Navigation

Researchers at UCD

researcher

John Andrew Baugh

Associate Professor

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166729
Email: john.baugh@ucd.ie

Biography

My group is involved in several areas of translational medicine research with significant efforts to identify and commercialise novel serum biomarkers of heart failure and new therapeutics for fibro-inflammatory diseases such as heart failure with preserved ejection fraction (HFpEF)and idiopathic pulmonary fibrosis. We focus on understanding the nature of chronic fibrotic disease and are investigating the roles of inflammation, epigenetic modifications, and hypoxia in aberrant wound healing and the development of tissue fibrosis.

Professional

               

Education

Year 1999 Institution: University of Bath, UK
Qualification: PhD Subject:
Year 1995 Institution: University of Bath, UK
Qualification: BSc Subject:
         

Publications

 

Book Chapters

Li L. and Baugh JA (2012) 'Regulation of MIF Gene Expression in the Lung' In: Richard Bucala (eds). The MIF Handbook. Singapore: World Scientific Publishing. [Details]
J.A. Baugh; (2007) 'Gene Structure and Functional MIF Polymorphisms in Respiratory Disease' In: Richard Bucala (eds). MIF: A Most Interesting Factor. Singapore: World Scientific. [Details]
Donnelly SC and Baugh JA (2006) 'Macrophage Migration Inhibitory Factor' In: Geoffrey J. Laurent and Steven D. Shapiro (eds). Encyclopedia of Respiratory Medicine. UK: Elsevier. , pp.5-8 [Details]
Baugh J.A. and Donnelly S (2001) 'Macrophage Migration Inhibitory Factor (MIF) and Acute Lung Injury' In: S. Matalon and J.I. Sznajder (eds). Etiology and Treatment of Acute Lung Injury. New York: Plenum Press. , pp.151-157 [Details]
 

