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Researchers at UCD

researcher

Amanda McCann

Associate Professor and Head of Pathology

Conway Institute
School of Medicine
UCD Conway Institute of Biomolecular and Biomedical Science
Belfield
Dublin 4

Tel: 353 1 716 6742
Email: amanda.mccann@ucd.ie

Biography

Amanda McCann is a PI and UCD Conway Fellow in the UCD Conway Institute of Biomolecular and Biomedical Science. She is also Associate Professor and Head of Pathology in the UCD School of Medicine. 

Her groups specific interest is focused on understanding the mechanisms underlying chemoresistance for women presenting with breast and ovarian cancer. These interests have led to collaborations with oncologists and histopathologists across the country and with colleagues based in the Ireland East Hospital Group (IEHG) NIBRT, veterinary science, chemistry, biomedical engineering and physics. Recently in collaboration with an Irish Company Theya Lingereie, and built on a pilot study with ARCH, she is investigating the clinical and social Impact of the Theya Lingeries Recovery Bra for women who have undergone breast mastectomy.

Currently, she is the Academic Lead on the establishment of the UCD Academic Centre in Translational Oncology (ACTO).

In relation to patient advocate groups, she previously was a Co-Director of IPPOSI, and currently is a research advisor to Debra Ireland.

She is also the Chair of the School of Medicine's Student Summer Research Awards, the Director of the UCD Academic Centre Translational Oncology.

Professional

 

Associations

Association: UCD Academic Centre Translational Oncology, Function/Role: Director
Association: Irish Association for Cancer Research (IACR), Function/Role: President
Association: International Cellular Senescence Association (ICSA), Function/Role: Founder Member and current committee member
     

Conference Contributions

Greene, L. M., Twal, W. O., Donovan, N. O., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2001) Proteolytic processing of fibulin-1 is linked with estrogen receptor status in human breast tumours and tumour-derived cell lines. [Poster Presentation], The Irish Association for Cancer Research/Irish Society of Medical Oncology Joint Cancer Research Meeting, Cork , 27-SEP-01 - 28-SEP-01.
Greene, L. M., Twal, W. O., Maguire, T., McCann, A., Dervan, P., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2001) Proteolytic processing of fibulin-1 in human breast tumors is linked with estrogen receptor status. American Association for Cancer Research. [Poster Presentation], 92nd Annual Meeting, New Orleans , 24-MAR-01 - 28-MAR-01.
Greene, L. M., Twal, W. O., Donovan, N. O., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M. presented by L. M. Greene.; (2001) *. [Poster Presentation], 1st Annual Conway Institute Festival of Research, Dublin , 13-SEP-01.
Gubbins, L.; Weiner-Gorzel, K.; Sharma, S.; Cooke, L.; Salvati, A.; Simpson, J.; Dawson, K.; Kell, M. and McCann, A. (2014) Transfer of senescent signals in a hypoxic tumor microenvironment: A mechanism of tumor cell survival mediated by exosomes. AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment, San Diego, CA , 26-FEB-13 - 01-MAR-14.
Sharma, SDJ; Gubbins, L; Weiner-Gorzel, K; Simpson, J; McCann, A; Kell, M (2014) The impact of TSG101 in triple-negative breast cancers. [Poster Presentation], 2014 ASCO Annual Meeting, Chicago , 30-MAY-14 - 03-JUN-14.
9. McGrogan B, Phelan S, Fitzpatrick P, Maguire A, Prencipe M, Brennan D, Doyle E, O¿Grady A, Kay E, Furlong F, McCann A. (2015) Spindle assembly checkpoint protein expression correlates with cellular proliferation and shorter time to recurrence in ovarian cancer. [Poster Presentation], The Ireland-Northern Ireland ¿ National Cancer Institute (NCI)Cancer Consortium Conference, Queen's University Belfast , 11-MAY-15 - 13-MAY-15.
Greene, L. M., Twal, W. O., Donovan, N. O., McCann, A. H., Dervan, P. A., Duffy, M. J., Argraves, W. S., and Gallagher, W. M.; (2001) Proteolytic processing of fibulin-1 is linked with estrogen receptor status in human breast tumours and tumour-derived cell lines. [Oral Presentation], The Irish Association for Cancer Research/Irish Society of Medical Oncology Joint Cancer Research Meeting, Cork, Cork , 27-SEP-01 - 28-SEP-01.

