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Cinzia Raso

Research Fellow

School Of Medicine

Tel:
Email: cinzia.raso@ucd.ie

Biography

 After completion of my M.Sc. studies in Molecular Biology (5 years) in Italy, I successfully achieved two Ph.D. degrees: the first in Animal Pharmacological  and Toxicological Sciences at the University Federico II, Naples, and the second in Biomedical and Computer Engineering at Magna Graecia University, Catanzaro. During this last Ph.D., I decided to improve my skills in mass spectrometry and chromatographic techniques spending a period as visiting scientist in Yates`s Lab, Scripps Research Institute, San Diego, California.

From 2012 to the end of 2015 I joined UCD, as Post-Doctoral Research Fellow level II in Systems Biology Ireland, under the advisorship of Prof. Walter Kolch, being involved in PRIMES (Protein Interaction Machines in EGFR Signaling) (FP7-HEALTH-2011-two-stage), focusing on the identification of protein-protein interaction network related to EGFR network by mass spectrometry (Q-Exactive, Thermo).
 

I joined the Biomedical Proteomic Team, held by Prof. Stephen Pennington, in the early January 2016, as Research Fellow on an Enterprise Ireland grant. Here my work is focused on the discovery and validation of blood protein signature, by MRM/MS, able to discriminate if prostate cancer is organ confined or has spread beyond the prostate. 

Professional

Honours and Awards

Year: 2008.
Title: Young Scientist Award
             

Education

Year 2011 Institution:
Qualification: PhD Subject: Biomedical and Computer Engineering, University Magna Graecia, Catanzaro
Year 2008 Institution:
Qualification: PhD Subject: Pharmacology and Toxicology in Animal Sciences, University Federico II, Naples
         

Publications

     