Peer Reviewed Journals

Watson C, James S;O'Connell E;Gallagher J;O'Reilly J;Tallon E;Baugh J;O'Connell J;O'Shea D;Ledwidge M;McDonald K (2016) 'Influence of diabetes on natriuretic peptide thresholds in screening for Stage B heart failure'. Biomarkers, :1-6. [DOI] [Details]
Becher PM, Jugdutt BI;Baugh J;Schmack B (2016) 'Experimental Heart Failure Models and Their Pathophysiological Characterization'. BioMed Research International, 2016 . [DOI] [Details]
Watson, CJ; Horgan, S; Neary, R; Glezeva, N; Tea, I; Corrigan, N; McDonald, K; Ledwidge, M; Baugh, J (2016) 'Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis'. Journal of Cardiovascular Pharmacology and Therapeutics, 21 (1):127-137. [Details]
Glezeva, N. and Voon, V. and Watson, C. and Horgan, S. and McDonald, K. and Ledwidge, M. and Baugh, J. (2015) 'Exaggerated inflammation and monocytosis associate with diastolic dysfunction in heart failure with preserved ejection fraction: Evidence of M2 macrophage activation in disease pathogenesis'. Journal of Cardiac Failure, 21 (2):167-177. Available Online [DOI] [Details]
Glezeva N, Horgan S;Baugh JA (2015) 'Monocyte and macrophage subsets along the continuum to heart failure: Misguided heroes or targetable villains?'. Journal of Molecular and Cellular Cardiology, 89 (Pt B):136-145. [DOI] [Details]
Horgan SJ, Watson CJ;Glezeva N;Collier P;Neary R;Tea IJ;Corrigan N;Ledwidge M;McDonald K;Baugh JA (2015) 'Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease'. Journal of Cardiovascular Translational Research, 8 (9):554-566. [DOI] [Details]
Neary R, Watson CJ;Baugh JA (2015) 'Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis'. Fibrogenesis and Tissue Repair, 8 . [DOI] [Details]
Dowling, D. and Corrigan, N. and Horgan, S. and Watson, C.J. and Baugh, J. and Downey, P. and McAuliffe, F.M. (2014) 'Cardiomyopathy in offspring of pregestational diabetic mouse pregnancy'. Journal of Diabetes Research, 2014 . Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Collier, P. and Horgan, S. and Glezeva, N. and Cooke, G. and Xu, M. and Ledwidge, M. and Mcdonald, K. and Baugh, J.A. (2014) 'Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta'. Connective Tissue Research, 55 (3):248-256. Available Online [DOI] [Details]
Watson, C.J. and Collier, P. and Tea, I. and Neary, R. and Watson, J.A. and Robinson, C. and Phelan, D. and Ledwidge, M.T. and Mcdonald, K.M. and Mccann, A. and Sharaf, O. and Baugh, J.A. (2014) 'Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype'. Human Molecular Genetics, 23 (8):2176-2188. Available Online [DOI] [Details]
Finucane OM, Reynolds CM, McGillicuddy FC, Harford KA, Morrison M, Baugh J,Roche HM (2014) 'Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis'. PLoS ONE, . [Details]
Horgan S, Watson C, Glezeva N, Baugh J (2014) 'Murine models of diastolic dysfunction and heart failure with preserved ejection fraction'. Journal of cardiac failure, . [Details]
Murtagh G, O Connell J, O Connell E, Tallon E, Watson C, Gallagher J, Baugh J, Patle A, O Connell L, Griffin J, O' Hanlon R, Voon V, Ledwidge M, O Shea D, McDonald K (2014) 'Importance of Risk Factor Management in Diabetic Patients & Reduction in Stage B Heart Failure'. Quarterly Journal of Medicine, . [Details]
Glezeva N, Baugh JA (2013) 'Role of inflammation in the pathogenesis of heart failure with preserved ejection fraction and its potential as a therapeutic target'. Heart Failure Reviews, Epub . Available Online [Details]
Glezeva, N. and Collier, P. and Voon, V. and Ledwidge, M. and McDonald, K. and Watson, C. and Baugh, J. (2013) 'Attenuation of monocyte chemotaxis-a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide'. Journal of Cardiovascular Translational Research, 6 (4):545-557. Available Online [DOI] [Details]
Jan, A. and Dawkins, I. and Murphy, N. and Collier, P. and Baugh, J. and Ledwidge, M. and McDonald, K. and Watson, C.J. (2013) 'Associates of an elevated natriuretic peptide level in stable heart failure patients: Implications for targeted management'. The Scientific World Journal, 2013 . Available Online [DOI] [Details]