Committees

Committee : Student Summer Research Awards

Employment

Employer: University College Dublin
Position: College Lecturer
Employer: University College Dublin
Position: President`s Research Award
Employer: University College Dublin
Position: Special Lecturer
Employer: UCD
Position: Senior Lecturer

Education

Year 1983 Institution: Trinity College Dublin
Qualification: BA (Mod) Subject:
Year 1992 Institution: Trinity College Dublin
Qualification: PhD Subject:
         

Publications

     

Peer Reviewed Journals

Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, Lindsay S, Gubbins L, Cannon A, Sharpe D, O'Sullivan J, Murphy M, Madden SF, Kell M, McCann A, Furlong F (2015) 'Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells'. Cancer medicine, 4 (5):745-758. [DOI] Link to full text [Details]
Elma A. O¿Reilly, E. A.; Gubbins, L.; Sharmaa, S.; Tully, R.; Zhing Guang, M. H.; Weiner-Gorzel, K.; McCaffrey, J.; Harrison, M.; Furlong, F.; Malcolm Kell, M.; and McCann, A. (2015) 'The fate of chemoresistance in triple negative breast cancer (TNBC)'. BBA Clinical, 3 :257-275. [Details]
Joyce H, McCann A;Clynes M;Larkin A (2015) 'Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism'. Expert Opinion on Drug Metabolism and Toxicology, 11 (5):795-809. [DOI] [Details]
McGrogan B, Phelan S, Fitzpatrick P, Maguire A, Prencipe M, Brennan D, Doyle E, O'Grady A, Kay E, Furlong F, McCann A. (2014) 'Spindle assembly checkpoint protein expression correlates with cellular proliferation and shorter time to recurrence in ovarian cancer'. Human Pathology, 45 (7):1509-1519. [DOI] [Details]
McElnea, E. M., Hughes, E., McGoldrick, A., McCann, A., Quill, B., Docherty, N., Irnaten, M., Farrell, M., Clark, A. F., O'Brien, C. J., Wallace, D. M. (2014) 'Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells'. BMC Ophthalmology, 14 :153. Available Online [Details]
d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ (2014) 'The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer'. PLoS ONE, 9 (6). [DOI] [Details]
Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K (2014) 'Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes'. Psychiatric Genetics, . [DOI] [Details]
Watson, C.J. and Collier, P. and Tea, I. and Neary, R. and Watson, J.A. and Robinson, C. and Phelan, D. and Ledwidge, M.T. and Mcdonald, K.M. and Mccann, A. and Sharaf, O. and Baugh, J.A. (2014) 'Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype'. Human Molecular Genetics, 23 (8):2176-2188. Available Online [DOI] [Details]
Zhou, ZM,McCann, A,Litrup, E,Murphy, R,Cormican, M,Fanning, S,Brown, D,Guttman, DS,Brisse, S,Achtman, M (2013) 'Neutral Genomic Microevolution of a Recently Emerged Pathogen, Salmonella enterica Serovar Agona'. PLoS Genetics, 9 . [DOI] [Details]
O Leary PC, Penny SA, Dolan RT, Kelly CM, Madden SF, Rexhepaj E, Brennan DJ, McCann AH, Pontén F, Uhlén M, Zagozdzon R, Duffy MJ, Kell MR, Jirström K, Gallagher WM (2013) 'Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer'. BMC Cancer, 13 . [DOI] [Details]
Furlong F, Fitzpatrick P, Phelan S, Maguire A, McGrogan B, Prencipe M, McGoldrick A, McGettigan P, Brennan D, Gallagher M, Sharon O'Toole S, Sheils O, O'Grady A, Kay EW, O'Leary J, McCann A. (2012) 'Low MAD2 expression associates with reduced progression free survival in patients with serous papillary epithelial ovarian cancer'. Journal of Pathology, 226 (5):746-755. [Details]
Saldova R, McCann A;Rudd PM (2012) 'Commentary on paper: 5-Aza-2'-deoxycytidine increases sialyl Lewis X on MUC1 by stimulating ¿¿-galactoside:¿¿2,3-sialyltransferase 6 gene (Chachadi et al.)'. International Journal of Biochemistry and Cell Biology, 44 (5). [DOI] [Details]