Peer Reviewed Journals

Bryan K, Jarboui MA, Raso C, Bernal-Llinares M, McCann B, Rauch J, Boldt K, Lynn DJ. (2016) 'HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data'. PLoS ONE, . [DOI] [Details]
Fasterius E, Raso C, Kennedy S, Rauch N, Lundin P, Kolch W, Uhlén M, Al-Khalili Szigyarto C. (2017) 'A novel RNA sequencing data analysis method for cell line authentication'. PLoS ONE, 12 (2). [DOI] [Details]
Malara NM, Givigliano F;Trunzo V;Macrina L;Raso C;Amodio N;Aprigliano S;Minniti AM;Russo V;Roveda L;Coluccio ML;Fini M;Voci P;Prati U;Di Fabrizio E;Mollace V (2015) 'In vitro expansion of tumour cells derived from blood and tumour tissue is useful to redefine personalized treatment in non-small cell lung cancer patients'. Journal of Biological Regulators and Homeostatic Agents, 28 (4):717-731. [Details]
Roperto S, Russo V, Borzacchiello G, Urraro C, Lucà R, Esposito I, Riccardi MG, Raso C, Gaspari M, Ceccarelli DM, Galasso R, Roperto F. (2014) 'Bovine papillomavirus type 2 (BPV-2) E5 oncoprotein binds to the subunit D of the V₁-ATPase proton pump in naturally occurring urothelial tumors of the urinary bladder of cattle'. PLoS ONE, 9 (2). [Details]
Malara N, Coluccio ML, Limongi T, Asande M, Trunzo V, Cojoc G, Raso C, Candeloro P, Perozziello G, Raimondo R, De Vitis S, Roveda L, Renne M, Prati U, Mollace V, Di Fabrizio E (2014) 'Folic acid functionalized surface highlights 5-methylcytosine-genomic content within circulating tumor cells'. Small, 10 (21):4324. [Details]
Turriziani, B. and Garcia-Munoz, A. and Pilkington, R. and Raso, C. and Kolch, W. and von Kriegsheim, A. (2014) 'On-beads digestion in conjunction with data-dependent mass spectrometry: A shortcut to quantitative and dynamic interaction proteomics'. Biology, 3 (2):320-332. Available Online [DOI] [Details]
Raso C., Cosentino C., Malara N., Gaspari M., Han X., Park SK., McClatchy DB., Renne M., Vadalà N., Cuda G., Mollace V., Yates JR. 3rd., Amato F. (2012) 'Characterization of breast cancer interstitial fluids by TMT labeling, LTQ-Orbitrap Velos mass spectrometry and pathway analysis'. Journal of Proteome Research, . [Details]
Paduano F., Ortuso F., Campiglia P., Raso C., Iaccino E., Gaspari M., Gaudio E., Mangone G., Carotenuto A., Bilotta A., Narciso D., Palmieri C., agosti V., Artese A., Gomez-Monterrey I., Sala M., Cuda G., Iuliano R., Perrotti N., Scala G., Viglietto G., Alcaro S., Croce CM., Novellino E., Fusco A., Trapasso F. (2012) 'Isolation and Functional Characterization of Peptide Agonists of PTPRJ, a Tyrosine Phosphatase Receptor Endowed with Tumor Suppressor Activity'. ACS Chemical Biology, . [Details]
Bonadies F., Berardi G., Nicoletti R., Romolo F.S., De Giovanni F., Mirablli R., Santoro A., Raso C., Tagarelli A., Roperto F., Russo V., Roperto S (2011) 'A new, very sensitive method of assessment of ptaquiloside, the major bracken carcinogen in the milk of farm animals'. Food Chemistry, . [Details]
Roperto S., Borzacchiello G., Brun R., Costanzo F., Faniello M.C., Raso C., Rosati A., Russo V., Saracino D, Turco M.C., Urraro C, Roperto F. (2010) 'Ferritin heavy chain (FHC) is upregulated in papillomavirus-associated urothelial tumor of the urinary bladder in cattle'. Journal of Comparative Pathology, . [Details]
Roperto S., De Tullio R., Raso C., Stifanese R., Russo V., Gaspari M.,Borzacchiello G., Averna M., Paciello O., Cuda G., Roperto F (2010) 'Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle'. PLoS ONE, . [Details]
S. Roperto, N.A. Colabufo, C. Inglese, C. Urraro, R. Brun, E. Mezza, C., Staibano S., Raso C., P. Maiolino, V. Russo, E. Palma, F. Roperto (2010) 'Sigma-2 receptors expression in bovine papillomavirus-associated urinary bladder tumours'. Journal of Comparative Pathology, . [Details]
Iuliano R., Raso C., Quintiero A., Le Pera I.,Pichiorri F., Palumbo T., Palmieri D., Pattarozzi A., Florio T., Viglietto G., Trapasso F., Croce C.M. and Fusco A (2009) '. The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization'. Biochemistry, . [Details]
F. Trapasso, F. Pichiorri, M. Gaspari, T. Palumbo, R. I. Aqeilan, E. Gaudio, H. Okumura, R. Iuliano, G. Di Leva, M. Fabbri, D. E. Birk, C. Raso, K. Green-Church, L. G. Spagnoli, S. Venuta, K.Huebner, and C. M. Croce (2008) 'Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells'. Journal of Biological Chemistry, . [Details]
Roperto S, Brun B, Paolini F, Urraro C, Russo V, Borzacchiello G, Pagnini U, Raso C., Rizzo C, Roperto F, and Venuti A (2008) 'Detection of Bovine Papillomavirus Type 2 in the Peripheral Blood of Cattle with Urinary Bladder Tumours: Possible Biological Role'. Journal of General Virology, . [Details]
F. Trapasso, A. Drusco, S. Costinean, H. Alder, R. Aqeilan, R. Iuliano, E. Gaudio, C. Raso, N. Zanesi, C. M. Croce, and A. Fusco (2006) 'Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis'. DNA and cell biology, . [Details]
                                                                                                                     

Research

Research Interests


I joined the Biomedical Proteomic Team, held by Prof. Stephen Pennington, in the early January 2016, as Research Fellow on an Enterprise Ireland grant.  My work is focused on the discovery and validation of blood protein signature, by MRM/MS, able to discriminate if prostate cancer is still organ confined or has spread beyond the prostate.

Previously I was PD2 in Systems Biology Ireland, involved in PRIMES (Protein Interaction Machines in EGFR Signalling) (FP7-HEALTH-2011-two-stage).PRIMES focused on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses.