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Researchers at UCD

Amanda O'Neill

Senior Technical Officer

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166818
Email: amanda.oneill@ucd.ie

Biography

2003- Present Post-Doc/Lab Manager with Career track status, Surgical Research Laboratory, Dept. Surgery,Conway Institute, UCD
1998-Present Post-Doc Research Fellow, Surgical Research Laboratory, Dept Surgery,Conway Institute, UCD Mater Misericordiae Hospital, Dublin
1993-1997 Ph.D. St. James's Hospital and Trinity College Dublin

Professional

               

Education

Year 1997 Institution: Trinity College Dublin
Qualification: PhD Subject:
Year 1993 Institution: University College Dublin
Qualification: BSc Subject:
         

Publications

     

Peer Reviewed Journals

Eliwan HO, Watson RW;Aslam S;Regan I;Philbin B;O'Hare FM;O'Neill A;Preston R;Blanco A;Grant T;Nolan B;Smith O;Molloy EJ (2015) 'Neonatal brain injury and systemic inflammation: modulation by activated protein C ex vivo'. Clinical and Experimental Immunology, 179 (3):477-484. [DOI] [Details]
O'Hare FM, Watson RW;O'Neill A;Blanco A;Donoghue V;Molloy EJ (2015) 'Persistent systemic monocyte and neutrophil activation in neonatal encephalopathy'. Journal of Maternal-Fetal and Neonatal Medicine, :1-8. [DOI] [Details]
Onwuneme C, Blanco A;O'Neill A;Watson B;Molloy EJ (2015) 'Vitamin D enhances Reactive Oxygen Intermediates Production in Phagocytic Cells in Term and Preterm Infants'. Pediatric Research, . [DOI] [Details]
Prencipe M, O'Neill A;O'Hurley G;Nguyen LK;Fabre A;Bjartell A;Gallagher WM;Morrissey C;Kay EW;Watson RW (2015) 'Relationship between serum response factor and androgen receptor in prostate cancer'. Prostate, 75 (15):1704-1717. [DOI] Link to full text [Details]
O'Hare FM, Watson W;O'Neill A;Grant T;Onwuneme C;Donoghue V;Mooney E;Downey P;Murphy J;Twomey A;Molloy EJ (2015) 'Neutrophil and monocyte toll-like receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in preterm infants'. Pediatric Research, 78 (1):82-90. [DOI] [Details]
O'Hurley G, Prencipe M, Lundon D, O'Neill A, Boyce S, O'Grady A, Gallagher WM, Morrissey C, Kay EW, Watson RW (2014) 'The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases'. Prostate, 74 (3):306-313. [DOI] Link to full text [Details]
Prencipe M, Madden SF, O'Neill A, O'Hurley G, Culhane A, O'Connor D, Klocker H, Kay EW, Gallagher WM, Watson WR (2013) 'Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target?'. Prostate, 73 (7):743-753. [DOI] [Details]
Cahalane AM, Kelly RM, O'Neill A, Moran D, Butler MW, Keane MP, Lawler L, Dodd JD; (2012) 'Bronchopleural cutaneous fistula after pulmonary radiofrequency ablation: treatment with low-adherent paraffin gauze dressing'. Journal of Vascular and Interventional Radiology, 23 (2):283-285. [DOI] [Details]
O'Connell K, Prencipe M, O'Neill A, Corcoran C, Rani S, Henry M, Dowling P, Meleady P, O'Driscoll L, Watson W, O'Connor R (2012) 'The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines'. Proteomics, 12 (13):2115-2126. [DOI] [Details]
O'Neill A.J., Prencipe M., Dowling C., Fan Y., Mulrane L., Gallagher W.M., O'Connor D., O'Connor R., Devery A., Corcoran C., Rani S., O¿Driscoll L., Fitzpatrick J., R., Watson R.W.G. ; (2011) 'Characterisation and Manipulation of Docetaxel Resistant Prostate Cancer Cell Lines'. MOL CANCER, . [Details]
Gill, C.,Dowling, C.,O'Neill, A. J.,Watson, R. W.; (2009) 'Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation'. Mol Cancer, 8 :3939. Available Online [Details]
Byrne, JC,Downes, MR,O'Donoghue, N,O'Keane, C,O'Neill, A,Fan, Y,Fitzpatrick, JM,Dunn, MJ,Watson, RWG; (2009) '2D-DIGE as a Strategy To Identify Serum Markers for the Progression of Prostate Cancer'. Journal of Proteome Research, 8 :942-957. [DOI] [Details]
Gill, C,Dowling, C,O'Neill, AJ,Watson, RWG; (2009) 'Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation'. Journal of Cancer, 8 . [DOI] [Details]
