UCD Research: Chemistry & Chemical Biology

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Dr Paul Evans B.Sc., D.Phil

Book Chapters:

Y. Kavanagh and P. Evans (2007) 'Pauson-Khand Reaction in the Synthesis of N- and O-Heterocycles' In: T. S. Kaufman and E. L. Larghi (eds). Modern Approaches to the Synthesis of O- and N- Heterocycles Vol 2. Trivandrum - 695023, Kerala, India: Research Signpost. [Details]

Peer Reviewed Journals:

Morgan BS, O'Byrne A, Murray C, Keegan D, Palacio C, Evans P, (2010) 'The thio-adduct facilitated, enzymatic kinetic resolution of 4-hydroxycyclopentenone and 4-hydroxycyclohexenone'. Organic and Biomolecular Chemistry, 8 (3):539-545. [DOI] [Details]

Evans P, Klein JE, Geoghegan K, MÃ©ral N, (2010) 'Selective generation of quaternary all-carbon-centres through Heck-cyclisations: synthesis of mesembrane'. Chemical Communications, 46 (6):937-939. [DOI] [Details]

Evans P, McLaughlin NP, (2010) 'Dihydroxylation of vinyl sulfones: stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone'. Journal of Organic Chemistry, 75 (2):518-521. [DOI] [Details]

Evans P, Kelleher S, Quesne PY, (2009) 'Diastereoselective functionalisation of benzo-annulated bicyclic sultams: Application for the synthesis of cis-2,4-diarylpyrrolidines'. Journal of Organic Chemistry, 5 . [DOI] [Details]

Evans P, Klein JE, MÃ¼ller-Bunz H, (2009) 'Studies concerning the electrophilic amino-alkene cyclisation for the synthesis of bicyclic amines'. Organic and Biomolecular Chemistry, 7 (5):986-995. [DOI] [Details]

P. Evans, A. T. L. Lee and E. J. Thomas (2008) 'Synthesis of a 6-Aryloxymethyl-5-hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-one: a Muscarinic (M3) Antagonist'. Organic and Biomolecular Chemistry, 6 (12):2158-2167. [Details]