Abulhul, E,McDonald, K,Martos, R,Phelan, D,Spiers, JP,Hennessy, M,Baugh, J,Watson, C,O'Loughlin, C,Ledwidge, M (2012) 'Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide'. Clinical Therapeutics, 34 :91-100. [DOI] [Details]
Collier, P. and Watson, C.J. and van Es, M.H. and Phelan, D. and McGorrian, C. and Tolan, M. and Ledwidge, M.T. and McDonald, K.M. and Baugh, J.A. (2012) 'Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype'. Journal of Molecular and Cellular Cardiology, 52 (1):148-153. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Xu, M. and Collier, P. and Neary, R. and Smolenski, A. and Ledwidge, M. and McDonald, K. and Baugh, J. (2012) 'Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: A possible defense against transforming growth factor-β mediated fibrosis'. Fibrogenesis and Tissue Repair, 5 (1). Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Waterhouse, D.F. and Dawkins, I.R. and Patle, A.K. and Horgan, S. and Conlon, C.M. and O'Hanlon, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K. (2012) 'Progression of left atrial volume index in a population at risk for heart failure: A substudy of the STOP-HF (St Vincent's Screening to Prevent Heart Failure) trial'. European Journal of Heart Failure, 14 (9):957-964. Available Online [DOI] [Details]
Phelan, D. and Watson, C. and Martos, R. and Collier, P. and Patle, A. and Donnelly, S. and Ledwidge, M. and Baugh, J. and McDonald, K. (2012) 'Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes'. PLoS ONE, 7 (11). Available Online [DOI] [Details]
Adamali, H., Armstrong, M. E., McLaughlin, A. M., Cooke, G., McKone, E., Costello, C. M., Gallagher, C. G., Leng, L., Baugh, J. A., Fingerle-Rowson, G., Bucala, R. J., McLoughlin, P., Donnelly, S. C. (2012) 'Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis'. American Journal of Respiratory and Critical Care Medicine, 186 (2):162-9. Available Online [DOI] [Details]
Robinson CM, Watson CJ, Baugh JA (2012) 'Epigenetics within the matrix: A neo-regulator of fibrotic disease'. Epigenetics, 7 (9):987-993. [DOI] [Details]
Robinson CM, Neary R, Levendale A, Watson CJ, Baugh JA (2012) 'Hypoxia-induced dna hypermethylation in human pulmonary fibroblasts is ssociated with thy-1 promoter methylation and the development of a pro-fibrotic Phenotype'. Respiratory Research, 13 (1). [DOI] [Details]
Watson, CJ,Ledwidge, MT,Phelan, D,Collier, P,Byrne, JC,Dunn, MJ,McDonald, KM,Baugh, JA; (2011) 'Proteomic Analysis of Coronary Sinus Serum Reveals Leucine-Rich alpha 2-Glycoprotein as a Novel Biomarker of Ventricular Dysfunction and Heart Failure'. Circulation: Heart Failure, 4 :188-126. [DOI] [Details]
Watson JA, Watson CJ, McCann A, Baugh J; (2010) 'Epigenetics, the epicenter of the hypoxic response'. Epigenetics : official journal of the DNA Methylation Society, 5 (4):293-296. [Details]
Martos, R,Baugh, J,Ledwidge, M,O'Loughlin, C,Murphy, NF,Conlon, C,Patle, A,Donnelly, SC,McDonald, K; (2009) 'Diagnosis of heart failure with preserved ejection fraction: improved accuracy with the use of markers of collagen turnover'. European Journal of Heart Failure, 11 :191-197. [DOI] [Details]
Mak, GJ,Ledwidge, MT,Watson, CJ,Phelan, DM,Dawkins, IR,Murphy, NF,Patle, AK,Baugh, JA,McDonald, KM; (2009) 'Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone'. Journal of the American College of Cardiology, 54 :1674-1682. [DOI] [Details]
Baugh JA, Byrne JD, ; (2008) 'The significance of nanoparticles in particle-induced pulmonary fibrosis'. McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students, 11 (1):43-50. [Details]
Armstrong, M. E., Gantier, M., Li, L. L., Chung, W. Y., McCann, A., Baugh, J. A., Donnelly, S. C., ; (2008) 'Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism'. Immunology, 180 (11):7125-7133. [Details]
