Navigation

Researchers at UCD

Padraig MacMathuna

School of Medicine & Medical Science

Tel:
Email: pmacmathuna@mater.ie

Biography

1981 UCD graduate with training in Ireland, London and Boston in Gastroenterology. Appointed Consultant Gastroenterologist to Mater University Hospital in 1995.  Track record in clinical and laboratory research in areas from Colon Cancer biology, CT Colon Imaging, High Risk colorectal Cancer screening and endoscopic intervention. Research grant funding from  Irish Cancer Society, HRB and SFI. Recently appointed Associate Professor of Medicine in recognition of contribution to the postgraduate (Former Postgraduate Dean) and undergraduate academic activity of the Mater and UCD. Currently a member of the NCSS Advisory group on Colorectal Cancer Screening and a participant in the NCSS Expert Group on Herediary Cancer Risk. 

Publications

     

Peer Reviewed Journals

Leyden JE, Moss AC;MacMathuna P (2015) 'Endoscopic pneumatic dilation versus botulinum toxin injection in the management of primary achalasia'. Cochrane Database of Systematic Reviews, 12 . [DOI] [Details]
Coleman C, Quinn EM;Ryan AW;Conroy J;Trimble V;Mahmud N;Kennedy N;Corvin AP;Morris DW;Donohoe G;O'Morain C;MacMathuna P;Byrnes V;Kiat C;Trynka G;Wijmenga C;Kelleher D;Ennis S;Anney RJ;McManus R (2015) 'Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci'. European Journal of Human Genetics, . [DOI] [Details]
Lahiff C, Cotter E;Casey R;Doran P;Pidgeon G;Reynolds J;Macmathuna P;Murray D (2013) 'Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype'. Journal of Experimental and Clinical Cancer Research, 32 (1). [DOI] [Details]
Lahiff C, Schilling C;Cathcart MC;Mulligan N;Doran P;Muldoon C;Murray D;Pidgeon GP;Reynolds JV;Macmathuna P (2013) 'Prognostic significance of neuroepithelial transforming gene 1 in adenocarcinoma of the oesophagogastric junction'. British Journal of Surgery, 101 (2):55-62. [DOI] [Details]
Zaheer A, Anwar MM;Donohoe C;O'Keeffe S;Mushtaq H;Kelleher B;Clarke E;Kirca M;McKiernan S;Mahmud N;Keeling N;MacMathuna P;O'Toole D (2013) 'The diagnostic accuracy of endoscopic ultrasound in suspected biliary obstruction and its impact on endoscopic retrograde cholangiopancreatography burden in real clinical practice: a consecutive analysis'. European Journal of Gastroenterology and Hepatology, 25 (7):850-857. [DOI] [Details]
Bennett G, Sadlier D, Doran PP, Macmathuna P, Murray DW; (2011) 'A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer'. BMC Cancer, 11 . [DOI] [Details]
Brophy K, Ryan AW, Turner G, Trimble V, Patel KD, O'Morain C, Kennedy NP, Egan B, Close E, Lawlor G, MacMathuna P, Stevens FM, Abuzakouk M, Feighery C, Kelleher D, McManus R (2010) 'Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study'. BMC Medical Genetics, 11 . [DOI] [Details]
Lawlor G, Doran PP, MacMathuna P, Murray DW; (2010) 'MYEOV (myeloma overexpressed gene) drives colon cancer cell migration and is regulated by PGE2'. Clinical Cancer Research, 29 . [DOI] [Details]
Adány R, Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA (2010) 'Multiple common variants for celiac disease influencing immune gene expression'. Nature Genetics, 42 (4):295-302. [DOI] [Details]
Bennett, G.Bennett, G.,Murray, D. W.Murray, D. W.,Mac Mathuna, P.Mac Mathuna, P.,Doran, P.Doran, P.; (2009) 'NET1: A Potent Promoter of Gastric Cancer - Characterisation of Gene Expression Profile Using a Novel Gene Knockdown Model'. GastroenterologyGastroenterologyGastroenterology, 136 (55). Available Online [Details]
