBRM and PVM'. Chemical Engineering Research & Design, 80 (A7):799-805. [Details]
Casey, E., Glennon, B., and Hamer, G.; (2000) 'Biofilm Development in a Membrane-Aerated Biofilm Reactor: Effect of Intra-membrane Oxygen Pressure on Performance'. Bioprocess Engineering, 23 :457-465. [Details]
Casey, E; Glennon, B; Hamer, G; ; (2000) 'Biofilm development in a membrane-aerated biofilm reactor: Effect of flow velocity on performance'. Biotechnology and Bioengineering, 67 (4):476-486. [Details]
Casey E., Glennon B. & Hamer G.; (1999) 'Review of Membrane-Aerated Biofilm Reactors'. Resources Conservation and Recycling, 27 :203-215. [Details]
Barrett, P; Glennon, B; ; (1999) 'In-line FBRM monitoring of particle size in dilute agitated suspensions'. Particle &Amp; Particle Systems Characterization, 16 (5):207-211. [Details]
Casey, E; Glennon, B; Hamer, G; ; (1999) 'Oxygen mass transfer characteristics in a membrane-aerated biofilm reactor'. Biotechnology and Bioengineering, 62 (2):183-192. [Details]
Glennon B.; (1997) 'Computer System Validation in Multipurpose Biopharmaceutical Facilities'. Journal of Biotechnology, 59 :53-61. [Details]
Glennon, B., Al-Masry, W.A., MacLoughlin, P.F., and Malone, D.M.; (1993) 'Hydrodynamic Modelling in an Air-Lift Loop Bioreactor'. Chemical Engineering Communications, 121 :181-192. [Details]

Other Journals

O'Grady, D., Barrett, M., Casey, E.., Glennon, B.; (2006) 'The PAT toolbox for production scale-crystallization' Pharmaceutical Manufacturing 6 (5) :44-47. Available Online [Details]

Conference Publications

Morris, G; Hou, G; Barrett, M; Glennon, B (2012) Design and Characterisation of a Continuous Stirred Tank Crystallizer 2012 AIChE Annual Meeting [Details]
Glennon, B (2012) Robust Process Optimization ACT 18th Larson Workshop [Details]
O'Grady, D; Barrett, M; Casey, E; Glennon, B (2012) The Role of Meso-Mixing in Anti-Solvent Crystallization Processes 2012 AIChE Annual Meeting [Details]
Whelan, J; Craven, S; Glennon, B (2012) PAT-enabled bioreactor control as a tool for bioprocess optimisation BIOTECHNOLOGY IN ACTION: Stem Cells & Tissue Engineering, Biopharmaceutical Production and Cancer Biomarkers [Details]
Ronan Whelan, Mark Barrett, Hongxun Hao & Brian Glennon; (2011) Laboratory-Scale MSMPR Classification and Withdrawal Techniques 18th International Symposium on Industrial Crystallization [Details]
Hongxun Hao, Brian Glennon & Mark Barrett; (2011) In-situ Monitoring of Isolation and Transformation of Polymorphs using Process Analytical Technology 5th Asian Conference on Crystal Growth and Crystal Technology CGCT-5 [Details]
Brian Glennon; (2011) Pharmaceutical Crystallization Design and Optimization using Novel PAT methods 5th Asian Conference on Crystal Growth and Crystal Technology CGCT-5 [Details]
Stephen Craven, Jessica Whelan, Brian Glennon; (2011) Application of PAT to a fed-batch CHO320 fermentation process: Modelling, measurement and process control 1st European Congress of Applied Biotechnology [Details]
Stephen Craven, Jessica Whelan & Brian Glennon; (2011) Comparative Analysis of Controller technologies for a CHO320 fed-batch fermentation Advances in Process Control 9 [Details]
Steven Ferguson, Gary Morris, Hongxun Hao, Mark Barrett & Brian Glennon; (2011) PAT Based Design of Continuous Plug Flow Crystallizations 3rd Symposium on Continuous Flow Reactor Technology for Industrial Applications [Details]
Steven Ferguson, Gary Morris, Hongxun Hao, Mark Barrett & Brian Glennon; (2011) Design of Plug Flow Crystallizers 18th International Symposium on Industrial Crystallization [Details]
Damian Duffy, Neal Cremin, Michael Napier, Shane Robinson, Mark Barrett, Hongxun Hao & Brian Glennon; (2011) Prevention of Oiling Out During a Liquid-Liquid Phase Separation Crystallization 18th International Symposium on Industrial Crystallization [Details]
Damian Duffy, Neal Cremin, Michael Napier, Shane Robinson, Mark Barrett, Hongxun Hao & Brian Glennon; (2011) Control of Particle Size during a Liquid-Liquid Phase Separation Crystallization 18th International Workshop on Industrial Crystallization (BIWIC) [Details]
Mark Barrett, Hongxun Hao, Damian Duffy and Brian Glennon; (2011) AUTOMATED PROCESS DEVELOPMENT VIA NOVEL ATR-FTIR FEEDBACK CONTROL STRATEGIES 18th International Symposium on Industrial Crystallization [Details]
Jessica Whelan & Brian Glennon; (2011) Use of focussed beam reflectance measurement (FBRM) for monitoring changes in biomass concentration Bioprocessing, Biologics and Biotherapeutics Congress [Details]
Jessica Whelan & Brian Glennon; (2011) Focussed beam reflectance measurement (FBRM) as an optical monitoring technique for bioprocesses European Congress of Applied Biotechnology [Details]
Weiyi Su, Brian Glennon, Hongxun Hao, Mark Barrett; (2011) Investigation on the Spontaneous Nucleation and Polymorphic Transfromation of D-Mannitol 18th International Symposium on Industrial Crystallization [Details]
Mark Barrett & Brian Glennon; (2009) The optimization and scale-up of anti-solvent addition crystallization from lab to pilot plant 16th International Process Development Conference [Details]
Brian Rice & Brian Glennon; (2009) Use of ReactIR and FBRM for monitoring animal cell culture processes 16th International Process Development Conference [Details]
Mairtin McNamara & Brian Glennon; (2009) Eliminating micronisation using fine particle crystallization 16th International Process Development Conference [Details]
M. Barrett, E. Casey, B.Glennon; (2007) The impact of mixing times scales and process parameters on the optimisation and scale up of anti-solvent addition crystallisations AIChE Annual Meeting Salt Lake City, USA, [Details]
M. Barrett, E. Casey & B. Glennon; (2007) Anti-solvent crystallization scale-up: impact of addition profile, addition location and feed pipe diameter 14th International Process Development Conference Heidleberg, Germany, [Details]
D. O' Grady, M. Barrett & B. Glennon; (2006) Scale-up of Anti-Solvent Crystallization Using in Situ Tools and Computational Fluid Dynamics AIChE Annual Meeting San Francisco, USA, [Details]
M. Barrett, D. O'Grady, B. Glennon & E. Casey; (2006) The Application of CFD to the Multi-Scale Characterization of Anti-Solvent Addition Crystallization AIChE Annual Meeting San Francisco, USA, [Details]
Faulkner, E., Barrett, M., Okor, S., Paradisi, F., Engel, P. & Glennon, B.; (2005) The use of fed batch cultivation for achieving high cell densities for the pilot scale production of a recombinant protein (Phenylalanine dehydrogenase) in Escherichia coli AIChE Annual Meeting Cincinnati, USA, , 30-OCT-05 - 04-NOV-05 , pp.9086-9095 [Details]
O'Grady, D. & Glennon, B.; (2005) Use of In-Situ Instrumention to Characterise Anti-solvent Addition Crystallization AIChE Annual Meeting Cincinnati, USA, , 30-OCT-05 - 04-NOV-05 [Details]
                                                                                         