Furlong, F,Fitzpatrick, P,O'Toole, S,Phelan, S,McGrogan, B,Maguire, A,O'Grady, A,Gallagher, M,Prencipe, M,McGoldrick, A,McGettigan, P,Brennan, D,Sheils, O,Martin, C,Kay, EW,O'Leary, J,McCann, A (2012) 'Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer'. Pathology, 226 :746-755. [DOI] [Details]
Smith, JD,Meehan, MH,Crean, J,McCann, A; (2011) 'Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest'. Cellular and Molecular Life Sciences, 68 :2493-2498. [DOI] [Details]
Radka Saldova, Eugene Dempsey, Marta Pérez-Garay, Karina Mariño, Jenny A Watson, Alfonso Blanco-Fernández, Weston B Struwe, David J Harvey, Stephen F Madden, Rosa Peracaula, Amanda McCann, Pauline M Rudd (2011) '5-AZA-2'-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer'. Epigenetics : official journal of the DNA Methylation Society, 6 (11):1362-1372. [DOI] [Details]
Doi T, Puri P, McCann A, Bannigan J, Thompson J; (2011) 'Epigenetic effect of cadmium on global de novo DNA hypomethylation in the cadmium-induced ventral body wall defect (VBWD) in the chick model'. Toxicological sciences : an official journal of the Society of Toxicology, 120 (2):475-480. [DOI] [Details]
Jin Y, Amaral A, McCann A, Brennan L; (2011) 'Homocysteine levels impact directly on epigenetic reprogramming in astrocytes'. Neurochemistry International, . [DOI] [Details]
Prencipe, M,McGoldrick, A,Perry, AS,O'Grady, A,Phelan, S,McGrogan, B,Fitzpatrick, P,Watson, JA,Furlong, F,Brennan, DJ,Lawler, M,Kay, E,McCann, A; (2010) 'MAD2 downregulation in hypoxia is independent of promoter hypermethylation'. Cell cycle (Georgetown, Tex.), 9 :2856-2865. [DOI] [Details]
Watson JA, Watson CJ, McCann A, Baugh J; (2010) 'Epigenetics, the epicenter of the hypoxic response'. Epigenetics : official journal of the DNA Methylation Society, 5 (4):293-296. [Details]
Watson, J. A.,Watson, C. J.,McCrohan, A. M.,Woodfine, K.,Tosetto, M.,McDaid, J.,Gallagher, E.,Betts, D.,Baugh, J.,O'Sullivan, J.,Murrell, A.,Watson, R. W.,McCann, A.; (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Hum Mol Genet, 18 (1919):3594-6043594. Available Online [Details]
McCann A, Watson JA, Burling K, Fitzpatrick P, Kay E, Kelly J, Fitzpatrick JM, Dervan PA, ; (2009) 'Urinary insulin-like growth factor 2 identifies the presence of urothelial carcinoma of the bladder'. BJU International, 5 (NA):694-697. [DOI] [Details]
Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Klinger R, Furlong F, Harrison M, O'Connor D, Roninson IB, O'Sullivan J, McCann A; (2009) 'Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro'. British Journal of Cancer, 101 (11):1900-1908. [DOI] [Details]
Gallagher, E. M.,O'Shea, D. M.,Fitzpatrick, P.,Harrison, M.,Gilmartin, B.,Watson, J. A.,Clarke, T.,Leonard, M. O.,McGoldrick, A.,Meehan, M.,Watson, C.,Furlong, F.,O'Kelly, P.,Fitzpatrick, J. M.,Dervan, P. A.,O'Grady, A.,Kay, E. W.,McCann, A.; (2008) 'Recurrence of urothelial carcinoma of the bladder: a role for insulin-like growth factor-II loss of imprinting and cytoplasmic E-cadherin immunolocalization'. Clin Cancer Res, 14 (21):6829-38. Available Online [Details]
McCann A, McGrogan BT, Gilmartin B, Carney DN, ; (2008) 'Taxanes, microtubules and chemoresistant breast cancer'. 1785 (2):96-132. [DOI] [Details]
Mc Cormack, O., Chung, W. Y., Fitzpatrick, P., Cooke, F., Flynn, B., Harrison, M., Fox, E., Gallagher, E., Mc Goldrick, A., Dervan, P. A., Mc Cann, A., Kerin, M. J., ; (2008) 'Growth arrest-specific gene 6 expression in human breast cancer'. British Journal of Cancer, 98 (6):1141-1146. [DOI] [Details]
Armstrong, ME,Gantier, M,Li, LL,Chung, WY,McCann, A,Baugh, JA,Donnelly, SC; (2008) 'Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism'. Journal of Immunology, 180 :7125-7133. [Details]
Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F, Flynn B, Harrison M, Fox E,Gallagher E, McGoldrick A, Dervan PA, McCann A, Kerin MJ.; (2008) 'Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer: Progesterone receptor B hypermethylation in breast cancer'. Breast Cancer Research and Treatment, 111 :45-53. [Details]
Rexhepaj, E., Brennan, D. J., Holloway, P., Kay, E. W., McCann, A. H., Landberg, G., Duffy, M. J., Jirstrom, K., and Gallagher, W. M. ; (2008) 'Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of estrogen and progesterone receptor levels in breast cancer'. Breast cancer research : BCR, 10 (5):R89. [DOI] [Details]
Kerin MJ, Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F, Flynn B, Harrison M, Fox E, Gallagher E, Goldrick AM, Dervan PA, Mc Cann A, ; (2008) 'Growth arrest-specific gene 6 expression in human breast cancer'. Journal of Cancer, 98 (6):1141-1146. [DOI] [Details]
Meehan, M.,Melvin, A.,Gallagher, E.,Smith, J.,McGoldrick, A.,Moss, C.,Goossens, S.,Harrison, M.,Kay, E.,Fitzpatrick, J.,Dervan, P.,Mc Cann, A.; (2007) 'Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder'. Genes Chromosomes Cancer, 46 (6):587-93. [Details]
Hosey, AM,Gorski, JJ,Murray, MM,Quinn, JE,Chung, WY,Stewart, GE,James, CR,Farragher, SM,Mulligan, JM,Scott, AN,Dervan, PA,Johnston, PG,Couch, FJ,Daly, PA,Kay, E,McCann, A,Mullan, PB,Harkin, DP; (2007) 'Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer'. Journal of the National Cancer Institute, 99 :1683-1694. [DOI] [Details]
O'Sullivan, FM,Murphy, SK,Simel, LR,McCann, A,Callanan, JJ,Nolan, CM; (2007) 'Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation'. Evolution and Development, 9 :579-589. [Details]
Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F , Flynn B , Harrison M, Fox E, Gallagher E, Mc Goldrick A, Dervan PA, McCann A, Kerin MJ; (2007) 'Progesterone Receptor B (PRB) promoter hypermethylation in sporadic breast cancer'. Breast Cancer Research and Treatment, . [Details]
O'Brien SL, Fagan A, Fox EJ, Millikan RC, Culhane AC, Brennan DJ, McCann AH,; (2007) 'CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer'. International Journal of Cancer, 120 (7):1434-1443. [Details]
Gallagher, E,Goldrick, AM,Chung, WY,Cormack, OM,Harrison, M,Kerin, M,Dervan, PA,Cann, AM; (2006) 'Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer'. GENOMICS, 88 (1):12-17. [DOI] [Details]
Carder, PJ; Murphy, CE; Dervan, P; Kennedy, M; McCann, A; Saunders, PTK; Shaaban, AM; Foster, CS; Witton, CJ; Bartlett, JMS; Walker, RA; Speirs, V; ; (2005) 'A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ER beta in archival formalin-fixed paraffin embedded human breast tissue'. Breast Cancer Research and Treatment, 92 (3):287-293. [Details]
Balfe P, McCann A, McGoldrick A, McAllister K, Kennedy M, Dervan P, Kerin MJ.; (2004) 'Estrogen receptor alpha and beta profiling in human breast cancer'. European Journal of Surgical Oncology, 30 (5):469-474. [Details]
Mc Cormack, OM; Mc Cann, AH; Chung, WY; Cooke, F; Flynn, B; Gallagher, E; Mc Goldrick, A; Welch, HM; Dervan, PA; Kerin, MJ; ; (2004) 'Progesterone receptor B promoter hypermethylation in breast carcinoma; correlation with mRNA and protein levels'. Breast Cancer Research and Treatment, 88 (NA):176-176. [Details]
Shahbazi, RI; McCann, A; Frawley, A; Doran, P; Chung, WY; Dervan, P; Kerin, MJ; ; (2004) 'Validation of gamma-actin as a potential target in breast cancer'. British Journal of Surgery, 91 (9):1216-1216. [Details]
Balfe, P; McCann, A; McGoldrick, A; Kennedy, M; McAllister, K; Dervan, P; Kerin, MJ; ; (2003) 'Antiestrogen therapy could be harmful in patients with oestrogen receptor-beta dominant tumours'. British Journal of Surgery, 90 (NA):102-103. [Details]