Kevill, K. A., Bhandari, V., Kettunen, M., Leng, L., Fan, J., Mizue, Y., Dzuira, J. D., Reyes-Mugica, M., McDonald, C. L., Baugh, J. A., O'Connor, C. L., Aghai, Z. H., Donnelly, S. C., Bazzy-Asaad, A., Bucala, R. J., ; (2008) 'A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome'. Immunology, 180 (1):601-608. [Details]
Govender, P.,Baugh, J. A.,Pennington, S. R.,Dunn, M. J.,Donnelly, S. C.; (2007) 'Role of proteomics in the investigation of pulmonary fibrosis'. Expert Rev Proteomics, 4 (3):379-88. Available Online [Details]
Plant, BJ; Ghani, S; O'Mahony, MJ; Morgan, L; O'Connor, CM; Morgan, K; Baugh, JA; Donnelly, SC; ; (2007) 'Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population'. European Respiratory Journal, 29 (2):325-329. [Details]
Gantier, MP,Baugh, JA,Donnelly, SC; (2007) 'Nuclear transcription of long hairpin RNA triggers innate immune responses'. Journal of Interferon Cytokine Research, 27 :789-797. [DOI] [Details]
Baugh, JA,Gantier, M,Li, L,Byrne, A,Buckley, A,Donnelly, SC; (2006) 'Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1'. Biochemical and Biophysical Research Communications, 347 :895-903. [DOI] [Details]
Martos, R; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; ; (2006) 'Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure'. European Heart Journal, 27 (NA):844-844. [Details]
Martos, R; Patle, A; Baugh, J; Ledwidge, M; Loughlin, CO; Conlon, C; Donnelly, S; Mc Donald, K; ; (2006) 'The role of myocardial fibrotic markers in detecting different stages of diastolic dysfunction in a hypertensive population'. European Heart Journal, 27 (NA):300-300. [Details]
Martos, R; Baugh, J; O'Loughlin, C; Ledwidge, M; Donnelly, S; McDonald, K; ; (2005) 'Diastolic heart failure is associated with elevated serum markers of collagen turnover'. European Heart Journal, 26 (NA):602-602. [Details]
Mizue, Y; Ghani, S; Leng, L; McDonald, C; Kong, P; Baugh, J; Lane, SJ; Craft, J; Nishihira, J; Donnelly, SC; Zhu, Z; Bucala, R; ; (2005) 'Role for macrophage migration inhibitory factor in asthma'. Proceedings of the National Academy of Sciences of the United States of America, 102 (40):14410-14415. [Details]
Plant, BJ; Gallagher, CG; Bucala, R; Baugh, JA; Chappell, S; Morgan, L; O'Connor, CM; Morgan, K; Donnelly, SC; ; (2005) 'Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism'. American Journal of Respiratory and Critical Care Medicine, 172 (11):1412-1415. [Details]
Plant, BJ; Baugh, JA; Chappell, S; Morgan, L; Keatings, V; O'Connor, C; Morgan, K; Donnelly, SC; ; (2004) 'The role of a macrophage migration inhibitory factor (MIF) functional polymorphism in chronic obstructive pulmonary disease'. Thorax, 59 (1):69-69. [Details]
Geall, AJ; Baugh, JA; Loyevsky, M; Gordeuk, VR; Al-Abed, Y; Bucala, R; ; (2004) 'Targeting malaria with polyamines'. Bioconjugate Chemistry, 15 (6):1161-1165. [Details]
Leng, L; Metz, CN; Fang, Y; Xu, J; Donnelly, S; Baugh, J; Delohery, T; Chen, YB; Mitchell, RA; Bucala, R; ; (2003) 'MIF signal transduction initiated by binding to CD74'. Experimental Medicine, 197 (11):1467-1476. [Details]
Pan JH, Lindholt JS, Sukhova GK, Baugh JA, Henneberg EW, Bucala R, Donnelly SC, Libby P, Metz C, Shi GP. ; (2003) 'Macrophage migration inhibitory factor is associated with aneurysmal expansion'. Journal of Vascular Surgery, 37 (3):628-635. [Details]
Baugh, JA; Donnelly, SC; ; (2003) 'Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation'. Journal of Endocrinology, 179 (1):15-23. [Details]
Baugh JA, Chitnis S, Donnelly SC, Monteiro J, Lin X, Plant BJ, Wolfe F, Gregersen PK, Bucala R. ; (2002) 'A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis'. Genes and Immunity, 3 (3):170-176. [Details]
O'Reilly, KMA; Baugh, JA; Plant, BJ; Fitzgerald, MX; Bucala, R; Donnelly, SC; ; (2002) 'Macrophage Migration Inhibitory Factor induces proliferation and has pro-fibrotic effects in primary human pulmonary fibroblasts'. Thorax, 57 (NA). [Details]
Baugh JA, Bucala R. ; (2001) 'Mechanisms for modulating TNF alpha in immune and inflammatory disease'. Current Opinion in Drug Discovery and Development, 4 (5):635-650. [Details]