Research

Research Interests

Bioprocess Scale-up; Pharmaceutical Crystallization; Modelling of bioprocessing operations; Distillation Design Methods

Research

As part of the effort to produce new therapeutic treatments, it is necessary to ensure that these innovative products can be safely and reliably produced on a large-scale at a reasonable cost, and with minimum environmental impact. Throughout the chemical and biochemical manufacturing industries, one of the greatest technical challenges is the scale-up of processes from the laboratory to production-scale.

For many operations, this is straightforward, with the system obeying well-defined and well-established scale-up rules. This is especially true for large-scale continuous processing (e.g. distillation, extraction, filtration, etc.). However, for batch processing, scale-up is generally far more empirical, with heavy emphasis placed on the use of pilot-plant studies to provide a technological bridge between the laboratory and the production plant. Our research group is interested in developing better ways to more reliably facilitate such transfer.

In particular, the scale-up of biological processes has proved problematic. The response of a micro-organism to the processing environment in a production operation often proves to be significantly different from that observed in the laboratory. This variation in response is understandable when the different environments are considered in any detail. In laboratory equipment, typically shake-flasks, mixing, aeration and substrate distribution are all quite uniform. Pressure and temperature gradients are essentially non-existent, or present over such small scales as to be negligible. In production-scale systems, which may range from 100 litres up to 200 m3 in size, the extent of the variation in local values for all of these parameters may, by comparison, be very significant.

A similar problem faces the production of bulk pharmaceuticals, whether produced through chemical or biological synthesis. In particular, almost all pharmaceuticals are purified using batch crystallization in large stirred tanks (geometrically similar to bioreactors), which are poorly mixed due to the limitations of the vessel design.

The crystallization process is governed by kinetic transport phenomena, which are complex functions of the prevailing non-equilibrium conditions within the vessel. Thus, heterogeneities in the distribution of, for example, solute concentration or temperature will significantly alter the performance of the process-scale crystalliser compared to a well-mixed system, such as may typically prevail in the laboratory-scale vessel from which the process has been developed. As with bioreactor scale-up, the challenge is to determine the interactions between identifiable stages of the crystallisation system, in which different transport activities prevail.

A variety of technologies are employed as part of these investigations, ranging from pilot-scale bioreactors, to in-line imaging systems.

 

Research Projects

Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : The Role of the hydrodynamic flow field in the determination of crystallization kinetics
Start Date / End Date : 01-SEP-09 / 31-AUG-12
Sponsor : Enterprise Ireland (EI)
Title : Bioprocess Application of Process Analytical Technology (Bio PAT)
Start Date / End Date : 01-JAN-09 / 31-MAY-12
Sponsor : Enterprise Ireland (EI)
Title : PAT ILRP
Start Date / End Date : 23-SEP-08 / 23-NOV-08
Sponsor : Science Foundation Ireland (SFI)
Title : Solid State Pharmaceutical Cluster
Start Date / End Date : 01-DEC-07 / 30-NOV-12