Cooke, FJ; McCann, AH; Balfe, P; McAlister, K; Kennedy, M; Dervan, P; Kerin, MJ; ; (2003) 'Epigenetic control of the oestrogen receptor genes in breast cancer'. British Journal of Surgery, 90 (NA):42-43. [Details]
Greene, LM, Twal, WO, Duffy, MJ, McDermott, EW, Hill, AD, O'Higgins, NJ, McCann, A, Dervan, P, Argraves, W, Gallagher, WM, ; (2003) 'Elevated expression and altered processing of fibulin-1 protein in human breast cancer'. British Journal of Cancer, 88 (6):871-878. [Details]
Cooke, FJ; Balfe, P; McCann, AH; Dervan, P; Kennedy, M; Kerin, M; ; (2002) 'An investigation into the methylation status of oestrogen receptor beta and its subsequent expression in human breast cancer'. European Journal of Human Genetics, 10 (NA):83-84. [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; ; (2002) 'Has bladder cancer MET its maker?'. Pathology, 198 (NA):41-41. [Details]
McGoldrick, A; McCann, A; Fitzpatrick, J; Smith, J; Dervan, PA; ; (2002) 'Microarray generated oncogene copy number profiling in human bladder cancer'. British Journal of Cancer, 86 (NA):23-23. [Details]
Pedersen, IS; Dervan, P; McGoldrick, A; Harrison, M; Ponchel, F; Speirs, V; Isaacs, JD; Gorey, T; McCann, A; ; (2002) 'Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer'. Human Molecular Genetics, 11 (12):1449-1453. [Details]
Fabre, A,McCann, AH,O'Shea, D,Broderick, D,Keating, G,Tobin, B,Gorey, T,Dervan, PA; (1999) 'Loss of heterozygosity of the Wilms' tumor suppressor gene (WT1) in in situ and invasive breast carcinoma'. Human Pathology, 30 :661-665. [Details]
Pedersen, I.S., Dervan, P.A., Broderick, D., Harrison, M., Miller, N., Delany, E., O'Shea, D., Costello, P., McGoldrick, A., Keating, G., Tobin, B., Gorey, T., and McCann, A.; (1999) 'Frequent loss of imprinting of PEG1/MEST in invasive breast cancer'. Cancer Research, 59 (21):5449-5451. [Details]
Costello, PJ; McCann, AH; Gorey, T; Dervan, PA; ; (1999) 'Some non high grade ductal carcinomas in situ are polyclonal'. Laboratory Investigation, 79 (1):17-17. [Details]
Miller, N; McCann, A; O'Connell, D; Pedersen, IS; Spiers, V; Gorey, T; Dervan, PA; ; (1998) 'Mono-allelic expression of the Mas proto-oncogene in human breast tissue'. European Journal of Human Genetics, 6 (NA):147-147. [Details]
McGarry, Y; Lewis, S; McCann, A; Moran, E; Sinha, SK; Kelehan, P; Dervan, P; ; (1998) 'Distribution of the antigen recognised by the monoclonal antibody P1H10 in ovarian and breast tissue'. British Journal of Cancer, 78 (NA):68-68. [Details]
Costello, P; McCann, AH; Moore, E; Gorey, T; Dervan, PA; ; (1998) 'Clonal analysis of breast DCIS on microdissected tumour cells using differential methylation of HUMARA (Xq12)'. LABORATORY INVESTIGATION, 78 (1):18-18. [Details]
Miller, N,McCann, AH,O'Connell, D,Pedersen, IS,Spiers, V,Gorey, T,Dervan, PA; (1997) 'The MAS proto-oncogene is imprinted in human breast tissue'. Genomics, 46 :509-512. [Details]
McCann AH, Miller N, O'Meara A, Pedersen I, Keogh K, Gorey T, Dervan PA; (1996) 'Biallelic expression of the IGF2 gene in human breast disease'. Human Molecular Genetics, 5 (8):1123-1127. [Details]
MCCANN, AH; KIRLEY, A; CARNEY, DN; CORBALLY, N; MAGEE, HM; KEATING, G; DERVAN, PA; ; (1995) 'AMPLIFICATION OF THE MDM2 GENE IN HUMAN BREAST-CANCER AND ITS ASSOCIATION WITH MDM2 AND P53 PROTEIN STATUS'. British Journal of Cancer, 71 (5):981-985. [Details]
Costello P, McCann A, Carney DN, Dervan PA.; (1995) 'Prognostic Significance of Microvessel density in lymph node negative breast carcinoma'. Human Pathology, 26 (11):1181-1184. [Details]
McCann, A.H., Dervan, P.A., O'Regan, M., Codd, M.B., Gullick, W.J., Tobin, B.M., and Carney, D.N.; (1991) 'Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer'. Cancer Research, 51 (12):3296-3303. [Details]
 