Watson RW, Walsh S, Gill C, O'Neill A, Fitzpatrick JM, ; (2009) 'Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation'. International Journal of Cancer, 8 (NA):1871-1878. [DOI] [Details]
Dodd JD, Ryan ER, Martos R, O'Neill A, Mc Creery C, ; (2009) 'Coronary ostial involvement in acute aortic dissection: detection with 64-slice cardiac CT'. Clinical Imaging, 33 (6):471-473. [DOI] [Details]
McDermott E, O'Neill A, O'Sullivan MJ, ; (2008) 'Spontaneous common bile duct rupture in a pregnant female-A rare cause of peritonitis'. Obstetrics and Gynecology, . [DOI] [Details]
Molloy, E. J., O'Neill, A. J., Grantham-Sloan, J. J., Webb, D. W., Watson, R. W. G., ; (2008) 'Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis'. Clinical and Experimental Immunology, 151 (2):244-250. [Details]
Molloy, EJ,O'Neill, AJ,Grantham-Sloan, JJ,Webb, DW,Watson, RWG; (2008) 'Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis'. Journal of Immunology, 151 :244-250. [DOI] [Details]
Watson RW, Molloy EJ, O'Neill AJ, Grantham-Sloan JJ, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, ; (2007) 'Neonatal encephalopathy is associated with altered perinatal systemic neutrophil apoptosis'. American Journal of Perinatology, 9 (NA):525-530. [DOI] [Details]
Long, RM,Morrissey, C,Walsh, S,Hamilton, HJ,Farrell, N,O'Neill, A,Fitzpatrick, JM,Watson, WR; (2007) 'Alterations in the expression of inhibitors of apoptosis during differentiation of prostate epithelial cells'. BJU International, 100 :445-449. [DOI] [Details]
Bannon, JH,Fichtner, I,O'Neill, A,Pampillon, C,Sweeney, NJ,Strohfeldt, K,Watson, RW,Tacke, M,Mc Gee, MM; (2007) 'Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo'. British Journal of Cancer, 97 :1234-1241. [DOI] [Details]
Lebret, T; Watson, RWG; Molinie, V; Poulain, JE; O'Neill, A; Fitzpatrick, JM; Botto, H; ; (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. European Urology, 51 (1):161-167. [Details]
Healy, DG, Wood, AE, ONeill, A, McCarthy, JF, Fitzpatrick, JM, Watson, RW, ; (2007) 'Can preoperative modelling of individual neutrophil adhesion responses predict renal morbidity?'. European Journal of Cardio-thoracic Surgery, 31 :1088-1093. [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2007) 'Maternal and Neonatal Lipopolysaccharide and Fas responses are altered by sepsis'. Clinical & Experimental Immunology, . [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2007) 'Maternal and neonatal lipopolysaccharide responses are altered in encephalopathy'. American Journal of Perinatology, . [Details]
K. ONeill, A. OConnor, S. F. McGee, D. F. OShea, J. Murtagh, S. McDonnell, W. M. Gallagher, A. T. Byrne, K.M. Curran; (2007) 'Application of In Vivo Optical Imaging To Examine the Therapeutic Effect and Bioistribution Patterns of a New Class Of Photodynamic Therapy Agent'. The Irish Journal of Medical Science, 176 . [Details]
Healy D, Watson RWG, O Keane C, O Neill AL, Egan JJ, McCarthy JF, Hurley J, Fitzpatrick JM, Wood AE; (2006) 'Individual variation in early neutrophil infiltration of the allograft influences rejection in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 (5):760-766. [Details]
Watson, RWG; O'Neill, A; Brannigan, AE; Coffey, R; Marshall, JC; Brady, HR; Fitzpatrick, JM; ; (2006) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent (vol 453, pg 67, 1999)'. FEBS Letters, 580 (3):996-996. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Murphy, M; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2006) 'TGF-beta(1)-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. American Journal of Physiology - Renal Physiology, 290 (5):1202-1212. [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology, Supplements, 5 (14):797-797. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
Molloy EJ, O'Neill AJ, Doyle BT, Grantham J, Taylor Ct, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2006) 'Altered lipopolysaccharide-induced neutrophil responses following hypoxia and heatshock in both adults and neonates in vitro'. Biology of the Neonate, 90 (1):34-39. [Details]