Harewood G, Byrne S, Clarke E, Lennon J, MacMathuna P, Coss A, O'Donovan D, ; (2009) 'Knowledge of the indications for endoscopic ultrasound (EUS) among gastroenterologists and non-gastroenterologists'. Irish Medical Journal, 102 (2):50-52. [Details]
Anquetin, G., Horgan, G., Rawe, S., Murray, D., Madden, A., MacMathuna, P., Doran, P., Murphy, P. V., ; (2008) 'Synthesis of novel macrolactam and macroketone analogues of migrastatin from D-glucal and comparison with macrolactone and acyclic analogues: A dorrigocin A congener is a potent inhibitor of gastric cancer cell migration'. European Journal of Organic Chemistry, (11):1953-1958. [Details]
Doran P, Murray D, Horgan G, Macmathuna P, ; (2008) 'NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer'. British Journal of Cancer, 8 (NA):1322-1329. [DOI] [Details]
Horgan, G., Murray, D., Madden, A., Bennett, G., Anquetin, G., Murphy, P., Lennon, J., MacMathuna, P., Doran, P., ; (2008) 'Gastric cancer cell migration is reduced by novel migrastatin analogues'. Gut, 57 :23-24. [Details]
Murray, D. W.Murray, D. W.,Macmathuna, P.Macmathuna, P.,Doran, P.Doran, P.; (2007) 'Netl, a novel gastric adenocarcinoma-associated gene, drives tumor migration and invasion via cytoskeletal rearrangement events'. GastroenterologyGastroenterologyGastroenterology, 132 (44). Available Online [Details]
Murray, D.,Doran, P.,MacMathuna, P.,Moss, A. C.; (2007) 'In silico gene expression analysis--an overview'. Mol Cancer, 6 :50. [Details]
Moss, A. C.,Morris, E.,Leyden, J.,Macmathuna, P.; (2007) 'Do the benefits of metal stents justify the costs? A systematic review and meta-analysis of trials comparing endoscopic stents for malignant biliary obstruction'. Eur J Gastroenterol Hepatol, 19 (12):1119-24. [Details]
Moss, A. C.,Morris, E.,Leyden, J.,MacMathuna, P.; (2007) 'Malignant distal biliary obstruction: a systematic review and meta-analysis of endoscopic and surgical bypass results'. Cancer Treat Rev, 33 (2):213-21. [Details]
Moss AC, Murray D, Doran P, MacMathuna P, ; (2007) 'In silico gene expression analysis--an overview'. Journal of Cancer, 6 . [DOI] [Details]
Madden A, Murray D, Murphy PV, Anquetin G, MacMathuna P and Doran P; (2007) 'Novel Migrastatin Analogues and Gastric Cancer Cell Migration'. IRISH JOURNAL OF MEDICAL SCIENCE, 176 (13):498. [Details]
Canny, G; Drudy, D; MacMathuna, P; O'Farrelly, C; Baird, AW; ; (2006) 'Toxigenic C-difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical'. Life Sciences, 78 (9):920-925. [Details]
Leyden, J. E.,Moss, A. C.,MacMathuna, P.; (2006) 'Endoscopic pneumatic dilation versus botulinum toxin injection in the management of primary achalasia'. Cochrane Database Syst Rev, (4):CD005046. [Details]
Gleeson, F.,Clarke, E.,Lennon, J.,MacMathuna, R.,Crowe, J.; (2006) 'Outcome of accident and emergency room triaged patients with low risk non-variceal upper gastrointestinal haemorrhage'. Ir Med J, 99 (4):114-7. [Details]
Moss AC, Morris E, Mac Mathuna P.; (2006) 'Palliative biliary stents for obstructing pancreatic carcinoma'. Cochrane Database of Systematic Reviews, . [Details]
Moss AC and Lawlor G, Murray D, Tighe D, Madden SF, Mulligan AM, Keane CO, Brady HR, Doran PP and MacMathuna P ; (2006) 'ETV4 and Myeov knockdown impairs colon cancer cell line proliferation and invasion'. Biochemical and biophysical research communications, 345 (1):216-221. [DOI] [Details]
Murray, D. W.Murray, D. W.,Leyden, J.Leyden, J.,McEntee, G.McEntee, G.,O'Keane, C.O'Keane, C.,MacMathuna, P.MacMathuna, P.,Doran, P.Doran, P.; (2006) 'NET1 - A novel activator of RhoA and gastric cancer cell invasion'. GastroenterologyGastroenterologyGastroenterology, 130 (44). Available Online [Details]