Other Journals

Byrne JD, Baugh JA; (2008) 'The significance of nanoparticles in particle-induced pulmonary fibrosis' McGill Journal of Medicine 11 (1) :43-50. [Details]

Conference Publications

Adamali HI, Baugh J, Fingerle-Rowson G, McLoughlin P, Donnelly SC; (2008) Enzymatic actvity of macrophage inhibitory factor (MIF) regulates growth of pseudomonas aeruginosa (Pa): implications for therapeutic interventions in cystic fibrosis American Thoracic Society International Conference [Details]
Phelan, D, Watson, CJ, Donnelly, S, Ledwidge, M, Baugh, J, Mcdonald, K, ; (2007) EUR J HEART FAIL Transforming growth factor beta induces collagen type I and alpha smooth muscle actin production in human cardiac fibroblasts , pp.101-101 [Details]
Watson, CJ, Phelan, DMJ, Ledwidge, M, Donnelly, S, Mcdonald, K, Baugh, J, ; (2007) EUR J HEART FAIL Increased MMP2 activity following treatment of cardiac fibroblast with Angiotensin II, Alclosterone, Endothelin-1 and TGF beta , pp.101-101 [Details]
Li, L., Byrne, A., O'Reilly, K.M.A., Donnelly S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factory (MFI) is an early growth response-1 (EGR-1) target gene in TGFb activated human lung fibroblasts American Thoracic Society [Details]
Li, L., O'Reilly, KMA., Buckley, A., Byrne, A.B., McLaughlin, A.M., Kettunen, M.P, Govender, P., Baugh, J.A., Donnelly, S.C.; (2006) Sarcoidosis Bronchoalveolar Lavage (BAL) Fluid Induces the Differentiation of Normal Human Primary Lung Fibroblasts into Myofibroblasts American Thoracic Society [Details]
Kettunen, M., Brennan, L., Govender, P., Newsholme, P., Baugh, J.A. Donnelly S.C.; (2006) 1H NMR Analysis of BAL Fluid as a Potential Prognostic Tool in Sarcoidosis American Thoracic Society [Details]
Byrne, A., Li, L., Gantier, M., Buckley, A., O'Reilly, K., Donnelly, S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factor (MIF): A Hypoxia Regulated Mediator of Pulmonary Fibrosis Hypoxia and Development, Physiology and Disease (Keystone) [Details]
Li, L., Byrne, A., O'Reilly, K.M.A., Donnelly S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factory (MFI) is an early growth response-1 (EGR-1) target gene in TGFb activated human lung fibroblasts American Thoracic Society [Details]
Li, L., O'Reilly, KMA., Buckley, A., Byrne, A.B., McLaughlin, A.M., Kettunen, M.P, Govender, P., Baugh, J.A., Donnelly, S.C.; (2006) Sarcoidosis Bronchoalveolar Lavage (BAL) Fluid Induces the Differentiation of Normal Human Primary Lung Fibroblasts into Myofibroblasts American Thoracic Society [Details]
Byrne, A., Li, L., Gantier, M., Buckley, A., O'Reilly, K., Donnelly, S.C. Baugh, J.A.; (2006) Macrophage Migration Inhibitory Factor (MIF): A Hypoxia Regulated Mediator of Pulmonary Fibrosis Hypoxia and Development, Physiology and Disease (Keystone) [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Conlon, C., Donnelly, S. McDonald, K.; (2006) Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure Heart Failure Congress [Details]
Byrne, A., Li, L., Gantier, M., Donnelly, S.C. Baugh, J.A.; (2006) Hypoxia-Induced Fibroroliferation is Rho Dependent and Augmented by Macrophage Migration Inhibitory Factor (MIF) American Thoracic Society [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover World Congress of Cardiology [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover Heart Failure Congress [Details]
Martos, R., Baugh, J., Ledwidge, M., Patle, A., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Brain natriuretic peptide levels correlate with indices of diastolic function and serum markers of increased collagen turnover Irish Cardiac Society [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover Irish Cardiac Society [Details]
                       

