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Researchers at UCD

Christine Costello

College Lecturer

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166724
Email: christine.costello@ucd.ie

Professional

         

Conference Contributions

Howell, K., Costello, C., McLoughlin, P.; Hypoxia and Lung Disease Conference. [Poster Presentation], European Respiratory Society, Taormina, Sicily .
Nichol, A., Howell, K., Costello, C. & McLoughlin, P.; Hypoxia Conference. [Poster Presentation], Keystone Symposium, Breckenridge, Colorado, USA .
               

Publications

     

Peer Reviewed Journals

Costello, C. M.,Cahill, E.,Martin, F.,Gaine, S.,McLoughlin, P.; 'Role of gremlin in the lung: development and disease'. Am J Respir Cell Mol Biol, 42 (55):517-23517. Available Online [Details]
McCullagh BN, Costello CM;Li L;O'Connell C;Codd M;Lawrie A;Morton A;Kiely DG;Condliffe R;Elliot C;McLoughlin P;Gaine S (2013) 'Elevated plasma CXCL12¿¿ is associated with a poorer prognosis in pulmonary arterial hypertension'. PLoS ONE, 10 (4). [DOI] [Details]
Adamali H, Armstrong ME, McLaughlin AM, Cooke G, McKone E, Costello CM, Gallagher CG, Leng L, Baugh JA, Fingerle-Rowson G, Bucala RJ, McLoughlin P, Donnelly SC (2012) 'Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis'. American Journal of Respiratory and Critical Care Medic, 186 (2):162-169. [DOI] [Details]
Cahill E, Costello CM, Rowan SC, Harkin S, Howell K, Leonard MO, Southwood M, Cummins EP, Fitzpatrick SF, Taylor CT, Morrell NW, Martin F, McLoughlin P; (2012) 'Gremlin plays a key role in the pathogenesis of pulmonary hypertension'. Circulation, 125 (7):920-930. [DOI] Link to full text [Details]
Sands M, Howell K, Costello CM, McLoughlin P; (2011) 'Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung'. Respiratory research, 12 (1). [DOI] [Details]
Costello CM, McCullagh B, Howell K, Sands M, Belperio JA, Keane MP, Gaine S, McLoughlin P.; (2011) 'A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease'. European Respiratory Journal, . [Details]
McLoughlin P, Costello CM, Cahill E, Martin F, Gaine S, ; (2010) 'Role of Gremlin in the Lung: Development and Disease'. American Journal of Respiratory Cell and Molecular Biology, 42 (5):517-523. [DOI] [Details]
Howell, K.,Costello, C. M.,Sands, M.,Dooley, I.,McLoughlin, P.; (2009) 'L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension'. Am J Physiol Lung Cell Mol Physiol, 296 (66). Available Online [Details]
Howell, K,Costello, CM,Sands, M,Dooley, I,McLoughlin, P; (2009) 'L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension'. American journal of physiology. Lung cellular and molecular physiology, 296 (NA):1042-1050. [DOI] [Details]
Mathivanan, S.,Ahmed, M.,Ahn, N. G.,Alexandre, H.,Amanchy, R.,Andrews, P. C.,Bader, J. S.,Balgley, B. M.,Bantscheff, M.,Bennett, K. L.,Bjorling, E.,Blagoev, B.,Bose, R.,Brahmachari, S. K.,Burlingame, A. S.,Bustelo, X. R.,Cagney, G.,Cantin, G. T.,Cardasis, H. L.,Celis, J. E.,Chaerkady, R.,Chu, F.,Cole, P. A.,Costello, C. E.,Cotter, R. J.,Crockett, D.,DeLany, J. P.,De Marzo, A. M.,DeSouza, L. V.,Deutsch, E. W.,Dransfield, E.,Drewes, G.,Droit, A.,Dunn, M. J.,Elenitoba-Johnson, K.,Ewing, R. M.,Van Eyk, J.,Faca, V.,Falkner, J.,Fang, X.,Fenselau, C.,Figeys, D.,Gagne, P.,Gelfi, C.,Gevaert, K.,Gimble, J. M.,Gnad, F.,Goel, R.,Gromov, P.,Hanash, S. M.,Hancock, W. S.,Harsha, H. C.,Hart, G.,Hays, F.,He, F.,Hebbar, P.,Helsens, K.,Hermeking, H.,Hide, W.,Hjerno, K.,Hochstrasser, D. F.,Hofmann, O.; (2008) 'Human Proteinpedia enables sharing of human protein data'. Nat Biotechnol, 26 (2):164-7. Available Online [Details]
McLoughlin P, Costello CM, Howell K, Cahill E, McBryan J, Konigshoff M, Eickelberg O, Gaine S, Martin F, ; (2008) 'Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension'. Cell, 295 (2):1-84. [DOI] [Details]
McLoughlin P, Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, ; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. Critical Care Medicine, 178 (9):977-983. [DOI] [Details]
Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, McLoughlin P; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, . [Details]
Wada, Y,Azadi, P,Costello, CE,Dell, A,Dwek, RA,Geyer, H,Geyer, R,Kakehi, K,Karlsson, NG,Kato, K,Kawasaki, N,Khoo, KH,Kim, S,Kondo, A,Lattova, E,Mechref, Y,Miyoshi, E,Nakamura, K,Narimatsu, H,Novotny, MV,Packer, NH,Perreault, H,Peter-Katalinic, J,Pohlentz, G,Reinhold, VN,Rudd, PM,Suzuki, A,Taniguchi, N; (2007) 'Comparison of the methods for profiling glycoprotein glycans - HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study'. Glycobiology, 17 (4):411-422. Available Online [DOI] [Details]
Barr, A.,Nolan, M.,Grant, W.,Costello, C.,Petrou, M. A.; (2006) 'Rhinoorbital and pulmonary zygomycosis post pulmonary aspergilloma in a patient with chronic lymphocytic leukaemia'. Acta Biomed, 77 Suppl 4 :13-8. [Details]
Burton, R.,Kelion, Z.,Costello, C.; (2006) 'Severe folate deficiency in pregnancy with normal red cell folate level'. Clin Lab Haematol, 28 (1):66-8. [Details]
Hyvelin, JM,Howell, K,Nichol, A,Costello, CM,Preston, RJ,McLoughlin, P; (2005) 'Inhibition of rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation, 97 :185-191. [DOI] [Details]
Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P.; (2005) 'Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation Research, 97 (2):185-191. [Details]
Lu, T,Costello, CM,Croucher, PJP,Hasler, R,Deuschl, GN,Schreiber, S; (2005) 'Can Zipf's law be adapted to normalize microarrays?'. BMC Bioinformatics, 6 . [DOI] [Details]
Henry, MT; McMahon, K; Costello, C; FitzGerald, MX; O'Connor, CM; ; (2002) 'Secretory leukocyte proteinase inhibitor and elafin are resistant to degradation by MMP-8'. Experimental Lung Research, 28 (2):85-97. [Details]
Russell, KJ; McRedmond, J; Mukherji, N; Costello, C; Keatings, V; Linnane, S; Henry, M; Fitzgerald, MX; O'Connor, CM; ; (1998) 'Neutrophil adhesion molecule surface expression and responsiveness in cystic fibrosis'. American Journal of Respiratory and Critical Care Medicine, 157 (3):756-761. [Details]
Linnane, SJ,Keatings, VM,Costello, CM,Moynihan, JB,O'Connor, CM,Fitzgerald, MX,McLoughlin, P; (1998) 'Total sputum nitrate plus nitrite is raised during acute pulmonary infection in cystic fibrosis'. American Journal of Respiratory and Critical Care Medicine, 158 :207-212. [Details]
 