Conference Publications

Ivers, L; Cummings, BK; McCann, A; Itasaki, N (2013) The effect of microenvironment on breast cancer cells cultured in 3D matrix Irish Association for Cancer Research Annual Meeting [Details]
Brennan, D.J., Hewitt, S.M., Fox, E.J.P., O'Brien, S., Jirstrom, K., Duffy, M.J., Landberg, G., McCann, A. & Gallagher, W.M.; (2006) Automated quantitative analysis of immunohistochemistry linked to clinical outcome Automated quantitative analysis of immunohistochemistry linked to clinical outcome Dublin, Ireland, [Details]
   

Editorial

Saldova, R,McCann, A,Rudd, PM (2012) Commentary on paper: 5-Aza-2 '-deoxycytidine increases sialyl Lewis X on MUC1 by stimulating beta-galactoside:alpha 2,3-sialyltransferase 6 gene (Chachadi et al.). Editorial [DOI] [Details]
Chai, K,Kitamura, K,McCann, A,Wu, XR (2010) The Epithelium-Molecular Landscaping for an Interactive Barrier. Editorial [DOI] [Details]
                 

Abstract

McEvoy, L,O'Toole, S,Spillane, C,Stordal, B,Gallagher, M,Martin, C,Norris, L,Gleeson, N,McGoldrick, A,Furlong, F,McCann, A,Sheils, O,O'Leary, J (2013) Novel Hypoxia-Associated Markers of Chemoresistance in Ovarian Cancer. Abstract [Details]
McEvoy, L,O'Toole, S,Spillane, C,Stordal, B,Gallagher, M,Martin, C,Norris, L,Gleeson, N,McGoldrick, A,Furlong, F,McCann, A,Sheils, O,O'Leary, J (2013) Novel Hypoxia-Associated Markers of Chemoresistance in Ovarian Cancer. Abstract [Details]
O'Reilly, EA,Furlong, F,Salman, R,Bambury, R,Harrison, M,Drew, G,Kelly, C,O'Grady, A,Kay, E,McCann, A,Kell, M (2012) Senescent and Autophagic cellular fates predict chemoresponse in TNBC. Abstract [Details]
Weiner-Gorzel, K,O'Reilly, E,McGoldrick, A,Fitzpatrick, P,O'Toole, S,Maguire, A,Kay, E,O'Leary, J,McCann, A,Furlong, F (2012) Mitotic Arrest Deficiency Protein 2 (MAD2) and Histone Deacetylase 6 (HDAC6) Present a Complex Relationship in Their Regulation and Expression and Subsequent Impact on Chemoresponsiveness. Abstract [Details]
Hazel, K,Toh, V,McGoldrick, A,McCann, A,Furlong, F (2011) COMPARATIVE MAD2 EXPRESSION AND CHEMOSENSITIVITY ANALYSES IN EPITHELIAL OVARIAN CANCER (EOC) IN VITRO. Abstract [Details]
Toh, V,Hazel, K,McCann, A,Furlong, F (2011) THE FATE OF CHEMORESISTANCE IN EPITHELIAL OVARIAN CARCINOMA (EOC). Abstract [Details]
Furlong, F,Prencipe, M,McGoldrick, A,McGettigan, P,Carney, D,Doyle, E,Kay, F,McCann, A (2010) miR-433 overexpression attenuates the spindle assembly checkpoint response to paclitaxel. Abstract [DOI] [Details]
Woods, G,McCann, A,Phelan, S (2010) MEMBRANOUS STAINING OF THE KEY ADHERENS JUNCTIONAL (AJ) PROTEIN ALPHAT-CATENIN (CTNNA3) IS COMPROMISED IN HUMAN BREAST CANCER. Abstract [Details]
Smith, JD,Meehan, M,McGoldrick, A,Harrison, M,McCormack, O,Dervan, P,Fitzpatrick, J,Kerin, M,McCann, A (2007) Alpha-T-catenin, a novel gene involved in cell adhesion, is structurally and epigenetically altered in breast cancer and not in lymph node deposits. Abstract [Details]
Mccann, A,O'Shea, DM,Fitzpatrick, P,O'Grady, A,Harrison, M,O'Kelly, P,Gilmartin, B,Watson, C,Beasley, A,Fitzpatrick, JM,Dervan, PA,Kay, EW (2007) Cytoplasmic E-cadherin (cdh1) staining is an independent predictor of time to recurrence in bladder cancer. Abstract [Details]
Clarke, T,Jenny, O,Fitzpatrick, JM,McCann, A (2007) Transcriptional regulation of E-cadherin (CDH1) in urothelial carcinoma of the bladder - the key players. Abstract [Details]
Shahbazi, RI,McCann, A,Frawley, A,Doran, P,Chung, WY,Dervan, P,Kerin, MJ (2004) Validation of gamma-actin as a potential target in breast cancer. Abstract [Details]
Balfe, P,McCann, A,McGoldrick, A,Kennedy, M,McAllister, K,Dervan, P,Kerin, MJ (2003) Antiestrogen therapy could be harmful in patients with oestrogen receptor-beta dominant tumours. Abstract [Details]
McGoldrick, A,McCann, A,Fitzpatrick, J,Smith, J,Dervan, PA (2002) Has bladder cancer MET its maker?. Abstract [Details]
McGoldrick, A,McCann, A,Fitzpatrick, J,Smith, J,Dervan, PA (2002) Microarray generated oncogene copy number profiling in human bladder cancer. Abstract [Details]
Greene, L. M., Twal, W. O., Maguire, T., McCann, A., Dervan, P., Duffy, M. J., Argraves, W. S., and Gallagher, W. M.; (2001) Proteolytic processing of fibulin-1 in human breast tumors is linked with estrogen receptor status. Abstract [Details]
Miller, N,McCann, A,O'Connell, D,Pedersen, IS,Spiers, V,Gorey, T,Dervan, PA (1998) Mono-allelic expression of the Mas proto-oncogene in human breast tissue. Abstract [Details]
McGarry, Y,Lewis, S,McCann, A,Moran, E,Sinha, SK,Kelehan, P,Dervan, P (1998) Distribution of the antigen recognised by the monoclonal antibody P1H10 in ovarian and breast tissue. Abstract [Details]
       