Abstract

Horgan, S,Watson, C,Collier, P,Ledwidge, M,McDonald, K,Baugh, J (2012) Diabetic Hearts Show Increased Lysyl Oxidase Expression. Abstract [Details]
Watson, C,Collier, P,Horgan, S,Conlon, C,O'Hanlon, R,Ledwidge, M,Baugh, J,McDonald, K (2012) Identification of Serum Biomarkers that Reflect Progressive Cardiac Remodelling. Abstract [Details]
Glezeva, N,Voon, V,Watson, C,Ledwidge, M,McDonald, K,Baugh, J (2012) Patients with Hypertension and Heart Failure with Preserved Ejection Fraction Present with Elevated Inflammatory and Alternative Monocyte/Macrophage-Apecific Markers in their Peripheral Circulation. Abstract [Details]
Horgan, S,Watson, C,Collier, P,Ledwidge, M,McDonald, K,Baugh, J (2012) A Novel Biomarker and Potential Treatment for Diastolic Dysfunction and Heart Failure. Abstract [Details]
Watson, C,Neary, R,Collier, P,Tolan, M,Ledwidge, M,McDonald, K,Baugh, J (2012) Myocardial Tissue Hypoxia is Associated with Changes in the Epigenome. Abstract [Details]
Bates, A,Watson, C,Baugh, J (2011) ROLE OF SERUM AMYLOID P IN FIBROSIS AND DIASTOLIC HEART FAILURE. Abstract [Details]
Phelan, D,Watson, C,Collier, P,Ledwidge, M,Baugh, J,McDonald, K (2011) STRETCHED INDUCED B-TYPE NATRIURETIC PEPTIDE ALTERS HUMAN CARDIAC FIBROBLAST RESPONSE TO TRANSFORMING GROWTH FACTOR BETA AND MAY BE PROTECTIVE AGAINST MYOCARDIAL FIBROSIS. Abstract [Details]
Tea, I,Robinson, C,Watson, C,Baugh, J (2011) IDENTIFICATION OF A FUNCTIONAL HYPOXIA RESPONSE ELEMENT IN THE PROMOTER REGION OF THE DNA METHYLTRANSFERASE 3B GENE; POTENTIAL ROLE IN INFLAMMATORY, FIBROTIC & MALIGNANT DISEASE. Abstract [Details]
Nelligan, N,Dubourd, M,Robinson, C,Watson, C,Baugh, J (2010) HYPOXIA INHIBITS RNA METHYLTRANSFERASE NSUN2 EXPRESSION IN PRIMARY HUMAN AIRWAY EPITHELIA; AND THE DEVELOPMENT OF A NOVEL ANALYTICAL TECHNIQUE TO ELUCIDATE THE POTENTIAL ROLE OF HYPOXIA IN REGULATING GLOBAL RNA METHYLATION. Abstract [Details]
Glezeva, N,Collier, P,Watson, C,Ledwidge, M,McDonald, K,Baugh, J (2010) ATTENUATION OF MONOCYTE CHEMOTAXIS-A NOVEL ANTI-INFLAMMATORY MECHANISM OF ACTION FOR THE CARDIOPROTECTIVE HORMONE B-TYPE NATRIURETIC PEPTIDE. Abstract [Details]
Mak, G,Murphy, NF,Phelan, D,Watson, C,O' Loughlin, C,Baugh, J,Ledwidge, M,Mc Donald, K (2008) The effects of low dose eplerenone on markers of collagen turnover in diastolic heart failure. Abstract [Details]
Martos, R,Baugh, J,Ledwidge, M,Oloughlin, C,Murphy, N,Conlon, C,Donnelly, S,Mcdonald, K (2008) Diagnosis of diastolic heart failure: improved accuracy with use of markers of collagen turnover. Abstract [Details]
Watson, CJ,Phelan, DMJ,Ledwidge, M,Donnelly, S,Mcdonald, K,Baugh, J,Phelan, DMJ (2007) Increased MMP2 activity following treatment of cardiac fibroblast with Angiotensin II, Alclosterone, Endothelin-1 and TGF beta. Abstract [Details]
Phelan, D,Watson, CJ,Donnelly, S,Ledwidge, M,Baugh, J,Mcdonald, K (2007) Transforming growth factor beta induces collagen type I and alpha smooth muscle actin production in human cardiac fibroblasts. Abstract [Details]
Martos, R,Patle, A,Baugh, J,Ledwidge, M,Loughlin, CO,Conlon, C,Donnelly, S,Mc Donald, K (2006) The role of myocardial fibrotic markers in detecting different stages of diastolic dysfunction in a hypertensive population. Abstract [Details]
Martos, R,Baugh, J,Ledwidge, M,Loughlin, CO,Conlon, C,Donnelly, S,Mc Donald, K (2006) Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure. Abstract [Details]
Martos, R,Baugh, J,O'Loughlin, C,Ledwidge, M,Donnelly, S,McDonald, K (2005) Diastolic heart failure is associated with elevated serum markers of collagen turnover. Abstract [Details]
                                                                                       

Research

Research Interests

Background

My research group is interested in the mechanisms involved in the onset and progression of aberrant tissue remodelling in inflammatory lung and cardiac diseases. In particular, we are trying to elucidate the mechanisms that control inflammatory cell function, fibroblast activation, and myocyte hypertrophy in patients suffering from heart failure with preserved ejection fraction (HFpEF)

Disease progression in HFpEF is associated with inflammation and fibrosis that leads to reduced compliance (increased stiffness) of the left ventricular and the development of diastolic dysfunction.  Vascular injury leads to the recruitment of inflammatory cells to the heart, that cause tissue damage and trigger the wound healing process.  Exaggerated wound healing manifests as fibrosis.  Tissue fibrosis and reduced microvascular density likely leads to the development of tissue hypoxia and a viscous cycle that leads to organ failure. 

The main drivers of HFpEF are hypertension, obesity, and diabetes.  The objective of my research is to gain a greater understanding of how these conditions promote and exaggerated inflammatory response that causes heart failure.


Ongoing Projects

  1. Repurposing of 5-azacytidine for the treatment of hypertrophic cardiomyopathy (EpiCor Therapeutics).
  2. Role of diet and gut microbiota in regulating systemic inflammation in the setting of heart failure.
  3. Epigenetic regulation of inflammatory cell function in heart failure.
  4. Role of dysregulated angiongenesis in HFpEF.