Docherty, N.G., O'Sullivan, O.E., Healy, D.A., Murphy, M., O'Neill, A.J., Fitzpatrick, J.M. Watson, R.W.G.; (2005) 'TGF-beta1-induced EMT can occur independently of it proapoptotic effects and is aided by EGF receptor activation'. Am J Phy Reanl Phy, :f1202-f1212. [Details]
Healy, DG; Watson, RW; O'Neill, AJ; Egan, JJ; McCarthy, JF; Hurley, JP; Fitzpatrick, JM; Wood, AE; ; (2005) 'Cytoimmunological surveillance in human cardiac transplantation with the neutrophil'. British Journal of Surgery, 92 (10):1322-1322. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2005) 'Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function'. Pediatric Research, 57 (6):806-812. [Details]
Morrissey, C; O'Neill, A; Spengler, B; Christoffel, V; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells'. Prostate, 63 (2):131-142. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Willson, RWG; ; (2004) 'Is fever immunologically beneficial to adults or neonates? neonatal neutrophil responses to sepsis and heat shock'. Pediatric Research, 55 (4):399-399. [Details]
Bates, JJ; Watson, RWG; Glynn, CM; O'Neill, AJ; Fitzpatrick, JM; Buggy, DJ; ; (2004) 'Aspirin preserves neutrophil apoptosis after cardiopulmonary bypass'. Shock, 21 (6):495-499. [Details]
A.J. O'Neill, M.C. Greenan, B. Doyle, J.M. Fitzpatrick, R.W.G. Watson; (2004) 'Gene profiling of in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?'. Biochemical Society Transactions, 32 (Pt3) (NA):470-473. [Details]
Doyle, BT,O'Neill, AJ,Fitzpatrick, JM,Watson, RWG; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 :345-352. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; ; (2004) 'Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness'. Pediatric Research, 55 (4):398-399. [Details]
O'Neill, AJ; Doyle, BT; Molloy, E; Watson, C; Phelan, D; Greenan, MC; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Gene expression profile of inflammatory neutrophils: Alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis'. Shock, 21 (6):512-518. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2004) 'Labor promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. Pediatric Research, 56 (1):99-103. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; ; (2004) 'Labor induces a maternal inflammatory response syndrome'. American Journal of Obstetrics and Gynecology, 190 (2):448-455. [Details]
Hegarty NJ, Young LS, O'Neill AJ, Watson RW, Fitzpatrick JM; (2003) 'Endothelin in unilateral uretheral obstruction: vascular and cellular effects'. Urology, 169 (2):740-744. [Details]
Molloy, EJ,O'Neill, AJ,Grantham, JJ,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RWG; (2003) 'Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone'. Blood, 102 :2653-2659. [Details]
Lebret, T,Watson, RWG,Molinie, V,O'Neill, A,Gabriel, C,Fitzpatrick, JM,Botto, H; (2003) 'Heat shock proteins HSP27, HSP60, HSP70, and HSP90'. Journal of Cancer, 98 :970-977. [DOI] [Details]
Murphy, BM,O'Neill, AJ,Adrain, C,Watson, RWG,Martin, SJ; (2003) 'The apoptosome pathway to caspase activation in primary human Neutrophils exhibits dramatically reduced requirements for cytochrome c'. Journal of Experimental Medicine, 197 :625-632. [DOI] [Details]
Hegarty, NJ,Watson, RWG,Young, LS,O'Neill, AJ,Brady, HR,Fitzpatrick, JM; (2002) 'Cytoprotective effects of nitrates in a cellular model of hydronephrosis'. Kidney International, 62 :70-77. [Details]
McEleny, KR; Watson, RWG; Coffey, RNT; O'Neill, AJ; Fitzpatrick, JM; ; (2002) 'Inhibitors of apoptosis proteins in prostate cancer cell lines'. Prostate, 51 (2):133-140. [Details]
Doyle, BT,O'Neill, AJ,Newsholme, P,Fitzpatrick, JM,Watson, RWG; (2002) 'The loss of IAP expression during HL-60 cell differentiation is caspase-independent'. Journal of Leukocyte Biology, 71 (NA):247-254. [Details]
Coffey, RNT; Watson, RWG; O'Neill, AJ; Mc Eleny, K; Fitzpatrick, JM; ; (2002) 'Androgen-mediated resistance to apoptosis'. Prostate, 53 (4):300-309. [Details]
