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Ciara Murphy

Lecturer In Anatomy

School Of Medicine
Health Sciences Centre
Belfield
Dublin 4

Tel: 01 716 6624
Email: ciara.murphy.1@ucd.ie

Biography

Dr. Ciara Murphy is a graduate in Biological Sciences from the National University of Ireland, Maynooth (2006). On completion of her degree, she carried out research for her PhD in the area of bone tissue engineering under the supervision of Prof. Fergal O'Brien in the Royal College of Surgeons in Ireland (RCSI) (2010). Subsequently, she joined Prof. David Little's Orthopaedic & Biotechnology Research (ORB) Group in the Children's Hospital at Westmead, Sydney, Australia, where she focused her post-doctoral research on orthopaedic regenerative medicine, specifically:

Developing a number of biologic delivery systems that utilised numerous tissue engineering technologies, including collagen-based scaffolds

Developing novel drug based therapies for improved bone healing

This work lead to a successful project which applied Teriparatide (PTH(1-34)) treatment as a mechanism for ameliorating BP burden within BP loaded fractures - a study for which she was awarded the New Investigator Recognition Award at the 2014 International Orthopaedic Research Society (ORS). 

She returned to Ireland in 2015 where she joined UCD as a Lecturer in Human Anatomy in the School for Medicine and Medical Sciences.

Dr. Murphy's research interests are in developing advanced biomaterials as innovative platforms for targeted therapeutic delivery, disease model systems and 3-D studies of cell-matrix interactions.

Professional

Honours and Awards

Year: 2014.
Title: New Investigator Recognition Award (NIRA)
Year: 2013.
Title: Travel Grant Award
Year: 2012.
Title: Travel Grant Award
Year: 2010.
Title: Best Oral Presentation

Associations

Association: Anatomical Society, Function/Role: Member
Association: Orthopaedic Research Society, Function/Role: Member
           

Education

Year 2010 Institution: Royal College of Surgeons in Ireland
Qualification: PhD Subject: Bone Tissue Engineering
Year 2006 Institution: NUI Maynooth, IRL
Qualification: BSc Subject:
         

Publications

     

Peer Reviewed Journals

CM Murphy, GP Duffy, A Schindeler, FJ O'brien (2015) 'Effect of collagen‐glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types'. Journal of Biomedical Materials Research - Part A, . [Details]
T.L. Cheng, C.M. Murphy, R. Ravarian, F. Dehghani, D.G. Little, A. Schindeler (2015) 'Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering¿'. Tissue engineering, . [Details]
N.Y.C. Yu, C.M. Murphy, A. Fathi, L.C. Cantrill, K. Mikulec, L. Peacock, F. Dehghani, A. Schindeler and D.G. Little (2015) 'Local delivery of anti-resorptive cathepsin K inhibitor to modulate rhBMP-2 induced ectopic bone formation'. Journal of Biomedical Materials Research Part A, . [DOI] [Details]
R. Rayarian, C.M. Murphy, A. Schindeler, A. Rawal, J.M. Hook, F. Dehghani (2015) 'Bioactive poly(methyl methacrylate) for bone fixation'. Rsc Advances, . [DOI] [Details]
N.Y.C. Yu, M. Gdalevitch, C.M. Murphy, K. Mikulec, L. Peacock , J. Fitzpatrick, L.C. Cantrill, A.J. Ruys, J.J. Cooper-White, D.G. Little, A. Schindeler (2014) 'Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhBMP-2 and anti- catabolic agents'. European Cells and Materials, . [Details]
C.M. Murphy, A. Schindeler., L.C. Cantrill, K. Mikulec, L. Peacock and D.G. Little (2014) 'PTH(1-34) Treatment Increases Bisphosphonate Turnover in Fracture Repair'. Journal of Bone and Mineral Research, . [DOI] [Details]
K. Shen, C.M. Murphy, B. Chan, M. Kollind, T. Cheng, K. Mikulec, L. Peacock, M. Xue, S.Y. Park, D.G. Little, C. Jackson, A. Schindeler (2014) 'Activated Protein C (APC) can increase bone anabolism via a Protease-Activated Receptor (PAR)1/2 dependent mechanism'. Journal of Orthopaedic Research, . [DOI] [Details]
T.L. Cheng, C.M. Murphy, L.C. Cantrill, K. Mikulec, C. Carpenter, A. Schindeler, D.G. Little (2014) 'Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs'. International Orthopaedics, . [DOI] [Details]
C.M Murphy, A. Schindeler, J.P. Gleeson, N.Y.C. Yu, L.C. Cantrill, K. Mikulec, L. Peacock, F.J. O'Brien, D.G. Little (2014) 'A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates'. Acta Biomaterialia, . [DOI] [Details]
T.L. Cheng, P. Valtchev, C.M. Murphy, L.C. Cantrill, F. Dehghani, D.G. Little, A. Schindeler (2013) 'A sugar-based phase-transitioning delivery system for bone tissue engineering'. European Cells and Materials, . [Details]
R. Ravarian, X. Zhong, M. Barbeck, S. Ghanaati, C.J. Kirkpatrick, C.M Murphy, A. Schindeler, Chrzanowski W, Dehghani F (2013) 'Nanoscale chemical interaction enhances the physical properties of bioglass composites'. ACS Nano, . [DOI] [Details]
C.M. Murphy, F.J. O'Brien, D.G. Little, A. Schindeler (2013) 'Cell-Scaffold Interactions in the Bone Tissue Engineering Triad'. European Cells and Materials, . [Details]
C.M. Murphy, A. Matsiko, M.G. Haugh, J.P. Gleeson, F.J. O'Brien (2012) 'Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen-glycosaminoglycan scaffolds¿'. Journal of the Mechanical Behavior of Biomedical Materials, . [DOI] [Details]
M.G. Haugh, C.M. Murphy, R.C McKiernan, C. Altenbuchner, F.J. O'Brien (2011) 'Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds'. Tissue Engineering Part A, . [DOI] [Details]
C.M. Murphy, M.G. Haugh, F.J. O'Brien (2010) 'The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering'. Biomaterials, . [DOI] [Details]
F.G. Lyons, A.A. Al‐Munajjed, S.M. Kieran, M.E. Toner, C.M. Murphy, G.P. Duffy and F.J. O¿Brien (2010) 'The healing of bony defects by cell‐free collagen‐based scaffolds compared to stem cell‐seeded tissue engineered constructs'. Biomaterials, . [DOI] [Details]
M.G. Haugh, C.M. Murphy, F.J. O'Brien (2009) 'Novel freeze‐drying methods to produce a range of collagen‐GAG scaffolds with tailored mean pore sizes'. Tissue Engineering Part C: Methods, . [DOI] [Details]
                                                                                             

Research

 

Research Projects

Sponsor : University College Dublin (UCD)
Title : Local delivery of PTH(1-34) from an injectable collagen-hydroxyapatite scaffold for non-invasive treatment of bisphosphonate associated atypical femoral fractures
Start Date / End Date : 01-APR-16 / 30-SEP-17
 

Current Postgraduate Students

Caitriona Tiernan, Master of Science (MSc)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201500   ANAT10110     Human Anatomy: Clinical Human Anatomy I