FUNDING AGENCIES: 
SFI-STAR
HRB
HRB Equipment
IRCSET
Irish Lung Foundation

Research Projects

Sponsor : Health Research Board (HRB)
Title : Natural History of Diabetic Cardiomyopathy
Start Date / End Date : 01-DEC-12 / 30-NOV-17
Sponsor : Health Research Board (HRB)
Title : Immunomodulatory-matrix metalloproteinase (MMP) inhibition with tetracyclines in obesity, diabetes and asymptomatic left ventricular diastolic dysfunction: impact on MMP-9 levels and cardiovascular structure and function
Start Date / End Date : 01-NOV-12 / 31-DEC-16
Sponsor : Enterprise Ireland (EI)
Title : Epigenetic therapy for the treatment of hypertrophic cardiomyopathies
Start Date / End Date : 18-AUG-14 / 17-AUG-15
Sponsor : University College Dublin (UCD)
Title : Epigenetic Control of Inflammatory Cell Phenotype in Heart Failure
Start Date / End Date : 01-APR-15 / 31-MAR-17
Sponsor : Irish Heart Foundation
Title : The role of Serum Amyloid P-Component in the prevention and treatment of diastolic dysfunction and diastolic heart failure
Start Date / End Date : 01-JUL-10 / 30-JUN-12
Sponsor : Irish Cardiac Society (ICS)
Title : Boston Scientific Research Bursary
Start Date / End Date : 01-SEP-10 / 01-SEP-12
Sponsor : Health Research Board (HRB)
Title : The role of Serum Amyloid P-Component in the prevention and treatment of diastolic dysfunction and diastolic heart failure.
Start Date / End Date : 01-JUL-11 / 30-JUN-13
Sponsor : Health Research Board (HRB)
Title : Biomarkers for the prevention of heart failure
Start Date / End Date : 01-OCT-11 / 30-SEP-14
Sponsor : University College Dublin (UCD)
Title : 5'-azacytidine as a novel treatment for Idiopathic Pulmonary Fibrosis
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Enterprise Ireland (EI)
Title : Biomarkers of heart Failure and Cardiovascular Disease
Start Date / End Date : 01-APR-12 / 31-MAR-13
Sponsor : University College Dublin (UCD)
Title : Biomarkers for the Prevention of Heart Failure
Start Date / End Date : 17-MAY-10 / 16-NOV-11
Sponsor : University College Dublin (UCD)
Title : Attendance of European Respiratory Society Annual Congress 2009
Start Date / End Date : 03-AUG-09 / 31-JAN-11
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Role of b-type Natriuretic Peptide (BNP) in the development of Diastolic Heart Failure
Start Date / End Date : 01-OCT-08 / 30-SEP-11
Sponsor : University College Dublin (UCD)
Title : Role of EMT in Cardiac Fibrosis;
Start Date / End Date : 01-JUL-08 / 30-JUN-09
Sponsor : HEA/PRTLI Cycle 4 Grant
Title : Biomedical Sciences Network
Start Date / End Date : 01-JUL-08 / 30-JUN-11
Sponsor : University College Dublin (UCD)
Title : In vivo models of hypoxic lung disease
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Science Foundation Ireland (SFI)
Title : The role of macrophage migration inhibitory factor (MIF) in aberrant pulmonary vascular remodelling and the pathogenesis of hypoxic pulmonary hypertension
Start Date / End Date : 01-MAY-07 / 31-OCT-10
Sponsor : A. Menarini Pharmaceuticals Ireland Ltd.
Title : Prevention of Heart Failure
Start Date / End Date : 11-AUG-06 / 10-AUG-08
Sponsor : The Heartbeat Trust
Title : Role of Myoxardial Fibrosis in Diastolic Dysfunction
Start Date / End Date : 01-JUL-06 / 31-JUL-12
Sponsor : Science Foundation Ireland (SFI)
Title : Live cell imaging of lung cell transformation when deprived of oxygen
Start Date / End Date : 01-JUN-05 / 31-AUG-05
Sponsor : Health Research Board (HRB)
Title : Regulation of Macrophage Migration Inhibitory Factor Expression
Start Date / End Date : 01-OCT-04 / 30-SEP-07
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Hypoxic regulation of macrophage migration inhibitory factor and its role in fibroproliferation
Start Date / End Date : 01-OCT-04 / 30-SEP-07
Sponsor : Irish Lung Foundation
Title : Human MIF promoter polymorphisms and chronic Inflammatory Lung Disease
Start Date / End Date : 01-DEC-03 / 31-DEC-04
Sponsor : Health Research Board (HRB)
Title : Hypoxic regulation of airway epithelial injury and EMT in pulmonary fibrosis
Start Date / End Date : 01-OCT-06 / 30-SEP-09
Sponsor : Irish Lung Foundation
Title : The role of Hypoxia in the progression of pulmonary fibrosis
Start Date / End Date : 01-SEP-06 / 31-AUG-07
   

Teaching

Teaching Philosophy

In summary, my teaching philosophy is to utilise student-centered learning wherever possible in order to stimulate interest and maintain student attention.
 