Doyle, B., ONeill, A., Newsholme, P., Fitzpatrick, J.M., and Watson, R.W.G.; (2002) 'HL-60 cell differentiation and apoptosis is associated with decreased inhibitors of apoptosis proteins expression and increased caspase activity'. Journal of Leukocite Biology, 71 :247-254. [Details]
Muckian, C., Fitzgerald, A., O'Neill, A., O'Byrne, A., Fitzgerald, D. J., Shields, D. C.; (2002) 'Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease'. Blood, 100 (4):1220-3. [Details]
O'Neill, AJ,Boran, SA,O'Keane, C,Coffey, RNT,Hegarty, NJ,Hegarty, P,Gaffney, EF,Fitzpatrick, JM,Watson, RWG; (2001) 'Caspase 3 expression in benign prostatic hyperplasia and prostate carcinoma'. Prostate, 47 :183-188. [Details]
Hurley, H; Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2001) 'Heat shock protein expression inhibits etoposide induced apoptosis in HL60 cells'. FASEB Journal, 15 (4):315-315. [Details]
Doyle, BT; O'Neill, AJ; Newsholme, P; Fitzpatrick, JM; Watson, RWG; ; (2001) 'HL-60 cell differentiation and resulting apoptosis is associated with decreased expression of the inhibitors of apoptosis protein'. FASEB Journal, 15 (4):313-313. [Details]
Molloy, EJ; O'Neill, AJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2001) 'Maternal and neonatal apoptosis at delivery: A mechanism for bacterial susceptibility?'. FASEB Journal, 15 (4):369-369. [Details]
ONeill A.J. , B.T. Doyle, A. Murphy, J.M. Fitzpatrick, R.W.G. Watson.; (2001) 'Gene profile of Inflammatory Neutrophils'. Irish Journal of Medical Science, 170 (1):78. [Details]
Hegarty, NJ,Young, LS,Kirwan, CN,O'Neill, AJ,Bouchier-Hayes, DM,Sweeney, P,William, R,Watson, G,Fitzpatrick, JM; (2001) 'Nitric oxide in unilateral ureteral obstruction: Effect on regional renal blood flow'. Kidney International, 59 :1059-1065. [Details]
O'Neill, AJ; Doyle, BT; Fitzpatrick, JM; Watson, RWG; ; (2001) 'Inhiitors of apoptosis proteins expressed at a basal level in normal or inflammatory neutrophils'. FASEB Journal, 15 (4):335-335. [Details]
Smith, JD; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Cellular glutathione extrusion is an integral part of neutrophil apoptosis'. FASEB Journal, 14 (4):194-194. [Details]
O'Neill, S; O'Neill, AJ; Conroy, E; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. Journal of Leukocyte Biology, 68 (1):15-20. [Details]
Coffey, R.N.T., Watson, R.W.G., Hegarty, N.J., ONeill, A., Gibbons, N., Brady, H.R., and Fitzpatrick, J.M.; (2000) 'Thiol mediated apoptosis in prostate cancer cells'. Journal of Cancer, 88 :2092-2104. [Details]
O'Neill, AJ; O'Neill, S; Hegarty, NJ; Coffey, RNT; Gibbons, N; Brady, H; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent'. Shock, 14 (6):605-609. [Details]
Brannigan, AE,O'Connell, PR,Hurley, H,O'Neill, A,Brady, HR,Fitzpatrick, JM,Watson, RWG; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 :361-366. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Neutrophil apoptosis is associated with altered caspase processing'. FASEB Journal, 14 (4):194-194. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (1999) 'Differential role of the mitochondria in neutrophil apoptosis'. FASEB Journal, 13 (5):661-661. [Details]
Watson, RWG,O'Neill, A,Brannigen, AE,Coffey, R,Marshall, JC,Brady, HR,Fitzpatrick, JM; (1999) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent'. FEBS Letters, 453 :67-71. [Details]
O'Neill, S; Conroy, E; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (1999) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. FASEB Journal, 13 (5):661-661. [Details]
O'Neill, AJ; Murtagh, JC; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (1999) 'Delayed neutrophil apoptosis is associated with altered caspase 3 processing'. Journal of Leukocyte Biology, -1 (NA):25-25. [Details]
Watson, RWG; Coffey, R; O'Neill, A; Fitzpatrick, JM; ; (1999) 'Caspase protease manipulation: a novel approach to apoptotic induction in prostate cancer'. Prostate Cancer and Prostatic Diseases, 2 (NA):34-34. [Details]