Reviews

McGrogan, BT,Gilmartin, B,Camey, DN,McCann, A (2008) Taxanes, microtubules and chemoresistant breast cancer. Reviews [DOI] [Details]
                                                   

Letters

Hosey, AM,Gorski, JJ,Quinn, JE,Chung, WY,Mccann, A,Harkin, DP (2008) Re: Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer - Response. Letters [DOI] [Details]
                       

Research

Research Interests

My group's specific area of interest is to decipher how cancer cells can maintain viability via cellular senescence in the face of chemotherapy,  particularly in the space of triple negative breast cancer and high grade serous ovarian cancer. Cellular senescence is a viable cellular fate mechanism which although non-replicative, is highly metabolically active producing a wealth of cytokines and an increased release of exosomes that  impact directly on the tumour microenvironment.  Tumour hypoxia integral to chemoresistance and indeed chemotherapeutic agents such as the taxanes and platinums used in the portfolio of drugs in the TNBC and ovarian cancer setting can also induce senescence.  We and others believe that the eradication of senescent cells will ensure a more efficacious patient response to chemotherapy.   

  • Breast Cancer
  • Bladder Cancer
  • Genomic Imprinting
  • DNA Methylation/Histone Acetylation
  • Microarray CGH

Identification Of EMT Related Markers As Indicators Of TCC Bladder Cancer

Recurrence Transitional cell carcinoma of the bladder (TCCB) inherently has a high risk of tumour recurrence associated with its biology.  Importantly, no reliable molecular marker is currently available to identify which TCCB patients are likely to develop metastatic disease.  In the scientific literature, there is much interest in the phenomenon of epithelial mesenchymal transition (EMT).  This describes the conversion from an epithelial to a mesenchymal phenotype, and is increasingly being considered as an important event in carcinoma progression and metastasis.  The increased invasive potential associated with EMT, coincides with loss of epithelial characteristics, and the acquisition of cells with an increased migratory and motile phenotype, allowing them to detach away from the parent tumour and move to distant sites.  As part of this EMT process, a number of proteins have been found to play a key role, identifying them therefore as candidate predictors of metastasis.  Little is known however about these proteins in TCC of the bladder.  Our overall hypothesis is that detection of EMT, either in the bladder tissue at the time of diagnosis, or in the patients¿ urine in subsequent follow up, will accurately predict the likelihood of bladder tumour recurrence, and thereby indicate the need for closer patient monitoring.  The development of an EMT urine test could result in an accurate non-invasive procedure to monitor TCC disease progression. 


Resistance To Microtubule Inhibitor (MI) Chemotherapy In Human Breast Cancer


In the advanced /metastatic breast cancer setting, there has been increased clinical use of microtubule inhibitors (MIs) such as Taxol® (paclitaxel), Taxotere® (docetaxel) and newer MIs such as Panzem® (2-ME2( 2-methoxyestradiol) in combinational chemotherapeutic regimes. 
However, breast cancer patients often have de novo resistance, or incomplete response to these MIs, even considering the fact that these agents constitute some of the most active agents for patients with this malignancy.  The mechanisms underlying this MI chemoresistance are currently unknown. 

In an effort to try and understand why certain breast tumours are refractory to these agents, we have undertaken a comprehensive analysis of two key effector molecules of the mitotic spindle assembly checkpoint MSC system, namely hsMAD1 and hsMAD2.  Our reasoning for investigating these molecules is as follows.  Microtubule inhibitors exert their affects on cellular mitosis through this spindle checkpoint MSC system.  This system is one of the main surveillance mechanisms censoring microtubule damage, the functionality of which hinges on the competency of hsMAD1 and hsMAD2.  When functioning properly, the MSC system ensures that the damage exerted on the microtubules by MIs is monitored, and therefore inhibits cells in proceeding to mitosis.  However, when the surveillance system is compromised, microtubule damage goes unchecked, and cells inappropriately complete the cell cycle.  It is therefore our hypothesis, that MAD1/MAD2 functionality is a prime candidate to help in identifying the sensitivity of breast cancer tumours to MI based chemotherapeutic regimes.  These are novel concepts and investigations for this tumour. 
 