Conference Publications

Dr. Brian McCullagh, Christine Costello, christine.costello@ucd.ie, Sean Gaine, sgaine@mater.ie, Paul McLoughlin; (2010) CXCL12 as a potential disease marker for pulmonary hypertension European Respiratory Society Annual Congress [Details]
Cahill E, Costello CM, Howell K, Harkin S, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2010) Novel Autocrine Function of the BMP Antagonist Gremlin: a Key Role in Hypoxic Pulmonary Hypertension American Thoracic Society International Conference 2010 [Details]
Cahill E, Costello CM, Howell K, Southwood M, Leonard, M.O., Morrell NW, McLoughlin P; (2010) Lung-Selective Hypoxia-Induced Secretion of the BMP Antagonist Gremlin in Pulmonary Hypertension Keystone Symposium [Details]
Coyle-Rowan S, Cahill E, Harkin S, Costello CM, Howell K, Martin F, McLoughlin P; (2010) Hypoxic upregulation of the BMP antagonist gremlin1 contributes to the development of pulmonary hypertension Physiological Society Main Meeting (2010), Birmingham; Proc Physiol Soc 20, PC06 Available Online [Details]
Costello, CM, Howell K, Doherty S, Martin, F, Belperio J, Keane MP, Gaine, S, McLoughlin, P; (2010) CXCL12 signalling in hypoxic pulmonary hypertension American Thoracic Society International Conference [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells European Respiratory Society Lung Biology Meeting [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells Physiological Society Annual Meeting [Details]
Costello, CM, Howell K, Brennan D, Doherty S, Martin, F, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress European Respiratory Society Lung Biology Meeting [Details]
Costello CM, Howell K, Doherty S, Martin F, Belperio J, Keane M, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress Physiological Society Annual General Meeting [Details]
Nichol, A., Howell, K., Costello, C. McLoughlin, P.; (2006) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Keystone Conferrnce [Details]
                                                                                         

Research

Research Interests

Research Projects

Sponsor : University College Dublin (UCD)
Title : A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease - publication costs in the European Respiratory Journal.
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : University College Dublin (UCD)
Title : Examination of the role of microRNA gene targeting in the pathogenesis of human pulmonary vascular disease
Start Date / End Date : 01-OCT-12 / 30-SEP-15
Sponsor : Health Research Board (HRB)
Title : Lung selective dysregulation of the CXCR7/CXCL12 biological axis: a novel pathomechanism in human pulmonary vascular disease
Start Date / End Date : 01-OCT-13 / 30-SEP-16
Sponsor : University College Dublin (UCD)
Title : miRNAs in vascular lung disease - conference participation
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : Science Foundation Ireland (SFI)
Title : Identification and characterisation of lung selective microRNAs that contribute to the unique response of the pulmonary vasculature to hypoxia
Start Date / End Date : 01-SEP-10 / 31-AUG-14
Sponsor : Health Research Board (HRB)
Title : Characterisation of the role of CXCL12/CXCR4 biological axis in hypoxia mediated angiogenesis in the adult lung
Start Date / End Date : 01-OCT-07 / 31-JAN-11