Other Journals

Molloy, E.J., O'Neill, A.J., Doyle, B.T., Grantham, J.J., Taylor, C.T., Sheridan-Pereira, M., Fitzpatrick, J.M. Watson, R.W.G.; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, toll-like receptor-4 and CD11b expression compared with adults' Biology of the Neonate . [Details]

Conference Publications

Edgar Galvan‐Lopez, John Mark Swafford, Michael O'Neill, and Anthony Brabazon; (2010) Evolving a Ms. PacMan Controller using Grammatical Evolution . In: Lecture Notes in Computer Science Vol. 6024, Springer eds. 2nd European event on Bio-inspired Algorithms in Games (EvoGames 2010) Istanbul, Turkey, , 07-APR-10 - 09-APR-10 , pp.161-170 [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis European Association of Urology , pp.797-797 [Details]
F. T. O'Neill, A. J. Carr, S. M. Daniels, M. R. Gleeson , J. V. Kelly, J. R. Lawrence, J. T. Sheridan; (2005) Photo-embossed optical elements and microfluidic lens fabrication Proc. SPIE [Details]
F. T. O'Neill, A. J. Carr, S. M. Daniels, M. R. Gleeson, J. V. Kelly, J. R. Lawrence, J. T. Sheridan; (2004) Refractive optical elements produced in photopolymer layers Photonics Europe, SPIE conference Strasbourg, , 26-APR-04 - 30-APR-04 [Details]
J. Culloty, B. O Neill and O. Feely (2000) Nonlinear dynamics of first-order DPLL with FM input Proc. Irish Signals and Systems Conf Dublin, , pp.97-102 [Details]
                                                                                         

Research

Research Interests

My research specifically involves investigating the role of phytoestrogens in the prevention and treatment of Prostate Cancer. Phytoestrogens are non-steroidal plant-derived compounds with estrogenic activity, implicated in protecting against prostate cancer progression. A number of plants contain large amounts of Phytoestrogens. Dietary phytoestrogens have been implicated in prostate cancer prevention, however, the phytoestrogens are now under investigation as a possible treatment for prostate cancer as they display anti-androgenic potential, in vitro growth inhibition, and apoptosis in prostate cancer cells and in vivo reduction in tumour incidence. Epigallocatechin gallate (EGCG), a component of green tea and potent antioxidant, has been shown to induce apoptosis in prostate cancer cells in vitro. The aims of this study are to determine if hypoxia alters the effects of EGCG on metastatic prostate cell number and apoptosis as well as mitochondrial activity and oxidative cellular changes. We have demonstrated that even though hypoxia increases mitochondrial anti-oxidant levels and membrane stability, EGCG still induces significant apoptosis, indicating its possible use in established tumours.

FUNDING AGENCIES:
Mater College for Postgraduate Education and Research Grant 2003.
Health Research Board (co-applicant)
Irish Cancer Society (co-applicant)
Enterprise Ireland-Basic Research Grant