UCD Medicine Research Theme: Translational Oncology 

Research Projects

Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : The Mater Foundation
Title : A multifaceted exploration of novel therapeutic options in Multiple Myeloma
Start Date / End Date : 01-SEP-15 / 31-AUG-17
Sponsor : University College Dublin (UCD)
Title : Dissemination of the research outputs of Mr. Luke Gubbins (BSc) (Third Year PhD) at the Keystone Symposia Conference "Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication (E4)"
Start Date / End Date : 01-APR-16 / 30-SEP-17
Sponsor : Health Research Board (HRB)
Title : Preventing chemotherapy resistance in triple negative breast cancer
Start Date / End Date : 01-OCT-14 / 30-SEP-17
Sponsor : Irish Research Council (IRC)
Title : Breast Surgery Recovery: The Clinical and Social Impact of the IsisRose Post Surgery Bra
Start Date / End Date : 01-MAR-15 / 28-FEB-17
Sponsor : University College Dublin (UCD)
Title : School funded research accounts - Amanda McCann
Start Date / End Date : 01-JUN-15 / 30-SEP-18
 

Current Postgraduate Students

Gordon Greville, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Claire Kelly, Master of Science (MSc)   -   Thesis Supervisor
Emma Kavanagh, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Leah Ewart, Doctor of Philosophy (PhD)   -   Thesis Co-Supervisor

Teaching

Teaching Philosophy

Modules Coordinated

201600   MDSA30290     Medicine Systems One: SSRA Research Elective II
201600   PATH30190     Pathology: Oncology & Immunopathology
201600   PATH30030     Pathology: Haematology/Immunosuppression
201600   MDSA30280     Medicine Systems One: SoM Research Elective II

Enhancement of Teaching

I have been a lecturer in the UCD School of Medicine and Medical Science (SMMS) since 1993, delivering material focusing on the Mechanisms of Disease specifically in the area of cancer biology, cancer genetics and epigenetics. A very good example of where I have had to specifically enhance my teaching skills is as follows. Graduate Entry Medicine (GEM) students unlike our undergraduate cohort, come to us with a First or a 21 Degree that could be in any discipline from Structural Engineering, to Spanish to Molecular Biochemistry. Bearing this in mind, Stage 1 GEM students take a Core 10 Credit Module called the Molecular Basis of Life and Disease (MBLD) PATH 20130, where I deliver material on cancer and cancer epigenetics. Therefore, I need to be sure that the material I deliver will bring all the students together at the same intellectual speed and engagement. In other words it is my upmost intention and remit to deliver this content in such a way that a student with a First in Spanish will be able to assimilate an understanding of the epigenetics material as well as or nearly as a student with a First in Molecular Biochemistry.

Review and Enhancement of Curriculum

Graduate Entry Medicine (GEM) students engage with a Core 10 Credit Module called the Molecular Basis of Life and Disease (MBLD PATH 20130) which I structured and co-ordinated from 2008-2010. Some of the educational enhancement in designing this module was as follows:-(1) The 56 MBLD lectures were themed around 7 overarching learning outcomes, paralleled by relevant Diseases as indicators of these learning outcomes. So for example, following the delivery of 5-6 basic biochemistry lectures detailing normal and aberrant glucose metabolism, I timetabled a Clinical Seminar to be given by Prof. Donal O Shea, Consultant Endocrinologist (SVUH) who would give the clinical aspects of treating a patient with altered glucose metabolism, in other words a patient with Diabetes. For this particular seminar, Donal brought a patient of his suffering from Type II diabetes who gave a real insight into the patient issues of living with this condition. I structured a total of 7 such clinical seminars, the format of which is still adopted in MBLD. (2) In addition, I introduced a novel form of assessment for this Module requiring that students submit group- work (2-3 Students per group) in the form of a lay-mans poster, suitable for display in a GPs Clinic or Hospital corridor. The stipulation for this submission was that the students designed a poster centred around one of the 7 central learning outcome using a specific disease to show evidence of their understanding of this particular learning outcome. So for example, lectures delivering content on the involvement of HPV and the development of Cervical Cancer, resulted in students designing a lay-mans poster describing the HPV etiology of Cervical Cancer but with the proviso that they did not use scientific jargon or potentially scare the reader.

Developing as a Teacher

One of the most enjoyable aspects of my role as an academic in UCDSMMS is teaching. Through the 20 years that I have engaged with our students coming through UCDSMM, I have always valued and encouraged student feedback. My philosophy in this regard is that student feedback once submitted, should be acted upon, and importantly should be seen to be acted upon by our students, ultimately to the enhancement of the student learning experience and the module learning outcomes as a whole. As an example, in taking over the Module coordination of the Stage 3 Oncology Immunopathology Module (PATH 30190) last year, I was keen to review the student feedback in relation to any constructive suggestions that would embellish the module educationally and from the learning experience for the students in the subsequent year. Specifically, students suggested that the module would benefit from a lecture on colorectal and lung cancer. In response to this I invited Professor Hugh Mulcahy, Consultant Gastroenterologist SVUH and Dr. Janice Walshe, Clinical Oncologist SVUH to deliver these lectures respectively. Verbal feedback from the current cohort of students has already been very positive to this new course material.