Enhancement of Teaching

PHYS20050 (320 students stage 2 Medicine) Given the diversity of my audience, and the appreciation that not all students do well in classical large lecture theatre situations, I use as many animations/videos/graphics as possible. In this way I hope that I can stimulate the interest of my students and maintain their attention. In response to student feedback I have also introduced small group tutorials. Annual review of my curriculum and grade distributions with my colleagues and our external examiner, as well as analysis of essay responses, has helped me refine my module content and level, and assessment structure. Peer mentoring from colleagues (Dr. Amanda McCann, Dr. Stuart Bund) has encouraged me that I am good at explaining complex concepts but warned me that I often include too much information. I try to play to my strengths whilst reducing the content of my lectures. I believe it is better that the students understand the concepts than become overloaded with information. PHYS30190 (25 students Stage 3 Science) I have made a significant effort to improve student understanding of the principles of research by developing a new experimental physiology module. This module allows one-on-one practical tuition which improves student¿s ability to fully engage with fourth year research projects and graduate as effective Physiologists. By challenging students in a research environment I encourage independent learning and critical thinking. In response to student feedback I have now supplemented this intensive laboratory-based module with weekly tutorials that focus more on theory and presentation/communication skills.

Review and Enhancement of Curriculum

As PHYS20050 is a diverse module it is crucial that it is integrated within the medicine curriculum. Over the last year I have altered content to integrate with the parallel biochemistry module (Molecules in medicine) and extensively reviewed the immunology content of the medicine curriculum with Dr. Clare O¿Connor, Dr. Helen Gallagher. We have now restructured the immunology content of three modules, including PHYS20050, to allow a progressive development in content and eliminate duplication of material. During this process the learning objectives of all modules were clarified and the level of content in both modules more closely aligned with the stage expectations. PHYS20050 is now designed to complement large class lectures with smaller computer-aided learning sessions and parallel small group tutorials. Tutorial sessions are complemented with online interactive simulations/tutorials. Student progress is assessed via a true/false MCQ. The content of later tutorials is guided by the MCQ results and final assessment is in the form of best of five MCQ that tests depth and breadth of knowledge. Module Development Two of the main strengths I bring to UCD are my background in molecular and cellular biology, and my translational medicine research activity. When I started supervising fourth year Physiology research students I was struck by their lack of practical experience. In an attempt to address this and increase their knowledge of modern molecular physiology I have developed a stage 3 experimental module (PHYS30190) which is designed to help students become proficient in experimental design, problem solving, team work, and scientific writing. This is achieved by working with students in the laboratory and challenging them to run experiments, collect data and write full reports. After three years running this module it is apparent that when these students enter fourth year they

Developing as a Teacher

A significant driver of my development as a teacher is student feedback and peer mentoring. I find that anonymous student feedback and grading essay papers are the best way of highlighting what I am doing wrong (and right) as a lecturer. I always discuss feedback with senior colleagues in order to learn from their experience. In addition I actively engage with my Physiology colleagues at monthly staff meetings and end of semester exam review boards in order to keep up to date with best practise in teaching and assessment, and curriculum design. I keep up to date with my subject area by regularly attending and presenting at conferences. At a programme level I have attended several School of Medicine Teaching and Learning workshops and have been involved in curriculum review and module mapping. As a Mentor I have been involved in training twenty Demonstrators and several Post-doctoral Fellows in the area of small group teaching. Teaching them how to better engage with students and enhance learning on my modules has forced me to interrogate and enhance my own methods of teaching.

Innovation & Leadership

My most significant contributions to innovation and leadership in teaching and learning have come in the area of Post-graduate education. In this area I have played a significant role in developing and implementing the Translational Medicine PhD programme in UCD and improving the quality of PhD graduates across the School of Medicine and Medical Science.

Collaborators

Internal Collaborators

Ken McDonald
Mark Ledgwidge
Robert Mitchell
Seamas Donnelly
Kate O'Reilly
Dr. Chris Watson chris.watson@ucd.ie - Epigenetics therapies and biomarker discovery
Dr. Nadezhda Glezeva nadezhda.glezeva.ucd.ie - Inflammation in Heart Failure