B. Bradshaw, P. Evans, J. Fletcher, A. T. L. Lee, P. G. Mwashimba, D. Oehlrich, E. J. Thomas, R. H. Davies, B. C. P. Allen, K. J. Broadley, A. Hamrouni and C. Escargueil (2008) 'Synthesis of 5-Hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-ones; Selective Antagonists of Muscarinic (M3) Receptors'. Organic and Biomolecular Chemistry, 6 (12):2138-2157. [Details]
A. O¿Byrne and P. Evans, (2008) 'Rapid synthesis of the tetrahydroquinoline alkaloids; angustureine, cuspareine and galipinine'. Tetrahedron, 64 (35):8067-8072. [Details]
M. J. Stefanko, Y. K. Gun¿ko and P. Evans (2008) 'Synthesis of Functionalised Polyethylene Glycol Derivatives of Naproxen for Biomedical Applications'. Tetrahedron, 64 (44):10132-10139. [Details]
M. Iqbal, P. Duffy, G. Cloughley, B. Allan, P. Evans, X. Verdaguer, A. Riera and A. Lledó (2008) 'The Conjugate Addition/Peterson Olefination Reaction for the Preparation of Cross-Conjugated Cyclopentenone, PPAR-g Ligands'. Organic and Biomolecular Chemistry, . [Details]
Y. Kavanagh, C. M. Chaney, J. Muldoon and P. Evans (2008) 'Iridium Catalyst Mediated Isomerisation-Cyclisation of Pauson-Khand Derived Bicyclic Allylic Alcohols'. Journal of Organic Chemistry, 73 . [Details]
J. Klein, H. Müller-Bunz, Y. Ortin and P. Evans (2008) 'Formation of Cyclic Sulfonamides via an Unusual 8-endo -trig Heck Olefination Reaction0'. Tetrahedron Letters, 49 . [Details]
Byrne, S. J., le Bon, B., Corr, S. A., Stefanko, M., O'Connor, C., Gun'ko, Y. K., Rakovich, Y. P., Donegan, J. F., Williams, Y., Volkov, Y., Evans, P. (2007) 'Synthesis, Characterisation, and Biological Studies of CdTe Quantum Dot-Naproxen Conjugates'. ChemMedChem, 2 . [Details]
Evans, P. (2007) 'The Double Reduction of Cyclic Sulfonamides for the Synthesis of (4S-Phenylpyrrolidin-4R-yl)methanol and 2S-Methyl-4S-phenylpyrrolidine'. Journal of Organic Chemistry, 72 . [Details]
Banide E. V., Müller-Bunz H., Manning A. R., Evans P. and McGlinchey M. J. (2007) 'X-Ray Crystal Structure of an Unprecedented Alkene-Pentacarbonyldicobalt-Alkyne Complex: First Isolation of a Stable Magnus-Type Pauson-Khand Reaction Intermediate'. Angewandte Chemie International Edition, 46 . [Details]
Kelleher, S., Muldoon, J., Müller-Bunz, H. and Evans, P. (2007) 'Studies concerning the double reduction of Diels'Alder derived bicylic sulfonamides'. Tetrahedron Letters, 48 . [Details]
Morgana, BS; Roberts, SM; Evans, P; (2006) 'Enzymatic kinetic resolution of 1,1-dioxo-2,3-dihydro-1H-1 lambda(6)-thiophen-3-ol via temporary derivatisation'. Tetrahedron Letters, 47 (30):5273-5276. [Details]
Duffy, P. E., Quinn, S. M., Roche, H. M. Evans, P (2006) 'Synthesis of trans-Vaccenic Acid and cis-9-trans-11-Conjugated Linoleic Acid'. TETRAHEDRON, . [Details]
Evans, P., Johnson, P. Taylor, R. J. K. (2006) 'The Epoxy-Ramberg-Backlund Reaction (ERBR): A Sulfone Based Method for the Synthesis of Allylic Alcohols'. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, . [Details]
Evans, P., McCabe, T., Morgan, B. S. and Reau, S. (2005) 'The Double Reduction of Cyclic Aromatic Sulfonamides: A Novel Method for the Synthesis of 2- and 3-Aryl Substituted Cyclic Amines'. ORGANIC LETTERS, . [Details]
Iqbal, M; Evans, P; Lledo, A; Verdaguer, X; Pericas, MA; Riera, A; Loeffler, C; Sinha, AK; Mueller, MJ; (2005) 'Total synthesis and biological activity of 13,14-dehydro-12-oxo-phytodienoic acids (deoxy-J(1)-phytoprostanes)'. Chembiochem, 6 (2):276-280. [Details]
J. F. Bickley, A. Ciucci, P. Evans, S. M. Roberts, N. Ross and M. G. Santoro (2004) 'Reactions of some Cyclopentenones with Selected Cysteine Derivatives and Biological Activities of the Product Thioethers'. BIOORGANIC AND MEDICINAL CHEMISTRY, . [Details]
M. Iqbal, Y. Li and P. Evans (2004) 'Synthesis of Δ12,14-15-Deoxy-PG-J1 Methyl Ester and epi-Δ 12-15-Deoxy-PG-J1'. TETRAHEDRON, . [Details]
B. S. Morgan, D. Hoenner, P. Evans and S. M. Roberts (2004) 'acile Biocatalytic Syntheses of Optically Active 4-Hydroxycyclohex-2-enone and 4-Benzylthiacyclopent-2-enone'. TETRAHEDRON: ASYMMETRY, . [Details]
M. Iqbal and P. Evans (2003) 'Conjugate Addition-Peterson Olefination Reactions: Expedient Routes to Cross Conjugated Dieneones'. TETRAHEDRON LETTERS, . [Details]
P. Evans and M. Leffray (2003) 'Asymmetric Dihydroxylation of Vinyl Sulfones: Routes to Enantioenriched α-Hydroxyaldehydes and the Enantioselective Syntheses of Furan-2(5H)-ones'. TETRAHEDRON, . [Details]
M. Iqbal, N. Vyse, J. Dauvergne and P. Evans (2002) 'Microwave Promoted Pauson-Khand Reactions'. TETRAHEDRON LETTERS, . [Details]
P. Evans, R. Grigg and M. York (2000) 'Ring Closing Metathesis Reactions of Isoquinoline and β-Carboline Enamines'. TETRAHEDRON LETTERS, . [Details]
P. Evans and R. J. K. Taylor (1997) 'Novel Tandem Conjugate Addition-Ramberg-Bäcklund Rearrangements'. SYNLETT, . [Details]
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Other Journals:

Bickley, J. F., Evans, P., Meek, A., Morgan, B. S. Roberts, S. M. (2006) 'Novel Preparation of (-)-4-Hydroxycyclohex-2-enone: Reaction of 4-Hydroxycyclohex-2-enone and 4-hydroxycyclopent-2-enone with some Thiols' Tetrahedron Asymmetry . [Details]