Lowlor, G.Lowlor, G.,Moss, A.Moss, A.,Tighe, D.Tighe, D.,Murray, D. W.Murray, D. W.,O'Keane, C.O'Keane, C.,Doran, P.Doran, P.,MacMathuna, P.MacMathuna, P.; (2006) 'Functional significance of enhanced ETV4 and MYEOV expression in colorectal neoplasia using sirna-mediated gene knockdown'. GastroenterologyGastroenterologyGastroenterology, 130 (44). Available Online [Details]
Leyden, J; Murray, D; Moss, A; Arumuguma, M; Doyle, E; McEntee, G; O'Keane, C; Doran, P; MacMathuna, P; ; (2006) 'Net1 and Myeov: computationally identified mediators of gastric cancer'. British Journal of Cancer, 94 (8):1204-1212. [Details]
Barry, J. Bourke, M. Buckley, M. Coughlan, B. Crowley, D. Cullen, W. Dooley, S. Keating, S. Kelleher, D. Moloney, J. Murray, F. McCormack, PA. MacMathuna, P. O' Connor, J. O' Grady, J. O'Sullivan, C. O'Sullivan, P. Quinn, C. Smyth, B. Sweeney, B.; ; (2004) 'Hepatitis C among drug users: consensus guidelines on management in general practice'. Irish Journal of Medical Science, 173 (3):145-150. [Details]
O'Connor, A,Leyden, J,McEntee, G,MacMathuna, P; (2004) 'Palliative stenting of recurrent malignancy at gastrojejunostomy anastomotic sites'. Irish Journal of Medical Science, 173 :219-220. [Details]
Goh, J; Godson, C; Brady, HR; MacMathuna, P; ; (2003) 'Lipoxins: Pro-resolution lipid mediators in intestinal inflammation'. Journal of Gastroenterology, 124 (4):1043-1054. [Details]
Goh, J; Otridge, B; Brady, H; Breatnach, E; Dervan, P; MacMathuna, P; ; (2001) 'Aggressive multiple myeloma presenting as mesenteric panniculitis'. American Journal of Gastroenterology, 96 (1):238-241. [Details]
Clarke, GA,Ryan, E,Crowe, JP,O'Keane, JC,MacMathuna, P; (2001) 'Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death'. Colorectal Disease, 16 :108-111. [Details]
Goh, J,Baird, AW,O'Keane, C,Watson, RWG,Cottell, D,Bernasconi, G,Petasis, NA,Godson, C,Brady, HR,MacMathuna, P; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Journal of Immunology, 167 :2772-2780. [Details]
Canny, GO; Drudy, D; Mac Mathuna, P; O'Farrelly, C; Baird, AW; ; (2001) 'Comparison of toxigenic and non toxigenic Clostridium difficile on T84 cell inflammatory phenotype'. Journal of Gastroenterology, 120 (5):326-326. [Details]
Clarke, G,Ryan, E,O'Keane, JC,Crowe, J,MacMathuna, P; (2000) 'The detection of cytokeratins in lymph nodes of Duke's B colorectal cancer subjects predicts a poor outcome'. Journal of Gastroenterology, 12 :549-552. [Details]
Goh, J; Baird, AW; Watson, WR; Godson, C; O'Keane, C; Brady, HR; MacMathuna, P; ; (2000) 'Lipoxins attenuate TNF-A-induced apoptosis in human colonic mucosa'. Journal of Gastroenterology, 118 (4):806-806. [Details]
MACMATHUNA, P,WHITE, P,CLARKE, E,MERRIMAN, R,LENNON, JR,CROWE, J; (1995) 'ENDOSCOPIC BALLOON SPHINCTEROPLASTY (PAPILLARY DILATION) FOR BILE-DUCT STONES - EFFICACY, SAFETY, AND FOLLOW-UP IN 100 PATIENTS'. Gastrointestinal Endoscopy, 42 :468-474. [Details]
MACMATHUNA, P,WHITE, P,CLARKE, E,LENNON, J,CROWE, J; (1994) 'ENDOSCOPIC SPHINCTEROPLASTY - A NOVEL AND SAFE ALTERNATIVE TO PAPILLOTOMY IN THE MANAGEMENT OF BILE-DUCT STONES'. Gut, 35 :127-129. [Details]
MACMATHUNA, P,LENNON, J,CROWE, J; (1993) 'ENDOSCOPIC BALLOON SPHINCTEROPLASTY FOR BENIGN PAPILLARY STENOSIS - AN ALTERNATIVE TO SURGICAL OR ENDOSCOPIC PAPILLOTOMY'. Irish Journal of Medical Science, 162 :355-357. [Details]
MACMATHUNA, P,VLAVIANOS, P,WESTABY, D,WILLIAMS, R; (1992) 'PATHOPHYSIOLOGY OF PORTAL-HYPERTENSION'. Journal of Digestive Diseases, 10 :3-15. [Details]
 

Conference Publications

Horgan G, Murray DW, Madden A, Bennett G, Ryan J, Anquetin G, Murphy PV, MacMathuna P and Doran P ; (2008) Novel Migrastatin Analogues Reduce Gastric Cancer Cell Migration Without Exhibiting Cytotoxic Effects American Gastroenterological Association : Digestive Disease Week , pp.742 [Details]
Horgan H, Murray D, Madden A, Bennett B, Anquetin G, Murphy P, Lennon J, MacMathuna P and Doran P; (2008) Gastric Cancer Cell Migration Is Reduced By Novel Migrastatin Analogues British Gastroenterology Meeting , pp.23 [Details]
Murray DW, MacMathuna P and Doran P ; (2007) Netl, a novel gastric adenocarcinoma-associated gene, drives tumor migration and invasion via cytoskeletal rearrangement events AGA DDW 07 , pp.628 [Details]
Lowlor G, Moss A, Tighe D, Murray DW, O'Keane C, Doran P and MacMathuna P ; (2006) Functional significance of enhanced ETV4 and MYEOV expression in colorectal neoplasia using sirna-mediated gene knockdown AGA DDW [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2006) NET1 - A Novel Activator of RhoA and Gastric Cancer Cell Invasion The Irish Association for Cancer Research Annual Meeting [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2006) NET1 - a novel activator of gastric tumor cell invasion and RhoA The American Association for Cancer Research 97th Annual Meeting [Details]
Canny, G, Drudy, D, MacMathuna, P, O'Farrelly, C, Baird, AW, ; (2006) LIFE SCIENCES Toxigenic C-difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical , pp.920-925 [Details]
Murray DW, Leyden J, McEntee G, O'Keane C, MacMathuna P and Doran P ; (2006) NET1 - A novel activator of RhoA and gastric cancer cell invasion AGA DDW [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2006) NET1 - A Novel Activator of RhoA and Gastric Cancer Cell Invasion Mater Misericordiae University Hospital - Young Investigators Research Symposium [Details]
Murray DW, Leyden J, Arumuguma M, Doyle E, McEntee G, O'Keane C, MacMathuna P, Doran P. ; (2006) NET1 - a novel activator of gastric tumour cell invasion and RhoA American Association for Cancer Research Annual Meeting [Details]
Lawlor, G., Murray, D, Moss, A., Leyden, J., Sadlier, D., O' Keane, C., Mulligan, AM., Arumuguma, M., Doyle, E., McEntee, G., MacMathuna, P. Doran, P.; (2006) Gastrointestinal Epithelial Cancers ' A Common Gene Expression Profile? The Irish Association for Cancer Research Annual Meeting [Details]
Lawlor, G., Tighe, T.G., Moss, A., Murray, D., Madden, S., Mulligan, A.M., O'Keane, C., Brady, H., Doran, P. MacMathuna, P.; (2006) Functional Significance of Enhanced Etv4 and Myeov Expression in Colorectal Neoplasia using siRNA-Mediated Gene Knockdown Mater Misericordiae University Hospital - Young Investigators Research Symposium [Details]
Lawlor, G., Moss, A., Tighe, D., Murray, D., Madden, S., Mulligan, AM., O'Keane, C., Brady, H., Doran, P. MacMathuna, P.; (2006) Functional Significance of Enhanced Etv4 and Myeov Expression in Colorectal Neoplasia using siRNA-Mediated Gene Knockdown The Irish Association for Cancer Research Annual Meeting [Details]
Lawlor, G., Moss, A., Tighe, D., Murray, D., Madden, S., Mulligan, A.M., O'Keane, C., Brady, H., Doran, P. Mac Mathuna, P.; (2006) Functional Significance of enhanced ETV4 and Myeov Expression in Colorectal Neoplasia using Si-Mediated Gene Knockdown Digestive Diseases Week [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2005) NET1 - A Novel Activator of RhoA and Gastric Tumour Cell Invasion The Irish Society of Gastroenterology Annual Meeting [Details]
Lawlor, G., Moss, A., Tighe, D., Murray, D., Madden, S., Mulligan, A.M., O'Keane, C., Brady, H., Doran, P. Mac Mathuna, P.; (2005) Functional Significance of Enhanced ETV4 and Myeov expression in Colorectal Neoplasia Irish Society of Gastroenterology [Details]
   

Editorial

Leyden, J,O'Shea, C,Hegarty, S,MacMathuna, P; (2005) An unusual finding in a patient with iron deficiency anaemia. Editorial [DOI] [Details]
MacMathuna, P; (1997) Endoscopic treatment of bile duct stones: Should we cut or dilate the sphincter?. Editorial [Details]
                                                                                   

Research

Research Interests

Research interests include bio-informatics and gene regulation in GI Cancer, High Risk Colorectal Cancer, CT Colonography and Interventional Endoscopy.

Continued to pursue clinical and basic laboratory investigations culminating in peer reviewed publications and presentations. The focus has been on:

UGI Carcinogenesis

Enhanced Colorectal CT Imaging

Developing a DAMC strategy for High Risk Colorectal Cancer Clinical and Laboratory Investigations